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Your search keyword '"Soliman, Bram G"' showing total 24 results
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24 results on '"Soliman, Bram G"'

2. Harnessing Macromolecular Chemistry to Design Hydrogel Micro- and Macro-Environments

Author

Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Soliman, Bram G., Longoni, Alessia, Major, Gretel S., Lindberg, Gabriella C.J., Choi, Yu Suk, Zhang, Yu Shrike, Woodfield, Tim B.F., Lim, Khoon S., Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Soliman, Bram G., Longoni, Alessia, Major, Gretel S., Lindberg, Gabriella C.J., Choi, Yu Suk, Zhang, Yu Shrike, Woodfield, Tim B.F., and Lim, Khoon S.

Published
2024

4. 3D Volumetric Mechanosensation of MCF7 Breast Cancer Spheroids in a Linear Stiffness Gradient GelAGE

Author

Vahala, Danielle, primary, Amos, Sebastian E., additional, Sacchi, Marta, additional, Soliman, Bram G., additional, Hepburn, Matt S., additional, Mowla, Alireza, additional, Li, Jiayue, additional, Jeong, Ji Hoon, additional, Astell, Chrissie, additional, Hwang, Yongsung, additional, Kennedy, Brendan F., additional, Lim, Khoon S., additional, and Choi, Yu Suk, additional

Published
2023
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5. Programming Delayed Dissolution Into Sacrificial Bioinks For Dynamic Temporal Control of Architecture within 3D-Bioprinted Constructs

Author

Soliman, Bram G., Longoni, Alessia, Wang, Mian, Li, Wanlu, Bernal, Paulina N., Cianciosi, Alessandro, Lindberg, Gabriella C.J., Malda, Jos, Groll, Juergen, Jungst, Tomasz, Levato, Riccardo, Rnjak-Kovacina, Jelena, Woodfield, Tim B.F., Zhang, Yu Shrike, Lim, Khoon S., Soliman, Bram G., Longoni, Alessia, Wang, Mian, Li, Wanlu, Bernal, Paulina N., Cianciosi, Alessandro, Lindberg, Gabriella C.J., Malda, Jos, Groll, Juergen, Jungst, Tomasz, Levato, Riccardo, Rnjak-Kovacina, Jelena, Woodfield, Tim B.F., Zhang, Yu Shrike, and Lim, Khoon S.

Abstract

Sacrificial printing allows introduction of architectural cues within engineered tissue constructs. This strategy adopts the use of a 3D-printed sacrificial ink that is embedded within a bulk hydrogel which is subsequently dissolved to leave open-channels. However, current conventional sacrificial inks do not recapitulate the dynamic nature of tissue development, such as the temporal presentation of architectural cues matching cellular requirements during different stages of maturation. To address this limitation, a new class of sacrificial inks is developed that exhibits tailorable and programmable delayed dissolution profiles (1–17 days), by exploiting the unique ability of the ruthenium complex and sodium persulfate initiating system to crosslink native tyrosine groups present in non-chemically modified gelatin. These novel sacrificial inks are also shown to be compatible with a range of biofabrication technologies, including extrusion-based printing, digital-light processing, and volumetric bioprinting. Further embedding these sacrificial templates within cell-laden bulk hydrogels displays precise control over the spatial and temporal introduction of architectural features into cell-laden hydrogel constructs. This approach demonstrates the unique capacity of delaying dissolution of sacrificial inks to modulate cell behavior, improving the deposition of mineralized matrix and capillary-like network formation in osteogenic and vasculogenic culture, respectively.

