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1. Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Author

Schiffner, Torben, Phung, Ivy, Ray, Rashmi, Irimia, Adriana, Tian, Ming, Swanson, Olivia, Lee, Jeong Hyun, Lee, Chang-Chun D., Marina-Zárate, Ester, Cho, So Yeon, Huang, Jiachen, Ozorowski, Gabriel, Skog, Patrick D., Serra, Andreia M., Rantalainen, Kimmo, Allen, Joel D., Baboo, Sabyasachi, Rodriguez, Oscar L., Himansu, Sunny, Zhou, Jianfu, Hurtado, Jonathan, Flynn, Claudia T., McKenney, Katherine, Havenar-Daughton, Colin, Saha, Swati, Shields, Kaitlyn, Schultze, Steven, Smith, Melissa L., Liang, Chi-Hui, Toy, Laura, Pecetta, Simone, Lin, Ying-Cing, Willis, Jordan R., Sesterhenn, Fabian, Kulp, Daniel W., Hu, Xiaozhen, Cottrell, Christopher A., Zhou, Xiaoya, Ruiz, Jennifer, Wang, Xuesong, Nair, Usha, Kirsch, Kathrin H., Cheng, Hwei-Ling, Davis, Jillian, Kalyuzhniy, Oleksandr, Liguori, Alessia, Diedrich, Jolene K., Ngo, Julia T., Lewis, Vanessa, Phelps, Nicole, Tingle, Ryan D., Spencer, Skye, Georgeson, Erik, Adachi, Yumiko, Kubitz, Michael, Eskandarzadeh, Saman, Elsliger, Marc A., Amara, Rama R., Landais, Elise, Briney, Bryan, Burton, Dennis R., Carnathan, Diane G., Silvestri, Guido, Watson, Corey T., Yates, III, John R., Paulson, James C., Crispin, Max, Grigoryan, Gevorg, Ward, Andrew B., Sok, Devin, Alt, Frederick W., Wilson, Ian A., Batista, Facundo D., Crotty, Shane, and Schief, William R.

Published
2024
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2. Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies

Author

Joyce, Collin, Murrell, Sasha, Murrell, Ben, Omorodion, Oluwarotimi, Ver, Lorena S, Carrico, Nancy, Bastidas, Raiza, Nedellec, Rebecca, Bick, Michael, Woehl, Jordan, Zhao, Fangzhu, Burns, Alison, Barman, Shawn, Appel, Michael, Ramos, Alejandra, Wickramasinghe, Lalinda, Eren, Kemal, Vollbrecht, Thomas, Smith, Davey M, Pond, Sergei L Kosakovsky, McBride, Ryan, Worth, Charli, Batista, Facundo, Sok, Devin, Network, The IAVI Protocol C Investigators The IAVI African HIV Research, Poignard, Pascal, Briney, Bryan, Wilson, Ian A, Landais, Elise, and Burton, Dennis R

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Vaccine Related, Immunization, Vaccine Related (AIDS), Infectious Diseases, Biotechnology, Prevention, Sexually Transmitted Infections, HIV/AIDS, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Humans, Broadly Neutralizing Antibodies, HIV Antibodies, HIV Infections, Epitopes, Dermatitis, HIV-1, IAVI Protocol C Investigators & The IAVI African HIV Research Network, Microbiology, Virology, Medical microbiology
Abstract

Vaccination strategies aimed at maturing broadly neutralizing antibodies (bnAbs) from naïve precursors are hindered by unusual features that characterize these Abs, including insertions and deletions (indels). Longitudinal studies of natural HIV infection cases shed light on the complex processes underlying bnAb development and have suggested a role for superinfection as a potential enhancer of neutralization breadth. Here we describe the development of a potent bnAb lineage that was elicited by two founder viruses to inform vaccine design. The V3-glycan targeting bnAb lineage (PC39-1) was isolated from subtype C-infected IAVI Protocol C elite neutralizer, donor PC39, and is defined by the presence of multiple independent insertions in CDRH1 that range from 1-11 amino acids in length. Memory B cell members of this lineage are predominantly atypical in phenotype yet also span the class-switched and antibody-secreting cell compartments. Development of neutralization breadth occurred concomitantly with extensive recombination between founder viruses before each virus separated into two distinct population "arms" that evolved independently to escape the PC39-1 lineage. Ab crystal structures show an extended CDRH1 that can help stabilize the CDRH3. Overall, these findings suggest that early exposure of the humoral system to multiple related Env molecules could promote the induction of bnAbs by focusing Ab responses to conserved epitopes.

