40 results on '"Soldini E"'
Search Results
2. Widespread pain is associated with greater perceived pain and disability, but not with psychological features in patients with cervical radiculopathy
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Falla, D., primary, Peolsson, A., additional, Heneghan, N., additional, Rushton, A., additional, Soldini, E., additional, Löfgren, H., additional, Zsigmond, P., additional, Dedering, Å., additional, and Barbero, M., additional
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- 2017
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3. Association between pain extent and health status in whiplash associated disorders
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Barbero, M., primary, Peolsson, A., additional, Peterson, G., additional, Ludvigsson, M. Landén, additional, Soldini, E., additional, Schneebeli, A., additional, and Falla, D., additional
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- 2017
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4. Perceived pain extent is associated with disability, depression and self-efficacy in individuals with whiplash-associated disorders
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Falla, D., primary, Peolsson, A., additional, Peterson, G., additional, Ludvigsson, M.L., additional, Soldini, E., additional, Schneebeli, A., additional, and Barbero, M., additional
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- 2016
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5. P144 – 1925 Longitudinal neurodevelopmental evolution in children with severe non-progressive encephalopathy
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Antonini, U, primary, Soldini, E, additional, D'Apuzzo, V, additional, Brunner, R, additional, and Ramelli, GP, additional
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- 2013
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6. Effectiveness of crisis resolution home treatment for the management of acute psychiatric crises in Southern Switzerland: a natural experiment based on geography
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Emiliano Soldini, Maddalena Alippi, Maria Caiata Zufferey, Angela Lisi, Mario Lucchini, Emiliano Albanese, Raffaella Ada Colombo, Simona Rossa, Emilio Carlo Bolla, Zefiro Benedetto Mellacqua, Giuseppina Larghi, Severino Cordasco, Wolfram Kawohl, Luca Crivelli, Rafael Traber, Soldini, E, Alippi, M, Zufferey, M, Lisi, A, Lucchini, M, Albanese, E, Colombo, R, Rossa, S, Bolla, E, Mellacqua, Z, Larghi, G, Cordasco, S, Kawohl, W, Crivelli, L, and Traber, R
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Hospitalization ,Inpatient treatment ,Psychiatry and Mental health ,Acute psychiatric crise ,Caregivers ,Geography ,Mental Disorders ,Effectivene ,Humans ,Quasi-experimental design ,Switzerland ,Crisis Resolution Home Treatment - Abstract
Background Crisis Resolution Home Treatment (CRHT) is an alternative to inpatient treatment for acute psychiatric crises management. However, evidence on CRHT effectiveness is still limited. In the Canton of Ticino (Southern Switzerland), in 2016 the regional public psychiatric hospital replaced one acute ward with a CRHT. The current study was designed within this evaluation setting to assess the effectiveness of CRHT compared to standard inpatient treatment. Methods CRHT was offered to patients aged 18 to 65 with an acute psychiatric crisis that would have required hospitalization. We used a natural experiment based on geography, where intervention and control groups were formed according to the place of residence. Primary endpoints were reduction of psychiatric symptoms at discharge measured using the Health of the Nation Outcome Scales, treatment duration in days, and rate and length of readmissions during a two-year follow-up period after discharge. Safety during the treatment period was measured with the number of serious adverse events (suicide/suicide attempts, major self-harm episodes, acute alcohol/drug intoxications, aggressions to caregivers or family members). We used linear, log-linear and logistic regression models with propensity scores for the main analysis. Results We enrolled 321 patients; 67 were excluded because the treatment period was too short and 17 because they were transferred before the end of the treatment. Two hundred thirty-seven patients were available for data analysis, 93 in the intervention group and 144 in the control group. No serious adverse event was observed during the treatment period in both groups. Reduction of psychiatric symptoms at discharge (p-value = 0.359), readmission rates (p-value = 0.563) and length of readmissions (p-value = 0.770) during the two-year follow-up period did not differ significantly between the two groups. Treatment duration was significantly higher in the treatment group (+ 29.6% on average, p-value = 0.002). Conclusions CRHT was comparable to standard hospitalization in terms of psychiatric symptoms reduction, readmission rates and length of readmissions, but it was also characterized by a longer first treatment period. However, observational evidence following the study indicated that CRHT duration constantly lowered over time since its introduction in 2016 and became comparable to hospitalization, showing therefore to be an effective alternative also in terms of treatment length. Trial registration ISRCTN38472626 (17/11/2020, retrospectively registered).
- Published
- 2021
7. Home Treatment for Acute Mental Health Care: Protocol for the Financial Outputs, Risks, Efficacy, Satisfaction Index and Gatekeeping of Home Treatment (FORESIGHT) Study
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Emilio Bolla, Maddalena Alippi, Maria Caiata-Zufferey, Giuseppina Larghi, Severino Cordasco, Wolfram Kawohl, Sara Levati, Raffaella Ada Colombo, Emiliano Soldini, Mario Lucchini, Luca Crivelli, Zefiro Mellacqua, Emiliano Albanese, Angela Lisi, Rafael Traber, Simona Rossa, Levati, S, Mellacqua, Z, Caiata-Zufferey, M, Soldini, E, Albanese, E, Alippi, M, Bolla, E, Colombo, R, Cordasco, S, Kawohl, W, Larghi, G, Lisi, A, Lucchini, M, Rossa, S, Traber, R, and Crivelli, L
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medicine.medical_specialty ,home treatment ,economic ,efficacy ,acute mental healthcare ,home visits ,Intervention (counseling) ,medicine ,Protocol ,community-based ,risk ,Service (business) ,Home visit ,business.industry ,Mental health service ,Public health ,public health ,General Medicine ,home ,mental health services ,Focus group ,Mental health ,Gatekeeping ,accessibility ,crisis ,Crisi ,Family medicine ,Economic evaluation ,crisis resolution ,business ,home care ,risks ,mental health ,Qualitative research - Abstract
Background Crisis Resolution and Home Treatment (CRHT) teams represent a community-based mental health service offering a valid alternative to hospitalization. CRHT teams have been widely implemented in various mental health systems worldwide, and their goal is to provide care for people with severe acute mental disorders who would be considered for admission to acute psychiatric wards. The evaluation of several home-treatment experiences shows promising results; however, it remains unclear which specific elements and characteristics of CRHT are more effective and acceptable. Objective This study aims to assess the acceptability, effectiveness, and cost-effectiveness of a new CRHT intervention in Ticino, Southern Switzerland. Methods This study includes an interventional, nonrandomized, quasi-experimental study combined with a qualitative study and an economic evaluation to be conducted over a 48-month period. The quasi-experimental evaluation involves two groups: patients in the northern area of the region who were offered the CRHT service (ie, intervention group) and patients in the southern area of the region who received care as usual (ie, control group). Individual interviews will be conducted with patients receiving the home treatment intervention and their family members. CRHT members will also be asked to participate in a focus group. The economic evaluation will include a cost-effectiveness analysis. Results The project is funded by the Swiss National Science Foundation as part of the National Research Program NRP74 for a period of 48 months starting from January 2017. As of October 2021, data for the nonrandomized, quasi-experimental study and the qualitative study have been collected, and the results are expected to be published by the end of the year. Data are currently being collected for the economic evaluation. Conclusions Compared to other Swiss CRHT experiences, the CRHT intervention in Ticino represents a unique case, as the introduction of the service is backed by the closing of one of its acute wards. The proposed study will address several areas where there are evidence gaps or contradictory findings relating to the home treatment of acute mental crisis. Findings from this study will allow local services to improve their effectiveness in a challenging domain of public health and contribute to improving access to more effective care for people with severe mental disorders. Trial Registration ISRCTN registry ISRCTN38472626; https://www.isrctn.com/ISRCTN38472626 International Registered Report Identifier (IRRID) DERR1-10.2196/28191
- Published
- 2021
8. Impulsivity and Gambling Type Among Treatment-Seeking Disordered Gamblers: An Explorative Study
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Henrietta Bowden-Jones, Massimo Clerici, Alex Blaszczynski, Vittorio Lutri, Emiliano Soldini, S. Ronzitti, Neil Smith, Lutri, V, Soldini, E, Ronzitti, S, Smith, N, Clerici, M, Blaszczynski, A, and Bowden-Jones, H
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Male ,Psychology (all) ,Multivariate analysis ,Sociology and Political Science ,Gambling machine ,BIS-11 ,Electronic gambling ,Motor impulsivity ,Logistic regression ,Choice Behavior ,Problem gambling ,0302 clinical medicine ,Surveys and Questionnaires ,Surveys and Questionnaire ,Situational ethics ,General Psychology ,Pathological gambling ,education.field_of_study ,Middle Aged ,Type of gambling ,Female ,medicine.symptom ,Psychology ,Human ,Clinical psychology ,Adult ,Impulsivity ,Adolescent ,Logistic Model ,Gambling activitie ,Population ,Exploratory research ,Gambling type ,Gambling disorder ,Young Adult ,03 medical and health sciences ,medicine ,Humans ,Psychological testing ,UPPS-P ,education ,Barrat impulsivity scale ,Aged ,Psychological Tests ,Negative urgency ,030227 psychiatry ,Behavior, Addictive ,Psychological Test ,Psychotherapy ,Logistic Models ,Gambling ,Impulsive Behavior ,Structured interview ,030217 neurology & neurosurgery - Abstract
Several studies have found that certain traits of impulsivity are associated with gambling disorder, and influence its severity. Furthermore, it has been suggested that some forms of gambling, particularly electronic gambling machines, are particularly widespread among pathological gamblers. In the present, exploratory study, we aim to clarify the role played by impulsivity in influencing the choice of specific gambling activities, by examining the relation between individual dimensions of impulsivity, and the choice of specific gambling activities in a clinical population. 100 consecutively admitted pathological gamblers at the National Problem Gambling Clinic in London (UK) in 2014 were administered the UPPS-P and BIS-11 impulsivity questionnaires, the Problem Gambling Severity Index, and underwent a structured interview concerning their gambling activities in the month and year prior to assessment. The correlation between individual gambling activities and impulsivity dimensions was analyzed both at a bivariate level, and using logistic regression. We found a significant correlation between Negative Urgency, Motor impulsivity and low-stakes machine gambling on multivariate analysis. Negative urgency (i.e. the tendency to act impulsively in response to negative affect), and Motor impulsivity (a tendency to rash action and restlessness) might be mediating factors in the choice of electronic gambling machines, particularly among patients whose gambling is escape-oriented. Structural and situational characteristics of gambling machines, particularly the widespread availability of low-stakes-rather than high-stakes-gaming machines, might concur to the choice of this form of gambling among individuals who present higher negative urgency and restlessness.
