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2. Whole-Genome Sequencing to Predict Antimicrobial Susceptibility Profiles in Neisseria gonorrhoeae

Author

Bristow, Claire C, Mortimer, Tatum D, Morris, Sheldon, Grad, Yonatan H, Soge, Olusegun O, Wakatake, Erika, Pascual, Rushlenne, Murphy, Sara McCurdy, Fryling, Kyra E, Adamson, Paul C, Dillon, Jo-Anne, Parmar, Nidhi R, Le, Hai Ha Long, Van Le, Hung, Ureña, Reyna Margarita Ovalles, Mitchev, Nireshni, Mlisana, Koleka, Wi, Teodora, Dickson, Samuel P, and Klausner, Jeffrey D

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Microbiology, Clinical Sciences, Medical Microbiology, Oncology and Carcinogenesis, Sexually Transmitted Infections, Antimicrobial Resistance, Biodefense, Biotechnology, Genetics, Infectious Diseases, Emerging Infectious Diseases, Clinical Research, Infection, Good Health and Well Being, Humans, Neisseria gonorrhoeae, Anti-Bacterial Agents, Gonorrhea, Ciprofloxacin, Anti-Infective Agents, Microbial Sensitivity Tests, Drug Resistance, Bacterial, Azithromycin, antimicrobial susceptibility testing, whole-genome sequencing, Medical and Health Sciences, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundNeisseria gonorrhoeae is a major public health problem due to increasing incidence and antimicrobial resistance. Genetic markers of reduced susceptibility have been identified; the extent to which those are representative of global antimicrobial resistance is unknown. We evaluated the performance of whole-genome sequencing (WGS) used to predict susceptibility to ciprofloxacin and other antimicrobials using a global collection of N. gonorrhoeae isolates.MethodsSusceptibility testing of common antimicrobials and the recently developed zolifodacin was performed using agar dilution to determine minimum inhibitory concentrations (MICs). We identified resistance alleles at loci known to contribute to antimicrobial resistance in N. gonorrhoeae from WGS data. We tested the ability of each locus to predict antimicrobial susceptibility.ResultsA total of 481 N. gonorrhoeae isolates, collected between 2004 and 2019 and making up 457 unique genomes, were sourced from 5 countries. All isolates with demonstrated susceptibility to ciprofloxacin (MIC ≤0.06 μg/mL) had a wild-type gyrA codon 91. Multilocus approaches were needed to predict susceptibility to other antimicrobials. All isolates were susceptible to zoliflodacin, defined by an MIC ≤0.25 μg/mL.ConclusionsSingle marker prediction can be used to inform ciprofloxacin treatment of N. gonorrhoeae infection. A combination of molecular markers may be needed to determine susceptibility for other antimicrobials.

Published
2023

6. WHO global research priorities for antimicrobial resistance in human health

Author

Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, Zignol, Matteo, Rudan, Igor, Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, and Weezenbeek, Kitty Van

Published
2024
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7. Resistance-Guided Treatment of Gonorrhea: A Prospective Clinical Study

Author

Klausner, Jeffrey D, Bristow, Claire C, Soge, Olusegun O, Shahkolahi, Akbar, Waymer, Toni, Bolan, Robert K, Philip, Susan S, Asbel, Lenore E, Taylor, Stephanie N, Mena, Leandro A, Goldstein, Deborah A, Powell, Jonathan A, Wierzbicki, Michael R, and Morris, Sheldon R

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Sexually Transmitted Infections, Clinical Trials and Supportive Activities, Clinical Research, Infectious Diseases, Antimicrobial Resistance, Emerging Infectious Diseases, Infection, Good Health and Well Being, Anti-Bacterial Agents, Ciprofloxacin, Drug Resistance, Bacterial, Gonorrhea, Humans, Microbial Sensitivity Tests, Neisseria gonorrhoeae, Prospective Studies, ciprofloxacin, antimicrobial resistance, serine 91, gyrase A gene, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

