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1. Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-2: Specific Entities, Risk Stratification and Challenges After Recovery).

Author

Yalta, Kenan, Madias, John E., Kounis, Nicholas G., Y-Hassan, Shams, Polovina, Marija, Altay, Servet, Mebazaa, Alexandre, Yilmaz, Mehmet Birhan, Lopatin, Yuri, Mamas, Mamas A., Gil, Robert J., Thamman, Ritu, Almaghraby, Abdallah, Bozkurt, Biykem, Bajraktari, Gani, Fink, Thomas, Traykov, Vassil, Manzo-Silberman, Stephane, Mirzoyev, Ulvi, and Sokolovic, Sekib

Subjects
CONSENSUS (Social sciences), RISK assessment, TAKOTSUBO cardiomyopathy, CONVALESCENCE, DISEASE relapse, BIOMARKERS, DISEASE risk factors, SYMPTOMS
Abstract

Takotsubo syndrome (TTS) still remains as an enigmatic phenomenon. In particular, long-term challenges (including clinical recurrence and persistent symptoms) and specific entities in the setting of TTS have been the evolving areas of interest. On the other hand, a significant gap still exists regarding the proper risk-stratification of this phenomenon in the short and long terms. The present paper, the second part (part-2) of the consensus report, aims to discuss less well-known aspects of TTS including specific entities, challenges after recovery and risk-stratification. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-1: Diagnostic and Therapeutic Challenges).

Author

Yalta, Kenan, Madias, John E., Kounis, Nicholas G., Y-Hassan, Shams, Polovina, Marija, Altay, Servet, Mebazaa, Alexandre, Yilmaz, Mehmet Birhan, Lopatin, Yuri, Mamas, Mamas A., Gil, Robert J., Thamman, Ritu, Almaghraby, Abdallah, Bozkurt, Biykem, Bajraktari, Gani, Fink, Thomas, Traykov, Vassil, Manzo-Silberman, Stephane, Mirzoyev, Ulvi, and Sokolovic, Sekib

Subjects
CONSENSUS (Social sciences), TAKOTSUBO cardiomyopathy, ELECTROCARDIOGRAPHY
Abstract

In the recent years, there has been a burgeoning interest in Takotsubo syndrome (TTS), which is renowned as a specific form of reversible myocardial dysfunction. Despite the extensive literature available on TTS, clinicians still face several practical challenges associated with the diagnosis and management of this phenomenon. This potentially results in the underdiagnosis and improper management of TTS in clinical practice. The present paper, the first part (part-1) of the consensus report, aims to cover diagnostic and therapeutic challenges associated with TTS along with certain recommendations to combat these challenges. [ABSTRACT FROM AUTHOR]

Published
2024
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4. The Patterns of Non-vitamin K Antagonist Oral Anticoagulants (NOACs) Use in Patients with Atrial Fibrillation in Seven Balkan Countries: a Report from the BALKAN-AF Survey

Author

Potpara, Tatjana S., Trendafilova, Elina, Dan, Gheorghe-Andrei, Goda, Artan, Kusljugic, Zumreta, Manola, Sime, Music, Ljilja, Gjini, Viktor, Pojskic, Belma, Popescu, Mircea Ioakim, Georgescu, Catalina Arsenescu, Dimitrova, Elena S., Kamenova, Delyana, Ekmeciu, Uliks, Mrsic, Denis, Nenezic, Ana, Brusich, Sandro, Milanov, Srdjan, Zeljkovic, Ivan, Lip, Gregory Y. H., Dan, Gheorghe-Andrei, Musetescu, Rodica, Popescu, Mircea Ioachim, Badila, Elisabeta, Arsenescu Georgescu, Catalina, Pop, Sorina, Popescu, Raluca, Neamtu, Simina, Oancea, Floriana, Dan, Anca Rodica, Potpara, Tatjana, Polovina, Marija, Milanov, Srdjan, Mitic, Gorana, Milanov, Marko, Savic, Jelena, Markovic, Snezana, Koncarevic, Ivana, Gavrilovic, Jelena, Pavlovic, Marija, Djikic, Dijana, Petrovic, Marijana, Simovic, Stefan, Malic, Semir, Hodzic, Jusuf, Stojanovic, Milovan, Gnip, Sanja, Zlatar, Milan, Matic, Dragan, Lazic, Snezana, Acimovic, Tijana, Radovic, Pavica, Peric, Vladan, Markovic, Sanja, Kovacevic, Snezana, Arandjelovic, Aleksandra, Asanin, Milika, Nedeljkovic, Milan M., Zdravkovic, Marija, Deljanin Ilic, Marina, Trendafilova, Elina, Dimitrova, Elena, Petranov, Stanislav, Kamenova, Delyana, Kamenova, Penka, Elefterova, Svetoslava, Shterev, Valentin, Zekova, Maria, Diukiandzhieva, Stela, Goshev, Evgenii, Dimitrov, Boiko, Sotirov, Tihomir, Simeonova, Valentina, Velichkova, Anna, Drianovska, Dimitrina, Vasileva Boiadzhieva, Liliya Ivanova, Buchukova, Darina, Goda, Artan, Paparisto, Vilma, Gjini, Viktor, Ekmekciu, Uliks, Gjergo, Hortensia, Mijo, Alma, Shirka, Ervina, Refatllari, Ina, Kusljugic, Zumreta, Loncar, Daniela, Pojskic, Belma, Mrsic, Denis, Sijamija, Alma, Bijedic, Amira, Bijedic, Irma, Karamujic, Indira, Halilovic, Sanela, Tulumovic, Hazim, Sokolovic, Sekib, Manola, Sime, Brusich, Sandro, Zeljkovic, Ivan, Anic, Ante, Pavlovic, Nikola, Radeljic, Vjekoslav, Jeric, Melita, Pekic, Petar, Milas, Kresimir, Music, Ljilja, Nenezic, Ana, Bulatovic, Nebojsa, Asanovic, Dijana, and On behalf of the BALKAN-AF Investigators

Published
2017
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5. Differences and similarities in rheumatology specialty training programmes across European countries

Author

Sivera, Francisca, Ramiro, Sofia, Cikes, Nada, Dougados, Maxime, Gossec, Laure, Kvien, Tore K, Lundberg, Ingrid E, Mandl, Peter, Moorthy, Arumugam, Panchal, Sonia, da Silva, José A P, Bijlsma, Johannes W, Collaku, Ledio, Aroyan, Armine, Radner, Helga, Tushina, Anastasyia, De Langhe, Ellen, Sokolovic, Sekib, Shumnalieva, Russka, Baresic, Marko, Senolt, Ladislav, Holland-Fischer, Mette, Kull, Mart, Puolitaival, Antti, Letsveridze, Khatuna, Hueber, Axel, Fanouriakis, Antonis, MacMullan, Paul, Rimar, Doron, Bugatti, Serena, Zepa, Julija, Menasssa, Jeanine, Karpec, Diana, Misevska-Percinkova, Snezana, Cassar, Karen, Deseatnicova, Elena, Tas, Sander, Haavardsholm, Espen, Sznajd, Jan, Berghea, Florian, Trifonova, Elena, Jeremic, Ivica, Mlynarikova, Vanda, Frank-Bertoncelj, Mojca, Chatzidionysiou, Aikaterina, Dumusc, Alexandre, Hatemi, Gulen, Ozdemirel, Erhan, and Biliavska, Iuliia

Published
2015
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7. Variations in criteria regulating treatment with reimbursed biologic DMARDs across European countries. Are differences related to countryʼs wealth?

Author

Putrik, Polina, Ramiro, Sofia, Kvien, Tore K, Sokka, Tuulikki, Uhlig, Till, Boonen, Annelies, Collaku, Ledio, Harutyunyan, Ruzanna, Radner, Helga, Soroka, Nikolay, Mielants, Herman, Sokolovic, Sekib, Sapundzhiev, Lyubomir, Mayer, Miroslav, Charalambous, Paraskevi, Vencovsky, Jiri, Hetland, Merete Lund, Peets, Tõnu, Fautrel, Bruno, Letsveridze, Khatuna, Müller-Ladner, Ulf, Sidiropoulos, Prodromos, Péntek, Márta, Gröndal, Gerdur, McGrehan, Fiona, Bruno, Seriolo, Galymzhan, Togizbayev, Andersone, Daina, Butrimiene, Irena, Hirsch, Marco, Misevska-Percinkova, Snezana, Cassar, Karen, Deseatnicova, Elena, Mustur, Dusan, Raciborski, Filip, Tavares, Viviana, Berghea, Florian, Shirinsky, Ivan, Veljkovic, Miodrag, Kovarova, Maria, Tomsic, Matija, Sivera, Francisca, Petersson, Ingemar, Finckh, Axel, Sharipov, Shaydullo, Inanc, Nevsun, Dumenko, Tatyana, Verstappen, Suzanne, and Khudoberdiev, Hojimurad

Published
2014
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8. Inequities in access to biologic and synthetic DMARDs across 46 European countries