Published
2023

3. Author Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41

Author

Schiffner, Torben, Phung, Ivy, Ray, Rashmi, Irimia, Adriana, Tian, Ming, Swanson, Olivia, Lee, Jeong Hyun, Lee, Chang-Chun D., Marina-Zárate, Ester, Cho, So Yeon, Huang, Jiachen, Ozorowski, Gabriel, Skog, Patrick D., Serra, Andreia M., Rantalainen, Kimmo, Allen, Joel D., Baboo, Sabyasachi, Rodriguez, Oscar L., Himansu, Sunny, Zhou, Jianfu, Hurtado, Jonathan, Flynn, Claudia T., McKenney, Katherine, Havenar-Daughton, Colin, Saha, Swati, Shields, Kaitlyn, Schultze, Steven, Smith, Melissa L., Liang, Chi-Hui, Toy, Laura, Pecetta, Simone, Lin, Ying-Cing, Willis, Jordan R., Sesterhenn, Fabian, Kulp, Daniel W., Hu, Xiaozhen, Cottrell, Christopher A., Zhou, Xiaoya, Ruiz, Jennifer, Wang, Xuesong, Nair, Usha, Kirsch, Kathrin H., Cheng, Hwei-Ling, Davis, Jillian, Kalyuzhniy, Oleksandr, Liguori, Alessia, Diedrich, Jolene K., Ngo, Julia T., Lewis, Vanessa, Phelps, Nicole, Tingle, Ryan D., Spencer, Skye, Georgeson, Erik, Adachi, Yumiko, Kubitz, Michael, Eskandarzadeh, Saman, Elsliger, Marc A., Amara, Rama R., Landais, Elise, Briney, Bryan, Burton, Dennis R., Carnathan, Diane G., Silvestri, Guido, Watson, Corey T., Yates, III, John R., Paulson, James C., Crispin, Max, Grigoryan, Gevorg, Ward, Andrew B., Sok, Devin, Alt, Frederick W., Wilson, Ian A., Batista, Facundo D., Crotty, Shane, and Schief, William R.

Published
2024
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4. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

Author

Rogers, Thomas F, Zhao, Fangzhu, Huang, Deli, Beutler, Nathan, Burns, Alison, He, Wan-Ting, Limbo, Oliver, Smith, Chloe, Song, Ge, Woehl, Jordan, Yang, Linlin, Abbott, Robert K, Callaghan, Sean, Garcia, Elijah, Hurtado, Jonathan, Parren, Mara, Peng, Linghang, Ramirez, Sydney, Ricketts, James, Ricciardi, Michael J, Rawlings, Stephen A, Wu, Nicholas C, Yuan, Meng, Smith, Davey M, Nemazee, David, Teijaro, John R, Voss, James E, Wilson, Ian A, Andrabi, Raiees, Briney, Bryan, Landais, Elise, Sok, Devin, Jardine, Joseph G, and Burton, Dennis R

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Vaccine Related, Biotechnology, Emerging Infectious Diseases, Coronaviruses Vaccines, Infectious Diseases, Prevention, Coronaviruses, Lung, Immunization, 5.1 Pharmaceuticals, Good Health and Well Being, Adult, Angiotensin-Converting Enzyme 2, Animals, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antibody Affinity, Antibody Specificity, Betacoronavirus, Binding Sites, COVID-19, Cell Line, Coronavirus Infections, Disease Models, Animal, Epitopes, Female, Humans, Immunization, Passive, Male, Mesocricetus, Middle Aged, Neutralization Tests, Pandemics, Peptidyl-Dipeptidase A, Pneumonia, Viral, Protein Domains, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Viral Load, Virus Replication, COVID-19 Serotherapy, General Science & Technology
Abstract

Countermeasures to prevent and treat coronavirus disease 2019 (COVID-19) are a global health priority. We enrolled a cohort of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-recovered participants, developed neutralization assays to investigate antibody responses, adapted our high-throughput antibody generation pipeline to rapidly screen more than 1800 antibodies, and established an animal model to test protection. We isolated potent neutralizing antibodies (nAbs) to two epitopes on the receptor binding domain (RBD) and to distinct non-RBD epitopes on the spike (S) protein. As indicated by maintained weight and low lung viral titers in treated animals, the passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters. The study suggests a role for nAbs in prophylaxis, and potentially therapy, of COVID-19. The nAbs also define protective epitopes to guide vaccine design.

Published
2020

5. Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

Author

Rogers, Thomas F, Zhao, Fangzhu, Huang, Deli, Beutler, Nathan, Burns, Alison, He, Wan-Ting, Limbo, Oliver, Smith, Chloe, Song, Ge, Woehl, Jordan, Yang, Linlin, Abbott, Robert K, Callaghan, Sean, Garcia, Elijah, Hurtado, Jonathan, Parren, Mara, Peng, Linghang, Ricketts, James, Ricciardi, Michael J, Rawlings, Stephen A, Smith, Davey M, Nemazee, David, Teijaro, John R, Voss, James E, Andrabi, Raiees, Briney, Bryan, Landais, Elise, Sok, Devin, Jardine, Joseph G, and Burton, Dennis R

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Vaccine Related, Biotechnology, Emerging Infectious Diseases, Coronaviruses Vaccines, Infectious Diseases, Prevention, Coronaviruses, Immunization, Good Health and Well Being
Abstract

The development of countermeasures to prevent and treat COVID-19 is a global health priority. In under 7 weeks, we enrolled a cohort of SARS-CoV-2-recovered participants, developed neutralization assays to interrogate serum and monoclonal antibody responses, adapted our high throughput antibody isolation, production and characterization pipeline to rapidly screen over 1000 antigen-specific antibodies, and established an animal model to test protection. We report multiple highly potent neutralizing antibodies (nAbs) and show that passive transfer of a nAb provides protection against high-dose SARS-CoV-2 challenge in Syrian hamsters. The study suggests a role for nAbs in prophylaxis, and potentially therapy, of COVID-19. The nAbs define protective epitopes to guide vaccine design.

