286 results on '"Solé-Violán J"'
Search Results
2. Prior influenza vaccine is not a risk factor for bacterial coinfection in patients admitted to the ICU due to severe influenza
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Proaños, N.J., Reyes, L.F., Bastidas, A., Martín-Loeches, I., Díaz, E., Suberviola, B., Moreno, G., Bodí, M., Nieto, M., Estella, A., Sole-Violán, J., Curcio, D., Papiol, E., Guardiola, J., and Rodríguez, A.
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- 2022
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3. Impact of Aspergillus spp. isolation in the first 24 hours of admission in critically ill patients with severe influenza virus pneumonia
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Claverias, L., Daniel, X., Martín-Loeches, I., Vidal-Cortez, P., Gómez-Bertomeu, F., Trefler, S., Zaragoza, R., Borges-Sa, M., Reyes, L.F., Quindós, G., Peman, J., Bodí, M., Díaz, E., Sarvisé, C., Pico, E., Papiol, E., Solé-Violan, J., Marín-Corral, J., Guardiola, J.J., and Rodríguez, A.
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- 2022
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4. Association between blood caspase-8 levels and mortality of patients with malignant middle cerebral artery infarction
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Lorente, L., Martín, M.M., Pérez-Cejas, A., González-Rivero, A.F., Ramos-Gómez, L., Solé-Violán, J., Cáceres, J.J., Villacampa-Jiménez, J.J., and Jiménez, A.
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- 2022
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5. High serum nitrates levels in non-survivor COVID-19 patients
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Lorente, L., Gómez-Bernal, F., Martín, M.M., Navarro-Gonzálvez, J.A., Argueso, M., Perez, A., Ramos-Gómez, L., Solé-Violán, J., Marcos y Ramos, J.A., Ojeda, N., and Jiménez, A.
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- 2022
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6. Serum caspase-3 levels during the first week of traumatic brain injury
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Lorente, L., Martín, M.M., Pérez-Cejas, A., González-Rivero, A.F., Argueso, M., Ramos, L., Solé-Violán, J., Cáceres, J.J., Jiménez, A., and García-Marín, V.
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- 2021
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7. HLA genetic polymorphisms and prognosis of patients with COVID-19
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Lorente, Leonardo, Franco, Andrés, Barrios, Yvelise, Perez, Alina, Jiménez, Alejandro, Pérez-Cejas, Antonia, Pérez-Llombet, Alejandra, Uribe, Luis, González, Lourdes, Alvarez, Rocío, Martín, María M., Alcoba-Flórez, Julia, Estupiñan, Albano, Cáceres, Juan J., Vega, Paula, Gonzalez, Lucía, Solé-Violán, Jordi, Ojeda, Nazario, López, Sergio, Rodríguez-Pérez, Aurelio, Domínguez, Casimira, Marcos y Ramos, José Alberto, Zapata, María F., Ramos-Gómez, Luis, Ortiz-López, Raquel, Lorente, L., Martín, M.M., Franco, A., Barrios, Y., Cáceres, J.J., Solé-Violán, J., Perez, A., Marcos y Ramos, J.A., Ramos-Gómez, L., Ojeda, N., and Jiménez, A.
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- 2021
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8. DNA and RNA oxidative damage are associated to mortality in patients with cerebral infarction
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Lorente, L., Martín, M.M., González-Rivero, A.F., Pérez-Cejas, A., Abreu-González, P., Ramos, L., Argueso, M., Cáceres, J.J., Solé-Violán, J., Alvarez-Castillo, A., Jiménez, A., and García-Marín, V.
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- 2021
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9. Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine
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Author et al, Bateman, RM, Sharpe, MD, Jagger, JE, Ellis, CG, Solé-Violán, J, López-Rodríguez, M, Herrera-Ramos, E, Ruíz-Hernández, J, Borderías, L, Horcajada, J, González-Quevedo, N, Rajas, O, Briones, M, Rodríguez de Castro, F, Rodríguez Gallego, C, Esen, F, Orhun, G, Ergin Ozcan, P, Senturk, E, Ugur Yilmaz, C, Orhan, N, Arican, N, Kaya, M, Kucukerden, M, Giris, M, Akcan, U, Bilgic Gazioglu, S, Tuzun, E, Riff, R, Naamani, O, Douvdevani, A, Takegawa, R, Yoshida, H, Hirose, T, Yamamoto, N, Hagiya, H, Ojima, M, Akeda, Y, Tasaki, O, Tomono, K, Shimazu, T, Ono, S, Kubo, T, Suda, S, Ueno, T, Ikeda, T, Ogura, H, Takahashi, H, Kang, J, Nakamura, Y, Kojima, T, Izutani, Y, Taniguchi, T, O, M, Dinter, C, Lotz, J, Eilers, B, Wissmann, C, Lott, R, Meili, MM, Schuetz, PS, Hawa, H, Sharshir, M, Aburageila, M, Salahuddin, N, Chantziara, V, Georgiou, S, Tsimogianni, A, Alexandropoulos, P, Vassi, A, Lagiou, F, Valta, M, Micha, G, Chinou, E, Michaloudis, G, Kodaira, A, Imaizumi, H, De la Torre-Prados, MV, Garcia-De la Torre, A, Enguix-Armada, A, Puerto-Morlan, A, Perez-Valero, V, Garcia-Alcantara, A, Bolton, N, Dudziak, J, Bonney, S, and Tridente, A
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Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Good Health and Well Being ,Medical and Health Sciences ,Emergency & Critical Care Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
[This corrects the article DOI: 10.1186/s13054-016-1208-6.].
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- 2016
10. 36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.
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Bateman, RM, Sharpe, MD, Jagger, JE, Ellis, CG, Solé-Violán, J, López-Rodríguez, M, Herrera-Ramos, E, Ruíz-Hernández, J, Borderías, L, Horcajada, J, González-Quevedo, N, Rajas, O, Briones, M, Rodríguez de Castro, F, Rodríguez Gallego, C, Esen, F, Orhun, G, Ergin Ozcan, P, Senturk, E, Ugur Yilmaz, C, Orhan, N, Arican, N, Kaya, M, Kucukerden, M, Giris, M, Akcan, U, Bilgic Gazioglu, S, Tuzun, E, Riff, R, Naamani, O, Douvdevani, A, Takegawa, R, Yoshida, H, Hirose, T, Yamamoto, N, Hagiya, H, Ojima, M, Akeda, Y, Tasaki, O, Tomono, K, Shimazu, T, Ono, S, Kubo, T, Suda, S, Ueno, T, Ikeda, T, Ogura, H, Takahashi, H, Kang, J, Nakamura, Y, Kojima, T, Izutani, Y, Taniguchi, T, O, M, Dinter, C, Lotz, J, Eilers, B, Wissmann, C, Lott, R, Meili, MM, Schuetz, PS, Hawa, H, Sharshir, M, Aburageila, M, Salahuddin, N, Chantziara, V, Georgiou, S, Tsimogianni, A, Alexandropoulos, P, Vassi, A, Lagiou, F, Valta, M, Micha, G, Chinou, E, Michaloudis, G, Kodaira, A, Imaizumi, H, De la Torre-Prados, MV, Garcia-De la Torre, A, Enguix-Armada, A, Puerto-Morlan, A, Perez-Valero, V, Garcia-Alcantara, A, Bolton, N, Dudziak, J, Bonney, S, Tridente, A, and Nee, P
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Emergency & Critical Care Medicine ,Medical and Health Sciences - Published
- 2016
11. Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection
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Rodríguez, A., Reyes, L.F., Monclou, J., Suberviola, B., Bodí, M., Sirgo, G., Solé-Violán, J., Guardiola, J., Barahona, D., Díaz, E., Martín-Loeches, I., and Restrepo, M.I.