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- 2018
9. Types of gambling and levels of harm: A UK study to assess severity of presentation in a treatment-seeking population
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Henrietta Bowden-Jones, Vittorio Lutri, S. Ronzitti, Neil Smith, Emiliano Soldini, Massimo Clerici, Ronzitti, S, Soldini, E, Lutri, V, Smith, N, Clerici, M, and Bowden-Jones, H
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Adult ,Male ,medicine.medical_specialty ,Full-Length Report ,media_common.quotation_subject ,Population ,030508 substance abuse ,Medicine (miscellaneous) ,Bivariate analysis ,type of gambling ,Disease cluster ,involvement ,Severity of Illness Index ,03 medical and health sciences ,0302 clinical medicine ,Severity of illness ,Interview, Psychological ,London ,medicine ,Cluster Analysis ,Humans ,Psychiatry ,education ,media_common ,education.field_of_study ,Cluster Analysi ,Addiction ,pathological gambling ,Linear model ,gambling disorder ,General Medicine ,Patient Acceptance of Health Care ,030227 psychiatry ,Test (assessment) ,Behavior, Addictive ,Clinical Psychology ,Harm ,Psychiatry and Mental Health ,Gambling ,Linear Models ,Linear Model ,Female ,0305 other medical science ,Psychology ,Clinical psychology ,Human ,harm - Abstract
Background and aim: Previous international research emphasized that some forms of gambling are more "addictive" than others. More recently, research has shown that we should shift our attention fromthe type of gambling activity to the level of involvement in a number of different gambling activities. The aim of our study was to verify whether a higher Problem Gambling Severity Index (PGSI) score was associated with particular gambling activities and evaluate the impact of involvement on gambling behavior. Methods: A total of 736 treatment-seeking individuals with gambling disorder were assessed at the National Problem Gambling Clinic in London. First, the independent two-sample t-test and the Mann-Whitney test were used to verify if the PGSI score changed significantly according to the gambling activity at a bivariate level. Second, we conducted a cluster analysis and finally, we fitted a linear regression model in order to verify if some variables are useful to predict gambling addiction severity. Results: The PGSI score was significantly higher for lower stakes gaming machine gamblers (1% significance level) and for fixed-odds betting terminal (FOBT) gamblers (5% significance level) at a bivariate level. Moreover, such finding was confirmed by cluster and linear regression analyses. Conclusions: The results of this study indicated that gambling addiction severity was related to gambling involvement and, for a given level of gambling involvement, gambling addiction severity may vary according to gambling type, with a particularly significant increase for FOBT and gaming machine gambling.
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- 2016
10. Are Treatment Outcomes Determined by Type of Gambling? A UK Study
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Neil Smith, Henrietta Bowden-Jones, S. Ronzitti, Massimo Clerici, Emiliano Soldini, Andrew Bayston, Ronzitti, S, Soldini, E, Smith, N, Bayston, A, Clerici, M, and Bowden-Jones, H
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Adult ,Male ,Psychology (all) ,Logistic Model ,Sociology and Political Science ,Adolescent ,Treatment outcome ,Population ,030508 substance abuse ,Sample (statistics) ,Gambling disorder ,Compliance (psychology) ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Multinomial logistic regression model ,London ,Humans ,Young adult ,education ,General Psychology ,Psychological treatment ,education.field_of_study ,Pathological gambling ,Dropout ,030227 psychiatry ,Type of gambling ,Behavior, Addictive ,Logistic Models ,Treatment Outcome ,Gambling ,Female ,Self Report ,0305 other medical science ,Psychology ,Clinical psychology ,Human - Abstract
One of the main difficulties faced in treating gambling disorder is compliance with psychological treatment. Gambling takes many forms and can differ greatly in its features such as speed of play and skill requirements. The type of gambling a pathological gambler opts for may play a key role in treatment compliance. The aim of the present study was to determine whether within treatment seeking sample of gambling disorder clients, gambling activity has any correlation with their resultant treatment outcomes. The study incorporated 524 treatment-seeking individuals who are clients of the National Problem Gambling Clinic in London. All of the clients were assessed prior to treatment and fulfilled the Problem Gambling Severity Index criteria for problem gambling. Data concerning clients' gambling behavior over the previous year was gathered using self-reports. Subsequently, the data was fitted to a multinomial logistic regression model, with the treatment outcome (i.e. pre-treatment dropouts, during treatment dropouts, and completed treatment) as the dependent variable and gambling behavior as the independent variable, whilst controlling for socio-demographic factors. The use of gaming machines was a significant predictor of dropping out pre-treatment (p
- Published
- 2018
11. Gambling Disorder: Exploring Pre-treatment and In-treatment Dropout Predictors. A UK Study
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Henrietta Bowden-Jones, Emiliano Soldini, Neil Smith, Massimo Clerici, S. Ronzitti, Ronzitti, S, Soldini, E, Smith, N, Clerici, M, and Bowden-Jones, H
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Pre treatment ,Adult ,Male ,050103 clinical psychology ,medicine.medical_specialty ,Younger age ,Patient Dropouts ,Sociology and Political Science ,education ,Dropout (communications) ,Treatment dropout ,Gambling disorder ,behavioral disciplines and activities ,03 medical and health sciences ,0302 clinical medicine ,Multinomial logistic regression model ,health services administration ,Surveys and Questionnaires ,medicine ,Humans ,0501 psychology and cognitive sciences ,Treatment outcome ,Family history ,Psychiatry ,Pathological ,health care economics and organizations ,General Psychology ,Pathological gambling ,05 social sciences ,Middle Aged ,United Kingdom ,030227 psychiatry ,Behavior, Addictive ,Logistic Models ,Dropout predictor ,Gambling ,population characteristics ,Female ,Self Report ,Psychology ,Clinical psychology - Abstract
The aim of this study was to identify predictors of treatment dropout in a sample of gamblers attending a specialist clinic for gambling disorder. We analysed data on 846 treatment-seeking pathological gamblers. Firstly, we investigated differences in socio-demographic and clinical variables between treatment completers and pre-treatment dropouts, as well as between treatment completers and during-treatment dropouts. Subsequently, variables were entered into a multinomial logistic regression model to identify significant predictors of pre-treatment and in-treatment dropout. Overall, 44.8% of clients did not complete the treatment: 27.4% dropped out before starting it, while 17.4% dropped out during the treatment. Younger age and use of drugs were associated with pre-treatment dropout, while family history of gambling disorder, a lower PGSI score, and being a smoker were related with in-treatment dropout. Our findings suggest that pre-treatment dropouts differ from in-treatment dropouts, and, thus, further research will benefit from considering these groups separately. In addition, this newly gained knowledge will also be helpful in increasing treatment retention in specific subgroups of problem gamblers.
