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3. Are doctors using more preventive medication for cardiovascular disease? A Swedish cross-sectional study

Author

Lillqvist, Joel, Sommar, Johan N., Gustafsson, Per E., Glader, Eva-Lotta, Hamberg, Katarina, and Rolandsson, Olov

Abstract

Despite decreasing mortality from cardiovascular disease (CVD), there are persistent inequities in mortality between socioeconomic groups. Primary preventative medications reduce mortality in CVD; thus, inequitable treatments will contribute to unequal outcomes. Physicians might contribute to inequality by prescribing preventative medication for CVD to themselves in a biased manner. To determine whether primary medications for preventing CVD were prescribed inequitably between physicians and non-physicians. This retrospective study retrieved registry data on prescribed medications for all physicians in Sweden aged 45–74 years, during 2013, and for reference non-physician individuals, matched by sex, age, residence, and level of education. The outcome was any medication for preventing CVD, received at least once during 2013. Age and the sex-specific prevalence of myocardial infarction (MI) among physicians and non-physicians were used as a proxy for the need for medication. Thereafter, to limit the analysis to preventative medication, we excluded individuals that were diagnosed with CVD or diabetes. To analyse differences in medication usage between physicians and matched non-physicians, we estimated odds ratios (ORs) with conditional logistic regression and adjusted for need and household income. MI prevalences were 5.7% for men and 2.3% for women, among physicians, and 5.4% for men and 1.8% for women, among non-physicians. We included 25,105 physicians and 44,366 non-physicians. The OR for physicians receiving any CVD preventative medication, compared to non-physicians, was 1.65 (95% confidence interval 1.59–1.72). We found an inequity in prescribed preventative CVD medications, which favoured physicians over non-physicians. Groups with low socioeconomic status have lower rates of using medication that prevents cardiovascular disease, compared to groups with high socioeconomic status. Physicians are responsible for prescribing all medicines to prevent cardiovascular disease; thus, biased prescriptions could have effects on the equality of care in the population. Compared to individuals with equivalent education, physicians had higher rates of using medication that prevents cardiovascular disease. This study highlights the need for systematic population-based evaluation of CVD risk in order to promote equitable CVD outcomes.

Published
2023
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4. The urban exposome and mortality: an analysis of European administrative cohorts

Author

Samoli, Evi, primary, Stafoggia, Massimo, additional, Dimakopoulou, Konstantina, additional, Nobile, Federica, additional, Katsouyanni, Klea, additional, Vienneau, Danielle, additional, Tonne, Cathryn, additional, Olmos, Sergio, additional, Sommar, Johan N, additional, Janssen, Nicole, additional, Ibi, Dorina, additional, Vlaanderen, Jelle, additional, and Vermeulen, Roel CH, additional

Published
2022
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5. Using Distributed Lag Non-Linear Models to Estimate Exposure Lag-Response Associations between Long-Term Air Pollution Exposure and Incidence of Cardiovascular Disease

Author

Kriit, Hedi Katre, Andersson, Eva M., Carlsen, Hanne K., Andersson, Niklas, Ljungman, Petter L. S., Pershagen, Göran, Segersson, David, Eneroth, Kristina, Gidhagen, Lars, Spanne, Mårten, Molnar, Peter, Wennberg, Patrik, Rosengren, Annika, Rizzuto, Debora, Leander, Karin, Yacamán-Méndez, Diego, Magnusson, Patrik K. E., Forsberg, Bertil, Stockfelt, Leo, Sommar, Johan N., Kriit, Hedi Katre, Andersson, Eva M., Carlsen, Hanne K., Andersson, Niklas, Ljungman, Petter L. S., Pershagen, Göran, Segersson, David, Eneroth, Kristina, Gidhagen, Lars, Spanne, Mårten, Molnar, Peter, Wennberg, Patrik, Rosengren, Annika, Rizzuto, Debora, Leander, Karin, Yacamán-Méndez, Diego, Magnusson, Patrik K. E., Forsberg, Bertil, Stockfelt, Leo, and Sommar, Johan N.

Abstract

Long-term air pollution exposure increases the risk for cardiovascular disease, but little is known about the temporal relationships between exposure and health outcomes. This study aims to estimate the exposure-lag response between air pollution exposure and risk for ischemic heart disease (IHD) and stroke incidence by applying distributed lag non-linear models (DLNMs). Annual mean concentrations of particles with aerodynamic diameter less than 2.5 µm (PM2.5) and black carbon (BC) were estimated for participants in five Swedish cohorts using dispersion models. Simultaneous estimates of exposure lags 1–10 years using DLNMs were compared with separate year specific (single lag) estimates and estimates for lag 1–5- and 6–10-years using moving average exposure. The DLNM estimated no exposure lag-response between PM2.5 total, BC, and IHD. However, for PM2.5 from local sources, a 20% risk increase per 1 µg/m3 for 1-year lag was estimated. A risk increase for stroke was suggested in relation to lags 2–4-year PM2.5 and BC, and also lags 8–9-years BC. No associations were shown in single lag models. Increased risk estimates for stroke in relation to lag 1–5- and 6–10-years BC moving averages were observed. Estimates generally supported a greater contribution to increased risk from exposure windows closer in time to incident IHD and incident stroke.

