42 results on '"Sohl E"'
Search Results
2. Serum insulin-like growth factor 1 and late-life depression: A population-based study
- Author
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van Varsseveld, N.C., van Bunderen, C.C., Sohl, E., Comijs, H.C., Penninx, B.W.J.H., Lips, P., and Drent, M.L.
- Published
- 2015
- Full Text
- View/download PDF
3. Low vitamin D status is associated with more depressive symptoms in Dutch older adults
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Brouwer-Brolsma, E. M., Dhonukshe-Rutten, R. A. M., van Wijngaarden, J. P., van der Zwaluw, N. L., Sohl, E., In’t Veld, P. H., van Dijk, S. C., Swart, K. M. A., Enneman, A. W., Ham, A. C., van Schoor, N. M., van der Velde, N., Uitterlinden, A. G., Lips, P., Feskens, E. J. M., and de Groot, L. C. P. G. M.
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- 2016
- Full Text
- View/download PDF
4. BMI and body fat mass is inversely associated with vitamin D levels in older individuals
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Oliai Araghi, S., van Dijk, S. C., Ham, A. C., Brouwer-Brolsma, E. M., Enneman, A. W., Sohl, E., Swart, K. M. A., van der Zwaluw, N. L., van Wijngaarden, J. P., Dhonukshe-Rutten, R. A. M., van Schoor, N. M., Zillikens, M. C., Lips, P., de Groot, L., Uitterlinden, A. G., and van der Velde, Nathalie
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- 2015
- Full Text
- View/download PDF
5. The Association Between Vitamin D Status and Parameters for Bone Density and Quality is Modified by Body Mass Index
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Sohl, E., de Jongh, R. T., Swart, K. M. A., Enneman, A. W., van Wijngaarden, J. P., van Dijk, S. C., Ham, A. C., van der Zwaluw, N. L., Brouwer-Brolsma, E. M., van der Velde, N., de Groot, C. P. G. M., te Velde, S. J., Lips, P., and van Schoor, N. M.
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- 2015
- Full Text
- View/download PDF
6. Gender-Specific Associations of Serum Insulin-Like Growth Factor-1 With Bone Health and Fractures in Older Persons
- Author
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van Varsseveld, N. C., Sohl, E., Drent, M. L., and Lips, P.
- Published
- 2015
7. Thresholds for Serum 25(OH)D Concentrations With Respect to Different Outcomes
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Sohl, E., de Jongh, R. T., Heymans, M. W., van Schoor, N. M., and Lips, P.
- Published
- 2015
8. Vitamin D status is associated with physical performance: the results of three independent cohorts
- Author
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Sohl, E., de Jongh, R. T., Heijboer, A. C., Swart, K. M. A., Brouwer-Brolsma, E. M., Enneman, A. W., de Groot, C. P. G. M., van der Velde, N., Dhonukshe-Rutten, R. A. M., Lips, P., and van Schoor, N. M.
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- 2013
- Full Text
- View/download PDF
9. Vitamin D Status Is Associated With Functional Limitations and Functional Decline in Older Individuals
- Author
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Sohl, E., van Schoor, N. M., de Jongh, R. T., Visser, M., Deeg, D. J. H., and Lips, P.
- Published
- 2013
10. Histomorphometric Analysis Reveals Reduced Bone Mass and Bone Formation in Patients With Quiescent Crohn's Disease
- Author
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Oostlander, A.E., Bravenboer, N., Sohl, E., Holzmann, P.J., Woude, C.J. van der, Dijkstra, G., Stokkers, P.C.F., Oldenburg, B., Netelenbos, J.C., Hommes, D.W., Bodegraven, A.A. van, Lips, P., Dutch Initiative Crohn Colitis ICC, Research Institute MOVE, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Groningen Institute for Organ Transplantation (GIOT), Internal medicine, Clinical chemistry, Epidemiology and Data Science, Gastroenterology and hepatology, MOVE Research Institute, CCA - Innovative therapy, Other departments, Internal Medicine, and Gastroenterology & Hepatology
- Subjects
Pathology ,medicine.medical_specialty ,Bone density ,Bone Histomorphometry ,GASTROINTESTINAL-DISEASE ,Osteoporosis ,Inflammatory bowel disease ,Bone resorption ,Pathogenesis ,Biopsy ,medicine ,Hepatology ,medicine.diagnostic_test ,Bone Histomorphometry Osteocyte Apoptosis Inflammatory Bowel Disease Osteoporosis inflammatory-bowel-disease osteocyte density gastrointestinal-disease postmenopausal women osteoporosis raloxifene ,OSTEOCYTE DENSITY ,business.industry ,Osteocyte Apoptosis ,Inflammatory Bowel Disease ,Gastroenterology ,medicine.disease ,Crohn's Disease Activity Index ,medicine.anatomical_structure ,POSTMENOPAUSAL WOMEN ,RALOXIFENE ,Osteocyte ,business ,INFLAMMATORY-BOWEL-DISEASE - Abstract
Background & Aims: Crohn's disease (CD) is associated with an increased prevalence of osteoporosis, but the pathogenesis of this bone loss is only partly understood. We assessed bone structure and remodeling at the tissue level in patients with quiescent CD. We also investigated the roles of osteocyte density and apoptosis in CD-associated bone loss. Methods: The study included 23 patients with quiescent CD; this was a subgroup of patients from a large randomized, double-blind, placebo-controlled, multicenter trial. We obtained transiliac bone biopsy samples and performed histomorphometric analysis. Results: were compared with data from age- and sex-matched healthy individuals (controls). Results: Trabecular bone volume was decreased among patients with CD compared with controls (18.90% vs 25.49%; P < .001). The low bone volume was characterized by decreased trabecular thickness (120.61 vs 151.42 μm; P < .01). Bone formation and resorption were reduced, as indicated by a decreased mineral apposition rate (0.671 vs 0.746 μm/day; P < .01) and a low osteoclast number and surface area compared with controls and published values, respectively. In trabecular bone of patients with CD, osteocyte density and apoptosis were normal. The percentage of empty lacunae among patients was higher than that of published values in controls. Conclusions:: In adult patients with quiescent CD, bone histomorphometric analysis revealed a reduction in bone mass that was characterized by trabecular thinning. The CD-associated bone loss was caused by reduced bone formation, possibly as a consequence of decreased osteocyte viability in the patients' past. © 2011 AGA Institute.