Published
2020

6. Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

Author

Zhao, Fangzhu, Keating, Celina, Ozorowski, Gabriel, Shaabani, Namir, Francino-Urdaniz, Irene M., Barman, Shawn, Limbo, Oliver, Burns, Alison, Zhou, Panpan, Ricciardi, Michael J., Woehl, Jordan, Tran, Quoc, Turner, Hannah L., Peng, Linghang, Huang, Deli, Nemazee, David, Andrabi, Raiees, Sok, Devin, Teijaro, John R., Whitehead, Timothy A., Ward, Andrew B., Burton, Dennis R., and Jardine, Joseph G.

Published
2022
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8. Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

Author

Zhao, Fangzhu, Berndsen, Zachary T., Pedreño-Lopez, Nuria, Burns, Alison, Allen, Joel D., Barman, Shawn, Lee, Wen-Hsin, Chakraborty, Srirupa, Gnanakaran, Sandrasegaram, Sewall, Leigh M., Ozorowski, Gabriel, Limbo, Oliver, Song, Ge, Yong, Peter, Callaghan, Sean, Coppola, Jessica, Weisgrau, Kim L., Lifson, Jeffrey D., Nedellec, Rebecca, Voigt, Thomas B., Laurino, Fernanda, Louw, Johan, Rosen, Brandon C., Ricciardi, Michael, Crispin, Max, Desrosiers, Ronald C., Rakasz, Eva G., Watkins, David I., Andrabi, Raiees, Ward, Andrew B., Burton, Dennis R., and Sok, Devin

Published
2022
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9. Identification of IOMA-class neutralizing antibodies targeting the CD4-binding site on the HIV-1 envelope glycoprotein

Author

van Schooten, Jelle, Farokhi, Elinaz, Schorcht, Anna, van den Kerkhof, Tom L. G. M., Gao, Hongmei, van der Woude, Patricia, Burger, Judith A., Meesters, Tim G. Rijkhold, Bijl, Tom, Ghalaiyini, Riham, Turner, Hannah L., Dorning, Jessica, van Schaik, Barbera D. C., van Kampen, Antoine H. C., Labranche, Celia C., Stanfield, Robyn L., Sok, Devin, Montefiori, David C., Burton, Dennis R., Seaman, Michael S., Ozorowski, Gabriel, Wilson, Ian A., Sanders, Rogier W., Ward, Andrew B., and van Gils, Marit J.

Published
2022
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12. Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

Author

Freund, Natalia T, Wang, Haoqing, Scharf, Louise, Nogueira, Lilian, Horwitz, Joshua A, Bar-On, Yotam, Golijanin, Jovana, Sievers, Stuart A, Sok, Devin, Cai, Hui, Cesar Lorenzi, Julio C, Halper-Stromberg, Ariel, Toth, Ildiko, Piechocka-Trocha, Alicja, Gristick, Harry B, van Gils, Marit J, Sanders, Rogier W, Wang, Lai-Xi, Seaman, Michael S, Burton, Dennis R, Gazumyan, Anna, Walker, Bruce D, West, Anthony P, Bjorkman, Pamela J, and Nussenzweig, Michel C

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Prevention, Vaccine Related, Vaccine Related (AIDS), Infectious Diseases, Sexually Transmitted Infections, Biotechnology, Immunization, HIV/AIDS, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Animals, Antibodies, Neutralizing, B-Lymphocytes, Cohort Studies, Crystallography, X-Ray, Epitopes, HEK293 Cells, HIV Antibodies, HIV Infections, HIV-1, HLA-B Antigens, HLA-B27 Antigen, Humans, Mice, Mice, Transgenic, Neutralization Tests, Viral Load, Viremia, env Gene Products, Human Immunodeficiency Virus, Biological Sciences, Medical and Health Sciences, Medical biotechnology, Biomedical engineering
Abstract

Some HIV-1-infected patients develop broad and potent HIV-1 neutralizing antibodies (bNAbs) that when passively transferred to mice or macaques can treat or prevent infection. However, bNAbs typically fail to neutralize coexisting autologous viruses due to antibody-mediated selection against sensitive viral strains. We describe an HIV-1 controller expressing HLA-B57*01 and HLA-B27*05 who maintained low viral loads for 30 years after infection and developed broad and potent serologic activity against HIV-1. Neutralization was attributed to three different bNAbs targeting nonoverlapping sites on the HIV-1 envelope trimer (Env). One of the three, BG18, an antibody directed against the glycan-V3 portion of Env, is the most potent member of this class reported to date and, as revealed by crystallography and electron microscopy, recognizes HIV-1 Env in a manner that is distinct from other bNAbs in this class. Single-genome sequencing of HIV-1 from serum samples obtained over a period of 9 years showed a diverse group of circulating viruses, 88.5% (31 of 35) of which remained sensitive to at least one of the temporally coincident autologous bNAbs and the individual's serum. Thus, bNAb-sensitive strains of HIV-1 coexist with potent neutralizing antibodies that target the virus and may contribute to control in this individual. When administered as a mix, the three bNAbs controlled viremia in HIV-1YU2-infected humanized mice. Our finding suggests that combinations of bNAbs may contribute to control of HIV-1 infection.