Author

Putrik, Polina, Ramiro, Sofia, Kvien, Tore K, Sokka, Tuulikki, Pavlova, Milena, Uhlig, Till, Boonen, Annelies, Tafaj, Argjent, Harutyunyan, Ruzanna, Radner, Helga, Soroka, Nikolay, Mielants, Herman, Sokolovic, Sekib, Lambova, Sevdalina, Mayer, Miroslav, Charalambous, Paraskevi, Vencovsky, Jiri, Hetland, Merete Lund, Peets, Tõnu, Fautrel, Bruno, Letsveridze, Khatuna, Müller-Ladner, Ulf, Sidiropoulos, Prodromos, Péntek, Márta, Gröndal, Gerdur, FitzGerald, Oliver, Bruno, Seriolo, Togizbayev, Galimzhan, Andersone, Daina, Butrimienė, Irena, Hirsch, Marco, Misevska-Percinkova, Snezana, Cassar, Karen, Deseatnicova, Elena, Mustur, Dusan, Głuszko, Piotr, Tavares, Viviana, Berghea, Florian, Shirinsky, Ivan, Veljkovic, Miodrag, Rovensky, Jozef, Tomsic, Matija, Sivera, Francisca, Petersson, Ingemar F., Axel, Finckh, Shaydullo, Sharipov, Inanc, Nevsun, Dumenko, Tatyana, Verstappen, Suzanne, and Khudoberdiev, Hojimurad

Published
2014
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9. EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis

Author

Colebatch, Alexandra N, Edwards, Christopher John, Østergaard, Mikkel, van der Heijde, Désirée, Balint, Peter V, DʼAgostino, Maria-Antonietta, Forslind, Kristina, Grassi, Walter, Haavardsholm, Espen A, Haugeberg, Glenn, Jurik, Anne-Grethe, Landewé, Robert BM, Naredo, Esperanza, OʼConnor, Philip J, Ostendorf, Ben, Potočki, Kristina, Schmidt, Wolfgang A, Smolen, Josef S, Sokolovic, Sekib, Watt, Iain, and Conaghan, Philip G

Published
2013
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11. May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Author

Beaney, Thomas, Burrell, Louise M, Castillo, Rafael R, Charchar, Fadi J, Cro, Suzie, Damasceno, Albertino, Kruger, Ruan, Nilsson, Peter M, Prabhakaran, Dorairaj, Ramirez, Agustin J, Schlaich, Markus P, Schutte, Aletta E, Tomaszewski, Maciej, Touyz, Rhian, Wang, Ji-Guang, Weber, Michael A, Poulter, Neil R, Burazeri, Genc, Qirjako, Gentiana, Roshi, Enver, Cunashi, Rudina, Fernandes, Mario J C C, Victória Pereira, Savarino S, Neto, Marisa F M P, Oliveira, Pombalino N M, Feijão, Ana C G, Cerniello, Yamila, Marin, Marcos J, Garcia Vasquez, Fortunato, Espeche, Walter G, Stisman, Diego, Fuentes, Inés A, Zilberman, Juith M, Rodriguez, Pablo, Babinyan, Kamsar Yu, Engibaryan, Anna H, Avagyan, Avag M, Minasyan, Arsen A, Gevorkyan, Ani T, Carnagarin, Revathy, Carrington, Melinda J, Sharman, James E, Lee, Rebecca, Perl, Sabine, Niederl, Ella, Malik, Fazila-Tun-Nesa, Choudhury, Sohel R, Al Mamun, Mohammad A, Ishraquzzaman, Mir, Anthony, Fiona, Connell, Kenneth, De Backer, Tine L M, Krzesinski, Jea, Houenassi, Martin D, Houehanou, Corine Y, Sokolovic, Sekib, Bahtijarevic, Rankica, Tiro, Mary B, Mosepele, Mosepele, Masupe, Tiny K, Barroso, Weimar S, Gomes, Marco A M, Feitosa, Audes D M, Brandão, Andrea A, Miranda, Roberto D, Azevedo, Vanda M A A, Dias, Luis M, Garcia, Glenda D N, Martins, Idiana P P, Dzudie, Anastase, Kingue, Samuel, Djomou, Florent A N, Njume, Epie, Khan, Nadia, Lanas, Fernando T, Garcia, Maria S, Paccot, Melanie F, Torres, Pamela I, Li, Yan, Liu, Min, Xu, Liying, Li, Li, Chen, Xin, Deng, Junping, Zhao, Wenwu, Fu, Lingjuan, Zhou, Yi, Lopez-Jaramillo, Patricio, Otero, Johanna, Camacho, Paul A, Accini, Jose L, Sanchez, Gregorio, Arcos, Edgar, M’Buyamba-Kabangu, Jean-René, Katamba, Fortunat K, Ngoyi, Georges N, Buila, Nathan M, Bayauli, Pascal M, Ellenga Mbolla, Bertrand F, Bakekolo, Paterne R, Kouala Landa, Christian M, Kimbally Kaky, Gisele S, Kramoh, Euloge K, Ngoran, Yves N K, Olsen, Michael H, Valdez Valoy, Laura, Santillan, Marcos, Angel Rafael, Gonzalez Medina, Peñaherrera, Carlos E, Villalba, Jose, Ramirez, Maria I, Arteaga, Fabricio, Delgado, Patricia, Beistline, Holly, Cappuccio, Francesco P, Keitley, James, Tay, Tricia, Goshu, Dejuma Y, Kassie, Desalew M, Gebru, Sintayehu A, Pathak, Atul, Denolle, Thierry, Tsinamdzgvrishvili, Bezhan, Trapaidze, Dali, Sturua, Lela, Abesadze, Tamar, Grdzelidze, Nino, Grabfelder, Mark, Krämer, Bernhard K, Schmeider, Roland E, Twumasi-Ankrah, Betty, Tannor, Elliot K, Lincoln, Mary D, Deku, Enoch M, Wyss Quintana, Fernando S, Kenerson, John, Jean Baptiste, Emmanuela D, Saintilmond, Wideline W, Barrientos, Ana L, Peiger, Briggitte, Lagos, Ashley R, Forgas, Marcelo A, Lee, Vivian W Y, Tomlinson, Brian W Y, Járai, Zoltán, Páll, Dénes, More, Arun, Maheshwari, Anuj, Verma, Narsingh, Sharma, Meenakshi, Mukherjee, Tapan K, Patil, Mansi, Pulikkottil Jose, Arun, Takalkar, Anant, Turana, Yuda, Widyantoro, Bambang, Danny, Siska S, Djono, Suhar, Handari, Saskia D, Tambunan, Marihot, Tiksnadi, Badai B, Hermiawaty, Eka, Tavassoli, Elham, Zolfaghari, Mahsa, Dolan, Eamon, O'Brien, Eoin, Borghi, Claudio, Ferri, Claudio, Torlasco, Camilla, Parati, Gianfranco, Nwokocha, Chukwuemeka R, Nwokocha, Magdalene I, Ogola, Elijah N, Gitura, Bernard M, Barasa, Anders L, Barasa, Felix A, Wairagu, Anne W, Nalwa, Wafula Z, Najem, Robert N, Abu Alfa, Ali K, Fageh, Hatem A, Msalam, Omar M, Derbi, Hawa A, Bettamar, Kzaki A, Zakauskiene, Urte, Vickiene, Alvita, Calmes, Jessica, Alkerwi, Ala'a, Gantenbein, Manon, Ndhlovu, Henry L L, Masiye, Jones K, Chirwa, Maureen L, Nyirenda, Nancy M, Dhlamini, Tiyezge D, Chia, Yook C, Ching, Siew M, Devaraj, Navin K, Ouane, Nouhoum, Fane, Tidiani, Kowlessur, Sudhir, Ori, Bhooshun, Heecharan, Jaysing, Alcocer, Luis, Chavez, Adolfo, Ruiz, Griselda, Espinosa, Cutberto, Gomez-Alvarez, Enrique, Neupane, Dinesh, Bhattarai, Harikrishna, Ranabhat, Kamal, Adhikari, Tara B, Koirala, Sweta, Toure, Ibrahim A, Soumana, Kabirou H, Wahab, Kolawole W, Omotoso, Ayodele B, Sani, Mahmoud U, Okubadejo, Njideka U, Nadar, Sunil K, Al-Riyami, Hassan A, Ishaq, Mohammad, Memon, Feroz, Sidique, Sualat, Choudhry, Hafeez A, Khan, Rasheed A, Ayala, Myrian, Maidana, Angel J O, Bogado, Graciela GG, Ona, Deborah I, Atilano, Alberto, Granada, Carmela, Bartolome, Regina, Manese, Loudes, Mina, Arnold, Dumlao, Maria C, Villaruel, Mariyln C, Gomez, lynn, Jóźwiak, Jacek, Małyszko, Jolanta, Banach, Maciej, Mastej, Mirosław, de Carvalho Rodrigues, Manuel M, Martins, Luis L, Paval, Alexandra, Dorobantu, Maria, Konradi, Alexandra O, Chazova, Irina E, Rotar, Oxana, Spoares, Miryan C, Viegas, Deolsanik, Almustafa, Bader A, Alshurafa, Saleh A, Brady, Adrian, Bovet, Pascal, Viswanathan, Bharathi, Oladapo, Olulola O, Russell, James W, Brguljan-Hitij, Jana, Bozic, Nina, Knez, Judita, Dolenc, Primoz, Hassan, Mohammed M, Woodiwiss, Angela J, Myburgh, Caitlynd, Vally, Muhammed, Ruilope, Luis M, Molinero, Ana, Rodilla, Enrique, Gijón-Conde, Teresa, Beheiry, Hind M, Ali, I A, Osman, Asma A A, fahal, Naiema A W, Osman, Hana A, Altahir, Fatima, Persson, Margaretha, Wuerzner, Gregoire, Burkard, Thilo, Wang, Tzung-Dau, Lin, Hung-Ju, Pan, Heng-Yu, Chen, Wen-Jone, Lin, Eric, Mondo, Charles K, Ingabire, Prossie M, Khomazyuk, Tatyana TA, Krotova, Viktoriia V-Yu, Negresku, Elena, Evstigneeva, Olena, Bazargani, Nooshin NB, Agrawal, Amrish, Bin Belaila, Buthaina A, Suhail, Aisha M, Muhammed, Khalifa O, Shuri, Hassan H, Wainford, Richard D, Levy, Philip D, Boggia, José JG, Garré, Laura L, Hernandez-Hernandez, Rafael, Octavio-Seijas, Jose A, Lopez-Rivera, Jesus A, Morr, Igor, Duin, Amanda, Huynh, Minh V, Cao, Sinh T, Nguyen, Viet L, To, Muoi, Phan, Hung N, Cockroft, John, McDonnell, Barry, Goma, Fastone M, Syatalimi, Charity, Chifamba, Jephat, Gwini, Rudo, Tiburcio, Osiris Valdez, Xia, Xin, 20035632 - Kruger, Ruan, 10922180 - Schutte, Aletta Elisabeth, Beaney T., Burrell L.M., Castillo R.R., Charchar F.J., Cro S., Damasceno A., Kruger R., Nilsson P.M., Prabhakaran D., Ramirez A.J., Schlaich M.P., Schutte A.E., Tomaszewski M., Touyz R., Wang J.-G., Weber M.A., Poulter N.R., and Borghi C