Published
2022
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6. Bättre metoder att beskriva hälsovinster av minskad exponering för luftföroreningar från vägtrafik

Author

Forsberg, Bertil, Löwenhem, Boel, Sommar, Johan N, Kriit, Hedi, Strömgren, Magnus, Johansson, Christer, Forsberg, Bertil, Löwenhem, Boel, Sommar, Johan N, Kriit, Hedi, Strömgren, Magnus, and Johansson, Christer

Abstract

Trafikverket behöver bättre metoder för att beskriva och värdera hälsoeffekter av en förändrad luftföroreningsexponering från vägtrafik. I detta finns ett kontinuerligt behov av att uppdatera och förbättra kunskapsunderlaget och metodiken för att beräkna och värdera hälsoeffekter. En viktig del i arbetet är att samordna forskningsresultat och beräkningsunderlag för att harmonisera olika tillämpningar där hälsoeffekter beskrivs. I den här rapporten presenteras resultat från ett forskningsprojekt som bidrar med beräkningar av fler hälsoeffekter och en ökad harmonisering. Umeå universitet (huvudansvarig) och Miljöförvaltningen i Stockholms stad har genomfört projektet med finansiering från Trafikverket. De slutsatser och rekommendationer som uttrycks i rapporten är författarnas egna och speglar inte nödvändigtvis Trafikverkets uppfattning.

Published
2022

7. Using Distributed Lag Non-Linear Models to Estimate Exposure Lag-Response Associations between Long-Term Air Pollution Exposure and Incidence of Cardiovascular Disease

Author

Kriit, Hedi Katre, primary, Andersson, Eva M., additional, Carlsen, Hanne K., additional, Andersson, Niklas, additional, Ljungman, Petter L. S., additional, Pershagen, Göran, additional, Segersson, David, additional, Eneroth, Kristina, additional, Gidhagen, Lars, additional, Spanne, Mårten, additional, Molnar, Peter, additional, Wennberg, Patrik, additional, Rosengren, Annika, additional, Rizzuto, Debora, additional, Leander, Karin, additional, Yacamán-Méndez, Diego, additional, Magnusson, Patrik K. E., additional, Forsberg, Bertil, additional, Stockfelt, Leo, additional, and Sommar, Johan N., additional

Published
2022
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9. Modeling commuter modal shifts from car trips to cycling : Scenario construction and outcomes for Stockholm, Sweden

Author

Strömgren, Magnus, Schantz, Peter, Sommar, Johan N, Raza, Wasif, Markstedt, Anders, Forsberg, Bertil, Strömgren, Magnus, Schantz, Peter, Sommar, Johan N, Raza, Wasif, Markstedt, Anders, and Forsberg, Bertil

Abstract

This article presents the construction and outcomes of scenarios modeling commuter modal shift from car trips to cycling in the metropolitan region of Stockholm, the capital of Sweden. Building and improving upon previous studies in terms of both methodological approach and degree of spatial resolution of the modeling output, we examine scenarios where car commuters able to reach their workplace within 30 and 50 minutes of cycling shift commuting mode. Overall, car–bicycle modal shift figures were 31.6% and 48.7%, respectively. However, there were considerable geographical differences. While a substantial number of new bicycle commuters appeared in all five macro-level subdivisions of the study area, modal shift was by far the highest among car commuters living in the Inner City and its immediate surroundings., FAAP

Published
2020
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11. Passive personal air sampling of dust in a working environment : A pilot study

Author

Shirdel, Mariam, Bergdahl A., Ingvar, Andersson, Britt M., Wingfors, Håkan, Sommar, Johan N., Liljelind, Ingrid E., Shirdel, Mariam, Bergdahl A., Ingvar, Andersson, Britt M., Wingfors, Håkan, Sommar, Johan N., and Liljelind, Ingrid E.

Abstract

The aim of this study was to make a preliminary evaluation of the University of North Carolina passive aerosol sampler (UNC sampler) for personal air sampling of particles. Nine personal air samplings of respirable fraction were conducted in an open-pit mine, with pairwise UNC samplers and a respirable cyclone mounted on the chest of workers. UNC samples were analyzed with scanning electron microscopy (SEM) and to some extent energy dispersive X-ray spectroscopy (EDS). Respirable cyclone filter samples were weighed. Correlations and particle elemental compositions were described. Microscopic imaging of the collection surface showed that the particles were heterogeneously deposited across the surface of the UNC sampler. Collected particles were shaped as gravel particles and the resulting particle size distribution in air showed a peak at ca. 3 µm aerodynamic diameter, similarly to what has previously been reported from the same mine. The elemental composition indicated mineral origin. All correlations between the airborne mass concentrations from UNC samplers and respirable cyclones (Pearson = 0.54 and Spearman = 0.43) and between pairs of parallel UNC samplers (Pearson = 0.55 and Spearman = 0.67) were weak. The UNC sampler mass concentrations were approximately 30 times higher than those measured with the respirable cyclone. In conclusion, the UNC sampler, when used for personal sampling in a mine, provides a reasonable particle size distribution and the deposited particles appeared to be of mineral origin and not from textile or skin but the approximately 30-fold overestimation of mass concentrations when comparing with respirable cyclone sampling indicates that further improvements are necessary. Positioning of the sampler may be critical and moving the UNC sampler from the chest to e.g. the top of a helmet might be an improvement. Grounding of the sampler in order to avoid static electricity might also be useful. The UNC sampler should continue to be researched

Published
2019
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12. Long-term Exposure to Ambient Air Pollution and Incidence of Brain Tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Author