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- 2018
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12. Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and Thromboinflammation
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Alfaro, E., primary, Díaz-García, E., additional, García-Tovar, S., additional, Zamarrón, E., additional, Mangas, A., additional, Galera, R., additional, Ruiz-Hernández, J.J., additional, Solé-Violán, J., additional, Rodríguez-Gallego, C., additional, Van-Den-Rym, A., additional, Pérez-de-Diego, R., additional, Nanwani-Nanwani, K., additional, López-Collazo, E., additional, García-Río, F., additional, and Cubillos, C., additional
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- 2023
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13. Nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus treated with linezolid or vancomycin: A secondary economic analysis of resource use from a Spanish perspective
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Rello, J., Nieto, M., Solé-Violán, J., Wan, Y., Gao, X., Solem, C.T., De Salas-Cansado, M., Mesa, F., Charbonneau, C., and Chastre, J.
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- 2016
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14. Sustained high serum caspase-3 concentrations and mortality in septic patients
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Lorente, L., Martín, M. M., Pérez-Cejas, A., González-Rivero, A. F., López, R. O., Ferreres, J., Solé-Violán, J., Labarta, L., Díaz, C., Palmero, S., and Jiménez, A.
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- 2017
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15. IFITM3 and severe influenza virus infection. No evidence of genetic association
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López-Rodríguez, M., Herrera-Ramos, E., Solé-Violán, J., Ruíz-Hernández, J. J., Borderías, L., Horcajada, J. P., Lerma-Chippirraz, E., Rajas, O., Briones, M., Pérez-González, M. C., García-Bello, M. A., López-Granados, E., Rodriguez de Castro, F., and Rodríguez-Gallego, C.
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- 2016
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16. ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016
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Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., Shekerdemian, L. S., Coss-Bu, J. A., Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, J. C., Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, A. M. F., van Ieperen, S. N. M., Der Kinderen, E. P. H. M., Van Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Kyle, U. G., Akcan-Arikan, A., Silva, J. C., Mackey, G., Lusk, J., Goldsworthy, M., Shekerdemian, L. S., Coss-Bu, J. A., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano’, S. M., De Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, I. R., El Adawy, A. S., Mohammed, H. M. E. H., Mohamed, A. N., Parry, S. M., Knight, L. D., Denehy, L., De Morton, N., Baldwin, C. E., Sani, D., Kayambu, G., da Silva, V. Z. M., Phongpagdi, P., Puthucheary, Z. A., Granger, C. L., Rydingsward, J. E., Horkan, C. M., Christopher, K. B., McWilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, L. M., Rattray, J., Kenardy, J., Hull, A. M., Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, J. C., Rocha, L. L., De Freitas, F. F. M., Cavalheiro, A. M., Lucinio, N. M., Lobato, M. S., Ebeling, G., Kraegpoeth, A., Laerkner, E., De Brito-Ashurst, I., White, C., Gregory, S., Forni, L. G., Flowers, E., Curtis, A., Wood, C. A., Siu, K., Venkatesan, K., Muhammad, J. B. H., Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., de Molina, F. J. González, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, R. M., Palencia, E., Jareño, A., Granada, R. M., Ignacio, M. L., Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Riera, J., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Atchade, E., Mignot, T., Houzé, S., Jean-Baptiste, S., Thabut, G., Lortat-Jacob, B., Tanaka, S., Augustin, P., Desmard, M., Montravers, P., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, M. A., Patel, C., Mohankumar, L., Akhtar, N., Noriega, S. K. Pacheco, Aldana, N. Navarrete, León, J. L. Ávila, Baquero, J. Durand, Bernal, F. Fernández, Ahmadnia, E., Hadley, J. S., Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Gimillo, M. Rodriguez, Barinas, O. Diaz, Cortes, M. L. Blasco, Franco, J. Ferreres, Roca, J. M. Segura, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, P. J., Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Romero, J. C. García, Herrera, A. N. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Hualde, J. Barado, Hernández, A. Ansotegui, Irazabal, J. M. Guergué, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, E. Heusch, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, J. M., Arias-Verdu, M. D., Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., De La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Pertuz, E. D. Díaz, Hernández, A. Ansotegui, Romero, J. C. García, Sánchez, M. J. Gómez, Herrera, A. N. García, Ramírez, J. Roldán, Sanz, E. Regidor, Hualde, J. Barado, León, J. P. Tirapu, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, J. L., Pérez, H., Calpe, P., Alcala, M. A., Robaglia, D., Perez, C., Lan, S. K., Cunha, M. M., Moreira, T., Santos, F., Lafuente, E., Fernandes, M. J., Silva, J. G., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Herrera, A. N. García, Romero, J. C. