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177 results on '"Soler, J. J."'

25. Support for a Colleague

Author

Alatalo, R. V., Aragón, S., Avilés, J. M., Barbosa, A., Gomes, C. Bessa, Cadée, N., Christe, P., Cuervo, J. J., Díaz, M., Erritzøe, J., Galeotti, P., Garamszegi, L. Z., Gil, D., Gontard-Danek, M., Legendre, S., Martin, T. E., Martínez, J., Martín-Vivaldi, M., Martínez, J. G., Merino, S., Moreno, J., Mousseau, Tim, Ninni, P., Petrie, M., Pulido, F., Rubolini, D., Saino, N., Soler, J. J., Soler, M., Spottiswoode, C., Szép, T., Thornhill, R., Zamora, C., and Sacchi, Roberto

Published
2004

27. Density-dependent and geographical variation in bird immune response

Author

Meller, A. P., Martin-Vivaldi, M., Merino, S., and Soler, J. J.

Subjects
Birds -- Physiological aspects, Immune response -- Physiological aspects, T cells -- Physiological aspects, Environmental issues
Abstract

A study of the T-cell mediated immune response in various altricial bird species helps in understanding the latitudinal differences in population density that highly affect immune responses. The analysis reveals that the birds in areas with higher density give more resources to immune response, hence proving that the density and immune response have a positive relationship between them.

Published
2006

28. Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

Author

Fabbri, Leonardo M., Calverley, Peter M. A., Jose Luis Izquierdo Alonso, Bundschuh, Daniela S., Manja, Brose, Martinez, Fernando J., Rabe, Kf M., Study Groups Abdulla, M., Abdullah, I., Adler, M., Aguilaniu, Albert, I., Almonacid, C., Altés, A., Amaducci, S., Angrill, J., Antonana, J. M., Artner, H., Balint, B., Bantje, T. A., Barbe, F., Bateman, E., Bauchnect, E., Belda, J., Bernabeu, L., Bettendorf, A., Blagden, M., Blanquer, R., Blecher, L., Bonnaud, F., Bourbeau, J., Boyer, G. R., Brotons, C., Bruning, A. H., Bucca, C., Burns, G. E., Von Der Heydt, B. B., Caldwell, Canonica, G. W., Carter, J., Chan, V., Chapman, K. R., Chapman, G., Cheung, D., Chiner, E., Chopra, A., Clini, E., Coulet, P., Craig, B., Croonenborghs, L., Czompó, M., Dal Negro, R. W., Dapper, T., De Graaff, C. S., Ramos Pde, L., De Munck, D. R., Decramer, M., Delobbe, A., Denier, W., De Teresa, L., Dhar, A., Di Maria, G., Dupouy, J., Duschek, G., Echave, J., Esteban, C., Farmer, I. S., Flemale, A., Fletcher, P., Foden, Fouquert, L., Franz, K. H., Frognier, Gagnon, M., Garcia, Mdel M., Garelli, G., Gehling, U., Ginko, T., Glekin, B., Gooding, T., Graham, A., Greillier, P., Greses, J. V., Grillenberger, J., Gross, B., Grygier, H., Gyori, Z., Harper, Henein, S., Heredia, J. L., Hernandez, P., Hoefer, M., Hoffstein, V., Holgate, K., Holler, W., Holub, G., Homik, L., Houle, P. A., Hutter, C., Hyvernat, P., Irusen, E. M., Jackson, A., Janisty, W., Jasnot, J. Y., Joubert, J., Juhasz, G., Jullian, H., Kafe, H., Kelly, P., Kidney, J., Killian, K., Kinch, H., Kirsten, D. L., Kleinecke Pohl, U., Korlipara, K., Krige, L. P., Kroker, A., Kuipers, A. F., Labrecque, M., Larivee, P., Laskowitz, C., Le Merre, C., Lemoigne, F., Ludwig Sengpiel, A., Luengo, M., Luton, R., Macnee, W., Ali, S. M., Maltais, F., Mansur, A., Marciniuk, D., Marin, A., Martin, P., Martinot, J. B., Mazza, F., Bride, M. C., Mcdonald, B., Mckinnon, C., Mclvor, A., Mcnally, D., Mengeot, P. M., Messner, J., Moder, G., Mooney, P., Moretti, A. M., Muller, D., Murio, C., Nardini, S., Nel, A., Ochoa, Saracho Jo, D. E., Paggiaro, P., Paradis, B., Patrick, J., Peche, R., Pellicer, C., Perez, T., Perez, E., De Llano, L. A., Philteos, G., Pieters, W. R., Pigearias, B., Pohl, W., Popovic, R., Prins, M., Querfurt, H., Rajkay, K., Ras, G., Road, J., Roig, J., Roldaan, A. C., Rolke, M., Rozen, D., Sanchez Toril, F., Savani, N., Savary, L., Schiavina, M., Schiesbühl, H., Schreurs, A. J., Schröder Babo, W., Schurmann, W., Seiz, V., Sevette, C., Sharma, R., Shum, C., Damsté, H. E., Smithers, A., Soler, J. J., Steffen, H., Steinhauser, U., Sweilem, M., Tellier, G., Terol, B., Terzano, Claudio, Timar, M., Toma, G., Monserrat, P. T., Trauth, H. A., Valyon, E., Brande Van Den, Van Noord, J. A., Vaquer, J. V., Hernandez Hector, H. V., Vereecken, G., Verkindre, C., Vigh, M., Viljoen, J. J., Vincken, W., Vinkler, I., Visser, S., Volgmann, L., Vorderstrasse, W., Voves, R., Vrancken, F., Weber, H. H., Wielders, P. L., Willoughby, P., Wurtz, J., Yang, W., Zabaleta, M., Zachgo, W., Zanini, A., Zeiner, M., Michael, H., Janistyn, W., Abdulla, R., Terzano, C., Fabbri, L., Barbaro, M. P., Izquierdo, J. L., Ramos, Pde L., and Harper, Ochoa