- Published
- 2011
11. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men
- Author
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Rafiq, R., primary, van Schoor, N.M., additional, Sohl, E., additional, Zillikens, M.C., additional, Oosterwerff, M.M., additional, Schaap, L., additional, Lips, P., additional, and de Jongh, R.T., additional
- Published
- 2016
- Full Text
- View/download PDF
12. Towards optimal vitamin D status: determinants and consequences of vitamin D deficiency in the older population
- Author
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Sohl, E., Lips, Paul, van Schoor, Natasja, de Jongh, Renate, Epidemiology and Data Science, EMGO - Lifestyle, overweight and diabetes, Lips, P.T.A.M., van Schoor, N.M., de Jongh, R.T., and EMGO+ - Lifestyle, Overweight and Diabetes
- Abstract
promotiedatum: 26-6-2015 � prom-id: 10528
- Published
- 2015
13. Implementatie van het vitamine D-advies. Verslag van een expertmeeting
- Author
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Sohl, E., van Schoor, N.M., Epidemiology and Data Science, and EMGO - Lifestyle, overweight and diabetes
- Published
- 2015
14. Low vitamin D status is associated with more depressive symptoms in Dutch older adults
- Author
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Brouwer-Brolsma, E.M. (Elske), Dhonukshe-Rutten, R.A.M. (Rosalie), Wijngaarden, J.P. (Janneke) van, Zwaluw, N.L. (N.) van der, Sohl, E. (Evelien), In’t Veld, P.H., Dijk, S.C. (Suzanne) van, Swart, K.M.A. (Karin), Enneman, A.W. (Anke), Ham, A.C. (Annelies), Schoor, N.M. (Natasja) van, Velde, N. (Nathalie) van der, Uitterlinden, A.G. (André), Lips, P. (Paul), Feskens, E.J.M. (Edith), Groot, L.C.P.G.M. (Lisette) de, Brouwer-Brolsma, E.M. (Elske), Dhonukshe-Rutten, R.A.M. (Rosalie), Wijngaarden, J.P. (Janneke) van, Zwaluw, N.L. (N.) van der, Sohl, E. (Evelien), In’t Veld, P.H., Dijk, S.C. (Suzanne) van, Swart, K.M.A. (Karin), Enneman, A.W. (Anke), Ham, A.C. (Annelies), Schoor, N.M. (Natasja) van, Velde, N. (Nathalie) van der, Uitterlinden, A.G. (André), Lips, P. (Paul), Feskens, E.J.M. (Edith), and Groot, L.C.P.G.M. (Lisette) de
- Abstract
Purpose: The existence of vitamin D receptors in the brain points to a possible role of vitamin D in brain function. We examined the association of vitamin D status and vitamin D-related genetic make-up with depressive symptoms amongst 2839 Dutch older adults aged ≥65 years. Methods: 25-Hydroxyvitamin D (25(OH)D) was measured, and five ‘vitamin D-related genes’ were selected. Depressive symptoms were measured with the 15-point Geriatric Depression Scale. Results were expressed as the relative risk of the score of depressive symptoms by quartiles of 25(OH)D concentration or number of affected alleles, using the lowest quartile or minor allele group as reference. Results: A clear cross-sectional and pro
- Published
- 2016
- Full Text
- View/download PDF
15. Effects of two-year vitamin B12 and folic acid supplementation on depressive symptoms and quality of life in older adults with elevated homocysteine concentrations: Additional results from the B-Proof study, an RCT
- Author
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de Koning, E.J. (Elisa J.), Zwaluw, N.L. (N.) van der, Wijngaarden, J.P. (Janneke) van, Sohl, E. (Evelien), Brouwer-Brolsma, E.M. (Elske), Marwijk, H.W. (Harm) van, Enneman, A.W. (Anke), Swart, K.M.A. (Karin), Dijk, S.C. (Suzanne) van, Ham, A.C. (Annelies), Velde, N. (Nathalie) van der, Uitterlinden, A.G. (André), Penninx, B.W.J.H. (Brenda), Elders, P.J.M. (Petra), Lips, P. (Paul), Dhonukshe-Rutten, R.A.M. (Rosalie), Schoor, N.M. (Natasja) van, Groot, L.C.P.G.M. (Lisette) de, de Koning, E.J. (Elisa J.), Zwaluw, N.L. (N.) van der, Wijngaarden, J.P. (Janneke) van, Sohl, E. (Evelien), Brouwer-Brolsma, E.M. (Elske), Marwijk, H.W. (Harm) van, Enneman, A.W. (Anke), Swart, K.M.A. (Karin), Dijk, S.C. (Suzanne) van, Ham, A.C. (Annelies), Velde, N. (Nathalie) van der, Uitterlinden, A.G. (André), Penninx, B.W.J.H. (Brenda), Elders, P.J.M. (Petra), Lips, P. (Paul), Dhonukshe-Rutten, R.A.M. (Rosalie), Schoor, N.M. (Natasja) van, and Groot, L.C.P.G.M. (Lisette) de
- Abstract
Lowering elevated plasma homocysteine (Hcy) concentrations by supplementing vitamin B12 and folic acid may reduce depressive symptoms and improve health-related quality of life (HR-QoL) in older adults. This study aimed to test this hypothesis in a randomized controlled trial. Participants (N = 2919, ≥65 years, Hcy concentrations ≥12 µmol/L) received either 500 µg vitamin B12 and 400 µg folic acid daily or placebo for two years. Both tablets contained 15 µg vitamin D3. Depressive symptoms were measured with the Geriatric Depression Scale-15 (GDS-15). HR-QoL was assessed with the SF-12 Mental and Physical component summary scores and the EQ-5D Index score and Visual Analogue Scale. Differences in two-year change scores were analyzed with Analysis of Covariance (ANCOVA). Hcy concentrations decreased more in the intervention group, but two-year change scores of the GDS-15 and three of four HR-QoL measures did not differ between groups. The EQ-5D Index score declined less in the intervention group than in the placebo group (mean change 0.00 vs. −0.02, p = 0.004). In conclusion, two-year supplementation with vitamin B12 and folic acid in older adults with hyperhomocysteinemia showed that lowering Hcy concentrations does not reduce depressive symptoms, but it may have a small positive effect on HR-QoL.
