489 results on '"Sonestedt E."'
Search Results
2. Are we using more sugar substitutes? Wastewater analysis reveals differences and rising trends in artificial sweetener usage in Swedish urban catchments
- Author
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Haalck, Inga, Székely, A., Ramne, S., Sonestedt, E., von Brömssen, C., Eriksson, E., Lai, F.Y., Haalck, Inga, Székely, A., Ramne, S., Sonestedt, E., von Brömssen, C., Eriksson, E., and Lai, F.Y.
- Abstract
The market for artificial sweeteners as substitutes for conventional sugar (sucrose) is growing, despite potential health risks associated with their intake. Estimating population usage of artificial sweeteners is therefore crucial, and wastewater analysis can serve as a complement to existing methods. This study evaluated spatial and temporal usage of artificial sweeteners in five Swedish communities based on wastewater analysis. We further compared their levels measured in wastewater with the restrictions during the COVID-19 pandemic in Sweden and assessed health risks to the Swedish population. Influent wastewater samples (n = 194) collected in March 2019-February 2022 from communities in central and southern Sweden were analyzed for acesulfame, saccharin, and sucralose using liquid-chromatography coupled with tandem mass spectrometry. Spatial differences in loads for individual artificial sweetener were observed, with sucralose being higher in Kalmar (southern Sweden), and acesulfame and saccharin in Enköping and Östhammar (central Sweden). Based on sucrose equivalent doses, all communities showed a consistent prevalence pattern of sucralose > acesulfame > saccharin. Four communities with relatively short monitoring periods showed no apparent temporal changes in usage, but the four-year monitoring in Uppsala revealed a significant (p < 0.05) annual increase of ∼19 % for sucralose, ∼9 % for acesulfame and ∼8 % for saccharin. This trend showed no instant or delayed effects from COVID-19 restrictions, reflecting positively on the studied population which retained similar exposure to the artificial sweeteners despite potential pandemic stresses. Among the three artificial sweeteners, only acesulfame’s levels were at the lower end of the health-related threshold for consumption of artificially sweetened beverages; yet, all were far below the accepta
- Published
- 2024
3. Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults
- Author
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Cordova, R., Knaze, V., Viallon, V., Rust, P., Schalkwijk, C. G., Weiderpass, E., Wagner, K-H., Mayen-Chacon, A-L., Aglago, E. K., Dahm, C. C., Overvad, K., Tjønneland, A., Halkjær, J., Mancini, F. R., Boutron-Ruault, M-C., Fagherazzi, G., Katzke, V., Kühn, T., Schulze, M. B., Boeing, H., Trichopoulou, A., Karakatsani, A., Thriskos, P., Masala, G., Krogh, V., Panico, S., Tumino, R., Ricceri, F., Spijkerman, A., Boer, J., Skeie, G., Rylander, C., Borch, K. B., Quirós, J. R., Agudo, A., Redondo-Sánchez, D., Amiano, P., Gómez-Gómez, J-H., Barricarte, A., Ramne, S., Sonestedt, E., Johansson, I., Esberg, A., Tong, T., Aune, D., Tsilidis, K. K., Gunter, M. J., Jenab, M., and Freisling, Heinz
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- 2020
- Full Text
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4. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants
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Zhou, B, Lu, Y, Hajifathalian, K, Bentham, J, Di Cesare, M, Danaei, G, Bixby, H, Cowan, MJ, Ali, MK, Taddei, C, Lo, WC, Reis-Santos, B, Stevens, GA, Riley, LM, Miranda, JJ, Bjerregaard, P, Rivera, JA, Fouad, HM, Ma, G, Mbanya, JC, McGarvey, ST, Mohan, V, Onat, A, Pilav, A, Ramachandran, A, Romdhane, HB, Paciorek, CJ, Bennett, JE, Ezzati, M, Abdeen, ZA, Abdul Kadir, K, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Aguilar-Salinas, CA, Agyemang, C, Ahmadvand, A, Al-Othman, AR, Alkerwi, A, Amouyel, P, Amuzu, A, Andersen, LB, Anderssen, SA, Anjana, RM, Aounallah-Skhiri, H, Aris, T, Arlappa, N, Arveiler, D, Assah, FK, Avdicová, M, Azizi, F, Balakrishna, N, Bandosz, P, Barbagallo, CM, Barceló, A, Batieha, AM, Baur, LA, Benet, M, Bernabe-Ortiz, A, Bharadwaj, S, Bhargava, SK, Bi, Y, Bjertness, E, Bjertness, MB, Björkelund, C, Blokstra, A, Bo, S, Boehm, BO, Boissonnet, CP, Bovet, P, Brajkovich, I, Breckenkamp, J, Brenner, H, Brewster, LM, Brian, GR, Bruno, G, Bugge, A, Cabrera de León, A, Can, G, Cândido, AP, Capuano, V, Carlsson, AC, Carvalho, MJ, Casanueva, FF, Casas, JP, Caserta, CA, Castetbon, K, Chamukuttan, S, Chaturvedi, N, Chen, CJ, Chen, F, Chen, S, Cheng, CY, Chetrit, A, Chiou, ST, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Concin, H, Cooper, C, Cooper, R, Costanzo, S, Cottel, D, Cowell, C, Crujeiras, AB, D'Arrigo, G, Dallongeville, J, Dankner, R, Dauchet, L, de Gaetano, G, De Henauw, S, Deepa, M, Dehghan, A, Deschamps, V, Dhana, K, Di Castelnuovo, AF, Djalalinia, S, Doua, K, Drygas, W, Du, Y, Dzerve, V, Egbagbe, EE, Eggertsen, R, El Ati, J, Elosua, R, Erasmus, RT, Erem, C, Ergor, G, Eriksen, L, Escobedo-de la Peña, J, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrari, M, Ferreccio, C, Feskens, EJ, Finn, JD, Föger, B, Foo, LH, Forslund, AS, Francis, DK, Franco Mdo, C, Franco, OH, Frontera, G, Furusawa, T, Gaciong, Z, Garnett, SP, Gaspoz, JM, Gasull, M, Gates, L, Geleijnse, JM, Ghasemian, A, Ghimire, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Giwercman, A, Gross, MG, González Rivas, JP, Gorbea, MB, Gottrand, F, Grafnetter, D, Grodzicki, T, Grøntved, A, Gruden, G, Gu, D, Guan, OP, Guerrero, R, Guessous, I, Guimaraes, AL, Gutierrez, L, Hambleton, IR, Hardy, R, Hari Kumar, R, Hata, J, He, J, Heidemann, C, Herrala, S, Hihtaniemi, IT, Ho, SY, Ho, SC, Hofman, A, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Htike, MM, Hu, Y, Hussieni, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikeda, N, Ikram, MA, Irazola, VE, Islam, M, Iwasaki, M, Jacobs, JM, Jafar, T, Jamil, KM, Jasienska, G, Jiang, CQ, Jonas, JB, Joshi, P, Kafatos, A, Kalter-Leibovici, O, Kasaeian, A, Katz, J, Kaur, P, Kavousi, M, Keinänen-Kiukaanniemi, S, Kelishadi, R, Kengne, AP, Kersting, M, Khader, YS, Khalili, D, Khang, YH, Kiechl, S, Kim, J, Kolsteren, P, Korrovits, P, Kratzer, W, Kromhout, D, Kujala, UM, Kula, K, Kyobutungi, C, Laatikainen, T, Lachat, C, Laid, Y, Lam, TH, Landrove, O, Lanska, V, Lappas, G, Laxmaiah, A, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Muñoz, LM, Li, Y, Lim, WY, Lima-Costa, MF, Lin, HH, Lin, X, Lissner, L, Lorbeer, R, Lozano, JE, Luksiene, D, Lundqvist, A, Lytsy, P, Machado-Coelho, GL, Machi, S, Maggi, S, Magliano, DJ, Makdisse, M, Mallikharjuna Rao, K, Manios, Y, Manzato, E, Margozzini, P, Marques-Vidal, P, Martorell, R, Masoodi, SR, Mathiesen, EB, Matsha, TE, McFarlane, SR, McLachlan, S, McNulty, BA, Mediene-Benchekor, S, Meirhaeghe, A, Menezes, AM, Merat, S, Meshram, II, Mi, J, Miquel, JF, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohd Yusoff, MF, Møller, NC, Molnár, D, Mondo, CK, Morejon, A, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Motta, J, Mu, TT, Muiesan, ML, Müller-Nurasyid, M, Mursu, J, Nagel, G, Námešná, J, Nang, EE, NangThetia, VB, Navarrete-Muñoz, EM, Ndiaye, NC, Nenko, I, Nervi, F, Nguyen, ND, Nguyen, QN, Nieto-Martínez, RE, Ning, G, Ninomiya, T, Noale, M, Noto, D, Nsour, MA, Ochoa-Avilés, AM, Oh, K, Ordunez, P, Osmond, C, Otero, JA, Owusu-Dabo, E, Pahomova, E, Palmieri, L, Panda-Jonas, S, Panza, F, Parsaeian, M, Peixoto, SV, Pelletier, C, Peltonen, M, Peters, A, Peykari, N, Pham, ST, Pitakaka, F, Piwonska, A, Piwonski, J, Plans-Rubió, P, Porta, M, Portegies, ML, Poustchi, H, Pradeepa, R, Price, JF, Punab, M, Qasrawi, RF, Qorbani, M, Radisauskas, R, Rahman, M, Raitakari, O, Rao, SR, Ramke, J, Ramos, R, Rampal, S, Rathmann, W, Redon, J, Reganit, PF, Rigo, F, Robinson, SM, Robitaille, C, Rodríguez-Artalejo, F, Rodriguez-Perez Mdel, C, Rodríguez-Villamizar, LA, Rojas-Martinez, R, Ronkainen, K, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Russo Horimoto, RV, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, Santos, D, dos Santos, RN, Santos, R, Saramies, JL, Sardinha, LB, Sarrafzadegan, N, Saum, KU, Scazufca, M, Schargrodsky, H, Scheidt-Nave, C, Sein, AA, Sharma, SK, Shaw, JE, Shibuya, K, Shin, Y, Shiri, R, Siantar, R, Sibai, AM, Simon, M, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Smeeth, L, Snijder, MB, So, HK, Sobngwi, E, Söderberg, S, Solfrizzi, V, Sonestedt, E, Soumare, A, Staessen, JA, Stathopoulou, MG, Steene-Johannessen, J, Stehle, P, Stein, AD, Stessman, J, Stöckl, D, Stokwiszewski, J, Stronks, K, Strufaldi, MW, Sun, CA, Sundström, J, Sung, YT, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tamosiunas, A, Tang, L, Tarawneh, M, Tarqui-Mamani, CB, Taylor, A, Theobald, H, Thijs, L, Thuesen, BH, Tolonen, HK, Tolstrup, JS, Topbas, M, Torrent, M, Traissac, P, Trinh, OT, Tulloch-Reid, MK, Tuomainen, TP, Turley, ML, Tzourio, C, Ueda, P, Ukoli, FA, Ulmer, H, Uusitalo, HM, Valdivia, G, Valvi, D, van Rossem, L, van Valkengoed, IG, Vanderschueren, D, Vanuzzo, D, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, WM, Verstraeten, R, Viet, L, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Vrijheid, M, Wade, AN, Wagner, A, Walton, J, Wan Mohamud, WN, Wang, F, Wang, MD, Wang, Q, Wang, YX, Wannamethee, SG, Weerasekera, D, Whincup, PH, Widhalm, K, Wiecek, A, Wijga, AH, Wilks, RJ, Willeit, J, Wilsgaard, T, Wojtyniak, B, Wong, TY, Woo, J, Woodward, M, Wu, FC, Wu, SL, Xu, H, Yan, W, Yang, X, Ye, X, Yoshihara, A, Younger-Coleman, NO, Zambon, S, Zargar, AH, Zdrojewski, T, Zhao, W, Zheng, Y, and Zuñiga Cisneros, J
- Published
- 2016
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5. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition
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IRAS OH Epidemiology Chemical Agents, Yammine, S G, Huybrechts, I, Biessy, C, Dossus, L, Panico, S, Sánchez, M J, Benetou, V, Turzanski-Fortner, R, Katzke, V, Idahl, A, Skeie, G, Olsen, K Standahl, Tjønneland, A, Halkjaer, J, Colorado-Yohar, S, Heath, A K, Sonestedt, E, Sartor, H, Schulze, M B, Palli, D, Crous-Bou, M, Dorronsoro, A, Overvad, K, Gurrea, A Barricarte, Severi, G, Vermeulen, R C H, Sandanger, T M, Travis, R C, Key, T, Amiano, P, Van Guelpen, B, Johansson, M, Sund, M, Tumino, R, Wareham, N, Sacerdote, C, Krogh, V, Brennan, P, Riboli, E, Weiderpass, E, Gunter, M J, Chajès, V, IRAS OH Epidemiology Chemical Agents, Yammine, S G, Huybrechts, I, Biessy, C, Dossus, L, Panico, S, Sánchez, M J, Benetou, V, Turzanski-Fortner, R, Katzke, V, Idahl, A, Skeie, G, Olsen, K Standahl, Tjønneland, A, Halkjaer, J, Colorado-Yohar, S, Heath, A K, Sonestedt, E, Sartor, H, Schulze, M B, Palli, D, Crous-Bou, M, Dorronsoro, A, Overvad, K, Gurrea, A Barricarte, Severi, G, Vermeulen, R C H, Sandanger, T M, Travis, R C, Key, T, Amiano, P, Van Guelpen, B, Johansson, M, Sund, M, Tumino, R, Wareham, N, Sacerdote, C, Krogh, V, Brennan, P, Riboli, E, Weiderpass, E, Gunter, M J, and Chajès, V
- Published
- 2023
6. Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: a pooled analysis of 96 population-based studies with 331 288 participants
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Danaei, G, Fahimi, S, Lu, Y, Zhou, B, Hajifathalian, K, Di Cesare, M, Lo, WC, Reis-Santos, B, Cowan, MJ, Shaw, JE, Bentham, J, Lin, JK, Bixby, H, Magliano, D, Bovet, P, Miranda, JJ, Khang, YH, Stevens, GA, Riley, LM, Ali, MK, Ezzati, M, Abdeen, ZA, Kadir, KA, Abu-Rmeileh, M, Acosta-Cazares, B, Aekplakorn, W, Aguilar-Salinas, CA, Ahmadvand, A, Al Nsour, M, Alkerwi, A, Amouyel, P, Andersen, LB, Anderssen, SA, Andrade, DS, Anjana, RM, Aounallah-Skhiri, H, Aris, T, Arlappa, N, Arveiler, D, Assah, FK, Avdicová, M, Balakrishna, N, Bandosz, P, Barbagallo, CM, Barceló, A, Batieha, AM, Baur, LA, Ben Romdhane, H, Bernabe-Ortiz, A, Bhargava, SK, Bi, Y, Bjerregaard, P, Björkelund, C, Blake, M, Blokstra, A, Bo, S, Boehm, BO, Boissonnet, CP, Brajkovich, I, Breckenkamp, J, Brewster, LM, Brian, GR, Bruno, G, Bugge, A, Cabrera de León, A, Can, G, Cândido, AP, Capuano, V, Carvalho, MJ, Casanueva, FF, Caserta, CA, Castetbon, K, Chamukuttan, S, Chaturvedi, N, Chen, CJ, Chen, F, Chen, S, Cheng, CY, Chetrit, A, Chiou, ST, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Concin, H, Cooper, C, Cooper, R, Costanzo, S, Cottel, D, Cowell, C, Crujeiras, AB, D'Arrigo, G, Dallongeville, J, Dankner, R, Dauchet, L, de Gaetano, G, De Henauw, S, Deepa, M, Dehghan, A, Dhana, K, Di Castelnuovo, AF, Djalalinia, S, Doua, K, Drygas, W, Du, Y, Egbagbe, EE, Eggertsen, R, El Ati, J, Elosua, R, Erasmus, RT, Erem, C, Ergor, G, Eriksen, L, Escobedo-de la Peña, J, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrari, M, Ferreccio, C, Finn, JD, Föger, B, Foo, LH, Fouad, HM, Francis, DK, Franco Mdo, C, Frontera, G, Furusawa, T, Gaciong, Z, Galbarczyk, A, Garnett, SP, Gaspoz, JM, Gasull, M, Gates, L, Geleijnse, JM, Ghasemain, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Gonzalez Gross, M, González Rivas, JP, Gorbea, MB, Gottrand, F, Grant, JF, Grodzicki, T, Grøntved, A, Gruden, G, Gu, D, Guan, OP, Guerrero, R, Guessous, I, Guimaraes, AL, Gutierrez, L, Hardy, R, Hari Kumar, R, Heidemann, C, Hihtaniemi, IT, Ho, SY, Ho, SC, Hofman, A, Horimoto, AR, Hormiga, CM, Horta, BL, Houti, L, Hussieni, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikeda, N, Ikram, MA, Irazola, VE, Islam, M, Iwasaki, M, Jacobs, JM, Jafar, T, Jasienska, G, Jiang, CQ, Jonas, JB, Joshi, P, Kafatos, A, Kalter-Leibovici, O, Kasaeian, A, Katz, J, Kaur, P, Kavousi, M, Kelishadi, R, Kengne, AP, Kersting, M, Khader, YS, Kiechl, S, Kim, J, Kiyohara, Y, Kolsteren, P, Korrovits, P, Koskinen, S, Kratzer, W, Kromhout, D, Kula, K, Kurjata, P, Kyobutungi, C, Lachat, C, Laid, Y, Lam, TH, Lanska, V, Lappas, G, Laxmaiah, A, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Muñoz, LM, Li, Y, Lim, WY, Lima-Costa, MF, Lin, HH, Lin, X, Lissner, L, Lorbeer, R, Lozano, JE, Lundqvist, A, Lytsy, P, Ma, G, Machado-Coelho, GL, Machi, S, Maggi, S, Makdisse, M, Mallikharjuna v, K, Manios, Y, Manzato, E, Margozzini, P, Marques-Vidal, P, Martorell, R, Masoodi, SR, Matsha, TE, Mbanya, JC, McFarlane, SR, McGarvey, ST, McLachlan, S, McNulty, BA, Mediene-Benchekor, S, Meirhaeghe, A, Menezes, AM, Merat, S, Meshram, II, Mi, J, Miquel, JF, Mohamed, MK, Mohammad, K, Mohan, V, Mohd Yusoff, MF, Møller, NC, Molnar, D, Mondo, CK, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Muiesan, ML, Müller-Nurasyid, M, Mursu, J, Nagel, G, Námešná, J, Nang, EE, Nangia, VB, Navarrete-Muñoz, EM, Ndiaye, NC, Nervi, F, Nguyen, ND, Nieto-Martínez, RE, Alvarado, L, Ning, G, Ninomiya, T, Noale, M, Noto, D, Ochoa-Avilés, M, Oh, K, Onat, A, Osmond, C, Otero, JA, Palmieri, L, Panda-Jonas, S, Panza, F, Parsaeian, M, Peixoto, SV, Pereira, AC, Peters, A, Peykari, N, Pilav, A, Pitakaka, F, Piwonska, A, Piwonski, J, Plans-Rubió, P, Porta, M, Portegies, ML, Poustchi, H, Pradeepa, R, Price, JF, Punab, M, Qasrawi, RF, Qorbani, M, Raitakari, O, Ramachandra Rao, S, Ramachandran, A, Ramos, R, Rampal, S, Rathmann, W, Redon, J, Reganit, PF, Rigo, F, Robinson, SM, Robitaille, C, Rodríguez, LA, Rodríguez-Artalejo, F, del Cristo Rodriguez-Perez, M, Rojas-Martinez, R, Romaguera, D, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, Santos, RN, Santos, R, Sardinha, LB, Scazufca, M, Schargrodsky, H, Scheidt-Nave, C, Shibuya, K, Shin, Y, Shiri, R, Siantar, R, Sibai, AM, Simon, M, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Smeeth, L, Snijder, MB, Solfrizzi, V, Sonestedt, E, Soumare, A, Staessen, JA, Steene-Johannessen, J, Stehle, P, Stein, AD, Stessman, J, Stöckl, D, Stokwiszewski, J, Strufaldi, MW, Sun, CA, Sundström, J, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tarawneh, M, Tarqui-Mamani, CB, Thijs, L, Tolstrup, JS, Topbas, M, Torrent, M, Traissac, P, Trinh, OT, Tulloch-Reid, MK, Tuomainen, TP, Turley, ML, Tzourio, C, Ueda, P, Ukoli, FM, Ulmer, H, Valdivia, G, van Valkengoed, IG, Vanderschueren, D, Vanuzzo, D, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, M, Vioque, J, Virtanen, J, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Wade, AN, Wagner, A, Walton, J, Mohamud, WN, Wang, MD, Wang, YX, Wannamethee, SG, Weerasekera, D, Whincup, PH, Widhalm, K, Wiecek, A, Wilks, RJ, Willeit, J, Wojtyniak, B, Wong, TY, Woo, J, Woodward, M, Wu, AG, Wu, FC, Wu, SL, Xu, H, Yang, X, Ye, X, Yoshihara, A, Younger-Coleman, NO, Zambon, S, Zargar, AH, Zdrojewski, T, Zhao, W, and Zheng, Y
- Published
- 2015
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7. Dairy intake and risk of type 2 diabetes: results of a large prospective cohort
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Zhang, Shunming, primary, Meng, Ge, additional, Zhang, Qing, additional, Liu, Li, additional, Wu, Hongmei, additional, Gu, Yeqing, additional, Wang, Xuena, additional, Zhang, Juanjuan, additional, Sun, Shaomei, additional, Wang, Xing, additional, Zhou, Ming, additional, Jia, Qiyu, additional, Song, Kun, additional, Borné, Yan, additional, Sonestedt, E., additional, Ma, Le, additional, Qi, Lu, additional, and Niu, Kaijun, additional
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- 2023
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8. Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Fedirko, V., Trichopolou, A., Bamia, C., Duarte-Salles, T., Trepo, E., Aleksandrova, K., Nöthlings, U., Lukanova, A., Lagiou, P., Boffetta, P., Trichopoulos, D., Katzke, V.A., Overvad, K., Tjønneland, A., Hansen, L., Boutron-Ruault, M.C., Fagherazzi, G., Bastide, N., Panico, S., Grioni, S., Vineis, P., Palli, D., Tumino, R., Bueno-de-Mesquita, H.B., Peeters, P.H., Skeie, G., Engeset, D., Parr, C.L., Jakszyn, P., Sánchez, M.J., Barricarte, A., Amiano, P., Chirlaque, M., Quirós, J.R., Sund, M., Werner, M., Sonestedt, E., Ericson, U., Key, T.J., Khaw, K.T., Ferrari, P., Romieu, I., Riboli, E., and Jenab, M.
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- 2013
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9. Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort
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Botteri, E., Ferrari, P., Roswall, N., Tjønneland, A., Hjartåker, A., Huerta, J.M., Fortner, R.T., Trichopoulou, A., Karakatsani, A., La Vecchia, C., Pala, V., Perez‐Cornago, A., Sonestedt, E., Liedberg, F., Overvad, K, Sánchez, M.J., Gram, I.T., Stepien, M., Trijsburg, L., Börje, L., Johansson, M., Kühn, T., Panico, S., Tumino, R., Bueno‐de‐Mesquita, H. B(as), and Weiderpass, E.
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- 2017
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10. Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C
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Hellstrand, S., Sonestedt, E., Ericson, U., Gullberg, B., Wirfält, E., Hedblad, B., and Orho-Melander, M.
