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3. Sex-specific outcomes and left atrial remodeling following catheter ablation of persistent atrial fibrillation: results from the DECAAF II trial

Author

Younes, Hadi, Sohns, Christian, Akoum, Nazem, Feng, Han, Tsakiris, Eli, Hajjar, Abdel Hadi El, Donnellan, Eoin, Pandey, Amitabh C., Lim, Chanho, Bidaoui, Ghassan, Mekhael, Mario, Noujeim, Charbel, Chouman, Nour, Assaf, Ala, Shamaileh, Ghaith, Polo, Francisco Tirado, Bsoul, Mayana, Dagher, Lilas, Kreidieh, Omar, Rao, Swati, Sommer, Philipp, Forkmann, Mathias, Brachmann, Johannes, Marrouche, Nassir, and Mahnkopf, Christian

Published
2024
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9. Prognosis of patients in end-stage heart failure with atrial fibrillation treated with ablation: Insights from CASTLE-HTx

Author

Moersdorf, Maximilian, Tijssen, Jan G.P., Marrouche, Nassir F., Crijns, Harry J.G.M., Costard-Jaeckle, Angelika, Bergau, Leonard, Hindricks, Gerhard, Dagres, Nikolaos, Sossalla, Samuel, Schramm, Rene, Fox, Henrik, Fink, Thomas, El Hamriti, Mustapha, Sciacca, Vanessa, Konietschke, Frank, Rudolph, Volker, Gummert, Jan, Sommer, Philipp, and Sohns, Christian

Published
2024
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11. Clinical Characterization of Arrhythmia-Induced Cardiomyopathy in Patients With Tachyarrhythmia and Idiopathic Heart Failure

Author

Schach, Christian, Körtl, Thomas, Zeman, Florian, Luttenberger, Bianca, Mühleck, Franziska, Baum, Paul, Lavall, Daniel, Vosshage, Nicola H., Resch, Markus, Ripfel, Sarah, Meindl, Christine, Ücer, Ekrem, Hamer, Okka W., Baessler, Andrea, Arzt, Michael, Koller, Michael, Sohns, Christian, Maier, Lars S., Wachter, Rolf, and Sossalla, Samuel

Published
2024
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12. Unipolar voltage electroanatomic mapping detects structural atrial remodeling identified by LGE-MRI

Author

Ali, Syed Yusuf, Mohsen, Yazan, Mao, Yuncong, Sakata, Kensuke, Kholmovski, Eugene G., Prakosa, Adityo, Yamamoto, Carolyna, Loeffler, Shane, Elia, Marianna, Zandieh, Ghazal, Stöckigt, Florian, Horlitz, Marc, Sinha, Sunil Kumar, Marine, Joseph, Calkins, Hugh, Sommer, Philipp, Sciacca, Vanessa, Fink, Thomas, Sohns, Christian, Spragg, David, and Trayanova, Natalia

Published
2024
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13. Lesion delivery and scar formation in catheter ablation for atrial fibrillation: The DECAAF II trial

Author

Akoum, Nazem, Mekhael, Mario, Bisbal, Felipe, Wazni, Oussama, McGann, Christopher, Lee, Hyejung, Bardsley, Tyler, Greene, Tom, Dean, J. Michael, Dagher, Lilas, Kholmovski, Eugene, Mansour, Moussa, Marchlinski, Francis, Wilber, David, Hindricks, Gerhard, Mahnkopf, Christian, Wells, Darryl, Jaïs, Pierre, Sanders, Prashanthan, Brachmann, Johannes, Bax, Jeroen J., Morrison-de Boer, Leonie, Deneke, Thomas, Calkins, Hugh, Sohns, Christian, and Marrouche, Nassir

Published
2024
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17. Pulsed-field ablation-based pulmonary vein isolation: acute safety, efficacy and short-term follow-up in a multi-center real world scenario

Author

Lemoine, Marc D., Fink, Thomas, Mencke, Celine, Schleberger, Ruben, My, Ilaria, Obergassel, Julius, Bergau, Leonard, Sciacca, Vanessa, Rottner, Laura, Moser, Julia, Kany, Shinwan, Moser, Fabian, Münkler, Paula, Dinshaw, Leon, Kirchhof, Paulus, Reissmann, Bruno, Ouyang, Feifan, Sommer, Philipp, Sohns, Christian, Rillig, Andreas, and Metzner, Andreas