Published
2023

6. Programming Delayed Dissolution Into Sacrificial Bioinks For Dynamic Temporal Control of Architecture within 3D-Bioprinted Constructs

Author

Equine Musculoskeletal Biology, CS_Locomotion, Soliman, Bram G., Longoni, Alessia, Wang, Mian, Li, Wanlu, Bernal, Paulina N., Cianciosi, Alessandro, Lindberg, Gabriella C.J., Malda, Jos, Groll, Juergen, Jungst, Tomasz, Levato, Riccardo, Rnjak-Kovacina, Jelena, Woodfield, Tim B.F., Zhang, Yu Shrike, Lim, Khoon S., Equine Musculoskeletal Biology, CS_Locomotion, Soliman, Bram G., Longoni, Alessia, Wang, Mian, Li, Wanlu, Bernal, Paulina N., Cianciosi, Alessandro, Lindberg, Gabriella C.J., Malda, Jos, Groll, Juergen, Jungst, Tomasz, Levato, Riccardo, Rnjak-Kovacina, Jelena, Woodfield, Tim B.F., Zhang, Yu Shrike, and Lim, Khoon S.

Published
2023

7. Programming Delayed Dissolution Into Sacrificial Bioinks For Dynamic Temporal Control of Architecture within 3D-Bioprinted Constructs

Author

MKA/BT Onderzoek, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Other research (not in main researchprogram), Soliman, Bram G., Longoni, Alessia, Wang, Mian, Li, Wanlu, Bernal, Cianciosi, Alessandro, Lindberg, Gabriella C.J., Malda, Jos, Groll, Juergen, Jungst, Tomasz, Levato, Riccardo, Rnjak-Kovacina, Jelena, Woodfield, Tim B.F., Zhang, Yu Shrike, Lim, Khoon S., MKA/BT Onderzoek, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Other research (not in main researchprogram), Soliman, Bram G., Longoni, Alessia, Wang, Mian, Li, Wanlu, Bernal, Cianciosi, Alessandro, Lindberg, Gabriella C.J., Malda, Jos, Groll, Juergen, Jungst, Tomasz, Levato, Riccardo, Rnjak-Kovacina, Jelena, Woodfield, Tim B.F., Zhang, Yu Shrike, and Lim, Khoon S.

Published
2023

8. Programming Delayed Dissolution Into Sacrificial Bioinks For Dynamic Temporal Control of Architecture within 3D‐Bioprinted Constructs (Adv. Funct. Mater. 8/2023)

Author

Soliman, Bram G., primary, Longoni, Alessia, additional, Wang, Mian, additional, Li, Wanlu, additional, Bernal, Paulina N., additional, Cianciosi, Alessandro, additional, Lindberg, Gabriella C.J., additional, Malda, Jos, additional, Groll, Juergen, additional, Jungst, Tomasz, additional, Levato, Riccardo, additional, Rnjak‐Kovacina, Jelena, additional, Woodfield, Tim B. F., additional, Zhang, Yu Shrike, additional, and Lim, Khoon S., additional

Published
2023
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9. Development and Characterization of Gelatin-Norbornene Bioink to Understand the Interplay between Physical Architecture and Micro-capillary Formation in Biofabricated Vascularized Constructs

Author

MKA/BT Onderzoek, Regenerative Medicine and Stem Cells, Soliman, Bram G, Major, Gretel S, Atienza-Roca, Pau, Murphy, Caroline A, Longoni, Alessia, Alcala-Orozco, Cesar R, Rnjak-Kovacina, Jelena, Gawlitta, Debby, Woodfield, Tim Bf, Lim, Khoon S, MKA/BT Onderzoek, Regenerative Medicine and Stem Cells, Soliman, Bram G, Major, Gretel S, Atienza-Roca, Pau, Murphy, Caroline A, Longoni, Alessia, Alcala-Orozco, Cesar R, Rnjak-Kovacina, Jelena, Gawlitta, Debby, Woodfield, Tim Bf, and Lim, Khoon S

Published
2022

10. Development and Characterization of Gelatin‐Norbornene Bioink to Understand the Interplay between Physical Architecture and Micro‐Capillary Formation in Biofabricated Vascularized Constructs (Adv. Healthcare Mater. 2/2022)