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- 2012
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11. A longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk
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Mayen, A, Viallon, V, Botteri, E, Proust-Lima, C, Bagnardi, V, Batista, V, Cross, A, Laouali, N, Macdonald, C, Severi, G, Katzke, V, Bergmann, M, Schulze, M, Tjonneland, A, Eriksen, A, Dahm, C, Antoniussen, C, Jakszyn, P, Sanchez, M, Amiano, P, Colorado-Yohar, S, Ardanaz, E, Travis, R, Palli, D, Sabina, S, Tumino, R, Ricceri, F, Panico, S, Bueno-de-Mesquita, B, Derksen, J, Sonestedt, E, Winkvist, A, Harlid, S, Braaten, T, Gram, I, Lukic, M, Jenab, M, Riboli, E, Freisling, H, Weiderpass, E, Gunter, M, Ferrari, P, Mayen, A, Viallon, V, Botteri, E, Proust-Lima, C, Bagnardi, V, Batista, V, Cross, A, Laouali, N, Macdonald, C, Severi, G, Katzke, V, Bergmann, M, Schulze, M, Tjonneland, A, Eriksen, A, Dahm, C, Antoniussen, C, Jakszyn, P, Sanchez, M, Amiano, P, Colorado-Yohar, S, Ardanaz, E, Travis, R, Palli, D, Sabina, S, Tumino, R, Ricceri, F, Panico, S, Bueno-de-Mesquita, B, Derksen, J, Sonestedt, E, Winkvist, A, Harlid, S, Braaten, T, Gram, I, Lukic, M, Jenab, M, Riboli, E, Freisling, H, Weiderpass, E, Gunter, M, and Ferrari, P
- Abstract
Background: Alcohol intake is an established risk factor for colorectal cancer (CRC); however, there is limited knowledge on whether changing alcohol drinking habits during adulthood modifies CRC risk. Objective: Leveraging longitudinal exposure assessments on alcohol intake at different ages, we examined the relationship between change in alcohol intake and subsequent CRC risk. Methods: Within the European Prospective Investigation into Cancer and Nutrition, changes in alcohol intake comparing follow-up with baseline assessments were investigated in relation to CRC risk. The analysis included 191,180, participants and 1530 incident CRC cases, with exclusion of the first three years of follow-up to minimize reverse causation. Trajectory profiles of alcohol intake, assessed at ages 20, 30, 40, 50 years, at baseline and during follow-up, were estimated using latent class mixed models and related to CRC risk, including 407,605 participants and 5,008 incident CRC cases. Results: Mean age at baseline was 50.2 years and the follow-up assessment occurred on average 7.1 years later. Compared to stable intake, a 12 g/day increase in alcohol intake during follow-up was positively associated with CRC risk (HR = 1.15, 95%CI 1.04, 1.25), while a 12 g/day reduction was inversely associated with CRC risk (HR = 0.86, 95%CI 0.78, 0.95). Trajectory analysis showed that compared to low alcohol intake, men who increased their alcohol intake from early- to mid- and late-adulthood by up to 30 g/day on average had significantly increased CRC risk (HR = 1.24; 95%CI 1.08, 1.42), while no associations were observed in women. Results were consistent by anatomical subsite. Conclusions: Increasing alcohol intake during mid-to-late adulthood raised CRC risk, while reduction lowered risk.
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- 2022
12. Milk intake and incident stroke and CHD in populations of European descent: A Mendelian randomisation study
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Cardiovasculaire Epi Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Public Health Practice, Public Health Epidemiologie, Vissers, L. E.T., Sluijs, I., Burgess, S., Forouhi, N. G., Freisling, H., Imamura, F., Nilsson, T. K., Renström, F., Weiderpass, E., Aleksandrova, K., Dahm, C. C., Perez-Cornago, A., Schulze, M. B., Tong, T. Y.N., Aune, D., Bonet, C., Boeing, H., Chirlaque, M. D., Conchi, M. I., Imaz, L., Jäger, S., Krogh, V., Kyrø, C., Masala, G., Melander, O., Overvad, K., Panico, S., Sánches, M. J., Sonestedt, E., Tjønneland, A., Tzoulaki, I., Verschuren, W. M.M., Riboli, E., Wareham, N. J., Danesh, J., Butterworth, A. S., Van Der Schouw, Y. T., Cardiovasculaire Epi Team 1, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Public Health Practice, Public Health Epidemiologie, Vissers, L. E.T., Sluijs, I., Burgess, S., Forouhi, N. G., Freisling, H., Imamura, F., Nilsson, T. K., Renström, F., Weiderpass, E., Aleksandrova, K., Dahm, C. C., Perez-Cornago, A., Schulze, M. B., Tong, T. Y.N., Aune, D., Bonet, C., Boeing, H., Chirlaque, M. D., Conchi, M. I., Imaz, L., Jäger, S., Krogh, V., Kyrø, C., Masala, G., Melander, O., Overvad, K., Panico, S., Sánches, M. J., Sonestedt, E., Tjønneland, A., Tzoulaki, I., Verschuren, W. M.M., Riboli, E., Wareham, N. J., Danesh, J., Butterworth, A. S., and Van Der Schouw, Y. T.
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- 2022
13. POS0559 COMPLIANCE WITH RECOMMENDATIONS OF LOW INTAKE OF RED MEAT AND HIGH FIBER INTAKE IS ASSOCIATED WITH A REDUCED RISK OF RHEUMATOID ARTHRITIS
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Bäcklund, R., primary, Drake, I., additional, Sonestedt, E., additional, Compagno, M., additional, Bergström, U., additional, and Turesson, C., additional
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- 2022
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14. Dietary Folate Intake and Breast Cancer Risk: European Prospective Investigation Into Cancer and Nutrition
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de Batlle, J., Ferrari, P., Chajes, V., Park, J. Y., Slimani, N., McKenzie, F., Overvad, K., Roswall, N., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, G., Katzke, V., Kaaks, R., Bergmann, M. M., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Peeters, P. H., Hjartåker, A., Engeset, D., Weiderpass, E., Sánchez, S., Travier, N., Sánchez, M. J., Amiano, P., Chirlaque, M. D., Barricarte Gurrea, A., Khaw, K. T., Key, T. J., Bradbury, K. E., Ericson, U., Sonestedt, E., Van Guelpen, B., Schneede, J., Riboli, E., and Romieu, I.
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- 2015
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15. Milk intake and incident stroke and coronary heart disease in populations of European descent: A Mendelian Randomization study
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Vissers, L.E.T., Sluijs, I., Burgess, S., Forouhi, N.G., Freisling, H., Imamura, F., Nilsson, Torbjörn K., Renström, Frida, Weiderpass, E., Aleksandrova, K., Dahm, C.C., Perez-Cornago, A., Schulze, M.B., Tong, T.Y.N., Aune, D., Bonet, C., Boer, J.M.A., Boeing, H., Chirlaque, M.D., Conchi, M.I., Imaz, L., Jäger, S., Krogh, V., Kyrø, C., Masala, G., Melander, O., Overvad, K., Panico, S., Sánches, M.J., Sonestedt, E., Tjønneland, A., Tzoulaki, I., Verschuren, W.M.M., Riboli, E., Wareham, N.J., Danesh, J., Butterworth, A.S., and Van Der Schouw, Y.T.
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Näringslära ,Nutrition and Dietetics ,CHD ,Milk ,Mendelian Randomization ,dairy ,stroke - Abstract
Higher milk intake has been associated with a lower stroke risk, but not with risk of coronary heart disease (CHD). Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with stroke and CHD risk through instrumental variable (IV) and gene-outcome analyses. IV analysis included 29,328 participants (4,611 stroke; 9,828 CHD) of the EPIC-CVD (8 European countries) and EPIC-NL case-cohort studies. rs4988235, a lactase persistence (LP) single nucleotide polymorphism which enables digestion of lactose in adulthood was used as genetic instrument. Intake of milk was first regressed on rs4988235 in a linear regression model. Next, associations of genetically predicted milk consumption with stroke and CHD were estimated using Prentice-weighted Cox regression. Gene-outcome analysis included 777,024 participants (50,804 cases) from MEGASTROKE (including EPIC-CVD), UK Biobank and EPIC-NL for stroke, and 483,966 participants (61,612 cases) from CARDIoGRAM, UK Biobank and EPIC-CVD and EPIC-NL for CHD. In IV analyses, each additional LP allele was associated with a higher intake of milk in EPIC-CVD (β=13.7 g/day; 95%CI: 8.4-19.1) and EPIC-NL (36.8 g/day; 20.0-53.5). Genetically predicted milk intake was not associated with stroke (HR per 25 g/day 1.05; 95%CI: 0.94-1.16) or CHD (1.02; 0.96-1.08). In gene-outcome analyses, there was no association of rs4988235 with risk of stroke (odds ratios 1.02; 0.99-1.05) or CHD (0.99; 0.95-1.03). Current Mendelian Randomization analysis does not provide evidence for a causal inverse relationship between milk consumption and stroke or CHD risk. MEGASTROKE
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- 2021
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16. Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults
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Zimmermann, E., Ängquist, L. H., Mirza, S. S., Zhao, J. H., Chasman, D. I., Fischer, K., Qi, Q., Smith, A. V., Thinggaard, M., Jarczok, M. N., Nalls, M. A., Trompet, S., Timpson, N. J., Schmidt, B., Jackson, A. U., Lyytikäinen, L. P., Verweij, N., Mueller-Nurasyid, M., Vikström, M., Marques-Vidal, P., Wong, A., Meidtner, K., Middelberg, R. P., Strawbridge, R. J., Christiansen, L., Kyvik, K. O., Hamsten, A., Jääskeläinen, T., Tjnneland, A., Eriksson, J. G., Whitfield, J. B., Boeing, H., Hardy, R., Vollenweider, P., Leander, K., Peters, A., van der Harst, P., Kumari, M., Lehtimäki, T., Meirhaeghe, A., Tuomilehto, J., Jöckel, K.-H., Ben-Shlomo, Y., Sattar, N., Baumeister, S. E., Davey Smith, G., Casas, J. P., Houston, D. K., März, W., Christensen, K., Gudnason, V., Hu, F. B., Metspalu, A., Ridker, P. M., Wareham, N. J., Loos, R. J. F., Tiemeier, H., Sonestedt, E., and Srensen, T. I. A.
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- 2015
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17. Milk intake and incident stroke and CHD in populations of European descent: a Mendelian randomisation study
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Vissers, L. E. T., primary, Sluijs, I., additional, Burgess, S., additional, Forouhi, N. G., additional, Freisling, H., additional, Imamura, F., additional, Nilsson, T. K., additional, Renström, F., additional, Weiderpass, E., additional, Aleksandrova, K., additional, Dahm, C. C., additional, Perez-Cornago, A., additional, Schulze, M. B., additional, Tong, T. Y. N., additional, Aune, D., additional, Bonet, C., additional, Boer, J. M. A., additional, Boeing, H., additional, Chirlaque, M. D., additional, Conchi, M. I., additional, Imaz, L., additional, Jäger, S., additional, Krogh, V., additional, Kyrø, C., additional, Masala, G., additional, Melander, O., additional, Overvad, K., additional, Panico, S., additional, Sánches, M. J., additional, Sonestedt, E., additional, Tjønneland, A., additional, Tzoulaki, I., additional, Verschuren, W. M. M., additional, Riboli, E., additional, Wareham, N. J., additional, Danesh, J., additional, Butterworth, A. S., additional, and van der Schouw, Y. T., additional
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- 2021
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18. Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes
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Hindy, G., Sonestedt, E., Ericson, U., Jing, X.-J., Zhou, Y., Hansson, O., Renström, E., Wirfält, E., and Orho-Melander, M.
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- 2012
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19. Dietary intakes and food sources of phytoestrogens in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24-hour dietary recall cohort
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Zamora-Ros, R, Knaze, V, Luján-Barroso, L, Kuhnle, G G C, Mulligan, A A, Touillaud, M, Slimani, N, Romieu, I, Powell, N, Tumino, R, Peeters, P H M, de Magistris, M S, Ricceri, F, Sonestedt, E, Drake, I, Hjartåker, A, Skie, G, Mouw, T, Wark, P A, Romaguera, D, Bueno-de-Mesquita, H B, Ros, M, Molina, E, Sieri, S, Quirós, J R, Huerta, J M, Tjønneland, A, Halkjær, J, Masala, G, Teucher, B, Kaas, R, Travis, R C, Dilis, V, Benetou, V, Trichopoulou, A, Amiano, P, Ardanaz, E, Boeing, H, Förster, J, Clavel-Chapelon, F, Fagherazzi, G, Perquier, F, Johansson, G, Johansson, I, Cassidy, A, Overvad, K, and González, C A
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- 2012
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20. Food intake of individuals with and without diabetes across different countries and ethnic groups
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Nöthlings, U, Boeing, H, Maskarinec, G, Sluik, D, Teucher, B, Kaaks, R, Tjønneland, A, Halkjaer, J, Dethlefsen, C, Overvad, K, Amiano, P, Toledo, E, Bendinelli, B, Grioni, S, Tumino, R, Sacerdote, C, Mattiello, A, Beulens, J W J, Iestra, J A, Spijkerman, A M W, van der A, D L, Nilsson, P, Sonestedt, E, Rolandsson, O, Franks, P W, Vergnaud, A-C, Romaguera, D, Norat, T, and Kolonel, L N
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- 2011
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21. Dietary glycaemic index and glycaemic load in the European Prospective Investigation into Cancer and Nutrition
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van Bakel, M.M.E., Kaaks, R., Feskens, E.J.M., Rohrmann, S., Welch, A.A., Pala, V., Avloniti, K., van der Schouw, Y.T., van der A, D.L., Du, H., Halkjaer, J., Tormo, M.J., Cust, A.E., Brighenti, F., Beulens, J.W., Ferrari, P., Biessy, C., Lentjes, M., Spencer, E.A., Panico, S., Masala, G., Bueno-de-Mesquita, H.B., Peeters, P.H.M., Trichopoulou, A., Psaltopoulou, T., Clavel-Chapelon, F., Touvier, M., Skeie, G., Rinaldi, S., Sonestedt, E., Johansson, I., Schulze, M., Ardanaz, E., Buckland, G., Tjonneland, A., Overvad, K., Bingham, S., Riboli, E., and Slimani, N.
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Carbohydrates -- Nutritional aspects -- Identification and classification -- Research ,Sugars in human nutrition -- Research -- Nutritional aspects ,Cancer -- Research -- Nutritional aspects ,Glycemic index -- Research -- Nutritional aspects ,Food/cooking/nutrition ,Health - Abstract
Objectives: To describe dietary glycaemic index (GI) and glycaemic load (GL) values in the population participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study according to food groups, nutrients and lifestyle characteristics. Methods: Single 24-h dietary recalls (24-HDRs) from 33 566 subjects were used to calculate dietary GI and GL, and an ad hoc database was created as the main reference source. Mean GI and GL intakes were adjusted for age, total energy intake, height and weight, and were weighted by season and day of recall. Results: GI was the lowest in Spain and Germany, and highest in the Netherlands, United Kingdom and Denmark for both genders. In men, GL was the lowest in Spain and Germany and highest in Italy, whereas in women, it was the lowest in Spain and Greece and highest in the UK health-conscious cohort. Bread was the largest contributor to GL in all centres (15-45%), but it also showed the largest inter-individual variation. GL, but not GI, tended to be lower in the highest body mass index category in both genders. GI was positively correlated with starch and intakes of bread and potatoes, whereas it was correlated negatively with intakes of sugar, fruit and dairy products. GL was positively correlated with all carbohydrate components and intakes of cereals, whereas it was negatively correlated with fat and alcohol and with intakes of wine, with large variations across countries. Conclusions: GI means varied modestly across countries and genders, whereas GL means varied more, but it may possibly act as a surrogate of carbohydrate intake. doi: 10.1038/ejcn.2009.81 Keywords: glycaemic index; glycaemic load; 24-h dietary recall; EPIC; ENDB; standardization, Introduction Carbohydrates are traditionally classified according to their saccharide chain length as 'simple sugar' or 'complex carbohydrate'. However, Jenkins et al. (1981) developed a more physiological classification on the basis [...]
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- 2009
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22. Dietary fat intake in the European Prospective Investigation into Cancer and Nutrition: results from the 24-h dietary recalls
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Linseisen, J., Welch, A.A., Ocke, M., Amiano, P., Agnoli, C., Ferrari, P., Sonestedt, E., Chajes, V., Bueno-de-Mesquita, H.B., Kaaks, R., Weikert, C., Dorronsoro, M., Rodriguez, L., Ermini, I., Mattiello, A., van der Schouw, Y.T., Manjer, J., Nilsson, S., Jenab, M., Lund, E., Brustad, M., Halkjaer, J., Jakobsen, M.U., Khaw, K.T., Crowe, F., Georgila, C., Misirli, G., Niravong, M., Touvier, M., Bingham, S., Riboli, E., and Slimani, N.
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Cholesterol -- Health aspects ,Dietary fat -- Health aspects ,Cancer -- Risk factors ,Diet -- Health aspects ,Food/cooking/nutrition ,Health - Abstract
Objectives: This paper describes the dietary intake of total fat, saturated (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA) and cholesterol of participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) in 27 centres across 10 countries. Methods: Between 1995 and 2000, a stratified random sample of 36 034 participants (age range 35-74 years) completed a standardized 24-h dietary recall, assessed by means of the computer software EPIC-SOFT. Lipid intake data were calculated using a standardized nutrient database. Results: On average, the contribution of fat to total energy intake was ≥ 34% of energy intake (%en) in women and ≥ 36%en in men for most EPIC centres, except for the British, Dutch and most Italian cohorts. Total fat (440%en) and MUFA intakes (21%en, mainly from olive oil) were highest in Greece. Except for the Greek, Spanish and Italian centres, the average MUFA intake ranged between 10 and 13%en, with a high proportion derived from animal sources. SFA intake in women and men was lowest in the Greek, Spanish, Italian and UK cohorts with an average of ≤ 13%en (down to 9%en), and highest in the Swedish centres (16%en). The mean PUFA intake was in the range of 4-8%en, being highest in the UK health-conscious cohort. The average cholesterol intake across EPIC varied from 140 to 384 mg/d in women and 215-583 mg/d in men. Conclusions: The presented data show differences and similarities in lipid intake across the European EPIC cohorts and also show differences in food sources of dietary lipids. doi: 10.1038/ejcn.2009.75 Keywords: EPIC; 24-h diet recalls; dietary intake; lipids; EPIC-Soft; ENDB, Introduction Diet has a major impact on modulating the risk and severity of a number of chronic diseases including obesity and obesity-related metabolic disorders, cardiovascular diseases and cancer. Among macronutrients, [...]