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Echeverría, J. G. Armando, Hernández, A. Ansotegui, Hualde, J. Barado, Podlepich, V., Sokolova, E., Alexandrova, E., Lapteva, K., Kurtz, P., Shuinotsuka, C., Rabello, L., Vianna, G., Reis, A., Cairus, C., Salluh, J., Bozza, F., Torres, J. C. Barrios, Araujo, N. J. Fernández, García-Olivares, P., Keough, E., Dalorzo, M., Tang, L. K., De Sousa, I., Díaz, M., Marcos-Zambrano, L. J., Guerrero, J. E., Gomez, S. E. Zamora, Lopez, G. D. Hernandez, Cuellar, A. I. Vazquez, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Bhasin, D., Rai, S., Singh, H., Gupta, O., Bhattal, M. K., Sampley, S., Sekhri, K., Nandha, R., Aliaga, F. A., Olivares, F., Appiani, F., Farias, P., Alberto, F., Hernández, A., Pons, S., Sonneville, R., Bouadma, L., Neuville, M., Mariotte, E., Radjou, A., Lebut, J., Chemam, S., Voiriot, G., Dilly, M. P., Mourvillier, B., Dorent, R., Nataf, P., Wolff, M., Timsit, J. F., Ediboglu, O., Ataman, S., Ozkarakas, H., Kirakli, C., Vakalos, A., Avramidis, V., Obukhova, O., Kurmukov, I. A., Kashiya, S., Golovnya, E., Baikova, V. N., Ageeva, T., Haritydi, T., Kulaga, E. V., Rios-Toro, J. J., Perez-Borrero, L., Aguilar-Alonso, E., Arias-Verdu, M. D., Garcia-Alvarez, J. M., Lopez-Caler, C., De La Fuente-Martos, C., Rodriguez-Fernandez, S., Sanchez-Orézzoli, M. Gomez, Martin-Gallardo, F., Nikhilesh, J., Joshi, V., Villarreal, E., Ruiz, J., Gordon, M., Quinza, A., Gimenez, J., Piñol, M., Castellanos, A., Ramirez, P., Jeon, Y. D., Jeong, W. Y., Kim, M. H., Jeong, I. Y., Ahn, M. Y., Ahn, J. Y., Han, S. H., Choi, J. Y., Song, Y. G., Kim, J. M., Ku, N. S., Shah, H., Kellner, F., Rezai, F., Mistry, N., Yodice, P., Ovnanian, V., Fless, K., Handler, E., Alejos, R. Martínez, Romeu, J. D. Martí, Antón, D. González, Quinart, A., Martí, A. Torres, Llaurado-Serra, M., Lobo-Civico, A., Ventura-Rosado, A., Piñol-Tena, A., Pi-Guerrero, M., Paños-Espinosa, C., Peralvo-Bernat, M., Marine-Vidal, J., Gonzalez-Engroba, R., Montesinos-Cerro, N., Treso-Geira, M., Valeiras-Valero, A., Martinez-Reyes, L., Sandiumenge, A., Jimenez-Herrera, M. F., Helyar, S., Riozzi, P., Noon, A., Hallows, G., Cotton, H., Keep, J., Hopkins, P. A., Taggu, A., Renuka, S., Sampath, S., Rood, P. J. T., Frenzel, T., Verhage, R., Bonn, M., Pickkers, P., van der Hoeven, J. G., van den Boogaard, M., Corradi, F., Melnyk, L., Moggia, F., Pienovi, R., Adriano, G., Brusasco, C., Mariotti, L., Lattuada, M., Bloomer, M. J., Coombs, M., Ranse, K., Endacott, R., Maertens, B., Blot, K., Blot, S., Amerongen, M. P. van Nieuw, van der Heiden, E. S., Twisk, J. W. R., Girbes, A. R. J., Spijkstra, J. J., Riozzi, P., Helyar, S., Cotton, H., Hallows, G., Noon, A., Bell, C., Peters, K., Feehan, A., Keep, J., Hopkins, P. A., Churchill, K., Hawkins, K., Brook, R., Paver, N., Endacott, R., Maistry, N., van Wijk, A., Rouw, N., van Galen, T., Evelein-Brugman, S., Taggu, A., Krishna, B., Sampath, S., Putzu, A., Fang, M., Berto, M. Boscolo, Belletti, A., Cassina, T., Cabrini, L., Mistry, M., Alhamdi, Y., Welters, I., Abrams, S. T., Toh, C. H., Han, H. S., Gil, E. M., Lee, D. S., Park, C. M., Winder-Rhodes, S., Lotay, R., Doyle, J., Ke, M. W., Huang, W. C., Chiang, C. H., Hung, W. T., Cheng, C. C., Lin, K. C., Lin, S. C., Chiou, K. R., Wann, S. R., Shu, C. W., Kang, P. L., Mar, G. Y., Liu, C. P., Dubó, S., Aquevedo, A., Jibaja, M., Berrutti, D., Labra, C., Lagos, R., García, M. F., Ramirez, V., Tobar, M., Picoita, F., Peláez, C., Carpio, D., Alegría, L., Hidalgo, C., Godoy, K., Bakker, J., Hernández, G., Sadamoto, Y., Katabami, K., Wada, T., Ono, Y., Maekawa, K., Hayakawa, M., Sawamura, A., Gando, S., Marin-Mateos, H., Perez-Vela, J. L., Garcia-Gigorro, R., Peiretti, M. A. Corres, Lopez-Gude, M. 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J., Gonzalez, C. A., Pinto, J. L., Orozco, V., Patiño, J. A., Garcia, P. K., Contreras, K. M., Rodriguez, P., Echeverri, J. E., GETGAG Working Group, JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group, CAPCRI Study, for the ReVA Research Network and the PROVE Network Investigators, from the FROG ICU Investigators, The WIND study group, Plug Working Group, GETGAG/SEMICYUC, AKI Research Group, St George’s University of London, IPREA Study Group, FINNRESUSCI Study Group, PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre, ENVIN-HELICS Study Group, ARIAM registry of adult cardiac surgery, The Rapid Diagnosis of Infections in the Critically Ill Team, Tokyo Womens Medical University, PLUG working group, PLUG Working Group, On behalf of Okayama Research Investigation Organizing Network (ORION)investigators, PS-ICU Group, Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group, Student Research Committee - Shiraz University of Medical Sciences, ARIAM-ANDALUCIA, The WIND study group, PLUG Working Group, The WIND study group, PLUG Working Group, and Plug working group
- Published
- 2016
- Full Text
- View/download PDF
17. Treatment of Ventilator-Associated Pneumonia
- Author
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Solé-Violán, J., Rodríguez de Castro, F., Rello, Jordi, editor, and Wunderink, Richard G., editor
- Published
- 2001
- Full Text
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18. Association between apoptosis and mortality in severe septic patients
- Author
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Lorente, L, Martín, M, González-Rivero, A, Ferreres, J, Solé-Violán, J, Labarta, L, Díaz, C, Jiménez, A, and Borreguero-León, J
- Published
- 2015
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19. Lower platelet mitochondrial function in severe septic patients than in controls
- Author
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Lorente, L, Martin, M, Blanquer, J, Solé-Violán, J, Labarta, L, Díaz, C, Jiménez, A, López-Gallardo, E, Montoya, J, and Ruiz-Pesini, E
- Published
- 2015
- Full Text
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20. A Differential Therapeutic consideration for use of Corticosteroids according to Established COVID-19 Clinical Phenotypes in Critically ill Patients
- Author
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Moreno G, Ruiz-Botella M, Martín-Loeches I, Alvarez JG, Herrera MJ, Bodí M, Armestar F, Parra AM, Estella Á, Trefler S, García RJ, Paya JM, Cortes PV, Díaz E, Ferrer R, Albaya-Moreno A, Socias-Crespi L, Goytisolo JMB, Chinesta SS, Loza A, Espina LF, Laderas JCP, deAlba-Aparicio M, Montori LS, Perapoch IV, Hidalgo V, Gutiérrez VF, Ortega AMC, Serrano FM, Nieto M, Cortes MB, Marín-Corral J, Solé-Violán J, Rodríguez A, and on behalf COVID-19 SEMICYUC working Group
- Subjects
COVID-19, Corticosteroids, ICU Mortality, Phenotypes, SARS-CoV2-pneumonia, unsupervised clustering - Abstract
To determine if the use of corticosteroids was associated with Intensive Care Unit (ICU) mortality among whole population and pre-specified clinical phenotypes.
- Published
- 2021
21. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
- Author