Author

Soliman, Bram G., primary, Major, Gretel S., additional, Atienza‐Roca, Pau, additional, Murphy, Caroline A., additional, Longoni, Alessia, additional, Alcala‐Orozco, Cesar R., additional, Rnjak‐Kovacina, Jelena, additional, Gawlitta, Debby, additional, Woodfield, Tim B. F., additional, and Lim, Khoon S., additional

Published
2022
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11. Development and Characterization of Gelatin‐Norbornene Bioink to Understand the Interplay between Physical Architecture and Micro‐Capillary Formation in Biofabricated Vascularized Constructs

Author

Soliman, Bram G., primary, Major, Gretel S., additional, Atienza‐Roca, Pau, additional, Murphy, Caroline A., additional, Longoni, Alessia, additional, Alcala‐Orozco, Cesar R., additional, Rnjak‐Kovacina, Jelena, additional, Gawlitta, Debby, additional, Woodfield, Tim B. F., additional, and Lim, Khoon S., additional

Published
2021
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12. Injection‐Free Delivery of MSC‐Derived Extracellular Vesicles for Myocardial Infarction Therapeutics

Author

Tang, Junnan, primary, Cui, Xiaolin, additional, Zhang, Zenglei, additional, Xu, Yanyan, additional, Guo, Jiacheng, additional, Soliman, Bram G, additional, Lu, Yongzheng, additional, Qin, Zhen, additional, Wang, Qiguang, additional, Zhang, Hu, additional, Lim, Khoon S, additional, Woodfield, Tim B F, additional, and Zhang, Jinying, additional

Published
2021
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13. Correction to: Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape Fidelity (Adv. Healthcare Mater, (2020), 9, (1901667), 10.1002/adhm.201901667)

Author

Cui, Xiaolin, Soliman, Bram G., Alcala-Orozco, Cesar R., Li, Jun, Vis, Michelle A.M., Santos, Miguel, Wise, Steven G., Levato, Riccardo, Malda, Jos, Woodfield, Tim B.F., Rnjak-Kovacina, Jelena, Lim, Khoon S., Equine Musculoskeletal Biology, and dES RMSC

Subjects
Biomaterials, Biomedical Engineering, Pharmaceutical Science
Abstract

Adv. Healthcare Mater. 2020, 9, 1901667 DOI: 10.1002/adhm.201901667 In the original version of this article, there was a mistake in Figure 3 due to errors during the compilation of the images. The correct figure is shown below. This mistake does not affect the results, discussions and conclusions published in this work, and the authors apologize for any confusion caused.

Published
2020

14. Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape Fidelity

Author

Cui, Xiaolin, Soliman, Bram G, Alcala-Orozco, Cesar R, Li, Jun, Vis, Michelle A M, Santos, Miguel, Wise, Steven G, Levato, Riccardo, Malda, Jos, Woodfield, Tim B F, Rnjak-Kovacina, Jelena, Lim, Khoon S, LS Equine Muscoskeletal Biology, dES RMSC, LS Equine Muscoskeletal Biology, dES RMSC, and Orthopaedic Biomechanics

Subjects
Materials science, 0206 medical engineering, Biomedical Engineering, Silk, Pharmaceutical Science, Fibroin, Nanotechnology, Cell Count, 02 engineering and technology, macromolecular substances, 010402 general chemistry, Elastomer, SDG 3 – Goede gezondheid en welzijn, photo‐polymerization, 01 natural sciences, Biomaterials, SDG 3 - Good Health and Well-being, Humans, cartilage, visible light, biofabrication, fungi, technology, industry, and agriculture, Chemical modification, High cell, Hydrogels, Bond formation, 021001 nanoscience & nanotechnology, 020601 biomedical engineering, 3. Good health, 0104 chemical sciences, SILK, Cartilage, Photo-polymerization, silk fibroin, Self-healing hydrogels, 0210 nano-technology, Fibroins, Chondrogenesis, Biofabrication
Abstract

