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3 results on '"Soigner, Yvette"'

1. Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C)

Author

Dick, Jenna K, Sangala, Jules A, Krishna, Venkatramana D, Khaimraj, Aaron, Hamel, Lydia, Erickson, Spencer M, Hicks, Dustin, Soigner, Yvette, Covill, Laura E, Johnson, Alexander K, Ehrhardt, Michael J, Ernste, Keenan, Brodin, Petter, Koup, Richard A, Khaitan, Alka, Baehr, Carly, Thielen, Beth K, Henzler, Christine M, Skipper, Caleb, Miller, Jeffrey S, Bryceson, Yenan T, Wu, Jianming, John, Chandy C, Panoskaltsis-Mortari, Angela, Orioles, Alberto, Steiner, Marie E, Cheeran, Maxim C-J, Pravetoni, Marco, and Hart, Geoffrey T

Published
2024
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2. NK Cell and Monocyte Dysfunction in Multisystem Inflammatory Syndrome in Children.

Author

Dick JK, Sangala JA, Krishna VD, Khaimraj A, Hamel L, Erickson SM, Hicks D, Soigner Y, Covill LE, Johnson AK, Ehrhardt MJ, Ernste K, Brodin P, Koup RA, Khaitan A, Baehr C, Thielen BK, Henzler CM, Skipper C, Miller JS, Bryceson YT, Wu J, John CC, Panoskaltsis-Mortari A, Orioles A, Steiner ME, Cheeran MCJ, Pravetoni M, and Hart GT

Subjects
Humans, Child, Male, Female, Child, Preschool, Adolescent, Infant, Phagocytosis immunology, Receptors, IgG immunology, Interleukin-6 immunology, Cytokines immunology, Cytokines metabolism, Killer Cells, Natural immunology, COVID-19 immunology, COVID-19 complications, Systemic Inflammatory Response Syndrome immunology, Monocytes immunology, SARS-CoV-2 immunology
Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infection characterized by multiorgan involvement and inflammation. Testing of cellular function ex vivo to understand the aberrant immune response in MIS-C is limited. Despite strong Ab production in MIS-C, SARS-CoV-2 nucleic acid testing can remain positive for 4-6 wk postinfection. Therefore, we hypothesized that dysfunctional cell-mediated Ab responses downstream of Ab production may be responsible for delayed clearance of viral products in MIS-C. In MIS-C, monocytes were hyperfunctional for phagocytosis and cytokine production, whereas NK cells were hypofunctional for both killing and cytokine production. The decreased NK cell cytotoxicity correlated with an NK exhaustion marker signature and systemic IL-6 levels. Potentially providing a therapeutic option, cellular engagers of CD16 and SARS-CoV-2 proteins were found to rescue NK cell function in vitro. Taken together, our results reveal dysregulation in Ab-mediated cellular responses of myeloid and NK cells that likely contribute to the immune pathology of this disease., (Copyright © 2024 by The American Association of Immunologists, Inc.)

Published
2024
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3. Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C).

Author

Dick JK, Sangala JA, Krishna VD, Khaimraj A, Hamel L, Erickson SM, Hicks D, Soigner Y, Covill LE, Johnson A, Ehrhardt MJ, Ernste K, Brodin P, Koup RA, Khaitan A, Baehr C, Thielen BK, Henzler CM, Skipper C, Miller JS, Bryceson YT, Wu J, John CC, Panoskaltsis-Mortari A, Orioles A, Steiner ME, Cheeran MC, Pravetoni M, and Hart GT

Abstract

Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe complication of SARS-CoV-2 infection characterized by multi-organ involvement and inflammation. Testing of cellular function ex vivo to understand the aberrant immune response in MIS-C is limited. Despite strong antibody production in MIS-C, SARS-CoV-2 nucleic acid testing can remain positive for 4-6 weeks after infection. Therefore, we hypothesized that dysfunctional cell-mediated antibody responses downstream of antibody production may be responsible for delayed clearance of viral products in MIS-C. In MIS-C, monocytes were hyperfunctional for phagocytosis and cytokine production, while natural killer (NK) cells were hypofunctional for both killing and cytokine production. The decreased NK cell cytotoxicity correlated with an NK exhaustion marker signature and systemic IL-6 levels. Potentially providing a therapeutic option, cellular engagers of CD16 and SARS-CoV-2 proteins were found to rescue NK cell function in vitro. Together, our results reveal dysregulation in antibody-mediated cellular responses unique to MIS-C that likely contribute to the immune pathology of this disease.

Published
2024
Full Text
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