Subjects
Male, Cardiac & Cardiovascular Systems, Cross-sectional study, Blood Pressure, 030204 cardiovascular system & hematology, Global Burden of Disease, 0302 clinical medicine, Surveys and Questionnaires, MMM Investigators, Mass Screening, 030212 general & internal medicine, 1102 Cardiorespiratory Medicine and Haematology, Antihypertensive medication, RISK, Global, Awareness, Middle Aged, PREVALENCE, Hypertension, Blood pressure, Screening, Raised blood pressure, Female, Cardiology and Cardiovascular Medicine, BURDEN, Life Sciences & Biomedicine, Control, Adult, medicine.medical_specialty, Fast Track Clinical Research, Opportunistic Sampling, 03 medical and health sciences, Internal medicine, medicine, SYSTEMATIC ANALYSIS, MANAGEMENT, Humans, Mass screening, Disease burden, Antihypertensive Agents, Science & Technology, business.industry, Case-control study, Blood Pressure Determination, Treatment, Editor's Choice, RAMADAN, Cross-Sectional Studies, Cardiovascular System & Hematology, Case-Control Studies, Cardiovascular System & Cardiology, business, Hypertension, Blood pressure, Screening, Global, Treatment, Control
Abstract

Aims Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. Methods and results Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. Conclusion May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk.

Published
2019
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12. 2018 ESC/ESH Guidelines for the management of arterial hypertension : Grupa Robocza Europejskiego Towarzystwa Kardiologicznego (ESC) i Europejskiego Towarzystwa Nadciśnienia Tȩtniczego (ESH) do spraw postȩpowania w nadciśnieniu tȩtniczym

Author

Williams, Bryan, Mancia, Giuseppe, Spiering, Wilko, Rosei, Enrico Agabiti, Azizi, Michel, Burnier, Michel, Clement, Denis L., Coca, Antonio, De Simone, Giovanni, Dominiczak, Anna, Kahan, Thomas, Mahfoud, Felix, Redon, Josep, Ruilope, Luis, Zanchetti, Alberto, Kerins, Mary, Kjeldsen, Sverre E., Kreutz, Reinhold, Laurent, Stephane, Lip, Gregory Y.H., McManus, Richard, Narkiewicz, Krzysztof, Ruschitzka, Frank, Schmieder, Roland E., Shlyakhto, Evgeny, Tsioufis, Costas, Aboyans, Victor, Desormais, Ileana, Windecker, Stephan, Agewall, Stefan, Barbato, Emanuele, Bueno, Héctor, Collet, Jean Philippe, Coman, Ioan Mircea, Dean, Veronica, Delgado, Victoria, Fitzsimons, Donna, Gaemperli, Oliver, Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Knuuti, Juhani, Lancellotti, Patrizio, Leclercq, Christophe, McDonagh, Theresa A., Piepoli, Massimo Francesco, Ponikowski, Piotr, Richter, Dimitrios J., Roffi, Marco, Simpson, Iain A., Sousa-Uva, Miguel, Zamorano, Jose Luis, Lurbe, Empar, Bochud, Murielle, Jelakovic, Bojan, Januszewicz, Andrzej, Polonia, Jorge, Van De Borne, Philippe, Borghi, Claudio, Parati, Gianfranco, Manolis, Athanasios, Lovic, Dragan, Benkhedda, Salim, Zelveian, Parounak, Siostrzonek, Peter, Najafov, Ruslan, Pavlova, Olga, De Pauw, Michel, Dizdarevic-Hudic, Larisa, Raev, Dimitar, Karpettas, Nikos, Olsen, Michael Hecht, Shaker, Amin Fouad, Viigimaa, Margus, Baranova, Elena I., Metsärinne, Kaj, Halimi, Jean Michel, Pagava, Zurab, Thomopoulos, Costas, Bertomeu-Martinez, Vicente, Wittekoek, Janneke, Andersen, Karl, Shechter, Michael, Romanova, Tatiana, Bajraktari, Gani, Saade, Georges A., Sakalyte, Gintare, Noppe, Stéphanie, Trušinskis, Kārlis, Vavlukis, Marija, DeMarco, Daniela Cassar, Caraus, Alexandru, Schunkert, Heribert, Aksnes, Tonje Amb, Jankowski, Piotr, Linhart, Aleš, Vinereanu, Dragos, Foscoli, Marina, Dikic, Ana Djordjevic, Filipova, Slavomira, Fras, Zlatko, Burkard, Thilo, Carlberg, Bo, Sdiri, Wissem, Aydogdu, Sinan, Sirenko, Yuriy, Páll, Dénes, Brady, Adrian, Mercuro, Giuseppe, Weber, Thomas, Lazareva, Irina, De Backer, Tine, Sokolovic, Sekib, Chazova, Irina, Pörsti, Ilkka, Denolle, Thierry, Stergiou, George S., Segura, Julian, Miglinas, Marius, Krämer, Bernhard K., Gerdts, Eva, Tykarski, Andrzej, De Carvalho Rodrigues, Manuel, Widimsky, Jiri, Dorobantu, Maria, Brguljan, Jana, Pechère-Bertschi, Antoinette, Gottsäter, Anders, and Erdine, Serap

Subjects
Europe, Male, Antihypertensive Agents/therapeutic use, Practice Guideline, Hypertension/diagnosis, Cardiology, Journal Article, Disease Management, Humans, Female, Cardiology and Cardiovascular Medicine, Societies, Medical
Published
2019