Published
2022
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20. Abstract 12367: Sex-Specific Differences in Quality of Life and Atrial Fibrillation Recurrence Following Ablation of Persistent Atrial Fibrillation: Insights From the DECAAF II Trial

Author

Younes, Hadi, Feng, Han, Sohns, Christian, Forkmann, Mathias, Noujaim, Charbel, Mekhael, Mario, Assaf, Alaʼ, Chouman, Nour, Kreidieh, Omar, huang, chao, Lim, Chanho, El Hajjar, Abdel Hadi, donnellan, eoin, Pandey, Amitabh C, Marrouche, Nassir, and mahnkopf, christian

Published
2023
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21. Abstract 12357: Investigating Sex-Specific Factors Influencing Atrial Fibrillation Burden in Patients With Persistent Atrial Fibrillation: A DECAAF II Subanalysis

Author

Younes, Hadi, Feng, Han, Sohns, Christian, Forkmann, Mathias, Mekhael, Mario, Noujaim, Charbel, Chouman, Nour, Assaf, Alaʼ, Lim, Chanho, Dagher, Lilas, huang, chao, El Hajjar, Abdel Hadi, donnellan, eoin, Kreidieh, Omar, Pandey, Amitabh C, Marrouche, Nassir, and mahnkopf, christian

Published
2023
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27. Preventive catheter ablation for ventricular arrhythmias in patients with end‐stage heart failure referred for heart transplantation evaluation: Rationale for and design of the CASTLE‐VT trial.

Author

Sohns, Christian, Fink, Thomas, Crijns, Harry J.G.M., Costard‐Jaeckle, Angelika, Marrouche, Nassir F., Sossalla, Samuel, Schramm, Rene, El Hamriti, Mustapha, Moersdorf, Maximilian, Didenko, Maxim, Braun, Martin, Sciacca, Vanessa, Konietschke, Frank, Rudolph, Volker, Gummert, Jan, Tijssen, Jan G.P., and Sommer, Philipp

Subjects
*CARDIAC arrest, *CATHETER ablation, *VENTRICULAR arrhythmia, *VENTRICULAR fibrillation, *HEART failure, *IMPLANTABLE cardioverter-defibrillators, *HEART assist devices
Abstract

Aims Methods Conclusion Timely referrals for transplantation and left ventricular assist device (LVAD) play a key role in favourable outcomes in patients with advanced heart failure (HF). Cardiovascular mortality, driven by sudden cardiac death, is the main reason for dying while waiting for heart transplantation (HTx). The purpose of the Preventive Catheter Ablation for ventricular arrhythmiaS in patients with end‐sTage heart faiLure rEferred for heart transplantation eValuaTion (CASTLE‐VT) trial is to test the hypothesis that prophylactic catheter ablation of arrhythmogenic ventricular scar tissue will reduce mortality, need for LVAD implantation, and urgent HTx in patients with end‐stage HF related to ischaemic cardiomyopathy (ICM).CASTLE‐VT is a randomized evaluation of prophylactic ablative treatment of arrhythmogenic ventricular scar in patients referred for HTx evaluation and diagnosed with ICM. Ablation will be performed with the use of a substrate‐based approach in which the myocardial scar is mapped and ablated while the heart remains predominantly in sinus rhythm. The primary endpoint is the composite of all‐cause mortality, worsening of HF requiring prioritized transplantation or LVAD implantation. The main secondary study endpoints are all‐cause mortality, cardiovascular mortality, incidence of implantable cardioverter‐defibrillator (ICD) therapy, hospitalizations, quality of life, time to first ICD therapy, number of device‐detected ventricular tachycardia/ventricular fibrillation episodes, left ventricular function, and exercise tolerance. CASTLE‐VT will randomize 160 patients with a follow‐up period of 2 years.CASTLE‐VT will determine whether prophylactic catheter ablation of arrhythmogenic ventricular scar tissue reduces mortality in patients with end‐stage HF who are referred for HTx evaluation. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Effects of atrial fibrillation ablation on arrhythmia burden and ventricular function in end‐stage heart failure: Lessons from CASTLE‐HTx.