Silk fibroin hydrogels crosslinked through di-tyrosine bonds are clear, elastomeric constructs with immense potential in regenerative medicine applications. In this study, demonstrated is a new visible light-mediated photoredox system for di-tyrosine bond formation in silk fibroin that overcomes major limitations of current conventional enzymatic-based crosslinking. This photomediated system rapidly crosslinks silk fibroin (−1) while retaining high cell viability (>80%). The photocrosslinked silk hydrogels present more stable mechanical properties which do not undergo spontaneous transition to stiff, β-sheet-rich networks typically seen for enzymatically crosslinked systems. These hydrogels also support long-term culture of human articular chondrocytes, with excellent cartilage tissue formation. This system also facilitates the first demonstration of biofabrication of silk fibroin constructs in the absence of chemical modification of the protein structure or rheological additives. Cell-laden constructs with complex, ordered, graduated architectures, and high resolution (40 µm) are fabricated using the photocrosslinking system, which cannot be achieved using the enzymatic crosslinking system. Taken together, this work demonstrates the immense potential of a new crosslinking approach for fabrication of elastomeric silk hydrogels with applications in biofabrication and tissue regeneration.

Published
2020

15. Correction to: Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape Fidelity (Adv. Healthcare Mater, (2020), 9, (1901667), 10.1002/adhm.201901667)

Author

Equine Musculoskeletal Biology, dES RMSC, Cui, Xiaolin, Soliman, Bram G., Alcala-Orozco, Cesar R., Li, Jun, Vis, Michelle A.M., Santos, Miguel, Wise, Steven G., Levato, Riccardo, Malda, Jos, Woodfield, Tim B.F., Rnjak-Kovacina, Jelena, Lim, Khoon S., Equine Musculoskeletal Biology, dES RMSC, Cui, Xiaolin, Soliman, Bram G., Alcala-Orozco, Cesar R., Li, Jun, Vis, Michelle A.M., Santos, Miguel, Wise, Steven G., Levato, Riccardo, Malda, Jos, Woodfield, Tim B.F., Rnjak-Kovacina, Jelena, and Lim, Khoon S.

Published
2020

16. Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape Fidelity

Author

LS Equine Muscoskeletal Biology, dES RMSC, Cui, Xiaolin, Soliman, Bram G, Alcala-Orozco, Cesar R, Li, Jun, Vis, Michelle A M, Santos, Miguel, Wise, Steven G, Levato, Riccardo, Malda, Jos, Woodfield, Tim B F, Rnjak-Kovacina, Jelena, Lim, Khoon S, LS Equine Muscoskeletal Biology, dES RMSC, Cui, Xiaolin, Soliman, Bram G, Alcala-Orozco, Cesar R, Li, Jun, Vis, Michelle A M, Santos, Miguel, Wise, Steven G, Levato, Riccardo, Malda, Jos, Woodfield, Tim B F, Rnjak-Kovacina, Jelena, and Lim, Khoon S

Published
2020

17. Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape Fidelity: Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape Fidelity (Adv. Healthcare Mater, (2020), 9, (1901667), 10.1002/adhm.201901667)

Author

Orthopaedie Onderzoek, Other research (not in main researchprogram), Regenerative Medicine and Stem Cells, Cui, Xiaolin, Soliman, Bram G., Alcala-Orozco, Cesar R., Li, Jun, Vis, Michelle A.M., Santos, Miguel, Wise, Steven G., Levato, Riccardo, Malda, Jos, Woodfield, Tim B.F., Rnjak-Kovacina, Jelena, Lim, Khoon S., Orthopaedie Onderzoek, Other research (not in main researchprogram), Regenerative Medicine and Stem Cells, Cui, Xiaolin, Soliman, Bram G., Alcala-Orozco, Cesar R., Li, Jun, Vis, Michelle A.M., Santos, Miguel, Wise, Steven G., Levato, Riccardo, Malda, Jos, Woodfield, Tim B.F., Rnjak-Kovacina, Jelena, and Lim, Khoon S.