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- 2016
- Full Text
- View/download PDF
16. A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study
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Swart, K.M.A. (Karin), Ham, A.C. (Annelies), Wijngaarden, J.P. (Janneke) van, Enneman, A.W. (Anke), Dijk, S.C. (Suzanne) van, Sohl, E. (Evelien), Brouwer-Brolsma, E.M. (Elske), Zwaluw, N.L. (N.) van der, Zillikens, M.C. (Carola), Dhonukshe-Rutten, R.A.M. (Rosalie), Velde, N. (Nathalie) van der, Brug, J. (Hans), Uitterlinden, A.G. (André), Groot, L.C.P.G.M. (Lisette) de, Lips, P. (Paul), Schoor, N.M. (Natasja) van, Swart, K.M.A. (Karin), Ham, A.C. (Annelies), Wijngaarden, J.P. (Janneke) van, Enneman, A.W. (Anke), Dijk, S.C. (Suzanne) van, Sohl, E. (Evelien), Brouwer-Brolsma, E.M. (Elske), Zwaluw, N.L. (N.) van der, Zillikens, M.C. (Carola), Dhonukshe-Rutten, R.A.M. (Rosalie), Velde, N. (Nathalie) van der, Brug, J. (Hans), Uitterlinden, A.G. (André), Groot, L.C.P.G.M. (Lisette) de, Lips, P. (Paul), and Schoor, N.M. (Natasja) van
- Abstract
Elevated homocysteine concentrations are associated with a decline in physical function in elderly persons. Homocysteine-lowering therapy may slow down this decline. This study aimed to examine the effect of a 2-year intervention of vitamin B12 and folic acid supplementation on physical performance, handgrip strength, and risk of falling in elderly subjects in a double-blind, randomized placebo-controlled trial. Participants aged ≥65 years with elevated plasma homocysteine concentrations [12–50 µmol/L (n = 2919)] were randomly assigned to daily supplementation of 500 µg vitamin B12, 400 µg folic acid, and 600 IU
- Published
- 2016
- Full Text
- View/download PDF
17. Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT
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Koning, EJ, van der Zwaluw, NL, Wijngaarden, JP, Sohl, E, Brouwer-Brolsma, EM, van Marwijk, HWJ, Enneman, Anke, Swart, KMA, Boon - van Dijk, Suzanne, Ham, Annelies, van der Velde, Nathalie, Uitterlinden, André, Penninx, BWJH, Elders, PJM, Lips, P, Dhonukshe-Rutten, RAM, Schoor, NM, de Groot, LCPGM (Lisette), Koning, EJ, van der Zwaluw, NL, Wijngaarden, JP, Sohl, E, Brouwer-Brolsma, EM, van Marwijk, HWJ, Enneman, Anke, Swart, KMA, Boon - van Dijk, Suzanne, Ham, Annelies, van der Velde, Nathalie, Uitterlinden, André, Penninx, BWJH, Elders, PJM, Lips, P, Dhonukshe-Rutten, RAM, Schoor, NM, and de Groot, LCPGM (Lisette)
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- 2016
18. Low vitamin D status is associated with more depressive symptoms in Dutch older adults
- Author
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Brouwer-Brolsma, EM, Dhonukshe-Rutten, RAM, Wijngaarden, JP, van der Zwaluw, NL, Sohl, E, in 't Veld, PH, Boon - van Dijk, Suzanne, Swart, KMA, Enneman, Anke, Ham, Annelies, Schoor, NM, van der Velde, Nathalie, Uitterlinden, André, Lips, P, Feskens, EJM, de Groot, LCPGM (Lisette), Brouwer-Brolsma, EM, Dhonukshe-Rutten, RAM, Wijngaarden, JP, van der Zwaluw, NL, Sohl, E, in 't Veld, PH, Boon - van Dijk, Suzanne, Swart, KMA, Enneman, Anke, Ham, Annelies, Schoor, NM, van der Velde, Nathalie, Uitterlinden, André, Lips, P, Feskens, EJM, and de Groot, LCPGM (Lisette)
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- 2016
19. A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study
- Author
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Swart, KMA, Ham, Annelies, Wijngaarden, JP, Enneman, Anke, Boon - van Dijk, Suzanne, Sohl, E, Brouwer-Brolsma, EM, van der Zwaluw, NL, Zillikens, M.C., Dhonukshe-Rutten, RAM, van der Velde, Nathalie, Brug, J, Uitterlinden, André, de Groot, LCPGM (Lisette), Lips, P, Schoor, NM, Swart, KMA, Ham, Annelies, Wijngaarden, JP, Enneman, Anke, Boon - van Dijk, Suzanne, Sohl, E, Brouwer-Brolsma, EM, van der Zwaluw, NL, Zillikens, M.C., Dhonukshe-Rutten, RAM, van der Velde, Nathalie, Brug, J, Uitterlinden, André, de Groot, LCPGM (Lisette), Lips, P, and Schoor, NM
- Abstract
Elevated homocysteine concentrations are associated with a decline in physical function in elderly persons. Homocysteine-lowering therapy may slow down this decline. This study aimed to examine the effect of a 2-year intervention of vitamin B12 and folic acid supplementation on physical performance, handgrip strength, and risk of falling in elderly subjects in a double-blind, randomized placebo-controlled trial. Participants aged a parts per thousand yen65 years with elevated plasma homocysteine concentrations [12-50 A mu mol/L (n = 2919)] were randomly assigned to daily supplementation of 500 A mu g vitamin B12, 400 A mu g folic acid, and 600 IU vitamin D3, or to placebo with 600 IU vitamin D3. Physical performance (range 0-12) and handgrip strength (kg) were measured at baseline and after 2 years. Falls were reported prospectively on a research calendar. Intention-to-treat (primary) and per-protocol (secondary) analyses were performed. Physical performance level and handgrip strength significantly decreased during the follow-up period, but this decline did not differ between groups. Moreover, time to first fall was not significantly different (HR: 1.0, 95 % CI 0.9-1.2). Secondary analyses on a per-protocol base identified an interaction effect with age on physical performance. In addition, the treatment was associated with higher follow-up scores on the walking test (cumulative OR: 1.3, 95 % CI 1.1-1.5). Two-year supplementation of vitamin B12 and folic acid was neither effective in reducing the age-related decline in physical performance and handgrip strength, nor in the prevention of falling in elderly persons. Despite the overall null-effect, the results provide indications for a positive effect of the intervention on gait, as well as on physical performance among compliant persons > 80 years. These effects should be further tested in future studies.
- Published
- 2016
20. Low vitamin D status is associated with more depressive symptoms in Dutch older adults
- Author
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Brouwer-Brolsma, E.M., Dhonukshe-Rutten, R.A.M., van Wijngaarden, J.P., van der Zwaluw, N.L., Sohl, E., in 't Veld, P.H., van Dijk, S.C., Swart, K.M.A., Enneman, A.W., Ham, A.C., van Schoor, N.M., van der Velde, N., Uitterlinden, A.G., Lips, P., Feskens, E.J.M., de Groot, C.P.G.M., Brouwer-Brolsma, E.M., Dhonukshe-Rutten, R.A.M., van Wijngaarden, J.P., van der Zwaluw, N.L., Sohl, E., in 't Veld, P.H., van Dijk, S.C., Swart, K.M.A., Enneman, A.W., Ham, A.C., van Schoor, N.M., van der Velde, N., Uitterlinden, A.G., Lips, P., Feskens, E.J.M., and de Groot, C.P.G.M.
- Abstract
Purpose The existence of vitamin D receptors in the brain points to a possible role of vitamin D in brain function. We examined the association of vitamin D status and vitamin D-related genetic make-up with depressive symptoms amongst 2839 Dutch older adults aged =65 years. Methods 25-Hydroxyvitamin D (25(OH)D) was measured, and five ‘vitamin D-related genes’ were selected. Depressive symptoms were measured with the 15-point Geriatric Depression Scale. Results were expressed as the relative risk of the score of depressive symptoms by quartiles of 25(OH)D concentration or number of affected alleles, using the lowest quartile or minor allele group as reference. Results A clear cross-sectional and prospective association between serum 25(OH)D and depressive symptom score was observed. Fully adjusted models indicated a 22 % (RR 0.78, 95 % CI 0.68–0.89), 21 % (RR 0.79, 95 % CI 0.68–0.90), and 18 % (RR 0.82, 95 % CI 0.71–0.95) lower score of depressive symptoms in people in the second, third, and fourth 25(OH)D quartiles, when compared to people in the first quartile (P for trend
- Published
- 2016
21. A randomized controlled trial to examine the effect of 2-year vitamin B12 and folic acid supplementation on physical performance, strength, and falling: additional findings from the B-PROOF study
- Author
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Swart, K.M.A., Ham, A.C., van Wijngaarden, J.P., Enneman, A.W., van Dijk, S.C., Sohl, E., Brouwer, E.M., van der Zwaluw, N.L., Zillikens, M.C., Dhonukshe-Rutten, R.A.M., van der Velde, N., Brug, J., Uitterlinden, A.G., de Groot, C.P.G.M., Lips, P., van Schoor, N.M., Swart, K.M.A., Ham, A.C., van Wijngaarden, J.P., Enneman, A.W., van Dijk, S.C., Sohl, E., Brouwer, E.M., van der Zwaluw, N.L., Zillikens, M.C., Dhonukshe-Rutten, R.A.M., van der Velde, N., Brug, J., Uitterlinden, A.G., de Groot, C.P.G.M., Lips, P., and van Schoor, N.M.