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Bastard, P. Gervais, A. Voyer, T.L. Rosain, J. Philippot, Q. Manry, J. Michailidis, E. Hoffmann, H.-H. Eto, S. Garcia-Prat, M. Bizien, L. Parra-Martínez, A. Yang, R. Haljasmägi, L. Migaud, M. Särekannu, K. Maslovskaja, J. De Prost, N. Tandjaoui-Lambiotte, Y. Luyt, C.-E. Amador-Borrero, B. Gaudet, A. Poissy, J. Morel, P. Richard, P. Cognasse, F. Troya, J. Trouillet-Assant, S. Belot, A. Saker, K. Garçon, P. Rivière, J.G. Lagier, J.-C. Gentile, S. Rosen, L.B. Shaw, E. Morio, T. Tanaka, J. Dalmau, D. Tharaux, P.-L. Sene, D. Stepanian, A. Megarbane, B. Triantafyllia, V. Fekkar, A. Heath, J.R. Franco, J.L. Anaya, J.-M. Solé-Violán, J. Imberti, L. Biondi, A. Bonfanti, P. Castagnoli, R. Delmonte, O.M. Zhang, Y. Snow, A.L. Holland, S.M. Biggs, C.M. Moncada-Vélez, M. Arias, A.A. Lorenzo, L. Boucherit, S. Coulibaly, B. Anglicheau, D. Planas, A.M. Haerynck, F. Duvlis, S. Nussbaum, R.L. Ozcelik, T. Keles, S. Bousfiha, A.A. El Bakkouri, J. Ramirez-Santana, C. Paul, S. Pan-Hammarström, Q. Hammarström, L. Dupont, A. Kurolap, A. Metz, C.N. Aiuti, A. Casari, G. Lampasona, V. Ciceri, F. Barreiros, L.A. Dominguez-Garrido, E. Vidigal, M. Zatz, M. Van De Beek, D. Sahanic, S. Tancevski, I. Stepanovskyy, Y. Boyarchuk, O. Nukui, Y. Tsumura, M. Vidaur, L. Tangye, S.G. Burrel, S. Duffy, D. Quintana-Murci, L. Klocperk, A. Kann, N.Y. Shcherbina, A. Lau, Y.-L. Leung, D. Coulongeat, M. Marlet, J. Koning, R. Reyes, L.F. Chauvineau-Grenier, A. Venet, F. Monneret, G. Nussenzweig, M.C. Arrestier, R. Boudhabhay, I. Baris-Feldman, H. Hagin, D. Wauters, J. Meyts, I. Dyer, A.H. Kennelly, S.P. Bourke, N.M. Halwani, R. Sharif-Askari, N.S. Dorgham, K. Sallette, J. Sedkaoui, S.M. AlKhater, S. Rigo-Bonnin, R. Morandeira, F. Roussel, L. Vinh, D.C. Ostrowski, S.R. Condino-Neto, A. Prando, C. Bondarenko, A. Spaan, A.N. Gilardin, L. Fellay, J. Lyonnet, S. Bilguvar, K. Lifton, R.P. Mane, S. Anderson, M.S. Boisson, B. Béziat, V. Zhang, S.-Y. Andreakos, E. Hermine, O. Pujol, A. Peterson, P. Mogensen, T.H. Rowen, L. Mond, J. Debette, S. De Lamballerie, X. Duval, X. Mentré, F. Zins, M. Soler-Palacin, P. Colobran, R. Gorochov, G. Solanich, X. Susen, S. Martinez-Picado, J. Raoult, D. Vasse, M. Gregersen, P.K. Piemonti, L. Rodríguez-Gallego, C. Notarangelo, L.D. Su, H.C. Kisand, K. Okada, S. Puel, A. Jouanguy, E. Rice, C.M. Tiberghien, P. Zhang, Q. Cobat, A. Abel, L. Casanova, J.-L. Alavoine, L. Behillil, S. Burdet, C. Charpentier, C. Dechanet, A. Descamps, D. Ecobichon, J.-L. Enouf, V. Frezouls, W. Houhou, N. Kafif, O. Lehacaut, J. Letrou, S. Lina, B. Lucet, J.-C. Manchon, P. Nouroudine, M. Piquard, V. Quintin, C. Thy, M. Tubiana, S. Van Der Werf, S. Vignali, V. Visseaux, B. Yazdanpanah, Y. Chahine, A. Waucquier, N. Migaud, M.-C. Deplanque, D. Djossou, F. Mergeay-Fabre, M. Lucarelli, A. Demar, M. Bruneau, L. Gerardin, P. Maillot, A. Payet, C. Laviolle, B. Laine, F. Paris, C. Desille-Dugast, M. Fouchard, J. Malvy, D. Nguyen, D. Pistone, T. Perreau, P. Gissot, V. Le Goas, C. Montagne, S. Richard, L. Chirouze, C. Bouiller, K. Desmarets, M. Meunier, A. Lefevre, B. Jeulin, H. Legrand, K. Lomazzi, S. Tardy, B. Gagneux-Brunon, A. Bertholon, F. Botelho-Nevers, E. Christelle, K. Nicolas, L. Roufai, L. Amat, K. Couffin-Cadiergues, S. Esperou, H. Hendou, S. Townsend, L. Cheallaigh, C.N. Bergin, C. Martin-Loeches, I. Dunne, J. Conlon, N. O'Farrelly, C. Abad, J. Accordino, G. Achille, C. Aguilera-Albesa, S. Aguilo-Cucurull, A. Ozkan, E.A. Darazam, I.A. Albisures, J.A.R. Aldave, J.C. Ramos, M.A. Khan, T.A. Aliberti, A. Nadji, S.A. Alkan, G. AlKhater, S.A. Allardet-Servent, J. Allende, L.M. Alonso-Arias, R. Alshahrani, M.S. Alsina, L. Alyanakian, M.-A. Borrero, B.A. Amoura, Z. Antoli, A. Aubart, M. Auguet, T. Avramenko, I. Aytekin, G. Azot, A. Bahram, S. Bajolle, F. Baldanti, F. Baldolli, A. Ballester, M. Feldman, H.B. Barrou, B. Barzaghi, F. Basso, S. Bayhan, G.I. Bezrodnik, L. Bilbao, A. Blanchard-Rohner, G. Blanco, I. Blandinieres, A. Blazquez-Gamero, D. Bleibtreu, A. Bloomfield, M. Bolivar-Prados, M. Borghesi, A. Borie, R. Botdhlo-Nevers, E. Bousquet, A. Boutolleau, D. Bouvattier, C. Bravais, J. Briones, M.L. Brunner, M.-E. Bruno, R. Bueno, M.R.P. Bukhari, H. Bustamante, J. Agra, J.J.C. Capra, R. Carapito, R. Carrabba, M. Casasnovas, C. Caseris, M. Cassaniti, I. Castelle, M. Castelli, F. De Vera, M.C. Castro, M.V. Catherinot, E. Celik, J.B. Ceschi, A. Chalumeau, M. Charbit, B. Cheng, M.P. Clave, P. Clotet, B. Codina, A. Cohen, Y. Comarmond, C. Combes, A. Comoli, P. Corsico, A.G. Coşkuner, T. Cvetkovski, A. Cyrus, C. Danion, F. Darley, D.R. Das, V. Dauby, N. Dauger, S. De Munter, P. De Pontual, L. Dehban, A. Delplancq, G. Demoule, A. Desguerre, I. Di Sabatino, A. Diehl, J.-L. Dobbelaere, S. Dubost, C. Ekwall, O. Bozdemir, Ş.E. Elnagdy, M.H. Emiroglu, M. Endo, A. Erdeniz, E.H. Aytekin, S.E. Lasa, M.P.E. Euvrard, R. Fabio, G. Faivre, L. Falck, A. Fartoukh, M. Faure, M. Arquero, M.F. Ferrer, R. Ferreres, J. Flores, C. Francois, B. Fumado, V. Fung, K.S.C. Fusco, F. Gagro, A. Solis, B.G. Gaussem, P. Gayretli, Z. Gil-Herrera, J. Gatineau, A.G. Girona-Alarcon, M. Godinez, K.A.C. Goffard, J.-C. Gonzales, N. Gonzalez-Granado, L.I. Gonzalez-Montelongo, R. Guerder, A. Gulhan, B. Gumucio, V.D. Hanitsch, L.G. Gunst, J. Gut, M. Hadjadj, J. Hancerli, S. Hariyan, T. Hatipoglu, N. Heppekcan, D. Hernandez-Brito, E. Ho, P.-K. Holanda-Pena, M.S. Horcajada, J.P. Hraiech, S. Humbert, L. Hung, I.F.N. Iglesias, A.D. Inigo-Campos, A. Jamme, M. Arranz, M.J. Jimeno, M.-T. Jordan, I. Kanik-Yuksek, S. Kara, Y.B. Karahan, A. Karbuz, A. Yasar, K.K. Kasapcopur, O. Kashimada, K. Demirkol, Y.K. Kido, Y. Kizil, C. Kilic, A.O. Koutsoukou, A. Krol, Z.J. Ksouri, H. Kuentz, P. Kwan, A.M.C. Kwan, Y.W.M. Kwok, J.S.Y. Lam, D.S.Y. Lampropoulou, V. Lanternier, F. Le Bourgeois, F. Leo, Y.-S. Lopez, R.L. Levin, M. Levy, M. Levy, R. Li, Z. Lilleri, D. Lima, E.J.A.B. Linglart, A. Lopez-Collazo, E. Lorenzo-Salazar, J.M. Louapre, C. Lubetzki, C. Lung, K.-C. Lye, D.C. Magnone, C. Mansouri, D. Marchioni, E. Marioli, C. Marjani, M. Marques, L. Pereira, J.M. Martin-Nalda, A. Pueyo, D.M. Marzana, I. Mata-Martinez, C. Mathian, A. Matos, L.R.B. Matthews, G.V. Mayaux, J. McLaughlin-Garcia, R. Meersseman, P. Mege, J.-L. Mekontso-Dessap, A. Melki, I. Meloni, F. Meritet, J.-F. Merlani, P. Akcan, O.M. Mezidi, M. Migeotte, I. Millereux, M. Million, M. Mirault, T. Mircher, C. Mirsaeidi, M. Mizoguchi, Y. Modi, B.P. Mojoli, F. Moncomble, E. Melian, A.M. Martinez, A.M. Morange, P.-E. Mordacq, C. Morelle, G. Mouly, S.J. Munoz-Barrera, A. Nafati, C. Nagashima, S. Nakagama, Y. Neven, B. Neves, J.F. Ng, L.F.P. Ng, Y.