Published
2020

18. Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape Fidelity

Author

Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Cui, Xiaolin, Soliman, Bram G., Alcala-Orozco, Cesar R., Li, Jun, Vis, Michelle A.M., Santos, Miguel, Wise, Steven G., Levato, Riccardo, Malda, Jos, Woodfield, Tim B.F., Rnjak-Kovacina, Jelena, Lim, Khoon S., Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Cui, Xiaolin, Soliman, Bram G., Alcala-Orozco, Cesar R., Li, Jun, Vis, Michelle A.M., Santos, Miguel, Wise, Steven G., Levato, Riccardo, Malda, Jos, Woodfield, Tim B.F., Rnjak-Kovacina, Jelena, and Lim, Khoon S.

Published
2020

22. Thermoresponsive Injectable Hydrogels Cross-Linked by Native Chemical Ligation

Author

Sub Drug delivery, UIPS - Utrecht Institute for Pharmaceutical Sciences, Sub Medicinal Chemistry & Chemical biol., Pharmaceutics, Molecular Pharmacy, Boere, Kristel W M, Soliman, Bram G., Rijkers, Dirk T S, Hennink, Wim E., Vermonden, Tina, Sub Drug delivery, UIPS - Utrecht Institute for Pharmaceutical Sciences, Sub Medicinal Chemistry & Chemical biol., Pharmaceutics, Molecular Pharmacy, Boere, Kristel W M, Soliman, Bram G., Rijkers, Dirk T S, Hennink, Wim E., and Vermonden, Tina

Published
2014

24. Droplet-based microfluidics for engineering shape-controlled hydrogels with stiffness gradient.

Author

Soliman BG, Chin IL, Li Y, Ishii M, Ho MH, Doan VK, Cox TR, Wang PY, Lindberg GCJ, Zhang YS, Woodfield TBF, Choi YS, and Lim KS

Subjects
Humans, Mesenchymal Stem Cells cytology, Hydrogels chemistry, Tissue Engineering, Microfluidics methods, Microfluidics instrumentation
Abstract

Current biofabrication strategies are limited in their ability to replicate native shape-to-function relationships, that are dependent on adequate biomimicry of macroscale shape as well as size and microscale spatial heterogeneity, within cell-laden hydrogels. In this study, a novel diffusion-based microfluidics platform is presented that meets these needs in a two-step process. In the first step, a hydrogel-precursor solution is dispersed into a continuous oil phase within the microfluidics tubing. By adjusting the dispersed and oil phase flow rates, the physical architecture of hydrogel-precursor phases can be adjusted to generate spherical and plug-like structures, as well as continuous meter-long hydrogel-precursor phases (up to 1.75 m). The second step involves the controlled introduction a small molecule-containing aqueous phase through a T-shaped tube connector to enable controlled small molecule diffusion across the interface of the aqueous phase and hydrogel-precursor. Application of this system is demonstrated by diffusing co-initiator sodium persulfate (SPS) into hydrogel-precursor solutions, where the controlled SPS diffusion into the hydrogel-precursor and subsequent photo-polymerization allows for the formation of unique radial stiffness patterns across the shape- and size-controlled hydrogels, as well as allowing the formation of hollow hydrogels with controllable internal architectures. Mesenchymal stromal cells are successfully encapsulated within hollow hydrogels and hydrogels containing radial stiffness gradient and found to respond to the heterogeneity in stiffness through the yes-associated protein mechano-regulator. Finally, breast cancer cells are found to phenotypically switch in response to stiffness gradients, causing a shift in their ability to aggregate, which may have implications for metastasis. The diffusion-based microfluidics thus finds application mimicking native shape-to-function relationship in the context of tissue engineering and provides a platform to further study the roles of micro- and macroscale architectural features that exist within native tissues., (Creative Commons Attribution license.)

Published
2024
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