Subjects
Chronic bronchitis, medicine.drug_class, glucocorticosteroids, Placebo, exacerbations, Bronchodilator, medicine, COPD, humans, Roflumilast, Intention-to-treat analysis, business.industry, Body weight, chronic bronchitis, emphysema, inflammation, lung function, phosphodiesterase 4 inhibitor, PDE4, General Medicine, Tiotropium bromide, medicine.disease, respiratory tract diseases, Anesthesia, Salmeterol, business, medicine.drug
Abstract

Summary Background Patients with chronic obstructive pulmonary disease (COPD) have few options for treatment. The efficacy and safety of the phosphodiesterase-4 inhibitor roflumilast have been investigated in studies of patients with moderate-to-severe COPD, but not in those concomitantly treated with longacting inhaled bronchodilators. The effect of roflumilast on lung function in patients with COPD that is moderate to severe who are already being treated with salmeterol or tiotropium was investigated. Methods In two double-blind, multicentre studies done in an outpatient setting, after a 4-week run-in, patients older than 40 years with moderate-to-severe COPD were randomly assigned to oral roflumilast 500 μg or placebo once a day for 24 weeks, in addition to salmeterol (M2-127 study) or tiotropium (M2-128 study). The primary endpoint was change in prebronchodilator forced expiratory volume in 1 s (FEV 1 ). Analysis was by intention to treat. The studies are registered with ClinicalTrials.gov, number NCT00313209 for M2-127, and NCT00424268 for M2-128. Findings In the salmeterol plus roflumilast trial, 466 patients were assigned to and treated with roflumilast and 467 with placebo; in the tiotropium plus roflumilast trial, 371 patients were assigned to and treated with roflumilast and 372 with placebo. Compared with placebo, roflumilast consistently improved mean prebronchodilator FEV 1 by 49 mL (p 1 was noted in both groups. Furthermore, roflumilast had beneficial effects on other lung function measurements and on selected patient-reported outcomes in both groups. Nausea, diarrhoea, weight loss, and, to a lesser extent, headache were more frequent in patients in the roflumilast groups. These adverse events were associated with increased patient withdrawal. Interpretation Roflumilast improves lung function in patients with COPD treated with salmeterol or tiotropium, and could become an important treatment for these patients. Funding Nycomed.

Published
2009
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30. Assessing the Effects of Climate on Host-Parasite Interactions: A Comparative Study of European Birds and their Parasites

Author

MØLLER, A. P., MERINO, S., SOLER, J. J., ANTONOV, A., BADÁS, E. P., CALERO-TORRALBO, M. A., DE LOPE, F., EEVA, T., FIGUEROLA, J., FLENSTED-JENSEN, E., GARAMSZEGI, L. Z., GONZÁLEZ-BRAOJOS, S., GWINNER, H., HANSSEN, S. A., HEYLEN, D., ILMONEN, P., KLARBORG, K., KORPIMÄKI, E., MARTÍNEZ, J., MARTÍNEZ-DE LA PUENTE, J., MARZAL, A., MATTHYSEN, E., MATYJASIAK, P., MOLINA-MORALES, M., MORENO, J., MOUSSEAU, T. A., NIELSEN, J. T., PAP, P. L., RIVERO DE AGUILAR, J., SHURULINKOV, P., SLAGSVOLD, T., SZÉP, T., SZÖLLŐSI, E., TÖRÖK, J., VACLAV, R., VALERA, F., ZIANE, N.

Subjects
education
Published
2013

47. Density-dependent and geographical variation in bird immune response.

Author

P. Møller, A., Martín-Vivaldi, M., Merino, S., and Soler, J. J.

Subjects
ORNITHOLOGY, PARASITISM, IMMUNE response, BABY birds, BIRD behavior, ANIMAL young, PARASITIC birds, NATURAL selection, POPULATION density
Abstract

Latitudinal gradients in parasitism are common, causing differences in the intensity of parasite-mediated natural selection. Such differences in selection pressures should affect optimal investment in anti-parasite defense, because defense levels should increase in response to increased intensity of parasite-induced selection. Likewise, latitudinal differences in population density may affect immune responses either by selecting for higher levels or defense, or by suppressing resources needed for mounting efficient immune responses. We tested these predictions in a study of T-cell mediated immune response in altricial bird species in subtropical Spain and temperate Denmark. There were highly consistent levels of T-cell mediated response between nestlings and adults in the two areas, with nestlings having stronger responses than adults. In addition, there were highly consistent levels of immune response in nestlings and adults between the two areas, with responses being consistently stronger in Denmark than in Spain, particularly in adults. Population density was much higher in Denmark than in Spain. We found evidence of density-dependent immune response in nestlings and adults, as shown by differences in T-cell response between study areas being positively related to differences in density. Given that the relationship between density and immune response was positive, we can reject the hypothesis that higher population densities suppressed immune response. Therefore, our results support the hypothesis that birds in areas with higher density allocate more resources to immune response, particularly in adults, suggesting that density-dependent effects of parasitism have selected for allocation strategies that minimize the risk of parasitism. [ABSTRACT FROM AUTHOR]

Published
2006
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