- Abstract
Elevated homocysteine concentrations are associated with a decline in physical function in elderly persons. Homocysteine-lowering therapy may slow down this decline. This study aimed to examine the effect of a 2-year intervention of vitamin B12 and folic acid supplementation on physical performance, handgrip strength, and risk of falling in elderly subjects in a double-blind, randomized placebo-controlled trial. Participants aged ≥65 years with elevated plasma homocysteine concentrations [12–50 µmol/L (n = 2919)] were randomly assigned to daily supplementation of 500 µg vitamin B12, 400 µg folic acid, and 600 IU vitamin D3, or to placebo with 600 IU vitamin D3. Physical performance (range 0–12) and handgrip strength (kg) were measured at baseline and after 2 years. Falls were reported prospectively on a research calendar. Intention-to-treat (primary) and per-protocol (secondary) analyses were performed. Physical performance level and handgrip strength significantly decreased during the follow-up period, but this decline did not differ between groups. Moreover, time to first fall was not significantly different (HR: 1.0, 95 % CI 0.9–1.2). Secondary analyses on a per-protocol base identified an interaction effect with age on physical performance. In addition, the treatment was associated with higher follow-up scores on the walking test (cumulative OR: 1.3, 95 % CI 1.1–1.5). Two-year supplementation of vitamin B12 and folic acid was neither effective in reducing the age-related decline in physical performance and handgrip strength, nor in the prevention of falling in elderly persons. Despite the overall null-effect, the results provide indications for a positive effect of the intervention on gait, as well as on physical performance among compliant persons >80 years. These effects should be further tested in future studies
- Published
- 2016
22. Non-linear associations between serum 25-OH vitamin D and indices of arterial stiffness and arteriosclerosis in an older population
- Author
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van Dijk, S.C., Sohl, E., Oudshoorn, C., Enneman, A.W., Ham, A.C., Swart, K.M.A., van Wijngaarden, J.P., Brouwer, E.M., van der Zwaluw, N.L., Uitterlinden, A.G., de Groot, C.P.G.M., Dhonukshe-Rutten, R.A.M., Lips, P., van Schoor, N.M., Blom, H.J., Geleijnse, J.M., Feskens, E.J.M., van Dijk, S.C., Sohl, E., Oudshoorn, C., Enneman, A.W., Ham, A.C., Swart, K.M.A., van Wijngaarden, J.P., Brouwer, E.M., van der Zwaluw, N.L., Uitterlinden, A.G., de Groot, C.P.G.M., Dhonukshe-Rutten, R.A.M., Lips, P., van Schoor, N.M., Blom, H.J., Geleijnse, J.M., and Feskens, E.J.M.
- Abstract
Background: several studies have been pointing towards a non-linear relationship between serum 25(OH)D and cardiovascular disease. Next to vitamin D deficiency, also higher levels of 25(OH)D have been reported to be associated with increased cardiovascular risk. We aimed to investigate the nature of the relationship between serum 25(OH)D and measures of arterial stiffness and arteriosclerosis in an elderly population. Design: cross-sectional. Setting/subjects: a subgroup of the B-PROOF study was included to determine associations between serum 25(OH)D and arterial stiffness and atherosclerosis (n = 567, 57% male, age 72.6 ± 5.6 years, mean serum 25(OH)D 54.6 ± 24.1 nmol/l). Methods: carotid intima media thickness (IMT) was assessed using ultrasonography and pulse wave velocity (PWV) was determined with applanation tonometry. Associations were tested using multivariable restricted cubic spline functions and stratified linear regression analysis. Results: the associations between serum 25(OH)D and carotid IMT or PWV were non-linear. Spline functions demonstrated a difference between 25(OH)D deficient and sufficient individuals. In serum 25(OH)D sufficient participants (=50 nmol/l; n = 287), a positive association with IMT and serum 25(OH)D was present (ß 1.24; 95%CI [0.002; 2.473]). PWV levels were slightly lower in vitamin D deficient individuals, but the association with 25(OH)D was not significant. Conclusion: our study demonstrates that associations of serum 25(OH)D and PWV and IMT in an elderly population are not linear. In particular from serum 25(OH)D levels of 50 nmol/l and up, there is a slight increase of IMT with increasing 25(OH)D levels.
- Published
- 2015
23. Serum 25-Hydroxyvitamin D is not Associated With Domain-Specific Cognitive Performance in Dutch Elderly
- Author
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Brouwer-Brolsma, EM, Dhonukshe-Rutten, RAM, Wijngaarden, JP, van der Zwaluw, NL, in t Veld, P, Kessels, RPC, Sohl, E, Boon - van Dijk, Suzanne, Schoor, NM, van der Velde, Nathalie, Uitterlinden, André, Lips, P, Feskens, EJM, de Groot, LCPGM (Lisette), Surgery, and Internal Medicine
- Published
- 2013
24. Low vitamin D status is associated with more depressive symptoms in Dutch older adults
- Author
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Brouwer-Brolsma, E. M., primary, Dhonukshe-Rutten, R. A. M., additional, van Wijngaarden, J. P., additional, van der Zwaluw, N. L., additional, Sohl, E., additional, In’t Veld, P. H., additional, van Dijk, S. C., additional, Swart, K. M. A., additional, Enneman, A. W., additional, Ham, A. C., additional, van Schoor, N. M., additional, van der Velde, N., additional, Uitterlinden, A. G., additional, Lips, P., additional, Feskens, E. J. M., additional, and de Groot, L. C. P. G. M., additional
- Published
- 2015
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25. The Association Between Vitamin D Status and Parameters for Bone Density and Quality is Modified by Body Mass Index
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Sohl, E., primary, de Jongh, R. T., additional, Swart, K. M. A., additional, Enneman, A. W., additional, van Wijngaarden, J. P., additional, van Dijk, S. C., additional, Ham, A. C., additional, van der Zwaluw, N. L., additional, Brouwer-Brolsma, E. M., additional, van der Velde, N., additional, de Groot, C. P. G. M., additional, te Velde, S. J., additional, Lips, P., additional, and van Schoor, N. M., additional
- Published
- 2014
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26. Non-linear associations between serum 25-OH vitamin D and indices of arterial stiffness and arteriosclerosis in an older population
- Author
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van Dijk, S. C., primary, Sohl, E., additional, Oudshoorn, C., additional, Enneman, A. W., additional, Ham, A. C., additional, Swart, K. M. A., additional, van Wijngaarden, J. P., additional, Brouwer-Brolsma, E. M., additional, van der Zwaluw, N. L., additional, Uitterlinden, A. G., additional, de Groot, L. C. P. G. M., additional, Dhonukshe-Rutten, R. A. M., additional, Lips, P., additional, van Schoor, N. M., additional, Blom, H. J., additional, Geleijnse, J. M., additional, Feskens, E. J., additional, Smulders, Y. M., additional, Zillikens, M. C., additional, de Jongh, R. T., additional, van den Meiracker, A. H., additional, Mattace Raso, F. U. S., additional, and van der Velde, N., additional
- Published
- 2014
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27. Effect of daily vitamin B12 and folic acid supplementation on fracture incidence in elderly with an elevated plasma homocysteine level: B-PROOF, a randomized controlled trial
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van, Wijngaarden JP, primary, Swart, KMA, additional, Enneman, AW, additional, Dhonukshe-Rutten, RAM, additional, van, Dijk SC, additional, Ham, AC, additional, Brouwer-Brolsma, EM, additional, van, der Zwaluw NL, additional, Sohl, E, additional, van, Meurs JBJ, additional, Zillikens, MC, additional, van, Schoor NM, additional, van, der Velde N, additional, Brug, J, additional, Uitterlinden, AG, additional, Lips, P, additional, and de, Groot CPGM, additional
- Published
- 2014
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28. Vitamin D status is associated with physical performance: the results of three independent cohorts
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Sohl, E., primary, de Jongh, R. T., additional, Heijboer, A. C., additional, Swart, K. M. A., additional, Brouwer-Brolsma, E. M., additional, Enneman, A. W., additional, de Groot, C. P. G. M., additional, van der Velde, N., additional, Dhonukshe-Rutten, R. A. M., additional, Lips, P., additional, and van Schoor, N. M., additional
- Published
- 2012
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29. Vitamin D status predicts functional limitations and its decline in two cohorts of the longitudinal aging study Amsterdam
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Sohl⁎, E., primary, de Jongh, R.T., additional, Lips, P., additional, and van Schoor, N.M., additional
- Published
- 2012
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30. The impact of medication on vitamin D status in older individuals
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Sohl, E, primary, van Schoor, N M, additional, de Jongh, R T, additional, de Vries, O J, additional, and Lips, P, additional
- Published
- 2012
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31. BURNS
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Sohl, E., primary
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- 1967
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32. Treatment-Resistant Depression Revisited: A Glimmer of Hope.