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- 2017
12. Current suicidal ideation in treatment-seeking individuals in the United Kingdom with gambling problems
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Marc N. Potenza, Neil Smith, Massimo Clerici, S. Ronzitti, Emiliano Soldini, Henrietta Bowden-Jones, Ronzitti, S, Soldini, E, Smith, N, Potenza, M, Clerici, M, and Bowden-Jones, H
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Adult ,Male ,medicine.medical_specialty ,Lifetime prevalence ,030508 substance abuse ,Medicine (miscellaneous) ,Clinical settings ,Sex Factor ,Anxiety ,Gambling disorder ,Logistic regression ,Suicidality ,Toxicology ,Severity of Illness Index ,Suicidal Ideation ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,medicine ,Humans ,Psychiatry ,Attempt suicide ,Suicidal ideation ,Pathological ,Pathological gambling ,Treatment seeking ,Cognitive Behavioral Therapy ,Patient Acceptance of Health Care ,medicine.disease ,United Kingdom ,030227 psychiatry ,Behavior, Addictive ,Suicide ,Clinical Psychology ,Psychiatry and Mental Health ,Gambling ,Female ,medicine.symptom ,0305 other medical science ,Psychology ,Predictive factor ,Anxiety disorder ,Clinical psychology ,Human - Abstract
Background Studies show higher lifetime prevalence of suicidality in individuals with pathological gambling. However, less is known about the relationship between pathological gambling and current suicidal ideation. Objectives We investigated socio-demographic, clinical and gambling-related variables associated with suicidality in treatment-seeking individuals. Methods Bivariate analyses and logistic regression models were generated on data from 903 individuals to identify measures associated with aspects of suicidality. Results Forty-six percent of patients reported current suicidal ideation. People with current suicidal thoughts were more likely to report greater problem-gambling severity (p < 0.001), depression (p < 0.001) and anxiety (p < 0.001) compared to those without suicidality. Logistic regression models suggested that past suicidal ideation (p < 0.001) and higher anxiety (p < 0.05) may be predictive factors of current suicidality. Conclusions Our findings suggest that the severity of anxiety disorder, along with a lifetime history of suicidal ideation, may help to identify treatment-seeking individuals with pathological gambling with a higher risk of suicidality, highlighting the importance of assessing suicidal ideation in clinical settings.
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- 2017
13. Maximal Oxygen Consumption Is Negatively Associated with Fat Mass in Facioscapulohumeral Dystrophy.
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Crisafulli O, Grattarola L, Bottoni G, Lacetera J, Lavaselli E, Beretta-Piccoli M, Tupler R, Soldini E, and D'Antona G
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- Humans, Male, Female, Adult, Middle Aged, Body Composition, Body Mass Index, Adipose Tissue metabolism, Young Adult, Exercise Test, Muscular Dystrophy, Facioscapulohumeral physiopathology, Oxygen Consumption
- Abstract
Facioscapulohumeral dystrophy (FSHD) leads to progressive changes in body composition such as loss of muscle mass and increase in adiposity. In healthy subjects, anthropometric parameters are associated with the maximum volume of oxygen consumed per minute (VO
2 max), which is a health and function indicator in several populations of subjects, both healthy and pathological. Since VO2 max can be difficult to test in patients with FSHD due to exercise intolerance, the identification of associated anthropometric parameters could provide new easily obtainable elements for the patients' clinical stratification. The aim of this study was to evaluate whether anthropometric and body composition parameters are associated with VO2 max in patients with FSHD. A total of 22 subjects with a molecular genetics-based diagnosis of FSHD (6 females, 16 males, mean age of 35.18 years) were recruited for the study. VO2 max was measured by cardiopulmonary exercise tests (CPETs) on a cycle ergometer, utilizing a step incremental technique (15 Watts (W) every 30 s). Weight (Kg) and height (m) were obtained and utilized to calculate body mass index (BMI). Body composition parameters (fat mass (FM), fat free mass (FFM), and body cell mass (BCM)) were obtained by bioelectrical impedance analysis (BIA). Significant negative associations were found between VO2 max and FM (Spearman correlation coefficient (SCC) -0.712), BMI (SCC -0.673), age (SCC -0.480), and weight (SCC -0.634), unlike FFM and BCM. Our results indicate that FM, BMI, age, and body weight are negatively associated with VO2 max in patients with FSHD. This evidence may help practitioners to better stratify patients with FSHD.- Published
- 2024
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14. Reporting the Location and Extent of Pain in Adolescents: A Test-Retest Reliability Study.
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Folli A, Falla D, Cescon C, Vanoni F, Soldini E, and Barbero M
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- Humans, Adolescent, Reproducibility of Results, Female, Child, Male, Surveys and Questionnaires, Pain Measurement methods, Musculoskeletal Pain diagnosis
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Background: A pain drawing is a self-administered assessment that requires the patient to shade in on a body chart the areas in which he or she experiences pain, regardless of the intensity. Pain drawings have already been validated in several adult populations., Objectives: The aim of this study is to establish adolescents' test-retest reliability in reporting the extent and location of their pain using a paper-based pain drawing., Study Design: A one-day test-retest reliability study was set up., Setting: The study took place in 2 separate locations-a pediatric hospital and a private physiotherapy practice in Ticino, in the southern part of Switzerland. This reliability study was approved by the local ethics committee of Ticino (2021-00492 CE 3832)., Methods: Adolescents with musculoskeletal pain (aged 11-16 years) were included. All participants were asked to shade the areas in which they experienced pain over the previous week. After the administration of a questionnaire and the acquisition of further personal data, the pain drawing was administered again. The pain drawings were then scanned and analyzed using a digital platform, which allowed the extraction of pain extent and location values. The test-retest reliability was evaluated on these data. The intraclass correlation coefficient and Bland-Altman analysis were used to assess the reliability of the reporting of the pain extent, whereas the Jaccard similarity coefficient was used to calculate the reliability of the reporting of the pain location., Results: The reporting of the pain extent was observed to have excellent test-retest reliability: ICC2,1: 0.959 (95% CI: 0.925-0.978). The Bland-Altman analysis showed a mean difference close to 0: -0.010% (limits of agreements -0.962 to 0.942). The reliability of the reporting of pain location was also supported by the Jaccard index mean score of 0.82 (± 0.19)., Limitations: Reliability of reporting may vary depending on the nature of the pain, its duration, or the type of disorder and body areas involved., Conclusions: Adolescents complaining musculoskeletal pain showed reliability in reporting pain extent and location using pain drawings.
- Published
- 2024
15. Factors associated with increased risk of playing-related disorders among classical music students within the Risk of Music Students (RISMUS) longitudinal study.
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Cruder C, Soldini E, Gleeson N, and Barbero M
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- Humans, Longitudinal Studies, Surveys and Questionnaires, Risk Factors, Students psychology, Music, Occupational Diseases epidemiology, Musculoskeletal Diseases epidemiology
- Abstract
Playing-related musculoskeletal disorders (PRMDs) are common among musicians but longitudinal data on risk factors are limited. The aim of the study was to longitudinally identify the factors associated with increased risk of PRMD onset among music students enrolled in different pan-European music institutions. A further goal was to assess the occurrence of PRMDs during a 12-month period. A total of 442 students without PRMDs from 56 European music universities completed a web-based questionnaire on lifestyle and practice habits, health history, physical activity, psychological distress, perfectionism, and fatigue. PRMD onset was assessed prospectively at 6 and 12 months. Logistic regression analysis showed that changes in physical activity level (6-month AOR = 2.343, 12-month AOR = 2.346), increased levels of fatigue (6-month AOR = 1.084, 12-month AOR = 1.081) and socially-prescribed perfectionism (6-month AOR = 1.102) were significantly associated with PRMD onset, which had occurred in 49% of participants during 12 months. Musculoskeletal complaints reported at baseline (6-month AOR = 0.145, 12-month AOR = 0.441) and changes to BMI (12-month AOR = 0.663) limited the onset of PRMDs. The study's novel longitudinal findings were appraised critically within the contexts of potential factors for PRMD onset and evidence-based preventive strategies to minimise the impact of PRMDs., (© 2023. The Author(s).)
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- 2023
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16. Age at initial diagnosis of autism spectrum disorders: a retrospective comparison of screening techniques between the southern and northwestern regions of Switzerland.
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Sommer M, Glaser B, Soldini E, Weber P, and Ramelli GP
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- Infant, Humans, Child, Adolescent, Switzerland, Sensitivity and Specificity, Retrospective Studies, Mass Screening methods, Checklist, Autism Spectrum Disorder diagnosis
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Aims: Early diagnosis of autism spectrum disorders (ASD) offers the possibility of early intervention and, in turn, gains in adaptive behaviour, language and cognition. The aim of the present study was to analyse whether age at diagnosis of autism spectrum disorders decreased in two regions of Switzerland from 2006 to 2016 following the implementation of different screening and referral techniques. In southern Switzerland, systematic paediatric screening using the Modified Checklist for Autism (M-CHAT) in toddlers was implemented in 2013, whereas in northwestern Switzerland, periodic trainings were used to increase paediatrician awareness of ASD. We investigated which method was associated with a younger average age at diagnosis., Methods: We conducted a retrospective, two-centre study searching clinical records of children and adolescents (aged 0-16 years) diagnosed with ASD in two neuropaediatric departments at Swiss hospitals between January 2006 and December 2016. All patients were diagnosed via a standardised evaluation based on two approved diagnostic tests: the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) and the Autism Diagnostic Interview-Revised (ADI-R)., Results: In southern Switzerland, training and subsequent widespread use of the M-CHAT among paediatricians appeared to contribute to a significantly younger age at diagnosis. Age at diagnosis did not significantly decrease during the same period in northwestern Switzerland., Conclusion: Our results point to the possibility of successfully reducing age at diagnosis in specific geographic areas through the implementation of screening questionnaires, such as the M-CHAT, at year 2 well-baby visits.