BackgroundNovel treatment strategies to slow the continued emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae are urgently needed. A molecular assay that predicts in vitro ciprofloxacin susceptibility is now available but has not been systematically studied in human infections.MethodsUsing a genotypic polymerase chain reaction assay to determine the status of the N. gonorrhoeae gyrase subunit A serine 91 codon, we conducted a multisite prospective clinical study of the efficacy of a single oral dose of ciprofloxacin 500 mg in patients with culture-positive gonorrhea. Follow-up specimens for culture were collected to determine microbiological cure 5-10 days post-treatment.ResultsOf the 106 subjects possessing culture-positive infections with wild-type gyrA serine N. gonorrhoeae genotype, the efficacy of single-dose oral ciprofloxacin treatment in the per-protocol population was 100% (95% 1-sided confidence interval, 97.5-100%).ConclusionsResistance-guided treatment of N. gonorrhoeae infections with single-dose oral ciprofloxacin was highly efficacious. The widespread introduction and scale-up of gyrA serine 91 genotyping in N. gonorrhoeae infections could have substantial medical and public health benefits in settings where the majority of gonococcal infections are ciprofloxacin susceptible.Clinical trials registrationNCT02961751.

Published
2021

8. Near-Universal Resistance to Macrolides of Treponema pallidum in North America

Author

Lieberman, Nicole A.P., primary, Reid, Tara B., additional, Cannon, Chase A., additional, Nunley, B. Ethan, additional, Berzkalns, Anna, additional, Cohen, Stephanie E., additional, Newman, Lori M., additional, Aldrete, Sol, additional, Xu, Linda H., additional, Thornlund, Clinton P., additional, Pettus, Kevin, additional, Lundy, Stephanie, additional, Kron, Michael, additional, Soge, Olusegun O., additional, Workowski, Kimberly, additional, Perlowski, Charlotte, additional, Hook, Edward W., additional, Dionne, Jodie A., additional, Golden, Matthew R., additional, Lieberman, Joshua A., additional, Lee, Min-Kuang, additional, Morshed, Muhammad, additional, Naidu, Prenilla, additional, Cao, Weiping, additional, Pillay, Allan, additional, Giacani, Lorenzo, additional, and Greninger, Alexander L., additional

Published
2024
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10. Doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections among Kenyan women using HIV pre-exposure prophylaxis: study protocol for an open-label randomized trial

Author

Stewart, Jenell, Bukusi, Elizabeth, Sesay, Fredericka A., Oware, Kevin, Donnell, Deborah, Soge, Olusegun O., Celum, Connie, Odoyo, Josephine, Kwena, Zachary A., Scoville, Caitlin W., Violette, Lauren R., Morrison, Susan, Simoni, Jane, McClelland, R. Scott, Barnabas, Ruanne, Gandhi, Monica, and Baeten, Jared M.

Published
2022
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13. Strengthening a collaborative approach to implementing surveillance systems: Lessons from the Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP) in Malawi and Zimbabwe

Author

Vumbugwa, Phiona, primary, Maatouk, Ismael, additional, Machiha, Anna, additional, Matoga, Mitch, additional, Mitambo, Collins, additional, Nyirenda, Rose, additional, Nyasulu, Ishmael, additional, Mugabe, Muchaneta, additional, Ngwenya, Mkhokheli, additional, Mundade, Yamuna, additional, Wi, Teodora, additional, Unemo, Magnus, additional, and Soge, Olusegun O., additional

Published
2024
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14. Leveraging Health Information System Maturity Assessments to Guide Strategic Priorities: Perspectives from African Leaders

Author

Vumbugwa, Phiona, primary, Puttkammer, Nancy, additional, Majaha, Moira, additional, Stampfly, Sonora, additional, Biondich, Paul, additional, Shivers, Jennifer Ellen, additional, Mburu, Kendi, additional, Soge, Olusegun O., additional, Longenecker, Chris, additional, Flowers, Jan, additional, and Feldacker, Caryl, additional

Published
2024
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15. β-Lactamase and Macrolide Resistance Gene Carriage in Escherichia coli Isolates Among Children Discharged From Inpatient Care in Western Kenya: A Cross-sectional Study.