Andersen, Zorana J., Pedersen, Marie, Weinmayr, Gudrun, Stafoggia, Massimo, Galassi, Claudia, Jørgensen, Jeanette T, Sommar, Johan N., Forsberg, Bertil, Olsson, David, Oftedal, Bente, Aasvang, Gunn Marit, Schwarze, Per E., Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Östenson, Claes Göran, Fratiglioni, Laura, Eriksen, Kirsten T., Poulsen, Aslak Harbo, Tjønneland, Anne, Vaclavik Bräuner, Elvira, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Vermeulen, Roel, Sokhi, Ranjeet S., Keuken, Menno, de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, Raaschou-Nielsen, Ole, Andersen, Zorana J., Pedersen, Marie, Weinmayr, Gudrun, Stafoggia, Massimo, Galassi, Claudia, Jørgensen, Jeanette T, Sommar, Johan N., Forsberg, Bertil, Olsson, David, Oftedal, Bente, Aasvang, Gunn Marit, Schwarze, Per E., Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Östenson, Claes Göran, Fratiglioni, Laura, Eriksen, Kirsten T., Poulsen, Aslak Harbo, Tjønneland, Anne, Vaclavik Bräuner, Elvira, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Vermeulen, Roel, Sokhi, Ranjeet S., Keuken, Menno, de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2018

13. Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts

Author

Pedersen, Marie, Stafoggia, Massimo, Weinmayr, Gudrun, Andersen, Zorana J., Galassi, Claudia, Sommar, Johan N., Forsberg, Bertil, Olsson, David, Oftedal, Bente, Krog, Norun H, Aamodt, Geir, Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Pedersen, Nancy L., Östenson, Claes Göran, Fratiglioni, Laura, Sørensen, Mette, Eriksen, Kirsten T., Tjønneland, Anne, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Eeftens, Marloes, Plusquin, Michelle, Key, Timothy J., Jaensch, Andrea, Nagel, Gabriele, Concin, Hans, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Ranzi, Andrea, Cesaroni, Giulia, Forastiere, Francesco, Tamayo, Ibon, Amiano, Pilar, Dorronsoro, Miren, Stayner, Leslie T, Kogevinas, Manolis, Nieuwenhuijsen, Mark J, Sokhi, Ranjeet S., de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Brunekreef, Bert, Hoek, Gerard, Raaschou-Nielsen, Ole, Pedersen, Marie, Stafoggia, Massimo, Weinmayr, Gudrun, Andersen, Zorana J., Galassi, Claudia, Sommar, Johan N., Forsberg, Bertil, Olsson, David, Oftedal, Bente, Krog, Norun H, Aamodt, Geir, Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Pedersen, Nancy L., Östenson, Claes Göran, Fratiglioni, Laura, Sørensen, Mette, Eriksen, Kirsten T., Tjønneland, Anne, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Eeftens, Marloes, Plusquin, Michelle, Key, Timothy J., Jaensch, Andrea, Nagel, Gabriele, Concin, Hans, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Ranzi, Andrea, Cesaroni, Giulia, Forastiere, Francesco, Tamayo, Ibon, Amiano, Pilar, Dorronsoro, Miren, Stayner, Leslie T, Kogevinas, Manolis, Nieuwenhuijsen, Mark J, Sokhi, Ranjeet S., de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2018

14. Long-term Exposure to Ambient Air Pollution and Incidence of Brain Tumor:the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Author

Andersen, Zorana J, Pedersen, Marie, Weinmayr, Gudrun, Stafoggia, Massimo, Galassi, Claudia, Jørgensen, Jeanette T, Sommar, Johan N, Forsberg, Bertil, Olsson, David, Oftedal, Bente, Aasvang, Gunn Marit, Schwarze, Per, Pyko, Andrei, Pershagen, Göran, Korek, Michal, De Faire, Ulf, Östenson, Claes-Göran, Fratiglioni, Laura, Eriksen, Kirsten T, Poulsen, Aslak H, Tjønneland, Anne, Vaclavik Bräuner, Elvira, Peeters, Petra H, Bueno-de-Mesquita, Bas, Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Vermeulen, Roel, Sokhi, Ranjeet, Keuken, Menno, de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, Raaschou-Nielsen, Ole, Andersen, Zorana J, Pedersen, Marie, Weinmayr, Gudrun, Stafoggia, Massimo, Galassi, Claudia, Jørgensen, Jeanette T, Sommar, Johan N, Forsberg, Bertil, Olsson, David, Oftedal, Bente, Aasvang, Gunn Marit, Schwarze, Per, Pyko, Andrei, Pershagen, Göran, Korek, Michal, De Faire, Ulf, Östenson, Claes-Göran, Fratiglioni, Laura, Eriksen, Kirsten T, Poulsen, Aslak H, Tjønneland, Anne, Vaclavik Bräuner, Elvira, Peeters, Petra H, Bueno-de-Mesquita, Bas, Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Vermeulen, Roel, Sokhi, Ranjeet, Keuken, Menno, de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2018

15. Improving the UNC passive aerosol sampler model based on comparison with commonly used aerosol sampling methods

Author

Shirdel, Mariam, Andersson, Britt M., Bergdahl, Ingvar, Sommar, Johan N., Wingfors, Håkan, Liljelind, Ingrid E., Shirdel, Mariam, Andersson, Britt M., Bergdahl, Ingvar, Sommar, Johan N., Wingfors, Håkan, and Liljelind, Ingrid E.

Abstract

Objectives: In an occupational environment, passive sampling could be an alternative to active sampling with pumps for sampling of dust. One passive sampler is the University of North Carolina passive aerosol sampler (UNC sampler). It is often analysed by microscopic imaging. Promising results have been shown for particles above 2.5 µm, but indicate large underestimations for PM2.5. The aim of this study was to evaluate, and possibly improve, the UNC sampler for stationary sampling in a working environment. Methods: Sampling was carried out at 8-h intervals during 24 h in four locations in an open pit mine with UNC samplers, respirable cyclones, PM10 and PM2.5 impactors, and an aerodynamic particle sizer (APS). The wind was minimal. For quantification, two modifications of the UNC sampler analysis model, UNC sampler with hybrid model and UNC sampler with area factor, were compared with the original one, UNC sampler with mesh factor derived from wind tunnel experiments. The effect of increased resolution for the microscopic imaging was examined. Results: Use of the area factor and a higher resolution eliminated the underestimation for PM10 and PM2.5. The model with area factor had the overall lowest deviation versus the impactor and the cyclone. The intraclass correlation (ICC) showed that the UNC sampler had a higher precision and better ability to distinguish between different exposure levels compared to the cyclone (ICC: 0.51 versus 0.24), but lower precision compared to the impactor (PM10: 0.79 versus 0.99; PM2.5: 0.30 versus 0.45). The particle size distributions as calculated from the different UNC sampler analysis models were visually compared with the distributions determined by APS. The distributions were obviously different when the UNC sampler with mesh factor was used but came to a reasonable agreement when the area factor was used. Conclusions: High resolution combined with a factor based on area only, results in no underestimation of small particles com