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- 2023
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17. Shear Wave Tensiometry Can Detect Loading Differences Between Operated and Unaffected Achilles Tendon.
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Schneebeli A, Barbero M, Filardo G, Testa E, Riegger M, Sangiorgio A, Cescon C, Soldini E, and Falla D
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- Humans, Case-Control Studies, Cross-Sectional Studies, Ankle, Ultrasonography, Rupture surgery, Achilles Tendon surgery, Achilles Tendon diagnostic imaging, Tendon Injuries diagnostic imaging, Tendon Injuries surgery
- Abstract
Background: The clinically relevant healing process of a ruptured and repaired Achilles tendon (AT) can last more than a year. The purpose of this cross-sectional study was to test if shear wave tensiometry is able to detect AT loading changes between a surgically managed AT rupture versus the unaffected contralateral tendon. Our secondary aims were to evaluate differences in mechanical properties when measured with myotonometry and morphological properties of the tendons measured with ultrasonographic imaging., Methods: Twenty-one patients with surgically treated AT ruptures were investigated 12-37 months after surgery. Tendon load was measured using a shear wave tensiometer composed of an array of 4 accelerometers fixed on the tendon. Shear wave speed along the Achilles tendon was evaluated at different levels of ankle torque for both the operated and the unaffected side. Mechanical properties of the tendons were evaluated using MyotonPRO and morphological properties using ultrasonographic imaging. Friedman test was used to assess differences in AT wave speed, stiffness, thickness, and cross-sectional area between the operated and the unaffected tendon., Results: We found a significant shear wave speed difference between sides at every ankle joint torque ( P < .05) with a large effect size for the lowest ankle torque and small to medium effect sizes for higher ankle torque. Stiffness, thickness, and cross-sectional area of the operated tendon remained significantly higher compared to the unaffected side., Conclusion: In this cohort, we found that shear wave tensiometry can detect differences between operated and unaffected AT during a standardized loading procedure. The shear wave speed along the operated tendon, as well as the mechanical and morphologic properties, remains higher for 1-3 years after a rupture., Level of Evidence: Level III, case-control study., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. ICMJE forms for all authors are available online.
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- 2023
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18. Sensing the (digital) pulse. Future steps for improving the secondary use of data for research in Switzerland.
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Martani A, Geneviève LD, Wangmo T, Maurer J, Crameri K, Erard F, Spoendlin J, Pauli-Magnus C, Pittet V, Sengstag T, Soldini E, Hirschel B, Borisch B, Kruschel Weber C, Zwahlen M, and Elger BS
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Introduction: Ensuring that the health data infrastructure and governance permits an efficient secondary use of data for research is a policy priority for many countries. Switzerland is no exception and many initiatives have been launched to improve its health data landscape. The country now stands at an important crossroad, debating the right way forward. We aimed to explore which specific elements of data governance can facilitate - from ethico-legal and socio-cultural perspectives - the sharing and reuse of data for research purposes in Switzerland., Methods: A modified Delphi methodology was used to collect and structure input from a panel of experts via successive rounds of mediated interaction on the topic of health data governance in Switzerland., Results: First, we suggested techniques to facilitate data sharing practices, especially when data are shared between researchers or from healthcare institutions to researchers. Second, we identified ways to improve the interaction between data protection law and the reuse of data for research, and the ways of implementing informed consent in this context. Third, we put forth ideas on policy changes, such as the steps necessary to improve coordination between different actors of the data landscape and to win the defensive and risk-adverse attitudes widespread when it comes to health data., Conclusions: After having engaged with these topics, we highlighted the importance of focusing on non-technical aspects to improve the data-readiness of a country (e.g., attitudes of stakeholders involved) and of having a pro-active debate between the different institutional actors, ethico-legal experts and society at large., (© The Author(s) 2023.)
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- 2023
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19. Attentive-executive functioning and compensatory strategies in adult ADHD: A retrospective case series study.
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Ceroni M, Rossi S, Zerboni G, Biglia E, Soldini E, Izzo A, Morellini L, and Sacco L
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Background: Adults with ADHD exhibit a neuropsychological profile that may present deficits in many cognitive domains, particularly attention and executive functions (EFs). However, some authors do not consider executive disfunction as an important part of the clinical profile of the syndrome; this could be related to the use of inappropriate neuropsychological tests, probably not adapted and not sufficiently ecological. Moreover, new data are required on specific correlation of attentive-executive symptoms with socio-demographic factors. Therefore, the aim of this study is to analyze the neuropsychological performance of a group of adults with ADHD, also evaluating the influence of gender, age and education level., Methods: We retrospectively collected health-related personal data of 40 adult ADHD patients, clinically diagnosed and evaluated via a battery of 4 neuropsychological tests and 1 self-administered questionnaire. Gender, age and years of education differences were assessed., Results: Attention and EFs deficits have been highlighted mainly on the d2-R and 5-point neuropsychological tests, which therefore seem to be more sensitive in measuring the attention-executive dysfunction in an adult ADHD population, than TAP Go/No-go and ROCFT. ADHD patients also manifested subjective behavioral impulsivity disorders on BIS-11. There were no statistically significant gender differences in cognitive performance. On the contrary, younger patients performed worse on subscales TAP Go/No-go errors and 5-points number of drawings, while participants with a higher education level performed better on subscales d2-R speed of execution and d2-R errors. This supports a reduction in the number of errors and the execution time as a function of older age and a higher level of education. Finally, patients with higher education also self-reported greater impulsivity in planning., Conclusion: Our preliminary findings suggest that adult ADHD is not a lifelong stable disorder, but it may change over time. Moreover, attention-executive deficits may be influenced and partially counterbalanced by experience (i.e., advancing age) and a higher level of education. This could underlie the development of specific psycho-behavioral and cognitive compensatory strategies. The use of self-administered questionnaires is therefore recommended to highlight attentional and executive difficulties that may not result in neuropsychological tests., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Ceroni, Rossi, Zerboni, Biglia, Soldini, Izzo, Morellini and Sacco.)
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- 2022
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20. Effectiveness of crisis resolution home treatment for the management of acute psychiatric crises in Southern Switzerland: a natural experiment based on geography.
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Soldini E, Alippi M, Zufferey MC, Lisi A, Lucchini M, Albanese E, Colombo RA, Rossa S, Bolla E, Mellacqua ZB, Larghi G, Cordasco S, Kawohl W, Crivelli L, and Traber R
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- Caregivers, Geography, Hospitalization, Humans, Switzerland, Mental Disorders therapy
- Abstract
Background: Crisis Resolution Home Treatment (CRHT) is an alternative to inpatient treatment for acute psychiatric crises management. However, evidence on CRHT effectiveness is still limited. In the Canton of Ticino (Southern Switzerland), in 2016 the regional public psychiatric hospital replaced one acute ward with a CRHT. The current study was designed within this evaluation setting to assess the effectiveness of CRHT compared to standard inpatient treatment., Methods: CRHT was offered to patients aged 18 to 65 with an acute psychiatric crisis that would have required hospitalization. We used a natural experiment based on geography, where intervention and control groups were formed according to the place of residence. Primary endpoints were reduction of psychiatric symptoms at discharge measured using the Health of the Nation Outcome Scales, treatment duration in days, and rate and length of readmissions during a two-year follow-up period after discharge. Safety during the treatment period was measured with the number of serious adverse events (suicide/suicide attempts, major self-harm episodes, acute alcohol/drug intoxications, aggressions to caregivers or family members). We used linear, log-linear and logistic regression models with propensity scores for the main analysis., Results: We enrolled 321 patients; 67 were excluded because the treatment period was too short and 17 because they were transferred before the end of the treatment. Two hundred thirty-seven patients were available for data analysis, 93 in the intervention group and 144 in the control group. No serious adverse event was observed during the treatment period in both groups. Reduction of psychiatric symptoms at discharge (p-value = 0.359), readmission rates (p-value = 0.563) and length of readmissions (p-value = 0.770) during the two-year follow-up period did not differ significantly between the two groups. Treatment duration was significantly higher in the treatment group (+ 29.6% on average, p-value = 0.002)., Conclusions: CRHT was comparable to standard hospitalization in terms of psychiatric symptoms reduction, readmission rates and length of readmissions, but it was also characterized by a longer first treatment period. However, observational evidence following the study indicated that CRHT duration constantly lowered over time since its introduction in 2016 and became comparable to hospitalization, showing therefore to be an effective alternative also in terms of treatment length., Trial Registration: ISRCTN38472626 (17/11/2020, retrospectively registered)., (© 2022. The Author(s).)
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- 2022
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21. Home Treatment for Acute Mental Health Care: Protocol for the Financial Outputs, Risks, Efficacy, Satisfaction Index and Gatekeeping of Home Treatment (FORESIGHT) Study.
