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273 results on '"Solca, Federica"'

2. Prevalence and motor-functional correlates of frontotemporal-spectrum disorders in a large cohort of non-demented ALS patients

Author

Poletti, Barbara, Aiello, Edoardo Nicolò, Consonni, Monica, Iazzolino, Barbara, Torre, Silvia, Solca, Federica, Faltracco, Veronica, Telesca, Alessandra, Palumbo, Francesca, Dalla Bella, Eleonora, Bersano, Enrica, Riva, Nilo, Verde, Federico, Messina, Stefano, Doretti, Alberto, Maranzano, Alessio, Morelli, Claudia, Calvo, Andrea, Silani, Vincenzo, Lauria, Giuseppe, Chiò, Adriano, and Ticozzi, Nicola

Published
2024
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3. Correction: Clinimetrics and feasibility of the Italian version of the Frontal Assessment Battery (FAB) in non-demented Parkinson’s disease patients

Author

Aiello, Edoardo Nicolò, D’Iorio, Alfonsina, Solca, Federica, Torre, Silvia, Bonetti, Ruggero, Scheveger, Francesco, Colombo, Eleonora, Maranzano, Alessio, Maderna, Luca, Morelli, Claudia, Doretti, Alberto, Amboni, Marianna, Vitale, Carmine, Verde, Federico, Ferrucci, Roberta, Barbieri, Sergio, Zirone, Eleonora, Priori, Alberto, Pravettoni, Gabriella, Santangelo, Gabriella, Silani, Vincenzo, Ticozzi, Nicola, Ciammola, Andrea, and Poletti, Barbara

Published
2024
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4. Reliable change indices for the Italian version of the Montreal Cognitive Assessment (MoCA) in non-demented Parkinson’s disease patients

Author

Aiello, Edoardo Nicolò, Solca, Federica, Torre, Silvia, Curti, Beatrice, De Luca, Giulia, Bonetti, Ruggero, Scheveger, Francesco, Colombo, Eleonora, Maranzano, Alessio, Olivero, Marco, Morelli, Claudia, Doretti, Alberto, Maderna, Luca, Verde, Federico, Ferrucci, Roberta, Barbieri, Sergio, Ruggiero, Fabiana, Mellace, Denise, Marfoli, Angelica, De Sandi, Angelica, Priori, Alberto, Pravettoni, Gabriella, Silani, Vincenzo, Ticozzi, Nicola, Ciammola, Andrea, and Poletti, Barbara

Published
2024
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5. Clinical validity of the Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB) in Mild Cognitive Impairment and Alzheimer’s Disease

Author

Conca, Francesca, Esposito, Valentina, Catricalà, Eleonora, Manenti, Rosa, L’Abbate, Federica, Quaranta, Davide, Giuffrè, Guido Maria, Rossetto, Federica, Solca, Federica, Orso, Beatrice, Inguscio, Emanuela, Crepaldi, Valeria, De Matteis, Maddalena, Rotondo, Emanuela, Manera, Marina, Caruso, Giulia, Catania, Valentina, Canu, Elisa, Rundo, Francesco, Cotta Ramusino, Matteo, Filippi, Massimo, Fundarò, Cira, Piras, Federica, Arighi, Andrea, Tiraboschi, Pietro, Stanzani Maserati, Michelangelo, Pardini, Matteo, Poletti, Barbara, Silani, Vincenzo, Marra, Camillo, Di Tella, Sonia, Cotelli, Maria, Lodi, Raffaele, Tagliavini, Fabrizio, and Cappa, Stefano Francesco

Published
2024
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6. Validity, diagnostics and feasibility of the Italian version of the Montreal Cognitive Assessment (MoCA) in Huntington’s disease

Author

Aiello, Edoardo Nicolò, Solca, Federica, Torre, Silvia, Lafronza, Annalisa, Maranzano, Alessio, Bonetti, Ruggero, Scheveger, Francesco, Maffi, Sabrina, Ceccarelli, Consuelo, Scocchia, Marta, Casella, Melissa, Verde, Federico, Migliore, Simone, Silani, Vincenzo, Ticozzi, Nicola, Squitieri, Ferdinando, Ciammola, Andrea, and Poletti, Barbara

Published
2024
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10. Equating norms between the ALS Cognitive Behavioral Screen (ALS-CBS™) and the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) in non-demented ALS patients