Published
2018
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16. Choosing the number of images and image position when analysing the UNC Passive Aerosol Sampler for occupational exposure assessment

Author

Shirdel, Mariam, Sommar, Johan N., Andersson, Britt M., Bergdahl, Ingvar A., Wingfors, H, Liljelind, Ingrid E., Shirdel, Mariam, Sommar, Johan N., Andersson, Britt M., Bergdahl, Ingvar A., Wingfors, H, and Liljelind, Ingrid E.

Abstract

The University of North Carolina passive aerosol sampler (UNC sampler) could be an alternative when measuring occupational dust exposure, but the time required for microscopic imaging of the sampler needs to be reduced to make it more attractive. The aims of this study were to 1) characterise the effect on precision when reducing imaging, in order to shorten analysis time and 2) assess if the position of the images makes a difference. Eighty-eight samplers were deployed in different locations of an open pit mine. Sixty images were captured for each UNC sampler, covering 51% of its collection surface, using scanning electron microscopy. Bootstrapped samples were generated with different image combinations, to assess the within-sampler coefficient of variation (CVws) for different numbers of images. In addition, the particle concentration relative to the distance from the centre of the sampler was studied. Reducing the number of images collected from the UNC sampler led to up to 8.3% CVws for ten images when calculating respirable fraction. As the overall CV has previously been assessed to 36%, the additional contribution becomes minimal, increasing the overall CV to 37%. The mean concentrations of the images were modestly related to distance from the centre of the sampler. The CVws changed from 8.26% to 8.13% for ten images when applying rules for the image collection based on distance. Thus, the benefit of these rules on the precision is small and the images can therefore be chosen at random. In conclusion, reducing the number of images analysed from 60 to 10, corresponding to a reduction of the imaged sampling area from 51% to 8.5%, results in a negligible loss in precision for respirable fraction dust measurements in occupational environments.

Published
2018
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17. Long-term Exposure to Ambient Air Pollution and Incidence of Brain Tumor : the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Author

Andersen, Zorana Jovanovic, Pedersen, Marie, Weinmayr, Gudrun, Stafoggia, Massimo, Galassi, Claudia, Jørgensen, Jeanette T., Sommar, Johan N, Forsberg, Bertil, Olsson, David, Oftedal, Bente, Aasvang, Gunn Marit, Schwarze, Per E., Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Östenson, Claes Göran, Fratiglioni, Laura, Eriksen, Kirsten Thorup, Poulsen, Aslak H, Tjønneland, Anne, Vaclavik Bräuner, Elvira, Peeters, Petra H, Bueno-de-Mesquita, Bas, Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Vermeulen, Roel, Sokhi, Ranjeet S., Keuken, Menno, De Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, Raaschou-Nielsen, Ole, Andersen, Zorana Jovanovic, Pedersen, Marie, Weinmayr, Gudrun, Stafoggia, Massimo, Galassi, Claudia, Jørgensen, Jeanette T., Sommar, Johan N, Forsberg, Bertil, Olsson, David, Oftedal, Bente, Aasvang, Gunn Marit, Schwarze, Per E., Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Östenson, Claes Göran, Fratiglioni, Laura, Eriksen, Kirsten Thorup, Poulsen, Aslak H, Tjønneland, Anne, Vaclavik Bräuner, Elvira, Peeters, Petra H, Bueno-de-Mesquita, Bas, Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Vermeulen, Roel, Sokhi, Ranjeet S., Keuken, Menno, De Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2018

18. Long-term Exposure to Ambient Air Pollution and Incidence of Brain Tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Author

dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), One Health Chemisch, dIRAS RA-I&I RA, Andersen, Zorana J., Pedersen, Marie, Weinmayr, Gudrun, Stafoggia, Massimo, Galassi, Claudia, Jørgensen, Jeanette T, Sommar, Johan N., Forsberg, Bertil, Olsson, David, Oftedal, Bente, Aasvang, Gunn Marit, Schwarze, Per E., Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Östenson, Claes Göran, Fratiglioni, Laura, Eriksen, Kirsten T., Poulsen, Aslak Harbo, Tjønneland, Anne, Vaclavik Bräuner, Elvira, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Vermeulen, Roel, Sokhi, Ranjeet S., Keuken, Menno, de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, Raaschou-Nielsen, Ole, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), One Health Chemisch, dIRAS RA-I&I RA, Andersen, Zorana J., Pedersen, Marie, Weinmayr, Gudrun, Stafoggia, Massimo, Galassi, Claudia, Jørgensen, Jeanette T, Sommar, Johan N., Forsberg, Bertil, Olsson, David, Oftedal, Bente, Aasvang, Gunn Marit, Schwarze, Per E., Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Östenson, Claes Göran, Fratiglioni, Laura, Eriksen, Kirsten T., Poulsen, Aslak Harbo, Tjønneland, Anne, Vaclavik Bräuner, Elvira, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Vermeulen, Roel, Sokhi, Ranjeet S., Keuken, Menno, de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2018

19. Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts

Author

dIRAS RA-2, One Health Chemisch, dIRAS RA-I&I RA, LS IRAS EEPI ME (Milieu epidemiologie), Pedersen, Marie, Stafoggia, Massimo, Weinmayr, Gudrun, Andersen, Zorana J., Galassi, Claudia, Sommar, Johan N., Forsberg, Bertil, Olsson, David, Oftedal, Bente, Krog, Norun H, Aamodt, Geir, Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Pedersen, Nancy L., Östenson, Claes Göran, Fratiglioni, Laura, Sørensen, Mette, Eriksen, Kirsten T., Tjønneland, Anne, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Eeftens, Marloes, Plusquin, Michelle, Key, Timothy J., Jaensch, Andrea, Nagel, Gabriele, Concin, Hans, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Ranzi, Andrea, Cesaroni, Giulia, Forastiere, Francesco, Tamayo, Ibon, Amiano, Pilar, Dorronsoro, Miren, Stayner, Leslie T, Kogevinas, Manolis, Nieuwenhuijsen, Mark J, Sokhi, Ranjeet S., de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Brunekreef, Bert, Hoek, Gerard, Raaschou-Nielsen, Ole, dIRAS RA-2, One Health Chemisch, dIRAS RA-I&I RA, LS IRAS EEPI ME (Milieu epidemiologie), Pedersen, Marie, Stafoggia, Massimo, Weinmayr, Gudrun, Andersen, Zorana J., Galassi, Claudia, Sommar, Johan N., Forsberg, Bertil, Olsson, David, Oftedal, Bente, Krog, Norun H, Aamodt, Geir, Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Pedersen, Nancy L., Östenson, Claes Göran, Fratiglioni, Laura, Sørensen, Mette, Eriksen, Kirsten T., Tjønneland, Anne, Peeters, Petra H., Bueno-de-Mesquita, H. Bas, Vermeulen, Roel, Eeftens, Marloes, Plusquin, Michelle, Key, Timothy J., Jaensch, Andrea, Nagel, Gabriele, Concin, Hans, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Ranzi, Andrea, Cesaroni, Giulia, Forastiere, Francesco, Tamayo, Ibon, Amiano, Pilar, Dorronsoro, Miren, Stayner, Leslie T, Kogevinas, Manolis, Nieuwenhuijsen, Mark J, Sokhi, Ranjeet S., de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2018

20. Long-term Exposure to Ambient Air Pollution and Incidence of Brain Tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Author

Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, MS MDL 1, Epi Infectieziekten Team 3, Circulatory Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Andersen, Zorana Jovanovic, Pedersen, Marie, Weinmayr, Gudrun, Stafoggia, Massimo, Galassi, Claudia, Jørgensen, Jeanette T., Sommar, Johan N, Forsberg, Bertil, Olsson, David, Oftedal, Bente, Aasvang, Gunn Marit, Schwarze, Per E., Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Östenson, Claes Göran, Fratiglioni, Laura, Eriksen, Kirsten Thorup, Poulsen, Aslak H, Tjønneland, Anne, Vaclavik Bräuner, Elvira, Peeters, Petra H, Bueno-de-Mesquita, Bas, Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Vermeulen, Roel, Sokhi, Ranjeet S., Keuken, Menno, De Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, Raaschou-Nielsen, Ole, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, MS MDL 1, Epi Infectieziekten Team 3, Circulatory Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Andersen, Zorana Jovanovic, Pedersen, Marie, Weinmayr, Gudrun, Stafoggia, Massimo, Galassi, Claudia, Jørgensen, Jeanette T., Sommar, Johan N, Forsberg, Bertil, Olsson, David, Oftedal, Bente, Aasvang, Gunn Marit, Schwarze, Per E., Pyko, Andrei, Pershagen, Göran, Korek, Michal, de Faire, Ulf, Östenson, Claes Göran, Fratiglioni, Laura, Eriksen, Kirsten Thorup, Poulsen, Aslak H, Tjønneland, Anne, Vaclavik Bräuner, Elvira, Peeters, Petra H, Bueno-de-Mesquita, Bas, Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Vermeulen, Roel, Sokhi, Ranjeet S., Keuken, Menno, De Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Published
2018

22. Long-term exposure to ambient air pollution and incidence of brain tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Author

Andersen, Zorana J, primary, Pedersen, Marie, additional, Weinmayr, Gudrun, additional, Stafoggia, Massimo, additional, Galassi, Claudia, additional, Jørgensen, Jeanette T, additional, Sommar, Johan N, additional, Forsberg, Bertil, additional, Olsson, David, additional, Oftedal, Bente, additional, Aasvang, Gunn Marit, additional, Schwarze, Per, additional, Pyko, Andrei, additional, Pershagen, Göran, additional, Korek, Michal, additional, Faire, Ulf De, additional, Östenson, Claes-Göran, additional, Fratiglioni, Laura, additional, Eriksen, Kirsten T, additional, Poulsen, Aslak H, additional, Tjønneland, Anne, additional, Bräuner, Elvira Vaclavik, additional, Peeters, Petra H, additional, Bueno-de-Mesquita, Bas, additional, Jaensch, Andrea, additional, Nagel, Gabriele, additional, Lang, Alois, additional, Wang, Meng, additional, Tsai, Ming-Yi, additional, Grioni, Sara, additional, Marcon, Alessandro, additional, Krogh, Vittorio, additional, Ricceri, Fulvio, additional, Sacerdote, Carlotta, additional, Migliore, Enrica, additional, Vermeulen, Roel, additional, Sokhi, Ranjeet, additional, Keuken, Menno, additional, de Hoogh, Kees, additional, Beelen, Rob, additional, Vineis, Paolo, additional, Cesaroni, Giulia, additional, Brunekreef, Bert, additional, Hoek, Gerard, additional, and Raaschou-Nielsen, Ole, additional

Published
2017
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24. A pilot study : the UNC passive aerosol sampler in a working environment

Author

Shirdel, Mariam, Wingfors, Håkan, Andersson, Britt M., Sommar, Johan N., Bergdahl, Ingvar A., Liljelind, Ingrid E., Shirdel, Mariam, Wingfors, Håkan, Andersson, Britt M., Sommar, Johan N., Bergdahl, Ingvar A., and Liljelind, Ingrid E.

