16 results on '"Sokhal S"'
Search Results
2. CO-46 – Aspects cliniques, génotypiques et évolutifs de la maladie de gaucher chez l'enfant algérien
- Author
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Hadji, A., primary, Sokhal, S., additional, Cherif, S., additional, Kaabouche, L., additional, and Boukari, R., additional
- Published
- 2015
- Full Text
- View/download PDF
3. Characteristics of Gut Microbiome After Traumatic Brain Injury.
- Author
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Mahajan C, Khurana S, Kapoor I, Sokhal S, Kumar S, Prabhakar H, Mathur P, and Mani K
- Subjects
- Humans, Colistin, Anti-Bacterial Agents therapeutic use, Gastrointestinal Microbiome, Brain Injuries, Traumatic, Hypotension
- Abstract
Background: Preclinical studies have reported significant changes in the gut microbiome after traumatic brain injury (TBI). We hypothesized that TBI induces the growth of Proteobacteria in the human gut. Our primary outcome was to study the profile of the human fecal microbiome after TBI and the secondary outcome was to identify colonization with colistin-resistant and multidrug-resistant pathogens., Methods: Consecutive patients with moderate-severe TBI admitted to the neurotrauma-intensive care unit within 48 hours of injury were enrolled into this observational study. Samples from rectal swabs obtained on days 0, 3, and 7 after admission were assessed for microbial growth and antibiotic resistance. Demographic data and variables such as hypotension, blood transfusion, surgery, start of nasogastric feeding, use of antibiotics, length of hospital stay and mortality were noted., Results: One hundred one patients were enrolled into this study; 57 (56.4%) underwent surgery, 80 (79.2%) required blood transfusion, 15 (14.9%) had an episode of hypotension, 37 (36.6%) received enteral feed within the first 3 days, and 79 (78.2%) received antibiotics. Rectal microbiological samples were collected from 101, 95, and 85 patients on days 0, 3, and 7, respectively. All organisms isolated at the 3 time-points belonged to the Proteobacteria phylum, with Enterobacteriaceae forming the largest group. Colistin-resistant organisms were found in 17 (16.8%) of 101 patients and multidrug-resistant organisms in 25 (64.1%) of the 39 patients in whom isolates were tested against the entire panel of antimicrobials., Conclusion: TBI is associated with widespread colonization with Proteobacteria as early as 48 hours after injury. Colonization with colistin and multidrug-resistant organisms highlights the importance of the judicious use of antibiotics., Competing Interests: The authors have no funding or conflicts of interest to disclose., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
4. Fire Hazard in an Anesthesia Machine: A Case Report.
- Author
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Sokhal S, Sokhal N, Sharma P, and Chouhan RS
- Subjects
- Humans, Operating Rooms, Anesthesia adverse effects, Fires
- Abstract
An operating room (OR) fire is a rare event but may cause critical harm to patients and health care personnel. We present 2 fire incidents in the rear cabinet of an anesthesia machine, not previously reported in the literature. An anesthesia machine in standby mode is considered safer than in use, but in the first case, the fire occurred while the machine was on standby mode. In another case, the fire erupted while surgery was in progress. Here, we discuss the management of an anesthesia machine fire and emphasize the need for improved fire safety in advanced anesthesia machines., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2022 International Anesthesia Research Society.)
- Published
- 2022
- Full Text
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5. Inborn Errors of Immunity in Algerian Children and Adults: A Single-Center Experience Over a Period of 13 Years (2008-2021).
