Search

Your search keyword '"Soliman, Wafaa"' showing total 177 results
Start Over Author "Soliman, Wafaa"
177 results on '"Soliman, Wafaa"'

10. Nanotechnological prospective for enhancing the antibacterial activity of mupirocin and cinnamon essential oil: a combination therapy.

Author

Aldhubiab, Bandar, Almuqbil, Rashed M., Shehata, Tamer M., Soliman, Wafaa E., and Elsewedy, Heba S.

Subjects
TOPICAL drug administration, ESSENTIAL oils, GRAM-positive bacteria, CINNAMON, GRAM-negative bacteria, MUPIROCIN
Abstract

Backgrounds: The aim of the current study was to develop a distinctive nanolipid formulation, namely, nanostructured lipid carrier (NLC), which would deliver an antibacterial medication such as mupirocin (MP). Additionally, cinnamon essential oil (CEO), which is reported to exhibit antibacterial activity, was utilized in the development process in an attempt to improve the influence of MP. Methods: As a consequence, different MP–NLC formulations were developed using the central composite design (CCD) approach. One optimized formula was selected and incorporated within the pre-formulated gel matrix, providing the MP–NLC-gel formula for efficient topical application. MP–NLC-gel was assessed for its physical characteristics to check its suitability for topical application and evaluated for its in vitro drug release over 6 h. Furthermore, it studied the formulation for its stability at different conditions; 25°C ± 2°C and at 4°C ± 3°C for 6 months. Finally, the formulation was examined for its antibacterial performance against gram-positive and -negative bacteria. Results: The developed topical NLC-gel formulation demonstrated pH 5.8, viscosity 14,510 cP, and spreadability 58.1 mm, which were seemed to be satisfactory properties for successful topical application. The drug was released successfully for over 6 h with 52.9%. Additionally, it was stable in both storage conditions for 6 months since it displayed non-significant variations in its evaluated characteristics compared to those of fresh preparation. Ultimately, the developed gel formulation could inhibit the growth of different bacterial strains, especially gram-negative strains. Conclusion: To sum up, these findings would demonstrate the efficiency of NLC prepared with CEO and incorporating MP to be a promising antibacterial lipid nanocarrier. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

18. Wound Timing: Highlight the Histopathological and Molecular Methods.

Author

Basta Beshay, Rodine Shokry, El Zahed, Eman Salah-El din, Soliman, Wafaa Ibrahim, and Abdel Moawed, Dena Mohamed Naguib

Subjects
FORENSIC pathology, FORENSIC pathologists, FORENSIC sciences, CRIME scenes, IMAGE analysis
Abstract

Background: Although forensic pathology age estimation of a wound is difficult, it can help reconstruct murder scenes and identify potential culprits. Forensic specialists usually focus on two aspects when evaluating wound life and determining how long ago the wound occurred. Recent developments in forensic techniques, particularly in high-throughput analyses, have allowed for the simultaneous evaluation of several markers and molecular and cellular levels of material analysis. Aim: To evaluate valuable additional information offered by each marker, summarize recent literature, and offer an update on wound-age estimation in forensic pathology. With the intention of providingsome insight for future research, prospects for evaluating wound age in forensic practice are finally examined. Conclusions: Although forensic pathologists find it difficult to determine the age of wounds, doing so can help reconstruct crime scenes and help apprehend suspects. In circumstances where several traumas are sustained by various offenders, forensic pathologists must determine the chronology and sequence of injuries because the severity of an injury usually determines the severity of punishment. Wound tracing, photographic recording (including image analysis), biophysical approaches, and/or invasive protocols requiring wound biopsies are examples of protocols that can be used to do the assessment. We give a summary of some of the most frequently required and utilized methods in this article: (a) Preclinical and animal models, such as those involving incisions, excisions, burns, and damaged wounds; (b) techniques for assessing the rate of healing, image-based wound analysis, biophysical evaluation, histological, immunological, and biochemical assays; and techniques for assessing the healing progression. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

32. Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential

Author

Shinu, Pottathil, primary, Gupta, Girdhari Lal, additional, Sharma, Manu, additional, Khan, Shahzad, additional, Goyal, Manoj, additional, Nair, Anroop B., additional, Kumar, Manish, additional, Soliman, Wafaa E., additional, Rahman, Aminur, additional, Attimarad, Mahesh, additional, Venugopala, Katharigatta N., additional, and Altaweel, Abdullah Abdulhamid Ahmed, additional

Published
2023
Full Text
View/download PDF

46. Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens

Author

Khayyat, Ahdab N., primary, Hegazy, Wael A. H., additional, Shaldam, Moataz A., additional, Mosbah, Rasha, additional, Almalki, Ahmad J., additional, Ibrahim, Tarek S., additional, Khayat, Maan T., additional, Khafagy, El-Sayed, additional, Soliman, Wafaa E., additional, and Abbas, Hisham A., additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results