Author

Sciacca, Vanessa, Sohns, Christian, Crijns, Harry J.G.M., Marrouche, Nassir F., Schramm, Rene, Moersdorf, Maximilian, Fink, Thomas, Bergau, Leonard, Hindricks, Gerhard, Dagres, Nikolaos, Sossalla, Samuel, Costard‐Jaeckle, Angelika, Fox, Henrik, El Hamriti, Mustapha, Konietschke, Frank, Rudolph, Volker, Gummert, Jan, Tijssen, Jan G.P., and Sommer, Philipp

Subjects
*ABLATION techniques, *HEART assist devices, *CATHETER ablation, *LEFT heart atrium, *HEART failure patients, *ATRIAL fibrillation
Abstract

Aims Methods and results Conclusion The CASTLE‐HTx trial showed the benefit of atrial fibrillation (AF) ablation compared to medical therapy in decreasing mortality, need for left ventricular assist device implantation or heart transplantation (HTx) in patients with end‐stage heart failure (HF). Herein we describe the effects of catheter ablation on AF burden, arrhythmia recurrences, and ventricular function in end‐stage HF.The CASTLE‐HTx protocol randomized 194 patients in end‐stage HF with AF to catheter ablation and medical therapy or medical therapy alone. AF burden, left ventricular ejection fraction (LVEF), and type of AF were assessed at baseline and at each follow‐up visit. Overall, 97 patients received ablation; 66 patients (68%) underwent pulmonary vein isolation (PVI) and 31 patients (32%) were treated with PVI and additional ablation. Electroanatomic mapping showed the extent of left atrial low voltage (cardiomyopathy) >10% in 31 (31.9%) patients. At 12 months post‐ablation, persistent AF was present in 31/89 patients (34.8%), which was significantly less frequent compared to baseline (p = 0.0001). Median AF burden reduction was 36.3 (interquartile range 13.6–63.3) percentage points at 12 months and LVEF improved from 29.2 ± 6.2% to 39.1 ± 8.3% (p < 0.001) following ablation. AF burden reduction <50% was significantly associated with LVEF improvement ≥5% at 12 months after ablation (p = 0.017).Atrial fibrillation ablation in end‐stage HF leads to a substantial decrease in AF burden, a regression from persistent to paroxysmal AF and notably improved LVEF. Favourable ablation outcomes were observed in patients regardless of the presence or absence of signs indicating left atrial cardiomyopathy. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Mitral valve prolapse: arrhythmic risk during pregnancy and postpartum

Author

Sabbag, Avi, primary, Aabel, Eivind W, additional, Castrini, Anna Isotta, additional, Siontis, Konstantinos C, additional, Laredo, Mikael, additional, Nizard, Jacky, additional, Duthoit, Guillaume, additional, Asirvatham, Samuel, additional, Sehrawat, Ojasay, additional, Kirkels, Feddo P, additional, van Rosendael, Philippe J, additional, Beinart, Roy, additional, Acha, Moshe Rav, additional, Peichl, Petr, additional, Lim, Han S, additional, Sohns, Christian, additional, Martins, Raphael, additional, Font, Jonaz, additional, Truong, Nguyen N K, additional, Estensen, Mette, additional, and Haugaa, Kristina H, additional

Published
2024
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30. Ablation STrategies for Repeat PrOcedures in Atrial Fibrillation Recurrences despite Durable Pulmonary Vein Isolation. ASTRO - AF Trial

Author

Schmidt, Boris, primary, Bordignon, Stefano, additional, Metzner, Andreas, additional, Sommer, Philipp, additional, Steven, Daniel, additional, Dahme, Tilmann, additional, Busch, Matthias, additional, Tilz, Roland Richard, additional, Schaack, David, additional, Rillig, Andreas, additional, Sohns, Christian, additional, Sultan, Arian, additional, Weinmann-Emhardt, Karolina, additional, Hummel, Astrid, additional, Vogler, Julia, additional, Fink, Thomas, additional, Lueker, Jakob, additional, Pott, Alexander, additional, Heeger, Christian, additional, and Julian Chun, KR, additional

Published
2024
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32. Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference