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- 2009
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23. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
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Zhou, B, Carrillo-Larco, Rm, Danaei, G, Riley, Lm, Paciorek, Cj, Stevens, Ga, Gregg, Ew, Bennett, Je, Solomon, B, Singleton, Rk, Sophiea, Mk, Iurilli, Mlc, Lhoste, Vpf, Cowan, Mj, Savin, S, Woodward, M, Balanova, Y, Cifkova, R, Damasceno, A, Elliott, P, Farzadfar, F, He, J, Ikeda, N, Kengne, Ap, Khang, Yh, Kim, Hc, Laxmaiah, A, Lin, Hh, Maira, Pm, Miranda, Jj, Neuhauser, H, Sundstrom, J, Varghese, C, Widyahening, Is, Zdrojewski, T, Ezzati, M, Abarca-Gomez, L, Abdeen, Za, Rahim, Hfa, Abu-Rmeileh, Nm, Acosta-Cazares, B, Adams, Rj, Aekplakorn, W, Afsana, K, Afzal, S, Agdeppa, Ia, Aghazadeh-Attari, J, Aguilar-Salinas, Ca, Agyemang, C, Ahmad, Na, Ahmadi, A, Ahmadi, N, Ahmadizar, F, Ahmed, Sh, Ahrens, W, Ajlouni, K, Al-Raddadi, R, Alarouj, M, Albuhairan, F, Aldhukair, S, Ali, Mm, Alkandari, A, Alkerwi, A, Allin, K, Aly, E, Amarapurkar, Dn, Amougou, N, Amouyel, P, Andersen, Lb, Anderssen, Sa, Anjana, Rm, Ansari-Moghaddam, A, Ansong, D, Aounallah-Skhiri, H, Araujo, J, Ariansen, I, Aris, T, Arku, Re, Arlappa, N, Aryal, Kk, Aspelund, T, Assah, Fk, Assuncao, Mcf, Auvinen, J, Avdicova, M, Azevedo, A, Azimi-Nezhad, M, Azizi, F, Azmin, M, Babu, Bv, Bahijri, S, Balakrishna, N, Bamoshmoosh, M, Banach, M, Banadinovic, M, Bandosz, P, Banegas, Jr, Baran, J, Barbagallo, Cm, Barcelo, A, Barkat, A, Barreto, M, Barros, Ajd, Barros, Mvg, Bartosiewicz, A, Basit, A, Bastos, Jld, Bata, I, Batieha, Am, Batyrbek, A, Baur, La, Beaglehole, R, Belavendra, A, Ben Romdhane, H, Benet, M, Benson, Ls, Berkinbayev, S, Bernabe-Ortiz, A, Bettiol, H, Bezerra, J, Bhagyalaxmi, A, Bhargava, Sk, Bia, D, Biasch, K, Lele, Ecb, Bikbov, Mm, Bista, B, Bjerregaard, P, Bjertness, E, Bjertness, Mb, Bjorkelund, C, Bloch, Kv, Blokstra, A, Bo, S, Bobak, M, Boeing, H, Boggia, Jg, Boissonnet, Cp, Bojesen, Se, Bongard, V, Bonilla-Vargas, A, Bopp, M, Borghs, H, Bovet, P, Boyer, Cb, Braeckman, L, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, Lm, Briceno, Y, Brito, M, Bruno, G, Bueno-de-Mesquita, Hb, Bueno, G, Bugge, A, Burns, C, Bursztyn, M, de Leon, Ac, Cacciottolo, J, Cameron, C, Can, G, Candido, Apc, Capanzana, Mv, Capkova, N, Capuano, E, Capuano, V, Cardoso, Vc, Carlsson, Ac, Carvalho, J, Casanueva, Ff, Censi, L, Cervantes-Loaiza, M, Chadjigeorgiou, Ca, Chamukuttan, S, Chan, Aw, Chan, Q, Chaturvedi, Hk, Chaturvedi, N, Chee, Ml, Chen, Cj, Chen, Ff, Chen, Hs, Chen, Sh, Chen, Zm, Cheng, Cy, Cheraghian, B, Dekkaki, Ic, Chetrit, A, Chien, Kl, Chiolero, A, Chiou, St, Chirita-Emandi, A, Chirlaque, Md, Cho, B, Christensen, K, Christofaro, Dg, Chudek, J, Cinteza, E, Claessens, F, Clarke, J, Clays, E, Cohen, E, Concin, H, Cooper, C, Coppinger, Tc, Costanzo, S, Cottel, D, Cowell, C, Craig, Cl, Crampin, Ac, Crujeiras, Ab, Cruz, Jj, Csilla, S, Cui, Lf, Cureau, Fv, Cuschieri, S, D'Arrigo, G, D'Orsi, E, Dallongeville, J, Dankner, R, Dantoft, Tm, Dauchet, L, Davletov, K, De Backer, G, De Bacquer, D, De Curtis, A, de Gaetano, G, De Henauw, S, de Oliveira, Pd, De Ridder, D, De Smedt, D, Deepa, M, Deev, Ad, Degennaro, V, Delisle, H, Demarest, S, Dennison, E, Deschamps, V, Dhimal, M, Di Castelnuovo, Af, Dias-da-Costa, Js, Diaz, A, Dickerson, Tt, Dika, Z, Djalalinia, S, Htp, Do, Dobson, Aj, Donfrancesco, C, Donoso, Sp, Doring, A, Dorobantu, M, Dorr, M, Doua, K, Dragano, N, Drygas, W, Duante, Ca, Duboz, P, Duda, Rb, Dulskiene, V, Dushpanova, A, Dzakula, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Eddie, R, Eftekhar, E, Eggertsen, R, Eghtesad, S, Eiben, G, Ekelund, U, El-Khateeb, M, El Ati, J, Eldemire-Shearer, D, Eliasen, M, Elosua, R, Erasmus, Rt, Erbel, R, Erem, C, Eriksen, L, Eriksson, Jg, Escobedo-de la Pena, J, Eslami, S, Esmaeili, A, Evans, A, Faeh, D, Fakhretdinova, Aa, Fall, Ch, Faramarzi, E, Farjam, M, Fattahi, Mr, Fawwad, A, Felix-Redondo, Fj, Felix, Sb, Ferguson, Ts, Fernandes, Ra, Fernandez-Berges, D, Ferrante, D, Ferrao, T, Ferrari, M, Ferrario, Mm, Ferreccio, C, Ferreira, Hs, Ferrer, E, Ferrieres, J, Figueiro, Th, Fink, G, Fischer, K, Foo, Lh, Forsner, M, Fouad, Hm, 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Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Clinicum, Research Programs Unit, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, University of Helsinki, HUS Helsinki and Uusimaa Hospital District, Department of Public Health, Tampere University, Clinical Medicine, Department of Clinical Chemistry, Eye Centre, Wellcome Trust, Epidemiology, Radiology & Nuclear Medicine, Éco-Anthropologie (EA), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Université Paris Cité (UPCité), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Epidemiology and Data Science, APH - Aging & Later Life, APH - Societal Participation & Health, Public and occupational health, APH - Health Behaviors & Chronic Diseases, VU University medical center, APH - Personalized Medicine, Psychiatry, APH - Mental Health, Bin Zhou, Rodrigo M Carrillo-Larco, Goodarz Danaei, Leanne M Riley, Christopher J Paciorek, Gretchen A Stevens, Edward W Gregg, James E Bennett, Bethlehem Solomon, Rosie K Singleton, Marisa K Sophiea, Maria Lc Iurilli, Victor Pf Lhoste, Melanie J Cowan, Stefan Savin, Mark Woodward, Yulia Balanova, Renata Cifkova, Albertino Damasceno, Paul Elliott, Farshad Farzadfar, Jiang He, Nayu Ikeda, Andre P Kengne, Young-Ho Khang, Hyeon Chang Kim, Avula Laxmaiah, Hsien-Ho Lin, Paula Margozzini Maira, J Jaime Miranda, Hannelore Neuhauser, Johan Sundström, Cherian Varghese, Indah S Widyahening, Tomasz Zdrojewski, Leandra Abarca-Gómez, Ziad A Abdeen, Hanan F Abdul Rahim, Niveen M Abu-Rmeileh, Benjamin Acosta-Cazares, Robert J Adams, Wichai Aekplakorn, Kaosar Afsana, Shoaib Afzal, Imelda A 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Burns, Michael Bursztyn, Antonio Cabrera de León, Joseph Cacciottolo, Christine Cameron, Günay Can, Ana Paula C Cândido, Mario V Capanzana, Naděžda Čapková, Eduardo Capuano, Vincenzo Capuano, Viviane C Cardoso, Axel C Carlsson, Joana Carvalho, Felipe F Casanueva, Laura Censi, Marvin Cervantes-Loaiza, Charalambos A Chadjigeorgiou, Snehalatha Chamukuttan, Angelique W Chan, Queenie Chan, Himanshu K Chaturvedi, Nish Chaturvedi, Miao Li Chee, Chien-Jen Chen, Fangfang Chen, Huashuai Chen, Shuohua Chen, Zhengming Chen, Ching-Yu Cheng, Bahman Cheraghian, Imane Cherkaoui Dekkaki, Angela Chetrit, Kuo-Liong Chien, Arnaud Chiolero, Shu-Ti Chiou, Adela Chirita-Emandi, María-Dolores Chirlaque, Belong Cho, Kaare Christensen, Diego G Christofaro, Jerzy Chudek, Eliza Cinteza, Frank Claessens, Janine Clarke, Els Clays, Emmanuel Cohen, Hans Concin, Cyrus Cooper, Tara C Coppinger, Simona Costanzo, Dominique Cottel, Chris Cowell, Cora L Craig, Amelia C Crampin, Ana B Crujeiras, Juan J Cruz, Semánová 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Andre L Guimaraes, Martin C Gulliford, Johanna Gunnlaugsdottir, Marc J Gunter, Prakash C Gupta, Rajeev Gupta, Oye Gureje, Beata Gurzkowska, Laura Gutierrez, Felix Gutzwiller, Seongjun Ha, Farzad Hadaegh, Rosa Haghshenas, Hamid Hakimi, Jytte Halkjær, Ian R Hambleton, Behrooz Hamzeh, Dominique Hange, Abu Am Hanif, Sari Hantunen, Jie Hao, Carla Menêses Hardman, Rachakulla Hari Kumar, Seyed Mohammad Hashemi-Shahri, Jun Hata, Teresa Haugsgjerd, Alison J Hayes, Yuna He, Margit Heier, Marleen Elisabeth Hendriks, Rafael Dos Santos Henrique, Ana Henriques, Leticia Hernandez Cadena, Herqutanto, Sauli Herrala, Ramin Heshmat, Allan G Hill, Sai Yin Ho, Suzanne C Ho, Michael Hobbs, Michelle Holdsworth, Reza Homayounfar, Gonul Horasan Dinc, Andrea Rvr Horimoto, Claudia M Hormiga, Bernardo L Horta, Leila Houti, Christina Howitt, Thein Thein Htay, Aung Soe Htet, Maung Maung Than Htike, Yonghua Hu, José María Huerta, Ilpo Tapani Huhtaniemi, Laetitia Huiart, Martijn Huisman, Abdullatif S Husseini, Inge Huybrechts, Nahla Hwalla, Licia Iacoviello, Anna G Iannone, Mohsen M Ibrahim, Norazizah Ibrahim Wong, M Arfan Ikram, Violeta Iotova, Vilma E Irazola, Takafumi Ishida, Godsent C Isiguzo, Muhammad Islam, Sheikh Mohammed Shariful Islam, Masanori Iwasaki, Rod T Jackson, Jeremy M Jacobs, Hashem Y Jaddou, Tazeen Jafar, Kenneth James, Konrad Jamrozik, Imre Janszky, Edward Janus, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelaković, Bojan Jelaković, Garry Jennings, Anjani Kumar Jha, Chao Qiang Jiang, Ramon O Jimenez, Karl-Heinz Jöckel, Michel Joffres, Mattias Johansson, Jari J Jokelainen, Jost B Jonas, Torben Jørgensen, Pradeep Joshi, Farahnaz Joukar, Jacek Jóżwiak, Anne Juolevi, Gregor Jurak, Vesna Jureša, Rudolf Kaaks, Anthony Kafatos, Eero O Kajantie, Zhanna Kalmatayeva, Natasa Kalpourtzi, Ofra Kalter-Leibovici, Freja B Kampmann, Srinivasan Kannan, Eva Karaglani, Line L Kårhus, Khem B Karki, Marzieh Katibeh, Joanne Katz, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli M Kazakbaeva, Ulrich Keil, Lital Keinan Boker, Sirkka Keinänen-Kiukaanniemi, Roya Kelishadi, Han Cg Kemper, Maryam Keramati, Alina Kerimkulova, Mathilde Kersting, Timothy Key, Yousef Saleh Khader, Davood Khalili, Kay-Tee Khaw, Bahareh Kheiri, Motahareh Kheradmand, Alireza Khosravi, Ursula Kiechl-Kohlendorfer, Stefan Kiechl, Japhet Killewo, Dong Wook Kim, Jeongseon Kim, Heidi Klakk, Magdalena Klimek, Jurate Klumbiene, Michael Knoflach, Elin Kolle, Patrick Kolsteren, Jukka P Kontto, Raija Korpelainen, Paul Korrovits, Jelena Kos, Seppo Koskinen, Katsuyasu Kouda, Sudhir Kowlessur, Slawomir Koziel, Jana Kratenova, Vilma Kriaucioniene, Peter Lund Kristensen, Steiner Krokstad, Daan Kromhout, Herculina S Kruger, Ruzena Kubinova, Renata Kuciene, Urho M Kujala, Zbigniew Kulaga, R Krishna Kumar, Pawel Kurjata, Yadlapalli S Kusuma, Vladimir Kutsenko, Kari Kuulasmaa, Catherine Kyobutungi, Tiina Laatikainen, Carl Lachat, Youcef Laid, Tai Hing Lam, Orlando Landrove, Vera Lanska, Georg Lappas, Bagher Larijani, Tint Swe Latt, Gwenaëlle Le Coroller, Khanh Le Nguyen Bao, Tuyen D Le, Jeannette Lee, Jeonghee Lee, Nils Lehmann, Terho Lehtimäki, Daniel Lemogoum, Naomi S Levitt, Yanping Li, Christa L Lilly, Wei-Yen Lim, M Fernanda Lima-Costa, Xu Lin, Yi-Ting Lin, Lars Lind, Vijaya Lingam, Allan Linneberg, Lauren Lissner, Mieczyslaw Litwin, Wei-Cheng Lo, Helle-Mai Loit, Esther Lopez-Garcia, Tania Lopez, Paulo A Lotufo, José Eugenio Lozano, Iva Lukačević Lovrenčić, Janice L Lukrafka, Dalia Luksiene, Annamari Lundqvist, Robert Lundqvist, Nuno Lunet, Michala Lustigová, Edyta Luszczki, Guansheng Ma, Jun Ma, George Ll Machado-Coelho, Aristides M Machado-Rodrigues, Enguerran Macia, Luisa M Macieira, Ahmed A Madar, Stefania Maggi, Dianna J Magliano, Emmanuella Magriplis, Gowri Mahasampath, Bernard Maire, Marjeta Majer, Marcia Makdisse, Fatemeh Malekzadeh, Reza Malekzadeh, Rahul Malhotra, Kodavanti Mallikharjuna Rao, Sofia K Malyutina, Lynell V Maniego, Yannis Manios, Jim I Mann, Fariborz Mansour-Ghanaei, Enzo Manzato, Anie Marcil, Staffan B Mårild, Mihalea Marinović Glavić, Pedro Marques-Vidal, Larissa Pruner Marques, Jaume Marrugat, Reynaldo Martorell, Luis P Mascarenhas, Marija Matasin, Ellisiv B Mathiesen, Prashant Mathur, Alicia Matijasevich, Piotr Matlosz, Tandi E Matsha, Christina Mavrogianni, Jean Claude N Mbanya, Anselmo J Mc Donald Posso, Shelly R McFarlane, Stephen T McGarvey, Stela McLachlan, Rachael M McLean, Scott B McLean, Breige A McNulty, Sounnia Mediene Benchekor, Jurate Medzioniene, Parinaz Mehdipour, Kirsten Mehlig, Amir Houshang Mehrparvar, Aline Meirhaeghe, Christa Meisinger, Carlos Mendoza Montano, Ana Maria B Menezes, Geetha R Menon, Alibek Mereke, Indrapal I Meshram, Andres Metspalu, Haakon E Meyer, Jie Mi, Nathalie Michels, Kairit Mikkel, Karolina Milkowska, Jody C Miller, Cláudia S Minderico, G K Mini, Mohammad Reza Mirjalili, Erkin Mirrakhimov, Marjeta Mišigoj-Duraković, Pietro A Modesti, Sahar Saeedi Moghaddam, Bahram Mohajer, Mostafa K Mohamed, Shukri F Mohamed, Kazem Mohammad, Mohammad Reza Mohammadi, Zahra Mohammadi, Noushin Mohammadifard, Reza Mohammadpourhodki, Viswanathan Mohan, Salim Mohanna, Muhammad Fadhli Mohd Yusoff, Iraj Mohebbi, Farnam Mohebi, Marie Moitry, Line T Møllehave, Dénes Molnár, Amirabbas Momenan, Charles K Mondo, Eric Monterrubio-Flores, Kotsedi Daniel K Monyeki, Jin Soo Moon, Mahmood Moosazadeh, Leila B Moreira, Alain Morejon, Luis A Moreno, Karen Morgan, George Moschonis, Malgorzata Mossakowska, Aya Mostafa, Seyed-Ali Mostafavi, Jorge Mota, Mohammad Esmaeel Motlagh, Jorge Motta, Marcos André Moura-Dos-Santos, Malay K Mridha, Kelias P Msyamboza, Thet Thet Mu, Alfa J Muhihi, Maria L Muiesan, Martina Müller-Nurasyid, Neil Murphy, Jaakko Mursu, Kamarul Imran Musa, Sanja Musić Milanović, Vera Musil, Norlaila Mustafa, Iraj Nabipour, Shohreh Naderimagham, Gabriele Nagel, Balkish M Naidu, Farid Najafi, Harunobu Nakamura, Jana Námešná, Ei Ei K Nang, Vinay B Nangia, Sameer Narake, Ndeye Coumba Ndiaye, 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D. A., Peres, Marco A., Peters, Annette, Petkeviciene, Janina, Peykari, Niloofar, Son Thai Pham, Pichardo, Rafael N., Pigeot, Iris, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pitakaka, Freda, Piwonska, Aleksandra, Pizarro, Andreia N., Plans-Rubio, Pedro, Polasek, Ozren, Porta, Miquel, Poudyal, Anil, Pourfarzi, Farhad, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Price, Alison J., Price, Jacqueline F., Providencia, Rui, Puhakka, Soile E., Puiu, Maria, Punab, Margus, Qasrawi, Radwan F., Qorbani, Mostafa, Queiroz, Daniel, Tran Quoc Bao, Radic, Ivana, Radisauskas, Ricardas, Rahimikazerooni, Salar, Rahman, Mahfuzar, Raitakari, Olli, Raj, Manu, Rakhimova, Ellina M., Rao, Sudha Ramachandra, Ramachandran, Ambady, Ramos, Elisabete, Rampal, Lekhraj, Rampal, Sanjay, Rangel Reina, Daniel A., Rarra, Vayia, Rech, Cassiano Ricardo, Redon, Josep, Reganit, Paul Ferdinand M., Regecova, Valeria, Revilla, Luis, Rezaianzadeh, Abbas, Ribeiro, Robespierre, Riboli, Elio, Richter, Adrian, Rigo, Fernando, de Wit, Tobias F. Rinke, Ritti-Dias, Raphael M., Robitaille, Cynthia, Rodriguez-Artalejo, Fernando, del Cristo Rodriguez-Perez, Maria, Rodriguez-Villamizar, Laura A., Roggenbuck, Ulla, Rojas-Martinez, Rosalba, Romaguera, Dora, Romeo, Elisabetta L., Rosengren, Annika, Roy, Joel G. R., Rubinstein, Adolfo, Ruidavets, Jean-Bernard, Sandra Ruiz-Betancourt, Blanca, Ruiz-Castell, Maria, Rusakova, Iuliia A., Russo, Paola, Rutkowski, Marcin, Sabanayagam, Charumathi, Sabbaghi, Hamideh, Sachdev, Harshpal S., Sadjadi, Alireza, Safarpour, Ali Reza, Safi, Sare, Safiri, Saeid, Saidi, Olfa, Saki, Nader, Salanave, Benoit, Salazar Martinez, Eduardo, Salmeron, Diego, Salomaa, Veikko, Salonen, Jukka T., Salvetti, Massimo, Sanchez-Abanto, Jose, Sans, Susana, Santos, Diana A., Santos, Ina S., Santos, Lelita C., Santos, Maria Paula, Santos, Rute, Saramies, Jouko L., Sardinha, Luis B., Sarganas, Giselle, Sarrafzadegan, Nizal, Sathish, Thirunavukkarasu, Saum, Kai-Uwe, Savva, Savvas, Sawada, Norie, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D., Schargrodsky, Herman, Schipf, Sabine, Schmidt, Carsten O., Schnohr, Peter, Schoettker, Ben, Schramm, Sara, Schultsz, Constance, Schutte, Aletta E., Sebert, Sylvain, Sein, Aye Aye, Sen, Abhijit, Senbanjo, Idowu O., Sepanlou, Sadaf G., Servais, Jennifer, Shalnova, Svetlana A., Shamah-Levy, Teresa, Shamshirgaran, Morteza, Shanthirani, Coimbatore Subramaniam, Sharafkhah, Maryam, Sharma, Sanjib K., Shaw, Jonathan E., Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shi, Zumin, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shin, Dong Wook, Shirani, Majid, Shiri, Rahman, Shrestha, Namuna, Si-Ramlee, Khairil, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M., de Moura Silva, Caroline Ramos, Santos Silva, Diego Augusto, Simon, Mary, Simons, Judith, Simons, Leon A., Sjostrom, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, So, Hung-Kwan, Soares, Fernanda Cunha, Sobngwi, Eugene, Soderberg, Stefan, Soemantri, Agustinus, Sofat, Reecha, Solfrizzi, Vincenzo, Somi, Mohammad Hossein, Sonestedt, Emily, Song, Yi, Sorensen, Thorkild I. 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Goya, Wareham, Nicholas, Wei, Wenbin, Weres, Aneta, Werner, Bo, Whincup, Peter H., Widhalm, Kurt, Wiecek, Andrzej, Wilks, Rainford J., Willeit, Johann, Willeit, Peter, Williams, Emmanuel A., Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A., Wong, Andrew, Wong, Tien Yin, Woo, Jean, Wu, Frederick C., Wu, Shouling, Wyszynska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yasuharu, Tabara, Ye, Xingwang, Yiallouros, Panayiotis K., Yoosefi, Moein, Yoshihara, Akihiro, You, San-Lin, Younger-Coleman, Novie O., Yusoff, Ahmad Faudzi, Zainuddin, Ahmad A., Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Elisa Zapata, Maria, Zaw, Ko Ko, Zejglicova, Kristyna, Vrkic, Tajana Zeljkovic, Zeng, Yi, Zhang, Luxia, Zhao, Dong, Zhao, Ming-Hui, Zhen, Shiqi, Zheng, Yingfeng, Zholdin, Bekbolat, Zhu, Dan, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuniga Cisneros, Julio., School of Medicine, ACS - Diabetes & metabolism, APH - Global Health, Pulmonology, Medical Informatics, Adult Psychiatry, Global Health, APH - Quality of Care, APH - Methodology, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Anesthesiology, Graduate School, and ACS - Heart failure & arrhythmias
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Male ,Latin Americans ,Nutrition and Disease ,Epidemiology ,[SDV]Life Sciences [q-bio] ,Medizin ,BLOOD-PRESSURE ,030204 cardiovascular system & hematology ,Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants ,Hypertension ,Prevalence ,Control ,Tretament ,GUIDELINES ,Global Health ,Worldwide trends ,0302 clinical medicine ,Hypertension prevalence ,Voeding en Ziekte ,Medicine and Health Sciences ,kohonnut verenpaine ,Medicine ,030212 general & internal medicine ,Prevention and Control ,11 Medical and Health Sciences ,ComputingMilieux_MISCELLANEOUS ,education.field_of_study ,food and beverages ,Public Health, Global Health, Social Medicine and Epidemiology ,General Medicine ,Noncommunicable diseases ,Period prevalence ,Middle Aged ,kansainvälinen vertailu ,3142 Public health care science, environmental and occupational health ,3. Good health ,MIDDLE-INCOME ,Pooled analysis ,SYSTEMATIC ANALYSIS ,INCOME COUNTRIES ,ADULTS ,PREVENTION ,MANAGEMENT ,ADHERENCE ,DIAGNOSIS ,Western europe ,[SDE]Environmental Sciences ,Hypertension/diagnosis ,NCD Risk Factor Collaboration (NCD-RisC) ,Female ,B990 Subjects Allied to Medicine not elsewhere classified ,Life Sciences & Biomedicine ,Adult ,health-care ,esiintyvyys ,Central asia ,Population ,Nursing ,3121 Internal medicine ,03 medical and health sciences ,Medicine, General & Internal ,Drug Therapy ,General & Internal Medicine ,Life Science ,Humans ,ddc:610 ,education ,Antihypertensive Agents ,VLAG ,Aged ,Science & Technology ,Antihypertensive Agents/therapeutic use ,business.industry ,Omvårdnad ,fungi ,General and internal medicine ,Estados de Saúde e de Doença ,Taking medication ,Treatment ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Blood pressure ,Faculdade de Ciências Sociais ,3121 General medicine, internal medicine and other clinical medicine ,lääkehoito ,1182 Biochemistry, cell and molecular biology ,business ,Demography - Abstract
Background: hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods: we used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings: the number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings., British Heart Foundation Centre of Research Excellence Grant; World Health Organization (WHO); Abdul Latif Jameel Institute for Disease and Emergency Analytics Fellowship
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- 2021
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24. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight
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Solfrizzi, V. Somi, M.H. Sonestedt, E. Song, Y. Sørensen, T.I.A. Sørgjerd, E.P. Jérome, C.S. Soto-Rojas, V.E. Soumaré, A. Sovic, S. Sparboe-Nilsen, B. Sparrenberger, K. Spinelli, A. Spiroski, I. Staessen, J.A. Stamm, H. Stathopoulou, M.G. Staub, K. Stavreski, B. Steene-Johannessen, J. Stehle, P. Stein, A.D. Stergiou, G.S. Stessman, J. Stevanovic, R. Stieber, J. Stöckl, D. Stocks, T. Stokwiszewski, J. Stoyanova, E. Stratton, G. Stronks, K. Strufaldi, M.W. Sturua, L. Suárez-Medina, S. Suka, M. Sun, C.-A. Sundström, J. Sung, Y.-T. Sunyer, J. Suriyawongpaisal, P. Swinburn, B.A. Sy, R.G. Syddall, H.E. Sylva, R.C. Szklo, M. Szponar, L. Tai, E.S. Tammesoo, M.-L. Tamosiunas, A. Tan, E.J. Tang, X. Tanrygulyyeva, M. Tanser, F. Tao, Y. Tarawneh, M.R. Tarp, J. Tarqui-Mamani, C.B. Braunerová, R.T. Taylor, A. Taylor, J. Tchibindat, F. Tebar, W.R. Tell, G.S. Tello, T. Tham, Y.C. Thankappan, K.R. Theobald, H. Theodoridis, X. Thijs, L. Thomas, N. Thuesen, B.H. Tichá, L. Timmermans, E.J. Tjonneland, A. Tolonen, H.K. Tolstrup, J.S. Topbas, M. Topór-Madry, R. Torheim, L.E. Tormo, M.J. Tornaritis, M.J. Torrent, M. Torres-Collado, L. Toselli, S. Touloumi, G. Traissac, P. Tran, T.T.-H. Trichopoulos, D. Trichopoulou, A. Trinh, D.T.H. Trivedi, A. Tshepo, L. Tsigga, M. Tsugane, S. Tuliakova, A.M. Tulloch-Reid, M.K. Tullu, F. Tuomainen, T.-P. Tuomilehto, J. Turley, M.L. Twig, G. Tynelius, P. Tzotzas, T. Tzourio, C. Ueda, P. Ugel, E. Ukoli, F.A.M. Ulmer, H. Unal, B. Usupova, Z. Uusitalo, H.M.T. Uysal, N. Vaitkeviciute, J. Valdivia, G. Vale, S. Valvi, D. van Dam, R.M. Van der Heyden, J. van der Schouw, Y.T. Van Herck, K. Van Minh, H. Van Schoor, N.M. van Valkengoed, I.G.M. Vanderschueren, D. Vanuzzo, D. Varbo, A. Varela-Moreiras, G. Varona-Pérez, P. Vasan, S.K. Vega, T. Veidebaum, T. Velasquez-Melendez, G. Velika, B. Veronesi, G. Verschuren, W.M.M. Victora, C.G. Viegi, G. Viet, L. Villalpando, S. Vineis, P. Vioque, J. Virtanen, J.K. Visser, M. Visvikis-Siest, S. Viswanathan, B. Vladulescu, M. Vlasoff, T. Vocanec, D. Vollenweider, P. Völzke, H. Voutilainen, A. Voutilainen, S. Vrijheid, M. Vrijkotte, T.G.M. Wade, A.N. Wagner, A. Waldhör, T. Walton, J. Wambiya, E.O.A. Bebakar, A.M.W. Mohamud, W.N.W. de Souza Wanderley Júnior, R. Wang, M.-D. Wang, N. Wang, Q. Wang, X. Wang, Y.X. Wang, Y.-W. Wannamethee, S.G. Wareham, N. Weber, A. Wedderkopp, N. Weerasekera, D. Weghuber, D. Wei, W. Weres, A. Werner, B. Whincup, P.H. Widhalm, K. Widyahening, I.S. Wiecek, A. Wilks, R.J. Willeit, J. Willeit, P. Williams, J. Wilsgaard, T. Wojtyniak, B. Wong-McClure, R.A. Wong, A. Wong, J.E. Wong, T.Y. Woo, J. Woodward, M. Wu, F.C. Wu, J. Wu, L.J. Wu, S. Xu, H. Xu, L. Yaacob, N.A. Yamborisut, U. Yan, W. Yang, L. Yang, X. Yang, Y. Yardim, N. Yaseri, M. Yasuharu, T. Ye, X. Yiallouros, P.K. Yoosefi, M. Yoshihara, A. You, Q.S. You, S.-L. Younger-Coleman, N.O. Yusof, S.M. Yusoff, A.F. Zaccagni, L. Zafiropulos, V. Zainuddin, A.A. Zakavi, S.R. Zamani, F. Zambon, S. Zampelas, A. Zamrazilová, H. Zapata, M.E. Zargar, A.H. Zaw, K.K. Zdrojewski, T. Zejglicova, K. Vrkic, T.Z. Zeng, Y. Zhang, L. Zhang, Z.-Y. Zhao, D. Zhao, M.-H. Zhao, W. Zhen, S. Zheng, W. Zheng, Y. Zholdin, B. Zhou, M. Zhu, D. Zins, M. Zitt, E. Zocalo, Y. Cisneros, J.Z. Zuziak, M. Ezzati, M. Filippi, S. NCD Risk Factor Collaboration (NCD-RisC)
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nutritional and metabolic diseases ,sense organs ,skin and connective tissue diseases - Abstract
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions. © Copyright.
