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7. Continuous versus intermittent infusion of human antithrombin III concentrate in the immediate postoperative period after liver transplantation

Author

Kim, Bo Rim, primary, Lim, Leerang, additional, Choi, YoungRok, additional, Yi, Nam‐Joon, additional, Lee, Kwang‐Woong, additional, Suh, Kyung‐Suk, additional, Yu, Kyung‐Sang, additional, Sohn, Jin Young, additional, Jeong, Raewon, additional, Oh, Jaeseong, additional, and Ryu, Ho Geol, additional

Published
2023
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14. Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility

Author

Sung, Hui-Jin, primary, Ok, Seong-Ho, additional, Sohn, Jin-Young, additional, Son, Yong Hyeok, additional, Kim, Jun Kyu, additional, Lee, Soo Hee, additional, Han, Jeong Yeol, additional, Lim, Dong Hoon, additional, Shin, Il-Woo, additional, Lee, Heon-Keun, additional, Chung, Young-Kyun, additional, Choi, Mun-Jeoung, additional, and Sohn, Ju-Tae, additional

Published
2012
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17. Survivin inhibits anti-growth effect of p53 activated by aurora B

Author

Jung, Ji-Eun, primary, Kim, Tae-Kyung, additional, Lee, Joong-Seob, additional, Oh, Se-Yeong, additional, Kwak, Sungwook, additional, Jin, Xun, additional, Sohn, Jin-Young, additional, Song, Min-Keun, additional, Sohn, Young-Woo, additional, Lee, Soo-Yeon, additional, Pian, Xumin, additional, Lee, Jang-Bo, additional, Chung, Yong Gu, additional, Choi, Young Ki, additional, You, Seungkwon, additional, and Kim, Hyunggee, additional

Published
2005
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19. Vasoconstriction Potency Induced by Aminoamide Local Anesthetics Correlates with Lipid Solubility

Author

Sung, Hui-Jin, Ok, Seong-Ho, Sohn, Jin-Young, Hyeok Son, Yong, Kyu Kim, Jun, Hee Lee, Soo, Yeol Han, Jeong, Hoon Lim, Dong, Shin, Il-Woo, Lee, Heon-Keun, Chung, Young-Kyun, Choi, Mun-Jeoung, and Sohn, Ju-Tae

Abstract

Aminoamide local anesthetics induce vasoconstriction in vivo and in vitro. The goals of this in vitro study were to investigate the potency of local anesthetic-induced vasoconstriction and to identify the physicochemical property (octanol/buffer partition coefficient, pKa, molecular weight, or potency) of local anesthetics that determines their potency in inducing isolated rat aortic ring contraction. Cumulative concentration-response curves to local anesthetics (levobupivacaine, ropivacaine, lidocaine, and mepivacaine) were obtained from isolated rat aorta. Regression analyses were performed to determine the relationship between the reported physicochemical properties of local anesthetics and the local anesthetic concentration that produced 50% (ED50) of the local anesthetic-induced maximum vasoconstriction. We determined the order of potency (ED50) of vasoconstriction among local anesthetics to be levobupivacaine > ropivacaine > lidocaine > mepivacaine. The relative importance of the independent variables that affect the vasoconstriction potency is octanol/buffer partition coefficient > potency > pKa > molecular weight. The ED50 in endothelium-denuded aorta negatively correlated with the octanol/buffer partition coefficient of local anesthetics (r2=0.9563; P<0.001). The potency of the vasoconstriction in the endothelium-denuded aorta induced by local anesthetics is determined primarily by lipid solubility and, in part, by other physicochemical properties including potency and pKa.

Published
2012
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20. Comparison of two different preload targets of stroke volume variation during kidney transplantation: a randomised controlled trial.

Author

Yang SM, Song SE, Jung JY, Ju JW, Sohn JY, Lee HJ, and Kim WH

Abstract

Introduction: Maintaining adequate preload during kidney transplantation (KT) is important for graft function. We evaluated whether a high or low normal target for a dynamic preload index of stroke volume variation (SVV) would impact graft function during living donor KT., Methods: We compared haemodynamic management algorithms using two different targets of SVV: SVV6% group (n = 30) versus SVV12% group (n = 30). Crystalloids were administered to achieve SVV less than the assigned target. Neutrophil gelatinase-associated lipocalin (NGAL) level at the end of surgery was compared. We also compared the incidence of delayed graft function (DGF), daily serum creatinine level and glomerular filtration rate (GFR) until 2 weeks postoperatively., Results: The total amount of crystalloids administered was significantly different between the SVV6% and SVV12% groups (median [interquartile range] 2,250 [1,700-3,600] vs. 1,350 [1,050-1,900], P < 0.001). There was no significant difference in NGAL level at the end of the operation between the SVV6% and SVV12% groups (395 [234-560] vs. 518 [346-654], P = 0.115). The incidence of DGF was not significantly different, and there was no significant difference in the postoperative serum creatinine levels or GFR between the groups., Conclusions: Our randomised trial demonstrated that an SVV target of either 6% or 12% could be adequate as a preload management target for postoperative graft function during living donor KT. However, given the low incidence of DGF in living donor KT and type II error, our study should be interpreted carefully and further studies for deceased donor KT are required., (Copyright © 2024 Copyright: © 2024 Singapore Medical Journal.)

Published
2024
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