Author

Linz, Dominik, primary, Andrade, Jason G, additional, Arbelo, Elena, additional, Boriani, Giuseppe, additional, Breithardt, Guenter, additional, Camm, A John, additional, Caso, Valeria, additional, Nielsen, Jens Cosedis, additional, De Melis, Mirko, additional, De Potter, Tom, additional, Dichtl, Wolfgang, additional, Diederichsen, Søren Zoega, additional, Dobrev, Dobromir, additional, Doll, Nicolas, additional, Duncker, David, additional, Dworatzek, Elke, additional, Eckardt, Lars, additional, Eisert, Christoph, additional, Fabritz, Larissa, additional, Farkowski, Michal, additional, Filgueiras-Rama, David, additional, Goette, Andreas, additional, Guasch, Eduard, additional, Hack, Guido, additional, Hatem, Stéphane, additional, Haeusler, Karl Georg, additional, Healey, Jeff S, additional, Heidbuechel, Hein, additional, Hijazi, Ziad, additional, Hofmeister, Lucas H, additional, Hove-Madsen, Leif, additional, Huebner, Thomas, additional, Kääb, Stefan, additional, Kotecha, Dipak, additional, Malaczynska-Rajpold, Katarzyna, additional, Merino, José Luis, additional, Metzner, Andreas, additional, Mont, Lluís, additional, Ng, Ghulam Andre, additional, Oeff, Michael, additional, Parwani, Abdul Shokor, additional, Puererfellner, Helmut, additional, Ravens, Ursula, additional, Rienstra, Michiel, additional, Sanders, Prashanthan, additional, Scherr, Daniel, additional, Schnabel, Renate, additional, Schotten, Ulrich, additional, Sohns, Christian, additional, Steinbeck, Gerhard, additional, Steven, Daniel, additional, Toennis, Tobias, additional, Tzeis, Stylianos, additional, van Gelder, Isabelle C, additional, van Leerdam, Roderick H, additional, Vernooy, Kevin, additional, Wadhwa, Manish, additional, Wakili, Reza, additional, Willems, Stephan, additional, Witt, Henning, additional, Zeemering, Stef, additional, and Kirchhof, Paulus, additional

Published
2024
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35. Mitral valve prolapse: arrhythmic risk during pregnancy and postpartum

Author

Team Onderzoek, Cardiologie, Team Medisch, Sabbag, Avi, Aabel, Eivind W., Castrini, Anna Isotta, Siontis, Konstantinos C., Laredo, Mikael, Nizard, Jacky, Duthoit, Guillaume, Asirvatham, Samuel, Sehrawat, Ojasay, Kirkels, Feddo P., van Rosendael, Philippe J., Beinart, Roy, Acha, Moshe Rav, Peichl, Petr, Lim, Han S., Sohns, Christian, Martins, Raphael, Font, Jonaz, Truong, Nguyen N.K., Estensen, Mette, Haugaa, Kristina H., Team Onderzoek, Cardiologie, Team Medisch, Sabbag, Avi, Aabel, Eivind W., Castrini, Anna Isotta, Siontis, Konstantinos C., Laredo, Mikael, Nizard, Jacky, Duthoit, Guillaume, Asirvatham, Samuel, Sehrawat, Ojasay, Kirkels, Feddo P., van Rosendael, Philippe J., Beinart, Roy, Acha, Moshe Rav, Peichl, Petr, Lim, Han S., Sohns, Christian, Martins, Raphael, Font, Jonaz, Truong, Nguyen N.K., Estensen, Mette, and Haugaa, Kristina H.

Published
2024

36. Longer and better lives for patients with atrial fibrillation : the 9th AFNET/EHRA consensus conference

Author

Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, Kirchhof, Paulus, Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, and Kirchhof, Paulus

Abstract

Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in Munster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF. Graphical Abstract

Published
2024
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37. Longer and better lives for patients with atrial fibrillation:the 9th AFNET/EHRA consensus conference

Author

Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stéphane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, José Luis, Metzner, Andreas, Mont, Lluís, Andre Ng, Ghulam, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, Kirchho, Paulus, Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stéphane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, José Luis, Metzner, Andreas, Mont, Lluís, Andre Ng, Ghulam, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, and Kirchho, Paulus

Abstract

Aims Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA) Methods Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm and results management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF.Conclusions Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF.