- Author
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Belaid B, Lamara Mahammed L, Drali O, Oussaid AM, Touri NS, Melzi S, Dehimi A, Berkani LM, Merah F, Larab Z, Allam I, Khemici O, Kirane SY, Boutaba M, Belbouab R, Bekkakcha H, Guedouar A, Chelali A, Baamara B, Noui D, Baaziz H, Rezak R, Azzouz SM, Aichaoui M, Moktefi A, Benhatchi RM, Oussalah M, Benaissa N, Laredj A, Bouchetara A, Adria A, Habireche B, Tounsi N, Dahmoun F, Touati R, Boucenna H, Bouferoua F, Sekfali L, Bouhafs N, Aboura R, Kherra S, Inouri Y, Dib S, Medouri N, Khelfaoui N, Redjedal A, Zelaci A, Yahiaoui S, Medjadj S, Touhami TK, Kadi A, Amireche F, Frada I, Houasnia S, Benarab K, Boubidi C, Ferhani Y, Benalioua H, Sokhal S, Benamar N, Aggoune S, Hadji K, Bellouti A, Rahmoune H, Boutrid N, Okka K, Ammour A, Saadoune H, Amroun M, Belhadj H, Ghanem A, Abbaz H, Boudrioua S, Zebiche B, Ayad A, Hamadache Z, Ouaras N, Achour N, Bouchair N, Boudiaf H, Bekkat-Berkani D, Maouche H, Bouzrar Z, Aissat L, Ibsaine O, Bioud B, Kedji L, Dahlouk D, Bensmina M, Radoui A, Bessahraoui M, Bensaadi N, Mekki A, Zeroual Z, Chan KW, Leung D, Tebaibia A, Ayoub S, Mekideche D, Gharnaout M, Casanova JL, Puel A, Lau YL, Cherif N, Ladj S, Smati L, Boukari R, Benhalla N, and Djidjik R
- Subjects
- Adult, Algeria epidemiology, Child, Female, Humans, Male, Retrospective Studies, Immunologic Deficiency Syndromes genetics, Primary Immunodeficiency Diseases genetics, Severe Combined Immunodeficiency
- Abstract
Background: Inborn errors of immunity (IEI) predispose patients to various infectious and non-infectious complications. Thanks to the development and expanding use of flow cytometry and increased awareness, the diagnostic rate of IEI has markedly increased in Algeria the last decade., Aim: This study aimed to describe a large cohort of Algerian patients with probable IEI and to determine their clinical characteristics and outcomes., Methods: We collected and analyzed retrospectively the demographic data, clinical manifestations, immunologic, genetic data, and outcome of Algerian IEI patients - diagnosed in the department of medical immunology of Beni Messous university hospital center, Algiers, from 2008 to 2021., Results: Eight hundred and seven patients with IEI (482 males and 325 females) were enrolled, 9.7% of whom were adults. Consanguinity was reported in 50.3% of the cases and a positive family history in 32.34%. The medium age at disease onset was 8 months and at diagnosis was 36 months. The median delay in diagnosis was 16 months. Combined immunodeficiencies were the most frequent (33.8%), followed by antibody deficiencies (24.5%) and well-defined syndromes with immunodeficiency (24%). Among 287 patients tested for genetic disorders, 129 patients carried pathogenic mutations; 102 having biallelic variants mostly in a homozygous state (autosomal recessive disorders). The highest mortality rate was observed in patients with combined immunodeficiency (70.1%), especially in patients with severe combined immunodeficiency (SCID), Omenn syndrome, or Major Histocompatibility Complex (MHC) class II deficiency., Conclusion: The spectrum of IEI in Algeria is similar to that seen in most countries of the Middle East and North Africa (MENA) region, notably regarding the frequency of autosomal recessive and/or combined immunodeficiencies., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Belaid, Lamara Mahammed, Drali, Oussaid, Touri, Melzi, Dehimi, Berkani, Merah, Larab, Allam, Khemici, Kirane, Boutaba, Belbouab, Bekkakcha, Guedouar, Chelali, Baamara, Noui, Baaziz, Rezak, Azzouz, Aichaoui, Moktefi, Benhatchi, Oussalah, Benaissa, Laredj, Bouchetara, Adria, Habireche, Tounsi, Dahmoun, Touati, Boucenna, Bouferoua, Sekfali, Bouhafs, Aboura, Kherra, Inouri, Dib, Medouri, Khelfaoui, Redjedal, Zelaci, Yahiaoui, Medjadj, Touhami, Kadi, Amireche, Frada, Houasnia, Benarab, Boubidi, Ferhani, Benalioua, Sokhal, Benamar, Aggoune, Hadji, Bellouti, Rahmoune, Boutrid, Okka, Ammour, Saadoune, Amroun, Belhadj, Ghanem, Abbaz, Boudrioua, Zebiche, Ayad, Hamadache, Ouaras, Achour, Bouchair, Boudiaf, Bekkat-Berkani, Maouche, Bouzrar, Aissat, Ibsaine, Bioud, Kedji, Dahlouk, Bensmina, Radoui, Bessahraoui, Bensaadi, Mekki, Zeroual, Chan, Leung, Tebaibia, Ayoub, Mekideche, Gharnaout, Casanova, Puel, Lau, Cherif, Ladj, Smati, Boukari, Benhalla and Djidjik.)
