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Recent years witnessed remarkable progress in computational histopathology, largely fueled by deep learning. This brought the clinical adoption of deep learning-based tools within reach, promising significant benefits to healthcare, offering a valuable second opinion on diagnoses, streamlining complex tasks, and mitigating the risks of inconsistency and bias in clinical decisions. However, a well-known challenge is that deep learning models may contain up to billions of parameters; supervising their training effectively would require vast labeled datasets to achieve reliable generalization and noise resilience. In medical imaging, particularly histopathology, amassing such extensive labeled data collections places additional demands on clinicians and incurs higher costs, which hinders the art's progress. Addressing this challenge, researchers devised various strategies for leveraging deep learning with limited data and annotation availability. In this paper, we present a comprehensive review of deep learning applications in histopathology, with a focus on the challenges posed by data scarcity over the past decade. We systematically categorize and compare various approaches, evaluate their distinct contributions using benchmarking tables, and highlight their respective advantages and limitations. Additionally, we address gaps in existing reviews and identify underexplored research opportunities, underscoring the potential for future advancements in this field., Comment: 36 pages

Deep supervised learning models require high volume of labeled data to attain sufficiently good results. Although, the practice of gathering and annotating such big data is costly and laborious. Recently, the application of self supervised learning (SSL) in vision tasks has gained significant attention. The intuition behind SSL is to exploit the synchronous relationships within the data as a form of self-supervision, which can be versatile. In the current big data era, most of the data is unlabeled, and the success of SSL thus relies in finding ways to utilize this vast amount of unlabeled data available. Thus it is better for deep learning algorithms to reduce reliance on human supervision and instead focus on self-supervision based on the inherent relationships within the data. With the advent of ViTs, which have achieved remarkable results in computer vision, it is crucial to explore and understand the various SSL mechanisms employed for training these models specifically in scenarios where there is limited labelled data available. In this survey, we develop a comprehensive taxonomy of systematically classifying the SSL techniques based upon their representations and pre-training tasks being applied. Additionally, we discuss the motivations behind SSL, review popular pre-training tasks, and highlight the challenges and advancements in this field. Furthermore, we present a comparative analysis of different SSL methods, evaluate their strengths and limitations, and identify potential avenues for future research., Comment: 34 Pages, 5 Figures, 7 Tables

Transformers, due to their ability to learn long range dependencies, have overcome the shortcomings of convolutional neural networks (CNNs) for global perspective learning. Therefore, they have gained the focus of researchers for several vision related tasks including medical diagnosis. However, their multi-head attention module only captures global level feature representations, which is insufficient for medical images. To address this issue, we propose a Channel Boosted Hybrid Vision Transformer (CB HVT) that uses transfer learning to generate boosted channels and employs both transformers and CNNs to analyse lymphocytes in histopathological images. The proposed CB HVT comprises five modules, including a channel generation module, channel exploitation module, channel merging module, region-aware module, and a detection and segmentation head, which work together to effectively identify lymphocytes. The channel generation module uses the idea of channel boosting through transfer learning to extract diverse channels from different auxiliary learners. In the CB HVT, these boosted channels are first concatenated and ranked using an attention mechanism in the channel exploitation module. A fusion block is then utilized in the channel merging module for a gradual and systematic merging of the diverse boosted channels to improve the network's learning representations. The CB HVT also employs a proposal network in its region aware module and a head to effectively identify objects, even in overlapping regions and with artifacts. We evaluated the proposed CB HVT on two publicly available datasets for lymphocyte assessment in histopathological images. The results show that CB HVT outperformed other state of the art detection models, and has good generalization ability, demonstrating its value as a tool for pathologists., Comment: IEEE Access (2023)

Vision transformers have become popular as a possible substitute to convolutional neural networks (CNNs) for a variety of computer vision applications. These transformers, with their ability to focus on global relationships in images, offer large learning capacity. However, they may suffer from limited generalization as they do not tend to model local correlation in images. Recently, in vision transformers hybridization of both the convolution operation and self-attention mechanism has emerged, to exploit both the local and global image representations. These hybrid vision transformers, also referred to as CNN-Transformer architectures, have demonstrated remarkable results in vision applications. Given the rapidly growing number of hybrid vision transformers, it has become necessary to provide a taxonomy and explanation of these hybrid architectures. This survey presents a taxonomy of the recent vision transformer architectures and more specifically that of the hybrid vision transformers. Additionally, the key features of these architectures such as the attention mechanisms, positional embeddings, multi-scale processing, and convolution are also discussed. In contrast to the previous survey papers that are primarily focused on individual vision transformer architectures or CNNs, this survey uniquely emphasizes the emerging trend of hybrid vision transformers. By showcasing the potential of hybrid vision transformers to deliver exceptional performance across a range of computer vision tasks, this survey sheds light on the future directions of this rapidly evolving architecture., Comment: Pages: 84, Figures: 16