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- 2021
25. Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies
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Jayasekara, H. MacInnis, R.J. Lujan-Barroso, L. Mayen-Chacon, A.-L. Cross, A.J. Wallner, B. Palli, D. Ricceri, F. Pala, V. Panico, S. Tumino, R. Kühn, T. Kaaks, R. Tsilidis, K. Sánchez, M.-J. Amiano, P. Ardanaz, E. Chirlaque López, M.D. Merino, S. Rothwell, J.A. Boutron-Ruault, M.-C. Severi, G. Sternby, H. Sonestedt, E. Bueno-de-Mesquita, B. Boeing, H. Travis, R. Sandanger, T.M. Trichopoulou, A. Karakatsani, A. Peppa, E. Tjønneland, A. Yang, Y. Hodge, A.M. Mitchell, H. Haydon, A. Room, R. Hopper, J.L. Weiderpass, E. Gunter, M.J. Riboli, E. Giles, G.G. Milne, R.L. Agudo, A. English, D.R. Ferrari, P.
- Abstract
Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity =.02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences. © 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
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- 2021
26. Plant foods, dietary fibre and risk of ischaemic heart disease in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Perez-Cornago, A. Crowe, F.L. Appleby, P.N. Bradbury, K.E. Wood, A.M. Jakobsen, M.U. Johnson, L. Sacerdote, C. Steur, M. Weiderpass, E. Würtz, A.M.L. Kühn, T. Katzke, V. Trichopoulou, A. Karakatsani, A. La Vecchia, C. Masala, G. Tumino, R. Panico, S. Sluijs, I. Skeie, G. Imaz, L. Petrova, D. Quirós, J.R. Yohar, S.M.C. Jakszyn, P. Melander, O. Sonestedt, E. Andersson, J. Wennberg, M. Aune, D. Riboli, E. Schulze, M.B. Di Angelantonio, E. Wareham, N.J. Danesh, J. Forouhi, N.G. Butterworth, A.S. Key, T.J.
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food and beverages - Abstract
Background: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD. Results: There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90-0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95-1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82-0.98, P-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85-0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91-0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95-1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk. Conclusions: In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear. © 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.
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- 2021
27. Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmö Diet and Cancer cohort
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Sonestedt, E, Ericson, U, Gullberg, B, Peñalvo, J L, Adlercreutz, H, and Wirfält, E
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- 2008
- Full Text
- View/download PDF
28. Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies.
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Jayasekara H., MacInnis R.J., Lujan-Barroso L., Mayen-Chacon A.-L., Cross A.J., Wallner B., Palli D., Ricceri F., Pala V., Panico S., Tumino R., Kuhn T., Kaaks R., Tsilidis K., Sanchez M.-J., Amiano P., Ardanaz E., Chirlaque Lopez M.D., Merino S., Rothwell J.A., Boutron-Ruault M.-C., Severi G., Sternby H., Sonestedt E., Bueno-de-Mesquita B., Boeing H., Travis R., Sandanger T.M., Trichopoulou A., Karakatsani A., Peppa E., Tjonneland A., Yang Y., Hodge A.M., Mitchell H., Haydon A., Room R., Hopper J.L., Weiderpass E., Gunter M.J., Riboli E., Giles G.G., Milne R.L., Agudo A., English D.R., Ferrari P., Jayasekara H., MacInnis R.J., Lujan-Barroso L., Mayen-Chacon A.-L., Cross A.J., Wallner B., Palli D., Ricceri F., Pala V., Panico S., Tumino R., Kuhn T., Kaaks R., Tsilidis K., Sanchez M.-J., Amiano P., Ardanaz E., Chirlaque Lopez M.D., Merino S., Rothwell J.A., Boutron-Ruault M.-C., Severi G., Sternby H., Sonestedt E., Bueno-de-Mesquita B., Boeing H., Travis R., Sandanger T.M., Trichopoulou A., Karakatsani A., Peppa E., Tjonneland A., Yang Y., Hodge A.M., Mitchell H., Haydon A., Room R., Hopper J.L., Weiderpass E., Gunter M.J., Riboli E., Giles G.G., Milne R.L., Agudo A., English D.R., and Ferrari P.
- Abstract
Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for >=60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity =.02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.Copyright © 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
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- 2021
29. Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies
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Jayasekara, H, MacInnis, RJ, Lujan-Barroso, L, Mayen-Chacon, A-L, Cross, AJ, Wallner, B, Palli, D, Ricceri, F, Pala, V, Panico, S, Tumino, R, Kuehn, T, Kaaks, R, Tsilidis, K, Sanchez, M-J, Amiano, P, Ardanaz, E, Chirlaque Lopez, MD, Merino, S, Rothwell, JA, Boutron-Ruault, M-C, Severi, G, Sternby, H, Sonestedt, E, Bueno-de-Mesquita, B, Boeing, H, Travis, R, Sandanger, TM, Trichopoulou, A, Karakatsani, A, Peppa, E, Tjonneland, A, Yang, Y, Hodge, AM, Mitchell, H, Haydon, A, Room, R, Hopper, JL, Weiderpass, E, Gunter, MJ, Riboli, E, Giles, GG, Milne, RL, Agudo, A, English, DR, Ferrari, P, Jayasekara, H, MacInnis, RJ, Lujan-Barroso, L, Mayen-Chacon, A-L, Cross, AJ, Wallner, B, Palli, D, Ricceri, F, Pala, V, Panico, S, Tumino, R, Kuehn, T, Kaaks, R, Tsilidis, K, Sanchez, M-J, Amiano, P, Ardanaz, E, Chirlaque Lopez, MD, Merino, S, Rothwell, JA, Boutron-Ruault, M-C, Severi, G, Sternby, H, Sonestedt, E, Bueno-de-Mesquita, B, Boeing, H, Travis, R, Sandanger, TM, Trichopoulou, A, Karakatsani, A, Peppa, E, Tjonneland, A, Yang, Y, Hodge, AM, Mitchell, H, Haydon, A, Room, R, Hopper, JL, Weiderpass, E, Gunter, MJ, Riboli, E, Giles, GG, Milne, RL, Agudo, A, English, DR, and Ferrari, P
- Abstract
Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.
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- 2021
30. Food patterns, inflammation markers and incidence of cardiovascular disease: the Malmö Diet and Cancer study
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Hlebowicz, J., Persson, M., Gullberg, B., Sonestedt, E., Wallström, P., Drake, I., Nilsson, J., Hedblad, B., and Wirfält, E.
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- 2011
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31. Association between fat intake, physical activity and mortality depending on genetic variation in FTO
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Sonestedt, E, Gullberg, B, Ericson, U, Wirfält, E, Hedblad, B, and Orho-Melander, M
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- 2011
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32. DIETARY FIBER INTAKE MODIFIES THE EFFECT OF TCF7L2 RS7903146 ON THE RISK OF INCIDENT TYPE 2 DIABETES IN THE MALMÖ DIET AND CANCER COHORT
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Hindy, G., Sonestedt, E., Ericson, U., Wirfält, E., and Orho-Melander, M.
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- 2011
33. Association between added sugar intake and intima media thickness as a marker for atherosclerosis: A cross sectional study in the malmö diet and cancer study
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González-Padilla, E., primary and Sonestedt, E., additional
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- 2020
- Full Text
- View/download PDF
34. Total dietary carbohydrate, sugar, starch and fibre intakes in the European Prospective Investigation into Cancer and Nutrition
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Cust, A E, Skilton, M R, van Bakel, MME, Halkjær, J, Olsen, A, Agnoli, C, Psaltopoulou, T, Buurma, E, Sonestedt, E, Chirlaque, M D, Rinaldi, S, Tjønneland, A, Jensen, M K, Clavel-Chapelon, F, Boutron-Ruault, M C, Kaaks, R, Nöthlings, U, Chloptsios, Y, Zylis, D, Mattiello, A, Caini, S, Ocké, M C, van der Schouw, Y T, Skeie, G, Parr, C L, Molina-Montes, E, Manjer, J, Johansson, I, McTaggart, A, Key, T J, Bingham, S, Riboli, E, and Slimani, N
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- 2009
35. Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries
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Deschasaux, M. Huybrechts, I. Julia, C. Hercberg, S. Egnell, M. Srour, B. Kesse-Guyot, E. Latino-Martel, P. Biessy, C. Casagrande, C. Murphy, N. Jenab, M. Ward, H.A. Weiderpass, E. Overvad, K. Tjønneland, A. Rostgaard-Hansen, A.L. Boutron-Ruault, M.-C. Mancini, F.R. Mahamat-Saleh, Y. Kühn, T. Katzke, V. Bergmann, M.M. Schulze, M.B. Trichopoulou, A. Karakatsani, A. Peppa, E. Masala, G. Agnoli, C. De Magistris, M.S. Tumino, R. Sacerdote, C. Boer, J.M.A. Monique Verschuren, W.M. Van Der Schouw, Y.T. Skeie, G. Braaten, T. Luisa Redondo, M. Agudo, A. Petrova, D. Colorado-Yohar, S.M. Barricarte, A. Amiano, P. Sonestedt, E. Ericson, U. Otten, J. Sundström, B. Wareham, N.J. Forouhi, N.G. Vineis, P. Tsilidis, K.K. Knuppel, A. Papier, K. Ferrari, P. Riboli, E. Gunter, M.J. Touvier, M.
- Abstract
Objective To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide consumers towards healthier food choices, is associated with mortality. Design Population based cohort study. Setting European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from 23 centres in 10 European countries. Participants 521 324 adults; at recruitment, country specific and validated dietary questionnaires were used to assess their usual dietary intakes. A FSAm-NPS score was calculated for each food item per 100 g content of energy, sugars, saturated fatty acids, sodium, fibre, and protein, and of fruit, vegetables, legumes, and nuts. The FSAm-NPS dietary index was calculated for each participant as an energy weighted mean of the FSAm-NPS score of all foods consumed. The higher the score the lower the overall nutritional quality of the diet. Main outcome measure Associations between the FSAm-NPS dietary index score and mortality, assessed using multivariable adjusted Cox proportional hazards regression models. Results After exclusions, 501 594 adults (median follow-up 17.2 years, 8 162 730 person years) were included in the analyses. Those with a higher FSAm-NPS dietary index score (highest versus lowest fifth) showed an increased risk of all cause mortality (n=53 112 events from non-external causes; hazard ratio 1.07, 95% confidence interval 1.03 to 1.10, P
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- 2020
36. A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort
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Christakoudi, S. Tsilidis, K.K. Muller, D.C. Freisling, H. Weiderpass, E. Overvad, K. Söderberg, S. Häggström, C. Pischon, T. Dahm, C.C. Zhang, J. Tjønneland, A. Halkjær, J. MacDonald, C. Boutron-Ruault, M.-C. Mancini, F.R. Kühn, T. Kaaks, R. Schulze, M.B. Trichopoulou, A. Karakatsani, A. Peppa, E. Masala, G. Pala, V. Panico, S. Tumino, R. Sacerdote, C. Quirós, J.R. Agudo, A. Sánchez, M.-J. Cirera, L. Barricarte-Gurrea, A. Amiano, P. Memarian, E. Sonestedt, E. Bueno-de-Mesquita, B. May, A.M. Khaw, K.-T. Wareham, N.J. Tong, T.Y.N. Huybrechts, I. Noh, H. Aglago, E.K. Ellingjord-Dale, M. Ward, H.A. Aune, D. Riboli, E.
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nutritional and metabolic diseases - Abstract
Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI < 18.5 kg/m2) or obese (BMI ≥ 30 kg/m2) categories, while the highest quartile of ABSI separated 18–39% of the individuals within each BMI category, which had 22–55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring. © 2020, The Author(s).
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- 2020
37. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition
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Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., Duell, E.J., IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2
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prospective cohort study ,pancreatic cancer ,nuts ,seeds ,diet ,EPIC ,intake - Abstract
Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.
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- 2020
38. Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults
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Cordova, R. Knaze, V. Viallon, V. Rust, P. Schalkwijk, C.G. Weiderpass, E. Wagner, K.-H. Mayen-Chacon, A.-L. Aglago, E.K. Dahm, C.C. Overvad, K. Tjønneland, A. Halkjær, J. Mancini, F.R. Boutron-Ruault, M.-C. Fagherazzi, G. Katzke, V. Kühn, T. Schulze, M.B. Boeing, H. Trichopoulou, A. Karakatsani, A. Thriskos, P. Masala, G. Krogh, V. Panico, S. Tumino, R. Ricceri, F. Spijkerman, A. Boer, J. Skeie, G. Rylander, C. Borch, K.B. Quirós, J.R. Agudo, A. Redondo-Sánchez, D. Amiano, P. Gómez-Gómez, J.-H. Barricarte, A. Ramne, S. Sonestedt, E. Johansson, I. Esberg, A. Tong, T. Aune, D. Tsilidis, K.K. Gunter, M.J. Jenab, M. Freisling, H.
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Purpose: Advanced glycation end products (AGEs) can be formed in foods by the reaction of reducing sugars with proteins, and have been shown to induce insulin resistance and obesity in experimental studies. We examined the association between dietary AGEs intake and changes in body weight in adults over an average of 5 years of follow-up. Methods: A total of 255,170 participants aged 25–70 years were recruited in ten European countries (1992–2000) in the PANACEA study (Physical Activity, Nutrition, Alcohol, Cessation of smoking, Eating out of home in relation to Anthropometry), a sub-cohort of the EPIC (European Prospective Investigation into Cancer and Nutrition). Body weight was measured at recruitment and self-reported between 2 and 11 years later depending on the study center. A reference database for AGEs was used containing UPLC–MS/MS-measured Nε-(carboxymethyl)-lysine (CML), Nε-(1-carboxyethyl)-lysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) in 200 common European foods. This reference database was matched to foods and decomposed recipes obtained from country-specific validated dietary questionnaires in EPIC and intake levels of CEL, CML, and MG-H1 were estimated. Associations between dietary AGEs intake and body weight change were estimated separately for each of the three AGEs using multilevel mixed linear regression models with center as random effect and dietary AGEs intake and relevant confounders as fixed effects. Results: A one-SD increment in CEL intake was associated with 0.111 kg (95% CI 0.087–0.135) additional weight gain over 5 years. The corresponding additional weight gain for CML and MG-H1 was 0.065 kg (0.041–0.089) and 0.034 kg (0.012, 0.057), respectively. The top six food groups contributing to AGEs intake, with varying proportions across the AGEs, were cereals/cereal products, meat/processed meat, cakes/biscuits, dairy, sugar and confectionary, and fish/shellfish. Conclusion: In this study of European adults, higher intakes of AGEs were associated with marginally greater weight gain over an average of 5 years of follow-up. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
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- 2020
39. The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: A prospective study of 418 329 participants in the EPIC cohort across nine European countries
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Tong, T.Y.N. Appleby, P.N. Key, T.J. Dahm, C.C. Overvad, K. Olsen, A. Tjønneland, A. Katzke, V. Kühn, T. Boeing, H. Karakatsani, A. Peppa, E. Trichopoulou, A. Weiderpass, E. Masala, G. Grioni, S. Panico, S. Tumino, R. Boer, J.M.A. Verschuren, W.M.M. Quirós, J.R. Agudo, A. Rodríguez-Barranco, M. Imaz, L. Chirlaque, M.-D. Moreno-Iribas, C. Engström, G. Sonestedt, E. Lind, M. Otten, J. Khaw, K.-T. Aune, D. Riboli, E. Wareham, N.J. Imamura, F. Forouhi, N.G. Di Angelantonio, E. Wood, A.M. Butterworth, A.S. Perez-Cornago, A.
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Aim: To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. Methods and results: We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over the past year, calibrated using 24-h recalls. Multivariable-adjusted Cox regressions were used to estimate hazard ratios (HRs) for ischaemic and haemorrhagic stroke associated with consumption of red and processed meat, poultry, fish, dairy foods, eggs, cereals, fruit and vegetables, legumes, nuts and seeds, and dietary fibre. For ischaemic stroke (4281 cases), lower risks were observed with higher consumption of fruit and vegetables combined (HR; 95% CI per 200 g/day higher intake, 0.87; 0.82-0.93, P-trend < 0.001), dietary fibre (per 10 g/day, 0.77; 0.69-0.86, P-trend < 0.001), milk (per 200 g/day, 0.95; 0.91-0.99, P-trend = 0.02), yogurt (per 100 g/day, 0.91; 0.85-0.97, P-trend = 0.004), and cheese (per 30 g/day, 0.88; 0.81-0.97, P-trend = 0.008), while higher risk was observed with higher red meat consumption which attenuated when adjusted for the other statistically significant foods (per 50 g/day, 1.07; 0.96-1.20, P-trend = 0.20). For haemorrhagic stroke (1430 cases), higher risk was associated with higher egg consumption (per 20 g/day, 1.25; 1.09-1.43, P-trend = 0.002). Conclusion: Risk of ischaemic stroke was inversely associated with consumption of fruit and vegetables, dietary fibre, and dairy foods, while risk of haemorrhagic stroke was positively associated with egg consumption. The apparent differences in the associations highlight the importance of examining ischaemic and haemorrhagic stroke subtypes separately. © 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.
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- 2020
40. Glycemic index, glycemic load, and risk of coronary heart disease: A pan-European cohort study
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Sieri, S. Agnoli, C. Grioni, S. Weiderpass, E. Mattiello, A. Sluijs, I. Sanchez, M.J. Jakobsen, M.U. Sweeting, M. van der Schouw, Y.T. Nilsson, L.M. Wennberg, P. Katzke, V.A. Kühn, T. Overvad, K. Tong, T.Y.N. Conchi, M.-I. Quirós, J.R. García-Torrecillas, J.M. Mokoroa, O. Gómez, J.-H. Tjønneland, A. Sonestedt, E. Trichopoulou, A. Karakatsani, A. Valanou, E. Boer, J.M.A. Monique Verschuren, W.M. Boutron-Ruault, M.-C. Fagherazzi, G. Madika, A.-L. Bergmann, M.M. Schulze, M.B. Ferrari, P. Freisling, H. Lennon, H. Sacerdote, C. Masala, G. Tumino, R. Riboli, E. Wareham, N.J. Danesh, J. Forouhi, N.G. Butterworth, A.S. Krogh, V.