Author

Mogeni, Polycarp, Soge, Olusegun O, Tickell, Kirkby D, Tornberg, Stephanie N, Pascual, Rushlenne, Wakatake, Erika, Diakhate, Mame M, Rwigi, Doreen, Kariuki, Kevin, Kariuki, Samuel, Singa, Benson O, Fang, Ferric C, Walson, Judd L, and Pavlinac, Patricia B

Subjects
*INPATIENT care, *ESCHERICHIA coli, *HOSPITAL admission & discharge, *HEALTH facilities, *MEASLES vaccines
Abstract

Background Antimicrobial resistance (AMR) is a global threat to infectious disease control, particularly among recently hospitalized children. We sought to determine the prevalence and mitigating factors of resistance in enteric Escherichia coli among children discharged from health facilities in western Kenya. Methods Between June 2016 and November 2019, children aged 1 to 59 months were enrolled at the point of discharge from the hospital. E coli was isolated by microbiological culture from rectal swabs at baseline. β-Lactamases and macrolide resistance–conferring genes were detected by polymerase chain reaction. A modified Poisson regression model was used to assess the predictors mph (A) and CTX-M–type extended-spectrum β-lactamase (ESBL). Results Of the 238 children whose E coli isolates were tested, 91 (38.2%) and 109 (45.8%) had detectable CTX-M–type ESBL and mph (A) genes, respectively. Antibiotic treatment during hospitalization (adjusted prevalence ratio [aPR], 2.47; 95% CI, 1.12–5.43; P =.025), length of hospitalization (aPR, 1.42; 95% CI, 1.00–2.01; P =.052), and the practice of open defecation (aPR, 2.47; 95% CI, 1.40–4.36; P =.002) were independent predictors for CTX-M–type ESBL and mph (A) genes. Pneumococcal vaccination was associated with a 43% lower likelihood of CTX-M–type ESBL (aPR, 0.57; 95% CI,.38–.85; P =.005), while measles vaccination was associated with a 32% lower likelihood of mph (A) genes (aPR, 0.68; 95% CI,.49–.93; P =.017) in E coli isolates. Conclusions Among children discharged from the hospital, history of vaccination, shorter hospital stay, lack of in-hospital antibiotic exposure, and improved sanitation were associated with a lower likelihood of AMR genes. To mitigate the continued spread of AMR, AMR control programs should consider strategies beyond antimicrobial stewardship, including improvements in sanitation, increased vaccine coverage, and the development of novel vaccines. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Doxycycline Prophylaxis to Prevent Sexually Transmitted Infections in Women

Author

Stewart, Jenell, primary, Oware, Kevin, additional, Donnell, Deborah, additional, Violette, Lauren R., additional, Odoyo, Josephine, additional, Soge, Olusegun O., additional, Scoville, Caitlin W., additional, Omollo, Victor, additional, Mogaka, Felix O., additional, Sesay, Fredericka A., additional, McClelland, R. Scott, additional, Spinelli, Matthew, additional, Gandhi, Monica, additional, Bukusi, Elizabeth A., additional, and Baeten, Jared M., additional

Published
2023
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17. Genomic Epidemiology of Treponema pallidum and Circulation of Strains With Diminished tprK Antigen Variation Capability in Seattle, 2021–2022.

Author

Lieberman, Nicole A P, Avendaño, Carlos C, Bakhash, Shah A K Mohamed, Nunley, Ethan, Xie, Hong, Giacani, Lorenzo, Berzkalns, Anna, Soge, Olusegun O, Reid, Tara B, Golden, Matthew R, and Greninger, Alexander L

Abstract

Background The incidence of syphilis continues to increase in the United States, yet little is known about Treponema pallidum genomic epidemiology within American metropolitan areas. Methods We performed whole-genome sequencing and tprK deep sequencing of 28 T. pallidum– containing specimens, collected mostly from remnant Aptima swab specimens from 24 individuals from Seattle Sexual Health Clinic during 2021–2022. Results All 12 individuals infected with Nichols-lineage strains were men who have sex with men, while a specific SS14 cluster (mean, 0.33 single-nucleotide variant) included 1 man who has sex with women and 5 women. All T. pallidum strains sequenced were azithromycin resistant via 23S ribosomal RNA A2058G mutation. Identical T. pallidum genomic sequences were found in pharyngeal and rectal swab specimens taken concurrently from the same individuals. The tprK sequences were less variable between patient-matched specimens and between epidemiologically linked clusters. We detected a 528–base pair deletion in the tprK donor site locus, eliminating 9 donor sites, in T. pallidum genomes of 3 individuals with secondary syphilis, associated with diminution of TprK diversity. Conclusions We developed an end-to-end workflow for public health genomic surveillance of T. pallidum from remnant Aptima swab specimens. tprK sequencing may assist in linking cases beyond routine T. pallidum genome sequencing. T. pallidum strains with deletions in tprK donor sites currently circulate and are associated with diminished TprK antigenic diversity. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Genomic Epidemiology of Treponema pallidum and Circulation of Strains With Diminished tprK Antigen Variation Capability in Seattle, 2021–2022