Author

Aiello, Edoardo Nicolò, Solca, Federica, Greco, Lucia Catherine, Torre, Silvia, Carelli, Laura, Morelli, Claudia, Doretti, Alberto, Colombo, Eleonora, Messina, Stefano, Pain, Debora, Radici, Alice, Lizio, Andrea, Casiraghi, Jacopo, Cerri, Federica, Woolley, Susan, Murphy, Jennifer, Tremolizzo, Lucio, Appollonio, Ildebrando, Verde, Federico, Sansone, Valeria Ada, Lunetta, Christian, Silani, Vincenzo, Ticozzi, Nicola, and Poletti, Barbara

Published
2023
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12. Clinimetrics and feasibility of the Italian version of the Frontal Assessment Battery (FAB) in non-demented Parkinson’s disease patients

Author

Aiello, Edoardo Nicolò, D’Iorio, Alfonsina, Solca, Federica, Torre, Silvia, Bonetti, Ruggero, Scheveger, Francesco, Colombo, Eleonora, Maranzano, Alessio, Maderna, Luca, Morelli, Claudia, Doretti, Alberto, Amboni, Marianna, Vitale, Carmine, Verde, Federico, Ferrucci, Roberta, Barbieri, Sergio, Zirone, Eleonora, Priori, Alberto, Pravettoni, Gabriella, Santangelo, Gabriella, Silani, Vincenzo, Ticozzi, Nicola, Ciammola, Andrea, and Poletti, Barbara

Published
2023
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13. Clinimetrics of the cognitive section of the Italian ALS Cognitive Behavioral Screen (ALS-CBS™)

Author

Aiello, Edoardo Nicolò, Greco, Lucia Catherine, La Tona, Antonino, Solca, Federica, Torre, Silvia, Carelli, Laura, Pain, Debora, Radici, Alice, Lizio, Andrea, Casiraghi, Jacopo, Cerri, Federica, Brugnera, Agostino, Compare, Angelo, Woolley, Susan, Murphy, Jennifer, Tremolizzo, Lucio, Appollonio, Ildebrando, Verde, Federico, Silani, Vincenzo, Ticozzi, Nicola, Lunetta, Christian, Sansone, Valeria Ada, and Poletti, Barbara

Published
2023
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20. QSM-detected iron accumulation in the cerebellar gray matter is selectively associated with executive dysfunction in non-demented ALS patients.

Author

Aiello, Edoardo Nicolò, Contarino, Valeria Elisa, Conte, Giorgio, Solca, Federica, Curti, Beatrice, Maranzano, Alessio, Torre, Silvia, Casale, Silvia, Doretti, Alberto, Colombo, Eleonora, Verde, Federico, Silani, Vincenzo, Chunlei Liu, Cinnante, Claudia, Triulzi, Fabio Maria, Morelli, Claudia, Poletti, Barbara, and Ticozzi, Nicola

Subjects
EXECUTIVE function, AMYOTROPHIC lateral sclerosis, GRAY matter (Nerve tissue), MEMORY span, CEREBELLAR cortex
Abstract

Background: This study aimed to assess whether quantitative susceptibility imaging (QSM)-based measures of iron accumulation in the cerebellum predict cognitive and behavioral features in non-demented amyotrophic lateral sclerosis (ALS) patients. Methods: A total of ALS patients underwent 3-T MRI and a clinical assessment using the ALS Functional Rating Scale-Revised (ALSFRS-R) and the Edinburgh Cognitive and Behavioural ALS Screen (ECAS). Regression models were applied to each subscale of the cognitive section of the ECAS and the ECASCarer Interview to examine the effect of QSM-based measures in white and gray matter (WM; GM) of the cerebellum, separately for right, left, and bilateral cerebellar regions of interest (ROIs). These effects were compared to those of cerebellar volumetrics in WM/GM, right and left hemispheres while controlling for demographics, disease status, and total intracranial volume. Results: Higher QSM measures of the cerebellar GM on the left, right, and bilateral sides significantly predicted (ps = 0.003) a greater number of errors on the executive functioning (EF) subscale of the ECAS (ECAS-EF). Moreover, higher GM-related, QSM measures of the cerebellum were associated with an increased probability of a below-cut-off performance on the ECAS-EF (ps = 0.024). No significant effects were observed for QSM measures of the cerebellar WM or for volumetric measures on the ECAS-EF. Other ECAS measures showed no significant effects. Bilateral QSM measures of the cerebellar GM also selectively predicted performance on backward digit span and social cognition tasks. Discussion: Iron accumulation within the cerebellar GM, particularly in the cerebellar cortices, may be associated with executive functioning deficits in nondemented ALS patients. Therefore, QSM-based measures could be useful for identifying the neural correlates of extra-motor cognitive deficits in ALS patients. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Compensating for verbal-motor deficits in neuropsychological assessment in movement disorders: sensitivity and specificity of the ECAS in Parkinson’s and Huntington’s diseases