-Y. Nielly, H. Medina, Y.N. Cuadros, E.N. Ocejo-Vinyals, J.G. Okamoto, K. Oualha, M. Ouedrani, A. Ozkaya-Parlakay, A. Pagani, M. Papadaki, M. Parizot, C. Parola, P. Pascreau, T. Paz-Artal, E. Pedraza, S. Pellecer, N.C.G. Pellegrini, S. De Diego, R.P. Perez-Fernandez, X.L. Philippe, A. Picod, A. De Chambrun, M.P. Piralla, A. Planas-Serra, L. Ploin, D. Poncelet, G. Poulakou, G. Pouletty, M.S. Pourshahnazari, P. Qiu-Chen, J.L. Quentric, P. Rambaud, T. Raoult, V. Rebillat, A.-S. Redin, C. Resmini, L. Ricart, P. Richard, J.-C. Rivet, N. Rocamora-Blanch, G. Rodero, M.P. Rodrigo, C. Rodriguez, L.A. Rodriguez-Palmero, A. Romero, C.S. Rothenbuhler, A. Roux, D. Rovina, N. Rozenberg, F. Ruch, Y. Ruiz, M. Del Prado, M.Y.R. Ruiz-Rodriguez, J.C. Sabater-Riera, J. Saks, K. Salagianni, M. Sanchez, O. Sanchez-Montalva, A. Sanchez-Ramon, S. Schidlowski, L. Schluter, A. Schmidt, J. Schmidt, M. Schuetz, C. Schweitzer, C.E. Scolari, F. Sediva, A. Seijo, L. Seminario, A.G. Seng, P. Senoglu, S. Seppanen, M. Llovich, A.S. Shahrooei, M. Siguret, V. Siouti, E. Smadja, D.M. Smith, N. Sobh, A. Soler, C. Sozeri, B. Stella, G.M. Stepanovskiy, Y. Stoclin, A. Taccone, F. Taupin, J.-L. Tavernier, S.J. Terrier, B. Thiery, G. Thorball, C. Thorn, K. Thumerelle, C. Tipu, I. Tolstrup, M. Tomasoni, G. Toubiana, J. Alvarez, J.T. Tsang, O.T.Y. Tserel, L. Tso, E.Y.K. Tucci, A. Oz, Ş.K.T. Ursini, M.V. Utsumi, T. Uzunhan, Y. Vabres, P. Valencia-Ramos, J. Van Den Rym, A.M. Vandernoot, I. Velez-Santamaria, V. Veliz, S.P.Z. Vidigal, M.C. Viel, S. Vilain, C. Vilaire-Meunier, M.E. Villar-Garcia, J. Vincent, A. Vogt, G. Voiriot, G. Volokha, A. Vuotto, F. Wauters, E. Wu, A.K.L. Wu, T.-C. Yahşi, A. Yesilbas, O. Yildiz, M. Young, B.E. Yukselmiş, U. Zecca, M. Zuccaro, V. Van Praet, J. Lambrecht, B.N. Van Braeckel, E. Bosteels, C. Hoste, L. Hoste, E. Bauters, F. De Clercq, J. Heijmans, C. Slabbynck, H. Naesens, L. Florkin, B. Boulanger, C. Vanderlinden, D. Allavena, C. Andrejak, C. Angoulvant, F. Azoulay, C. Bachelet, D. Bartoli, M. Basmaci, R. Behillill, S. Beluze, M. Benech, N. Benkerrou, D. Bhavsar, K. Bitker, L. Bouadma, L. Bouscambert-Duchamp, M. Paz, P.C. Cervantes-Gonzalez, M. Chair, A. Coelho, A. Cordel, H. Couffignal, C. D'Ortenzio, E. De Montmollin, E. Debard, A. Debray, M.-P. Desvallee, M. Diallo, A. Diouf, A. Dorival, C. Dubos, F. Eloy, P. Epaulard, O. Esposito-Farase, M. Etienne, M. Garot, D. Gault, N. Gaymard, A. Ghosn, J. Gigante, T. Gilg, M. Goehringer, F. Guedj, J. Hoctin, A. Hoffmann, I. Houas, I. Hulot, J.-S. Jaafoura, S. Kaguelidou, F. Kali, S. Kerroumi, Y. Khalil, A. Khan, C. Kimmoun, A. Laouenan, C. Laribi, S. Le, M. Le Bris, C. Le Gac, S. Le Hingrat, Q. Le Mestre, S. Le Nagard, H. Lemaignen, A. Lemee, V. Lescure, F.-X. Levy, Y. Lingas, G. Lucet, J.C. MacHado, M. Mambert, M. Manuel, A. Meziane, A. Mouquet, H. Mullaert, J. Neant, N. Noret, M. Papadopoulos, A. Paul, C. Peiffer-Smadja, N. Peigne, V. Petrov-Sanchez, V. Peytavin, G. Pham, H. Picone, O. Puechal, O. Rosa-Calatrava, M. Rossignol, B. Rossignol, P. Roy, C. Schneider, M. Su, R. Tardivon, C. Tellier, M.-C. Teoule, F. Terrier, O. Timsit, J.F. Tual, C. Vanel, N. Veislinger, A. Wiedemann, A. Danielson, J.J. Dobbs, K. Kashyap, A. Ding, L. Dalgard, C.L. Sottini, A. Quaresima, V. Quiros-Roldan, E. Rossi, C. Bettini, L.R. D'Angio, M. Beretta, I. Montagna, D. Licari, A. Marseglia, G.L. Storgaard, M. Jorgensen, S. Al-Muhsen, S. Al-Mulla, F. Arias, A.A. Bogunovic, D. Bolze, A. Brodin, P. Bryceson, Y. Bustamante, C.D. Butte, M.J. Chakravorty, S. Christodoulou, J. Constantinescu, S.N. Cooper, M.A. Desai, M. Drolet, B.A. El Baghdadi, J. Espinosa-Padilla, S. Froidure, A. Henrickson, S.E. Hsieh, E.W.Y. Husebye, E.S. Imai, K. Itan, Y. Jarvis, E.D. Karamitros, T. Ku, C.-L. Ling, Y. Lucas, C.L. Maniatis, T. Marodi, L. Milner, J.D. Mironska, K. Novelli, A. Novelli, G. Renia, L. Resnick, I. Sancho-Shimizu, V. Seppanen, M.R.J. Shahrooei, M. Slaby, O. Tayoun, A.A. Ramaswamy, S. Turvey, S.E. Furkan Uddin, K.M. Uddin, M.J. Von Bernuth, H. Zawadzki, P. Bigio, B. De La Chapelle, A. Chen, J. Chrabieh, M. Liu, D. Nemirowskaya, Y. Cruz, I.M. Materna, M. Pelet, S. Seeleuthner, Y. Thibault, C. Liu, Z. Foti, G. Bellani, G. Citerio, G. Contro, E. Pesci, A. Valsecchi, M.G. Cazzaniga, M. Batten, I. Reddy, C. McElheron, M. Noonan, C. Connolly, E. Fallon, A. Erikstrup, C. Pedersen, O.B. Sorensen, E. Mikkelsen, S. Dinh, K.M. Larsen, M.A.H. Paulsen, I.W. Von Stemann, J.H. Hansen, M.B. Annereau, J.-P. Briseno-Roa, L. Gribouval, O. Pelet, A. Alcover, A. Aschard, H. Bousso, P. Bruhns, P. Cerf-Bensussan, N. Cumano, A. D'Enfert, C. Deriano, L. Dillies, M.-A. Di Santo, J. Dromer, F. Eberl, G. Enninga, J. Gomperts-Boneca, I. Hasan, M. Hedestam, G.K. Hercberg, S. Ingersoll, M.A. Lantz, O. Kenny, R.A. Menager, M. Michel, F. Patin, E. Pellegrini, S. Rausell, A. Rieux-Laucat, F. Rogge, L. Fontes, M. Sakuntabhai, A. Schwartz, O. Schwikowski, B. Shorte, S. Tangy, F. Toubert, A. Touvier, M. Ungeheuer, M.-N. Zimmer, C. Albert, M.L. Van Agtmael, M. Algera, A.G. Appelman, B. Van Baarle, F. Bax, D. Beudel, M. Bogaard, H.J. Bomers, M. Bonta, P. Bos, L. Botta, M. De Brabander, J. De Bree, G. De Bruin, S. Buis, D.T.P. Bugiani, M. Bulle, E. Chouchane, O. Cloherty, A. Dijkstra, M. Dongelmans, D.A. Dujardin, R.W.G. Elbers, P. Fleuren, L. Geerlings, S. Geijtenbeek, T. Girbes, A. Goorhuis, B. Grobusch, M.P. Hafkamp, F. Hagens, L. Hamann, J. Harris, V. Hemke, R. Hermans, S.M. Heunks, L. Hollmann, M. Horn, J. Hovius, J.W. De Jong, M.D. Lim, E.H.T. Van Mourik, N. Nellen, J. Nossent, E.J. Paulus, F. Peters, E. Pina-Fuentes, D.A.I. Van Der Poll, T. Preckel, B. Prins, J.M. Raasveld, J. Reijnders, T. De Rotte, M.C.F.J. Schinkel, M. Schultz, M.J. Schrauwen, F.A.P. Schuurman, A. Schuurmans, J. Sigaloff, K. Slim, M.A. Smeele, P. Smit, M. Stijnis, C.S. Stilma, W. Teunissen, C. Thoral, P. Tsonas, A.M. Tuinman, P.R. Van Der Valk, M. Veelo, D. Volleman, C. De Vries, H. Vught, L.A. Van Vugt, M. Wouters, D. Zwinderman, A.H. Brouwer, M.C. Joost Wiersinga, W. Vlaar, A.P.J. Nadif, R. Goldberg, M. Ozguler, A. Henny, J. Lemonnier, S. Coeuret-Pellicer, M. Le Got, S. Tzourio, C. Dufouil, C. Soumare, A. Lachaize, M. Fievet, N. Flaig, A. Martin, F. Bonneaudeau, B. Cannet, D. Gallian, P. Jeanne, M. Perroquin, M. Hamzeh-Cognasse, H. CoV-Contact Cohort St James's Hospital, SARS CoV2 Interest group COVID Clinicians French COVID Cohort Study Group NIAID Immune Response to COVID Group Danish CHGE COVID Human Genetic Effort HGID Lab COVID-STORM Clinicians NH-COVAIR Study Group The Danish Blood Donor Study (DBDS) Imagine COVID-Group The Milieu Interieur Consortium Amsterdam UMC Covid-19 Biobank CONSTANCES cohort 3C-Dijon Study Cerba HealthCare Etablissement du Sang study group
