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247 results on '"Song, Kwang Hoon"'

7. The HPLC–PDA Method for Simultaneous Determination of Regalosides from Bulbs of Lilium lancifolium Thunb. and Their Antioxidant Effects.

Author

Seo, Chang-Seob, Kim, No Soo, and Song, Kwang-Hoon

Subjects
HIGH performance liquid chromatography, GRADIENT elution (Chromatography), MATERIALS management, HERBAL medicine, FORMIC acid
Abstract

Lilium lancifolium Thunb. is a herbal medicine that is widely used to treat inflammation and lung diseases. In this study, a simultaneous quantitative method was developed for the quality control of BLL using high-performance liquid chromatography coupled with a photodiode array detector (HPLC–PDA), and their antioxidant effects were evaluated. Eight regalosides (i.e., regaloside A, B, C, E, F, H, I, and K) were selected as marker substances and separated on a Gemini C18 reversed-phase analytical column by gradient elution with distilled water–acetonitrile mobile phase containing 0.1% (v/v) formic acid. The method was validated with respect to linearity, sensitivities (limit of detection (LOD) and limit of quantitation (LOQ)), accuracy, and precision. The antioxidant effects of the extract and each component were evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay and 2-2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assay. The coefficients of determination values used as indicators of linearity for all components were ≥0.9999. LOD and LOQ concentrations were 0.10–0.66 μg/mL and 0.29–2.01 μg/mL, respectively. The recovery was 95.39–103.925% (relative standard deviation; RSD ≤ 2.55%), and precision RSD was <2.78%. The HPLC–PDA method was applied to real samples, and all components were detected at 1.12–29.76 mg/freeze-dried g. The evaluation of antioxidant effects showed that regalosides C, E, and K exhibited significant antioxidant effects. Our knowledge will be appropriately utilized in raw material management and conducting clinical and non-clinical studies on L. lancifolium or herbal medicine prescriptions containing L. lancifolium. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Engineered full-length fibronectin-hyaluronic acid hydrogels for stem cell engineering

Author

Trujillo, Sara, Vega, Sebastián L., Song, Kwang Hoon, San Félix, Ana, Dalby, Matthew J., Burdick, Jason A., and Salmeron-Sanchez, Manuel

Subjects
technology, industry, and agriculture, macromolecular substances, complex mixtures
Abstract

Mechanical cues induce a variety of downstream effects on cells, including the regulation of stem cell behavior. Cell fate is typically characterized on biomaterial substrates where mechanical and chemical properties can be precisely tuned; however, most of these substrates do not recapitulate the biological complexity of the extracellular matrix (ECM). Here, hydrogels are engineered for mechanobiological studies using two major components of the ECM: hyaluronic acid (HA) and fibronectin (FN). Rather than typical surface chemisorption of FN to substrates, the system contains full‐length FN covalently crosslinked to HA throughout the hydrogel. The control over the mechanical properties of the hydrogel independent of the concentration of FN and the ability to culture viable cells either on top or encapsulated within the hydrogels are shown. Interestingly, human mesenchymal stem cells (MSCs) experience an increase in nuclear translocation of the yes‐associated protein (YAP) to the nucleus when cultured on (2D) substrates with increasing amounts of FN while maintaining constant hydrogel stiffness. However, this FN dependence on nuclear YAP translocation is not observed for MSCs encapsulated in (3D) hydrogels. This work develops complex hydrogels that recapitulate features of the ECM for the control of stem cells in both 2D and 3D environments.

Published
2020

33. Nuclear softening expedites interstitial cell migration in fibrous networks and dense connective tissues

Author

Heo, Su-Jin, primary, Song, Kwang Hoon, additional, Thakur, Shreyasi, additional, Miller, Liane M., additional, Cao, Xuan, additional, Peredo, Ana P., additional, Seiber, Breanna N., additional, Qu, Feini, additional, Driscoll, Tristan P., additional, Shenoy, Vivek B., additional, Lakadamyali, Melike, additional, Burdick, Jason A., additional, and Mauck, Robert L., additional

Published
2020
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45. Withdrawal: Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2.

Author

Song, Kwang-Hoon, primary, Park, Yun-Yong, additional, Kee, Hae Jin, additional, Hong, Cheol Yi, additional, Lee, Yong-Soo, additional, Ahn, Seung-Won, additional, Kim, Hye-Jin, additional, Lee, Keesook, additional, Kook, Hyun, additional, Lee, In-Kyu, additional, and Choi, Heung-Sik, additional

Published
2019
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