Author

Lieberman, Nicole A P, primary, Avendaño, Carlos C, additional, Bakhash, Shah A K Mohamed, additional, Nunley, Ethan, additional, Xie, Hong, additional, Giacani, Lorenzo, additional, Berzkalns, Anna, additional, Soge, Olusegun O, additional, Reid, Tara B, additional, Golden, Matthew R, additional, and Greninger, Alexander L, additional

Published
2023
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25. Genomic epidemiology of Treponema pallidum and circulation of strains with diminished tprK antigen variation capability in Seattle, 2021-2022

Author

Lieberman, Nicole AP, primary, Avendano, Carlos, additional, Mohamed Bakhash, Shah AK, additional, Nunley, Ethan, additional, Xie, Hong, additional, Giacani, Lorenzo, additional, Berzkalns, Anna, additional, Soge, Olusegun O, additional, Reid, Tara B, additional, Golden, Matthew R, additional, and Greninger, Alexander L, additional

Published
2023
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27. Mycoplasma genitalium in the US (MyGeniUS): Surveillance Data From Sexual Health Clinics in 4 US Regions.

Author

Manhart, Lisa E, Leipertz, Gina, Soge, Olusegun O, Jordan, Stephen J, McNeil, Candice, Pathela, Preeti, Reno, Hilary, Wendel, Karen, Parker, Anika, Geisler, William M, Getman, Damon, Golden, Matthew R, and Team, for the MyGeniUS Study

Subjects
PUBLIC health surveillance, MYCOPLASMA diseases, CONFIDENCE intervals, CLINICS, DESCRIPTIVE statistics, DRUG resistance in microorganisms, DATA analysis software, SEXUAL health
Abstract

Background Mycoplasma genitalium (MG) is on the CDC Watch List of Antimicrobial Resistance Threats, yet there is no systematic surveillance to monitor change. Methods We initiated surveillance in sexual health clinics in 6 cities, selecting a quota sample of urogenital specimens tested for gonorrhea and/or chlamydia. We abstracted patient data from medical records and detected MG and macrolide-resistance mutations (MRMs) by nucleic acid amplification testing. We used Poisson regression to estimate adjusted prevalence ratios (aPRs) and 95% CIs, adjusting for sampling criteria (site, birth sex, symptom status). Results From October–December 2020 we tested 1743 urogenital specimens: 57.0% from males, 46.1% from non-Hispanic Black persons, and 43.8% from symptomatic patients. MG prevalence was 16.6% (95% CI: 14.9–18.5%; site-specific range: 9.9–23.5%) and higher in St Louis (aPR: 1.9; 1.27–2.85), Greensboro (aPR: 1.8; 1.18–2.79), and Denver (aPR: 1.7; 1.12–2.44) than Seattle. Prevalence was highest in persons <18 years (30.4%) and declined 3% per each additional year of age (aPR:.97;.955–.982). MG was detected in 26.8%, 21.1%, 11.8%, and 15.4% of urethritis, vaginitis, cervicitis, and pelvic inflammatory disease (PID), respectively. It was present in 9% of asymptomatic males and 15.4% of asymptomatic females, and associated with male urethritis (aPR: 1.7; 1.22–2.50) and chlamydia (aPR: 1.7; 1.13–2.53). MRM prevalence was 59.1% (95% CI: 53.1–64.8%; site-specific range: 51.3–70.6%). MRMs were associated with vaginitis (aPR: 1.8; 1.14–2.85), cervicitis (aPR: 3.5; 1.69–7.30), and PID cervicitis (aPR: 1.8; 1.09–3.08). Conclusions MG infection is common in persons at high risk of sexually transmitted infections; testing symptomatic patients would facilitate appropriate therapy. Macrolide resistance is high and azithromycin should not be used without resistance testing. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections

Author

Luetkemeyer, Anne F., primary, Donnell, Deborah, additional, Dombrowski, Julia C., additional, Cohen, Stephanie, additional, Grabow, Cole, additional, Brown, Clare E., additional, Malinski, Cheryl, additional, Perkins, Rodney, additional, Nasser, Melody, additional, Lopez, Carolina, additional, Vittinghoff, Eric, additional, Buchbinder, Susan P., additional, Scott, Hyman, additional, Charlebois, Edwin D., additional, Havlir, Diane V., additional, Soge, Olusegun O., additional, and Celum, Connie, additional

Published
2023
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33. Multiple PMQR genes including the rare qepA detected in Ciprofloxacin non-susceptible Escherichia coli and Klebsiella isolated from children under five years at hospital discharge, Kenya.