Published
2024

40. Atrial fibrillation ablation in heart failure patients: Where do we stand in 2023? – State of the art review

Author

Deering, Thomas F., primary, Goyal, Sandeep K., additional, Bhimani, Ashish A., additional, Hoosien, Michael, additional, Karimianpour, Ahmadreza, additional, Krishnasamy, Kavita P., additional, Nilsson, Kent R., additional, Omar, Abdullah, additional, Lakkireddy, Dhanunjaya, additional, Gopinathannair, Rakesh, additional, Katapadi, Aashish, additional, and Sohns, Christian, additional

Published
2023
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47. Phrenic Nerve Injury During Cryoballoon-Based Pulmonary Vein Isolation: Results of the Worldwide YETI Registry

Author

Heeger, Christian-H., Sohns, Christian, Pott, Alexander, Metzner, Andreas, Inaba, Osamu, Straube, Florian, Kuniss, Malte, Aryana, Arash, Miyazaki, Shinsuke, Cay, Serkan, Ehrlich, Joachim R., El-Battrawy, Ibrahim, Martinek, Martin, Saguner, Ardan M., Tscholl, Verena, Yalin, Kivanc, Lyan, Evgeny, Su, Wilber, Papiashvili, Giorgi, Botros, Maichel Sobhy Naguib, Gasperetti, Alessio, Proietti, Riccardo, Wissner, Erik, Scherr, Daniel, Kamioka, Masashi, Makimoto, Hisaki, Urushida, Tsuyoshi, Aksu, Tolga, Chun, Julian K.R., Aytemir, Kudret, Jędrzejczyk-Patej, Ewa, Kuck, Karl-Heinz, Dahme, Tillman, Steven, Daniel, Sommer, Philipp, and Richard Tilz, Roland

Published
2022
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48. Second-Generation Cryoballoon Atrial Fibrillation Ablation in Patients With Persistent Left Superior Caval Vein

Author

Santoro, Francesco, Rillig, Andreas, Sohns, Christian, Pott, Alexander, Brunetti, Natale Daniele, Reissmann, Bruno, Lemeš, Christine, Maurer, Tilman, Fink, Thomas, Hashiguchi, Naotaka, Sano, Makoto, Mathew, Shibu, Dahme, Tillman, Ouyang, Feifan, Kuck, Karl-Heinz, Tilz, Roland Richard, Metzner, Andreas, and Heeger, Christian-Hendrik

Published
2019
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50. Atrial fibrillation ablation workflow optimization facilitated by high-power short-duration ablation and high-resolution mapping.

Author

Fink, Thomas, Sciacca, Vanessa, Nischik, Flemming, Bergau, Leonard, Guckel, Denise, Hamriti, Mustapha El, Khalaph, Moneeb, Braun, Martin, Winnik, Stephan, Didenko, Maxim, Imnadze, Guram, Sommer, Philipp, and Sohns, Christian

Abstract

Aims Pulmonary vein isolation (PVI) for catheter ablation of atrial fibrillation (AF) is a time-demanding procedure. High-power short-duration (HPSD) ablation protocols and high-density mapping catheters have recently been introduced to clinical practice. We investigated the impact of high-density mapping and HPSD ablation protocols on procedural timing, efficacy, and safety by comparing different standardized set-ups. Methods and results Three electrophysiology (EP) laboratory set-ups were analysed: (i) circular catheter for mapping and HPSD ablation with 30/35 W guided by an ablation index (AI); (ii) pentaspline catheter for mapping an HPSD ablation with 50 W guided by an AI; and (iii) pentaspline catheter for mapping and HPSD ablation with 90 W over 4 s using a novel ablation catheter. All patients underwent PVI without additional left atrial ablation strategies. Procedural data and operating intervals in the EP laboratory were systematically analysed. Three hundred seven patients were analysed (30/35 W AI: n = 102, 50 W AI: n = 102, 90 W/4 s: n = 103). Skin-to-skin times [105.3 ± 22.7 (30/35 W AI) vs. 81.4 ± 21.3 (50 W AI) vs. 69.5 ± 12.2 (90 W/4 s) min, P ≤ 0.001] and total laboratory times (132.8 ± 42.1 vs. 107.4 ± 25.7 vs. 95.2 ± 14.0 min, P < 0.001) significantly differed among the study groups. Laboratory interval analysis revealed significant shortening of mapping and ablation times. Arrhythmia-free survival after 12 months was not different among the study groups (log-rank P = 0.96). Conclusion The integration of high-density mapping and HPSD protocols into an institutional AF ablation process resulted in reduced procedure times without compromising safety or efficacy. [ABSTRACT FROM AUTHOR]

Published
2024
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