Abstract

Objectives: Dust is generally sampled on a filter using air pumps, but passive sampling could be a cost-effective alternative. One promising passive sampler is the University of North Carolina passive aerosol sampler (UNC sampler). The aim of this study is to characterize and compare the UNC sampler’s performance with PM10 and PM2.5 impactors in a working environment. Methods: Area sampling was carried out at different mining locations using UNC samplers in parallel with PM2.5 and PM10 impactors. Two different collection surfaces, polycarbonate (PC) and carbon tabs (CT), were employed for the UNC sampling. Sampling was carried out for 4–25 hours. Results: The UNC samplers underestimated the concentrations compared to PM10 and PM2.5 impactor data. At the location with the highest aerosol concentration, the time-averaged mean of PC showed 24% and CT 35% of the impactor result for PM2.5. For PM10, it was 39% with PC and 58% with CT. Sample blank values differed between PC and CT. For PM2.5, PC blank values were ~7 times higher than those of CT, but only 1.8 times higher for PM10. The blank variations were larger for PC than for CT. Conclusions: Particle mass concentrations appear to be underestimated by the UNC sampler compared to impactors, more so for PM2.5 than for PM10. CT may be preferred as a collection surface because the blank values were lower and less variable than for PC. Future validations in the working environment should include respirable dust sampling.

Published
2017
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25. Long-term Exposure to Ambient Air Pollution and Incidence of Brain Tumor in 12 European Cohorts: the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Author

Andersen*, Zorana Jovanovic, primary, Pedersen, Marie, additional, Weinmayr, Gudrun, additional, Galassi, Claudia, additional, Stafoggia, Massimo, additional, Sommar, Johan N, additional, Oftedal, Bente, additional, Jaensch, Andrea, additional, Pyko, Andrei, additional, Ricceri, Fulvio, additional, Grioni, Sara, additional, Hoek, Gerard, additional, and Raschou-Nielsen, Ole, additional

Published
2016
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26. Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Author

Fuks, Kateryna B., Weinmayr, Gudrun, Foraster, Maria, Dratva, Julia, Hampel, Regina, Houthuijs, Danny, Oftedal, Bente, Oudin, Anna, Panasevich, Sviatlana, Penell, Johanna, Sommar, Johan N., Sorensen, Mette, Tiittanen, Pekka, Wolf, Kathrin, Xun, Wei W., Aguilera, Inmaculada, Basagana, Xavier, Beelen, Rob, Bots, Michiel L., Brunekreef, Bert, Bueno-de-Mesquita, H. Bas, Caracciolo, Barbara, Cirach, Marta, de Faire, Ulf, de Nazelle, Audrey, Eeftens, Marloes, Elosua, Roberto, Erbel, Raimund, Forsberg, Bertil, Fratiglioni, Laura, Gaspoz, Jean-Michel, Hilding, Agneta, Jula, Antti, Korek, Michal, Kraemer, Ursula, Kuenzli, Nino, Lanki, Timo, Leander, Karin, Magnusson, Patrik K. E., Marrugat, Jaume, Nieuwenhuijsen, Mark J., Oestenson, Claes-Goeran, Pedersen, Nancy L., Pershagen, Goeran, Phuleria, Harish C., Probst-Hensch, Nicole M., Raaschou-Nielsen, Ole, Schaffner, Emmanuel, Schikowski, Tamara, Schindler, Christian, Schwarze, Per E., Sogaard, Anne J., Sugiri, Dorothea, Swart, Wim J. R., Tsai, Ming-Yi, Turunen, Anu W., Vineis, Paolo, Peters, Annette, Hoffmann, Barbara, Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Wolf, Kathrin, Gaspoz, Jean-Michel, Hoffmann, Barbara, Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, and IRAS RATIA2

Subjects
Male, Health, Toxicology and Mutagenesis, air pollution, 05 Environmental Sciences, Medizin, Air pollution, VDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803, Review, 030204 cardiovascular system & hematology, 010501 environmental sciences, medicine.disease_cause, Bioinformatics, NO2, Toxicology, 01 natural sciences, 0302 clinical medicine, Risk Factors, USE REGRESSION-MODELS, Medicine, Nitrogen oxides, land use regression (LUR) model, Public, Environmental & Occupational Health, Vehicle Emissions, RISK, education.field_of_study, Air Pollutants, 11 Medical And Health Sciences, ASSOCIATION, 3. Good health, Europe, Noise, Transportation, Female, Nitrogen Oxides, VDP::Midical sciences: 700::Health sciences: 800::Epidemiology, medical and dental statistics: 803, Life Sciences & Biomedicine, PROJECT, Population, Diastole, Environmental Sciences & Ecology, NOx, Land use regression, ESCAPE, 03 medical and health sciences, Arbetsmedicin och miljömedicin, Environmental health, Air Pollution, Humans, PARTICLES, Arterial Pressure, CORONARY-HEART-DISEASE, education, Antihypertensive Agents, METAANALYSIS, 0105 earth and related environmental sciences, ddc:613, Science & Technology, HYPERTENSION, business.industry, Public Health, Environmental and Occupational Health, European population, Odds ratio, Occupational Health and Environmental Health, Environmental Exposure, Blood pressure, Cross-Sectional Studies, ATHEROSCLEROSIS, 13. Climate action, Particulate Matter, business, PRIMARY PREVENTION, Environmental Sciences
Abstract