Published
2017

14. Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Author

Foss, Stian, primary, Sakya, Siri A., additional, Aguinagalde, Leire, additional, Lustig, Marta, additional, Shaughnessy, Jutamas, additional, Cruz, Ana Rita, additional, Scheepmaker, Lisette, additional, Mathiesen, Line, additional, Ruso-Julve, Fulgencio, additional, Anthi, Aina Karen, additional, Gjølberg, Torleif Tollefsrud, additional, Mester, Simone, additional, Bern, Malin, additional, Evers, Mitchell, additional, Bratlie, Diane B., additional, Michaelsen, Terje E., additional, Schlothauer, Tilman, additional, Sok, Devin, additional, Bhattacharya, Jayanta, additional, Leusen, Jeanette, additional, Valerius, Thomas, additional, Ram, Sanjay, additional, Rooijakkers, Suzan H. M., additional, Sandlie, Inger, additional, and Andersen, Jan Terje, additional

Published
2024
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15. Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

Author

Khalek, Irene S., primary, Senji Laxme, R. R., additional, Nguyen, Yen Thi Kim, additional, Khochare, Suyog, additional, Patel, Rohit N., additional, Woehl, Jordan, additional, Smith, Jessica M., additional, Saye-Francisco, Karen, additional, Kim, Yoojin, additional, Misson Mindrebo, Laetitia, additional, Tran, Quoc, additional, Kędzior, Mateusz, additional, Boré, Evy, additional, Limbo, Oliver, additional, Verma, Megan, additional, Stanfield, Robyn L., additional, Menzies, Stefanie K., additional, Ainsworth, Stuart, additional, Harrison, Robert A., additional, Burton, Dennis R., additional, Sok, Devin, additional, Wilson, Ian A., additional, Casewell, Nicholas R., additional, Sunagar, Kartik, additional, and Jardine, Joseph G., additional

Published
2024
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16. Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire

Author

Altman, Pilar X., primary, Ozorowski, Gabriel, additional, Stanfield, Robyn L., additional, Haakenson, Jeremy, additional, Appel, Michael, additional, Parren, Mara, additional, Lee, Wen-Hsin, additional, Sang, Huldah, additional, Woehl, Jordan, additional, Saye-Francisco, Karen, additional, Joyce, Collin, additional, Song, Ge, additional, Porter, Katelyn, additional, Landais, Elise, additional, Andrabi, Raiees, additional, Wilson, Ian A., additional, Ward, Andrew B., additional, Mwangi, Waithaka, additional, Smider, Vaughn V., additional, Burton, Dennis R., additional, and Sok, Devin, additional

Published
2024
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17. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

Author

Steichen, Jon M., Lin, Ying-Cing, Havenar-Daughton, Colin, Pecetta, Simone, Ozorowski, Gabriel, Willis, Jordan R., Toy, Laura, Sok, Devin, Liguori, Alessia, Kratochvil, Sven, Torres, Jonathan L., Kalyuzhniy, Oleksandr, Melzi, Eleonora, Kulp, Daniel W., Raemisch, Sebastian, Hu, Xiaozhen, Bernard, Steffen M., Georgeson, Erik, Phelps, Nicole, Adachi, Yumiko, Kubitz, Michael, Landais, Elise, Umotoy, Jeffrey, Robinson, Amanda, Briney, Bryan, Wilson, Ian A., Burton, Dennis R., Ward, Andrew B., Crotty, Shane, Batista, Facundo D., and Schief, William R.

Published
2019

18. Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Author

MMB Research line 1, CTI Leusen, Infection & Immunity, Cancer, Foss, Stian, Sakya, Siri A, Aguinagalde, Leire, Lustig, Marta, Shaughnessy, Jutamas, Cruz, Ana Rita, Scheepmaker, Lisette, Mathiesen, Line, Ruso-Julve, Fulgencio, Anthi, Aina Karen, Gjølberg, Torleif Tollefsrud, Mester, Simone, Bern, Malin, Evers, Mitchell, Bratlie, Diane B, Michaelsen, Terje E, Schlothauer, Tilman, Sok, Devin, Bhattacharya, Jayanta, Leusen, Jeanette, Valerius, Thomas, Ram, Sanjay, Rooijakkers, Suzan H M, Sandlie, Inger, Andersen, Jan Terje, MMB Research line 1, CTI Leusen, Infection & Immunity, Cancer, Foss, Stian, Sakya, Siri A, Aguinagalde, Leire, Lustig, Marta, Shaughnessy, Jutamas, Cruz, Ana Rita, Scheepmaker, Lisette, Mathiesen, Line, Ruso-Julve, Fulgencio, Anthi, Aina Karen, Gjølberg, Torleif Tollefsrud, Mester, Simone, Bern, Malin, Evers, Mitchell, Bratlie, Diane B, Michaelsen, Terje E, Schlothauer, Tilman, Sok, Devin, Bhattacharya, Jayanta, Leusen, Jeanette, Valerius, Thomas, Ram, Sanjay, Rooijakkers, Suzan H M, Sandlie, Inger, and Andersen, Jan Terje

