Search

To analyze the impacts of groins, sandbars, and channels on the three-dimensional features of rip currents, we conducted experimental investigations on the vertical distribution of rip currents under intersecting waves along barred beaches with channels. This study employed ADV flow velocity measurements at two distinct locations: within channel and on a sandbar. The results indicate that in nodal sections within channel and on a sandbar, the rip head region manifests surface flow characteristics, characterized by high velocities near water surface. In a rip neck location, the vertical distribution of rip currents on a sandbar exhibits greater variability, whereas within channel, the distribution is more homogeneous. The vertical distribution of rip currents in nodal sections within channel aligns with the logarithmic distribution law. The vertical distributions of the alongshore velocity of rip currents display a consistent pattern of higher at the top and lower at the bottom. However, this pattern varies slightly depending on the wave period. The presence of groins influences the fluctuation characteristics of the alongshore velocity of rip currents by regulating the nearshore circulation system. This results in the alongshore velocity of rip currents in channel pointing towards the groin. In contrast, the alongshore velocity of rip currents on sandbar, situated farther away from groin, exerts a weaker effect on the alongshore velocity of a rip current. [ABSTRACT FROM AUTHOR]

Diabetic retinopathy is one of the major diabetic complications and remains the most common cause of adult blindness among patients with diabetes mellitus. Polygonatum sibiricum polysaccharides (PSP) are a group important component of Polygonatum sibiricum (PS) with anti-diabetic activity. However, the effect and underlying mechanism of PSP on diabetic retinopathy remains unclear. We used high glucose (HG)-stimulated ARPE-19 cells to establish in vitro diabetic retinopathy model. Methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay was performed to evaluate cell viability of ARPE-19 cells. The changes in the ROS production, malondialdehyde (MDA) content, and activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were detected to indicate oxidative stress. The secretion levels of tumor necrosis factor-alpha (TNF-α) and interleukin-8 (IL-8) were detected by ELISA. The protein levels of TNF-α, IL-8, bcl-2, bax, nuclear Nrf2, and anti-hemeoxygenase-1 (HO-1) were detected by western blot analysis. Our results showed that HG treatment caused a significant reduction in cell viability of ARPE-19 cells. PSP treatment improved the reduced cell viability of ARPE-19 cells. PSP also attenuated HG-induced oxidative stress with decreased ROS production and MDA content, as well as increased the activities of SOD and GPx. In addition, HG significantly increased bax expression and caspase-3 activity, and decreased bcl-2 expression. However, these changes were mitigated by PSP treatment. Furthermore, PSP markedly induced the activation of Nrf2/HO-1 pathway in HG-induced ARPE-19 cells. Knockdown of Nrf2 reversed the protective effects of PSP on HG-induced ARPE-19 cells. Taken together, these findings indicated that PSP protects ARPE-19 cells from HG-induced oxidative stress, inflammation, and cell apoptosis through regulation of Nrf2/HO-1 signaling pathway. [ABSTRACT FROM AUTHOR]

Auditory phonological processing skills are critical for successful reading development in English not only in native (L1) speakers but also in second language (L2) learners. However, the neural deficits of auditory phonological processing remain unknown in English-as-the-second-language (ESL) learners with reading difficulties. Here we investigated neural responses during spoken word rhyme judgments in typical and impaired ESL readers in China. The impaired readers showed comparable activation in the left superior temporal gyrus (LSTG), but reduced activation in the left inferior frontal gyrus (LIFG) and left fusiform and reduced connectivity between the LSTG and left fusiform when compared to typical readers. These findings suggest that impaired ESL readers have relative intact representations but impaired manipulation of phonology and reduced or absent automatic access to orthographic representations. This is consistent with previous findings in native English speakers and suggests a common neural mechanism underlying English impairment across the L1 and L2 learners. [ABSTRACT FROM PUBLISHER]