Author

Kariuki, Kevin, primary, Diakhate, Mame Mareme, additional, Musembi, Susan, additional, Tornberg-Belanger, Stephanie N., additional, Rwigi, Doreen, additional, Mutuma, Timothy, additional, Mutuku, Elizabeth, additional, Tickell, Kirkby D., additional, Soge, Olusegun O., additional, Singa, Benson O., additional, Walson, Judd L., additional, Pavlinac, Patricia B., additional, and Kariuki, Samuel, additional

Published
2023
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34. Antimicrobial Drug Prescription and Neisseria gonorrhoeae Susceptibility, United States, 2005-2013

Author

Kirkcaldy, Robert D., Bartoces, Monina G., Soge, Olusegun O., Riedel, Stefan, Kubin, Grace, Del Rio, Carlos, Papp, John R., Hook, Edward W., III, and Hicks, Lauri A.

Subjects
Microbial drug resistance -- Forecasts and trends, Neisseria gonorrhoeae -- Health aspects, Market trend/market analysis, Health
Abstract

Neisseria gonorrhoeae, the causative pathogen of gonorrhea, has been designated an urgent antimicrobial drug resistance threat by the Centers for Disease Control and Prevention (CDC) (1). Since the introduction of [...]

Published
2017
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36. Additional file 1 of Plasmid-mediated quinolone resistance genes detected in Ciprofloxacin non-susceptible Escherichia coli and Klebsiella isolated from children under five years at hospital discharge, Kenya

Author

Kariuki, Kevin, Diakhate, Mame Mareme, Musembi, Susan, Tornberg-Belanger, Stephanie N., Rwigi, Doreen, Mutuma, Timothy, Mutuku, Elizabeth, Tickell, Kirkby D., Soge, Olusegun O., Singa, Benson O., Walson, Judd L., Pavlinac, Patricia B., and Kariuki, Samuel

Abstract

Additional file 1: Table S1. Correlates of non-susceptibility to Ciprofloxacin.

Published
2023
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37. Additional file 2 of Plasmid-mediated quinolone resistance genes detected in Ciprofloxacin non-susceptible Escherichia coli and Klebsiella isolated from children under five years at hospital discharge, Kenya

Author

Kariuki, Kevin, Diakhate, Mame Mareme, Musembi, Susan, Tornberg-Belanger, Stephanie N., Rwigi, Doreen, Mutuma, Timothy, Mutuku, Elizabeth, Tickell, Kirkby D., Soge, Olusegun O., Singa, Benson O., Walson, Judd L., Pavlinac, Patricia B., and Kariuki, Samuel

Abstract

Additional file 2: Table S2. List of the PCR primer pairs and expected PCR product sizes.

Published
2023
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40. Prior Exposure to Azithromycin and Azithromycin Resistance Among Persons Diagnosed With Neisseria gonorrhoeae Infection at a Sexual Health Clinic: 2012–2019

Author

Rowlinson, Emily, primary, Soge, Olusegun O, additional, Hughes, James P, additional, Berzkalns, Anna, additional, Thibault, Christina, additional, Kerani, Roxanne P, additional, Khosropour, Christine M, additional, Manhart, Lisa E, additional, Golden, Matthew R, additional, and Barbee, Lindley A, additional

Published
2022
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41. Doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections among Kenyan women using HIV pre-exposure prophylaxis: study protocol for an open label randomized trial

Author

Stewart, Jenell, primary, Bukusi, Elizabeth, additional, Sesay, Fredericka A, additional, Oware, Kevin, additional, Donnell, Deborah, additional, Soge, Olusegun O, additional, Celum, Connie, additional, Odoyo, Josephine, additional, Kwena, Zachary, additional, Scoville, Caitlin W., additional, Violette, Lauren R, additional, Morrison, Susan, additional, Simoni, Jane, additional, McClelland, R. Scott, additional, Barnabas, Ruanne, additional, Gandhi, Monica, additional, and Baeten, Jared M, additional