Author

Carelli, Laura, Solca, Federica, Migliore, Simone, Torre, Silvia, Brugnera, Agostino, Mancini, Francesca, Tagini, Sofia, Ferrucci, Roberta, Maffi, Sabrina, Ceccarelli, Consuelo, Pasquini, Jacopo, Sassone, Jenny, Squitieri, Ferdinando, Ciammola, Andrea, Silani, Vincenzo, and Poletti, Barbara

Published
2021
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22. Longitudinal feasibility of the Montreal Cognitive Assessment (MoCA) in non-demented ALS patients

Author

Aiello, Edoardo Nicolò, primary, Solca, Federica, additional, Torre, Silvia, additional, Colombo, Eleonora, additional, Maranzano, Alessio, additional, De Lorenzo, Alberto, additional, Patisso, Valerio, additional, Treddenti, Mauro, additional, Curti, Beatrice, additional, Morelli, Claudia, additional, Doretti, Alberto, additional, Verde, Federico, additional, Ferrucci, Roberta, additional, Barbieri, Sergio, additional, Ruggiero, Fabiana, additional, Priori, Alberto, additional, Silani, Vincenzo, additional, Ticozzi, Nicola, additional, and Poletti, Barbara, additional

Published
2024
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23. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

Author

Gendron, Tania F, Chew, Jeannie, Stankowski, Jeannette N, Hayes, Lindsey R, Zhang, Yong-Jie, Prudencio, Mercedes, Carlomagno, Yari, Daughrity, Lillian M, Jansen-West, Karen, Perkerson, Emilie A, O'Raw, Aliesha, Cook, Casey, Pregent, Luc, Belzil, Veronique, van Blitterswijk, Marka, Tabassian, Lilia J, Lee, Chris W, Yue, Mei, Tong, Jimei, Song, Yuping, Castanedes-Casey, Monica, Rousseau, Linda, Phillips, Virginia, Dickson, Dennis W, Rademakers, Rosa, Fryer, John D, Rush, Beth K, Pedraza, Otto, Caputo, Ana M, Desaro, Pamela, Palmucci, Carla, Robertson, Amelia, Heckman, Michael G, Diehl, Nancy N, Wiggs, Edythe, Tierney, Michael, Braun, Laura, Farren, Jennifer, Lacomis, David, Ladha, Shafeeq, Fournier, Christina N, McCluskey, Leo F, Elman, Lauren B, Toledo, Jon B, McBride, Jennifer D, Tiloca, Cinzia, Morelli, Claudia, Poletti, Barbara, Solca, Federica, Prelle, Alessandro, Wuu, Joanne, Jockel-Balsarotti, Jennifer, Rigo, Frank, Ambrose, Christine, Datta, Abhishek, Yang, Weixing, Raitcheva, Denitza, Antognetti, Giovanna, McCampbell, Alexander, Van Swieten, John C, Miller, Bruce L, Boxer, Adam L, Brown, Robert H, Bowser, Robert, Miller, Timothy M, Trojanowski, John Q, Grossman, Murray, Berry, James D, Hu, William T, Ratti, Antonia, Traynor, Bryan J, Disney, Matthew D, Benatar, Michael, Silani, Vincenzo, Glass, Jonathan D, Floeter, Mary Kay, Rothstein, Jeffrey D, Boylan, Kevin B, and Petrucelli, Leonard