Published
2024

19. Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Author

Foss, Stian, Sakya, Siri A., Aguinagalde, Leire, Lustig, Marta, Shaughnessy, Jutamas, Cruz, Ana Rita, Scheepmaker, Lisette, Mathiesen, Line, Ruso-Julve, Fulgencio, Anthi, Aina Karen, Gjølberg, Torleif Tollefsrud, Mester, Simone, Bern, Malin, Evers, Mitchell, Bratlie, Diane B., Michaelsen, Terje E., Schlothauer, Tilman, Sok, Devin, Bhattacharya, Jayanta, Leusen, Jeanette, Valerius, Thomas, Ram, Sanjay, Rooijakkers, Suzan H.M., Sandlie, Inger, Andersen, Jan Terje, Foss, Stian, Sakya, Siri A., Aguinagalde, Leire, Lustig, Marta, Shaughnessy, Jutamas, Cruz, Ana Rita, Scheepmaker, Lisette, Mathiesen, Line, Ruso-Julve, Fulgencio, Anthi, Aina Karen, Gjølberg, Torleif Tollefsrud, Mester, Simone, Bern, Malin, Evers, Mitchell, Bratlie, Diane B., Michaelsen, Terje E., Schlothauer, Tilman, Sok, Devin, Bhattacharya, Jayanta, Leusen, Jeanette, Valerius, Thomas, Ram, Sanjay, Rooijakkers, Suzan H.M., Sandlie, Inger, and Andersen, Jan Terje

Abstract

Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequency of administration and thereby potentially patient compliance. Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice. In addition, the Fc-engineered variant improves on-target complement-mediated killing of cancer cells as well as both gram-positive and gram-negative bacteria. Hence, this versatile Fc technology should be broadly applicable in antibody design aiming for long-acting prophylactic or therapeutic interventions.

Published
2024

20. Neutralization diversity of HIV-1 Indian subtype C envelopes obtained from cross sectional and followed up individuals against broadly neutralizing monoclonal antibodies having distinct gp120 specificities

Author

Mullick, Ranajoy, Sutar, Jyoti, Hingankar, Nitin, Deshpande, Suprit, Thakar, Madhuri, Sahay, Seema, Ringe, Rajesh P., Mukhopadhyay, Sampurna, Patil, Ajit, Bichare, Shubhangi, Murugavel, Kailapuri G., Srikrishnan, Aylur K., Goyal, Rajat, Sok, Devin, and Bhattacharya, Jayanta

Published
2021
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22. Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan

Author

Umotoy, Jeffrey, Bagaya, Bernard S., Joyce, Collin, Schiffner, Torben, Menis, Sergey, Saye-Francisco, Karen L., Biddle, Trevor, Mohan, Sanjay, Vollbrecht, Thomas, Kalyuzhniy, Oleksander, Madzorera, Sharon, Kitchin, Dale, Lambson, Bronwen, Nonyane, Molati, Kilembe, William, Poignard, Pascal, Schief, William R., Burton, Dennis R., Murrell, Ben, Moore, Penny L., Briney, Bryan, Sok, Devin, and Landais, Elise

Published
2019
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23. Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

Author

Schiffner, Torben, primary, Palser, Anne, additional, Jardine, Joseph G., additional, Liguori, Alessia, additional, Menis, Sergey, additional, Raemisch, Sebastian, additional, Hu, Xiaozhen, additional, Kulp, Daniel W., additional, Wang, Xiaoning, additional, Diedrich, Jolene K., additional, Groschel, Bettina, additional, Kalyuzhniy, Oleksandr, additional, Tingle, Ryan, additional, Le, Khoa, additional, Georgeson, Erik, additional, Adachi, Yumiko, additional, Kubitz, Michael, additional, Landais, Elise, additional, Yates, John R., additional, Paulson, James C., additional, Sok, Devin, additional, Kellam, Paul, additional, and Schief, William R., additional

Published
2024
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24. Cost-effectiveness of broadly neutralizing antibodies for infant HIV prophylaxis in settings with high HIV burdens: a simulation modeling study

Author

Alba, Christopher, primary, Malhotra, Shelly, additional, Horsfall, Stephanie, additional, Barnhart, Matthew E., additional, Bekker, Adrie, additional, Chapman, Katerina, additional, Cunningham, Coleen K., additional, Fast, Patricia E., additional, Fouda, Genevieve G., additional, Freedberg, Kenneth A., additional, Goga, Ameena, additional, Ghazaryan, Lusine R., additional, Leroy, Valériane, additional, Mann, Carlyn, additional, McCluskey, Margaret M., additional, McFarland, Elizabeth J., additional, Muturi-Kioi, Vincent, additional, Permar, Sallie R., additional, Shapiro, Roger, additional, Sok, Devin, additional, Stranix-Chibanda, Lynda, additional, Weinstein, Milton C., additional, Ciaranello, Andrea L., additional, and Dugdale, Caitlin M., additional

Published
2023
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26. The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2