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Levati S, Mellacqua Z, Caiata-Zufferey M, Soldini E, Albanese E, Alippi M, Bolla E, Colombo RA, Cordasco S, Kawohl W, Larghi G, Lisi A, Lucchini M, Rossa S, Traber R, and Crivelli L
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Background: Crisis Resolution and Home Treatment (CRHT) teams represent a community-based mental health service offering a valid alternative to hospitalization. CRHT teams have been widely implemented in various mental health systems worldwide, and their goal is to provide care for people with severe acute mental disorders who would be considered for admission to acute psychiatric wards. The evaluation of several home-treatment experiences shows promising results; however, it remains unclear which specific elements and characteristics of CRHT are more effective and acceptable., Objective: This study aims to assess the acceptability, effectiveness, and cost-effectiveness of a new CRHT intervention in Ticino, Southern Switzerland., Methods: This study includes an interventional, nonrandomized, quasi-experimental study combined with a qualitative study and an economic evaluation to be conducted over a 48-month period. The quasi-experimental evaluation involves two groups: patients in the northern area of the region who were offered the CRHT service (ie, intervention group) and patients in the southern area of the region who received care as usual (ie, control group). Individual interviews will be conducted with patients receiving the home treatment intervention and their family members. CRHT members will also be asked to participate in a focus group. The economic evaluation will include a cost-effectiveness analysis., Results: The project is funded by the Swiss National Science Foundation as part of the National Research Program NRP74 for a period of 48 months starting from January 2017. As of October 2021, data for the nonrandomized, quasi-experimental study and the qualitative study have been collected, and the results are expected to be published by the end of the year. Data are currently being collected for the economic evaluation., Conclusions: Compared to other Swiss CRHT experiences, the CRHT intervention in Ticino represents a unique case, as the introduction of the service is backed by the closing of one of its acute wards. The proposed study will address several areas where there are evidence gaps or contradictory findings relating to the home treatment of acute mental crisis. Findings from this study will allow local services to improve their effectiveness in a challenging domain of public health and contribute to improving access to more effective care for people with severe mental disorders., Trial Registration: ISRCTN registry ISRCTN38472626; https://www.isrctn.com/ISRCTN38472626., International Registered Report Identifier (irrid): DERR1-10.2196/28191., (©Sara Levati, Zefiro Mellacqua, Maria Caiata-Zufferey, Emiliano Soldini, Emiliano Albanese, Maddalena Alippi, Emilio Bolla, Raffaella Ada Colombo, Severino Cordasco, Wolfram Kawohl, Giuseppina Larghi, Angela Lisi, Mario Lucchini, Simona Rossa, Rafael Traber, Luca Crivelli. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 09.11.2021.)
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- 2021
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22. [Description and analysis of disease representation in chronic patients through the Illness Perception Questionnaire (IPQ-r): implications for clinical practice].
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Giuffrida S, Fiala S, Barro L, Pazzi S, Soldini E, Levati S, Prandi C, Bianchi M, and D'Angelo V
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- Humans, Pilot Projects, Psychometrics, Surveys and Questionnaires, Emotions, Perception
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Introduction: According to the theory of Self-Regulation, the individual develops self-regulation processes that guide the course of pathology through mental representations of disease. These should be an essential part of nursing in developing the patient's motivation and self-efficacy, and the Illness Perception Questionnaire allows us to understand the construction processes., Aim: The aim is to analyze the mental representations of illness of a group of chronically ill patients, to evaluate the implications in therapeutic adherence and clinical practice., Methods: Pilot study conducted on a sample of 89 chronically ill patients through the Illness Perception Questionnaire., Results: By correlating the illness dimensions of the Self-Regulation, the significant relationship between emotional representations and the other dimensions emerges. Negative emotions lead the individual to perceive more the cyclical duration of the disease, the severity of its consequences, have a lower perception of coherence and understanding of the disease. A greater opinion of personal control corresponds to a lower perception of serious consequences and a greater perception of control of treatment. The prevalence of negative emotions and a lower disease consistency score are highlighted in patients with low educational level., Conclusion: The study demonstrated the adequacy of IPQ-r in detecting disease representations, which can affect outcomes in treatment. Above all, the importance of the emotional dimension related to the perception of the disease. The application of IPQ-r can be a valid tool for nurses in detecting the perception of illness of their patients resulting in a useful strategy to promote the educational process and promote adequate therapeutic adherence.
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- 2021
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23. Essential oil therapy for the short-term treatment of behavioral and psychological symptoms of dementia: a monocentric randomized pilot study.
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Mascherona I, Ferretti M, Soldini E, Biggiogero M, Maggioli C, and Fontana PE
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- Aged, Behavioral Symptoms, Caregivers, Humans, Pilot Projects, Psychiatric Status Rating Scales, Dementia drug therapy, Oils, Volatile therapeutic use
- Abstract
Background: The behavioral and psychological symptoms of dementia (BPSD) can be severely distressing for both patients and caregivers., Aims: This study assessed the efficacy of environmental diffusion essential oil therapy (EOT) combined with psychotropic drug therapy (group A) in BPSD management, compared with psychotropic drug therapy alone (group B). The stress responses of attending caregivers were also assessed., Methods: Thirty-two patients with dementia and BPSD were enrolled. The presence and severity of BPSD were assessed using the Italian version of the NPI-NH scale, which also measures the stress felt by professional caregivers. Global geriatric evaluations were performed to rule out acute diseases that could contribute to delirium and worsen patients' mental status., Results: Following treatment, the average NPI-NH value was significantly reduced in group A compared with group B (p < 0.001). Caregiver distress was also significantly reduced in group A (p < 0.01)., Discussion: This pilot study showed that BPSD were better treated using EOT combined with standard pharmacological treatment, compared with standard pharmacological treatment alone. No adverse effects of EOT were observed. Reductions in caregiver distress could be due either to reductions in BPSD severity and frequency resulting in decreased caregiver burden, and/or the emotional benefit for caregivers of exposure to essential oils., Conclusions: This study supports the combined use of EOT and psychotropic drugs in the treatment of BPSD. Essential oils may improve the wellbeing of both patients and caregivers, without adverse effects. Additionally, EOT is easy to administer by environmental diffusion., (© 2020. Springer Nature Switzerland AG.)
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- 2021
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24. Muscle Fiber Conduction Velocity Correlates With the Age at Onset in Mild FSHD Cases.
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Beretta-Piccoli M, Negro M, Calanni L, Berardinelli A, Siciliano G, Tupler R, Soldini E, Cescon C, and D'Antona G
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A majority of patients with facioscapulohumeral muscular dystrophy (FSHD) report severe fatigue. The aim of this study was to explore whether fatigability during a performance task is related to the main clinical features of the disease in mildly affected patients. A total of 19 individuals with a molecular genetic-based diagnosis of FSHD (median D4Z4 deletion length of 27 kb) performed two isometric flexions of the dominant biceps brachii at 20% of their maximal voluntary contraction (MVC) for 2 min, and then at 60% MVC until exhaustion. Fatigability indices (average rectified value, mean frequency, conduction velocity, and fractal dimension) were extracted from the surface electromyogram (sEMG) signal, and their correlations with age, age at onset, disease duration, D4Z4 contraction length, perceived fatigability, and clinical disability score were analyzed. The conduction velocity during the low level contraction showed a significant negative correlation with the age at onset ( p < 0.05). This finding suggest the assessment of conduction velocity at low isometric contraction intensities, as a potential useful tool to highlight differences in muscle involvement in FSHD patients., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Beretta-Piccoli, Negro, Calanni, Berardinelli, Siciliano, Tupler, Soldini, Cescon and D’Antona.)
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- 2021
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25. Increased resistance towards fatigability in patients with facioscapulohumeral muscular dystrophy.
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Beretta-Piccoli M, Calanni L, Negro M, Ricci G, Bettio C, Barbero M, Berardinelli A, Siciliano G, Tupler R, Soldini E, Cescon C, and D'Antona G
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- Adult, Case-Control Studies, Cross-Sectional Studies, Electromyography, Female, Humans, Male, Physical Endurance physiology, Arm physiology, Isometric Contraction physiology, Muscle Fatigue physiology, Muscular Dystrophy, Facioscapulohumeral physiopathology
- Abstract
Purpose: In facioscapulohumeral muscular dystrophy (FSHD) fatigue is a major complaint. We aimed to investigate whether during isometric sustained elbow flexions, performance fatigability indexes differ in patients with FSHD with respect to healthy controls., Methods: Seventeen patients with FSHD and seventeen healthy controls performed two isometric flexions of the dominant biceps brachii at 20% of their maximal voluntary contraction (MVC) for 2 min and then at 60% MVC until exhaustion. Muscle weakness was characterized as a percentage of predicted values. Maximal voluntary strength, endurance time and performance fatigability indices (mean frequency of the power spectrum (MNF), muscle fiber conduction velocity (CV) and fractal dimension (FD)), extracted from the surface electromyogram signal (sEMG) were compared between the two groups., Results: In patients with FSHD, maximal voluntary strength was 68.7% of predicted value (p < 0.01). Compared to healthy controls, FSHD patients showed reduced MVC (p < 0.001; r = 0.62) and lower levels of performance fatigability, characterized by reduced rate of changes in MNF (p < 0.01; r = 0.56), CV (p < 0.05; 0.37) and FD (p < 0.001; r = 0.51) and increased endurance time (p < 0.001; r = 0.63), during the isometric contraction at 60% MVC., Conclusion: A decreased reduction in the slopes of all the considered sEMG parameters during sustained isometric elbow flexions suggests that patients with FSHD experience lower levels of performance fatigability compared to healthy controls.