The digitization of different components of industry and inter-connectivity among indigenous networks have increased the risk of network attacks. Designing an intrusion detection system to ensure security of the industrial ecosystem is difficult as network traffic encompasses various attack types, including new and evolving ones with minor changes. The data used to construct a predictive model for computer networks has a skewed class distribution and limited representation of attack types, which differ from real network traffic. These limitations result in dataset shift, negatively impacting the machine learning models' predictive abilities and reducing the detection rate against novel attacks. To address the challenges, we propose a novel deep neural network based Meta-Learning framework; INformation FUsion and Stacking Ensemble (INFUSE) for network intrusion detection. First, a hybrid feature space is created by integrating decision and feature spaces. Five different classifiers are utilized to generate a pool of decision spaces. The feature space is then enriched through a deep sparse autoencoder that learns the semantic relationships between attacks. Finally, the deep Meta-Learner acts as an ensemble combiner to analyze the hybrid feature space and make a final decision. Our evaluation on stringent benchmark datasets and comparison to existing techniques showed the effectiveness of INFUSE with an F-Score of 0.91, Accuracy of 91.6%, and Recall of 0.94 on the Test+ dataset, and an F-Score of 0.91, Accuracy of 85.6%, and Recall of 0.87 on the stringent Test-21 dataset. These promising results indicate the strong generalization capability and the potential to detect network attacks., Comment: Pages: 15, Figures: 10 and Tables: 9

The Coronavirus (COVID-19) outbreak in December 2019 has become an ongoing threat to humans worldwide, creating a health crisis that infected millions of lives, as well as devastating the global economy. Deep learning (DL) techniques have proved helpful in analysis and delineation of infectious regions in radiological images in a timely manner. This paper makes an in-depth survey of DL techniques and draws a taxonomy based on diagnostic strategies and learning approaches. DL techniques are systematically categorized into classification, segmentation, and multi-stage approaches for COVID-19 diagnosis at image and region level analysis. Each category includes pre-trained and custom-made Convolutional Neural Network architectures for detecting COVID-19 infection in radiographic imaging modalities; X-Ray, and Computer Tomography (CT). Furthermore, a discussion is made on challenges in developing diagnostic techniques such as cross-platform interoperability and examining imaging modality. Similarly, a review of the various methodologies and performance measures used in these techniques is also presented. This survey provides an insight into the promising areas of research in DL for analyzing radiographic images, and further accelerates the research in designing customized DL based diagnostic tools for effectively dealing with new variants of COVID-19 and emerging challenges., Comment: Pages: 44, Figures: 7, Tables: 14

COVID-19 is a highly contagious respiratory infection that has affected a large population across the world and continues with its devastating consequences. It is imperative to detect COVID-19 at the earliest to limit the span of infection. In this work, a new classification technique CB-STM-RENet based on deep Convolutional Neural Network (CNN) and Channel Boosting is proposed for the screening of COVID-19 in chest X-Rays. In this connection, to learn the COVID-19 specific radiographic patterns, a new convolution block based on split-transform-merge (STM) is developed. This new block systematically incorporates region and edge-based operations at each branch to capture the diverse set of features at various levels, especially those related to region homogeneity, textural variations, and boundaries of the infected region. The learning and discrimination capability of the proposed CNN architecture is enhanced by exploiting the Channel Boosting idea that concatenates the auxiliary channels along with the original channels. The auxiliary channels are generated from the pre-trained CNNs using Transfer Learning. The effectiveness of the proposed technique CB-STM-RENet is evaluated on three different datasets of chest X-Rays namely CoV-Healthy-6k, CoV-NonCoV-10k, and CoV-NonCoV-15k. The performance comparison of the proposed CB-STM-RENet with the existing techniques exhibits high performance both in discriminating COVID-19 chest infections from Healthy, as well as, other types of chest infections. CB-STM-RENet provides the highest performance on all these three datasets; especially on the stringent CoV-NonCoV-15k dataset. The good detection rate (97%), and high precision (93%) of the proposed technique suggest that it can be adapted for the diagnosis of COVID-19 infected patients. The test code is available at https://github.com/PRLAB21/COVID-19-Detection-System-using-Chest-X-Ray-Images., Comment: Pages: 26 Tables: 3 Figures: 10 Equations: 8