Author

Huang, Ruiqi, primary, Warner Jenkins, Gabrielle, additional, Kim, Yunjeong, additional, Stanfield, Robyn L., additional, Singh, Amrinder, additional, Martinez-Yamout, Maria, additional, Kroon, Gerard J., additional, Torres, Jonathan L., additional, Jackson, Abigail M., additional, Kelley, Abigail, additional, Shaabani, Namir, additional, Zeng, Baisen, additional, Bacica, Michael, additional, Chen, Wen, additional, Warner, Christopher, additional, Radoicic, Jasmina, additional, Joh, Joongho, additional, Dinali Perera, Krishani, additional, Sang, Huldah, additional, Kim, Tae, additional, Yao, Jianxiu, additional, Zhao, Fangzhu, additional, Sok, Devin, additional, Burton, Dennis R., additional, Allen, Jeff, additional, Harriman, William, additional, Mwangi, Waithaka, additional, Chung, Donghoon, additional, Teijaro, John R., additional, Ward, Andrew B., additional, Dyson, H. Jane, additional, Wright, Peter E., additional, Wilson, Ian A., additional, Chang, Kyeong-Ok, additional, McGregor, Duncan, additional, and Smider, Vaughn V., additional

Published
2023
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27. Broadening a SARS-CoV-1–neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

Author

Zhao, Fangzhu, primary, Yuan, Meng, additional, Keating, Celina, additional, Shaabani, Namir, additional, Limbo, Oliver, additional, Joyce, Collin, additional, Woehl, Jordan, additional, Barman, Shawn, additional, Burns, Alison, additional, Tran, Quoc, additional, Zhu, Xueyong, additional, Ricciardi, Michael, additional, Peng, Linghang, additional, Smith, Jessica, additional, Huang, Deli, additional, Briney, Bryan, additional, Sok, Devin, additional, Nemazee, David, additional, Teijaro, John R., additional, Wilson, Ian A., additional, Burton, Dennis R., additional, and Jardine, Joseph G., additional

Published
2023
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29. Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

Author

Pauthner, Matthias, Havenar-Daughton, Colin, Sok, Devin, Nkolola, Joseph P., Bastidas, Raiza, Boopathy, Archana V., Carnathan, Diane G., Chandrashekar, Abishek, Cirelli, Kimberly M., Cottrell, Christopher A., Eroshkin, Alexey M., Guenaga, Javier, Kaushik, Kirti, Kulp, Daniel W., Liu, Jinyan, McCoy, Laura E., Oom, Aaron L., Ozorowski, Gabriel, Post, Kai W., Sharma, Shailendra K., Steichen, Jon M., de Taeye, Steven W., Tokatlian, Talar, Torrents de la Peña, Alba, Butera, Salvatore T., LaBranche, Celia C., Montefiori, David C., Silvestri, Guido, Wilson, Ian A., Irvine, Darrell J., Sanders, Rogier W., Schief, William R., Ward, Andrew B., Wyatt, Richard T., Barouch, Dan H., Crotty, Shane, and Burton, Dennis R.

Published
2017
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30. A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

Author

Lee, Jeong Hyun, Andrabi, Raiees, Su, Ching-Yao, Yasmeen, Anila, Julien, Jean-Philippe, Kong, Leopold, Wu, Nicholas C., McBride, Ryan, Sok, Devin, Pauthner, Matthias, Cottrell, Christopher A., Nieusma, Travis, Blattner, Claudia, Paulson, James C., Klasse, Per Johan, Wilson, Ian A., Burton, Dennis R., and Ward, Andrew B.

Published
2017
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33. Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

Author

Briney, Bryan, Sok, Devin, Jardine, Joseph G., Kulp, Daniel W., Skog, Patrick, Menis, Sergey, Jacak, Ronald, Kalyuzhniy, Oleksandr, de Val, Natalia, Sesterhenn, Fabian, Le, Khoa M., Ramos, Alejandra, Jones, Meaghan, Saye-Francisco, Karen L., Blane, Tanya R., Spencer, Skye, Georgeson, Erik, Hu, Xiaozhen, Ozorowski, Gabriel, Adachi, Yumiko, Kubitz, Michael, Sarkar, Anita, Wilson, Ian A., Ward, Andrew B., Nemazee, David, Burton, Dennis R., and Schief, William R.

Published
2016
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34. Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

Author

Escolano, Amelia, Steichen, Jon M., Dosenovic, Pia, Kulp, Daniel W., Golijanin, Jovana, Sok, Devin, Freund, Natalia T., Gitlin, Alexander D., Oliveira, Thiago, Araki, Tatsuya, Lowe, Sarina, Chen, Spencer T., Heinemann, Jennifer, Yao, Kai-Hui, Georgeson, Erik, Saye-Francisco, Karen L., Gazumyan, Anna, Adachi, Yumiko, Kubitz, Michael, Burton, Dennis R., Schief, William R., and Nussenzweig, Michel C.

Published
2016
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35. A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans

Author

Sok, Devin, Pauthner, Matthias, Briney, Bryan, Lee, Jeong Hyun, Saye-Francisco, Karen L., Hsueh, Jessica, Ramos, Alejandra, Le, Khoa M., Jones, Meaghan, Jardine, Joseph G., Bastidas, Raiza, Sarkar, Anita, Liang, Chi-Hui, Shivatare, Sachin S., Wu, Chung-Yi, Schief, William R., Wong, Chi-Huey, Wilson, Ian A., Ward, Andrew B., Zhu, Jiang, Poignard, Pascal, and Burton, Dennis R.