Background: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific. Objectives: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hypertension in European populations. Methods: We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hypertension was defined as ≥ 140 mmHg systolic BP, or ≥ 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis. Results: In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles × m/day, respectively]. The estimated odds ratio (OR) for prevalent hypertension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles × m/day. Modeled air pollutants and BP were not clearly associated. Conclusions: In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hypertension. The relationship of modeled air pollutants with BP was inconsistent. Citation: Fuks KB, Weinmayr G, Foraster M, Dratva J, Hampel R, Houthuijs D, Oftedal B, Oudin A, Panasevich S, Penell J, Sommar JN, Sørensen M, Tittanen P, Wolf K, Xun WW, Aguilera I, Basagaña X, Beelen R, Bots ML, Brunekreef B, Bueno-de-Mesquita HB, Caracciolo B, Cirach M, de Faire U, de Nazelle A, Eeftens M, Elosua R, Erbel R, Forsberg B, Fratiglioni L, Gaspoz JM, Hilding A, Jula A, Korek M, Krämer U, Künzli N, Lanki T, Leander K, Magnusson PK, Marrugat J, Nieuwenhuijsen MJ, Östenson CG, Pedersen NL, Pershagen G, Phuleria HC, Probst-Hensch NM, Raaschou-Nielsen O, Schaffner E, Schikowski T, Schindler C, Schwarze PE, Søgaard AJ, Sugiri D, Swart WJ, Tsai MY, Turunen AW, Vineis P, Peters A, Hoffmann B. 2014. Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Environ Health Perspect 122:896–905; http://dx.doi.org/10.1289/ehp.1307725

Published
2014

27. Arterial Blood Pressure and Long-Term Exposure to Traffic-Related Air Pollution: An Analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Author

Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Fuks, Kateryna B., Weinmayr, Gudrun, Foraster, Maria, Dratva, Julia, Hampel, Regina, Houthuijs, Danny, Oftedal, Bente, Oudin, Anna, Panasevich, Sviatlana, Penell, Johanna, Sommar, Johan N., Sorensen, Mette, Tiittanen, Pekka, Wolf, Kathrin, Xun, Wei W., Aguilera, Inmaculada, Basagana, Xavier, Beelen, Rob, Bots, Michiel L., Brunekreef, Bert, Bueno-de-Mesquita, H. Bas, Caracciolo, Barbara, Cirach, Marta, de Faire, Ulf, de Nazelle, Audrey, Eeftens, Marloes, Elosua, Roberto, Erbel, Raimund, Forsberg, Bertil, Fratiglioni, Laura, Gaspoz, Jean-Michel, Hilding, Agneta, Jula, Antti, Korek, Michal, Kraemer, Ursula, Kuenzli, Nino, Lanki, Timo, Leander, Karin, Magnusson, Patrik K. E., Marrugat, Jaume, Nieuwenhuijsen, Mark J., Oestenson, Claes-Goeran, Pedersen, Nancy L., Pershagen, Goeran, Phuleria, Harish C., Probst-Hensch, Nicole M., Raaschou-Nielsen, Ole, Schaffner, Emmanuel, Schikowski, Tamara, Schindler, Christian, Schwarze, Per E., Sogaard, Anne J., Sugiri, Dorothea, Swart, Wim J. R., Tsai, Ming-Yi, Turunen, Anu W., Vineis, Paolo, Peters, Annette, Hoffmann, Barbara, Dep IRAS, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Fuks, Kateryna B., Weinmayr, Gudrun, Foraster, Maria, Dratva, Julia, Hampel, Regina, Houthuijs, Danny, Oftedal, Bente, Oudin, Anna, Panasevich, Sviatlana, Penell, Johanna, Sommar, Johan N., Sorensen, Mette, Tiittanen, Pekka, Wolf, Kathrin, Xun, Wei W., Aguilera, Inmaculada, Basagana, Xavier, Beelen, Rob, Bots, Michiel L., Brunekreef, Bert, Bueno-de-Mesquita, H. Bas, Caracciolo, Barbara, Cirach, Marta, de Faire, Ulf, de Nazelle, Audrey, Eeftens, Marloes, Elosua, Roberto, Erbel, Raimund, Forsberg, Bertil, Fratiglioni, Laura, Gaspoz, Jean-Michel, Hilding, Agneta, Jula, Antti, Korek, Michal, Kraemer, Ursula, Kuenzli, Nino, Lanki, Timo, Leander, Karin, Magnusson, Patrik K. E., Marrugat, Jaume, Nieuwenhuijsen, Mark J., Oestenson, Claes-Goeran, Pedersen, Nancy L., Pershagen, Goeran, Phuleria, Harish C., Probst-Hensch, Nicole M., Raaschou-Nielsen, Ole, Schaffner, Emmanuel, Schikowski, Tamara, Schindler, Christian, Schwarze, Per E., Sogaard, Anne J., Sugiri, Dorothea, Swart, Wim J. R., Tsai, Ming-Yi, Turunen, Anu W., Vineis, Paolo, Peters, Annette, and Hoffmann, Barbara

Published
2014

28. Long-term exposure to ambient air pollution and incidence of brain tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Author