Subjects
Clinical Research, Neurodegenerative, Brain Disorders, Acquired Cognitive Impairment, Dementia, Neurosciences, ALS, Rare Diseases, Clinical Trials and Supportive Activities, Genetics, Neurological, Adult, Aged, Amyotrophic Lateral Sclerosis, Animals, Biomarkers, Brain, C9orf72 Protein, Cell Line, Dinucleotide Repeats, Humans, Induced Pluripotent Stem Cells, Leukocytes, Mononuclear, Longitudinal Studies, Mice, Middle Aged, Neurons, Oligonucleotides, Antisense, Prognosis, RNA, Biological Sciences, Medical and Health Sciences
Abstract

There is no effective treatment for amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease. However, discovery of a G4C2 repeat expansion in the C9ORF72 gene as the most common genetic cause of ALS has opened up new avenues for therapeutic intervention for this form of ALS. G4C2 repeat expansion RNAs and proteins of repeating dipeptides synthesized from these transcripts are believed to play a key role in C9ORF72-associated ALS (c9ALS). Therapeutics that target G4C2 RNA, such as antisense oligonucleotides (ASOs) and small molecules, are thus being actively investigated. A limitation in moving such treatments from bench to bedside is a lack of pharmacodynamic markers for use in clinical trials. We explored whether poly(GP) proteins translated from G4C2 RNA could serve such a purpose. Poly(GP) proteins were detected in cerebrospinal fluid (CSF) and in peripheral blood mononuclear cells from c9ALS patients and, notably, from asymptomatic C9ORF72 mutation carriers. Moreover, CSF poly(GP) proteins remained relatively constant over time, boding well for their use in gauging biochemical responses to potential treatments. Treating c9ALS patient cells or a mouse model of c9ALS with ASOs that target G4C2 RNA resulted in decreased intracellular and extracellular poly(GP) proteins. This decrease paralleled reductions in G4C2 RNA and downstream G4C2 RNA-mediated events. These findings indicate that tracking poly(GP) proteins in CSF could provide a means to assess target engagement of G4C2 RNA-based therapies in symptomatic C9ORF72 repeat expansion carriers and presymptomatic individuals who are expected to benefit from early therapeutic intervention.

Published
2017

24. Medical Information Extraction With NLP-Powered QABots: A Real-World Scenario

Author

Crema, Claudio, Verde, Federico, Tiraboschi, Pietro, Marra, Camillo, Arighi, Andrea, Fostinelli, Silvia, Giuffre, Guido Maria, Maschio, Vera Pacoova Dal, L'Abbate, Federica, Solca, Federica, Poletti, Barbara, Silani, Vincenzo, Rotondo, Emanuela, Borracci, Vittoria, Vimercati, Roberto, Crepaldi, Valeria, Inguscio, Emanuela, Filippi, Massimo, Caso, Francesca, Rosati, Alessandra Maria, Quaranta, Davide, Binetti, Giuliano, Pagnoni, Ilaria, Morreale, Manuela, Burgio, Francesca, Maserati, Michelangelo Stanzani, Capellari, Sabina, Pardini, Matteo, Girtler, Nicola, Piras, Federica, Piras, Fabrizio, Lalli, Stefania, Perdixi, Elena, Lombardi, Gemma, Tella, Sonia Di, Costa, Alfredo, Capelli, Marco, Fundaro, Cira, Manera, Marina, Muscio, Cristina, Pellencin, Elisa, Lodi, Raffaele, Tagliavini, Fabrizio, and Redolfi, Alberto

Abstract

The advent of computerized medical recording systems in healthcare facilities has made data retrieval tasks easier, compared to manual recording. Nevertheless, the potential of the information contained within medical records remains largely untapped, mostly due to the time and effort required to extract data from unstructured documents. Natural Language Processing (NLP) represents a promising solution to this challenge, as it enables the use of automated text-mining tools for clinical practitioners. In this work, we present the architecture of the Virtual Dementia Institute (IVD), a consortium of sixteen Italian hospitals, using the NLP Extraction and Management Tool (NEMT), a (semi-) automated end-to-end pipeline that extracts relevant information from clinical documents and stores it in a centralized REDCap database. After defining a common Case Report Form (CRF) across the IVD hospitals, we implemented NEMT, the core of which is a Question Answering Bot (QABot) based on a modern NLP model. This QABot is fine-tuned on thousands of examples from IVD centers. Detailed descriptions of the process to define a common minimum dataset, Inter-Annotator Agreement calculated on clinical documents, and NEMT results are provided. The best QABot performance show an Exact Match score (EM) of 78.1%, a F1-score of 84.7%, a Lenient Accuracy (LAcc) of 0.834, and a Mean Reciprocal Rank (MRR) of 0.810. EM and F1 scores outperform the same metrics obtained with ChatGPTv3.5 (68.9% and 52.5%, respectively). With NEMT the IVD has been able to populate a database that will contain data from thousands of Italian patients, all screened with the same procedure. NEMT represents an efficient tool that paves the way for medical information extraction and exploitation for new research studies.