Published
2016
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36. Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

Author

Sok, Devin, Briney, Bryan, Jardine, Joseph G., Kulp, Daniel W., Menis, Sergey, Pauthner, Matthias, Wood, Andrew, Lee, E-Chiang, Le, Khoa M., Jones, Meaghan, Ramos, Alejandra, Kalyuzhniy, Oleksandr, Adachi, Yumiko, Kuhitz, Michael, MacPherson, Skye, Bradley, Allan, Friedrich, Glenn A., Schief, William R., and Burton, Dennis R.

Published
2016

37. Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

Author

Liu, Jinyan, Ghneim, Khader, Sok, Devin, Bosche, William J., Li, Yuan, Chipriano, Elizabeth, Berkemeier, Brian, Oswald, Kelli, Borducchi, Erica, Cabral, Crystal, Peter, Lauren, Brinkman, Amanda, Shetty, Mayuri, Jimenez, Jessica, Mondesir, Jade, Lee, Benjamin, Giglio, Patricia, Chandrashekar, Abishek, Abbink, Peter, Colantonio, Arnaud, Gittens, Courtney, Baker, Chantelle, Wagner, Wendeline, Lewis, Mark G., Li, Wenjun, Sekaly, Rafick-Pierre, Lifson, Jeffrey D., Burton, Dennis R., and Barouch, Dan H.

Published
2016

38. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

Author

Jardine, Joseph G., Kulp, Daniel W., Havenar-Daughton, Colin, Sarkar, Anita, Briney, Bryan, Sok, Devin, Sesterhenn, Fabian, Ereño-Orbea, June, Kalyuzhniy, Oleksandr, Deresa, Isaiah, Hu, Xiaozhen, Spencer, Skye, Jones, Meaghan, Georgeson, Erik, Adachi, Yumiko, Kubitz, Michael, deCamp, Allan C., Julien, Jean-Philippe, Wilson, Ian A., Burton, Dennis R., Crotty, Shane, and Schief, William R.

Published
2016

39. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

Author

Bornholdt, Zachary A., Turner, Hannah L., Murin, Charles D., Li, Wen, Sok, Devin, Souders, Colby A., Piper, Ashley E., Goff, Arthur, Shamblin, Joshua D., Wollen, Suzanne E., Sprague, Thomas R., Fusco, Marnie L., Pommert, Kathleen B. J., Cavacini, Lisa A., Smith, Heidi L., Klempner, Mark, Reimann, Keith A., Krauland, Eric, Gerngross, Tillman U., Wittrup, Karl D., Saphire, Erica Ollmann, Burton, Dennis R., Glass, Pamela J., Ward, Andrew B., and Walker, Laura M.

Published
2016

40. Ancestral SARS-CoV-2-Driven Antibody Repertoire Diversity in an Unvaccinated Individual Correlates with Expanded Neutralization Breadth

Author

Deshpande, Suprit, primary, Ansari, Mohammed Yousuf, additional, Sutar, Jyoti, additional, Das, Payel, additional, Hingankar, Nitin, additional, Mukherjee, Sohini, additional, Jayal, Priyanka, additional, Singh, Savita, additional, Anantharaj, Anbalagan, additional, Singh, Janmejay, additional, Chattopadhyay, Souvick, additional, Raghavan, Sreevatsan, additional, Gosain, Mudita, additional, Chauhan, Supriya, additional, Shrivas, Shweta, additional, Prasad, Chaman, additional, Chauhan, Sangeeta, additional, Sharma, Neha, additional, Jana, Pradipta, additional, Thiruvengadam, Ramachandran, additional, Kshetrapal, Pallavi, additional, Wadhwa, Nitya, additional, Das, Bhabatosh, additional, Batra, Gaurav, additional, Medigeshi, Guruprasad, additional, Sok, Devin, additional, Bhatnagar, Shinjini, additional, Garg, Pramod Kumar, additional, and Bhattacharya, Jayanta, additional

Published
2023
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41. Efficient isolation of rare B cells using next-generation antigen barcoding

Author

Hurtado, Jonathan, primary, Flynn, Claudia, additional, Lee, Jeong Hyun, additional, Salcedo, Eugenia C., additional, Cottrell, Christopher A., additional, Skog, Patrick D., additional, Burton, Dennis R., additional, Nemazee, David, additional, Schief, William R., additional, Landais, Elise, additional, Sok, Devin, additional, and Briney, Bryan, additional

Published
2023
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42. Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows

Author

Sok, Devin, Le, Khoa M., Vadnais, Melissa, Saye-Francisco, Karen L., Jardine, Joseph G., Torres, Jonathan L., Berndsen, Zachary T., Kong, Leopold, Stanfield, Robyn, Ruiz, Jennifer, Ramos, Alejandra, Liang, Chi-Hui, Chen, Patricia L., Criscitiello, Michael F., Mwangi, Waithaka, Wilson, Ian A., Ward, Andrew B., Smider, Vaughn V., and Burton, Dennis R.

Subjects
Immunogenetics -- Research, Cows (Cattle) -- Genetic aspects, HIV antibodies -- Research, Immunologic research, Animal vaccination -- Methods, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Devin Sok [1, 2, 3, 4]; Khoa M. Le [1, 2, 3, 4]; Melissa Vadnais [5]; Karen L. Saye-Francisco [1, 2, 3]; Joseph G. Jardine [1, 2, 3]; Jonathan [...]