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- 2021
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26. Correction to: Patterns of pain location in music students: a cluster analysis.
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Cruder C, Barbero M, Soldini E, and Gleeson N
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- 2021
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27. Larger pain extent is associated with greater pain intensity and disability but not with general health status or psychosocial features in patients with cervical radiculopathy.
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Lam K, Peolsson A, Soldini E, Löfgren H, Wibault J, Dedering Å, Öberg B, Zsigmond P, Barbero M, and Falla D
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- Adaptation, Psychological, Adult, Age Factors, Aged, Cervical Vertebrae, Depression etiology, Disabled Persons, Exercise, Female, Humans, Male, Middle Aged, Pain Measurement, Quality of Life, Self Efficacy, Sex Factors, Socioeconomic Factors, Sweden, Work Capacity Evaluation, Young Adult, Disability Evaluation, Health Status, Pain etiology, Pain psychology, Radiculopathy complications
- Abstract
Abstract: Pain as a result of cervical radiculopathy (CR) can be widespread, nondermatomal and individually specific, but the association between pain extent and other clinical features has never been explored. The objective of this study is to investigate whether pain extent relates to clinical variables including pain intensity in addition to health indicators including disability, general health, depression, somatic anxiety, coping strategies or self-efficacy.An observational cohort study was conducted. Participants were recruited from 4 hospital spinal centres in Sweden. Pain extent was quantified from the pain drawings of 190 individuals with cervical disc disease, verified with magnetic resonance imaging (MRI) and compatible with clinical findings (examined by a neurosurgeon), that show cervical nerve root compression. Pain extent was evaluated in relation to neck pain, arm pain, and headache intensity. Multiple linear regression analysis were then used to verify whether pain extent was associated with other health indicators including disability, health-related quality of life, depression, somatic anxiety, coping strategies and self-efficacy.Pain extent was directly related to neck, arm and headache pain intensity (all P < .01). Multiple linear regression revealed that pain extent was significantly associated only to the level of perceived disability (P < .01).Increased pain extent in people with CR is associated with higher headache, neck and arm pain intensity, and disability but not measures of general health, depression, somatic anxiety, coping strategies or self-efficacy., Competing Interests: The authors have no conflicts of interest to declare., (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2021
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28. Patterns of pain location in music students: a cluster analysis.
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Cruder C, Barbero M, Soldini E, and Gleeson N
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- Adult, Cluster Analysis, Female, Humans, Male, Neck Pain, Students, Surveys and Questionnaires, Young Adult, Musculoskeletal Diseases, Musculoskeletal Pain diagnosis, Musculoskeletal Pain epidemiology, Music, Occupational Diseases
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Background: According to existing literature, musicians experience high rates of musculoskeletal (MSK) disorders involving different anatomical areas. The aim of the study was to identify patterns of pain location in a sample of music students enrolled in different pan-European music institutions. A further goal was to explore the association between the identified pain patterns and students' characteristics., Methods: A total of 340 music students (mean age 23.3 years, 66.2% female) with current MSK pain completed a web-based questionnaire including both background information (i.e. lifestyle and physical activity, practice habits) and clinical features (i.e. pain characteristics, disability, pain self-efficacy, psychological distress, perfectionism and fatigue)., Results: Five patterns of pain location were identified by hierarchical cluster analysis: wrist pain (WP) representing 22.6% of the total sample, widespread pain (WSP) (16.9%), right shoulder pain (RSP) (18.5%), both shoulders pain - left concentrated (LSP) (23.2%), neck and back pain (NBP) (18.8%). Amongst the identified patterns of pain location, bivariate analysis identified the WSP cluster as containing the largest number of associated variables. Participants in this cluster reported a higher percentage of women (p < .05), a higher perceived exertion (p < .01) and psychological distress (p < .001), as well as a lower level of self-efficacy (p < .01). Similarly, a higher percentage of participants included in the WSP cluster perceived their musical activity as the main cause of their MSK pain (p < .01). Additionally, a higher level of disability in relation to playing-related activity was reported by participants included in the WP and WSP clusters (p < .001). The RSP cluster was characterised by a higher percentage of participants playing an instrument in a neutral position (p < .001) and lower levels of socially prescribed perfectionism (p < .01). A higher percentage of participants playing an instrument with both arms elevated in the left quadrant position were included in the LSP cluster and a higher percentage of singers were included in the NBP cluster (p < .001)., Conclusions: Five distinct patterns of pain location were identified and their associations with the students' characteristics were explored. These findings may be helpful in the exploration of different aetiologies of MSK pain among musicians and in the development of targeted preventive strategies and treatments.
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- 2021
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29. Prevalence and associated factors of playing-related musculoskeletal disorders among music students in Europe. Baseline findings from the Risk of Music Students (RISMUS) longitudinal multicentre study.
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Cruder C, Barbero M, Koufaki P, Soldini E, and Gleeson N
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- Adolescent, Adult, Europe epidemiology, Female, Humans, Logistic Models, Longitudinal Studies, Male, Middle Aged, Multivariate Analysis, Prevalence, Risk Factors, Self Report, Young Adult, Musculoskeletal Diseases epidemiology, Music
- Abstract
Musculoskeletal (MSK) conditions among professional musicians and music students are frequent and may have significant physical and psychosocial consequences on their lives and/or on their playing abilities. The Risk of Music Students (RISMUS) research project was set up in 2018 to longitudinally identify factors associated with increased risk of playing-related musculoskeletal disorders (PRMDs) in a large sample of music students enrolled in pan-European institutions. The aim of this cross-sectional study was to describe the prevalence of playing-related musculoskeletal disorders (PRMDs) in this novel population at baseline of the RISMUS project. A further goal was to begin to identify variables that might be associated with the self-reported presence of PRMDs among music students. Eight hundred and fifty students from fifty-six conservatories and music universities in Europe completed a web-based questionnaire on lifestyle and physical activity participation levels, musical practice habits, health history and PRMDs, psychological distress, perfectionism and fatigue. A total of 560 (65%) out of 850 participants self-reported a positive history of painful MSK conditions in the last 12 months, 408 (48%) of whom self-reported PRMDs. Results showed that coming from West Europe, being a first- or a second-year Masters student, having more years of experience and higher rates of perceived exertion after 45 minutes of practice without breaks were factors significantly associated with self-reported presence of PRMDs. According to the authors' knowledge, a large-scale multicentre study investigating prevalence and associated factors for PRMDs among music students at different stages of their education (from Pre-college to Masters levels) has not been conducted before. The high prevalence of PRMDs among music students, especially those studying at university-level, has been confirmed in this study and associated factors have been identified, highlighting the need for relevant targeted interventions as well as effective prevention and treatment strategies., Competing Interests: The authors have declared that no competing interests exist.
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- 2020
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30. Electro-mediated drug administration of mitomycin C in preventing non-muscle-invasive bladder cancer recurrence and progression after transurethral resection of the bladder tumour in intermediate- and high-risk patients.
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Carando R, Soldini E, Cotrufo S, Zazzara M, and Ludovico GM
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Objective: To evaluate the effectiveness of electro-mediated drug administration of mitomycin C (EMDA/MMC) after transurethral resection of the bladder tumour (TURBT) in preventing non-muscle-invasive bladder cancer (NMIBC) recurrence and progression and to explore clinical and demographic factors associated with treatment response., Patients and Methods: Between April 2016 and August 2019, 112 patients diagnosed with intermediate- or high-risk NMIBC underwent a TURBT followed by an EMDA/MMC treatment. The percentage of treatment responders and progression-free survivors at 3 and 6 months were evaluated., Results: Follow-up data were available for 101 patients (90%) at 3 months and 92 (82%) at 6 months. Response rates to EMDA/MMC treatment were 85% at 3 months and 75% at 6 months, and progression-free rates were 94% and 90%, respectively. No statistically significant differences were seen between intermediate- and high-risk patients. A higher risk of tumour recurrence and progression was associated with previous Bacillus Calmette-Guérin (BCG) failure. According to the Clavien-Dindo classification, only low-grade complications were observed., Conclusions: EMDA/MMC after TURBT was associated with high response and progression-free rates at 3 and 6 months, with only low-grade adverse events. These results confirm the efficacy and safety of EMDA/MMC as a therapeutic option for both intermediate- and high-risk patients. However, patients with BCG failure responded poorly to EMDA/MMC. Abbreviations : ACCI: age-adjusted Charlson Comorbidity Index; CHT: chemohyperthermia; CIS: carcinoma in situ ; EMDA: electro-mediated drug administration; EORTC: European Organisation for Research and Treatment of Cancer; IQR: interquartile range; (N)MIBC: (non-)muscle-invasive bladder cancer; MMC: mitomycin C; OR, odds ratio; TURBT: transurethral resection of the bladder tumour., Competing Interests: The authors declare that they have no competing interests., (© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
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- 2020
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31. Enhancing Trigger Point Dry Needling Safety by Ultrasound Skin-to-Rib Measurement: An inter-Rater Reliability Study.
