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344 results on '"Solomayer, E.-F."'

19. 414P The complex relationship between circulating tumor cells (CTCs) and brain metastases (BMs) in metastatic breast cancer (mBC): A retrospective pooled analysis

Author

Pastò, B., Pierga, J-Y., Fehm, T.N., Saenz, J.Á. García, Caldas, C., Gazzaniga, P., Fernandez de Lascoiti, A., De Mattos-Arruda, L., Ignatiadis, M., Generali, D., Riethdorf, S., Solomayer, E-F., Reduzzi, C., Giuliano, M., Puglisi, F., Janni, W., Gerratana, L., Pantel, K., Bidard, F.C., and Cristofanilli, M.

Published
2024
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26. Current clinical practice and outcome of neoadjuvant chemotherapy for early breast cancer: analysis of individual data from 94,638 patients treated in 55 breast cancer centers

Author

Ortmann, Olaf, Blohmer, J.-U., Sibert, N. T., Brucker, S., Janni, W., Wöckel, A., Scharl, A., Dieng, S., Ferencz, J., Inwald, E. C., Wesselmann, S., Kowalski, C., Denisjuk, E., Csorba, R., Rezek, D., Peschel, S., Denschlag, D., Schad, F., Dieterle, D., Lex, B., Rieger, L., Flock, F., Cramer, A., Strittmatter, H.-J., Bettscheider, J., Lindner, C., Stefek, A., Pauker, W., Hönig, A., Schrauder, M., Seeger, D., Kleine-Tebbe, A., Bleimehl, A., Groh, U., Gebauer, G., Vollert, H.-W., Zorr, A., Friedmann, W., Krabisch, P., Fritz, S., Schwämmle, A., Lucke, W., Schmatloch, S., Heyl, W., Deuschle, P., Arfsten, M., Scheler, P., Ruf-Dördelmann, A., Brückner, B., Bauer, L., Koch, M., Monner, J., Nixdorf, A., Merte, A., Beldermann, F., Felberbaum, R., De Wilde, R. L., Bolkenius, P., Lebrecht, A., Solomayer, E.-F., Hartmann, S., and Hartkopf, A.

Subjects
ddc:610, Early breast cancer · Neoadjuvant chemotherapy · Breast cancer centers · Guidelines · Oncobox research, 610 Medizin, skin and connective tissue diseases
Abstract

Neoadjuvant chemotherapy (NACT) is frequently used in patients with early breast cancer. Randomized controlled trials have demonstrated similar survival after NACT or adjuvant chemotherapy (ACT). However, certain subtypes may benefit more when NACT contains regimes leading to high rates of pathologic complete response (pCR) rates. In this study we analyzed data using the OncoBox research from 94,638 patients treated in 55 breast cancer centers to describe the current clinical practice of and outcomes after NACT under routine conditions. These data were compared to patients treated with ACT. 40% of all patients received chemotherapy. The use of NACT increased over time from 5% in 2007 up to 17.3% in 2016. The proportion of patients receiving NACT varied by subtype. It was low in patients with HR-positive/HER2-negative breast cancer (5.8%). However, 31.8% of patients with triple-negative, 31.9% with HR-negative/HER2-positive, and 26.5% with HR-positive/HER2-positive breast cancer received NACT. The rates of pCR were higher in patients with HR-positive/HER2-positive, HR negative/HER2-positive and triple-negative tumors (36, 53 and 38%) compared to HR-positive/HER2-negative tumors (12%). PCR was achieved more often in HER2-positive and triple-negative tumors over time. This is the largest study on use and effects of NACT in German breast cancer centers. It demonstrates the increased use of NACT based on recommendations in current clinical guidelines. An improvement of pCR was shown in particular in HER2-positive and triple-negative breast cancer, which is consistent with data from randomized controlled trails.

Published
2022

28. Modeling the Prognostic Impact of Circulating Tumor Cells Enumeration in Metastatic Breast Cancer for Clinical Trial Design Simulation

