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102 results on '"Song, Joong-Hyun"'

8. Korean Black Goat Extract Exerts Estrogen-like Osteoprotective Effects by Stimulating Osteoblast Differentiation in MC3T3-E1 Cells and Suppressing Osteoclastogenesis in RAW 264.7 Cells.

Author

Akter, Reshmi, Son, Jin Sung, Ahn, Jong Chan, Morshed, Md Niaj, Lee, Gyong Jai, Kim, Min Jun, An, Jeong Taek, Kong, Byoung Man, Song, Joong-Hyun, Yang, Deok Chun, Awais, Muhammad, and Yang, Dong Uk

Subjects
CELL differentiation, RUNX proteins, OSTEOCLASTOGENESIS, TUMOR necrosis factors, BONE resorption, WNT signal transduction, BONE regeneration
Abstract

Postmenopausal osteoporosis, characterized by an imbalance between osteoclast-mediated bone resorption and osteoblast-driven bone formation, presents substantial health implications. In this study, we investigated the role of black goat extract (BGE), derived from a domesticated native Korean goat, estrogen-like activity, and osteoprotective effects in vitro. BGE's mineral and fatty acid compositions were analyzed via the ICP-AES method and gas chromatography–mass spectrometry, respectively. In vitro experiments were conducted using MCF-7 breast cancer cells, MC3T3-E1 osteoblasts, and RAW264.7 osteoclasts. BGE exhibits a favorable amount of mineral and fatty acid content. It displayed antimenopausal activity by stimulating MCF-7 cell proliferation and augmenting estrogen-related gene expression (ERα, ERβ, and pS2). Moreover, BGE positively impacted osteogenesis and mineralization in MC3T3-E1 cells through Wnt/β-catenin pathway modulation, leading to heightened expression of Runt-related transcription factor 2, osteoprotegerin, and collagen type 1. Significantly, BGE effectively suppressed osteoclastogenesis by curtailing osteoclast formation and activity in RAW264.7 cells, concurrently downregulating pivotal signaling molecules, including receptor activator of nuclear factor κ B and tumor necrosis factor receptor-associated factor 6. This study offers a shred of preliminary evidence for the prospective use of BGE as an effective postmenopausal osteoporosis treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Sialocele and Its Association with Hypercortisolism and Long-Term Glucocorticoid Treatment in Dogs: Retrospective Case–Control Study.

Author

Bae, Jeong-Yeol, Kim, Jung-Il, Kim, Jin-Young, Joung, Guk-Il, Lee, Hong-Ju, Lee, Jae-Beom, and Song, Joong-Hyun

Subjects
DOGS, CYSTS (Pathology), CUSHING'S syndrome, GLUCOCORTICOIDS, CASE-control method, LOGISTIC regression analysis
Abstract

Simple Summary: Sialocele-related concurrent diseases or factors in dogs are not well documented, and occasionally, dogs with sialocele have been found to have concurrent hypercortisolism (HC) or a history of long-term glucocorticoid (GC) treatment. In this retrospective case–control study, we investigated the association between HC, long-term GC treatment, and the diagnosis of sialocele in dogs. The occurrence of sialocele was higher in dogs with HC and those receiving long-term GC treatment, that is, treatment lasting for more than 5 months. This suggests that endogenous and exogenous GCs may influence sialocele formation. Therefore, we recommend regular monitoring for sialocele occurrence in dogs with HC or those receiving long-term GC treatment. Dogs with sialocele often have concurrent hypercortisolism or are receiving long-term glucocorticoid treatment. However, their association has not been investigated. This retrospective matched case–control study investigated the association between hypercortisolism, long-term glucocorticoid treatment, and sialocele in dogs. We retrospectively reviewed the records from 1 January 2018 to 31 December 2022. Records of 19 dogs diagnosed with sialocele were investigated for hypercortisolism and long-term glucocorticoid treatment. Two age- and breed-matched controls for each sialocele dog (38 dogs) were investigated for the same concurrent diseases. Logistic regression analysis was used. The odds of sialocele in dogs with hypercortisolism were 15.56 times those of dogs without hypercortisolism (p = 0.02; 95% CI: 1.54–156.79). The odds of sialocele in dogs with long-term glucocorticoid treatment (median, 8 months; range, 5–13) were 7.78 times those of dogs without long-term glucocorticoid treatment (p = 0.03; 95% CI: 1.23–49.40). No associations were found between age, sex, body weight, and the presence of sialocele. The results indicate that sialocele was significantly associated with hypercortisolism and long-term glucocorticoid treatment in dogs. Therefore, dogs with hypercortisolism or receiving long-term glucocorticoid therapy should be screened for possible sialocele. Additionally, dogs with sialocele should be identified for concurrent hypercortisolism and prolonged glucocorticoid exposure. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Thiamine deficiency in a dog associated with exclusive consumption of boiled sweet potato (Ipomoea batatas): Serial changes in clinical findings, magnetic resonance imaging findings and blood lactate and thiamine concentrations.

Author

Song, Joong‐Hyun and Jung, Dong‐In

Subjects
*VITAMIN B1, *BLOOD lactate, *SWEET potatoes, *MAGNETIC resonance imaging, *HIGH performance liquid chromatography, *ESSENTIAL nutrients, *VITAMIN B1 deficiency, *DOG diseases
Abstract

Thiamine (vitamin B1) is an essential nutrient that significantly influences ATP production in the body. It needs to be supplemented consistently through an exogenous source to prevent deficiency; however, it is easily affected by a variety of mitigating factors. Additionally, thiamine requirements can be influenced by an individual's dietary composition. The nervous system is particularly vulnerable to thiamine deficiency due to its high metabolic demand. Thiamine deficiency is typically diagnosed based on clinical signs, dietary history and response to thiamine administration. A 5‐year‐old neutered male Maltese Terrier dog presented with an acute onset of seizures and generalized ataxia. The dog was exclusively fed boiled sweet potato (Ipomoea batatas) as a primary diet source for 4 weeks. MR findings and hyperlactatemic conditions were consistent with thiamine deficiency, and the diagnosis was confirmed by measuring thiamine concentrations in blood using high‐performance liquid chromatography (HPLC). Appropriate thiamine supplementation and diet changes resulted in a rapid improvement in neurological signs. Repeated MR imaging 2 weeks after starting the treatment completely resolved the previously identified abnormalities, and repeated measurements of blood lactate and thiamine levels revealed complete recovery of the thiamine‐deficient status. [ABSTRACT FROM AUTHOR]

Published
2021
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