Published
2024
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25. Medical Information Extraction with NLP-Powered QABots: a Real-World Scenario

Author

Crema, Claudio, primary, Verde, Federico, additional, Tiraboschi, Pietro, additional, Marra, Camillo, additional, Arighi, Andrea, additional, Fostinelli, Silvia, additional, Giuffré, Guido Maria, additional, Maschio, Vera Pacoova Dal, additional, L'abbate, Federica, additional, Solca, Federica, additional, Poletti, Barbara, additional, Silani, Vincenzo, additional, Rotondo, Emanuela, additional, Borracci, Vittoria, additional, Vimercati, Roberto, additional, Crepaldi, Valeria, additional, Inguscio, Emanuela, additional, Filippi, Massimo, additional, Caso, Francesca, additional, Rosati, Alessandra Maria, additional, Quaranta, Davide, additional, Binetti, Giuliano, additional, Pagnoni, Ilaria, additional, Morreale, Manuela, additional, Burgio, Francesca, additional, Maserati, Michelangelo Stanzani, additional, Capellari, Sabina, additional, Pardini, Matteo, additional, Girtler, Nicola, additional, Piras, Federica, additional, Piras, Fabrizio, additional, Lalli, Stefania, additional, Perdixi, Elena, additional, Lombardi, Gemma, additional, Tella, Sonia Di, additional, Costa, Alfredo, additional, Capelli, Marco, additional, Fundarò, Cira, additional, Manera, Marina, additional, Muscio, Cristina, additional, Pellencin, Elisa, additional, Lodi, Raffaele, additional, Tagliavini, Fabrizio, additional, and Redolfi, Alberto, additional

Published
2023
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26. An exploratory study on counterfactual thinking in amyotrophic lateral sclerosis

Author

Poletti, Barbara, primary, Aiello, Edoardo Nicolò, additional, Tagini, Sofia, additional, Solca, Federica, additional, Torre, Silvia, additional, Colombo, Eleonora, additional, Maranzano, Alessio, additional, Bonetti, Ruggero, additional, Schevegher, Francesco, additional, Morelli, Claudia, additional, Doretti, Alberto, additional, Verde, Federico, additional, Barbieri, Sergio, additional, Mameli, Francesca, additional, Priori, Alberto, additional, Ferrucci, Roberta, additional, Silani, Vincenzo, additional, Cherubini, Paolo, additional, Pravettoni, Gabriella, additional, and Ticozzi, Nicola, additional

Published
2023
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27. Frontotemporal-spectrum disorders and functional independence in non-demented ALS patients.

Author

Aiello, Edoardo Nicolò, Solca, Federica, Torre, Silvia, Gentile, Francesco, Scheveger, Francesco, Olivero, Marco, Colombo, Eleonora, Maranzano, Alessio, Manzoni, Martina, Morelli, Claudia, Doretti, Alberto, Verde, Federico, Silani, Vincenzo, Ticozzi, Nicola, and Poletti, Barbara

Subjects
*AMYOTROPHIC lateral sclerosis, *FRONTOTEMPORAL dementia, *ACTIVITIES of daily living, *LINGUISTIC change, *APATHY, *DISEASE duration
Abstract