COVID-19 is a global health problem. Consequently, early detection and analysis of the infection patterns are crucial for controlling infection spread as well as devising a treatment plan. This work proposes a two-stage deep Convolutional Neural Networks (CNNs) based framework for delineation of COVID-19 infected regions in Lung CT images. In the first stage, initially, COVID-19 specific CT image features are enhanced using a two-level discrete wavelet transformation. These enhanced CT images are then classified using the proposed custom-made deep CoV-CTNet. In the second stage, the CT images classified as infectious images are provided to the segmentation models for the identification and analysis of COVID-19 infectious regions. In this regard, we propose a novel semantic segmentation model CoV-RASeg, which systematically uses average and max pooling operations in the encoder and decoder blocks. This systematic utilization of max and average pooling operations helps the proposed CoV-RASeg in simultaneously learning both the boundaries and region homogeneity. Moreover, the idea of attention is incorporated to deal with mildly infected regions. The proposed two-stage framework is evaluated on a standard Lung CT image dataset, and its performance is compared with the existing deep CNN models. The performance of the proposed CoV-CTNet is evaluated using Mathew Correlation Coefficient (MCC) measure (0.98) and that of proposed CoV-RASeg using Dice Similarity (DS) score (0.95). The promising results on an unseen test set suggest that the proposed framework has the potential to help the radiologists in the identification and analysis of COVID-19 infected regions., Comment: Pages: 32, Tables: 6, Figures: 14

Empirical evaluation of breast tissue biopsies for mitotic nuclei detection is considered an important prognostic biomarker in tumor grading and cancer progression. However, automated mitotic nuclei detection poses several challenges because of the unavailability of pixel-level annotations, different morphological configurations of mitotic nuclei, their sparse representation, and close resemblance with non-mitotic nuclei. These challenges undermine the precision of the automated detection model and thus make detection difficult in a single phase. This work proposes an end-to-end detection system for mitotic nuclei identification in breast cancer histopathological images. Deep object detection-based Mask R-CNN is adapted for mitotic nuclei detection that initially selects the candidate mitotic region with maximum recall. However, in the second phase, these candidate regions are refined by multi-object loss function to improve the precision. The performance of the proposed detection model shows improved discrimination ability (F-score of 0.86) for mitotic nuclei with significant precision (0.86) as compared to the two-stage detection models (F-score of 0.701) on TUPAC16 dataset. Promising results suggest that the deep object detection-based model has the potential to learn the characteristic features of mitotic nuclei from weakly annotated data and suggests that it can be adapted for the identification of other nuclear bodies in histopathological images., Comment: Tables: 4, Figures 11, Pages: 21

Deep Convolutional Neural Network (CNN) is a special type of Neural Networks, which has shown exemplary performance on several competitions related to Computer Vision and Image Processing. Some of the exciting application areas of CNN include Image Classification and Segmentation, Object Detection, Video Processing, Natural Language Processing, and Speech Recognition. The powerful learning ability of deep CNN is primarily due to the use of multiple feature extraction stages that can automatically learn representations from the data. The availability of a large amount of data and improvement in the hardware technology has accelerated the research in CNNs, and recently interesting deep CNN architectures have been reported. Several inspiring ideas to bring advancements in CNNs have been explored, such as the use of different activation and loss functions, parameter optimization, regularization, and architectural innovations. However, the significant improvement in the representational capacity of the deep CNN is achieved through architectural innovations. Notably, the ideas of exploiting spatial and channel information, depth and width of architecture, and multi-path information processing have gained substantial attention. Similarly, the idea of using a block of layers as a structural unit is also gaining popularity. This survey thus focuses on the intrinsic taxonomy present in the recently reported deep CNN architectures and, consequently, classifies the recent innovations in CNN architectures into seven different categories. These seven categories are based on spatial exploitation, depth, multi-path, width, feature-map exploitation, channel boosting, and attention. Additionally, the elementary understanding of CNN components, current challenges, and applications of CNN are also provided., Comment: Number of Pages: 70, Number of Figures: 11, Number of Tables: 11. Artif Intell Rev (2020)

We present a novel architectural enhancement of Channel Boosting in a deep convolutional neural network (CNN). This idea of Channel Boosting exploits both the channel dimension of CNN (learning from multiple input channels) and Transfer learning (TL). TL is utilized at two different stages; channel generation and channel exploitation. In the proposed methodology, a deep CNN is boosted by various channels available through TL from already trained Deep Neural Networks, in addition to its original channel. The deep architecture of CNN then exploits the original and boosted channels down the stream for learning discriminative patterns. Churn prediction in telecom is a challenging task due to the high dimensionality and imbalanced nature of the data. Therefore, churn prediction data is used to evaluate the performance of the proposed Channel Boosted CNN (CB CNN). In the first phase, informative discriminative features are being extracted using a stacked autoencoder, and then in the second phase, these features are combined with the original features to form Channel Boosted images. Finally, the knowledge gained by a pretrained CNN is exploited by employing TL. The results are promising and show the ability of the Channel Boosting concept in learning complex classification problems by discerning even minute differences in churners and nonchurners. The proposed work validates the concept observed from the evolution of recent CNN architectures that the innovative restructuring of a CNN architecture may increase the networks representative capacity., Comment: 24 Pages, 5 Figures, 1 Table