Published
2017
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44. HIV-1 neutralizing antibodies induced by native-like envelope trimers

Author

Sanders, Rogier W., van Gils, Marit J., Derking, Ronald, Sok, Devin, Ketas, Thomas J., Burger, Judith A., Ozorowski, Gabriel, Cupo, Albert, Simonich, Cassandra, Goo, Leslie, Arendt, Heather, Kim, Helen J., Lee, Jeong Hyun, Pugach, Pavel, Williams, Melissa, Debnath, Gargi, Moldt, Brian, van Breemen, Mariëlle J., Isik, Gözde, Medina-Ramírez, Max, Back, Jaap Willem, Koff, Wayne C., Julien, Jean-Philippe, Rakasz, Eva G., Seaman, Michael S., Guttman, Miklos, Lee, Kelly K., Klasse, Per Johan, LaBranche, Celia, Schief, William R., Wilson, Ian A., Overbaugh, Julie, Burton, Dennis R., Ward, Andrew B., Montefiori, David C., Dean, Hansi, and Moore, John P.

Published
2015

45. Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes

Author

Asmal, Mohammed, Luedemann, Corinne, Lavine, Christy L., Mach, Linh V., Balachandran, Harikrishnan, Brinkley, Christie, Denny, Thomas N., Lewis, Mark G., Anderson, Hanne, Pal, Ranajit, Sok, Devin, Le, Khoa, Pauthner, Matthias, Hahn, Beatrice H., Shaw, George M., Seaman, Michael S., Letvin, Norman L., Burton, Dennis R., Sodroski, Joseph G., Haynes, Barton F., and Santra, Sampa

Published
2015
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46. Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer

Author

van Schooten, Jelle, primary, Schorcht, Anna, additional, Farokhi, Elinaz, additional, Umotoy, Jeffrey C., additional, Gao, Hongmei, additional, van den Kerkhof, Tom L. G. M., additional, Dorning, Jessica, additional, Rijkhold Meesters, Tim G., additional, van der Woude, Patricia, additional, Burger, Judith A., additional, Bijl, Tom, additional, Ghalaiyini, Riham, additional, Torrents de la Peña, Alba, additional, Turner, Hannah L., additional, Labranche, Celia C., additional, Stanfield, Robyn L., additional, Sok, Devin, additional, Schuitemaker, Hanneke, additional, Montefiori, David C., additional, Burton, Dennis R., additional, Ozorowski, Gabriel, additional, Seaman, Michael S., additional, Wilson, Ian A., additional, Sanders, Rogier W., additional, Ward, Andrew B., additional, and van Gils, Marit J., additional

Published
2022
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47. Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice

Author

Melzi, Eleonora, primary, Willis, Jordan R., additional, Ma, Krystal M., additional, Lin, Ying-Cing, additional, Kratochvil, Sven, additional, Berndsen, Zachary T., additional, Landais, Elise A., additional, Kalyuzhniy, Oleksandr, additional, Nair, Usha, additional, Warner, John, additional, Steichen, Jon M., additional, Kalyuzhniy, Anton, additional, Le, Amber, additional, Pecetta, Simone, additional, Perez, Manfredo, additional, Kirsch, Kathrin, additional, Weldon, Stephanie R., additional, Falcone, Samantha, additional, Himansu, Sunny, additional, Carfi, Andrea, additional, Sok, Devin, additional, Ward, Andrew B., additional, Schief, William R., additional, and Batista, Facundo D., additional

Published
2022
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49. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques

Author

Magnani, Diogo M., Rogers, Thomas F., Beutler, Nathan, Ricciardi, Michael J., Bailey, Varian K., Gonzalez-Nieto, Lucas, Briney, Bryan, Sok, Devin, Le, Khoa, Strubel, Alexander, Gutman, Martin J., Pedreño-Lopez, Núria, Grubaugh, Nathan D., Silveira, Cassia G. T., Maxwell, Helen S., Domingues, Aline, Martins, Mauricio A., Lee, David E., Okwuazi, Erica E., Jean, Sherrie, Strobert, Elizabeth A., Chahroudi, Ann, Silvestri, Guido, Vanderford, Thomas H., Kallas, Esper G., Desrosiers, Ronald C., Bonaldo, Myrna C., Whitehead, Stephen S., Burton, Dennis R., and Watkins, David I.

Published
2017
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50. Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

Author

Julg, Boris, Tartaglia, Lawrence J., Keele, Brandon F., Wagh, Kshitij, Pegu, Amarendra, Sok, Devin, Abbink, Peter, Schmidt, Stephen D., Wang, Keyun, Chen, Xuejun, Gordon Joyce, M., Georgiev, Ivelin S., Choe, Misook, Kwong, Peter D., Doria-Rose, Nicole A., Le, Khoa, Louder, Mark K., Bailer, Robert T., Moore, Penny L., Korber, Bette, Seaman, Michael S., Abdool Karim, Salim S., Morris, Lynn, Koup, Richard A., Mascola, John R., Burton, Dennis R., and Barouch, Dan H.

Published
2017
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