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Halaris A, Sohl E, and Whitham EA
- Abstract
Major Depressive Disorder (MDD) is a highly prevalent psychiatric disorder worldwide. It causes individual suffering, loss of productivity, increased health care costs and high suicide risk. Current pharmacologic interventions fail to produce at least partial response to approximately one third of these patients, and remission is obtained in approximately 30% of patients. This is known as Treatment-Resistant Depression (TRD). The burden of TRD exponentially increases the longer it persists, with a higher risk of impaired functional and social functioning, vast losses in quality of life and significant risk of somatic morbidity and suicidality. Different approaches have been suggested and utilized, but the results have not been encouraging. In this review article, we present new approaches to identify and correct potential causes of TRD, thereby reducing its prevalence and with it the overall burden of this disease entity. We will address potential contributory factors to TRD, most of which can be investigated in many laboratories as routine tests. We discuss endocrinological aberrations, notably, hypothalamic-pituitary-adrenal (HPA) axis dysregulation and thyroid and gonadal dysfunction. We address the role of Vitamin D in contributing to depression. Pharmacogenomic testing is being increasingly used to determine Single Nucleotide Polymorphisms in Cytochrome P450, Serotonin Transporter, COMT, folic acid conversion (MTHFR). As the role of immune system dysregulation is being recognized as potentially a major contributory factor to TRD, the measurement of C-reactive protein (CRP) and select immune biomarkers, where testing is available, can guide combination treatments with anti-inflammatory agents (e.g., selective COX-2 inhibitors) reversing treatment resistance. We focus on established and emerging test procedures, potential biomarkers and non-biologic assessments and interventions to apply personalized medicine to effectively manage treatment resistance in general and TRD specifically.
- Published
- 2021
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33. Effects of Two-Year Vitamin B 12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT.
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de Koning EJ, van der Zwaluw NL, van Wijngaarden JP, Sohl E, Brouwer-Brolsma EM, van Marwijk HW, Enneman AW, Swart KM, van Dijk SC, Ham AC, van der Velde N, Uitterlinden AG, Penninx BW, Elders PJ, Lips P, Dhonukshe-Rutten RA, van Schoor NM, and de Groot LC
- Subjects
- Age Factors, Aged, Biomarkers blood, Depression diagnosis, Depression etiology, Depression psychology, Double-Blind Method, Drug Combinations, Female, Humans, Hyperhomocysteinemia blood, Hyperhomocysteinemia diagnosis, Male, Netherlands, Psychiatric Status Rating Scales, Risk Factors, Time Factors, Treatment Outcome, Up-Regulation, Affect, Depression prevention & control, Dietary Supplements, Folic Acid administration & dosage, Homocysteine blood, Hyperhomocysteinemia drug therapy, Quality of Life, Vitamin B 12 administration & dosage
- Abstract
Lowering elevated plasma homocysteine (Hcy) concentrations by supplementing vitamin B
12 and folic acid may reduce depressive symptoms and improve health-related quality of life (HR-QoL) in older adults. This study aimed to test this hypothesis in a randomized controlled trial. Participants ( N = 2919, ≥65 years, Hcy concentrations ≥12 µmol/L) received either 500 µg vitamin B12 and 400 µg folic acid daily or placebo for two years. Both tablets contained 15 µg vitamin D₃. Depressive symptoms were measured with the Geriatric Depression Scale-15 (GDS-15). HR-QoL was assessed with the SF-12 Mental and Physical component summary scores and the EQ-5D Index score and Visual Analogue Scale. Differences in two-year change scores were analyzed with Analysis of Covariance (ANCOVA). Hcy concentrations decreased more in the intervention group, but two-year change scores of the GDS-15 and three of four HR-QoL measures did not differ between groups. The EQ-5D Index score declined less in the intervention group than in the placebo group (mean change 0.00 vs. -0.02, p = 0.004). In conclusion, two-year supplementation with vitamin B12 and folic acid in older adults with hyperhomocysteinemia showed that lowering Hcy concentrations does not reduce depressive symptoms, but it may have a small positive effect on HR-QoL., Competing Interests: The authors declare no conflict of interest. The funding sources had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.- Published
- 2016
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34. Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study.