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Folli A, Schneebeli A, Ballerini S, Mena F, Soldini E, Fernández-de-Las-Peñas C, and Barbero M
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Dry needling (DN) is a minimally invasive treatment technique widely used by physical therapists to treat myofascial trigger points (MTrP). Even if its safety has been commonly declared and the majority of adverse events are considered mild, serious adverse events cannot be excluded and DN treatments of several trunk muscles can potentially result in pneumothorax. Ultrasound imaging (US) skin-to-rib measurement could ensure the safety of this treatment procedure. Therefore, the aim of this study was to determine the inter-rater reliability of depth measurement of different trunk muscles (i.e., rhomboid, lower trapezius, iliocostalis, and pectoralis major) between an expert and two novice physiotherapists. Skin-to-rib distance of 26 asymptomatic and normal weights subjects was consecutively, independently, and randomly measured for each muscle by the three examiners (1 expert and 2 novice physical therapists) with a handheld US wireless probe. Intraclass correlation coefficient (ICC
3,k ) and standard error of measurement (SEM) were used to assess inter-rater reliability. Inter-rater reliability of skin-to-rib measurements between the three examiners was good to excellent or excellent for every muscle, with an ICC3,k ranging from 0.92 and 0.98 (95% CI 0.86-0.99). The SEM never exceeded 10% of the skin-to-rib distance. In conclusion, skin-to-rib US measurements of the trunk muscles can be reliably performed by novice physical therapists using a handheld US device. These measures could be used as an innovative and reliable technique to improve the safety of some potential dangerous DN treatments.- Published
- 2020
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32. The Extent of Pain Is Associated With Signs of Central Sensitization in Patients With Hip Osteoarthritis.
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Willett MJ, Siebertz M, Petzke F, Erlenwein J, Rushton A, Soldini E, Barbero M, and Falla D
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- Adult, Aged, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Pain psychology, Surveys and Questionnaires, Central Nervous System Sensitization, Osteoarthritis, Hip complications, Pain etiology, Pain Measurement methods
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Background: Central sensitization may be present in some patients with hip osteoarthritis (OA), often reflected as widespread pain. We examine the association between pain extent with signs of central sensitization and other clinical and psychological features in patients with hip OA., Methods: Thirty patients with hip OA were recruited for this cross-sectional observational study. Participants completed pain drawings on a digital tablet, which displayed frontal and dorsal views of the body. The pain extent (%) for each participant was determined by combining the frontal and dorsal pixels shaded and dividing by the total pixels of the body chart area. Participants completed patient-reported outcome measures to assess for signs and symptoms of central sensitization and psychosocial factors. Quantitative sensory testing including pain pressure thresholds (PPTs) and thermal pressure thresholds was performed at points anatomically local and distant from the hip., Results: Women had significantly greater pain extent (6.71%) than men (2.65%) (z = -2.76, P < 0.01). Across all participants, increased pain extent was significantly associated with higher scores on the Widespread Pain Index (r
2 = 0.426, P < 0.05), painDETECT questionnaire (r2 = 0.394, P < 0.05), and Pain Catastrophizing Scale (r2 = 0.413, P < 0.05), and with lower PPTs at the thenar eminence (r2 = -0.410, P < 0.05), vastus lateralis (r2 = -0.530, P < 0.01), vastus medialis (r2 = 0.363, P < 0.05), and greater trochanter (r2 = -0.373, P < 0.05)., Conclusions: Greater pain extent was associated with several measures of signs and symptoms of central sensitization in patients with hip OA. These results support the utility of the pain drawing for identifying signs of central sensitization in patients with hip OA., (© 2019 World Institute of Pain.)- Published
- 2020
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33. Does the Application of Tecar Therapy Affect Temperature and Perfusion of Skin and Muscle Microcirculation? A Pilot Feasibility Study on Healthy Subjects.
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Clijsen R, Leoni D, Schneebeli A, Cescon C, Soldini E, Li L, and Barbero M
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- Adult, Feasibility Studies, Female, Forearm blood supply, Forearm radiation effects, Humans, Laser-Doppler Flowmetry, Male, Middle Aged, Muscle, Skeletal blood supply, Muscle, Skeletal radiation effects, Perfusion Imaging, Pilot Projects, Skin blood supply, Skin radiation effects, Skin Temperature physiology, Skin Temperature radiation effects, Diathermy methods, Electric Stimulation Therapy methods, Microcirculation physiology, Physical Therapy Modalities, Regional Blood Flow physiology
- Abstract
Background: Tecar therapy (TT) is an endogenous thermotherapy used to generate warming up of superficial and deep tissues. TT capability to affect the blood flow is commonly considered to be the primary mechanism to promote tissue healing processes. Despite some preliminary evidence about its clinical efficacy, knowledge on the physiologic responses induced by TT is lacking. Objective: The aim of this quantitative randomized pilot study was to determinate if TT, delivered in two modes (resistive and capacitive), affects the perfusion of the skin microcirculation (PSMC) and intramuscular blood flow (IMBF). Design: A randomized controlled pilot feasibility study. Subjects: Ten healthy volunteers ( n = 4 females, n = 6 males; mean age 35.9 ± 10.7 years) from a university population were recruited and completed the study. Intervention: All subjects received three different TT applications (resistive, capacitive, and placebo) for a period of 8 min. Outcome measures: PSMC, IMBF, and the skin temperature (ST) were measured pre- and post-TT application using power Doppler sonography, laser speckle contrast imaging (LSCI), and infrared thermography. Results: Compared with placebo application, statistically significant differences in PSMC resulted after both the resistive ( p = 0.0001) and the capacitive ( p = 0.0001) TT applications, while only the resistive modality compared with the placebo was capable to induce a significant change of IMBF ( p = 0.013) and ST ( p = 0.0001). Conclusions: The use of power Doppler sonography and LSCI enabled us to evaluate differences in PSMC and IMBF induced by TT application.
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- 2020
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34. Impulsivity and Gambling Type Among Treatment-Seeking Disordered Gamblers: An Explorative Study.
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Lutri V, Soldini E, Ronzitti S, Smith N, Clerici M, Blaszczynski A, and Bowden-Jones H
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- Adolescent, Adult, Aged, Behavior, Addictive therapy, Choice Behavior, Female, Gambling therapy, Humans, Logistic Models, Male, Middle Aged, Psychological Tests, Psychotherapy, Surveys and Questionnaires, Young Adult, Behavior, Addictive psychology, Gambling psychology, Impulsive Behavior
- Abstract
Several studies have found that certain traits of impulsivity are associated with gambling disorder, and influence its severity. Furthermore, it has been suggested that some forms of gambling, particularly electronic gambling machines, are particularly widespread among pathological gamblers. In the present, exploratory study, we aim to clarify the role played by impulsivity in influencing the choice of specific gambling activities, by examining the relation between individual dimensions of impulsivity, and the choice of specific gambling activities in a clinical population. 100 consecutively admitted pathological gamblers at the National Problem Gambling Clinic in London (UK) in 2014 were administered the UPPS-P and BIS-11 impulsivity questionnaires, the Problem Gambling Severity Index, and underwent a structured interview concerning their gambling activities in the month and year prior to assessment. The correlation between individual gambling activities and impulsivity dimensions was analyzed both at a bivariate level, and using logistic regression. We found a significant correlation between Negative Urgency, Motor impulsivity and low-stakes machine gambling on multivariate analysis. Negative urgency (i.e. the tendency to act impulsively in response to negative affect), and Motor impulsivity (a tendency to rash action and restlessness) might be mediating factors in the choice of electronic gambling machines, particularly among patients whose gambling is escape-oriented. Structural and situational characteristics of gambling machines, particularly the widespread availability of low-stakes-rather than high-stakes-gaming machines, might concur to the choice of this form of gambling among individuals who present higher negative urgency and restlessness.
- Published
- 2018
- Full Text
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35. Are Treatment Outcomes Determined by Type of Gambling? A UK Study.
- Author
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Ronzitti S, Soldini E, Smith N, Bayston A, Clerici M, and Bowden-Jones H
- Subjects
- Adolescent, Adult, Behavior, Addictive psychology, Behavior, Addictive therapy, Female, Gambling psychology, Gambling therapy, Humans, Logistic Models, London, Male, Self Report, Treatment Outcome, Young Adult, Behavior, Addictive classification, Gambling classification
- Abstract
One of the main difficulties faced in treating gambling disorder is compliance with psychological treatment. Gambling takes many forms and can differ greatly in its features such as speed of play and skill requirements. The type of gambling a pathological gambler opts for may play a key role in treatment compliance. The aim of the present study was to determine whether within treatment seeking sample of gambling disorder clients, gambling activity has any correlation with their resultant treatment outcomes. The study incorporated 524 treatment-seeking individuals who are clients of the National Problem Gambling Clinic in London. All of the clients were assessed prior to treatment and fulfilled the Problem Gambling Severity Index criteria for problem gambling. Data concerning clients' gambling behavior over the previous year was gathered using self-reports. Subsequently, the data was fitted to a multinomial logistic regression model, with the treatment outcome (i.e. pre-treatment dropouts, during treatment dropouts, and completed treatment) as the dependent variable and gambling behavior as the independent variable, whilst controlling for socio-demographic factors. The use of gaming machines was a significant predictor of dropping out pre-treatment (p < 0.05, RRR 1.616), whilst betting on sports events was a significant predictor of dropping out during treatment (p < 0.01, RRR 2.435). Treatment outcomes have been found to significantly differ based on participation in certain gambling activities. Further research into the salient features of these gambling activities may help to further explain pre-treatment and during treatment dropouts within this population.