13. Wytyczne ESC/ESH dotyczące postępowania w nadciśnieniu tętniczym (2018)

Author

Williams, Bryan, Mancia, Giuseppe, Spiering, Wilko, Agabiti Rosei, Enrico, Azizi, Michel, Burnier, Michel, Clement, Denis L, Coca, Antonio, de Simone, Giovanni, Dominiczak, Anna, Kahan, Thomas, Mahfoud, Felix, Redon, Josep, Ruilope, Luis, Zanchetti, Alberto, Kerins, Mary, Kjeldsen, Sverre E, Kreutz, Reinhold, Laurent, Stephane, Lip, Gregory Y H, McManus, Richard, Narkiewicz, Krzysztof, Ruschitzka, Frank, Schmieder, Roland E, Shlyakhto, Evgeny, Tsioufis, Costas, Aboyans, Victor, Desormais, Ileana, De Backer, Guy, Heagerty, Anthony M, Agewall, Stefan, Bochud, Murielle, Borghi, Claudio, Boutouyrie, Pierre, Brguljan, Jana, Bueno, Héctor, Caiani, Enrico G, Carlberg, Bo, Chapman, Neil, Cífková, Renata, Cleland, John G F, Collet, Jean-Philippe, Coman, Ioan Mircea, de Leeuw, Peter W, Delgado, Victoria, Dendale, Paul, Diener, Hans-Christoph, Dorobantu, Maria, Fagard, Robert, Farsang, Csaba, Ferrini, Marc, Graham, Ian M, Grassi, Guido, Haller, Hermann, Hobbs, F D Richard, Jelakovic, Bojan, Jennings, Catriona, Katus, Hugo A, Kroon, Abraham A, Leclercq, Christophe, Lovic, Dragan, Lurbe, Empar, Manolis, Athanasios J, McDonagh, Theresa A, Messerli, Franz, Muiesan, Maria Lorenza, Nixdorff, Uwe, Olsen, Michael Hecht, Parati, Gianfranco, Perk, Joep, Piepoli, Massimo Francesco, Polonia, Jorge, Ponikowski, Piotr, Richter, Dimitrios J, Rimoldi, Stefano F, Roffi, Marco, Sattar, Naveed, Seferovic, Petar M, Simpson, Iain A, Sousa-Uva, Miguel, Stanton, Alice V, van de Borne, Philippe, Vardas, Panos, Volpe, Massimo, Wassmann, Sven, Windecker, Stephan, Zamorano, Jose Luis, Barbato, Emanuele, Dean, Veronica, Fitzsimons, Donna, Gaemperli, Oliver, Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Knuuti, Juhani, Lancellotti, Patrizio, Rosei, Enrico Agabiti, Januszewics, Andrzej, Manolis, Athanasios, Benkhedda, Salim, Zelveian, Parounak, Siostrzonek, Peter, Najafov, Ruslan, Pavlova, Olga, De Pauw, Michel, Dizdarevic-Hudic, Larisa, Raev, Dimitar, Karpettas, Nikos, Linhart, Aleš, Shaker, Amin Fouad, Viigimaa, Margus, Metsärinne, Kaj, Vavlukis, Marija, Halimi, Jean-Michel, Pagava, Zurab, Schunkert, Heribert, Thomopoulos, Costas, Páll, Dénes, Andersen, Karl, Shechter, Michael, Mercuro, Giuseppe, Bajraktari, Gani, Romanova, Tatiana, Trušinskis, Kārlis, Saade, Georges A, Sakalyte, Gintare, Noppe, Stéphanie, DeMarco, Daniela Cassar, Caraus, Alexandru, Wittekoek, Janneke, Aksnes, Tonje Amb, Jankowski, Piotr, Vinereanu, Dragos, Baranova, Elena I, Foscoli, Marina, Dikic, Ana Djordjevic, Filipova, Slavomira, Fras, Zlatko, Bertomeu-Martínez, Vicente, Burkard, Thilo, Sdiri, Wissem, Aydogdu, Sinan, Sirenko, Yuriy, Brady, Adrian, Weber, Thomas, Lazareva, Irina, Backer, Tine De, Sokolovic, Sekib, Widimsky, Jiri, Pörsti, Ilkka, Denolle, Thierry, Krämer, Bernhard K, Stergiou, George S, Miglinas, Marius, Gerdts, Eva, Tykarski, Andrzej, de Carvalho Rodrigues, Manuel, Chazova, Irina, Segura, Julian, Gottsäter, Anders, Pechère-Bertschi, Antoinette, Erdine, Serap, Williams, Bryan, Mancia, Giuseppe, Spiering, Wilko, Rosei, Enrico Agabiti, Azizi, Michel, Burnier, Michel, Clement, Denis L., Coca, Antonio, De Simone, Giovanni, Dominiczak, Anna, Kahan, Thoma, Mahfoud, Felix, Redon, Josep, Ruilope, Lui, Zanchetti, Alberto, Kerins, Mary, Kjeldsen, Sverre E., Kreutz, Reinhold, Laurent, Stephane, Lip, Gregory Y. H., Mcmanus, Richard, Narkiewicz, Krzysztof, Ruschitzka, Frank, Schmieder, Roland E., Shlyakhto, Evgeny, Tsioufis, Costa, Aboyans, Victor, Desormais, Ileana, De Backer, Guy, Heagerty, Anthony M., Agewall, Stefan, Bochud, Murielle, Borghi, Claudio, Boutouyrie, Pierre, Brguljan, Jana, Bueno, Héctor, Caiani, Enrico G., Carlberg, Bo, Chapman, Neil, Cífková, Renata, Cleland, John G. F., Collet, Jean-Philippe, Coman, Ioan Mircea, De Leeuw, Peter W., Delgado, Victoria, Dendale, Paul, Diener, Hans-Christoph, Dorobantu, Maria, Fagard, Robert, Farsang, Csaba, Ferrini, Marc, Graham, Ian M., Grassi, Guido, Haller, Hermann, Hobbs, F. D. Richard, Jelakovic, Bojan, Jennings, Catriona, Katus, Hugo A., Kroon, Abraham A., Leclercq, Christophe, Lovic, Dragan, Lurbe, Empar, Manolis, Athanasios J., Mcdonagh, Theresa A., Messerli, Franz, Muiesan, Maria Lorenza, Nixdorff, Uwe, Olsen, Michael Hecht, Parati, Gianfranco, Perk, Joep, Piepoli, Massimo Francesco, Polonia, Jorge, Ponikowski, Piotr, Richter, Dimitrios J., Rimoldi, Stefano F., Roffi, Marco, Sattar, Naveed, Seferovic, Petar M., Simpson, Iain A., Sousa-Uva, Miguel, Stanton, Alice V., Van De Borne, Philippe, Vardas, Pano, Volpe, Massimo, Wassmann, Sven, Windecker, Stephan, Zamorano, Jose Luis, University College of London [London] (UCL), University College London Hospitals (UCLH), Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Université de Lausanne = University of Lausanne (UNIL), Institut de Mathématiques de Marseille (I2M), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU), BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Danderyds sjukhus = Danderyd University Hospital, Universitätsklinikum des Saarlandes, Universitat de València (UV), Hospital 12 de Octubre, Oslo University Hospital [Oslo], Clinical Pharmacology, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University of Liverpool, Aalborg University [Denmark] (AAU), Nuffield Department of Primary Care Health Sciences, University of Oxford, University of Oxford, Medical University of Gdańsk, University Heart Centre Freiburg - Bad Krozingen, Med Klinik IV, Univ.-Klinik Erlangen-Nürnberg, Almazov National Medical Research Centre (St. Petersburg), National and Kapodistrian University of Athens (NKUA), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de cardiologie [CHU Limoges], CHU Limoges, Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], Agabiti Rosei, Enrico, Clement, Denis L, de Simone, Giovanni, Kjeldsen, Sverre E, Lip, Gregory Y H, McManus, Richard, Schmieder, Roland E, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet [Stockholm], Chercheur indépendant, Department of Cardiology, Birmingham City Hospital, Department of Public Health, University of Gent, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Dipartimento di Elettronica, Informazione e Bioingegneria (DEIB), Politecnico di Milano [Milan] (POLIMI), 2nd Department of Internal Medicine, Hasselt University (UHasselt), Universität Duisburg-Essen [Essen], Australian Museum, Australian Museum [Sydney], Division of Nephrology and Hypertension, Department of Medicine, Hanover Medical School, Department of Earth Science, Durham University, School of Health and Caring Sciences, Linnaeus University, Department of Pathological Biochemistry, Royal Infirmary, Karolinska Institute, karolinska institute, 'Federico II' University of Naples Medical School, Hospital General Universitario 'Gregorio Marañón' [Madrid], Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), CHU de Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), St. Michael's Hospital, Heidelberg University Hospital [Heidelberg], Turku PET Centre, University of Turku, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-Research), Université de Liège, Wroclaw Medical University, Servicio de Pediatría, Consorcio Hospital General Universitario de Valencia, Institute of Social and Preventive Medicine, Lausanne university hospital, Department of Internal Medicine, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Aging and Clinical Nephrology, Food Science and Technology, Université Francois Rabelais [Tours], Medizinische Klinik II, Universität zu Lübeck [Lübeck], Warsaw University of Technology [Warsaw], Cardiology, University and Emergency Hospital, IRCELYON-Catalytic and Atmospheric Reactivity for the Environment (CARE), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Sheffield [Sheffield], Faculty of metals engineering and industrial computer science, Centre of Cardiology, North Estonia Medical Centre, Medical School, University of Tampere [Finland], Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], IRCCS Istituto Auxologico Italiano, University of Zurich, Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hasselt University, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP], Università di Bologna [Bologna] (UNIBO)-Aging and Clinical Nephrology, Universität zu Lübeck [Lübeck] - University of Lübeck [Lübeck], IRCELYON-Caractérisation et remédiation des polluants dans l'air et l'eau (CARE), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Service de cardiologie et maladies vasculaires [CHU de Rennes], Diener, Hans Christoph (Beitragende*r), Williams, B, Mancia, G, Spiering, W, Agabiti Rosei, E, Azizi, M, Burnier, M, Clement, D, Coca, A, de Simone, G, Dominiczak, A, Kahan, T, Mahfoud, F, Redon, J, Ruilope, L, Zanchetti, A, Kerins, M, Kjeldsen, S, Kreutz, R, Laurent, S, Lip, G, Mcmanus, R, Narkiewicz, K, Ruschitzka, F, Schmieder, R, Shlyakhto, E, Tsioufis, C, Aboyans, V, Desormais, I, and Grassi, G

Subjects
Male, Lifestyle intervention, [SDV]Life Sciences [q-bio], Medizin, Secondary hypertension, 030204 cardiovascular system & hematology, Guideline, Hypertension-mediated organ damage, Blood pressure treatment thresholds and targets, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Disease management (health), 610 Medicine & health, Lifestyle interventions, Societies, Medical, ComputingMilieux_MISCELLANEOUS, Disease Management, Blood pressure, Blood pressure measurement, Combination therapy, Device therapy, Drug therapy, Guidelines, Hypertension, Cardiology and Cardiovascular Medicine, Europe, Arterial hypertension, blood pressure control, guidelines, 10209 Clinic for Cardiology, Female, medicine.medical_specialty, Blood pressure treatment thresholds and target, MEDLINE, Cardiology, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, Pharmacotherapy, Blood pressure treatmentthresholds and targets, Journal Article, Humans, Hypertension diagnosis, Intensive care medicine, Antihypertensive Agents, business.industry, medicine.disease, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