- Published
- 2022
- Full Text
- View/download PDF
6. Perioperative Management of a Patient with Chin-On-Chest Deformity Presenting for Reconstructive Spine Surgery.
- Author
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Khandelwal A, Sokhal S, Dube SK, Goyal K, Singh A, Tandon V, Phalak M, Chaturvedi A, and Kale SS
- Subjects
- Cervical Vertebrae, Chin, Humans, Treatment Outcome, Kyphosis, Spondylitis, Ankylosing complications, Spondylitis, Ankylosing surgery
- Abstract
Chin-on- chest deformity is not uncommon sequelae of ankylosing spondylitis. Apart from difficult airway, several other considerations might include co-existing cardio-respiratory embarrassment, osteoporotic bones, and neurological perturbations. We describe the successful anesthetic management of a case of chin-on-chest deformity with no access to midline neck structures and extremely difficult airway posted for corrective spine surgery., Competing Interests: None
- Published
- 2021
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7. Ultrasound-guided peripheral artery cannulation: A priority, not an option.
- Author
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Sokhal N, Khandelwal A, Sokhal S, and Chaturvedi A
- Abstract
Competing Interests: There are no conflicts of interest.
- Published
- 2020
- Full Text
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8. Intraoperative Management of a Patient for Deep Brain Stimulation with Severe Dyskinesia and Tremors: Ketamine to the Rescue!
- Author
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Sokhal S, Goyal K, Sokhal N, Kumar N, and Kedia S
- Abstract
The loss of dopaminergic neurons from the substantia nigra pars compacta characterizes the classical pathology of Parkinson's disease (PD). Deep brain stimulation (DBS) has become an increasingly common treatment for PD. Sometimes excessive tremors due to exacerbated PD hinder the surgery and may almost make it impossible. This is a case report highlights use of IV ketamine for intraoperative sedation of a patient with PD, with severe dyskinesia & tremors, posted for DBS. IV ketamine resulted in prompt abolition of tremors and dyskinesia, which were unresponsive to previous traditional sedative drugs., Competing Interests: There are no conflicts of interest., (Copyright: © 2019 Asian Journal of Neurosurgery.)
- Published
- 2019
- Full Text
- View/download PDF
9. Iatrogenic Seizures during Intraoperative Transcranial Motor-Evoked Potential Monitoring.
- Author
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Sokhal S, Goyal K, Sokhal N, Kumar N, and Kedia S
- Abstract
Intraoperative neurophysiological monitoring (IONM) is an important tool for early detection of inadvertent damage and guide intra-operative manipulation during complex neurosurgical procedures. However trans-cranial stimulation can evoke an iatrogenic seizure and it remains a real concern while using Tc-MEP. We report a case of intra-operative seizure during transcranial electrical stimulation for motor evoked potential monitoring in a patient without seizure disorder, who underwent surgery for thoracic intra-medullary tumor excision., Competing Interests: There are no conflicts of interest.
- Published
- 2019
- Full Text
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10. Reflex bradycardia due to traction on filum terminale during detethering of spinal cord.