Andersen, Zorana J., Pedersen, Marie, Weinmayr, Gudrun, Stafoggia, Massimo, Galassi, Claudia, Jørgensen, Jeanette T., Sommar, Johan N., Forsberg, Bertil, Olsson, David, Oftedal, Bente, Aasvang, Gunn Marit, Schwarze, Per, Pyko, Andrei, Pershagen, Göran, Korek, Michal, Faire, Ulf De, Östenson, Claes-Göran, Fratiglioni, Laura, Eriksen, Kirsten T., Poulsen, Aslak H., Tjønneland, Anne, Bräuner, Elvira Vaclavik, Peeters, Petra H., Bueno-de-Mesquita, Bas, Jaensch, Andrea, Nagel, Gabriele, Lang, Alois, Wang, Meng, Tsai, Ming-Yi, Grioni, Sara, Marcon, Alessandro, Krogh, Vittorio, Ricceri, Fulvio, Sacerdote, Carlotta, Migliore, Enrica, Vermeulen, Roel, Sokhi, Ranjeet, Keuken, Menno, de Hoogh, Kees, Beelen, Rob, Vineis, Paolo, Cesaroni, Giulia, Brunekreef, Bert, Hoek, Gerard, and Raaschou-Nielsen, Ole

Subjects
13. Climate action, 3. Good health

29. Arterial blood pressure and long-term exposure to traffic-related air pollution : an analysis in the European study of cohorts for air pollution effects (ESCAPE)

Author

Fuks, Kateryna B., Weinmayr, Gudrun, Foraster, Maria, Dratva, Julia, Hampel, Regina, Houthuijs, Danny, Oftedal, Bente, Oudin, Anna, Panasevich, Sviatlana, Penell, Johanna, Sommar, Johan N., Sørensen, Mette, Tiittanen, Pekka, Wolf, Kathrin, Xun, Wei W., Aguilera, Inmaculada, Basagaña, Xavier, Beelen, Rob, Bots, Michiel L., Brunekreef, Bert, Bueno-de-Mesquita, H. Bas, Caracciolo, Barbara, Cirach, Marta, de Faire, Ulf, de Nazelle, Audrey, Eeftens, Marloes, Elosua, Roberto, Erbel, Raimund, Forsberg, Bertil, Fratiglioni, Laura, Gaspoz, Jean-Michel, Hilding, Agneta, Jula, Antti, Korek, Michal, Krämer, Ursula, Künzli, Nino, Lanki, Timo, Leander, Karin, Magnusson, Patrik K. E., Marrugat, Jaume, Nieuwenhuijsen, Mark J., Ostenson, Claes-Göran, Pedersen, Nancy L., Pershagen, Göran, Phuleria, Harish C., Probst-Hensch, Nicole M., Raaschou-Nielsen, Ole, Schaffner, Emmanuel, Schikowski, Tamara, Schindler, Christian, Schwarze, Per E., Søgaard, Anne J., Sugiri, Dorothea, Swart, Wim J. R., Tsai, Ming-Yi, Turunen, Anu W., Vineis, Paolo, Peters, Annette, and Hoffmann, Barbara

Subjects
13. Climate action, 3. Good health

32. Long-term exposure to ambient air pollution and incidence of brain tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE).

Author

Andersen ZJ, Pedersen M, Weinmayr G, Stafoggia M, Galassi C, Jørgensen JT, Sommar JN, Forsberg B, Olsson D, Oftedal B, Aasvang GM, Schwarze P, Pyko A, Pershagen G, Korek M, Faire U, Östenson CG, Fratiglioni L, Eriksen KT, Poulsen AH, Tjønneland A, Bräuner EV, Peeters PH, Bueno-de-Mesquita B, Jaensch A, Nagel G, Lang A, Wang M, Tsai MY, Grioni S, Marcon A, Krogh V, Ricceri F, Sacerdote C, Migliore E, Vermeulen R, Sokhi R, Keuken M, de Hoogh K, Beelen R, Vineis P, Cesaroni G, Brunekreef B, Hoek G, and Raaschou-Nielsen O

Subjects
Adult, Brain Neoplasms pathology, Cohort Studies, Europe epidemiology, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Prognosis, Risk Factors, Air Pollution adverse effects, Brain Neoplasms epidemiology, Brain Neoplasms etiology, Environmental Exposure adverse effects, Particulate Matter adverse effects
Abstract

Background: Epidemiological evidence on the association between ambient air pollution and brain tumor risk is sparse and inconsistent., Methods: In 12 cohorts from 6 European countries, individual estimates of annual mean air pollution levels at the baseline residence were estimated by standardized land-use regression models developed within the ESCAPE and TRANSPHORM projects: particulate matter (PM) ≤2.5, ≤10, and 2.5-10 μm in diameter (PM2.5, PM10, and PMcoarse), PM2.5 absorbance, nitrogen oxides (NO2 and NOx) and elemental composition of PM. We estimated cohort-specific associations of air pollutant concentrations and traffic intensity with total, malignant, and nonmalignant brain tumor, in separate Cox regression models, adjusting for risk factors, and pooled cohort-specific estimates using random-effects meta-analyses., Results: Of 282194 subjects from 12 cohorts, 466 developed malignant brain tumors during 12 years of follow-up. Six of the cohorts also had data on nonmalignant brain tumor, where among 106786 subjects, 366 developed brain tumor: 176 nonmalignant and 190 malignant. We found a positive, statistically nonsignificant association between malignant brain tumor and PM2.5 absorbance (hazard ratio and 95% CI: 1.67; 0.89-3.14 per 10-5/m3), and weak positive or null associations with the other pollutants. Hazard ratio for PM2.5 absorbance (1.01; 0.38-2.71 per 10-5/m3) and all other pollutants were lower for nonmalignant than for malignant brain tumors., Conclusion: We found suggestive evidence of an association between long-term exposure to PM2.5 absorbance indicating traffic-related air pollution and malignant brain tumors, and no association with overall or nonmalignant brain tumors., (© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.)

Published
2018
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