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Background: High carbohydrate intake raises blood triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (CHD). Epidemiological studies indicate that high dietary glycemic index (GI) and glycemic load (GL) are associated with increased CHD risk. Objectives: The aim of this study was to determine whether dietary GI, GL, and available carbohydrates are associated with CHD risk in both sexes. Methods: This large prospective study-the European Prospective Investigation into Cancer and Nutrition-consisted of 338,325 participants who completed a dietary questionnaire. HRs with 95% CIs for a CHD event, in relation to intake of GI, GL, and carbohydrates, were estimated using covariate-adjusted Cox proportional hazard models. Results: After 12.8 y (median), 6378 participants had experienced a CHD event. High GL was associated with greater CHD risk [HR 1.16 (95% CI: 1.02, 1.31) highest vs. lowest quintile, p-trend 0.035; HR 1.18 (95% CI: 1.07, 1.29) per 50 g/day of GL intake]. The association between GL and CHD risk was evident in subjects with BMI (in kg/m2) =25 [HR: 1.22 (95% CI: 1.11, 1.35) per 50 g/d] but not in those with BMI
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- 2020
41. National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio:a pooled analysis of 458 population-based studies in Asian and Western countries
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Taddei, C. (Cristina), Jackson, R. (Rod), Zhou, B. (Bin), Bixby, H. (Honor), Danaei, G. (Goodarz), Di Cesare, M. (Mariachiara), Kuulasmaa, K. (Kari), Hajifathalian, K. (Kaveh), Bentham, J. (James), Bennett, J. E. (James E.), Aekplakorn, W. (Wichai), Cifkova, R. (Renata), Dallongeville, J. (Jean), DeBacquer, D. (Dirk), Giampaoli, S. (Simona), Gudnason, V. (Vilmundur), Khang, Y.-H. (Young-Ho), Laatikainen, T. (Tiina), Mann, J. I. (Jim, I), Marques-Vidal, P. (Pedro), Mensah, G. A. (George A.), Mueller-Nurasyid, M. (Martina), Ninomiya, T. (Toshiharu), Petkeviciene, J. (Janina), Rodriguez-Artalejo, F. (Fernando), Servais, J. (Jennifer), Soderberg, S. (Stefan), Stavreski, B. (Bill), Wilsgaard, T. (Tom), Zdrojewski, T. (Tomasz), Zhao, D. (Dong), Stevens, G. A. (Gretchen A.), Savin, S. (Stefan), Cowan, M. J. (Melanie J.), Riley, L. M. (Leanne M.), Ezzati, M. (Majid), Adams, R. J. (Robert J.), Ahrens, W. (Wolfgang), Amouyel, P. (Philippe), Amuzu, A. (Antoinette), Anderssen, S. A. (Sigmund A.), Ariansen, I. (Inger), Arveiler, D. (Dominique), Aspelund, T. (Thor), Auvinen, J. (Juha), Avdicova, M. (Maria), Banach, M. (Maciej), Bandosz, P. (Piotr), Banegas, J. R. (Jose R.), Barbagallo, C. M. (Carlo M.), Bata, I. (Iqbal), Baur, L. A. (Louise A.), Beaglehole, R. (Robert), Bernotiene, G. (Gailute), Bi, Y. (Yufang), Bienek, A. (Asako), Bjorkelund, C. (Cecilia), Bo, S. (Simona), Boehm, B. O. (Bernhard O.), Bonaccio, M. (Marialaura), Bongard, V. (Vanina), Borchini, R. (Rossana), Borghs, H. (Herman), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Bruno, G. (Graziella), Busch, M. A. (Markus A.), Cabrera de Leon, A. (Antonio), Capuano, V. (Vincenzo), Casanueva, F. F. (Felipe F.), Casas, J.-P. (Juan-Pablo), Caserta, C. A. (Carmelo A.), Censi, L. (Laura), Chen, F. (Fangfang), Chen, S. (Shuohua), Chirlaque, M.-D. (Maria-Dolores), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Claessens, F. (Frank), Clarke, J. (Janine), Clays, E. (Els), Cooper, C. (Cyrus), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A. B. (Ana B.), Cui, L. (Liufu), D'Arrigo, G. (Graziella), Dauchet, L. (Luc), De Backer, G. (Guy), De Bacquer, D. (Dirk), de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), De Smedt, D. (Delphine), Dennison, E. (Elaine), Deschamps, V. (Valerie), Di Castelnuovo, A. (Augusto), Dobson, A. J. (Annette J.), Donfrancesco, C. (Chiara), Doering, A. (Angela), Drygas, W. (Wojciech), Du, Y. (Yong), Dziankowska-Zaborszczyk, E. (Elzbieta), Eggertsen, R. (Robert), Ekelund, U. (Ulf), Elosua, R. (Roberto), Eriksson, J. G. (Johan G.), Evans, A. (Alun), Faeh, D. (David), Felix-Redondo, F. J. (Francisco J.), Fernandez-Berges, D. (Daniel), Ferrari, M. (Marika), Ferrieres, J. (Jean), Finn, J. D. (Joseph D.), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Frontera, G. (Guillermo), Fujita, Y. (Yuki), Gaciong, Z. (Zbigniew), Galvano, F. (Fabio), Gao, J. (Jingli), Garcia-de-la-Hera, M. (Manoli), Garnett, S. P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gates, L. (Louise), Gianfagna, F. (Francesco), Gill, T. K. (Tiffany K.), Giovannelli, J. (Jonathan), Giwercman, A. (Aleksander), Goltzman, D. (David), Gonzalez Gross, M. (Marcela), Gottrand, F. (Frederic), Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dusan), Gregor, R. D. (Ronald D.), Grodzicki, T. (Tomasz), Grosso, G. (Giuseppe), Gruden, G. (Grabriella), Gu, D. (Dongfeng), Guallar-Castillon, P. (Pilar), Gudmundsson, E. F. (Elias F.), Guessous, I. (Idris), Gunnlaugsdottir, J. (Johanna), Gutzwiller, F. (Felix), Hardy, R. (Rebecca), Hata, J. (Jun), Haugsgjerd, T. (Teresa), Hayes, A. J. (Alison J.), He, J. (Jiang), He, Y. (Yuna), Herrala, S. (Sauli), Hihtaniemi, I. T. (Ilpo Tapani), Hobbs, M. (Michael), Hopman, W. M. (Wilma M.), Maria Huerta, J. (Josi), Huybrechts, I. (Inge), Iacoviello, L. (Licia), Iannone, A. G. (Anna G.), Ikeda, N. (Nayu), Iwasaki, M. (Masanori), Jamrozik, K. (Konrad), Janszky, I. (Imre), Jarvelin, M.-R. (Marjo-Riitta), Jasienska, G. (Grazyna), Jennings, G. (Garry), Jeong, S.-L. (Seung-Lyeal), Jiang, C. Q. (Chao Qiang), Joffres, M. (Michel), Jokelainen, J. J. (Jari J.), Jonas, J. B. (Jost B.), Jozwiak, J. (Jacek), Kajantie, E. O. (Eero O.), Kauhanen, J. (Jussi), Keil, U. (Ulrich), Keinanen-Kiukaanniemi, S. (Sirkka), Kersting, M. (Mathilde), Kiechl-Kohlendorfer, U. (Ursula), Kiechl, S. (Stefan), Kim, J. (Jeongseon), Kim, Y.-Y. (Yeon-Yong), Klumbiene, J. (Jurate), Knoflach, M. (Michael), Ko, S. (Stephanie), Kolle, E. (Elin), Korpelainen, R. (Raija), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Kratzer, W. (Wolfgang), Kriemler, S. (Susi), Krokstad, S. (Steinar), Kujala, U. M. (Urho M.), Kurjata, P. (Pawel), Lam, T. H. (Tai Hing), Lanska, V. (Vera), Lappas, G. (Georg), Laugsand, L. E. (Lars E.), Lee, J. (Jeonghee), Lehtimaki, T. (Terho), Li, Y. (Yanping), Lilly, C. L. (Christa L.), Lin, X. (Xu), Lind, L. (Lars), Lissner, L. (Lauren), Liu, J. (Jing), Lopez-Garcia, E. (Esther), Lorbeer, R. (Roberto), Eugenio Lozano, J. (Jose), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lundqvist, R. (Robert), Lytsy, P. (Per), Ma, G. (Guansheng), Machi, S. (Suka), Maggi, S. (Stefania), Magliano, D. J. (Dianna J.), Manzato, E. (Enzo), Mathiesen, E. B. (Ellisiv B.), McLachlan, S. (Stela), McLean, R. M. (Rachael M.), McLean, S. B. (Scott B.), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Metcalf, P. (Patricia), Mi, J. (Jie), Miller, J. C. (Jody C.), Moreno, L. A. (Luis A.), Morin, S. N. (Suzanne N.), Mossakowska, M. (Malgorzata), Muiesan, M. L. (Maria L.), Mursu, J. (Jaakko), Nakamura, H. (Harunobu), Namesna, J. (Jana), Nauck, M. (Matthias), Maria Navarrete-Munoz, E. (Eva), Neal, W. A. (William A.), Nenko, I. (Ilona), Niiranen, T. J. (Teemu J.), Ning, G. (Guang), Noale, M. (Marianna), Norie, S. (Sawada), Noto, D. (Davide), O'Neill, T. (Terence), O'Reilly, D. (Dermot), Oh, K. (Kyungwon), Olafsson, O. (Orn), Paccaud, F. M. (Fred Michel), Pajak, A. (Andrzej), Palmieri, L. (Luigi), Panza, F. (Francesco), Parnell, W. R. (Winsome R.), Peltonen, M. (Markku), Peters, A. (Annette), Petersmann, A. (Astrid), Pigeot, I. (Iris), Pilotto, L. (Lorenza), Piwonska, A. (Aleksandra), Plans-Rubio, P. (Pedro), Porta, M. (Miquel), Price, J. F. (Jacqueline F.), Puder, J. J. (Jardena J.), Puhakka, S. E. (Soile E.), Radisauskas, R. (Ricardas), Raitakari, O. (Olli), Ramos, R. (Rafel), Redon, J. (Josep), Rigo, F. (Fernando), del Cristo Rodriguez-Perez, M. (Maria), Romaguera, D. (Dora), Ronkainen, K. (Kimmo), Rosengren, A. (Annika), Roy, J. G. (Joel G. R.), Ruidavets, J.-B. (Jean-Bernard), Rutkowski, M. (Marcin), Salanave, B. (Benoit), Salmeron, D. (Diego), Salomaa, V. (Veikko), Salonen, J. T. (Jukka T.), Salvetti, M. (Massimo), Sans, S. (Susana), Saramies, J. L. (Jouko L.), Saum, K.-U. (Kai-Uwe), Scheidt-Nave, C. (Christa), Schienkiewitz, A. (Anja), Schipf, S. (Sabine), Schmidt, C. O. (Carsten O.), Schoettker, B. (Ben), Sebert, S. (Sylvain), Sen, A. (Abhijit), Shaw, J. E. (Jonathan E.), Shibuya, K. (Kenji), Shin, D. W. (Dong Wook), Shiri, R. (Rahman), Simons, J. (Judith), Simons, L. A. (Leon A.), Sjostrom, M. (Michael), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Solfrizzi, V. (Vincenzo), Sonestedt, E. (Emily), Soumare, A. (Aicha), Staessen, J. A. (Jan A.), Stathopoulou, M. G. (Maria G.), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stieber, J. (Jutta), Stoeckl, D. (Doris), Stokwiszewski, J. (Jakub), Sundstrom, J. (Johan), Suriyawongpaisal, P. (Paibul), Tamosiunas, A. (Abdonas), Tan, E. J. (Eng Joo), Taylor, A. (Anne), Tell, G. (Grethe), Thijs, L. (Lutgarde), Tolonen, H. K. (Hanna K.), Topor-Madry, R. (Roman), Jose Tormo, M. (Maria), Torrent, M. (Maties), Tsugane, S. (Shoichiro), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tzourio, C. (Christophe), Uusitalo, H. M. (Hannu M. T.), Van Herck, K. (Koen), Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Vatten, L. (Lars), Vega, T. (Tomas), Veronesi, G. (Giovanni), Vioque, J. (Jesus), Virtanen, J. K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Vollenweider, P. (Peter), Voutilainen, S. (Sari), Vrijheid, M. (Martine), Wagner, A. (Aline), Wagner, A. (Anne), Wang, M.-D. (Ming-Dong), Wang, Q. (Qian), Wang, Y. X. (Ya Xing), Wannamethee, S. G. (S. Goya), Wei, W. (Wenbin), Whincup, P. H. (Peter H.), Wiecek, A. (Andrzej), Willeit, J. (Johann), Willeit, P. (Peter), Wojtyniak, B. (Bogdan), Wong, A. (Andrew), Woodward, M. (Mark), Wu, F. C. (Frederick C.), Wu, S. (Shouling), Xu, H. (Haiquan), Xu, L. (Liang), Yan, W. (Weili), Yang, X. (Xiaoguang), Ye, X. (Xingwang), Yoshihara, A. (Akihiro), Zambon, S. (Sabina), and Zhao, W. (Wenhua)
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blood lipids ,HDL cholesterol ,LDL cholesterol ,total cholesterol ,nutritional and metabolic diseases ,lipids (amino acids, peptides, and proteins) ,multi-country study - Abstract
Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.
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- 2020
42. The association between the intake of specific dietary components and lifestyle factors and microscopic colitis
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Larsson, J K, Sonestedt, E, Ohlsson, B, Manjer, J, and Sjöberg, K
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Lifestyles -- Health aspects ,Colitis -- Physiological aspects ,Food/cooking/nutrition ,Health - Abstract
Background/Objectives: The incidence of microscopic colitis (MC) has increased over the previous decades. In addition to smoking and drugs, currently unidentified environmental factors may have a role. The aim of this study was to determine whether specific dietary or other lifestyle factors were associated with the development of MC. Subject/Methods: The population-based cohort Malmö Diet and Cancer Study of 28 095 individuals was examined. Information about dietary habits was collected by a modified diet history method. Data on anthropometry were measured, and socio-economic and lifestyle factors were collected by questionnaires. Cases of MC were identified in medical registers. Associations were estimated using Cox regression analysis. Results: During a 22-year period, 135 patients were diagnosed with MC. Intakes of protein, carbohydrates, sucrose, saturated fat, monounsaturated fat, polyunsaturated fat, omega-3 or omega-6 fatty acids, fibre and zinc were not associated with MC. We could verify the previously reported association between MC and smoking (hazard ratio (HR): 2.29; 95% confidence interval (CI): 1.66-3.84) and the female gender (HR: 3.57; 95% CI: 2.22-5.74). High alcohol consumption was associated with an increased risk for MC (HR: 1.89 for the highest quartile; 95% CI: 0.82-4.33, P for trend=0.032). In a post hoc analysis, alcohol intake including all patients independently of consumption seemed to reduce the smoking-related risk. Conclusions: Despite a large cohort and a long follow-up period, we could not detect any dietary risk factors for MC. The aetiological mechanisms behind the positive impact of smoking and alcohol on MC risk should be investigated. European Journal of Clinical Nutrition (2016) 70, 1309-1317; doi: 10.1038/ejcn.2016.130; published online 27 July 2016, Author(s): J K Larsson [1]; E Sonestedt [2]; B Ohlsson [3]; J Manjer [4]; K Sjöberg [1] Introduction Microscopic colitis (MC) is an inflammatory disorder in the colonic mucosa that [...]
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- 2016
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43. Gut microbiota composition in relation to intake of added sugar, sugar-sweetened beverages and artificially sweetened beverages in the Malmö Offspring Study
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Ramne, S., Brunkwall, L., Ericson, U., Gray, N., Kuhnle, G.G.C., Nilsson, P.M., Orho-Melander, M., Sonestedt, E., Ramne, S., Brunkwall, L., Ericson, U., Gray, N., Kuhnle, G.G.C., Nilsson, P.M., Orho-Melander, M., and Sonestedt, E.
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Purpose It has been suggested that a high intake of sugar or sweeteners may result in an unfavorable microbiota composition; however, evidence is lacking. Hence, in this exploratory epidemiological study, we aim to examine if intake of added sugar, sugar-sweetened beverages (SSBs) or artificially sweetened beverages (ASBs) associate with the gut microbiota composition. Methods Participants (18–70 years) in the Malmö Offspring Study have provided blood, urine, and fecal samples and completed both web-based 4 day food records and short food frequency questionnaires. The gut microbiota was assessed by 16S rRNA sequencing, processed in QIIME and matched to Greengenes (v.13.8), giving 64 included genera after filtering. Intake of added sugar (n = 1371) (also supported by the overnight urinary sugar biomarker in a subgroup n = 577), SSBs (n = 1086) and ASBs (n = 1085) were examined as exposures in negative binomial regressions. Results Various genera nominally associated with intake of added sugar, SSBs, and ASBs. Only the negative association between SSB intake and Lachnobacterium remained significant after multiple testing correction. A positive association between SSB intake and the Firmicutes:Bacteroidetes ratio was also observed. Conclusion In this wide population, the cross-sectional associations between added sugar and sweet beverage intake and the gut microbiota are modest, but the results suggest that SSB intake is associated negatively with the genus Lachnobacterium and positively with the Firmicutes:Bacteroidetes ratio. Larger studies, preferably using metagenomic sequencing, are needed to further evaluate if a link exists between intake of sugars and sweeteners and the human gut microbiota.
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- 2020
44. Repositioning of the global epicentre of non-optimal cholesterol
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Taddei, C. (Cristina), Zhou, B. (Bin), Bixby, H. (Honor), Carrillo-Larco, R.M. (Rodrigo M.), Danaei, G. (Goodarz), Jackson, R.T. (Rod T.), Farzadfar, F. (Farshad), Sophiea, M.K. (Marisa K.), Di Cesare, M. (Mariachiara), Iurilli, M.L.C. (Maria Laura Caminia), Martinez, A.R. (Andrea Rodriguez), Asghari, G. (Golaleh), Dhana, K. (Klodian), Gulayin, P. (Pablo), Kakarmath, S. (Sujay), Santero, M. (Marilina), Voortman, R.G. (Trudy), Riley, L.M. (Leanne M.), Cowan, M.J. (Melanie J.), Savin, S. (Stefan), Bennett, J.E. (James E.), Stevens, G.A. (Gretchen A.), Paciorek, C.J. (Christopher J.), Aekplakorn, W. (Wichai), Cifkova, R. (Renata), Giampaoli, S. (Simona), Kengne, A.P. (Andre Pascal), Khang, Y.-H. (Young-Ho), Kuulasmaa, K. (Kari), Laxmaiah, A. (Avula), Margozzini, P. (Paula), Mathur, P. (Prashant), Nordestgaard, B.G. (Børge), Zhao, D. (Dong), Aadahl, M. (Mette), Abarca-Gómez, L. (Leandra), Rahim, H.A. (Hanan Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R.J. (Robert J.), Agdeppa, I.A. (Imelda A.), Aghazadeh-Attari, J. (Javad), Aguilar-Salinas, C.A. (Carlos A.), Agyemang, C.O. (Charles), Ahluwalia, T.S. (Tarunveer Singh), Ahmad, N.A. (Noor Ani), Ahmadi, A. (Ali), Ahmadi, N. (Naser), Ahmed, S.H. (Soheir H.), Ahrens, W. (W.), Ajlouni, K. (Kamel), Alarouj, M. (Monira), AlBuhairan, F. (Fadia), AlDhukair, S. (Shahla), Ali, M.M. (Mohamed M.), Alkandari, A. (Abdullah), Alkerwi, A. (Ala’a), Aly, E. (Eman), Amarapurkar, D.N. (Deepak N.), Amouyel, P. (Philippe), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Ansari-Moghaddam, A. (Alireza), Aounallah-Skhiri, H. (Hajer), Araújo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arku, R.E. (Raphael E.), Arlappa, N. (Nimmathota), Aryal, K.K. (Krishna K.), Aspelund, T. (Thor), Assunção, M.C.F. (Maria Cecília F.), Auvinen, J. (Juha), Avdicová, M. (Mária), Azevedo, A. (Ana), Azizi, J. (Joshan), Azmin, M. (Mehrdad), Balakrishna, N. (Nagalla), Bamoshmoosh, M. (Mohamed), Banach, M. (Maciej), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batyrbek, A. (Assembekov), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Belavendra, A. (Antonisamy), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benn, M. (Marianne), Berkinbayev, S. (Salim), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhargava, S.K. (Santosh K.), Bi, Y. (Yufang), Bienek, A. (Asako), Bikbov, M. (Mukharram), Bista, B. (Bihungum), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Bloch, K.V. (Katia V.), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B.O. (Bernhard O.), Boggia, J.G. (Jose G.), Boissonnet, C.P. (Carlos P.), Bonaccio, M. (Marialaura), Bongard, V. (Vanina), Borchini, R. (Rossana), Borghs, H. (Herman), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Bruno, G. (Graziella), Bugge, A. (Anna), Busch, M.A. (Markus A.), de León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capanzana, M.V. (Mario V.), Capuano, E. (Eduardo), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, J. (Joana), Casanueva, F.F., Censi, L. (Laura), Chadjigeorgiou, C.A. (Charalambos A.), Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nish), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Cheraghian, B. (Bahman), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Chirlaque, M.D. (M.), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Claessens, F. (Frank), Clarke, J. (Janine), Clays, E. (Els), Concin, H. (Hans), Confortin, S.C. (Susana C.), Cooper, C. (Charles), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A.B. (Ana B.), Csilla, S. (Semánová), Cui, L. (Liufu), Cureau, F.V. (Felipe V.