International audience; : Document reviewers: Guy De Backer (ESC Review Co-ordinator) (Belgium), Anthony M. Heagerty (ESH Review Co-ordinator) (UK), Stefan Agewall (Norway), Murielle Bochud (Switzerland), Claudio Borghi (Italy), Pierre Boutouyrie (France), Jana Brguljan (Slovenia), Héctor Bueno (Spain), Enrico G. Caiani (Italy), Bo Carlberg (Sweden), Neil Chapman (UK), Renata Cifkova (Czech Republic), John G. F. Cleland (UK), Jean-Philippe Collet (France), Ioan Mircea Coman (Romania), Peter W. de Leeuw (The Netherlands), Victoria Delgado (The Netherlands), Paul Dendale (Belgium), Hans-Christoph Diener (Germany), Maria Dorobantu (Romania), Robert Fagard (Belgium), Csaba Farsang (Hungary), Marc Ferrini (France), Ian M. Graham (Ireland), Guido Grassi (Italy), Hermann Haller (Germany), F. D. Richard Hobbs (UK), Bojan Jelakovic (Croatia), Catriona Jennings (UK), Hugo A. Katus (Germany), Abraham A. Kroon (The Netherlands), Christophe Leclercq (France), Dragan Lovic (Serbia), Empar Lurbe (Spain), Athanasios J. Manolis (Greece), Theresa A. McDonagh (UK), Franz Messerli (Switzerland), Maria Lorenza Muiesan (Italy), Uwe Nixdorff (Germany), Michael Hecht Olsen (Denmark), Gianfranco Parati (Italy), Joep Perk (Sweden), Massimo Francesco Piepoli (Italy), Jorge Polonia (Portugal), Piotr Ponikowski (Poland), Dimitrios J. Richter (Greece), Stefano F. Rimoldi (Switzerland), Marco Roffi (Switzerland), Naveed Sattar (UK), Petar M. Seferovic (Serbia), Iain A. Simpson (UK), Miguel Sousa-Uva (Portugal), Alice V. Stanton (Ireland), Philippe van de Borne (Belgium), Panos Vardas (Greece), Massimo Volpe (Italy), Sven Wassmann (Germany), Stephan Windecker (Switzerland), Jose Luis Zamorano (Spain).The disclosure forms of all experts involved in the development of these Guidelines are available on the ESC website www.escardio.org/guidelines.

Published
2018
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14. Patients with rheumatoid arthritis facing sick leave or work disability meet varying regulations: a study among rheumatologists and patients from 44 European countries

Author

Putrik, Polina, primary, Ramiro, Sofia, additional, Guillemin, Francis, additional, Péntek, Márta, additional, Sivera, Francisca, additional, Sokka, Tuulikki, additional, de Wit, Maarten, additional, Woolf, Anthony D, additional, Zink, Angela, additional, Andersone, Daina, additional, Berghea, Florian, additional, Butrimiene, Irena, additional, Brouwer, Sandra, additional, Cassar, Karen, additional, Charalambous, Paraskevi, additional, Caporali, Roberto, additional, Deseatnicova, Elena, additional, Damjanov, Nemanja S, additional, Finckh, Axel, additional, FitzGerald, Oliver, additional, Gröndal, Gerður, additional, Gobejishjvili, Nino, additional, Gluszko, Piotr, additional, Hirsch, Marco, additional, Jovanovic, Igor, additional, Vencovský, Jiří, additional, Janssens, Xavier, additional, Keszei, Andras P, additional, Kovarova, Maria, additional, Kull, Mart, additional, Cunha Miranda, Luís, additional, Mayer, Miroslav, additional, Misevska - Percinkova, Snezana, additional, Inanc, Nevsun, additional, Nadashkevich, Oleg, additional, Petersson, Ingemar F, additional, Puolakka, Kari, additional, Rojkovich, Bernadette, additional, Radner, Helga, additional, Szabados, Fruzsina, additional, Slobodin, Gleb, additional, Shirinsky, Ivan, additional, Soroka, Nikolay, additional, Sidiropoulos, Prodromos, additional, Shumnalieva, Russka, additional, Sokolovic, Sekib, additional, Shukurova, Surayo, additional, Tafaj, Argjend, additional, Tomšič, Matija, additional, Uhlig, Till, additional, Verstappen, Suzanne M M, additional, and Boonen, Annelies, additional

Published
2019
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15. 2018 ESC/ESH Guidelines for the management of arterial hypertension: Grupa Robocza Europejskiego Towarzystwa Kardiologicznego (ESC) i Europejskiego Towarzystwa Nadciśnienia Tȩtniczego (ESH) do spraw postȩpowania w nadciśnieniu tȩtniczym

Author

Interne Geneeskunde Vasculaire, MS Interne Geneeskunde, Circulatory Health, Williams, Bryan, Mancia, Giuseppe, Spiering, Wilko, Rosei, Enrico Agabiti, Azizi, Michel, Burnier, Michel, Clement, Denis L., Coca, Antonio, De Simone, Giovanni, Dominiczak, Anna, Kahan, Thomas, Mahfoud, Felix, Redon, Josep, Ruilope, Luis, Zanchetti, Alberto, Kerins, Mary, Kjeldsen, Sverre E., Kreutz, Reinhold, Laurent, Stephane, Lip, Gregory Y.H., McManus, Richard, Narkiewicz, Krzysztof, Ruschitzka, Frank, Schmieder, Roland E., Shlyakhto, Evgeny, Tsioufis, Costas, Aboyans, Victor, Desormais, Ileana, Windecker, Stephan, Agewall, Stefan, Barbato, Emanuele, Bueno, Héctor, Collet, Jean Philippe, Coman, Ioan Mircea, Dean, Veronica, Delgado, Victoria, Fitzsimons, Donna, Gaemperli, Oliver, Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Knuuti, Juhani, Lancellotti, Patrizio, Leclercq, Christophe, McDonagh, Theresa A., Piepoli, Massimo Francesco, Ponikowski, Piotr, Richter, Dimitrios J., Roffi, Marco, Simpson, Iain A., Sousa-Uva, Miguel, Zamorano, Jose Luis, Lurbe, Empar, Bochud, Murielle, Jelakovic, Bojan, Januszewicz, Andrzej, Polonia, Jorge, Van De Borne, Philippe, Borghi, Claudio, Parati, Gianfranco, Manolis, Athanasios, Lovic, Dragan, Benkhedda, Salim, Zelveian, Parounak, Siostrzonek, Peter, Najafov, Ruslan, Pavlova, Olga, De Pauw, Michel, Dizdarevic-Hudic, Larisa, Raev, Dimitar, Karpettas, Nikos, Olsen, Michael Hecht, Shaker, Amin Fouad, Viigimaa, Margus, Baranova, Elena I., Metsärinne, Kaj, Halimi, Jean Michel, Pagava, Zurab, Thomopoulos, Costas, Bertomeu-Martinez, Vicente, Wittekoek, Janneke, Andersen, Karl, Shechter, Michael, Romanova, Tatiana, Bajraktari, Gani, Saade, Georges A., Sakalyte, Gintare, Noppe, Stéphanie, Trušinskis, Kārlis, Vavlukis, Marija, DeMarco, Daniela Cassar, Caraus, Alexandru, Schunkert, Heribert, Aksnes, Tonje Amb, Jankowski, Piotr, Linhart, Aleš, Vinereanu, Dragos, Foscoli, Marina, Dikic, Ana Djordjevic, Filipova, Slavomira, Fras, Zlatko, Burkard, Thilo, Carlberg, Bo, Sdiri, Wissem, Aydogdu, Sinan, Sirenko, Yuriy, Páll, Dénes, Brady, Adrian, Mercuro, Giuseppe, Weber, Thomas, Lazareva, Irina, De Backer, Tine, Sokolovic, Sekib, Chazova, Irina, Pörsti, Ilkka, Denolle, Thierry, Stergiou, George S., Segura, Julian, Miglinas, Marius, Krämer, Bernhard K., Gerdts, Eva, Tykarski, Andrzej, De Carvalho Rodrigues, Manuel, Widimsky, Jiri, Dorobantu, Maria, Brguljan, Jana, Pechère-Bertschi, Antoinette, Gottsäter, Anders, Erdine, Serap, Interne Geneeskunde Vasculaire, MS Interne Geneeskunde, Circulatory Health, Williams, Bryan, Mancia, Giuseppe, Spiering, Wilko, Rosei, Enrico Agabiti, Azizi, Michel, Burnier, Michel, Clement, Denis L., Coca, Antonio, De Simone, Giovanni, Dominiczak, Anna, Kahan, Thomas, Mahfoud, Felix, Redon, Josep, Ruilope, Luis, Zanchetti, Alberto, Kerins, Mary, Kjeldsen, Sverre E., Kreutz, Reinhold, Laurent, Stephane, Lip, Gregory Y.H., McManus, Richard, Narkiewicz, Krzysztof, Ruschitzka, Frank, Schmieder, Roland E., Shlyakhto, Evgeny, Tsioufis, Costas, Aboyans, Victor, Desormais, Ileana, Windecker, Stephan, Agewall, Stefan, Barbato, Emanuele, Bueno, Héctor, Collet, Jean Philippe, Coman, Ioan Mircea, Dean, Veronica, Delgado, Victoria, Fitzsimons, Donna, Gaemperli, Oliver, Hindricks, Gerhard, Iung, Bernard, Jüni, Peter, Katus, Hugo A., Knuuti, Juhani, Lancellotti, Patrizio, Leclercq, Christophe, McDonagh, Theresa A., Piepoli, Massimo Francesco, Ponikowski, Piotr, Richter, Dimitrios J., Roffi, Marco, Simpson, Iain A., Sousa-Uva, Miguel, Zamorano, Jose Luis, Lurbe, Empar, Bochud, Murielle, Jelakovic, Bojan, Januszewicz, Andrzej, Polonia, Jorge, Van De Borne, Philippe, Borghi, Claudio, Parati, Gianfranco, Manolis, Athanasios, Lovic, Dragan, Benkhedda, Salim, Zelveian, Parounak, Siostrzonek, Peter, Najafov, Ruslan, Pavlova, Olga, De Pauw, Michel, Dizdarevic-Hudic, Larisa, Raev, Dimitar, Karpettas, Nikos, Olsen, Michael Hecht, Shaker, Amin Fouad, Viigimaa, Margus, Baranova, Elena I., Metsärinne, Kaj, Halimi, Jean Michel, Pagava, Zurab, Thomopoulos, Costas, Bertomeu-Martinez, Vicente, Wittekoek, Janneke, Andersen, Karl, Shechter, Michael, Romanova, Tatiana, Bajraktari, Gani, Saade, Georges A., Sakalyte, Gintare, Noppe, Stéphanie, Trušinskis, Kārlis, Vavlukis, Marija, DeMarco, Daniela Cassar, Caraus, Alexandru, Schunkert, Heribert, Aksnes, Tonje Amb, Jankowski, Piotr, Linhart, Aleš, Vinereanu, Dragos, Foscoli, Marina, Dikic, Ana Djordjevic, Filipova, Slavomira, Fras, Zlatko, Burkard, Thilo, Carlberg, Bo, Sdiri, Wissem, Aydogdu, Sinan, Sirenko, Yuriy, Páll, Dénes, Brady, Adrian, Mercuro, Giuseppe, Weber, Thomas, Lazareva, Irina, De Backer, Tine, Sokolovic, Sekib, Chazova, Irina, Pörsti, Ilkka, Denolle, Thierry, Stergiou, George S., Segura, Julian, Miglinas, Marius, Krämer, Bernhard K., Gerdts, Eva, Tykarski, Andrzej, De Carvalho Rodrigues, Manuel, Widimsky, Jiri, Dorobantu, Maria, Brguljan, Jana, Pechère-Bertschi, Antoinette, Gottsäter, Anders, and Erdine, Serap

