1. Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells
- Author
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Solange L. de Castro, Maria Nazaré C. Soeiro, and Maria de Nazareth Leal de Meirelles
- Subjects
Trypanosoma cruzi ,phenothiazines ,calcium antagonists ,parasite-host cell interactions ,Microbiology ,QR1-502 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Phenothiazines were observed to have a direct effect on Trypanosoma cruzi and on its in vitro interaction with host cells. They caused lysis of trypomastigotes (50 uM/24 h) and,to a lesser extent, epimastigote proliferation. Treatment of infected peritoneal macrophages with 12.5 uM chlorpromazine or triflupromazine inhibited the infection; this effect was found to be partially reversible if the drugs were removed after 24 h of treatment. At 60 uM, the drugs caused damage to amastigotes interiorized in heart muscle cells. However, the narrow margin of toxity between anti-trypanossomal activity and damage to host cells mitigates against in vivo investigation at the present time. Possible hypothesis for the mechanism of action of phenothiazines are discussed.
- Published
- 1992
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