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T.M. (Thomas M.), Dauchet, L. (Luc), Davletov, K. (Kairat), Backer, G. (Guy) de, Bacquer, D. (Dirk) de, de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), de Oliveira, P.D. (Paula Duarte), De Ridder, D. (David), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Dennison, E.M. (Elaine), Deschamps, V. (Valérie), Dhimal, M. (Meghnath), Di Castelnuovo, A.F. (Augusto F.), Dika, Z. (Zivka), Djalalinia, S. (Shirin), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Dorobantu, M. (Maria), Dragano, N. (Nico), Drygas, W. (Wojciech), Du, Y. (Yong), Duante, C.A. (Charmaine A.), Duda, R.B. (Rosemary B.), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eddie, R. (Ricky), Eftekhar, E. (Ebrahim), Eggertsen, R. (Robert), Eghtesad, S. (Sareh), Eiben, G. (Gabriele), Ekelund, U. (Ulf), El Ati, J. (Jalila), Eldemire-Shearer, D. (Denise), Eliasen, M. (Marie), Elosua, R. (Roberto), Erasmus, R.T. (Rajiv T.), Erbel, R. (Raimund), Erem, C. (Cihangir), Eriksen, L. (Louise), Hagen, K. (Knut), Escobedo-de la Peña, J. (Jorge), Eslami, S. (Saeid), Esmaeili, A. (Ali), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Faramarzi, E. (Elnaz), Farjam, M. (Mojtaba), Fattahi, M.R. (Mohammad Reza), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), do Carmo Franco, M. (Maria), Franco, O.H. (Oscar H.), Frontera, G. (Guillermo), Fujita, Y. (Yuki), Fumihiko, M. (Matsuda), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Galvano, F. (Fabio), Gao, J. (Jingli), Garcia-de-la-Hera, M. (Manoli), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gazzinelli, A. (Andrea), Geleijnse, J.M. (Marianne), Ghanbari, A. (Ali), Ghasemi, E. (Erfan), Gheorghe-Fronea, O.-F. (Oana-Florentina), Ghimire, A. (Anup), Gianfagna, F. (Francesco), Gill, T.K. (Tiffany K.), Giovannelli, J. (Jonathan), Gironella, G. (Glen), Giwercman, A. (Aleksander), Goltzman, D. (David), Gonçalves, H. (Helen), Gonzalez-Chica, D.A. (David A.), Gonzalez-Gross, M. (Marcela), González-Rivas, J.P. (Juan P.), González-Villalpando, C. (Clicerio), González-Villalpando, M.E. (María Elena), Gonzalez, A.R. (Angel R.), Gottrand, F., Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Grosso, G. (Giuseppe), Gruden, G. (Gabriella), Gu, D. (Dongfeng), Guallar-castillón, P. (Pilar), Guan, O.P. (Ong Peng), Gudmundsson, E.F. (Elias F.), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Gunnlaugsdottir, J. (Johanna), Gupta, R. (Rajeev), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Ha, S. (Seongjun), Hadaegh, F. (Farzad), Haghshenas, R. (Rosa), Hakimi, H. (Hamid), Hambleton, I.R. (Ian R.), Hamzeh, B. (Behrooz), Hantunen, S. (Sari), Kumar, R.H. (Rachakulla Hari), Hashemi-Shahri, S.M. (Seyed Mohammad), Hata, J. (Jun), Haugsgjerd, T. (Teresa), Hayes, A.J. (Alison J.), He, J. (Jiang), He, Y. (Yong), Hendriks, M.E. (Marleen), Henriques, A. (Ana), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hill, A.G. (Allan G.), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Homayounfar, R. (Reza), Hopman, W.M. (Wilma M.), Horimoto, A.R.V.R. (Andrea R. V. R.), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Huerta, J.M. (José María), Huhtaniemi, I.T. (I.), Huisman, M. (Martijn), Hunsberger, M.L. (Monica L.), Husseini, A. (Abdullatif), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen), Wong, N.I. (Norazizah Ibrahim), Iglesia, I. (Iris), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Iotova, V. (Violeta), Irazola, V.E. (Vilma E.), Ishida, T. (Takafumi), Islam, M. (Muhammad), al-Safi Ismail, A. (Aziz), Iwasaki, M. (Masanori), Jacobs, J.M. (Jeremy M.), Jaddou, H.Y. (Hashem Y.), Jafar, T.H. (Tazeen), James, K. (Kenneth), Jamrozik, K., Janszky, I. (Imre), Janus, E. (Edward), Jarvelin, M.-R. (Marjo-Riitta), Jasienska, G. (Grazyna), Jelakovic, A. (Ana), Jelakovic, B. (Bojan), Jennings, G. (Garry), Jensen, G.B. (Gorm), Jeong, S.-L. (Seung-lyeal), Jha, A.K. (Anjani Kumar), Jiang, C.Q. (Chao Qiang), Jimenez, R.O. (Ramon O.), JöCkel, K.-H. (Karl-Heinz), Joffres, M. (Michel), Jokelainen, J.J. (Jari J.), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Joukar, F. (Farahnaz), Józwiak, J. (Jacek), Juolevi, A. (Anne), Kafatos, A. (Anthony), Kajantie, E. (Eero), Kalter-Leibovici, O. (Ofra), Kamaruddin, N.A. (Nor Azmi), Kamstrup, P.R. (Pia R.), Karki, K.B. (Khem B.), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, M. (Mark), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Keramati, M. (Maryam), Kerimkulova, A. (Alina), Kersting, M. (Mathilde), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khateeb, M. (Mohammad), Kheradmand, M. (Motahareh), Khosravi, A. (Alireza), Kiechl-Kohlendorfer, U. (Ursula), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, H.C. (Hyeon Chang), Kim, J. (Jeongseon), Kim, Y.-Y. (Yeon-Yong), Klumbiene, J. (Jurate), Knoflach, M. (Michael), Ko, S. (Stephanie), Kohler, H.-P. (Hans-Peter), Kohler, I.V. (Iliana V.), Kolle, E. (Elin), Kolsteren, P. (Patrick), König, J. (Jürgen), Korpelainen, R. (Raija), Korrovits, P. (Paul), Kos, J. (Jelena), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Kowlessur, S. (Sudhir), Kratzer, W. (Wolfgang), Kriemler, S. (Susi), Kristensen, P.L. (Peter Lund), Krokstad, S. (Steiner), Kromhout, D. (Daan), Kujala, U.M. (Urho), Kurjata, P. (Pawel), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Lambrinou, C.-P. (Christina-Paulina), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Latt, T.S. (Tint Swe), Laugsand, L.E. (Lars E.), Lazo-Porras, M. (Maria), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehmann, N. (Nils), Lehtimäki, T. (Terho), Levitt, N.S. (Naomi S.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (Maria Fernanda), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Lin, Y.-T. (Yi-Ting), Kao, W.H.L. (Wen), Linneberg, A. (Allan), Lissner, L. (Lauren), Liu, J. (Jing), Loit, H.-M. (Helle-Mai), Lopez-Garcia, E. (Esther), Lopez, T. (Tania), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lundqvist, R. (Robert), Lunet, N. (Nuno), Ma, G. (Guansheng), Machado-Coelho, G.L.L. (George L. L.), Machado-Rodrigues, A.M. (Aristides M.), Machi, S. (Suka), Madar, A.A. (Ahmed A.), Maggi, S. (Stefania), Magliano, D.J., Magriplis, E. (Emmanuella), Mahasampath, G. (Gowri), Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, F. (Fatemeh), Malekzadeh, R. (Reza), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Mansour-Ghanaei, F. (Fariborz), Manzato, E. (Enzo), Marques-Vidal, P. (Pedro), Martorell, R. (Reynaldo), Mascarenhas, L.P. (Luis P.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mavrogianni, C. (Christina), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McLean, S.B. (Scott B.), McNulty, B.A. (Breige A.), Mediene-Benchekor, S. (Sounnia), Mehdipour, P. (Parinaz), Mehlig, K. (Kirsten), Mehrparvar, A.H. (Amir Houshang), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana M.B.), Menon, G.R. (Geetha R.), Merat, S. (Shahin), Mereke, A. (Alibek), Meshram, I.I. (Indrapal I.), Metcalf, P. (Patricia), Meyer, H.E. (Haakon E.), Mi, J. (Jie), Michels, N. (Nathalie), Miller, J.C. (Jody C.), Minderico, C.S. (Cláudia S.), Mini, G.K. (G. K.), Miquel, J.F. (Juan Francisco), Miranda, J.J. (J. Jaime), Mirjalili, M.R. (Mohammad Reza), Mirrakhimov, E. (Erkin), Modesti, P.A. (Pietro A.), Moghaddam, S.S. (Sahar Saeedi), Mohajer, B. (Bahram), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadi, Z. (Zahra), Mohammadifard, N. (Noushin), Mohammadpourhodki, R. (Reza), Mohan, V. (Viswanathan), Mohanna, S. (Salim), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Mohebbi, I. (Iraj), Mohebi, F. (Farnam), Moitry, M. (Marie), Møllehave, L.T. (Line T.), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Momenan, A. (Amirabbas), Mondo, C.K. (Charles K.), Monterrubio-Flores, E. (Eric), Moosazadeh, M. (Mahmood), Morejon, A. (Alain), Moreno, L. (Luis), Morgan, K. (Karen), Morin, S.N. (Suzanne N.), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Msyamboza, K.P. (Kelias P.), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Mursu, J. (Jaakko), Mustafa, N. (Norlaila), Nabipour, I. (Iraj), Naderimagham, S. (Shohreh), Nagel, G. (Gabriele), Naidu, B.M. (Balkish M.), Najafi, F. (Farid), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, V.B. (Vinay B.), Nauck, M. (Matthias), Neal, W.A. (William A.), Nejatizadeh, A. (Azim), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Nihal, T. (Thomas), Niiranen, T.J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Noale, M. (Marianna), Noboa, O.A. (Oscar A.), Noto, D. (Davide), Nsour, M.A. (Mohannad Al), Nuhoğlu, I. (Irfan), O’Neill, T.W. (Terence W.), O’Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Ohtsuka, R. (Ryutaro), Olafsson, Ö. (Örn), Olié, V. (Valérie), Oliveira, I.O. (Isabel O.), Omar, M.A. (Mohd Azahadi), Onat, A. (Altan), Ong, S.K. (Sok King), Ordunez, P. (Pedro), Ornelas, R. (Rui), Ortiz, P.J. (Pedro J.), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Ostovar, A. (Afshin), Otero, J.A. (Johanna A.), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palmieri, L. (Luigi), Pan, W.-H. (Wen-Harn), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Patel, N.D. (Nikhil D.), Peer, N. (Nasheeta), Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Peters, A. (Annette), Petersmann, A. (Astrid), Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pichardo, R.N. (Rafael N.), Pigeot, I. (Iris), Pilav, A. (Aida), Pilotto, A. (Alberto), Piwonska, A. (Aleksandra), Pizarro, A.N. (Andreia N.), Plans-Rubió, P. (Pedro), Plata, S. (Silvia), Pohlabeln, H. (Hermann), Porta, M. (Miquel), Portegies, M.L.P. (Marileen), Poudyal, A. (Anil), Pourfarzi, F. (Farhad), Poustchi, H. (Hossein), Pradeepa, R. (Rajendra), Price, J.F. (Jacqueline F.), Providencia, R. (Rui), Puder, J.J. (Jardena J.), Puhakka, S.E. (Soile E.), Punab, M. (Margus), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radisauskas, R. (Ricardas), Rahimikazerooni, S. (Salar), Raitakari, O. (Olli), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramos, E. (Elisabete), Ramos, R. (Rafel), Rampal, L. (Lekhraj), Rampal, S. (Sanjay), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Revilla, L. (Luis), Rezaianzadeh, A. (Abbas), Ribeiro, R. (Robespierre), Richter, A. (Adrian), Rigo, F. (Fernando), Rinke de Wit, T.F. (Tobias), Rodríguez Artalejo, F. (Fernando), del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Roggenbuck, U. (Ulla), Rojas-Martinez, R. (Rosalba), Romaguera, D. (Dora), Romeo, E.L. (Elisabetta L.), Rosengren, A. (Annika), Roy, J.G.R. (Joel G. R.), Rubinstein, A. (Adolfo), Ruidavets, J.-B. (Jean-Bernard), Ruiz-Betancourt, B.S. (Blanca Sandra), Russo, P. (Paola), Rust, P. (Petra), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Sadjadi, A. (Alireza), Safarpour, A.R. (Ali Reza), Safiri, S. (Saeid), Saidi, O. (Olfa), Saki, N. (Nader), Salanave, B. (Benoit), Salmerón, D. (Diego), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sans, S. (Susana), Santaliestra-Pasías, A.M. (Alba M.), Santos, D.A. (Diana A.), Santos, M.P. (Maria Paula), Santos, R. (Rute), Saramies, J.L. (Jouko L.), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Sawada, N. (Norie), Sbaraini, M. (Mariana), Scazufca, M. (Marcia), Schaan, B.D. (Beatriz D.), Schargrodsky, H. (Herman), Scheidt-Nave, C. (C.), Schienkiewitz, A. (Anja), Schipf, S. (Sabine), Schmidt, C.O. (Carsten O.), Schöttker, B. (Ben), Schramm, S. (Sara), Sebert, S. (Sylvain), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Sepanlou, S.G. (Sadaf G), Servais, J. (Jennifer), Shakeri, R. (Ramin), Shalnova, S.A. (Svetlana A.), Shamah-Levy, T. (Teresa), Sharafkhah, M. (Maryam), Sharma, S.K. (Sanjib K.), Shaw, J.E., Shayanrad, A. (Amaneh), Shi, Z. (Zumin), Shibuya, K. (Kenji), Shimizu-Furusawa, H. (Hana), Shin, D.W. (Dong Wook), Shin, Y. (Youchan), Shirani, M. (Majid), Shiri, R. (Rahman), Shrestha, N. (Namuna), Si-Ramlee, K. (Khairil), Siani, A. (Alfonso), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjöström, M. (Michael), Skaaby, T. (Tea), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Snijder, M.B. (Marieke), Söderberg, S. (Stefan), Soemantri, A. (Augustinus), Sofat, R. (Reecha), Solfrizzi, V. (Vincenzo), Somi, M.H. (Mohammad Hossein), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Jérome, C.S. (Charles Sossa), Soumaré, A. (Aicha), Sozmen, K. (Kaan), Sparrenberger, K. (Karen), Staessen, J.A. (Jan), Stathopoulou, M.G. (Maria G), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stessman, J. (Jochanan), Stevanović, R. (Ranko), Stieber, J. (Jutta), Stöckl, D. (Doris), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Suárez-Medina, R. (Ramón), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Suriyawongpaisal, P. (Paibul), Sy, R.G. (Rody G.), Sylva, R.C. (René Charles), Szklo, M. (Moyses), Tai, E.S. (Shyong), Tamosiunas, A. (Abdonas), Tan, E.J. (Eng Joo), Tarawneh, M.R. (Mohammed Rasoul), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Taylor, J. (Julie), Tell, G.S. (Grethe S.), Tello, T. (Tania), Thankappan, K.R. (K. R.), Thijs, L. (Lutgarde), Thuesen, B.H. (Betina H.), Toft, U. (Ulla), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne), Topbas, M. (Murat), Topór-Madry, R. (Roman), Tormo, M.J., Tornaritis, M.J. (Michael J.), Torrent, M. (Maties), Torres-Collado, L. (Laura), Traissac, P. (Pierre), Trinh, O.T.H. (Oanh T. H.), Truthmann, J. (Julia), Tsugane, S. (Shoichiro), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tybjaerg-Hansen, A. (Anne), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H., Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), Dam, R.M. (Rob) van, Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Rossem, L. (Lenie) van, Schoor, N.M. (Natasja) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Varbo, A. (Anette), Varona-Pérez, P. (Patricia), Vasan, S.K. (Senthil K.), Vatten, L. (Lars), Vega, T. (Tomas), Veidebaum, T. (Toomas), Velasquez-Melendez, G. (Gustavo), Venero-Fernández, S.J. (Silvia J.), Veronesi, G. (Giovanni), Verschuren, W.M.M. (W. M. Monique), Victora, C.G. (Cesar G.), Vidiawati, D. (Dhanasari), Viet, L. (Lucie), Villalpando, S. (Salvador), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vlasoff, T. (Tiina), Vollenweider, P. (Peter), Voutilainen, A. (Ari), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Bebakar, W.M.W. (Wan Mohamad Wan), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, N. (Ningli), Wang, Q. (Qian), Wang, Y.X. (Ya Xing), Wang, Y.-W. (Ying-Wei), Wannamethee, S.G. (Goya), Wedderkopp, N. (Niels), Wei, W. (Wenbin), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Willeit, P. (Peter), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong-McClure, R.A. (Roy A.), Wong, A. (Andrew), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, S. (Shouling), Xu, H. (Haiquan), Xu, L. (Liang), Yan, W. (Weili), Yang, X. (Xiaoguang), Yasuharu, T. (Tabara), Ye, X. (Xingwang), Yeow, T.P. (Toh Peng), Yiallouros, P.K. (P.), Yoosefi, M. (Moein), Yoshihara, A. (Akihiro), You, S.-L. (San-Lin), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad Faudzi), Zainuddin, A.A. (Ahmad A.), Zakavi, S.R. (Seyed Rasoul), Zali, M.R. (Mohammad Reza), Zamani, F. (Farhad), Zambon, S. (Sabina), Zampelas, A. (Antonis), Zaw, K.K. (Ko Ko), Zdrojewski, T. (T.), Vrkic, T.Z. (Tajana Zeljkovic), Zhang, Z.-Y. (Zhen-Yu), Zhao, W. (Wenhua), Zhen, S. (Shiqi), Zheng, Y. (Yingfeng), Zholdin, B. (Bekbolat), Zhussupov, B. (Baurzhan), Zoghlami, N. (Nada), Cisneros, J.Z. (Julio Zuñiga), Gregg, E.W. (Edward W.), Ezzati, M. (Majid), Taddei, C. (Cristina), Zhou, B. (Bin), Bixby, H. (Honor), Carrillo-Larco, R.M. (Rodrigo M.), Danaei, G. (Goodarz), Jackson, R.T. (Rod T.), Farzadfar, F. (Farshad), Sophiea, M.K. (Marisa K.), Di Cesare, M. (Mariachiara), Iurilli, M.L.C. (Maria Laura Caminia), Martinez, A.R. (Andrea Rodriguez), Asghari, G. (Golaleh), Dhana, K. (Klodian), Gulayin, P. (Pablo), Kakarmath, S. (Sujay), Santero, M. (Marilina), Voortman, R.G. (Trudy), Riley, L.M. (Leanne M.), Cowan, M.J. (Melanie J.), Savin, S. (Stefan), Bennett, J.E. (James E.), Stevens, G.A. (Gretchen A.), Paciorek, C.J. (Christopher J.), Aekplakorn, W. (Wichai), Cifkova, R. (Renata), Giampaoli, S. (Simona), Kengne, A.P. (Andre Pascal), Khang, Y.-H. (Young-Ho), Kuulasmaa, K. (Kari), Laxmaiah, A. (Avula), Margozzini, P. (Paula), Mathur, P. (Prashant), Nordestgaard, B.G. (Børge), Zhao, D. (Dong), Aadahl, M. (Mette), Abarca-Gómez, L. (Leandra), Rahim, H.A. (Hanan Abdul), Abu-Rmeileh, N.M. (Niveen M.), Acosta-Cazares, B. (Benjamin), Adams, R.J. (Robert J.), Agdeppa, I.A. (Imelda A.), Aghazadeh-Attari, J. (Javad), Aguilar-Salinas, C.A. (Carlos A.), Agyemang, C.O. (Charles), Ahluwalia, T.S. (Tarunveer Singh), Ahmad, N.A. (Noor Ani), Ahmadi, A. (Ali), Ahmadi, N. (Naser), Ahmed, S.H. (Soheir H.), Ahrens, W. (W.), Ajlouni, K. (Kamel), Alarouj, M. (Monira), AlBuhairan, F. (Fadia), AlDhukair, S. (Shahla), Ali, M.M. (Mohamed M.), Alkandari, A. (Abdullah), Alkerwi, A. (Ala’a), Aly, E. (Eman), Amarapurkar, D.N. (Deepak N.), Amouyel, P. (Philippe), Andersen, L.B. (Lars Bo), Anderssen, S.A. (Sigmund A.), Anjana, R.M. (Ranjit Mohan), Ansari-Moghaddam, A. (Alireza), Aounallah-Skhiri, H. (Hajer), Araújo, J. (Joana), Ariansen, I. (Inger), Aris, T. (Tahir), Arku, R.E. (Raphael E.), Arlappa, N. (Nimmathota), Aryal, K.K. (Krishna K.), Aspelund, T. (Thor), Assunção, M.C.F. (Maria Cecília F.), Auvinen, J. (Juha), Avdicová, M. (Mária), Azevedo, A. (Ana), Azizi, J. (Joshan), Azmin, M. (Mehrdad), Balakrishna, N. (Nagalla), Bamoshmoosh, M. (Mohamed), Banach, M. (Maciej), Bandosz, P. (Piotr), Banegas, J.R. (José R.), Barbagallo, C.M. (Carlo M.), Barceló, A. (Alberto), Barkat, A. (Amina), Bata, I. (Iqbal), Batieha, A.M. (Anwar M.), Batyrbek, A. (Assembekov), Baur, L.A. (Louise A.), Beaglehole, R. (Robert), Belavendra, A. (Antonisamy), Ben Romdhane, H. (Habiba), Benet, M. (Mikhail), Benn, M. (Marianne), Berkinbayev, S. (Salim), Bernabe-Ortiz, A. (Antonio), Bernotiene, G. (Gailute), Bettiol, H. (Heloisa), Bhargava, S.K. (Santosh K.), Bi, Y. (Yufang), Bienek, A. (Asako), Bikbov, M. (Mukharram), Bista, B. (Bihungum), Bjerregaard, P. (Peter), Bjertness, E. (Espen), Bjertness, M.B. (Marius B.), Björkelund, C. (Cecilia), Bloch, K.V. (Katia V.), Blokstra, A. (Anneke), Bo, S. (Simona), Boehm, B.O. (Bernhard O.), Boggia, J.G. (Jose G.), Boissonnet, C.P. (Carlos P.), Bonaccio, M. (Marialaura), Bongard, V. (Vanina), Borchini, R. (Rossana), Borghs, H. (Herman), Bovet, P. (Pascal), Brajkovich, I. (Imperia), Breckenkamp, J. (Juergen), Brenner, H. (Hermann), Brewster, L.M. (Lizzy), Bruno, G. (Graziella), Bugge, A. (Anna), Busch, M.A. (Markus A.), de León, A.C. (Antonio Cabrera), Cacciottolo, J. (Joseph), Can, G. (Günay), Cândido, A.P.C. (Ana Paula C.), Capanzana, M.V. (Mario V.), Capuano, E. (Eduardo), Capuano, V. (Vincenzo), Cardoso, V.C. (Viviane C.), Carvalho, J. (Joana), Casanueva, F.F., Censi, L. (Laura), Chadjigeorgiou, C.A. (Charalambos A.), Chamukuttan, S. (Snehalatha), Chaturvedi, N. (Nish), Chen, C.