Published
2019

18. The Second Mediterranean Seminar on Science Writing, Editing and Publishing (SWEP - 2018), Sarajevo, December 8th, 2018

Author

Masic, Izet, primary, Jakovljevic, Miro, additional, Sinanovic, Osman, additional, Gajovic, Srecko, additional, Spiroski, Mirko, additional, Jusufovic, Rasim, additional, Sokolovic, Sekib, additional, Prnjavorac, Besim, additional, Zerem, Enver, additional, Djulbegovic, Benjamin, additional, Porovic, Selma, additional, Jankovic, Slobodan, additional, Hadzikadic, Mirsad, additional, Zunic, Lejla, additional, Begic, Edin, additional, Nislic, Edin, additional, Begic, Nedim, additional, Becirovic, Emir, additional, Cerovac, Anis, additional, Skrijelj, Venesa, additional, and Nuhanovic, Jasmina, additional

Published
2018
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21. Koopman FA, Miljko S, Grazio S i sur. Pilot study of stimulation of the cholinergic anti-inflammatory pathway with an implantabale vagus nerve stimulation device in patients with rheumatoid arthrtis

Author

Koopman, Frieda A., Miljko, Sanda, Grazio, Simeon, Sokolovic, Sekib, Tracey, Kevin, Levine, Yaakov, and Zitnik, Ralph

Subjects
nema dostupnih podataka
Abstract

Background/Purpose. The inflammatory reflex regulates innate and adaptive immunity (Andersson O, Tracey K, Annu. Rev. Immunol. 2012 ; 30:313). Activation of its efferent arm (the Cholinergic Anti-inflammatory Pathway (CAP)), by electrical vagus nerve stimulation (VNS) reduces systemic inflammation and ameliorates disease in many acute and chronic animal models. We determined whether VNS could similarly improve clinical manifestations of rheumatoid arthritis (RA). Methods. This is an open label study of patients with active RA (>/= 4 tender and 4 swollen joints (28 joint scoring), and CRP of at least 7 mg/L) despite stable methotrexate dose for 3 months. Patients failing TNF antagonists (only for safety or tolerability reasons) could also be enrolled after washout. After a pre-implantation baseline visit, patients were surgically implanted with a Cyberonics VNS system. The device delivered the first VNS during its standard intraoperative diagnostic check sequence. Two weeks following implantation patients returned for initial in-clinic VNS. One week after the first clinic visit (day 7), patients began self-delivery of 60 second, once daily home stimulations, escalated in output current intensity as tolerated, through day 28. At day 28 patients without a EULAR good or moderate response were increased to four times daily VNS. Primary endpoint results at day 42 are reported. Results. 8 patients (4 female, 7/8 RF+, 6/8 ACPA+, mean age 56 [range 39–70], mean disease duration 8 yrs [range 0.5–13]) were enrolled and implanted. Implantation and stimulation were generally well tolerated. Moderate postoperative hoarseness occurred in one patient. Pre implantation baseline values (mean, SD) were: DAS28-CRP: 6.06 (0.87), CRP: 17.5 mg/L (9.9), HAQ-DI: 1.63 (0.90). Changes at day 42 visit from pre-implantation values were: DAS28-CRP: -2.28 (1.65), CRP: -3.46 (17.95) mg/L, HAQ-DI: -0.44 (0.48).Similar levels of improvement were seen across all ACR core set assessments. ACR 20/50/70 response rates from pre-implantation baseline to day 42 were 75% (6/8), 50% (4/8), and 25% (2/8), respectively. Conclusion. In this pilot study VNS was generally well tolerated and improved signs and symptoms of RA. This is the first demonstration in humans that stimulation of the CAP can favorably impact clinical manifestations of systemic inflammation. If efficacy and safety are confirmed in larger controlled studies, implantable medical devices may offer a feasible alternative approach to the treatment of RA and other chronic inflammatory diseases.

Published
2012

22. Echocardiographic Assessment of Ischaemic Mitral Regurgitation, Mechanism, Severity, Impact on Treatment Strategy and Long Term Outcome

Author

Naser, Nabil, primary, Dzubur, Alen, additional, Kusljugic, Zumreta, additional, Kovacevic, Katarina, additional, Kulic, Mehmed, additional, Sokolovic, Sekib, additional, Terzic, Ibrahim, additional, HaxihibeqiriKarabdic, Ilirijana, additional, Hondo, Zorica, additional, Brdzanovic, Snjezana, additional, and Miseljic, and, additional

Published
2016
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23. The First Mediterranean Seminar on Science Writing, Editing and Publishing, Sarajevo, December 2-3, 2016

Author

Masic, Izet, primary, Donev, Doncho, additional, Sinanovic, Osman, additional, Jakovljevic, Miro, additional, Zerem, Enver, additional, Milosevic, Dejan, additional, Gajovic, Srecko, additional, Gasparyan, Armen, additional, Sokolovic, Sekib, additional, Salkic, Nermin, additional, Uzunovic, Selma, additional, Dobric, Silva, additional, Kurti, Floreta, additional, Begic, Edin, additional, and Kurtcehajic, Admir, additional

Published
2016
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33. Management of patients with hypertension and chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. On behalf of the European Society of Hypertension Working Group on Hypertension and the Kidney.

Author

Halimi JM, Sarafidis P, Azizi M, Bilo G, Burkard T, Bursztyn M, Camafort M, Chapman N, Cottone S, de Backer T, Deinum J, Delmotte P, Dorobantu M, Doumas M, Dusing R, Duly-Bouhanick B, Fauvel JP, Fesler P, Gaciong Z, Gkaliagkousi E, Gordin D, Grassi G, Grassos C, Guerrot D, Huart J, Izzo R, Jaén Águila F, Járai Z, Kahan T, Kantola I, Kociánová E, Limbourg F, Lopez-Sublet M, Mallamaci F, Manolis A, Marketou M, Mayer G, Mazza A, MacIntyre I, Mourad JJ, Muiesan ML, Nasr E, Nilsson P, Oliveras A, Ormezzano O, Paixão-Dias V, Papadakis I, Papadopoulos D, Perl S, Polónia J, Pontremoli R, Pucci G, Robles NR, Rubin S, Ruilope LM, Rump LC, Saeed S, Sanidas E, Sarzani R, Schmieder R, Silhol F, Sokolovic S, Solbu M, Soucek M, Stergiou G, Sudano I, Tabbalat R, Tengiz I, Triantafyllidi H, Tsioufis K, Václavík J, van der Giet M, der Niepen PV, Veglio F, Venzin R, Viigimaa M, Weber T, Widimsky J, Wuerzner G, Zelveian P, Zebekakis P, Lueders S, Persu A, Kreutz R, and Vogt L

Subjects
Humans, Europe, Antihypertensive Agents therapeutic use, Male, Surveys and Questionnaires, Female, Middle Aged, Calcium Channel Blockers therapeutic use, Societies, Medical, Angiotensin Receptor Antagonists therapeutic use, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic drug therapy, Hypertension drug therapy
Abstract

Objective Real-life management of patients with hypertension and chronic kidney disease (CKD) among European Society of Hypertension Excellence Centres (ESH-ECs) is unclear : we aimed to investigate it. Methods A survey was conducted in 2023. The questionnaire contained 64 questions asking ESH-ECs representatives to estimate how patients with CKD are managed. Results Overall, 88 ESH-ECS representatives from 27 countries participated. According to the responders, renin-angiotensin system (RAS) blockers, calcium-channel blockers and thiazides were often added when these medications were lacking in CKD patients, but physicians were more prone to initiate RAS blockers (90% [interquartile range: 70-95%]) than MRA (20% [10-30%]), SGLT2i (30% [20-50%]) or (GLP1-RA (10% [5-15%]). Despite treatment optimisation, 30% of responders indicated that hypertension remained uncontrolled (30% (15-40%) vs 18% [10%-25%]) in CKD and CKD patients, respectively). Hyperkalemia was the most frequent barrier to initiate RAS blockers, and dosage reduction was considered in 45% of responders when kalaemia was 5.5-5.9 mmol/L. Conclusions RAS blockers are initiated in most ESH-ECS in CKD patients, but MRA and SGLT2i initiations are less frequent. Hyperkalemia was the main barrier for initiation or adequate dosing of RAS blockade, and RAS blockers' dosage reduction was the usual management.