- Abstract
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals 80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases. © 2021 The Authors, some rights reserved.
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- 2021
22. Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway
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García-Laorden MI, Hernández-Brito E, Munoz-Almagro C, Pavlovic-Nesic S, Rúa-Figueroa I, Briones ML, Rajas O, Borderías L, Payeras A, Lorente L, Freixinet J, Ferreres J, Obando I, González-Quevedo N, Rodríguez de Castro F, Solé-Violán J, and Rodríguez-Gallego C
- Subjects
MASP-2 ,collectin ,MBL ,lectin pathway ,primary immunodeficiency ,complement ,ficolin-3 - Abstract
Mannose-binding lectin (MBL)-associated serine protease-2 (MASP-2) is an indispensable enzyme for the activation of the lectin pathway of complement. Its deficiency is classified as a primary immunodeficiency associated to pyogenic bacterial infections, inflammatory lung disease, and autoimmunity. In Europeans, MASP-2 deficiency, due to homozygosity for c.359A > G (p.D120G), occurs in 7 to 14/10,000 individuals. We analyzed the presence of the p.D120G mutation in adults (increasing the sample size of our previous studies) and children. Different groups of patients (1495 adults hospitalized with community-acquired pneumonia, 186 adults with systemic lupus erythematosus, 103 pediatric patients with invasive pneumococcal disease) and control individuals (1119 healthy adult volunteers, 520 adult patients without history of relevant infectious diseases, and a pediatric control group of 311 individuals) were studied. Besides our previously reported MASP-2-deficient healthy adults, we found a new p.D120G homozygous individual from the pediatric control group. We also reviewed p.D120G homozygous individuals reported so far: a total of eleven patients with a highly heterogeneous range of disorders and nine healthy controls (including our four MASP-2-deficient individuals) have been identified by chance in association studies. Individuals with complete deficiencies of several pattern recognition molecules of the lectin pathway (MBL, collectin-10 and collectin-11, and ficolin-3) as well as of MASP-1 and MASP-3 have also been reviewed. Cumulative evidence suggests that MASP-2, and even other components of the LP, are largely redundant in human defenses and that individuals with MASP-2 deficiency do not seem to be particularly prone to infectious or autoimmune diseases.
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- 2020
23. Pneumococcal pneumonia coinfection in critically ill patients with influenza a (h1n1) primary viral pneumonia
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González De Molina, FJ, Rodríguez, A, Barbadillo, S, Díaz, E, Solé-Violán, J, Socias, L, Vergara, JC, Zaragoza, R, Suberviola, B, Vidaur, L, Ferrer, R, Martín-Loeches, I, and SEMICYUC/GETGAG Working Group
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- 2015
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24. Variabilidad genética en la susceptibilidad y en la gravedad de la neumonía
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Rodríguez de Castro, F., Solé-Violán, J., and Rodríguez-Gallego, J.C.
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- 2005
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25. Treatment of Ventilator-Associated Pneumonia
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Solé-Violán, J., primary and Rodríguez de Castro, F., additional
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- 2001
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26. Role of mannose-binding lectin on pneumococcal infections
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Solé Violán, J, García-Laorden, I, Rodríguez de Castro, F, Payeras, A, Ferrer Agüero, J, Briones, M, Borderías, L, Aspa, J, Blanquer, J, Rajas, O, García-Bello, M, Noda, J, Rello, J, and Rodríguez Gallego, C
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- 2012
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27. Influence of TIMP-1/MMP-9 ratio on the severity and mortality in sepsis
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Lorente, L, Martín, MM, Solé-Violán, J, Blanquer, J, Labarta, L, Díaz, C, Borreguero-León, JM, and Páramo, JA
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- 2011
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28. Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection
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Rodríguez A, Reyes LF, Monclou J, Suberviola B, Bodí M, Sirgo G, Solé-Violán J, Guardiola J, Barahona D, Díaz E, Martín-Loeches I, Restrepo MI, on behalf GETGAG study group, and GETGAG study group
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- 2018
29. Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016
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Author et al, Bateman, RM, Sharpe, MD, Jagger, JE, Ellis, CG, Solé-Violán, J, López-Rodríguez, M, Herrera-Ramos, E, Ruíz-Hernández, J, Borderías, L, Horcajada, J, González-Quevedo, N, Rajas, O, Briones, M, Rodríguez de Castro, F, Rodríguez Gallego, C, Esen, F, Orhun, G, Ergin Ozcan, P, Senturk, E, Ugur Yilmaz, C, Orhan, N, Arican, N, Kaya, M, Kucukerden, M, Giris, M, Akcan, U, Bilgic Gazioglu, S, Tuzun, E, Riff, R, Naamani, O, Douvdevani, A, Takegawa, R, Yoshida, H, Hirose, T, Yamamoto, N, Hagiya, H, Ojima, M, Akeda, Y, Tasaki, O, Tomono, K, Shimazu, T, Ono, S, Kubo, T, Suda, S, Ueno, T, Ikeda, T, Ogura, H, Takahashi, H, Kang, J, Nakamura, Y, Kojima, T, Izutani, Y, Taniguchi, T, O, M, Dinter, C, Lotz, J, Eilers, B, Wissmann, C, Lott, R, Meili, MM, Schuetz, PS, Hawa, H, Sharshir, M, Aburageila, M, Salahuddin, N, Chantziara, V, Georgiou, S, Tsimogianni, A, Alexandropoulos, P, Vassi, A, Lagiou, F, Valta, M, Micha, G, Chinou, E, Michaloudis, G, Kodaira, A, Imaizumi, H, De la Torre-Prados, MV, Garcia-De la Torre, A, Enguix-Armada, A, Puerto-Morlan, A, Perez-Valero, V, Garcia-Alcantara, A, Bolton, N, Dudziak, J, Bonney, S, and Tridente, A
- Subjects
Good Health and Well Being ,Medical and Health Sciences ,Emergency & Critical Care Medicine - Abstract
[This corrects the article DOI: 10.1186/s13054-016-1208-6.].