- Published
- 2018
- Full Text
- View/download PDF
36. Gambling Disorder: Exploring Pre-treatment and In-treatment Dropout Predictors. A UK Study.
- Author
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Ronzitti S, Soldini E, Smith N, Clerici M, and Bowden-Jones H
- Subjects
- Adult, Female, Humans, Logistic Models, Male, Middle Aged, Self Report, Surveys and Questionnaires, United Kingdom, Behavior, Addictive psychology, Behavior, Addictive therapy, Gambling psychology, Gambling therapy, Patient Dropouts statistics & numerical data
- Abstract
The aim of this study was to identify predictors of treatment dropout in a sample of gamblers attending a specialist clinic for gambling disorder. We analysed data on 846 treatment-seeking pathological gamblers. Firstly, we investigated differences in socio-demographic and clinical variables between treatment completers and pre-treatment dropouts, as well as between treatment completers and during-treatment dropouts. Subsequently, variables were entered into a multinomial logistic regression model to identify significant predictors of pre-treatment and in-treatment dropout. Overall, 44.8% of clients did not complete the treatment: 27.4% dropped out before starting it, while 17.4% dropped out during the treatment. Younger age and use of drugs were associated with pre-treatment dropout, while family history of gambling disorder, a lower PGSI score, and being a smoker were related with in-treatment dropout. Our findings suggest that pre-treatment dropouts differ from in-treatment dropouts, and, thus, further research will benefit from considering these groups separately. In addition, this newly gained knowledge will also be helpful in increasing treatment retention in specific subgroups of problem gamblers.
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- 2017
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- View/download PDF
37. Current suicidal ideation in treatment-seeking individuals in the United Kingdom with gambling problems.
- Author
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Ronzitti S, Soldini E, Smith N, Potenza MN, Clerici M, and Bowden-Jones H
- Subjects
- Adult, Behavior, Addictive psychology, Cognitive Behavioral Therapy, Female, Gambling psychology, Humans, Male, Patient Acceptance of Health Care psychology, Severity of Illness Index, Sex Factors, United Kingdom, Behavior, Addictive complications, Behavior, Addictive therapy, Gambling complications, Gambling therapy, Suicidal Ideation
- Abstract
Background: Studies show higher lifetime prevalence of suicidality in individuals with pathological gambling. However, less is known about the relationship between pathological gambling and current suicidal ideation., Objectives: We investigated socio-demographic, clinical and gambling-related variables associated with suicidality in treatment-seeking individuals., Methods: Bivariate analyses and logistic regression models were generated on data from 903 individuals to identify measures associated with aspects of suicidality., Results: Forty-six percent of patients reported current suicidal ideation. People with current suicidal thoughts were more likely to report greater problem-gambling severity (p<0.001), depression (p<0.001) and anxiety (p<0.001) compared to those without suicidality. Logistic regression models suggested that past suicidal ideation (p<0.001) and higher anxiety (p<0.05) may be predictive factors of current suicidality., Conclusions: Our findings suggest that the severity of anxiety disorder, along with a lifetime history of suicidal ideation, may help to identify treatment-seeking individuals with pathological gambling with a higher risk of suicidality, highlighting the importance of assessing suicidal ideation in clinical settings., (Copyright © 2017 Elsevier Ltd. All rights reserved.)
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- 2017
- Full Text
- View/download PDF
38. Evolution of the methodological quality of controlled clinical trials for myofascial trigger point treatments for the period 1978-2015: A systematic review.
- Author
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Stoop R, Clijsen R, Leoni D, Soldini E, Castellini G, Redaelli V, and Barbero M
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- Forecasting, Humans, Clinical Trials as Topic standards, Electrophysiological Phenomena physiology, Myofascial Pain Syndromes diagnosis, Myofascial Pain Syndromes therapy, Physical Therapy Modalities trends, Trigger Points physiology
- Abstract
Background: The methodological quality of controlled clinical trials (CCTs) of physiotherapeutic treatment modalities for myofascial trigger points (MTrP) has not been investigated yet., Objectives: To detect the methodological quality of CCTs for physiotherapy treatments of MTrPs and demonstrating the possible increase over time., Design: Systematic review., Methods: A systematic search was conducted in two databases, Physiotherapy Evidence Database (PEDro) and Medicine Medical Literature Analysis and Retrieval System online (MEDLINE), using the same keywords and selection procedure corresponding to pre-defined inclusion criteria. The methodological quality, assessed by the 11-item PEDro scale, served as outcome measure. The CCTs had to compare at least two interventions, where one intervention had to lay within the scope of physiotherapy. Participants had to be diagnosed with myofascial pain syndrome or trigger points (active or latent)., Results: A total of n = 230 studies was analysed. The cervico-thoracic region was the most frequently treated body part (n = 143). Electrophysical agent applications was the most frequent intervention. The average methodological quality reached 5.5 on the PEDro scale. A total of n = 6 studies scored the value of 9. The average PEDro score increased by 0.7 points per decade between 1978 and 2015., Conclusions: The average PEDro score of CCTs for MTrP treatments does not reach the cut-off of 6 proposed for moderate to high methodological quality. Nevertheless, a promising trend towards an increase of the average methodological quality of CCTs for MTrPs was recorded. More high-quality CCT studies with thorough research procedures are recommended to enhance methodological quality., (Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2017
- Full Text
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39. Types of gambling and levels of harm: A UK study to assess severity of presentation in a treatment-seeking population.
- Author
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Ronzitti S, Soldini E, Lutri V, Smith N, Clerici M, and Bowden-Jones H
- Subjects
- Adult, Behavior, Addictive psychology, Cluster Analysis, Female, Gambling psychology, Humans, Interview, Psychological, Linear Models, London epidemiology, Male, Severity of Illness Index, Behavior, Addictive epidemiology, Behavior, Addictive therapy, Gambling epidemiology, Gambling therapy, Patient Acceptance of Health Care psychology, Patient Acceptance of Health Care statistics & numerical data
- Abstract
Background and aim Previous international research emphasized that some forms of gambling are more "addictive" than others. More recently, research has shown that we should shift our attention from the type of gambling activity to the level of involvement in a number of different gambling activities. The aim of our study was to verify whether a higher Problem Gambling Severity Index (PGSI) score was associated with particular gambling activities and evaluate the impact of involvement on gambling behavior. Methods A total of 736 treatment-seeking individuals with gambling disorder were assessed at the National Problem Gambling Clinic in London. First, the independent two-sample t-test and the Mann-Whitney test were used to verify if the PGSI score changed significantly according to the gambling activity at a bivariate level. Second, we conducted a cluster analysis and finally, we fitted a linear regression model in order to verify if some variables are useful to predict gambling addiction severity. Results The PGSI score was significantly higher for lower stakes gaming machine gamblers (1% significance level) and for fixed-odds betting terminal (FOBT) gamblers (5% significance level) at a bivariate level. Moreover, such finding was confirmed by cluster and linear regression analyses. Conclusions The results of this study indicated that gambling addiction severity was related to gambling involvement and, for a given level of gambling involvement, gambling addiction severity may vary according to gambling type, with a particularly significant increase for FOBT and gaming machine gambling.
- Published
- 2016
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40. Trumpet mouthpiece manufacturing and tone quality.
- Author
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Zicari M, MacRitchie J, Ghirlanda L, Vanchieri A, Montorfano D, Barbato MC, and Soldini E
- Subjects
- Acoustic Stimulation, Biomechanical Phenomena, Equipment Design, Humans, Male, Motion, Pressure, Sound, Sound Spectrography, Acoustics instrumentation, Copper, Manufactured Materials, Mouth physiology, Music, Pitch Perception, Zinc
- Abstract
This article investigates the relationship between the shape of the mouthpiece and its acoustical properties in brass instruments. The hypothesis is that not only different volumes but also particular cup shapes affect the embouchure and the tone quality in both a physical and perceivable way. Three professional trumpet players were involved, and two different internal cup contours characterized by a "U" and a "V" shape with two types of throat junction (round and sharp) were chosen, based on a Vincent Bach 1 [1/2] C medium mouthpiece. A third intermediate contour was designed as a combination of these. Over 600 sound samples were produced under controlled conditions, the study involving four different stages: (1) Simulation of air-flow, (2) analysis of the sound spectra, (3) study of the players' subjective responses, and (4) perceptual analysis of their timbral differences. Results confirm the U shape is characterized by a stronger air recirculation and produces stronger spectral components above 8 kHz, compared to the V shape. A round throat junction may also be preferable to a sharp one in terms of playability. There is moderate agreement on the aural perception of these differences although the verbal attributes used to qualify these are not shared.
- Published
- 2013
- Full Text
- View/download PDF
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