Published
2024
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34. Screening and management of hypertensive patients with chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. A pilot survey based on questionnaire.

Author

Halimi JM, Sarafidis P, Azizi M, Bilo G, Burkard T, Bursztyn M, Camafort M, Chapman N, Cottone S, de Backer T, Deinum J, Delmotte P, Dorobantu M, Doumas M, Dusing R, Duly-Bouhanick B, Fauvel JP, Fesler P, Gaciong Z, Gkaliagkousi E, Gordin D, Grassi G, Grassos C, Guerrot D, Huart J, Izzo R, Águila FJ, Járai Z, Kahan T, Kantola I, Kociánová E, Limbourg FP, Lopez-Sublet M, Mallamaci F, Manolis A, Marketou M, Mayer G, Mazza A, MacIntyre IM, Mourad JJ, Muiesan ML, Nasr E, Nilsson P, Oliveras A, Ormezzano O, Paixão-Dias V, Papadakis I, Papadopoulos D, Perl S, Polónia J, Pontremoli R, Pucci G, Robles NR, Rubin S, Ruilope LM, Rump LC, Saeed S, Sanidas E, Sarzani R, Schmieder R, Silhol F, Sokolovic S, Solbu M, Soucek M, Stergiou G, Sudano I, Tabbalat R, Tengiz I, Triantafyllidi H, Tsioufis K, Václavík J, van der Giet M, Van der Niepen P, Veglio F, Venzin RM, Viigimaa M, Weber T, Widimsky J, Wuerzner G, Zelveian P, Zebekakis P, Lueders S, Persu A, Kreutz R, and Vogt L

Subjects
Humans, Surveys and Questionnaires, Male, Female, Pilot Projects, Referral and Consultation, Antihypertensive Agents therapeutic use, Middle Aged, Mass Screening methods, Europe, Aged, Glomerular Filtration Rate, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic physiopathology, Hypertension drug therapy, Hypertension complications
Abstract

Objective: Real-life management of hypertensive patients with chronic kidney disease (CKD) is unclear., Methods: A survey was conducted in 2023 by the European Society of Hypertension (ESH) to assess management of CKD patients referred to ESH-Hypertension Excellence Centres (ESH-ECs) at first referral visit. The questionnaire contained 64 questions with which ESH-ECs representatives were asked to estimate preexisting CKD management quality., Results: Overall, 88 ESH-ECs from 27 countries participated (fully completed surveys: 66/88 [75.0%]). ESH-ECs reported that 28% (median, interquartile range: 15-50%) had preexisting CKD, with 10% of them (5-30%) previously referred to a nephrologist, while 30% (15-40%) had resistant hypertension. The reported rate of previous recent (<6 months) estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (UACR) testing were 80% (50-95%) and 30% (15-50%), respectively. The reported use of renin-angiotensin system blockers was 80% (70-90%). When a nephrologist was part of the ESH-EC teams the reported rates SGLT2 inhibitors (27.5% [20-40%] vs. 15% [10-25], P  = 0.003), GLP1-RA (10% [10-20%] vs. 5% [5-10%], P  = 0.003) and mineralocorticoid receptor antagonists (20% [10-30%] vs. 15% [10-20%], P  = 0.05) use were greater as compared to ESH-ECs without nephrologist participation. The rate of reported resistant hypertension, recent eGFR and UACR results and management of CKD patients prior to referral varied widely across countries., Conclusions: Our estimation indicates deficits regarding CKD screening, use of nephroprotective drugs and referral to nephrologists before referral to ESH-ECs but results varied widely across countries. This information can be used to build specific programs to improve care in hypertensives with CKD., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)

Published
2024
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35. Minimally Invasive Aortic Valve Replacement: Case Series Study.

Author

Karic A, Avdagic H, Kalinic N, Busevac E, Krajnovic A, and Sokolovic S

Subjects
Humans, Male, Aged, Female, Aortic Valve surgery, Treatment Outcome, Aged, 80 and over, Postoperative Complications epidemiology, Middle Aged, Aortic Valve Stenosis surgery, Minimally Invasive Surgical Procedures methods, Length of Stay statistics & numerical data, Heart Valve Prosthesis Implantation methods, Heart Valve Prosthesis Implantation economics, Sternotomy methods
Abstract

Background: Degenerative aortic stenosis is a prevalent and severe condition necessitating aortic valve replacement (AVR) when the valve area critically narrows to 0.7 cm² or when symptoms are manifested. Traditional AVR via median sternotomy, poses considerable risks for patients with comorbidities or advanced age., Objective: This study evaluates the efficacy and safety of mini sternotomy aortic valve replacement (MSAVR), a minimally invasive technique designed to reduce surgical trauma, improve postoperative recovery, and lower healthcare costs., Methods: A reversed L-type upper partial sternotomy (RLUPS) approach was performed in five patients focusing on standardized surgical procedures, and rigorous postoperative care. Key findings indicate that MSAVR markedly reduces postoperative complications, ICU stay, and overall hospital stay compared to traditional sternotomy., Results: The median postoperative length of stay was seven days for MSAVR versus 12 days for traditional sternotomy, with ICU stays of 52 hours and 119 hours, respectively. Our study also highlights the cost-effectiveness of MSAVR, with decreased hospital costs per patient due to reduced ICU resource utilization and shorter hospital stays. These findings suggest that MSAVR is a valuable and advantageous alternative to traditional sternotomy, offering substantial benefits in terms of patient outcomes and healthcare efficiency., Conclusion: Our work underscores the potential of minimally invasive techniques in improving the management of severe degenerative aortic stenosis, marking a significant advancement in the field of cardiac surgery., Competing Interests: None to declare., (© 2024 Alen Karic, Harun Avdagic, Novica Kalinic, Ervin Busevac, Alma Krajnovic, Sekib Sokolovic.)

Published
2024
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36. Impact of Different Types of Statins on Clinical Outcomes in Patients Hospitalized for Ischemic Heart Failure.

Author

Zvizdić F, Godinjak A, Durak-Nalbantic A, Rama A, Iglica A, Vucijak-Grgurevic M, and Sokolovic S

Subjects
Aged, Comorbidity, Disease Progression, Female, Heart Failure mortality, Heart Failure physiopathology, Hospitalization, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors classification, Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology, Male, Middle Aged, Prognosis, Treatment Outcome, Ventricular Function, Left physiology, Heart Failure drug therapy, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Ventricular Function, Left drug effects
Abstract

Introduction: The effect of statins on risk of heart failure (HF) hospitalization and lethal outcome remains dubious., Aim: To investigate whether statin therapy improves clinical outcomes in patients hospitalized for ischemic heart failure (HF), to compare the efficacy of lipophilic and hydrophilic statins and to investigate which statin subtype provides better survival and other outcome benefits., Material and Methods: Total amount of 155 patients in the study were admitted to the Clinic for Cardiology, Rheumatology and Vascular diseases in Clinical Center University of Sarajevo in the period from January 2014- December 2017. Inclusion criteria was HF caused by ischemic coronary artery disease upon admission. For each patient the following data were obtained: gender, age, comorbidities and medications on discharge. New York Heart Association (NYHA) class for heart failure was determined by physician evaluation and left ventricle ejection fraction (LVEF) was determined by echocardiography. The patients were followed for a period of two years. Outcome points were: rehospitalization, in-hospital death, mortality after 6 months, 1 year and 2 years. All-cause mortality included cardiovascular events or worsening heart failure., Results: Overall, 58.9% of HF patients received statin therapy, with 33.9% patients receiving atorvastatin and 25.0% rosuvastatin therapy. The most frequent rehospitalization was in patients without statin therapy (66.7%), followed by patients on rosuvastatin (64.1%), and atorvastatin (13.2%), with statistically significant difference p = 0.001 between the groups. Mortality after 6 months, 1 year and 2 years was the most frequent in patients without statin therapy with a statistically significant difference (p = 0.001). Progression of HF accounted for 31.7% of mortality in patients without statin therapy, 12.8% in patients on rosuvastatin therapy and 3.8% in patients on atorvastatin therapy (p = 0.004)., Conclusion: Lipophilic statin therapy is associated with substantially better long-term outcomes in patients with HF.

Published
2018
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37. Serum level of tumor marker carbohydrate antigen-CA125 in heart failure.