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- 2016
30. Decrease in Mortality in Severe Community-Acquired Pneumococcal Pneumonia Impact of Improving Antibiotic Strategies (2000-2013)
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Gattarello S, Borgatta B, Solé-Violán J, Vallés J, Vidaur L, Zaragoza R, Torres A, and Rello J
- Abstract
OBJECTIVE: The objective of the present study was to compare antibiotic prescribing practices and survival in the ICU for patients with pneumococcal severe community-acquired pneumonia (SCAP) between 2000 and 2013. METHODS: This was a matched case-control study of two prospectively recorded cohorts in Europe. Eighty patients from the Community-Acquired Pneumonia en la Unidad de Cuidados Intensivos (CAPUCI) II study (case group) were matched with 80 patients from CAPUCI I (control group) based on the following: shock at admission, need of mechanical ventilation, COPD, immunosuppression, and age. RESULTS: Demographic data were comparable in the two groups. Combined antibiotic therapy increased from 66.2% to 87.5% (P < .01), and the percentage of patients receiving the first dose of antibiotic within 3 h increased from 27.5% to 70.0% (P < .01). ICU mortality was significantly lower (OR, 0.82; 95% CI, 0.68-0.98) in cases, both in the whole population and in the subgroups of patients with shock (OR, 0.67; 95% CI, 0.50-0.89) or receiving mechanical ventilation (OR, 0.73; 95% CI, 0.55-0.96). In the multivariate analysis, ICU mortality increased in patients requiring mechanical ventilation (OR, 5.23; 95% CI, 1.60-17.17) and decreased in patients receiving early antibiotic treatment (OR, 0.36; 95% CI, 0.15-0.87) and combined therapy (OR, 0.19; 95% CI, 0.07-0.51). CONCLUSIONS: In pneumococcal SCAP, early antibiotic prescription and use of combination therapy increased. Both were associated with improved survival.
- Published
- 2014
31. Sustained high serum caspase-3 concentrations and mortality in septic patients.
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Lorente, L., Martín, M. M., Pérez-Cejas, A., González-Rivero, A. F., López, R. O., Ferreres, J., Solé-Violán, J., Labarta, L., Díaz, C., Palmero, S., and Jiménez, A.
- Subjects
CASPASES ,SEPSIS ,APOPTOSIS ,MORTALITY ,MANN Whitney U Test ,PATIENTS - Abstract
Caspase-3 is the main executor of the apoptotic process. Higher serum caspase-3 concentrations in non-survivor compared to survivor septic patients have been found. The objectives of this work (with the increase of sample size to 308 patients, and the determination of serum caspase-3 concentrations also on days 4 and 8 of diagnosis of severe sepsis) were to know whether an association between serum caspase-3 concentrationss during the first week, degree of apoptosis, sepsis severity, and sepsis mortality exists. We collected serum samples of 308 patients with severe sepsis from eight intensive care units on days 1, 4 and 8 to measure concentrations of caspase-3 and caspase-cleaved cytokeratin (CCCK)-18 (to assess degree of apoptosis). End point was 30-day mortality. We found higher serum concentrations of caspase-3 and CCCK-18 in non-survivors compared to survivors on days 1 (p < 0.001), 4 (p < 0.001), and 8 (p < 0.001). We found an association between serum caspase-3 concentrations on days 1, 4 and 8 of severe sepsis diagnosis and serum CCCK-18 concentrations (p < 0.001), SOFA (p < 0.001), serum acid lactic concentrations (p < 0.001), and 30-day sepsis mortality (p < 0.001). The new findings of this work were that an association between serum caspase-3 concentrations during the first week, apoptosis degree, sepsis severity, and sepsis mortality exists. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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32. Bilateral cerebral infarction secondary to traumatic carotid artery dissection
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Ferrer Agüero, J.M., Pardo Moreno, D., and Solé Violán, J.
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- 2012
33. Neumonía adquirida en la comunidad: variantes génicas implicadas en la inflamación sistémicamación sistémica
- Author
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Ferrer Agüero, J.M., primary, Millán, S., additional, Rodríguez de Castro, F., additional, Martín-Loeches, I., additional, and Solé Violán, J., additional
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- 2014
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34. Community acquired pneumonia: Genetic variants influencing systemic inflammation
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Ferrer Agüero, J.M., primary, Millán, S., additional, Rodríguez de Castro, F., additional, Martín-Loeches, I., additional, and Solé Violán, J., additional
- Published
- 2014
- Full Text
- View/download PDF
35. Impact of quantitative invasive diagnostic techniques in the management and outcome of mechanically ventilated patients with suspected pneumonia.
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Solé Violán J, Arroyo Fernández J, Bordes Benítez A, Cardeñosa Cendrero JA, Rodríguez de Castro F, Solé Violán, J, Fernández, J A, Benítez, A B, Cardeñosa Cendrero, J A, and Rodríguez de Castro, F
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- 2000
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36. Infarto cerebral bilateral tras disección carotídea traumática
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Ferrer Agüero, J.M., primary, Pardo Moreno, D., additional, and Solé Violán, J., additional
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- 2012
- Full Text
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37. Recommendations of the Infectious Diseases Work Group (GTEI) of the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) and the Infections in Critically Ill Patients Study Group (GEIPC) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) for the diagnosis and treatment of influenza A/H1N1 in seriously ill adults admitted to the Intensive Care Unit
- Author
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Rodríguez, A., primary, Álvarez-Rocha, L., additional, Sirvent, J.M., additional, Zaragoza, R., additional, Nieto, M., additional, Arenzana, A., additional, Luque, P., additional, Socías, L., additional, Martín, M., additional, Navarro, D., additional, Camarena, J., additional, Lorente, L., additional, Trefler, S., additional, Vidaur, L., additional, Solé-Violán, J., additional, Barcenilla, F., additional, Pobo, A., additional, Vallés, J., additional, Ferri, C., additional, Martín-Loeches, I., additional, Díaz, E., additional, López, D., additional, López-Pueyo, M.J., additional, Gordo, F., additional, del Nogal, F., additional, Marqués, A., additional, Tormo, S., additional, Fuset, M.P., additional, Pérez, F., additional, Bonastre, J., additional, Suberviola, B., additional, Navas, E., additional, and León, C., additional
- Published
- 2012
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38. Recomendaciones del Grupo de Trabajo Enfermedades Infecciosas (GTEI) de la Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (SEMICYUC) y el Grupo de Estudio de Infecciones en el Paciente Crítico (GEIPC) de la Sociedad Española de Enfermedades Infecciosas y Microbiología clínica (SEIMC) para el diagnóstico y tratamiento de la gripe A/H1N1 en pacientes adultos graves hospitalizados en las Unidades de Cuidados Intensivos
- Author
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Rodríguez, A., primary, Álvarez-Rocha, L., additional, Sirvent, J.M., additional, Zaragoza, R., additional, Nieto, M., additional, Arenzana, A., additional, Luque, P., additional, Socías, L., additional, Martín, M., additional, Navarro, D., additional, Camarena, J., additional, Lorente, L., additional, Trefler, S., additional, Vidaur, L., additional, Solé-Violán, J., additional, Barcenilla, F., additional, Pobo, A., additional, Vallés, J., additional, Ferri, C., additional, Martín-Loeches, I., additional, Díaz, E., additional, López, D., additional, López-Pueyo, M.J., additional, Gordo, F., additional, del Nogal, F., additional, Marqués, A., additional, Tormo, S., additional, Fuset, M.P., additional, Pérez, F., additional, Bonastre, J., additional, Suberviola, B., additional, Navas, E., additional, and León, C., additional
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- 2012
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39. Nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureustreated with linezolid or vancomycin: A secondary economic analysis of resource use from a Spanish perspective
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Rello, J., Nieto, M., Solé-Violán, J., Wan, Y., Gao, X., Solem, C.T., De Salas-Cansado, M., Mesa, F., Charbonneau, C., and Chastre, J.
