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Your search keyword '"Solorio-Alvarado, Cesar R."' showing total 12 results
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12 results on '"Solorio-Alvarado, Cesar R."'

4. Novel 2-aryl-4-aryloxyquinoline-based fungistatics for Mucor circinelloides. Biological evaluation of activity, QSAR and docking study

Author

Nahide, Pradip D., Alba-Betancourt, Clara, Chávez-Rivera, Rubén, Romo-Rodríguez, Pamela, Solís-Hernández, Manuel, Segura-Quezada, Luis A., Torres-Carbajal, Karina R., Gámez-Montaño, Rocío, Deveze-Álvarez, Martha A., Ramírez-Morales, Marco A., Alonso-Castro, Angel J., Zapata-Morales, Juan R., Ruiz-Padilla, Alan J., Mendoza-Macías, Claudia L., Meza-Carmen, Victor, Cortés-García, Carlos J., Corrales-Escobosa, Alma R., Núñez-Anita, Rosa E., Ortíz-Alvarado, Rafael, Chacón-García, Luis, and Solorio-Alvarado, César R.

Published
2022
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5. A One-Pot Six-Component Reaction for the Synthesis of 1,5-Disubstituted Tetrazol-1,2,3-Triazole Hybrids and Their Cytotoxic Activity against the MCF-7 Cell Line

Author

Aguilar-Morales, Cesia M., primary, Araujo-Huitrado, Jorge Gustavo, additional, López-Hernández, Yamilé, additional, Contreras-Celedón, Claudia, additional, Islas-Jácome, Alejandro, additional, Granados-López, Angelica Judith, additional, Solorio-Alvarado, Cesar R., additional, López, Jesús Adrián, additional, Chacón-García, Luis, additional, and Cortés-García, Carlos J., additional

Published
2021
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8. Gold-catalyzed annulation/fragmentation: formation of free gold carbenes by retro-cyclopropanation

Author

Solorio-Alvarado, Cesar R. and Echavarren, Antonio M.

Subjects
Benzene -- Structure, Benzene -- Chemical properties, Carbenes -- Structure, Carbenes -- Chemical properties, Ring formation (Chemistry) -- Analysis, Gold -- Chemical properties, Chemistry
Abstract

The mechanisms involved in the gold(I)-catalyzed annulations or cyclization of the different alkenylbenzene compounds are discussed. The application of the process in the synthesis of free gold carbenes is also explained.

Published
2010

12. A Metastable Semiquinone Molecular Switch Modulated by Ascorbate/O 2 : A Study from a System Far-From-Equilibrium to Biological Assays in Mitochondria.

Author

Rodríguez-Valdez G, Martínez-Cerda ME, Mejía-Reyes JG, Tapia-Juárez M, Olmos-Orizaba E, Cortés-Rojo C, Cortés-García CJ, Contreras-Celedón CA, Solorio-Alvarado CR, and Chacón-García L

Subjects
Reactive Oxygen Species metabolism, Oxygen chemistry, Oxygen metabolism, Catalase metabolism, Catalase chemistry, Lipid Peroxidation drug effects, Molecular Structure, Saccharomyces cerevisiae metabolism, Saccharomyces cerevisiae drug effects, Mitochondria metabolism, Mitochondria drug effects, Ascorbic Acid chemistry, Ascorbic Acid pharmacology, Benzoquinones chemistry, Benzoquinones pharmacology, Benzoquinones metabolism
Abstract

A molecular switch based on the metastable radical anion derived from a substituted heteroaryl quinone is described. Pyrrolyl quinone thiocyanate (PQ 9) showed an interaction with the fluoride anion that was visible to the naked eye and quantified by UV/vis and 1H and 13 C NMR. The metastable quinoid species formed by the interaction with F - ("ON" state) showed a molecular switching effect autocontrolled by the presence of ascorbate ("OFF" state) and back to the "ON" state by an autooxidation process, measured by visible and UV/vis spectroscopy. Due to its out-of-equilibrium properties and the exchange of matter and energy, a dissipative structural behaviour is proposed. Considering its similarity to the mechanism of coenzyme Q in oxidative phosphophorylation, PQ 9 was evaluated on Saccharomyces cerevisiae mitochondrial function for inhibition of complexes II, III and IV, reactive oxygen species (ROS) production, catalase activity and lipid peroxidation. The results showed that PQ 9 inhibited complex III activity as well as the activity of all electron transport chain (ETC) complexes. In addition, PQ 9 reduced ROS production and catalase activity in yeast. The results suggest that PQ 9 may have potential applications as a new microbicidal compound by inducing ETC dysfunction., (© 2024 Wiley-VCH GmbH.)

Published
2024
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