Author

Durak-Nalbantic A, Resic N, Kulic M, Pecar E, Zvizdic F, Dzubur A, Dilic M, Gojak R, Sokolovic S, Hodzic E, and Brdjanovic S

Subjects
Aged, Aged, 80 and over, Atrial Fibrillation blood, Atrial Fibrillation complications, Case-Control Studies, Echocardiography, Female, Heart Failure complications, Heart Failure diagnostic imaging, Humans, Male, Middle Aged, Natriuretic Peptide, Brain blood, Pericardial Effusion blood, Pericardial Effusion complications, Pleural Effusion blood, Pleural Effusion complications, CA-125 Antigen blood, Heart Failure blood, Membrane Proteins blood
Abstract

Objective: To assess serum levels of tumor marker carbohydrate antigen 125 (CA125) in patients with heart failure (HF) and to investigate possible correlation with echocardiographic parameters and level of brain natriuretic peptide (BNP)., Patients and Methods: We included 76 patients with different cardiac symptoms hospitalized at Clinic for heart disease and rheumatism. Control group (n = 26) was consisted of patients without signs and symptoms of HF, normal left ventricle ejection fraction (LVEF) and normal BNP level. Patients with diagnosis of HF (n = 50) were subdivided into 2 group depending on signs and symptoms of fluid overload: compensated (compHF, n = 10) and decompensated group (decompHF, n = 40). Serum CA125 and BNP were measured on admission and all patient underwent ECG recording and trans thoracic echocardiographic examination., Results: The median CA125 level in HF group was significantly higher compared to control group (71.05 [30.70-141.47]U/ml vs 10.75 [8.05- 14.32] U/ml, p < 0.0005). Higher CA125 levels were found in decompHF group compared to compHF group (94.90 [49.75-196.75]U/ml vs 11.90 [10.25-15.80]U/ml, p < 0.0005). In decompHF group 13 of patients had pleural and/or pericardial effusion- their CA125 levels were significantly higher compared to patients without serosal effusion (n = 27) (205.10 [106.50-383.90]U/ml vs. 71.50 [47.30-109.55] U/ml, p < 0.002). We found significant difference in CA125 levels between patients with atrial fibrillation and sinus rhythm (98.40 [48.20-242.70] U/ml vs. 47.30 [12.95-99.05] U/ml, p = 0.015). There was no significant difference in CA125 levels in group with enlarged left atrium compared to normal sized atrium (p = 0.282), as well as in group with moderate/severe mitral regurgitation compared to group with no/mild mitral regurgitation (p = 0.99). Finally, levels of serum CA125 positively correlated with serum level of BNP (r = 0.293, p = 0.039), but not with LVEF (p = 0.369) and left atrium diameter (p = 0.636)., Conclusion: Serum CA125 is elevated in decompensated HF patients: more pronounced elevation was found in patients with pleural and/or pericard effusion compared to patients with no serosal effusion. CA125 level correlated with BNP, but not with left atrium diameter nor with LVEF. Tumor marker CA125 could be used as a marker of systemic congestion and volume overload in decompensated HF. We hypothesized that high CA125 level indicates that measured high BNP is actually wet BNP.

Published
2013
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38. The role of echocardiography in diagnosis and follow up of patients with takotsubo cardiomyopathy or acute ballooning syndrome.

Author

Naser N, Buksa M, Kusljugic Z, Terzic I, Sokolovic S, and Hodzic E

Subjects
Acute Coronary Syndrome complications, Adult, Aged, Female, Humans, Male, Middle Aged, Takotsubo Cardiomyopathy complications, Echocardiography, Echocardiography, Transesophageal, Takotsubo Cardiomyopathy diagnostic imaging
Abstract

Background: The transient left ventricular apical ballooning syndrome, also known as takotsubo cardiomyopathy was first described in Japan approximately 20 years ago (Satoh and coworkers, 1991). It was later described elsewhere as well and is being increasingly recognized. Takotsubo Cardiomyopathy characterized by transient apical and midventricular LV dysfunction in the absence of significant coronary artery disease that is triggered by emotional or physical stress. Its name refers to a contraption used for catching octopuses and suggests the aspect assumed by the ventricle during the systole due to the typical regional wall motion abnormalities that occur after onset. Takotsubo cardiomiopathy occurring mainly in post-menopausal women, echocardiography in the Takotsubo cardiomyopathy reveals during its acute phase a ballooning resembling the octopus trap configuration--the apex and lateral ventricular segments are hypokinetic while the base is hyperkinetic--along with reduced ejection fraction. Ventricular function will usually recover within a few days/weeks., Objective and Purpose: The objective of this study is to determine the role of echocardiography in detecting and establishing the diagnosis of Takotsubo cardiomiopathy in patients with suspect acute coronary syndrome and during the follow up period., Patients and Methods: The study covered 12 adult patients the majority are women (92%) who were subjected to echocardiography evaluation as part of the clinical cardiological examination due to suspect acute coronary syndrome or Takotsubo Stress Cardiomyopathy. The patients were examined on an ultrasound machine Philips iE 33 x Matrix, ATL HDI and GE Vived 7 equipped with all cardiologic probes for adults and multi-plan TEE probes. We evaluated clinical characteristics, LV systolic function, biomarkers, and prognosis in all patients., Results: Among all the patients referred for Echocardiographic evaluation for left ventricle motion abnormalities with suspect acute coronary syndrome, the echo exam revealed 12 patients with acute apical ballooning which involving the left ventricular apex and med-ventricle. The triggering factors were physical stress in 4 patients (33%) and emotional stress in 8 patients (67%). The initial symptom was chest pain (n = 8, 67%) rather than dyspnea (n = 4, 33%). An initial electrocardiogram (EKG) presented ST-elevation (n = 10, 83%) and T-wave inversion (n = 2, 17%), other data are shown on Table 2. Among the all patients 8 of them (66%) had normal EF by the 1st follow up (47 +/- 51 days), and the rest 4 patients (34%) had normal EF by 68 +/- 96 days., Conclusion: Widespread uses of echocardiography has contributed to more frequent recognition of Takotsubo stress cardiomyopathy and highlight the central role of this noninvasive method from an echocardiographers' perspective.

Published
2011
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39. Stress echocardiography in differentiation of fixed vs. low flow-low gradient and pseudo severe aortic stenosis.

Author

Sokolovic S, Mundigler G, and Naser N

Subjects
Aortic Valve Stenosis physiopathology, Aortic Valve Stenosis surgery, Dobutamine, Female, Humans, Male, Middle Aged, Aortic Valve Stenosis diagnostic imaging, Echocardiography, Stress
Abstract

Purpose: To present the importance of stress echocardiography in diagnosis of low flow-low gradient aortic stenosis (AS)., Material and Method: Two patients were tested, one male patient, aged 62, weight 72 kg, height 172 cm, and BSA 1.86 cm2, and the other one was female, aged 59, weight 83 kg, height 168 cm and BSA, were found to have at least moderate ASs with low flow and low gradients at rest. Dobutamine stress test was performed using standard protocol starting at 2.5 mcg/kg/min at rest as continuous infusion and increasing every five minutes intervals with stepwise increase up to 20 mcg/kg/min. Monitoring with 12-lead ECG and blood pressure measurements at each step was performed. After completing the test, transthoracic echocardiography (TTE) showed in male patient increasing in transvalvular flow and gradients across aortic valve and ejection fraction (EF) measured by Simpson method increased from 33% at rest up to 40% following Dobutamine administration. EOA (effective aortic valve area) from 0.8 cm2 at rest increased insignificantly to 0.85 cm, (0.425 m2) afterwards., Conclusion: Final diagnosis therefore was severe aortic stenosis with preserved contractile reserve. The patient was scheduled for surgical valve replacement. In female patient after DST, the area of aortic valve increased significantly from 0.75 cm2 up to 1.05 cm2, while all transvalvular gradients remained almost unchanged. Pseudo-Aortic Stenosis and surgical valve replacement had not been indicated at this time.

Published
2010

40. Clinical, echocardiographic and echophonocardiographic characteristics of the atrial myxomas in 22 years period.

Author

Buksa M, Gerc V, Dilic M, Loza V, Naser N, Sokolovic S, Hodzic E, Brdjanovic S, and Kulic M

Subjects
Adult, Echocardiography, Echocardiography, Transesophageal, Female, Heart Atria diagnostic imaging, Heart Neoplasms diagnosis, Humans, Male, Myxoma diagnosis, Phonocardiography, Heart Neoplasms diagnostic imaging, Myxoma diagnostic imaging
Abstract

Introduction: Atrial myxomas are the most frequent benign tumors of the heart. Left atrial myxomas are about 3-4 times more frequent then right. Clinical findings reveal atrioventricular obstruction symptoms and signs, symptoms and signs of peripheral arteries or pulmonary artery embolisation and/or nonspecific symptoms., Aim: Review of atrial myxomas diagnosed at the Clinic of Cardiology in 20 years period and analysis of clinical characteristics, transthoracic echocardiographic (TTE), transesophageal echocardiographic (TEE), and M-mod echophonographic findings., Methods: TTE is performed in all, but TEE in 16 patients. Simultaneous M-mod echophonocardiographic examination were performed in 11 patients, when optional equipment was applicable., Results: We found 24 atrial myxomas: 19 (79.2%) in left and 5 (20.810%) in right atrium. 21(87.5%) patients had some of the symptoms, but 3 (12.5%) were asymptomatic. TTE was performed in all patients, but we found 1 (2.4%) false negative result. TEE was performed in 14 (58.3%) patients. Echophonocardiographic recordings showed early diastolic tumor "plop" in 10 patients and unusual late diastolic tumor "plop" in one right atrial myxoma, which has not yet been described., Conclusions: TTE is a reliable method in diagnosis of atrial myxomas, but not in all cases, while TEE has been found as always reliable. Echophonocardiographic recording is useful for confirmation and understanding of auscultatory finding when applicable.

Published
2009

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