Background: The present study aimed at determining whether, net of motor confounders, neuropsychological features affect functional independence (FI) in activities of daily living (ADLs) in non-demented amyotrophic lateral sclerosis (ALS) patients. Methods: N = 88 ALS patients without frontotemporal dementia were assessed for FI—Katz's Basic ADL Scale (BADL) and Lawton-Brody's Instrumental ADL Scale (IADL)—, cognition—Edinburgh Cognitive and Behavioural ALS Screen (ECAS)—and behaviour—Beaumont Behavioural Inventory and Dimensional Apathy Scale. The association between cognitive and behavioural measures and BADL/IADL scores was assessed by covarying for demographics, anxiety and depression levels, disease duration and motor confounders—i.e. ALS Functional Rating Scale-Revised (ALSFRS-R) scores, progression rate and both King's and Milano-Torino stages. Results: Higher scores on the ECAS-Language were associated with higher IADL scores (p = 0.005), whilst higher apathetic features—as measured by the Dimensional Apathy Scale (DAS)—were inversely related to the BADL (p = 0.003). Whilst IADL scores were related to all ECAS-Language tasks, the DAS-Initiation was the only subscale associated with BADL scores. Patients with abnormal ECAS-Language (p = 0.023) and DAS (p = 0.008) scores were more functionally dependent than those without. Discussion: Among non-motor features, language changes and apathetic features detrimentally affect FI in non-demented ALS patients. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Validity, diagnostics and feasibility of the Italian version of the Montreal Cognitive Assessment (MoCA) in Huntington’s disease

Author

Aiello, Edoardo Nicolò, primary, Solca, Federica, additional, Torre, Silvia, additional, Lafronza, Annalisa, additional, Maranzano, Alessio, additional, Bonetti, Ruggero, additional, Scheveger, Francesco, additional, Maffi, Sabrina, additional, Ceccarelli, Consuelo, additional, Scocchia, Marta, additional, Casella, Melissa, additional, Verde, Federico, additional, Migliore, Simone, additional, Silani, Vincenzo, additional, Ticozzi, Nicola, additional, Squitieri, Ferdinando, additional, Ciammola, Andrea, additional, and Poletti, Barbara, additional

Published
2023
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30. Correction: Clinimetrics and feasibility of the Italian version of the Frontal Assessment Battery (FAB) in non-demented Parkinson’s disease patients

Author

Aiello, Edoardo Nicolò, primary, D’Iorio, Alfonsina, additional, Solca, Federica, additional, Torre, Silvia, additional, Bonetti, Ruggero, additional, Scheveger, Francesco, additional, Colombo, Eleonora, additional, Maranzano, Alessio, additional, Maderna, Luca, additional, Morelli, Claudia, additional, Doretti, Alberto, additional, Amboni, Marianna, additional, Vitale, Carmine, additional, Verde, Federico, additional, Ferrucci, Roberta, additional, Barbieri, Sergio, additional, Zirone, Eleonora, additional, Priori, Alberto, additional, Pravettoni, Gabriella, additional, Santangelo, Gabriella, additional, Silani, Vincenzo, additional, Ticozzi, Nicola, additional, Ciammola, Andrea, additional, and Poletti, Barbara, additional

Published
2023
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31. Bulbar involvement and cognitive features in amyotrophic lateral sclerosis: a retrospective study on 347 patients

Author

Aiello, Edoardo Nicolò, primary, Solca, Federica, additional, Torre, Silvia, additional, Patisso, Valerio, additional, De Lorenzo, Alberto, additional, Treddenti, Mauro, additional, Colombo, Eleonora, additional, Maranzano, Alessio, additional, Morelli, Claudia, additional, Doretti, Alberto, additional, Verde, Federico, additional, Silani, Vincenzo, additional, Ticozzi, Nicola, additional, and Poletti, Barbara, additional

Published
2023
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32. Phenotypic correlates of serum neurofilament light chain levels in amyotrophic lateral sclerosis

Author

Verde, Federico, primary, Milone, Ilaria, additional, Colombo, Eleonora, additional, Maranzano, Alessio, additional, Solca, Federica, additional, Torre, Silvia, additional, Doretti, Alberto, additional, Gentile, Francesco, additional, Manini, Arianna, additional, Bonetti, Ruggero, additional, Peverelli, Silvia, additional, Messina, Stefano, additional, Maderna, Luca, additional, Morelli, Claudia, additional, Poletti, Barbara, additional, Ratti, Antonia, additional, Silani, Vincenzo, additional, and Ticozzi, Nicola, additional

Published
2023
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33. Single task-level, 2SD-based cutoffs for the Italian version of the Edinburgh Cognitive and Behavioral ALS screen (ECAS).

