1. In vitro evaluation of sustained ciprofloxacin release from κ-carrageenan-crosslinked chitosan/hydroxyapatite hydrogel nanocomposites.
- Author
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Mahdavinia GR, Karimi MH, Soltaniniya M, and Massoumi B
- Subjects
- Anti-Bacterial Agents pharmacology, Carrageenan chemical synthesis, Chitosan chemical synthesis, Escherichia coli drug effects, Hydrogels chemical synthesis, Kinetics, Microbial Sensitivity Tests, Nanocomposites ultrastructure, Spectrometry, X-Ray Emission, Spectroscopy, Fourier Transform Infrared, Staphylococcus aureus drug effects, X-Ray Diffraction, Carrageenan chemistry, Chitosan chemistry, Ciprofloxacin pharmacology, Cross-Linking Reagents chemistry, Drug Liberation, Durapatite chemistry, Hydrogels chemistry, Nanocomposites chemistry
- Abstract
Although the traditional hydrogels have shown great potential applications in designing drug delivery systems, the burst release of drugs remains an issue. In this work, we develop and evaluate a sustained release of ciprofloxacin using chitosan/hydroxyapatite/κ-carrageenan complexes. The size and structure of HA nanoparticles were characterized by X-ray diffraction, transmittance electron microscopy, and Fourier-transform infrared spectroscopy. The ciprofloxacin-loaded hydrogel nanocomposites exhibited antibacterial activity against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria. Due to the introduced HA, the release of ciprofloxacin occurred in a sustained release manner. While the pristine chitosan/κ-carrageenan complex released about 98% of ciprofloxacin during 120 h, only 52 and 66% of the loaded drug was released from hydrogel nanocomposites containing high and low content of HA, respectively. The sustained release of ciprofloxacin from the hydrogel nanocomposites identifies them as a potential candidate for designing drug delivery systems with prolonged release ability., (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Published
- 2019
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