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Brouwer-Brolsma EM, Vaes AMM, van der Zwaluw NL, van Wijngaarden JP, Swart KMA, Ham AC, van Dijk SC, Enneman AW, Sohl E, van Schoor NM, van der Velde N, Uitterlinden AG, Lips P, Feskens EJM, Dhonukshe-Rutten RAM, and de Groot LCPGM
- Subjects
- Aged, Aged, 80 and over, Cholestanetriol 26-Monooxygenase genetics, Cross-Sectional Studies, Cytochrome P450 Family 2 genetics, Dietary Supplements, Female, Humans, Male, Oxidoreductases Acting on CH-CH Group Donors genetics, Polymorphism, Single Nucleotide, Seasons, Sunlight, Vitamin D analogs & derivatives, Vitamin D blood, Vitamin D genetics, Vitamin D Deficiency blood, Vitamin D Deficiency prevention & control, Vitamin D3 24-Hydroxylase genetics, Vitamins genetics, Vitamin D therapeutic use, Vitamin D Deficiency epidemiology, Vitamin D Deficiency genetics, Vitamins therapeutic use
- Abstract
Background/objectives: The prevalence of vitamin D deficiency among seniors is high. Whereas sun exposure, vitamin D intake, genes, demographics, and lifestyle have been identified as being important determinants of vitamin D status, the impact of these factors is expected to differ across populations. To improve current prevention and treatment strategies, this study aimed to explore the main determinants of vitamin D status and its relative importance in a population of community-dwelling Dutch older adults., Methods/subjects: Serum 25-hydroxyvitamin D (25(OH)D) was measured in 2857 adults aged ≥65 years. Sun exposure was assessed with a structured questionnaire (n=1012), vitamin D intake using a Food Frequency Questionnaire (n=596), and data on genetic variation that may affect 25(OH)D status was obtained for 4 genes, DHCR7 (rs12785878), CYP2R1 (rs10741657), GC (rs2282679), and CYP24A1 (rs6013897) (n=2530)., Results: Serum 25(OH)D concentrations <50nmol/L were observed in 45% of the population; only 6% of these participants used vitamin D supplements. Sun exposure (being outside daily during summer: 66±25nmol/L vs not being outside daily during summer: 58±27nmol/L, P=0.02) and vitamin D intake (per unit μg/day during winter/spring: 3.1±0.75nmol/L, P<0.0001) were associated with higher 25(OH)D concentrations. Major allele carriers of SNPs related to DHCR7, CYP24A1, and GC, as well as CYP2R1 minor allele carriers had the highest 25(OH)D concentrations. Together, sun (R
2 =0.29), vitamin D intake (R2 =0.24), and genes (R2 =0.28) explained 35% (R2 =0.35) of the variation in 25(OH)D concentrations during summer/autumn period, when adjusted for age, sex, BMI, education, alcohol consumption, smoking, physical activity, and self-rated health status (n=185)., Conclusion: The investigated determinants explained 35% of 25(OH)D status. Of the three main determinants under study, sun exposure still appeared to be an important determinant of serum 25(OH)D in older individuals, closely followed by genes, and vitamin D intake. Given the low frequency of vitamin D supplement use in this population, promoting supplement use may be an inexpensive, easy, and effective strategy to fight vitamin D deficiency., (Copyright © 2015 Elsevier Ltd. All rights reserved.)- Published
- 2016
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35. Vitamin D, PTH and the risk of overall and disease-specific mortality: Results of the Longitudinal Aging Study Amsterdam.
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El Hilali J, de Koning EJ, van Ballegooijen AJ, Lips P, Sohl E, van Marwijk HWJ, Visser M, and van Schoor NM
- Subjects
- Aged, Aged, 80 and over, Alcohol Drinking physiopathology, Biomarkers blood, Body Mass Index, Cardiovascular Diseases diagnosis, Cardiovascular Diseases mortality, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neoplasms diagnosis, Neoplasms mortality, Netherlands epidemiology, Proportional Hazards Models, Quality of Life, Risk Factors, Sex Factors, Smoking physiopathology, Vitamin D blood, Aging blood, Cardiovascular Diseases blood, Neoplasms blood, Parathyroid Hormone blood, Vitamin D analogs & derivatives
- Abstract
Observational studies suggest that low concentrations of serum 25-hydroxyvitamin D (25(OH)D) and high concentrations of parathyroid hormone (PTH) are associated with a higher risk of mortality. The aim of this study was to examine whether 25(OH)D and PTH concentrations are independently associated with overall and disease-specific (cardiovascular and cancer-related) mortality in a large, prospective population-based cohort of older adults. Data from 1317 men and women (65-85 years) of the Longitudinal Aging Study Amsterdam were used. Cox proportional hazard analyses were used to examine whether 25(OH)D and PTH at baseline were associated with overall mortality (with a follow-up of 18 years) and disease-specific mortality (with a follow-up of 13 years). Compared to persons in the reference category of ≥75nmol/L, persons with serum 25(OH)D <25nmol/L (HR 1.46; 95% CI: 1.12-1.91) and 25-49.9nmol/L (HR 1.24; 95% CI: 1.01-1.53) had a significantly higher risk of overall mortality, as well as men with baseline PTH concentrations ≥7pmol/L (HR 2.54 (95% CI: 1.58-4.08)), compared to the reference category of <2.33pmol/L. The relationship of 25(OH)D with overall mortality was partly mediated by PTH. Furthermore, men with PTH concentrations of ≥7pmol/L (HR 3.22; 95% CI: 1.40-7.42) had a higher risk of cardiovascular mortality, compared to the reference category. No significant associations of 25(OH)D or PTH with cancer-related mortality were observed. Both 25(OH)D and PTH should be considered as important health markers., (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Published
- 2016
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36. Associations Between Statin Use and Physical Function in Older Adults from The Netherlands and Australia: Longitudinal Aging Study Amsterdam and Australian Longitudinal Study on Women's Health.
- Author
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van Boheemen L, Tett SE, Sohl E, Hugtenburg JG, van Schoor NM, and Peeters GM
- Subjects
- Adult, Aged, Australia epidemiology, Cross-Sectional Studies, Female, Humans, Logistic Models, Longitudinal Studies, Male, Middle Aged, Netherlands epidemiology, Prospective Studies, Surveys and Questionnaires, Aging drug effects, Drug Utilization statistics & numerical data, Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage, Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Motor Activity drug effects, Women's Health
- Abstract
Background: Statin therapy may cause myopathy, but long-term effects on physical function are unclear., Objective: We investigated whether statin use is associated with poorer physical function in two population-based cohorts of older adults., Methods: Data were from 691 men and women (aged 69-102 years in 2005/2006) in the LASA (Longitudinal Aging Study Amsterdam) and 5912 women (aged 79-84 years in 2005) in the ALSWH (Australian Longitudinal Study on Women's Health). Statin use and dose were sourced from containers (LASA) and administrative databases (ALSWH). Physical function was assessed using performance tests, questionnaires on functional limitations and the SF-12 (LASA) and SF-36 (ALSWH) questionnaires. Cross-sectional (both studies) and 3-year prospective associations (ALSWH) were analysed for different statin dosage using linear and logistic regression., Results: In total, 25 % of participants in LASA and 61 % in ALSWH used statins. In the cross-sectional models in LASA, statin users were less likely to have functional limitations (percentage of subjects with at least 1 limitation 63.9 vs. 64.2; odds ratio [OR] 0.6; 95 % confidence interval [CI] 0.3-0.9) and had better SF-12 physical component scores (mean [adjusted] 47.3 vs. 44.5; beta [B] = 2.8; 95 % CI 1.1-4.5); in ALSWH, statin users had better SF-36 physical component scores (mean [adjusted] 37.4 vs. 36.5; B = 0.9; 95 % CI 0.3-1.5) and physical functioning subscale scores (mean [adjusted] 55.1 vs. 52.6; B = 2.4; 95 % CI 1.1-3.8) than non-users. Similar associations were found for low- and high-dose users and in the prospective models. In contrast, no significant associations were found with performance tests., Conclusions: Two databases from longitudinal population studies in older adults gave comparable results, even though different outcome measures were used. In these two large cohorts, statin use was associated with better self-perceived physical function.
- Published
- 2016
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37. A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study.