Author

Poletti, Barbara, Aiello, Edoardo Nicolò, La Tona, Antonino, Solca, Federica, Torre, Silvia, Colombo, Eleonora, Maranzano, Alessio, Morelli, Claudia, Doretti, Alberto, Verde, Federico, Monti, Alessia, Brugnera, Agostino, Compare, Angelo, Ferrucci, Roberta, Barbieri, Sergio, Mameli, Francesca, Priori, Alberto, Pravettoni, Gabriella, Silani, Vincenzo, and Ticozzi, Nicola

Subjects
AMYOTROPHIC lateral sclerosis
Abstract

The present study aimed at deriving, by means of a traditional "2 standard deviation-based" (2SD) approach, single task-level cutoffs for the Italian version of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS). Cutoffs were derived – as M-2*SD – from the sample of healthy participants (HPs) included within 2016 Poletti et al.'s normative study – N = 248; 104 males; age: 57.8 ± 10.6; education: 14.1 ± 4.6 – separately for the four, original demographic classes: 1) education <14 years and age ≤60 years; 2) education <14 years and age >60 years; 3) education ≥14 years and age ≤60 years; 4) education ≥14 years and age >60 years. The prevalence of deficits on each task was then estimated within a cohort of N = 377 amyotrophic lateral sclerosis (ALS) patients without dementia. The distribution of abnormal performance prevalences was overall consistent with the cognitive phenotype of ALS. In conclusion, the single task-level cutoffs herewith provided for the Italian version of the ECAS, which complement those already available within Poletti et al.'s normative framework, will help better profile Italian ALS patients' cognitive phenotype within both clinical and research settings. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Coexistence of Amyotrophic Lateral Sclerosis and Alzheimer's Disease: Case Report and Review of the Literature.

Author

Verde, Federico, Aiello, Edoardo Nicolò, Adobbati, Laura, Poletti, Barbara, Solca, Federica, Tiloca, Cinzia, Sangalli, Davide, Maranzano, Alessio, Muscio, Cristina, Ratti, Antonia, Zago, Stefano, Ticozzi, Nicola, Frisoni, Giovanni Battista, and Silani, Vincenzo

Subjects
AMYOTROPHIC lateral sclerosis, ALZHEIMER'S disease, LITERATURE reviews, REPORTING of diseases, DISEASE duration, APOLIPOPROTEIN E4, CEREBRAL amyloid angiopathy
Abstract

We describe a case of amyotrophic lateral sclerosis (ALS) associated with Alzheimer's disease (AD) and review the literature about the coexistence of the two entities, highlighting the following: mean age at onset is 63.8 years, with slight female predominance; ALS tends to manifest after cognitive impairment and often begins in the bulbar region; average disease duration is 3 years; cognitive phenotype is mostly amnestic; the pattern of brain involvement is, in most cases, consistent with AD. Our case and the reviewed ones suggest that patients with ALS and dementia lacking unequivocal features of FTD should undergo additional examinations in order to recognize AD. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Standardization of the Italian ALS-CBS™ Caregiver Behavioral Questionnaire

Author

Aiello, Edoardo Nicolò, primary, Solca, Federica, additional, Greco, Lucia Catherine, additional, La Tona, Antonino, additional, Torre, Silvia, additional, Carelli, Laura, additional, Morelli, Claudia, additional, Doretti, Alberto, additional, Colombo, Eleonora, additional, Messina, Stefano, additional, Pain, Debora, additional, Radici, Alice, additional, Lizio, Andrea, additional, Casiraghi, Jacopo, additional, Cerri, Federica, additional, Brugnera, Agostino, additional, Compare, Angelo, additional, Woolley, Susan, additional, Murphy, Jennifer, additional, Tremolizzo, Lucio, additional, Appollonio, Ildebrando, additional, Verde, Federico, additional, Sansone, Valeria Ada, additional, Lunetta, Christian, additional, Silani, Vincenzo, additional, Ticozzi, Nicola, additional, and Poletti, Barbara, additional

Published
2023
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36. Italian reference values and brain correlates of verbal fluency index – vs standard verbal fluency test – to assess executive dysfunction in ALS

Author

Canu, Elisa, primary, Castelnovo, Veronica, additional, Rancoita, Paola MV, additional, Leocadi, Michela, additional, Lamanuzzi, Alessandra, additional, Spinelli, Edoardo Gioele, additional, Basaia, Silvia, additional, Riva, Nilo, additional, Poletti, Barbara, additional, Solca, Federica, additional, Verde, Federico, additional, Ticozzi, Nicola, additional, Silani, Vincenzo, additional, Abrahams, Sharon, additional, Filippi, Massimo, additional, and Agosta, Federica, additional