- Abstract
Adopting a unique Spanish perspective, this study aims to assess healthcare resource utilization (HCRU) and the costs of treating nosocomial pneumonia (NP) produced by methicillin-resistant Staphylococcus aureus(MRSA) in hospitalized adults using linezolid or vancomycin. An evaluation is also made of the renal failure rate and related economic outcomes between study groups.
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- 2016
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40. Infecciones comunitarias que requieren ingreso en UCI
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Blanquer, J., primary, Solé-Violán, J., additional, Carvajal, J., additional, and Lucena, F., additional
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- 2010
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41. Influence of TIMP-1/MMP-9 ratio on the severity and mortality in sepsis
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Lorente, L, primary, Martín, M, additional, Solé-Violán, J, additional, Blanquer, J, additional, Labarta, L, additional, Díaz, C, additional, Borreguero, J, additional, and Páramo, J, additional
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- 2010
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42. Genetic variability at the surfactant proteins A and D in susceptibility and severity of pneumonia
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Solé-Violán, J, primary, Garcia-Laorden, M, additional, Rodriguez de Castro, F, additional, Rajas, O, additional, Blanquer, J, additional, Borderías, L, additional, Saavedra, P, additional, Aspa, J, additional, Briones, M, additional, Marcos-Ramos, J, additional, Herrera-Ramos, E, additional, Ferrer, J, additional, Sologuren, I, additional, Rello, J, additional, and Rodriguez-Gallego, C, additional
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- 2010
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43. Epidemiology and outcome of patients with severe sepsis in six Spanish ICUs
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Lorente, L, primary, Martín, M, additional, Díaz, C, additional, Labarta, L, additional, Ferreres, J, additional, Solé-Violán, J, additional, Borreguero, J, additional, and Barrios, Y, additional
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- 2009
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44. Role of 4G/5G plasminogen activator inhibitor-1 (PAI-1) gene polymorphism and the PAI-1 plasma levels in the outcome of patients with severe sepsis
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Lorente, L, primary, Martín, M, additional, Labarta, L, additional, Díaz, C, additional, Solé-Violán, J, additional, Blanquer, J, additional, Borreguero, J, additional, and Barrios, Y, additional
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- 2009
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45. Viabilidad y reproducibilidad de la posición semisentada para prevenir la neumonía asociada a la ventilación mecánica
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Solé Violán, J., primary, Ferrer Agüero, J.M., additional, and Rodríguez de Castro, F., additional
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- 2007
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46. Viejos y nuevos antibióticos en neumología
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Rodríguez de Castro, F., primary and Solé Violán, J., additional
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- 1997
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47. Utilidad de las fibras de elastina como marcador diagnóstico de la neumonía asociada al ventilador
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Rodríguez de Castro, F., primary, Acosta Fernández, O., additional, Caminero Luna, J.A., additional, Cabrera Navarro, P., additional, Solé Violán, J., additional, Rey López, A., additional, and Martín González, J.C., additional
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- 1994
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48. The Fc[gamma] receptor IIA-H/H131 genotype is associated with bacteremia in pneumococcal community-acquired pneumonia.
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Solé-Violán J, García-Laorden MI, Marcos-Ramos JA, de Castro FR, Rajas O, Borderías L, Briones ML, Herrera-Ramos E, Blanquer J, Aspa J, Florido Y, García-Bello MA, Ferrer-Agüero JM, Sologuren I, and Rodriguez-Gallego C
- Abstract
OBJECTIVE: To assess the potential association of the functional polymorphism rs1801274 in the receptor IIa for the Fc portion of immunoglobin G (Fc[gamma]RIIa) gene (FCGR2A-H131R) with the susceptibility to and the severity of community-acquired pneumonia (CAP). DESIGN: Multicenter prospective and observational study. SETTING: Four university hospitals in Spain. PATIENTS: FCGR2A-H131R polymorphism was determined in 1,262 patients with CAP and in 1,224 in the subject control group. MEASUREMENTS AND MAIN RESULTS: Severe sepsis was recorded in 366 patients. No significant differences in genotype or allele frequencies were seen among patients with CAP or pneumococcal CAP (PCAP) and controls. Patients with bacteremic PCAP (B-PCAP) had significantly higher frequencies of FCGR2A-H/H131 genotypes than those with nonbacteremic PCAP (p = .00016, odds ratio = 2.9, 95% confidence interval 1.58-5.3). The differences remained significant when adjusting for pneumonia severity index, hospital of origin, and intensive care unit admission (p = .0012, odds ratio = 2.83, 95% confidence interval 1.51-5.32). B-PCAP was associated with a significantly higher severity of the disease, evaluated as sepsis severity (p = .000007, odds ratio = 4.40, 95% confidence interval 2.31-8.39), multiorgan dysfunction syndrome (0.00048, odds ratio = 3.29, 95% confidence interval 1.69-6.41), intensive care unit admission, acute renal failure, and acute respiratory distress syndrome. CONCLUSIONS: Our results do not support a role of FCGR2A-H131R polymorphism in susceptibility to CAP or PCAP. However, we provide the insight that homozygosity for FCGR2A-H131 predisposes B-PCAP, which was associated with higher severity in our study. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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49. Platelet cytochrome c oxidase activity and quantity in septic patients.
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Lorente L, Martín MM, López-Gallardo E, Iceta R, Solé-Violán J, Blanquer J, Labarta L, Díaz C, Jiménez A, Lafuente N, Hernández M, Méndez F, Medina N, Ferrer-Agüero JM, Ferreres J, LLimiñana MC, Mora ML, Lubillo S, Sánchez-Palacios M, and Montoya J
- Published
- 2011
- Full Text
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50. Impact of nonexacerbated COPD on mortality in critically ill patients.
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Rodríguez A, Lisboa T, Solé-Violán J, Gómez F, Roca O, Trefler S, Gea J, Masclans JR, Rello J, Rodríguez, Alejandro, Lisboa, Thiago, Solé-Violán, Jorge, Gómez, Federico, Roca, Oriol, Trefler, Sandra, Gea, Joaquim, Masclans, Joan R, and Rello, Jordi
- Abstract
Background: The real contribution of nonexacerbated COPD to mortality has not been studied. The aim of our study was to evaluate the impact of nonexacerbated COPD on mortality in patients requiring mechanical ventilation (MV).Methods: This prospective, observational study included critically ill, ventilated patients without evidence of respiratory infection. Patients with COPD comprised the study group. Clinical and demographics variables were recorded. The main end point was ICU mortality.Results: Of the 235 patients included, 60 (25.5%) intubated patients had COPD. The remaining 175 (74.5%) comprised the control group. Those with COPD were more often medical patients who were older and had a higher number of comorbidities and a higher APACHE (Acute Physiology and Chronic Health Evaluation) II score than intubated patients without COPD (P < .05). The overall ICU mortality was 26.3% (62/235) and significantly higher in patients with nonexacerbated COPD (36.7% vs 22.9%, P < .05), with an attributable mortality to COPD of 13.8%. Incidence of ventilator-associated pneumonia was not significantly different between patients with nonexacerbated COPD (11.9/1,000 MV days) and without COPD (16.0/1,000 MV days; P = .40). In the multivariate analysis, only COPD (hazard ratio [HR], 2.1; 95% CI, 1.10-3.94), shock at ICU admission (HR, 2.0; 95% CI, 1.01-4.01), and medical condition (HR, 1.7; 95% CI, 1.01-3.18) were independently associated with mortality.Conclusions: Intubated patients with nonexacerbated COPD were not exposed to a higher risk of ventilator-associated pneumonia but had a higher rate of mortality. [ABSTRACT FROM AUTHOR]- Published
- 2011
- Full Text
- View/download PDF
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