- Author
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Chavali S, Das K, Sokhal S, and Rath GP
- Subjects
- Adolescent, Female, Humans, Bradycardia etiology, Cauda Equina, Intraoperative Complications etiology, Neurosurgical Procedures adverse effects, Spinal Cord Diseases surgery, Traction adverse effects
- Abstract
Competing Interests: There are no conflicts of interest
- Published
- 2019
- Full Text
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11. Phenytoin-induced Excessive Sedation During Awake Craniotomy: An Unusual Observation.
- Author
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Khandelwal A, Sokhal N, Kumar N, Singh S, and Sokhal S
- Subjects
- Adult, Brain Neoplasms surgery, Consciousness Monitors, Glioma surgery, Humans, Male, Wakefulness, Conscious Sedation adverse effects, Craniotomy, Muscle Relaxants, Central adverse effects, Phenytoin adverse effects
- Published
- 2019
- Full Text
- View/download PDF
12. Efficacy and safety of dexmedetomidine infusion for patients undergoing awake craniotomy: An observational study.
- Author
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Mahajan C, Rath GP, Singh GP, Mishra N, Sokhal S, and Bithal PK
- Abstract
Background: The goal of awake craniotomy is to maintain adequate sedation, analgesia, respiratory, and hemodynamic stability and also to provide a cooperative patient for neurologic testing. An observational study carried out to evaluate the efficacy of dexmedetomidine sedation for awake craniotomy., Materials and Methods: Adult patients with age >18 year who underwent awake craniotomy for intracranial tumor surgery were enrolled. Those who were uncooperative and had difficult airway were excluded from the study. In the operating room, the patients received a bolus dose of dexmedetomidine 1 μg/kg followed by an infusion of 0.2-0.7 μg/kg/h (bispectral index target 60-80). Once the patients were sedated, scalp block was given with bupivacaine 0.25%. The data on hemodynamics at various stages of the procedure, intraoperative complications, total amount of fentanyl used, intravenous fluids required, blood loss and transfusion, duration of surgery, Intensive Care Unit (ICU), and hospital stay were collected. The patients were assessed for Glasgow outcome scale (GOS) score and patient satisfaction score (PSS)., Results: A total of 27 patients underwent awake craniotomy during a period of 2 years. Most common intraoperative complication was seizures; observed in five patients (18.5%). None of these patients experienced any episode of desaturation. Two patients had tight brain for which propofol boluses were administered. The average fentanyl consumption was 161.5 ± 85.0 μg. The duration of surgery, ICU, and hospital stays were 231.5 ± 90.5 min, 14.5 ± 3.5 h, and 4.7 ± 1.5 days, respectively. The overall PSS was 8 and GOS was good in all the patients., Conclusion: The use of dexmedetomidine infusion with regional scalp block in patients undergoing awake craniotomy is safe and efficacious. The absence of major complications and higher PSS makes it close to an ideal agent for craniotomy in awake state., Competing Interests: There are no conflicts of interest.