Published
2023
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37. Clinimetrics of the cognitive section of the Italian ALS Cognitive Behavioral Screen (ALS-CBS™)

Author

Aiello, Edoardo Nicolò, primary, Greco, Lucia Catherine, additional, La Tona, Antonino, additional, Solca, Federica, additional, Torre, Silvia, additional, Carelli, Laura, additional, Pain, Debora, additional, Radici, Alice, additional, Lizio, Andrea, additional, Casiraghi, Jacopo, additional, Cerri, Federica, additional, Brugnera, Agostino, additional, Compare, Angelo, additional, Woolley, Susan, additional, Murphy, Jennifer, additional, Tremolizzo, Lucio, additional, Appollonio, Ildebrando, additional, Verde, Federico, additional, Silani, Vincenzo, additional, Ticozzi, Nicola, additional, Lunetta, Christian, additional, Sansone, Valeria Ada, additional, and Poletti, Barbara, additional

Published
2022
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38. Serum levels of glial fibrillary acidic protein in patients with amyotrophic lateral sclerosis

Author

Verde, Federico, primary, Milone, Ilaria, additional, Maranzano, Alessio, additional, Colombo, Eleonora, additional, Torre, Silvia, additional, Solca, Federica, additional, Doretti, Alberto, additional, Gentile, Francesco, additional, Manini, Arianna, additional, Bonetti, Ruggero, additional, Peverelli, Silvia, additional, Messina, Stefano, additional, Maderna, Luca, additional, Morelli, Claudia, additional, Poletti, Barbara, additional, Ratti, Antonia, additional, Silani, Vincenzo, additional, and Ticozzi, Nicola, additional

Published
2022
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42. Diagnostic properties of the Frontal Assessment Battery (FAB) in Huntington’s disease

Author

Solca, Federica, primary, Aiello, Edoardo Nicolò, additional, Migliore, Simone, additional, Torre, Silvia, additional, Carelli, Laura, additional, Ferrucci, Roberta, additional, Priori, Alberto, additional, Verde, Federico, additional, Ticozzi, Nicola, additional, Maffi, Sabrina, additional, Ceccarelli, Consuelo, additional, Squitieri, Ferdinando, additional, Silani, Vincenzo, additional, Ciammola, Andrea, additional, and Poletti, Barbara, additional

Published
2022
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43. Cerebrospinal fluid/serum albumin quotient (Q-Alb) is not increased in Alzheimer’s disease compared to neurological disease controls: a retrospective study on 276 patients

Author

Giacopuzzi Grigoli, Eleonora, primary, Solca, Federica, additional, Milone, Ilaria, additional, Aiello, Edoardo Nicolò, additional, Dubini, Antonella, additional, Ratti, Antonia, additional, Torresani, Erminio, additional, Poletti, Barbara, additional, Ticozzi, Nicola, additional, Ciusani, Emilio, additional, Silani, Vincenzo, additional, and Verde, Federico, additional

Published
2022
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45. Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease

Author

Poletti, Barbara, primary, Solca, Federica, additional, Maffi, Sabrina, additional, Torre, Silvia, additional, Carelli, Laura, additional, Aiello, Edoardo Nicolò, additional, Ferrucci, Roberta, additional, Priori, Alberto, additional, Monti, Alessia, additional, Verde, Federico, additional, Ticozzi, Nicola, additional, Migliore, Simone, additional, Scaricamazza, Eugenia, additional, Casella, Melissa, additional, Squitieri, Ferdinando, additional, Ciammola, Andrea, additional, and Silani, Vincenzo, additional

Published
2022
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47. Motor, cognitive and behavioural profiles of C9orf72 expansion-related amyotrophic lateral sclerosis

Author

Colombo, Eleonora, primary, Poletti, Barbara, additional, Maranzano, Alessio, additional, Peverelli, Silvia, additional, Solca, Federica, additional, Colombrita, Claudia, additional, Torre, Silvia, additional, Tiloca, Cinzia, additional, Verde, Federico, additional, Bonetti, Ruggero, additional, Carelli, Laura, additional, Morelli, Claudia, additional, Ratti, Antonia, additional, Silani, Vincenzo, additional, and Ticozzi, Nicola, additional

Published
2022
Full Text
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