-J. (Chien-Jen), Chen, F. (Fangfang), Chen, S. (Shuohua), Cheng, C.-Y. (Ching-Yu), Cheraghian, B. (Bahman), Chetrit, A. (Angela), Chiou, S.-T. (Shu-Ti), Chirlaque, M.D. (M.), Cho, B. (Belong), Cho, Y. (Yumi), Chudek, J. (Jerzy), Claessens, F. (Frank), Clarke, J. (Janine), Clays, E. (Els), Concin, H. (Hans), Confortin, S.C. (Susana C.), Cooper, C. (Charles), Costanzo, S. (Simona), Cottel, D. (Dominique), Cowell, C. (Chris), Crujeiras, A.B. (Ana B.), Csilla, S. (Semánová), Cui, L. (Liufu), Cureau, F.V. (Felipe V.), D’Arrigo, G. (Graziella), d’Orsi, E. (Eleonora), Dallongeville, J., Damasceno, A. (Albertino), Dankner, R. (Rachel), Dantoft, T.M. (Thomas M.), Dauchet, L. (Luc), Davletov, K. (Kairat), Backer, G. (Guy) de, Bacquer, D. (Dirk) de, de Gaetano, G. (Giovanni), De Henauw, S. (Stefaan), de Oliveira, P.D. (Paula Duarte), De Ridder, D. (David), De Smedt, D. (Delphine), Deepa, M. (Mohan), Deev, A.D. (Alexander D.), Dehghan, A. (Abbas), Delisle, H. (Hélène), Dennison, E.M. (Elaine), Deschamps, V. (Valérie), Dhimal, M. (Meghnath), Di Castelnuovo, A.F. (Augusto F.), Dika, Z. (Zivka), Djalalinia, S. (Shirin), Dobson, A.J. (Annette J.), Donfrancesco, C. (Chiara), Donoso, S.P. (Silvana P.), Döring, A. (Angela), Dorobantu, M. (Maria), Dragano, N. (Nico), Drygas, W. (Wojciech), Du, Y. (Yong), Duante, C.A. (Charmaine A.), Duda, R.B. (Rosemary B.), Dzerve, V. (Vilnis), Dziankowska-Zaborszczyk, E. (Elzbieta), Eddie, R. (Ricky), Eftekhar, E. (Ebrahim), Eggertsen, R. (Robert), Eghtesad, S. (Sareh), Eiben, G. (Gabriele), Ekelund, U. (Ulf), El Ati, J. (Jalila), Eldemire-Shearer, D. (Denise), Eliasen, M. (Marie), Elosua, R. (Roberto), Erasmus, R.T. (Rajiv T.), Erbel, R. (Raimund), Erem, C. (Cihangir), Eriksen, L. (Louise), Hagen, K. (Knut), Escobedo-de la Peña, J. (Jorge), Eslami, S. (Saeid), Esmaeili, A. (Ali), Evans, A. (Alun), Faeh, D. (David), Fall, C.H. (Caroline H.), Faramarzi, E. (Elnaz), Farjam, M. (Mojtaba), Fattahi, M.R. (Mohammad Reza), Felix-Redondo, F.J. (Francisco J.), Ferguson, T.S. (Trevor S.), Fernández-Bergés, D. (Daniel), Ferrante, D. (Daniel), Ferrari, M. (Marika), Ferreccio, C. (Catterina), Ferrieres, J. (Jean), Föger, B. (Bernhard), Foo, L.H. (Leng Huat), Forslund, A.-S. (Ann-Sofie), Forsner, M. (Maria), Fouad, H.M. (Heba M.), Francis, D.K. (Damian K.), do Carmo Franco, M. (Maria), Franco, O.H. (Oscar H.), Frontera, G. (Guillermo), Fujita, Y. (Yuki), Fumihiko, M. (Matsuda), Furusawa, T. (Takuro), Gaciong, Z. (Zbigniew), Galvano, F. (Fabio), Gao, J. (Jingli), Garcia-de-la-Hera, M. (Manoli), Garnett, S.P. (Sarah P.), Gaspoz, J.-M. (Jean-Michel), Gasull, M. (Magda), Gazzinelli, A. (Andrea), Geleijnse, J.M. (Marianne), Ghanbari, A. (Ali), Ghasemi, E. (Erfan), Gheorghe-Fronea, O.-F. (Oana-Florentina), Ghimire, A. (Anup), Gianfagna, F. (Francesco), Gill, T.K. (Tiffany K.), Giovannelli, J. (Jonathan), Gironella, G. (Glen), Giwercman, A. (Aleksander), Goltzman, D. (David), Gonçalves, H. (Helen), Gonzalez-Chica, D.A. (David A.), Gonzalez-Gross, M. (Marcela), González-Rivas, J.P. (Juan P.), González-Villalpando, C. (Clicerio), González-Villalpando, M.E. (María Elena), Gonzalez, A.R. (Angel R.), Gottrand, F., Graff-Iversen, S. (Sidsel), Grafnetter, D. (Dušan), Gregor, R.D. (Ronald D.), Grodzicki, T. (Tomasz), Grøntved, A. (Anders), Grosso, G. (Giuseppe), Gruden, G. (Gabriella), Gu, D. (Dongfeng), Guallar-castillón, P. (Pilar), Guan, O.P. (Ong Peng), Gudmundsson, E.F. (Elias F.), Gudnason, V. (Vilmundur), Guerrero, R. (Ramiro), Guessous, I. (Idris), Gunnlaugsdottir, J. (Johanna), Gupta, R. (Rajeev), Gutierrez, L. (Laura), Gutzwiller, F. (Felix), Ha, S. (Seongjun), Hadaegh, F. (Farzad), Haghshenas, R. (Rosa), Hakimi, H. (Hamid), Hambleton, I.R. (Ian R.), Hamzeh, B. (Behrooz), Hantunen, S. (Sari), Kumar, R.H. (Rachakulla Hari), Hashemi-Shahri, S.M. (Seyed Mohammad), Hata, J. (Jun), Haugsgjerd, T. (Teresa), Hayes, A.J. (Alison J.), He, J. (Jiang), He, Y. (Yong), Hendriks, M.E. (Marleen), Henriques, A. (Ana), Herrala, S. (Sauli), Heshmat, R. (Ramin), Hill, A.G. (Allan G.), Ho, S.Y. (Sai Yin), Ho, S.C. (Suzanne C.), Hobbs, M. (Michael), Hofman, A. (Albert), Homayounfar, R. (Reza), Hopman, W.M. (Wilma M.), Horimoto, A.R.V.R. (Andrea R. V. R.), Hormiga, C.M. (Claudia M.), Horta, B.L. (Bernardo L.), Houti, L. (Leila), Howitt, C. (Christina), Htay, T.T. (Thein Thein), Htet, A.S. (Aung Soe), Htike, M.M.T. (Maung Maung Than), Huerta, J.M. (José María), Huhtaniemi, I.T. (I.), Huisman, M. (Martijn), Hunsberger, M.L. (Monica L.), Husseini, A. (Abdullatif), Huybrechts, I. (Inge), Hwalla, N. (Nahla), Iacoviello, L. (Licia), Iannone, A.G. (Anna G.), Ibrahim, M.M. (Mohsen), Wong, N.I. (Norazizah Ibrahim), Iglesia, I. (Iris), Ikeda, N. (Nayu), Ikram, M.A. (Arfan), Iotova, V. (Violeta), Irazola, V.E. (Vilma E.), Ishida, T. (Takafumi), Islam, M. (Muhammad), al-Safi Ismail, A. (Aziz), Iwasaki, M. (Masanori), Jacobs, J.M. (Jeremy M.), Jaddou, H.Y. (Hashem Y.), Jafar, T.H. (Tazeen), James, K. (Kenneth), Jamrozik, K., Janszky, I. (Imre), Janus, E. (Edward), Jarvelin, M.-R. (Marjo-Riitta), Jasienska, G. (Grazyna), Jelakovic, A. (Ana), Jelakovic, B. (Bojan), Jennings, G. (Garry), Jensen, G.B. (Gorm), Jeong, S.-L. (Seung-lyeal), Jha, A.K. (Anjani Kumar), Jiang, C.Q. (Chao Qiang), Jimenez, R.O. (Ramon O.), JöCkel, K.-H. (Karl-Heinz), Joffres, M. (Michel), Jokelainen, J.J. (Jari J.), Jonas, J.B. (Jost B.), Jorgensen, T. (Torben), Joshi, P. (Pradeep), Joukar, F. (Farahnaz), Józwiak, J. (Jacek), Juolevi, A. (Anne), Kafatos, A. (Anthony), Kajantie, E. (Eero), Kalter-Leibovici, O. (Ofra), Kamaruddin, N.A. (Nor Azmi), Kamstrup, P.R. (Pia R.), Karki, K.B. (Khem B.), Katz, J. (Joanne), Kauhanen, J. (Jussi), Kaur, P. (Prabhdeep), Kavousi, M. (Maryam), Kazakbaeva, G. (Gyulli), Keil, M. (Mark), Keinanen-Kiukaanniemi, S. (Sirkka), Kelishadi, R. (Roya), Keramati, M. (Maryam), Kerimkulova, A. (Alina), Kersting, M. (Mathilde), Khader, Y.S. (Yousef Saleh), Khalili, D. (Davood), Khateeb, M. (Mohammad), Kheradmand, M. (Motahareh), Khosravi, A. (Alireza), Kiechl-Kohlendorfer, U. (Ursula), Kiechl, S. (Stefan), Killewo, J. (Japhet), Kim, H.C. (Hyeon Chang), Kim, J. (Jeongseon), Kim, Y.-Y. (Yeon-Yong), Klumbiene, J. (Jurate), Knoflach, M. (Michael), Ko, S. (Stephanie), Kohler, H.-P. (Hans-Peter), Kohler, I.V. (Iliana V.), Kolle, E. (Elin), Kolsteren, P. (Patrick), König, J. (Jürgen), Korpelainen, R. (Raija), Korrovits, P. (Paul), Kos, J. (Jelena), Koskinen, S. (Seppo), Kouda, K. (Katsuyasu), Kowlessur, S. (Sudhir), Kratzer, W. (Wolfgang), Kriemler, S. (Susi), Kristensen, P.L. (Peter Lund), Krokstad, S. (Steiner), Kromhout, D. (Daan), Kujala, U.M. (Urho), Kurjata, P. (Pawel), Kyobutungi, C. (Catherine), Laamiri, F.Z. (Fatima Zahra), Laatikainen, T. (Tiina), Lachat, C. (Carl), Laid, Y. (Youcef), Lam, T.H. (Tai Hing), Lambrinou, C.-P. (Christina-Paulina), Lanska, V. (Vera), Lappas, G. (Georg), Larijani, B. (Bagher), Latt, T.S. (Tint Swe), Laugsand, L.E. (Lars E.), Lazo-Porras, M. (Maria), Lee, J. (Jeannette), Lee, J. (Jeonghee), Lehmann, N. (Nils), Lehtimäki, T. (Terho), Levitt, N.S. (Naomi S.), Li, Y. (Yanping), Lilly, C.L. (Christa L.), Lim, W.-Y. (Wei-Yen), Lima-Costa, M.F. (Maria Fernanda), Lin, H.-H. (Hsien-Ho), Lin, X. (Xu), Lin, Y.-T. (Yi-Ting), Kao, W.H.L. (Wen), Linneberg, A. (Allan), Lissner, L. (Lauren), Liu, J. (Jing), Loit, H.-M. (Helle-Mai), Lopez-Garcia, E. (Esther), Lopez, T. (Tania), Lotufo, P.A. (Paulo A), Lozano, J.E. (José Eugenio), Luksiene, D. (Dalia), Lundqvist, A. (Annamari), Lundqvist, R. (Robert), Lunet, N. (Nuno), Ma, G. (Guansheng), Machado-Coelho, G.L.L. (George L. L.), Machado-Rodrigues, A.M. (Aristides M.), Machi, S. (Suka), Madar, A.A. (Ahmed A.), Maggi, S. (Stefania), Magliano, D.J., Magriplis, E. (Emmanuella), Mahasampath, G. (Gowri), Maire, B. (Bernard), Makdisse, M. (Marcia), Malekzadeh, F. (Fatemeh), Malekzadeh, R. (Reza), Rao, K.M. (Kodavanti Mallikharjuna), Manios, Y., Mann, J.I. (Jim I.), Mansour-Ghanaei, F. (Fariborz), Manzato, E. (Enzo), Marques-Vidal, P. (Pedro), Martorell, R. (Reynaldo), Mascarenhas, L.P. (Luis P.), Mathiesen, E.B. (Ellisiv), Matsha, T.E. (Tandi E.), Mavrogianni, C. (Christina), McFarlane, S.R. (Shelly R.), McGarvey, S.T. (Stephen T.), McLachlan, S. (Stela), McLean, R.M. (Rachael M.), McLean, S.B. (Scott B.), McNulty, B.A. (Breige A.), Mediene-Benchekor, S. (Sounnia), Mehdipour, P. (Parinaz), Mehlig, K. (Kirsten), Mehrparvar, A.H. (Amir Houshang), Meirhaeghe, A. (Aline), Meisinger, C. (Christa), Menezes, A.M.B. (Ana M.B.), Menon, G.R. (Geetha R.), Merat, S. (Shahin), Mereke, A. (Alibek), Meshram, I.I. (Indrapal I.), Metcalf, P. (Patricia), Meyer, H.E. (Haakon E.), Mi, J. (Jie), Michels, N. (Nathalie), Miller, J.C. (Jody C.), Minderico, C.S. (Cláudia S.), Mini, G.K. (G. K.), Miquel, J.F. (Juan Francisco), Miranda, J.J. (J. Jaime), Mirjalili, M.R. (Mohammad Reza), Mirrakhimov, E. (Erkin), Modesti, P.A. (Pietro A.), Moghaddam, S.S. (Sahar Saeedi), Mohajer, B. (Bahram), Mohamed, M.K. (Mostafa K.), Mohammad, K. (Kazem), Mohammadi, Z. (Zahra), Mohammadifard, N. (Noushin), Mohammadpourhodki, R. (Reza), Mohan, V. (Viswanathan), Mohanna, S. (Salim), Yusoff, M.F.M. (Muhammad Fadhli Mohd), Mohebbi, I. (Iraj), Mohebi, F. (Farnam), Moitry, M. (Marie), Møllehave, L.T. (Line T.), Møller, N.C. (Niels C.), Molnár, D. (Dénes), Momenan, A. (Amirabbas), Mondo, C.K. (Charles K.), Monterrubio-Flores, E. (Eric), Moosazadeh, M. (Mahmood), Morejon, A. (Alain), Moreno, L. (Luis), Morgan, K. (Karen), Morin, S.N. (Suzanne N.), Moschonis, G. (George), Mossakowska, M. (Malgorzata), Mostafa, A. (Aya), Mota, J. (Jorge), Motlagh, M.E. (Mohammad Esmaeel), Motta, J. (Jorge), Msyamboza, K.P. (Kelias P.), Muiesan, M.L. (Maria Lorenza), Müller-Nurasyid, M. (Martina), Mursu, J. (Jaakko), Mustafa, N. (Norlaila), Nabipour, I. (Iraj), Naderimagham, S. (Shohreh), Nagel, G. (Gabriele), Naidu, B.M. (Balkish M.), Najafi, F. (Farid), Nakamura, H. (Harunobu), Námešná, J. (Jana), Nang, E.E.K. (Ei Ei K.), Nangia, V.B. (Vinay B.), Nauck, M. (Matthias), Neal, W.A. (William A.), Nejatizadeh, A. (Azim), Nenko, I. (Ilona), Nervi, F. (Flavio), Nguyen, N.D. (Nguyen D.), Nguyen, Q.N. (Quang Ngoc), Nieto-Martínez, R.E. (Ramfis E.), Nihal, T. (Thomas), Niiranen, T.J. (Teemu J.), Ning, G. (Guang), Ninomiya, T. (Toshiharu), Noale, M. (Marianna), Noboa, O.A. (Oscar A.), Noto, D. (Davide), Nsour, M.A. (Mohannad Al), Nuhoğlu, I. (Irfan), O’Neill, T.W. (Terence W.), O’Reilly, D. (Dermot), Ochoa-Avilés, A.M. (Angélica M.), Oh, K. (Kyungwon), Ohtsuka, R. (Ryutaro), Olafsson, Ö. (Örn), Olié, V. (Valérie), Oliveira, I.O. (Isabel O.), Omar, M.A. (Mohd Azahadi), Onat, A. (Altan), Ong, S.K. (Sok King), Ordunez, P. (Pedro), Ornelas, R. (Rui), Ortiz, P.J. (Pedro J.), Osmond, C. (Clive), Ostojic, S.M. (Sergej M.), Ostovar, A. (Afshin), Otero, J.A. (Johanna A.), Owusu-Dabo, E. (Ellis), Paccaud, F.M. (Fred Michel), Pahomova, E. (Elena), Pajak, A. (Andrzej), Palmieri, L. (Luigi), Pan, W.-H. (Wen-Harn), Panda-Jonas, S. (Songhomitra), Panza, F. (Francesco), Parnell, W.R. (Winsome R.), Patel, N.D. (Nikhil D.), Peer, N. (Nasheeta), Peixoto, S.V. (Sergio Viana), Peltonen, M. (Markku), Pereira, A. (A.), Peters, A. (Annette), Petersmann, A. (Astrid), Petkeviciene, J. (Janina), Peykari, N. (Niloofar), Pham, S.T. (Son Thai), Pichardo, R.N. (Rafael N.), Pigeot, I. (Iris), Pilav, A. (Aida), Pilotto, A. (Alberto), Piwonska, A. (Aleksandra), Pizarro, A.N. (Andreia N.), Plans-Rubió, P. (Pedro), Plata, S. (Silvia), Pohlabeln, H. (Hermann), Porta, M. (Miquel), Portegies, M.L.P. (Marileen), Poudyal, A. (Anil), Pourfarzi, F. (Farhad), Poustchi, H. (Hossein), Pradeepa, R. (Rajendra), Price, J.F. (Jacqueline F.), Providencia, R. (Rui), Puder, J.J. (Jardena J.), Puhakka, S.E. (Soile E.), Punab, M. (Margus), Qorbani, M. (Mostafa), Bao, T.Q. (Tran Quoc), Radisauskas, R. (Ricardas), Rahimikazerooni, S. (Salar), Raitakari, O. (Olli), Rao, S.R. (Sudha Ramachandra), Ramachandran, A. (Ambady), Ramos, E. (Elisabete), Ramos, R. (Rafel), Rampal, L. (Lekhraj), Rampal, S. (Sanjay), Redón, J. (Josep), Reganit, P.F.M. (Paul Ferdinand M.), Revilla, L. (Luis), Rezaianzadeh, A. (Abbas), Ribeiro, R. (Robespierre), Richter, A. (Adrian), Rigo, F. (Fernando), Rinke de Wit, T.F. (Tobias), Rodríguez Artalejo, F. (Fernando), del Cristo Rodriguez-Perez, M. (María), Rodríguez-Villamizar, L.A. (Laura A.), Roggenbuck, U. (Ulla), Rojas-Martinez, R. (Rosalba), Romaguera, D. (Dora), Romeo, E.L. (Elisabetta L.), Rosengren, A. (Annika), Roy, J.G.R. (Joel G. R.), Rubinstein, A. (Adolfo), Ruidavets, J.-B. (Jean-Bernard), Ruiz-Betancourt, B.S. (Blanca Sandra), Russo, P. (Paola), Rust, P. (Petra), Rutkowski, M. (Marcin), Sabanayagam, C. (Charumathi), Sachdev, H.S. (Harshpal S.), Sadjadi, A. (Alireza), Safarpour, A.R. (Ali Reza), Safiri, S. (Saeid), Saidi, O. (Olfa), Saki, N. (Nader), Salanave, B. (Benoit), Salmerón, D. (Diego), Salomaa, V. (Veikko), Salonen, J.T. (Jukka T.), Salvetti, M. (Massimo), Sánchez-Abanto, J. (Jose), Sans, S. (Susana), Santaliestra-Pasías, A.M. (Alba M.), Santos, D.A. (Diana A.), Santos, M.P. (Maria Paula), Santos, R. (Rute), Saramies, J.L. (Jouko L.), Sardinha, L.B. (Luis B.), Sarrafzadegan, N. (Nizal), Saum, K.-U. (Kai-Uwe), Savva, S., Sawada, N. (Norie), Sbaraini, M. (Mariana), Scazufca, M. (Marcia), Schaan, B.D. (Beatriz D.), Schargrodsky, H. (Herman), Scheidt-Nave, C. (C.), Schienkiewitz, A. (Anja), Schipf, S. (Sabine), Schmidt, C.O. (Carsten O.), Schöttker, B. (Ben), Schramm, S. (Sara), Sebert, S. (Sylvain), Sein, A.A. (Aye Aye), Sen, A. (Abhijit), Sepanlou, S.G. (Sadaf G), Servais, J. (Jennifer), Shakeri, R. (Ramin), Shalnova, S.A. (Svetlana A.), Shamah-Levy, T. (Teresa), Sharafkhah, M. (Maryam), Sharma, S.K. (Sanjib K.), Shaw, J.E., Shayanrad, A. (Amaneh), Shi, Z. (Zumin), Shibuya, K. (Kenji), Shimizu-Furusawa, H. (Hana), Shin, D.W. (Dong Wook), Shin, Y. (Youchan), Shirani, M. (Majid), Shiri, R. (Rahman), Shrestha, N. (Namuna), Si-Ramlee, K. (Khairil), Siani, A. (Alfonso), Siantar, R. (Rosalynn), Sibai, A.M. (Abla M.), Silva, D.A.S. (Diego Augusto Santos), Simon, M. (Mary), Simons, J. (Judith), Simons, L.A. (Leon A.), Sjöström, M. (Michael), Skaaby, T. (Tea), Slowikowska-Hilczer, J. (Jolanta), Slusarczyk, P. (Przemyslaw), Smeeth, L. (Liam), Snijder, M.B. (Marieke), Söderberg, S. (Stefan), Soemantri, A. (Augustinus), Sofat, R. (Reecha), Solfrizzi, V. (Vincenzo), Somi, M.H. (Mohammad Hossein), Sonestedt, E. (Emily), Sørensen, T.I.A. (Thorkild), Jérome, C.S. (Charles Sossa), Soumaré, A. (Aicha), Sozmen, K. (Kaan), Sparrenberger, K. (Karen), Staessen, J.A. (Jan), Stathopoulou, M.G. (Maria G), Stavreski, B. (Bill), Steene-Johannessen, J. (Jostein), Stehle, P. (Peter), Stein, A.D. (Aryeh D.), Stessman, J. (Jochanan), Stevanović, R. (Ranko), Stieber, J. (Jutta), Stöckl, D. (Doris), Stokwiszewski, J. (Jakub), Stronks, K. (Karien), Strufaldi, M.W. (Maria Wany), Suárez-Medina, R. (Ramón), Sun, C.-A. (Chien-An), Sundström, J. (Johan), Suriyawongpaisal, P. (Paibul), Sy, R.G. (Rody G.), Sylva, R.C. (René Charles), Szklo, M. (Moyses), Tai, E.S. (Shyong), Tamosiunas, A. (Abdonas), Tan, E.J. (Eng Joo), Tarawneh, M.R. (Mohammed Rasoul), Tarqui-Mamani, C.B. (Carolina B.), Taylor, A. (Anne), Taylor, J. (Julie), Tell, G.S. (Grethe S.), Tello, T. (Tania), Thankappan, K.R. (K. R.), Thijs, L. (Lutgarde), Thuesen, B.H. (Betina H.), Toft, U. (Ulla), Tolonen, H.K. (Hanna K.), Tolstrup, J.S. (Janne), Topbas, M. (Murat), Topór-Madry, R. (Roman), Tormo, M.J., Tornaritis, M.J. (Michael J.), Torrent, M. (Maties), Torres-Collado, L. (Laura), Traissac, P. (Pierre), Trinh, O.T.H. (Oanh T. H.), Truthmann, J. (Julia), Tsugane, S. (Shoichiro), Tulloch-Reid, M.K. (Marshall K.), Tuomainen, T.-P. (Tomi-Pekka), Tuomilehto, J. (Jaakko), Tybjaerg-Hansen, A. (Anne), Tzourio, C. (Christophe), Ueda, P. (Peter), Ugel, E. (Eunice), Ulmer, H. (Hanno), Unal, B. (Belgin), Uusitalo, H., Valdivia, G. (Gonzalo), Valvi, D. (Damaskini), Dam, R.M. (Rob) van, Schouw, Y.T. (Yvonne) van der, Van Herck, K. (Koen), Van Minh, H. (Hoang), Rossem, L. (Lenie) van, Schoor, N.M. (Natasja) van, Valkengoed, I. (Irene) van, Vanderschueren, D. (Dirk), Vanuzzo, D. (Diego), Varbo, A. (Anette), Varona-Pérez, P. (Patricia), Vasan, S.K. (Senthil K.), Vatten, L. (Lars), Vega, T. (Tomas), Veidebaum, T. (Toomas), Velasquez-Melendez, G. (Gustavo), Venero-Fernández, S.J. (Silvia J.), Veronesi, G. (Giovanni), Verschuren, W.M.M. (W. M. Monique), Victora, C.G. (Cesar G.), Vidiawati, D. (Dhanasari), Viet, L. (Lucie), Villalpando, S. (Salvador), Vioque, J. (Jesus), Virtanen, J.K. (Jyrki K.), Visvikis-Siest, S. (Sophie), Viswanathan, B. (Bharathi), Vlasoff, T. (Tiina), Vollenweider, P. (Peter), Voutilainen, A. (Ari), Wade, A.N. (Alisha N.), Wagner, A. (Aline), Walton, J. (Janette), Bebakar, W.M.W. (Wan Mohamad Wan), Mohamud, W.N.W. (Wan Nazaimoon Wan), Wang, M.-D. (Ming-Dong), Wang, N. (Ningli), Wang, Q. (Qian), Wang, Y.X. (Ya Xing), Wang, Y.-W. (Ying-Wei), Wannamethee, S.G. (Goya), Wedderkopp, N. (Niels), Wei, W. (Wenbin), Whincup, P.H. (Peter), Widhalm, K. (Kurt), Widyahening, I.S. (Indah S.), Wiecek, A. (Andrzej), Wijga, A.H. (Alet), Wilks, R.J. (Rainford J.), Willeit, J. (Johann), Willeit, P. (Peter), Wilsgaard, T. (Tom), Wojtyniak, B. (Bogdan), Wong-McClure, R.A. (Roy A.), Wong, A. (Andrew), Wong, T.Y. (Tien Yin), Woo, J. (Jean), Woodward, M. (Mark), Wu, F.C. (Frederick C.), Wu, S. (Shouling), Xu, H. (Haiquan), Xu, L. (Liang), Yan, W. (Weili), Yang, X. (Xiaoguang), Yasuharu, T. (Tabara), Ye, X. (Xingwang), Yeow, T.P. (Toh Peng), Yiallouros, P.K. (P.), Yoosefi, M. (Moein), Yoshihara, A. (Akihiro), You, S.-L. (San-Lin), Younger-Coleman, N.O. (Novie O.), Yusoff, A.F. (Ahmad Faudzi), Zainuddin, A.A. (Ahmad A.), Zakavi, S.R. (Seyed Rasoul), Zali, M.R. (Mohammad Reza), Zamani, F. (Farhad), Zambon, S. (Sabina), Zampelas, A. (Antonis), Zaw, K.K. (Ko Ko), Zdrojewski, T. (T.), Vrkic, T.Z. (Tajana Zeljkovic), Zhang, Z.-Y. (Zhen-Yu), Zhao, W. (Wenhua), Zhen, S. (Shiqi), Zheng, Y. (Yingfeng), Zholdin, B. (Bekbolat), Zhussupov, B. (Baurzhan), Zoghlami, N. (Nada), Cisneros, J.Z. (Julio Zuñiga), Gregg, E.W. (Edward W.), and Ezzati, M. (Majid)
- Abstract
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiov
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- 2020
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45. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition
- Author
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IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., Duell, E.J., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., and Duell, E.J.