- Author
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Swart KM, Ham AC, van Wijngaarden JP, Enneman AW, van Dijk SC, Sohl E, Brouwer-Brolsma EM, van der Zwaluw NL, Zillikens MC, Dhonukshe-Rutten RA, van der Velde N, Brug J, Uitterlinden AG, de Groot LC, Lips P, and van Schoor NM
- Subjects
- Accidental Falls prevention & control, Aged, Aged, 80 and over, Aging drug effects, Aging physiology, Dietary Supplements, Female, Homocysteine blood, Humans, Male, Osteoporotic Fractures epidemiology, Physical Fitness, Accidental Falls statistics & numerical data, Folic Acid administration & dosage, Hand Strength physiology, Motor Activity drug effects, Vitamin B 12 administration & dosage
- Abstract
Elevated homocysteine concentrations are associated with a decline in physical function in elderly persons. Homocysteine-lowering therapy may slow down this decline. This study aimed to examine the effect of a 2-year intervention of vitamin B12 and folic acid supplementation on physical performance, handgrip strength, and risk of falling in elderly subjects in a double-blind, randomized placebo-controlled trial. Participants aged ≥65 years with elevated plasma homocysteine concentrations [12-50 µmol/L (n = 2919)] were randomly assigned to daily supplementation of 500 µg vitamin B12, 400 µg folic acid, and 600 IU vitamin D3, or to placebo with 600 IU vitamin D3. Physical performance (range 0-12) and handgrip strength (kg) were measured at baseline and after 2 years. Falls were reported prospectively on a research calendar. Intention-to-treat (primary) and per-protocol (secondary) analyses were performed. Physical performance level and handgrip strength significantly decreased during the follow-up period, but this decline did not differ between groups. Moreover, time to first fall was not significantly different (HR: 1.0, 95% CI 0.9-1.2). Secondary analyses on a per-protocol base identified an interaction effect with age on physical performance. In addition, the treatment was associated with higher follow-up scores on the walking test (cumulative OR: 1.3, 95% CI 1.1-1.5). Two-year supplementation of vitamin B12 and folic acid was neither effective in reducing the age-related decline in physical performance and handgrip strength, nor in the prevention of falling in elderly persons. Despite the overall null-effect, the results provide indications for a positive effect of the intervention on gait, as well as on physical performance among compliant persons >80 years. These effects should be further tested in future studies.
- Published
- 2016
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38. Non-linear associations between serum 25-OH vitamin D and indices of arterial stiffness and arteriosclerosis in an older population.
- Author
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van Dijk SC, Sohl E, Oudshoorn C, Enneman AW, Ham AC, Swart KM, van Wijngaarden JP, Brouwer-Brolsma EM, van der Zwaluw NL, Uitterlinden AG, de Groot LC, Dhonukshe-Rutten RA, Lips P, van Schoor NM, Blom HJ, Geleijnse JM, Feskens EJ, Smulders YM, Zillikens MC, de Jongh RT, van den Meiracker AH, Mattace Raso FU, and van der Velde N
- Subjects
- Age Factors, Aged, Aged, 80 and over, Aging blood, Arteriosclerosis blood, Arteriosclerosis diagnosis, Arteriosclerosis physiopathology, Biomarkers blood, Carotid Intima-Media Thickness, Cross-Sectional Studies, Female, Humans, Linear Models, Male, Manometry, Multivariate Analysis, Nonlinear Dynamics, Pulse Wave Analysis, Risk Factors, Vitamin D blood, Arteriosclerosis etiology, Vascular Stiffness, Vitamin D analogs & derivatives
- Abstract
Background: several studies have been pointing towards a non-linear relationship between serum 25(OH)D and cardiovascular disease. Next to vitamin D deficiency, also higher levels of 25(OH)D have been reported to be associated with increased cardiovascular risk. We aimed to investigate the nature of the relationship between serum 25(OH)D and measures of arterial stiffness and arteriosclerosis in an elderly population., Design: cross-sectional., Setting/subjects: a subgroup of the B-PROOF study was included to determine associations between serum 25(OH)D and arterial stiffness and atherosclerosis (n = 567, 57% male, age 72.6 ± 5.6 years, mean serum 25(OH)D 54.6 ± 24.1 nmol/l)., Methods: carotid intima media thickness (IMT) was assessed using ultrasonography and pulse wave velocity (PWV) was determined with applanation tonometry. Associations were tested using multivariable restricted cubic spline functions and stratified linear regression analysis., Results: the associations between serum 25(OH)D and carotid IMT or PWV were non-linear. Spline functions demonstrated a difference between 25(OH)D deficient and sufficient individuals. In serum 25(OH)D sufficient participants (≥50 nmol/l; n = 287), a positive association with IMT and serum 25(OH)D was present (β 1.24; 95%CI [0.002; 2.473]). PWV levels were slightly lower in vitamin D deficient individuals, but the association with 25(OH)D was not significant., Conclusion: our study demonstrates that associations of serum 25(OH)D and PWV and IMT in an elderly population are not linear. In particular from serum 25(OH)D levels of 50 nmol/l and up, there is a slight increase of IMT with increasing 25(OH)D levels., (© The Author 2014. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2015
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39. [Implementation of the Dutch vitamin D supplementation advice: report of an expert meeting].
- Author
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Sohl E and van Schoor NM
- Subjects
- Aged, Emigrants and Immigrants, Female, Health Promotion, Health Services Needs and Demand, Humans, Male, Middle Aged, Netherlands epidemiology, Risk Factors, Awareness, Dietary Supplements statistics & numerical data, Vitamin D administration & dosage, Vitamin D Deficiency prevention & control, Vulnerable Populations
- Abstract
In 2012, the Dutch Health Council published updated advice on vitamin D supplementation in the population of the Netherlands. Although implementation of the advice has commenced, progress is slow. The bottlenecks in implementation were highlighted at a national expert meeting and ideas formulated for improvements. Implementation is rendered more difficult because of the complex mix of lack of awareness of the advice, the reimbursement system of the health insurance companies and a lack of clarity regarding price and dosage differences of the supplements. Existing contact opportunities with healthcare professionals, such as when the flu vaccination is given, need to be used to provide information so as to improve the implementation. The children's health clinic can be used to inform the whole family about supplementation. In nursing and care homes, vitamin D supplementation should be instituted as standard and seen as an indicator of responsible care. It is important to prioritize target groups. The initial focus must be on the most vulnerable group, the inhabitants of nursing and care homes. The second priority must be given to the elderly living independently and to non-western immigrants.
- Published
- 2015
40. Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial.
