Search

Your search keyword '"Solárová, Zuzana"' showing total 21 results
Start Over Author "Solárová, Zuzana"
21 results on '"Solárová, Zuzana"'

12. Contributors

Author

Acharya, Debopam, Adnan, Mohammed, Alkandari, Dina, Azmi, Asfar S., Bala, Nandakishore, Baliga, Manjeshwar Shrinath, Bulbul, Md. Rakibul Hassan, Chakraborty, Sajib, Cho, Jae Hyun, Closs, Vera Elizabeth, Danko, Jan, Faris, Mo'ez Al-Islam E., Gottlieb, Maria Gabriela Valle, Gupta, Pankaj, Hadi, Sheikh Mumtaz, Han, Youngjin, Huq, Fazlul, Islam, S.M. Rafiqul, Itharat, Arunporn, Junges, Vilma Maria, Kabir, Yearul, Kalekhan, Faizan, Kello, Martin, Khaleque, Md. Abdul, Khan, Husain Y., Kubatka, Peter, Kudva, Avinash Kundadka, Lazim, Norhafiza Mat, Lee, Ki Won, Liskova, Alena, Martinotti, Simona, Moffatt, Robert, Mohammad, Mohammad G., Mohammad, Ramzi M., Mojzis, Jan, Nessa, Meher Un, Olivas-Aguirre, Francisco J., Pai, Karkala Sreedhara Ranganath, Pais, Michael L.J., Park, In Sil, Rahman, Mohammad Mostafizur, Rahman, Md. Atiar, Rahman, Atiqur, Ranzato, Elia, Rao, Suresh, Rao, Pratima, Ray, Amitabha, Sajan, Simon, Seibel, Raquel, Sharma, Rakesh, Siddiqua, Towfida Jahan, Sidhu, Jiwan S., Solar, Peter, Solarova, Zuzana, Soliman, Sameh, Song, Yong Sang, Trivedi, Arvind, Varol, Mehmet, Wall-Medrano, Abraham, Zafar, Tasleem A., Zubor, Pavol, and Zulli, Anthony

Published
2020
Full Text
View/download PDF

18. Erythropoietin and Ovarian Cancer – Response

Author

Solár, Peter, primary, Koval, Ján, additional, Mikeš, Jaromír, additional, Kleban, Ján, additional, Solárová, Zuzana, additional, Lazúr, Ján, additional, Hodorová, Ingrid, additional, Fedoročko, Peter, additional, and Sytkowski, Arthur J., additional

Published
2010
Full Text
View/download PDF

21. Location and the functionality of erythropoietin receptor(s) in A2780 cells.

Author

Solár P, Hrčková G, Varinská L, Solárová Z, Kriška J, Uhrínová I, Kello M, Mojžiš J, Fedoročko P, and Sytkowski AJ

Subjects
Cell Line, Tumor, Cell Membrane metabolism, Cell Proliferation, Endoplasmic Reticulum metabolism, Erythropoietin physiology, Female, Gene Knockdown Techniques, Humans, Intracellular Membranes metabolism, Microscopy, Fluorescence, Mitogen-Activated Protein Kinase 1 metabolism, Mitogen-Activated Protein Kinase 3 metabolism, Ovarian Neoplasms, Phosphorylation, Proto-Oncogene Proteins c-akt metabolism, RNA Interference, Receptors, Erythropoietin genetics, Receptors, Erythropoietin metabolism, Secretory Vesicles metabolism, Receptors, Erythropoietin physiology
Abstract

Erythropoietin (Epo) is a critical regulator of erythroid cell proliferation, differentiation and apoptosis. In the form of a recombinant protein, it is widely used to treat various forms of anemia, including that associated with cancer and with the myelosuppressive effects of chemotherapy. Studies of ovarian cancer cell lines have demonstrated the presence of the Epo receptor (EpoR), but there are disagreements regarding its localization and functionality in these cells. Using fluorescence microscopy, we were not able to identify the EpoR on the surface of A2780 cells, in contrast to the positive control K562 cells. Flow cytometry did reveal a weak surface EpoR signal in A2780 cells. Interestingly, most of the EpoR in A2780 cells was found in the cytoplasm, more abundantly as an intracellular membrane-associated protein than a soluble one. Silencing EpoR expression by lentiviral-mediated shRNA resulted in reduced A2780 proliferation as well as reduction in Epo-induced phosphorylation of Erk1/2. Our findings provide important insights into the biology of the EpoR in ovarian cancer cells.

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results