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- 2020
46. National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries
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Taddei, C, Jackson, R, Zhou, B, Bixby, H, Danaei, G, Di Cesare, M, Kuulasmaa, K, Hajifathalian, K, Bentham, J, Bennett, JE, Aekplakorn, W, Cifkova, R, Dallongeville, J, DeBacquer, D, Giampaoli, S, Gudnason, V, Khang, Y-H, Laatikainen, T, Mann, J, Marques-Vidal, P, Mensah, GA, Mueller-Nurasyid, M, Ninomiya, T, Petkeviciene, J, Rodriguez-Artalejo, F, Servais, J, Soderberg, S, Stavreski, B, Wilsgaard, T, Zdrojewski, T, Zhao, D, Stevens, GA, Savin, S, Cowan, MJ, Riley, LM, Ezzati, M, Adams, RJ, Ahrens, W, Amouyel, P, Amuzu, A, Anderssen, SA, Ariansen, I, Arveiler, D, Aspelund, T, Auvinen, J, Avdicova, M, Banach, M, Bandosz, P, Banegas, JR, Barbagallo, CM, Bata, I, Baur, LA, Beaglehole, R, Bernotiene, G, Bi, Y, Bienek, A, Bjorkelund, C, Bo, S, Boehm, BO, Bonaccio, M, Bongard, V, Borchini, R, Borghs, H, Breckenkamp, J, Brenner, H, Bruno, G, Busch, MA, Cabrera de Leon, A, Capuano, V, Casanueva, FF, Casas, J-P, Caserta, CA, Censi, L, Chen, F, Chen, S, Chirlaque, M-D, Cho, B, Cho, Y, Chudek, J, Claessens, F, Clarke, J, Clays, E, Cooper, C, Costanzo, S, Cottel, D, Cowell, C, Crujeiras, AB, Cui, L, D'Arrigo, G, Dauchet, L, De Backer, G, De Bacquer, D, de Gaetano, G, De Henauw, S, De Smedt, D, Dennison, E, Deschamps, V, Di Castelnuovo, A, Dobson, AJ, Donfrancesco, C, Doering, A, Drygas, W, Du, Y, Dziankowska-Zaborszczyk, E, Eggertsen, R, Ekelund, U, Elosua, R, Eriksson, JG, Evans, A, Faeh, D, Felix-Redondo, FJ, Fernandez-Berges, D, Ferrari, M, Ferrieres, J, Finn, JD, Forslund, A-S, Forsner, M, Frontera, G, Fujita, Y, Gaciong, Z, Galvano, F, Gao, J, Garcia-de-la-Hera, M, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Gianfagna, F, Gill, TK, Giovannelli, J, Giwercman, A, Goltzman, D, Gonzalez Gross, M, Gottrand, F, Graff-Iversen, S, Grafnetter, D, Gregor, RD, Grodzicki, T, Grosso, G, Gruden, G, Gu, D, Guallar-Castillon, P, Gudmundsson, EF, Guessous, I, Gunnlaugsdottir, J, Gutzwiller, F, Hardy, R, Hata, J, Haugsgjerd, T, Hayes, AJ, He, J, He, Y, Herrala, S, Hihtaniemi, IT, Hobbs, M, Hopman, WM, Maria Huerta, J, Huybrechts, I, Iacoviello, L, Iannone, AG, Ikeda, N, Iwasaki, M, Jamrozik, K, Janszky, I, Jarvelin, M-R, Jasienska, G, Jennings, G, Jeong, S-L, Jiang, CQ, Joffres, M, Jokelainen, JJ, Jonas, JB, Jozwiak, J, Kajantie, EO, Kauhanen, J, Keil, U, Keinanen-Kiukaanniemi, S, Kersting, M, Kiechl-Kohlendorfer, U, Kiechl, S, Kim, J, Kim, Y-Y, Klumbiene, J, Knoflach, M, Ko, S, Kolle, E, Korpelainen, R, Koskinen, S, Kouda, K, Kratzer, W, Kriemler, S, Krokstad, S, Kujala, UM, Kurjata, P, Lam, TH, Lanska, V, Lappas, G, Laugsand, LE, Lee, J, Lehtimaki, T, Li, Y, Lilly, CL, Lin, X, Lind, L, Lissner, L, Liu, J, Lopez-Garcia, E, Lorbeer, R, Eugenio Lozano, J, Luksiene, D, Lundqvist, A, Lundqvist, R, Lytsy, P, Ma, G, Machi, S, Maggi, S, Magliano, DJ, Manzato, E, Mathiesen, EB, McLachlan, S, McLean, RM, McLean, SB, Meirhaeghe, A, Meisinger, C, Metcalf, P, Mi, J, Miller, JC, Moreno, LA, Morin, SN, Mossakowska, M, Muiesan, ML, Mursu, J, Nakamura, H, Namesna, J, Nauck, M, Maria Navarrete-Munoz, E, Neal, WA, Nenko, I, Niiranen, TJ, Ning, G, Noale, M, Norie, S, Noto, D, O'Neill, T, O'Reilly, D, Oh, K, Olafsson, O, Paccaud, FM, Pajak, A, Palmieri, L, Panza, F, Parnell, WR, Peltonen, M, Peters, A, Petersmann, A, Pigeot, I, Pilotto, L, Piwonska, A, Plans-Rubio, P, Porta, M, Price, JF, Puder, JJ, Puhakka, SE, Radisauskas, R, Raitakari, O, Ramos, R, Redon, J, Rigo, F, del Cristo Rodriguez-Perez, M, Romaguera, D, Ronkainen, K, Rosengren, A, Roy, JGR, Ruidavets, J-B, Rutkowski, M, Salanave, B, Salmeron, D, Salomaa, V, Salonen, JT, Salvetti, M, Sans, S, Saramies, JL, Saum, K-U, Scheidt-Nave, C, Schienkiewitz, A, Schipf, S, Schmidt, CO, Schoettker, B, Sebert, S, Sen, A, Shaw, JE, Shibuya, K, Shin, DW, Shiri, R, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Solfrizzi, V, Sonestedt, E, Soumare, A, Staessen, JA, Stathopoulou, MG, Steene-Johannessen, J, Stehle, P, Stieber, J, Stoeckl, D, Stokwiszewski, J, Sundstrom, J, Suriyawongpaisal, P, Tamosiunas, A, Tan, EJ, Taylor, A, Tell, G, Thijs, L, Tolonen, HK, Topor-Madry, R, Jose Tormo, M, Torrent, M, Tsugane, S, Tuomainen, T-P, Tuomilehto, J, Tzourio, C, Uusitalo, HMT, Van Herck, K, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Veronesi, G, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Vollenweider, P, Voutilainen, S, Vrijheid, M, Wagner, A, Wang, M-D, Wang, Q, Wang, YX, Wannamethee, SG, Wei, W, Whincup, PH, Wiecek, A, Willeit, J, Willeit, P, Wojtyniak, B, Wong, A, Woodward, M, Wu, FC, Wu, S, Xu, H, Xu, L, Yan, W, Yang, X, Ye, X, Yoshihara, A, Zambon, S, Zhao, W, Taddei, C, Jackson, R, Zhou, B, Bixby, H, Danaei, G, Di Cesare, M, Kuulasmaa, K, Hajifathalian, K, Bentham, J, Bennett, JE, Aekplakorn, W, Cifkova, R, Dallongeville, J, DeBacquer, D, Giampaoli, S, Gudnason, V, Khang, Y-H, Laatikainen, T, Mann, J, Marques-Vidal, P, Mensah, GA, Mueller-Nurasyid, M, Ninomiya, T, Petkeviciene, J, Rodriguez-Artalejo, F, Servais, J, Soderberg, S, Stavreski, B, Wilsgaard, T, Zdrojewski, T, Zhao, D, Stevens, GA, Savin, S, Cowan, MJ, Riley, LM, Ezzati, M, Adams, RJ, Ahrens, W, Amouyel, P, Amuzu, A, Anderssen, SA, Ariansen, I, Arveiler, D, Aspelund, T, Auvinen, J, Avdicova, M, Banach, M, Bandosz, P, Banegas, JR, Barbagallo, CM, Bata, I, Baur, LA, Beaglehole, R, Bernotiene, G, Bi, Y, Bienek, A, Bjorkelund, C, Bo, S, Boehm, BO, Bonaccio, M, Bongard, V, Borchini, R, Borghs, H, Breckenkamp, J, Brenner, H, Bruno, G, Busch, MA, Cabrera de Leon, A, Capuano, V, Casanueva, FF, Casas, J-P, Caserta, CA, Censi, L, Chen, F, Chen, S, Chirlaque, M-D, Cho, B, Cho, Y, Chudek, J, Claessens, F, Clarke, J, Clays, E, Cooper, C, Costanzo, S, Cottel, D, Cowell, C, Crujeiras, AB, Cui, L, D'Arrigo, G, Dauchet, L, De Backer, G, De Bacquer, D, de Gaetano, G, De Henauw, S, De Smedt, D, Dennison, E, Deschamps, V, Di Castelnuovo, A, Dobson, AJ, Donfrancesco, C, Doering, A, Drygas, W, Du, Y, Dziankowska-Zaborszczyk, E, Eggertsen, R, Ekelund, U, Elosua, R, Eriksson, JG, Evans, A, Faeh, D, Felix-Redondo, FJ, Fernandez-Berges, D, Ferrari, M, Ferrieres, J, Finn, JD, Forslund, A-S, Forsner, M, Frontera, G, Fujita, Y, Gaciong, Z, Galvano, F, Gao, J, Garcia-de-la-Hera, M, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Gianfagna, F, Gill, TK, Giovannelli, J, Giwercman, A, Goltzman, D, Gonzalez Gross, M, Gottrand, F, Graff-Iversen, S, Grafnetter, D, Gregor, RD, Grodzicki, T, Grosso, G, Gruden, G, Gu, D, Guallar-Castillon, P, Gudmundsson, EF, Guessous, I, Gunnlaugsdottir, J, Gutzwiller, F, Hardy, R, Hata, J, Haugsgjerd, T, Hayes, AJ, He, J, He, Y, Herrala, S, Hihtaniemi, IT, Hobbs, M, Hopman, WM, Maria Huerta, J, Huybrechts, I, Iacoviello, L, Iannone, AG, Ikeda, N, Iwasaki, M, Jamrozik, K, Janszky, I, Jarvelin, M-R, Jasienska, G, Jennings, G, Jeong, S-L, Jiang, CQ, Joffres, M, Jokelainen, JJ, Jonas, JB, Jozwiak, J, Kajantie, EO, Kauhanen, J, Keil, U, Keinanen-Kiukaanniemi, S, Kersting, M, Kiechl-Kohlendorfer, U, Kiechl, S, Kim, J, Kim, Y-Y, Klumbiene, J, Knoflach, M, Ko, S, Kolle, E, Korpelainen, R, Koskinen, S, Kouda, K, Kratzer, W, Kriemler, S, Krokstad, S, Kujala, UM, Kurjata, P, Lam, TH, Lanska, V, Lappas, G, Laugsand, LE, Lee, J, Lehtimaki, T, Li, Y, Lilly, CL, Lin, X, Lind, L, Lissner, L, Liu, J, Lopez-Garcia, E, Lorbeer, R, Eugenio Lozano, J, Luksiene, D, Lundqvist, A, Lundqvist, R, Lytsy, P, Ma, G, Machi, S, Maggi, S, Magliano, DJ, Manzato, E, Mathiesen, EB, McLachlan, S, McLean, RM, McLean, SB, Meirhaeghe, A, Meisinger, C, Metcalf, P, Mi, J, Miller, JC, Moreno, LA, Morin, SN, Mossakowska, M, Muiesan, ML, Mursu, J, Nakamura, H, Namesna, J, Nauck, M, Maria Navarrete-Munoz, E, Neal, WA, Nenko, I, Niiranen, TJ, Ning, G, Noale, M, Norie, S, Noto, D, O'Neill, T, O'Reilly, D, Oh, K, Olafsson, O, Paccaud, FM, Pajak, A, Palmieri, L, Panza, F, Parnell, WR, Peltonen, M, Peters, A, Petersmann, A, Pigeot, I, Pilotto, L, Piwonska, A, Plans-Rubio, P, Porta, M, Price, JF, Puder, JJ, Puhakka, SE, Radisauskas, R, Raitakari, O, Ramos, R, Redon, J, Rigo, F, del Cristo Rodriguez-Perez, M, Romaguera, D, Ronkainen, K, Rosengren, A, Roy, JGR, Ruidavets, J-B, Rutkowski, M, Salanave, B, Salmeron, D, Salomaa, V, Salonen, JT, Salvetti, M, Sans, S, Saramies, JL, Saum, K-U, Scheidt-Nave, C, Schienkiewitz, A, Schipf, S, Schmidt, CO, Schoettker, B, Sebert, S, Sen, A, Shaw, JE, Shibuya, K, Shin, DW, Shiri, R, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Solfrizzi, V, Sonestedt, E, Soumare, A, Staessen, JA, Stathopoulou, MG, Steene-Johannessen, J, Stehle, P, Stieber, J, Stoeckl, D, Stokwiszewski, J, Sundstrom, J, Suriyawongpaisal, P, Tamosiunas, A, Tan, EJ, Taylor, A, Tell, G, Thijs, L, Tolonen, HK, Topor-Madry, R, Jose Tormo, M, Torrent, M, Tsugane, S, Tuomainen, T-P, Tuomilehto, J, Tzourio, C, Uusitalo, HMT, Van Herck, K, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Veronesi, G, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Vollenweider, P, Voutilainen, S, Vrijheid, M, Wagner, A, Wang, M-D, Wang, Q, Wang, YX, Wannamethee, SG, Wei, W, Whincup, PH, Wiecek, A, Willeit, J, Willeit, P, Wojtyniak, B, Wong, A, Woodward, M, Wu, FC, Wu, S, Xu, H, Xu, L, Yan, W, Yang, X, Ye, X, Yoshihara, A, Zambon, S, and Zhao, W
- Abstract
BACKGROUND: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. METHODS: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. RESULTS: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. CONCLUSIONS: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.
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- 2020
47. Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study
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Baumeister, S.E. Schlesinger, S. Aleksandrova, K. Jochem, C. Jenab, M. Gunter, M.J. Overvad, K. Tjønneland, A. Boutron-Ruault, M.-C. Carbonnel, F. Fournier, A. Kühn, T. Kaaks, R. Pischon, T. Boeing, H. Trichopoulou, A. Bamia, C. La Vecchia, C. Masala, G. Panico, S. Fasanelli, F. Tumino, R. Grioni, S. Bueno de Mesquita, B. Vermeulen, R. May, A.M. Borch, K.B. Oyeyemi, S.O. Ardanaz, E. Rodríguez-Barranco, M. Dolores Chirlaque López, M. Felez-Nobrega, M. Sonestedt, E. Ohlsson, B. Hemmingsson, O. Werner, M. Perez-Cornago, A. Ferrari, P. Stepien, M. Freisling, H. Tsilidis, K.K. Ward, H. Riboli, E. Weiderpass, E. Leitzmann, M.F.
- Abstract
Background & Aims: To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection). Results: In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95% CI 0.38–0.80) comparing active and inactive individuals. Regarding vigorous physical activity, for those reporting >2 hours/week compared to those with no vigorous activity, the HR for HCC was 0.50 (95% CI 0.33–0.76). Estimates were similar in sensitivity analyses for confounding. Total and vigorous physical activity were unrelated to IHBC and NGBC. In mediation analysis, waist circumference explained about 40% and body mass index 30% of the overall association of total physical activity and HCC. Conclusions: These findings suggest an inverse association between physical activity and risk of HCC, which is potentially mediated by obesity. Lay summary: In a pan-European study of 467,336 men and women, we found that physical activity is associated with a reduced risk of developing liver cancers over the next decade. This risk was independent of other liver cancer risk factors, and did not vary by age, gender, smoking status, body weight, and alcohol consumption. © 2019 European Association for the Study of the Liver
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- 2019
48. Timing of eating across ten European countries - Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study
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Huseinovic, E. Winkvist, A. Freisling, H. Slimani, N. Boeing, H. Buckland, G. Schwingshackl, L. Olsen, A. Tjonneland, A. Stepien, M. Boutron-Ruault, M.-C. Mancini, F. Artaud, F. Kühn, T. Katzke, V. Trichopoulou, A. Naska, A. Orfanos, P. Tumino, R. Masala, G. Krogh, V. Santucci De Magistris, M. Ocké, M.C. Brustad, M. Jensen, T.E. Skeie, G. Rodríguez-Barranco, M. Huerta, J.M. Ardanaz, E. Quirós, J.R. Jakszyn, P. Sonestedt, E. Ericson, U. Wennberg, M. Key, T.J. Aune, D. Riboli, E. Weiderpass, E. Bertéus Forslund, H.
- Abstract
Objective To examine timing of eating across ten European countries.Design Cross-sectional analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study using standardized 24 h diet recalls collected during 1995-2000. Eleven predefined food consumption occasions were assessed during the recall interview. We present time of consumption of meals and snacks as well as the later:earlier energy intake ratio, with earlier and later intakes defined as 06.00-14.00 and 15.00-24.00 hours, respectively. Type III tests were used to examine associations of sociodemographic, lifestyle and health variables with timing of energy intake.Setting Ten Western European countries.Subjects In total, 22 985 women and 13 035 men aged 35-74 years (n 36 020).Results A south-north gradient was observed for timing of eating, with later consumption of meals and snacks in Mediterranean countries compared with Central and Northern European countries. However, the energy load was reversed, with the later:earlier energy intake ratio ranging from 0·68 (France) to 1·39 (Norway) among women, and from 0·71 (Greece) to 1·35 (the Netherlands) among men. Among women, country, age, education, marital status, smoking, day of recall and season were all independently associated with timing of energy intake (all P
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- 2019
49. Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease: A Prospective Study of 7198 Incident Cases among 409 885 Participants in the Pan-European EPIC Cohort
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Key, T.J. Appleby, P.N. Bradbury, K.E. Sweeting, M. Wood, A. Johansson, I. Kühn, T. Steur, M. Weiderpass, E. Wennberg, M. Lund Würtz, A.M. Agudo, A. Andersson, J. Arriola, L. Boeing, H. Boer, J.M.A. Bonnet, F. Boutron-Ruault, M.-C. Cross, A.J. Ericson, U. Fagherazzi, G. Ferrari, P. Gunter, M. Huerta, J.M. Katzke, V. Khaw, K.-T. Krogh, V. La Vecchia, C. Matullo, G. Moreno-Iribas, C. Naska, A. Nilsson, L.M. Olsen, A. Overvad, K. Palli, D. Panico, S. Molina-Portillo, E. Quirós, J.R. Skeie, G. Sluijs, I. Sonestedt, E. Stepien, M. Tjønneland, A. Trichopoulou, A. Tumino, R. Tzoulaki, I. Van Der Schouw, Y.T. Verschuren, W.M.M. Di Angelantonio, E. Langenberg, C. Forouhi, N. Wareham, N. Butterworth, A. Riboli, E. Danesh, J.
- Abstract
Background: There is uncertainty about the relevance of animal foods to the pathogenesis of ischemic heart disease (IHD). We examined meat, fish, dairy products, and eggs and risk for IHD in the pan-European EPIC cohort (European Prospective Investigation Into Cancer and Nutrition). Methods: In this prospective study of 409 885 men and women in 9 European countries, diet was assessed with validated questionnaires and calibrated with 24-hour recalls. Lipids and blood pressure were measured in a subsample. During a mean of 12.6 years of follow-up, 7198 participants had a myocardial infarction or died of IHD. The relationships of animal foods with risk were examined with Cox regression with adjustment for other animal foods and relevant covariates. Results: The hazard ratio (HR) for IHD was 1.19 (95% CI, 1.06-1.33) for a 100-g/d increment in intake of red and processed meat, and this remained significant after exclusion of the first 4 years of follow-up (HR, 1.25 [95% CI, 1.09-1.42]). Risk was inversely associated with intakes of yogurt (HR, 0.93 [95% CI, 0.89-0.98] per 100-g/d increment), cheese (HR, 0.92 [95% CI, 0.86-0.98] per 30-g/d increment), and eggs (HR, 0.93 [95% CI, 0.88-0.99] per 20-g/d increment); the associations with yogurt and eggs were attenuated and nonsignificant after exclusion of the first 4 years of follow-up. Risk was not significantly associated with intakes of poultry, fish, or milk. In analyses modeling dietary substitutions, replacement of 100 kcal/d from red and processed meat with 100 kcal/d from fatty fish, yogurt, cheese, or eggs was associated with ≈20% lower risk of IHD. Consumption of red and processed meat was positively associated with serum non-high-density lipoprotein cholesterol concentration and systolic blood pressure, and consumption of cheese was inversely associated with serum non-high-density lipoprotein cholesterol. Conclusions: Risk for IHD was positively associated with consumption of red and processed meat and inversely associated with consumption of yogurt, cheese, and eggs, although the associations with yogurt and eggs may be influenced by reverse causation bias. It is not clear whether the associations with red and processed meat and cheese reflect causality, but they were consistent with the associations of these foods with plasma non-high-density lipoprotein cholesterol and for red and processed meat with systolic blood pressure, which could mediate such effects. © 2018 American Heart Association, Inc.
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- 2019
50. Association between Soft Drink Consumption and Mortality in 10 European Countries
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Mullee, A. Romaguera, D. Pearson-Stuttard, J. Viallon, V. Stepien, M. Freisling, H. Fagherazzi, G. Mancini, F.R. Boutron-Ruault, M.-C. Kühn, T. Kaaks, R. Boeing, H. Aleksandrova, K. Tjønneland, A. Halkjær, J. Overvad, K. Weiderpass, E. Skeie, G. Parr, C.L. Quirós, J.R. Agudo, A. Sánchez, M.-J. Amiano, P. Cirera, L. Ardanaz, E. Khaw, K.-T. Tong, T.Y.N. Schmidt, J.A. Trichopoulou, A. Martimianaki, G. Karakatsani, A. Palli, D. Agnoli, C. Tumino, R. Sacerdote, C. Panico, S. Bueno-De-Mesquita, B. Verschuren, W.M.M. Boer, J.M.A. Vermeulen, R. Ramne, S. Sonestedt, E. Van Guelpen, B. Holgersson, P.L. Tsilidis, K.K. Heath, A.K. Muller, D. Riboli, E. Gunter, M.J. Murphy, N.
- Abstract
Importance: Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date. Objective: To examine the association between total, sugar-sweetened, and artificially sweetened soft drink consumption and subsequent total and cause-specific mortality. Design, Setting, and Participants: This population-based cohort study involved participants (n = 451743 of the full cohort) in the European Prospective Investigation into Cancer and Nutrition (EPIC), an ongoing, large multinational cohort of people from 10 European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Norway, Spain, Sweden, and the United Kingdom), with participants recruited between January 1, 1992, and December 31, 2000. Excluded participants were those who reported cancer, heart disease, stroke, or diabetes at baseline; those with implausible dietary intake data; and those with missing soft drink consumption or follow-up information. Data analyses were performed from February 1, 2018, to October 1, 2018. Exposure: Consumption of total, sugar-sweetened, and artificially sweetened soft drinks. Main Outcomes and Measures: Total mortality and cause-specific mortality. Hazard ratios (HRs) and 95% CIs were estimated using multivariable Cox proportional hazards regression models adjusted for other mortality risk factors. Results: In total, 521 330 individuals were enrolled. Of this total, 451743 (86.7%) were included in the study, with a mean (SD) age of 50.8 (9.8) years and with 321081 women (71.1%). During a mean (range) follow-up of 16.4 (11.1 in Greece to 19.2 in France) years, 41693 deaths occurred. Higher all-cause mortality was found among participants who consumed 2 or more glasses per day (vs consumers of
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- 2019
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