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18 results on '"Song, Lairong"'

7. PD‐L1 regulates tumor proliferation and T‐cell function in NF2‐associated meningiomas.

Author

Wang, Ying, Zhang, Chao, Yan, Minjun, Ma, Xin, Song, Lairong, Wang, Bo, Li, Peng, and Liu, Pinan

Subjects
PROGRAMMED death-ligand 1, NEUROFIBROMATOSIS 2, T cells, TUMOR-infiltrating immune cells, IMMUNOSUPPRESSION, NEUROFIBROMATOSIS 1
Abstract

Introduction: Programmed death‐ligand 1 (PD‐L1) expression is an immune evasion mechanism that has been demonstrated in many tumors and is commonly associated with a poor prognosis. Over the years, anti‐PD‐L1 agents have gained attention as novel anticancer therapeutics that induce durable tumor regression in numerous malignancies. They may be a new treatment choice for neurofibromatosis type 2 (NF2) patients. Aims: The aims of this study were to detect the expression of PD‐L1 in NF2‐associated meningiomas, explore the effect of PD‐L1 downregulation on tumor cell characteristics and T‐cell functions, and investigate the possible pathways that regulate PD‐L1 expression to further dissect the possible mechanism of immune suppression in NF2 tumors and to provide new treatment options for NF2 patients. Results: PD‐L1 is heterogeneously expressed in NF2‐associated meningiomas. After PD‐L1 knockdown in NF2‐associated meningioma cells, tumor cell proliferation was significantly inhibited, and the apoptosis rate was elevated. When T cells were cocultured with siPD‐L1‐transfected NF2‐associated meningioma cells, the expression of CD69 on both CD4+ and CD8+ T cells was partly reversed, and the capacity of CD8+ T cells to kill siPD‐L1‐transfected tumor cells was partly restored. Results also showed that the PI3K–AKT–mTOR pathway regulates PD‐L1 expression, and the mTOR inhibitor rapamycin rapidly and persistently suppresses PD‐L1 expression. In vivo experimental results suggested that anti‐PD‐L1 antibody may have a synergetic effect with the mTOR inhibitor in reducing tumor cell proliferation and that reduced PD‐L1 expression could contribute to antitumor efficacy. Conclusions: Targeting PD‐L1 could be helpful for restoring the function of tumor‐infiltrating lymphocytes and inducing apoptosis to inhibit tumor proliferation in NF2‐associated meningiomas. Dissecting the mechanisms of the PD‐L1‐driven tumorigenesis of NF2‐associated meningioma will help to improve our understanding of the mechanisms underlying tumor progression and could facilitate further refinement of current therapies to improve the treatment of NF2 patients. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Landscape of the oncogenic role of fatty acid synthase in human tumors

Author

Huo, Xulei, Song, Lairong, Li, Da, Wang, Ke, Wang, Yali, Chen, Feng, Zhang, Liwei, Wang, Liang, Zhang, Junting, and Wu, Zhen

Subjects
fatty acid synthase, tumor, Aging, phosphorylation, Carcinogenesis, Kaplan-Meier Estimate, Cell Biology, DNA Methylation, tumor-infiltrating immune cell, Gene Expression Regulation, Neoplastic, Neoplasms, expression, Humans, prognosis, methylation, Fatty Acid Synthases, Transcriptome, Research Paper, Genes, Neoplasm
Abstract

Background: Identifying a unique and common regulatory pathway that drives tumorigenesis in cancers is crucial to foster the development of effective treatments. However, a systematic analysis of fatty acid synthase across pan-cancers has not been carried out. Methods: We investigated the oncogenic roles of fatty acid synthase in 33 cancers based on the cancer genome atlas and gene expression omnibus. Results: Fatty acid synthase is profoundly expressed in most cancers and is an important factor in predicting the outcome of cancer patients. Further, the level of S207 phosphorylation was found to be improved in several neoplasms (e.g., colon cancer). Fatty acid synthase expression is related to tumor-infiltrating immune cells in tumors (e.g., CD8+ T-cell infiltration level in cervical squamous cell carcinoma). Moreover, hormone receptor binding- and fatty acid metabolic process-associated pathways are involved in the functional mechanisms of fatty acid synthase. Conclusions: This study provides a complete understanding of the oncogenic role of fatty acid synthase in human tumors.

Published
2021

13. TGFB3 downregulation causing chordomagenesis and its tumor suppression role maintained by Smad7

Author

Wang, Liang, primary, Guan, Xiaonan, additional, Hu, Qingtao, additional, Wu, Zhen, additional, Chen, Wei, additional, Song, Lairong, additional, Wang, Ke, additional, Tian, Kaibing, additional, Cao, Chunwei, additional, Zhang, Dake, additional, Ma, Junpeng, additional, Tong, Xiangjun, additional, Zhang, Bo, additional, Zhang, Junting, additional, and Zeng, Changqing, additional

Published
2021
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14. High Copy-Number Variation Burdens in Cranial Meningiomas From Patients With Diverse Clinical Phenotypes Characterized by Hot Genomic Structure Changes

Author

Ma, Junpeng, primary, Hong, Yaqiang, additional, Chen, Wei, additional, Li, Da, additional, Tian, Kaibing, additional, Wang, Ke, additional, Yang, Yang, additional, Zhang, Yuan, additional, Chen, Yujia, additional, Song, Lairong, additional, Chen, Liangpeng, additional, Zhang, Liwei, additional, Du, Jiang, additional, Zhang, Junting, additional, Wu, Zhen, additional, Zhang, Dake, additional, and Wang, Liang, additional

Published
2020
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