- Author
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van Wijngaarden JP, Swart KM, Enneman AW, Dhonukshe-Rutten RA, van Dijk SC, Ham AC, Brouwer-Brolsma EM, van der Zwaluw NL, Sohl E, van Meurs JB, Zillikens MC, van Schoor NM, van der Velde N, Brug J, Uitterlinden AG, Lips P, and de Groot LC
- Subjects
- Aged, Aged, 80 and over, Dose-Response Relationship, Drug, Double-Blind Method, Endpoint Determination, Female, Follow-Up Studies, Humans, Hyperhomocysteinemia blood, Hyperhomocysteinemia drug therapy, Incidence, Male, Motor Activity, Netherlands, Risk Factors, Treatment Outcome, Dietary Supplements, Folic Acid administration & dosage, Homocysteine blood, Osteoporotic Fractures epidemiology, Osteoporotic Fractures prevention & control, Vitamin B 12 administration & dosage
- Abstract
Background: Elevated plasma homocysteine concentrations are a risk factor for osteoporotic fractures. Lowering homocysteine with combined vitamin B-12 and folic acid supplementation may reduce fracture risk., Objective: This study [B-vitamins for the PRevention Of Osteoporotic Fractures (B-PROOF)] aimed to determine whether vitamin B-12 and folic acid supplementation reduces osteoporotic fracture incidence in hyperhomocysteinemic elderly individuals., Design: This was a double-blind, randomized, placebo-controlled trial in 2919 participants aged ≥65 y with elevated homocysteine concentrations (12-50 μmol/L). Participants were assigned to receive daily 500 μg vitamin B-12 plus 400 μg folic acid or placebo supplementation for 2 y. Both intervention and placebo tablets also contained 600 IU vitamin D3. The primary endpoint was time to first osteoporotic fracture. Exploratory prespecified subgroup analyses were performed in men and women and in individuals younger than and older than age 80 y. Data were analyzed according to intention-to-treat and per-protocol principles., Results: Osteoporotic fractures occurred in 61 persons (4.2%) in the intervention group and 75 persons (5.1%) in the placebo group. Osteoporotic fracture risk was not significantly different between groups in the intention-to-treat analyses (HR: 0.84; 95% CI: 0.58, 1.21) or per-protocol analyses (HR: 0.81; 95% CI: 0.54, 1.21). For persons aged >80 y, in per-protocol analyses, osteoporotic fracture risk was lower in the intervention group than in the placebo group (HR: 0.27; 95% CI: 0.10, 0.74). The total number of adverse events (including mortality) did not differ between groups. However, 63 and 42 participants in the intervention and placebo groups, respectively, reported incident cancer (HR: 1.56; 95% CI: 1.04, 2.31)., Conclusions: These data show that combined vitamin B-12 and folic acid supplementation had no effect on osteoporotic fracture incidence in this elderly population. Exploratory subgroup analyses suggest a beneficial effect on osteoporotic fracture prevention in compliant persons aged >80 y. However, treatment was also associated with increased incidence of cancer, although the study was not designed for assessing cancer outcomes. Therefore, vitamin B-12 plus folic acid supplementation cannot be recommended at present for fracture prevention in elderly people. The B-PROOF study was registered with the Netherlands Trial Register (trialregister.nl) as NTR1333 and at clinicaltrials.gov as NCT00696414., (© 2014 American Society for Nutrition.)
- Published
- 2014
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41. Associations between medication use and homocysteine levels in an older population, and potential mediation by vitamin B12 and folate: data from the B-PROOF Study.
- Author
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Ham AC, Enneman AW, van Dijk SC, Oliai Araghi S, Swart KM, Sohl E, van Wijngaarden JP, van der Zwaluw NL, Brouwer-Brolsma EM, Dhonukshe-Rutten RA, van Schoor NM, van der Cammen TJ, Zillikens MC, de Jonge R, Lips P, de Groot LC, van Meurs JB, Uitterlinden AG, Witkamp RF, Stricker BH, and van der Velde N
- Subjects
- Aged, Diuretics administration & dosage, Female, Folic Acid administration & dosage, Health Services for the Aged, Humans, Male, Metformin administration & dosage, Netherlands, Osteoporosis epidemiology, Population Surveillance, Vitamin B 12 administration & dosage, Homocysteine blood, Vitamin B 12 Deficiency blood
- Abstract
Background: Elevated homocysteine levels are a risk indicator for cardiovascular disease, fractures and cognitive decline. Previous studies indicated associations between homocysteine levels and medication use, including antihypertensive, lipid-lowering and antidiabetic medication. However, results were often contradictory and inconclusive. Our objective was to study the associations established previously in more detail by sub-classifying medication groups, and investigate the potential mediating role of vitamin B12 and folate status., Materials and Methods: Baseline data from the B-PROOF (B-vitamins for the PRevention Of Osteoporotic Fractures) study were used. We included 2,912 participants aged ≥65 years, with homocysteine levels of 12-50 μmol/L and creatinine levels ≤150 μmol/L, for whom self-reported medication data were available. We used multivariable linear regression models and analysis of covariance to assess the association between medication use and plasma homocysteine levels, and the potential mediation by serum vitamin B12 and folate., Results: The mean age was 74 years (standard deviation, 6.5), 50 % were women, and median homocysteine levels were 14 µmol/L [interquartile range, 13-17 µmol/L]. Higher mean homocysteine levels were observed in users vs. non-users for diuretics (15.2 vs. 14.9, p = 0.043), high-ceiling sulphonamide diuretics (16.0 vs. 14.9, p < 0.001), medication acting via the renin-angiotensin system (15.2 vs. 14.9, p = 0.029) and metformin (15.6 vs. 15.1, p = 0.006). Non-selective β-blocker use was associated with lower mean homocysteine levels (14.4 vs. 15.0, p = 0.019). Only this association was mediated by an underlying association with vitamin B12 and folate levels., Conclusion: The associations between homocysteine levels and medication use appear to be fairly modest. Our results suggest that medication use is unlikely to contribute to clinically relevant changes in plasma homocysteine levels.
- Published
- 2014
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42. Prediction of vitamin D deficiency by simple patient characteristics.
- Author
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Sohl E, Heymans MW, de Jongh RT, den Heijer M, Visser M, Merlijn T, Lips P, and van Schoor NM
- Subjects
- Aged, Aged, 80 and over, Bayes Theorem, Female, Humans, Logistic Models, Longitudinal Studies, Male, Middle Aged, Netherlands, Prevalence, Risk Factors, Vitamin D Deficiency blood, Vitamin D blood, Vitamin D Deficiency diagnosis, Vitamin D Deficiency epidemiology
- Abstract
Background: Vitamin D status is currently diagnosed by measuring serum 25-hydroxyvitamin D [25(OH)D]., Objective: This study aimed to develop a risk profile that can be used to easily identify older individuals at high risk of vitamin D deficiency., Design: This study was performed within the Longitudinal Aging Study Amsterdam, an ongoing cohort study in a representative sample of the Dutch older population (n = 1509 for the development sample and n = 1100 for the validation sample). Prediction models for serum 25(OH)D concentrations <50 and <30 nmol/L were developed by using backward logistic regression. Risk scores were calculated by dividing the individual regression coefficients by the regression coefficient with the lowest β to create simple scores., Results: Serum 25(OH)D concentrations <50 and <30 nmol/L were present in 46.2% and 17.5% of participants, respectively. The model for the prediction of concentrations <50 nmol/L consisted of 13 easily assessable predictors, whereas the model for concentrations <30 nmol/L contained 10 predictors. The resulting areas under the curve (AUCs) were 0.78 and 0.80, respectively. The AUC in the external validation data set was 0.71 for the <50-nmol/L model. At a cutoff of 58 in total risk score (range: 8-97), the model predicted concentrations <50 nmol/L with a sensitivity of 61% and a specificity of 82%, whereas these values were 61% and 84%, respectively, at a cutoff of 110 in the total risk score (range: 6-204) in the model for concentrations <30 nmol/L., Conclusions: Two total risk scores, including 13 or 10 predictors that can easily be assessed, were developed and are able to predict serum 25(OH)D concentrations <50 and <30 nmol/L accurately. These risk scores may be useful in clinical practice to identify persons at risk of vitamin D deficiency.
- Published
- 2014
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