Author

Gerratana, L, Pierga, J-Y, Reuben, JM, Davis, AA, Wehbe, FH, Dirix, L, Fehm, T, Nole, F, Gisbert-Criado, R, Mavroudis, D, Grisanti, S, Garcia-Saenz, JA, Stebbing, J, Caldas, C, Gazzaniga, P, Manso, L, Zamarchi, R, Bonotto, M, Fernandez de Lascoiti, A, De Mattos-Arruda, L, Ignatiadis, M, Sandri, M-T, Generali, D, De Angelis, C, Dawson, S-J, Janni, W, Caranana, V, Riethdorf, S, Solomayer, E-F, Puglisi, F, Giuliano, M, Pantel, K, Bidard, F-C, Cristofanilli, M, Gerratana, L, Pierga, J-Y, Reuben, JM, Davis, AA, Wehbe, FH, Dirix, L, Fehm, T, Nole, F, Gisbert-Criado, R, Mavroudis, D, Grisanti, S, Garcia-Saenz, JA, Stebbing, J, Caldas, C, Gazzaniga, P, Manso, L, Zamarchi, R, Bonotto, M, Fernandez de Lascoiti, A, De Mattos-Arruda, L, Ignatiadis, M, Sandri, M-T, Generali, D, De Angelis, C, Dawson, S-J, Janni, W, Caranana, V, Riethdorf, S, Solomayer, E-F, Puglisi, F, Giuliano, M, Pantel, K, Bidard, F-C, and Cristofanilli, M

Abstract

Despite the strong prognostic stratification of circulating tumor cells (CTCs) enumeration in metastatic breast cancer (MBC), current clinical trials usually do not include a baseline CTCs in their design. This study aimed to generate a classifier for CTCs prognostic simulation in existing datasets for hypothesis generation in patients with MBC. A K-nearest neighbor machine learning algorithm was trained on a pooled dataset comprising 2436 individual MBC patients from the European Pooled Analysis Consortium and the MD Anderson Cancer Center to identify patients likely to have CTCs ≥ 5/7 mL blood (StageIVaggressive vs StageIVindolent). The model had a 65.1% accuracy and its prognostic impact resulted in a hazard ratio (HR) of 1.89 (Simulatedaggressive vs SimulatedindolentP < .001), similar to patients with actual CTCs enumeration (HR 2.76; P < .001). The classifier's performance was then tested on an independent retrospective database comprising 446 consecutive hormone receptor (HR)-positive HER2-negative MBC patients. The model further stratified clinical subgroups usually considered prognostically homogeneous such as patients with bone-only or liver metastases. Bone-only disease classified as Simulatedaggressive had a significantly worse overall survival (OS; P < .0001), while patients with liver metastases classified as Simulatedindolent had a significantly better prognosis (P < .0001). Consistent results were observed for patients who had undergone CTCs enumeration in the pooled population. The differential prognostic impact of endocrine- (ET) and chemotherapy (CT) was explored across the simulated subgroups. No significant differences were observed between ET and CT in the overall population, both in terms of progression-free survival (PFS) and OS. In contrast, a statistically significant difference, favoring CT over ET was observed among Simulatedaggressive patients (HR: 0.62; P = .030 and HR: 0.60; P = .037, respectively, for PFS and OS).

Published
2022

36. BEGYN-Studie: Auswirkungen von Bewegung und sportlicher Aktivität bei gynäkologischen Krebspatientinnen auf Lebensqualität, Körperzusammensetzung und prognoserelevante Biomarker

Author

Zemlin, C, additional, Stuhlert, C, additional, Schleicher, J, additional, Wörmann, C, additional, Altmayer, L, additional, Lang, M, additional, Scherer, L-S, additional, Maier, I, additional, Kaiser, E, additional, Stutz, R, additional, Steffgen, G, additional, and Solomayer, E-F, additional

Published
2021
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47. Vaginal operative delivery in Germany: a national survey about experience and self-reported competency.

Author

Hamza, A., Lavin, J. P., Radosa, J. C., Abou-Dakn, M., Peitz, I., Gerlinger, Ch., Meyberg-Solomayer, G., Ströder, R., Juhasz-Böss, I., Solomayer, E.-F., and Takacs, F. Z.

Subjects
DELIVERY (Obstetrics), OBSTETRICIANS, INTERNET surveys, FORCEPS
Abstract

Background: To determine German obstetricians' self-perceived experience with vacuum and forceps deliveries.Patients and Methods: Using a web-based survey, German obstetricians were invited to participate in a survey. This survey was approved by the German society of obstetrics and gynecology.Results: Surveys of 635 obstetricians were received. All obstetricians reported performing significantly less forceps than vacuum deliveries. Almost all obstetricians want to perform more delivery, which indicates the willingness to learn both. More obstetricians felt confident to perform vacuum than forceps. In a similar obstetrical indication, most of the obstetricians would prefer to perform a vacuum assisted delivery. The majority of the obstetricians wished to receive more training in vaginal operative deliveries.Conclusion: Most of the German obstetricians prefer to use vacuum-assisted vaginal deliveries and feel less confident to perform forceps deliveries. Standardized training to improve the quality of care is recommended. [ABSTRACT FROM AUTHOR]

Published
2022
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