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Since May 2022, 27,558 monkeypox cases have been identified in the United States (1). Gay, bisexual, and other men who have sex with men (MSM) represent the most affected demographic group in the current multinational outbreak (2). As of October 18, 2022, Louisiana had reported 273 monkeypox cases with 187 (68.5%) among residents of the Louisiana Department of Health (LDH) Southeast Region, which includes the city of New Orleans (3)., Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed.

Competing Interests: All authors have completed and submitted the ICMJE form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed.

A total of 1,007 Vibrio infections were reported to the Infectious Disease Epidemiology Department at the Louisiana Office of Public Heath, between 1980 and 2005. The most common were Vibrio vulnificus (257 infections), Vibrio parahemolyticus (249 infections), and Vibrio cholerae non O1 (200 cases). Other species were much less common. Vibrio vulnificus infections, which are associated with consumption of raw seafood (particularly oysters) or contact with sea water, and severe immuno-suppression or liver disease were increasing. Septicemia and blood stream infections are the main manifestations of this infection. The number of infections due to Vibrio parahemolyticus on the other hand, causing mostly gastroenteritis, has remained stable. Vibrio cholerae infections are less common and almost always associated with consumption of partially cooked or contaminated crabs.

Analysis of the influenza sentinel surveillance data from the Louisiana Office of Public health showed that the influenza season for Louisiana starts between October and December and ends between December and March. There is no consistent trend as to when the peak of the season occurs. The start of Louisiana's seasons ranged from one week (2002-2003 season) to two months (2001-2002) before the national start date. The finding that Louisiana's flu season starts about the same time as the national flu season is not consistent with the conventional thought that the flu season starts later in the South compared to the rest of the nation.

Estimating a prevalence of 1.8% of hepatitis C in the general population, there are in Louisiana about 81,000 individuals who have been infected with the hepatitis C virus. In 2002, the incidence of reported cases of acute hepatitis C was 2.2/100,000 versus 0.64 in the USA. The case register maintained by the Louisiana Office of Public Health has 22,000 cases. Building up a register of hepatitis C past or present infections is an important tool that may be used to resolve some important questions about the epidemiology of hepatitis C or be used for future preventive actions. Physicians and hospitals are encouraged to report hepatitis C infection including sufficient information to distinguish acute hepatitis C from hepatitis C past or present infection.

Analysis of the surveillance data from the Louisiana Office of Public Health showed a progressive decline of pertussis in Louisiana. Louisiana rates are lower than those of the United States, and increased rates observed among adults in other states are not observed in Louisiana. This would likely be due a lack of suspicion for pertussis in adults and a resultant lack of diagnosis and reporting. Two recent outbreak investigations in a health facility are summarily described, showing that pertussis is still a major cause of concern for the healthcare community.