- Published
- 2018
- Full Text
- View/download PDF
13. Tetanus Immunity among Women Aged 15 to 39 Years in Cambodia: a National Population-Based Serosurvey, 2012.
- Author
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Scobie HM, Mao B, Buth S, Wannemuehler KA, Sørensen C, Kannarath C, Jenks MH, Moss DM, Priest JW, Soeung SC, Deming MS, Lammie PJ, and Gregory CJ
- Subjects
- Adolescent, Adult, Cambodia, Female, Humans, Immunoassay methods, Young Adult, Antibodies, Bacterial blood, Antitoxins blood, Tetanus immunology, Tetanus prevention & control
- Abstract
To monitor progress toward maternal and neonatal tetanus elimination (MNTE) in Cambodia, we conducted a nationwide serosurvey of tetanus immunity in 2012. Multistage cluster sampling was used to select 2,154 women aged 15 to 39 years. Tetanus toxoid antibodies in serum samples were measured by gold-standard double-antigen enzyme-linked immunosorbent assay (DAE) and a novel multiplex bead assay (MBA). Antibody concentrations of ≥0.01 IU/ml by DAE or the equivalent for MBA were considered seroprotective. Estimated tetanus seroprotection was 88% (95% confidence interval [CI], 86 to 89%); 64% (95% CI, 61 to 67%) of women had antibody levels of ≥1.0 IU/ml. Seroprotection was significantly lower (P < 0.001) among women aged 15 to 19 years (63%) and 20 to 24 years (87%) than among those aged ≥25 years (96%), among nulliparous women than among parous women (71 versus 97%), and among those living in the western region than among those living in other regions (82 versus 89%). The MBA showed high sensitivity (99% [95% CI, 98 to 99%]) and specificity (92% [95% CI, 88 to 95%]) compared with DAE. Findings were compatible with MNTE in Cambodia (≥80% protection). Tetanus immunity gaps should be addressed through strengthened routine immunization and targeted vaccination campaigns. Incorporating tetanus testing in national serosurveys using MBAs, which can measure immunity to multiple pathogens simultaneously, may be beneficial for monitoring MNTE., (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)
- Published
- 2016
- Full Text
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14. Integration of Multiplex Bead Assays for Parasitic Diseases into a National, Population-Based Serosurvey of Women 15-39 Years of Age in Cambodia.
- Author
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Priest JW, Jenks MH, Moss DM, Mao B, Buth S, Wannemuehler K, Soeung SC, Lucchi NW, Udhayakumar V, Gregory CJ, Huy R, Muth S, and Lammie PJ
- Subjects
- Adolescent, Adult, Animals, Antibodies, Bacterial blood, Antibodies, Viral blood, Cambodia epidemiology, Female, Health Surveys, Humans, Microspheres, Neglected Diseases epidemiology, Plasmodium immunology, Sensitivity and Specificity, Seroepidemiologic Studies, Strongyloides stercoralis immunology, Taenia solium immunology, Toxoplasma immunology, Wuchereria bancrofti immunology, Young Adult, Antibodies, Helminth blood, Antibodies, Protozoan blood, Helminthiasis epidemiology, Immunoglobulin G blood, Malaria epidemiology, Toxoplasmosis epidemiology
- Abstract
Collection of surveillance data is essential for monitoring and evaluation of public health programs. Integrated collection of household-based health data, now routinely carried out in many countries through demographic health surveys and multiple indicator surveys, provides critical measures of progress in health delivery. In contrast, biomarker surveys typically focus on single or related measures of malaria infection, HIV status, vaccination coverage, or immunity status for vaccine-preventable diseases (VPD). Here we describe an integrated biomarker survey based on use of a multiplex bead assay (MBA) to simultaneously measure antibody responses to multiple parasitic diseases of public health importance as part of a VPD serological survey in Cambodia. A nationally-representative cluster-based survey was used to collect serum samples from women of child-bearing age. Samples were tested by MBA for immunoglobulin G antibodies recognizing recombinant antigens from Plasmodium falciparum and P. vivax, Wuchereria bancrofti, Toxoplasma gondii, Taenia solium, and Strongyloides stercoralis. Serologic IgG antibody results were useful both for generating national prevalence estimates for the parasitic diseases of interest and for confirming the highly focal distributions of some of these infections. Integrated surveys offer an opportunity to systematically assess the status of multiple public health programs and measure progress toward Millennium Development Goals.
- Published
- 2016
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15. A novel use of nasopharyngeal airway in managing airway leak.
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Saxena A, Tomar GS, Sokhal S, and Singh N
- Abstract
We report a case of severe maxillofacial injury, who while undergoing later stages of reconstruction surgeries, presented with an inimitable kind of air leak during mask ventilation and its interesting management using a nasopharyngeal airway. The case also enlightens the importance of evaluating the available computed tomography images as a part of preanesthetic check-up.
- Published
- 2015
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16. Unusual difficulty during central venous catheterization.
- Author
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Sokhal N, Sokhal S, and Chowdhury T
- Published
- 2012
- Full Text
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