Published
2022
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42. Summary of the Fourth Annual American Sexually Transmitted Diseases Association Workshop on Improving Sexually Transmitted Infection Control Efforts Through Cross-Sector Collaboration

Author

Van Gerwen, Olivia, primary, Griner, Stacey, additional, Davis, Alissa, additional, Footman, Alison, additional, Pinto, Casey N., additional, Melendez, Johan H., additional, Tuddenham, Susan, additional, Exten, Cara, additional, Soge, Olusegun O., additional, Chakraborty, Payal, additional, Nenninger, Ashley, additional, Marlowe, Elizabeth M., additional, Joseph, Ajith M., additional, McGowin, Chris L., additional, Seña, Arlene C., additional, Fortenberry, J. Dennis, additional, Ghanem, Khalil G., additional, and Van Der Pol, Barbara, additional

Published
2022
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46. Prior Exposure to Azithromycin and Azithromycin Resistance Among Persons Diagnosed With Neisseria gonorrhoeae Infection at a Sexual Health Clinic: 2012–2019.

Author

Rowlinson, Emily, Soge, Olusegun O, Hughes, James P, Berzkalns, Anna, Thibault, Christina, Kerani, Roxanne P, Khosropour, Christine M, Manhart, Lisa E, Golden, Matthew R, and Barbee, Lindley A

Subjects
*GONORRHEA, *CONFIDENCE intervals, *MULTIPLE regression analysis, *TIME, *CLINICS, *REGRESSION analysis, *DISEASE susceptibility, *SYMPTOMS, *RESEARCH funding, *AZITHROMYCIN, *DRUG resistance in microorganisms, *ODDS ratio, *SEXUAL health
Abstract

Background There is conflicting evidence on whether prior azithromycin (AZM) exposure is associated with reduced susceptibility to AZM (AZMRS) among persons infected with Neisseria gonorrhoeae (NG). Methods The study population included Public Health–Seattle and King County Sexual Health Clinic (SHC) patients with culture-positive NG infection at ≥1 anatomic site whose isolates were tested for AZM susceptibility in 2012–2019. We used multivariate logistic regression to examine the association of time since last AZM prescription from the SHC in ≤12 months with subsequent diagnosis with AZMRS NG (minimum inhibitory concentration [MIC], ≥2.0 µg/mL) and used linear regression to assess the association between the number of AZM prescriptions in ≤12 months and AZM MIC level, controlling for demographic, behavioral, and clinical characteristics. Results A total of 2155 unique patients had 2828 incident NG infections, 156 (6%) of which were caused by AZMRS NG. AZMRS NG was strongly associated with receipt of AZM from the SHC in the prior 29 days (adjusted odds ratio, 6.76; 95% confidence interval [CI], 1.76 to 25.90) but not with receipt of AZM in the prior 30–365 days. Log AZM MIC level was not associated with the number of AZM prescriptions within ≤12 months (adjusted correlation, 0.0004; 95% CI, –.04 to.037) but was associated with number of prescriptions within <30 days (adjusted coefficient, 0.56; 95% CI,.13 to.98). Conclusions Recent individual-level AZM treatment is associated with subsequent AZMRS gonococcal infections. The long half-life and persistence of subtherapeutic levels of AZM may result in selection of resistant NG strains in persons with recent AZM use. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Antimicrobial resistance including Extended Spectrum Beta Lactamases (ESBL) among E. coli isolated from kenyan children at hospital discharge

Author

Tornberg-Belanger, Stephanie N., primary, Rwigi, Doreen, additional, Mugo, Michael, additional, Kitheka, Lynnete, additional, Onamu, Nancy, additional, Ounga, Derrick, additional, Diakhate, Mame M., additional, Atlas, Hannah E., additional, Wald, Anna, additional, McClelland, R. Scott, additional, Soge, Olusegun O., additional, Tickell, Kirkby D., additional, Kariuki, Samuel, additional, Singa, Benson O., additional, Walson, Judd L., additional, and Pavlinac, Patricia B., additional

Published
2022
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49. Azithromycin resistance and decreased ceftriaxone susceptibility in Neisseria gonorrhoeae, Hawaii, USA

Author

Papp, John R., Abrams, A. Jeanine, Nash, Evelyn, Katz, Alan R., Kirkcaldy, Robert D., O'Connor, Norman P., O'Brien, Pamela S., Harauchi, Derek H., Maningas, Eloisa V., Soge, Olusegun O., Kersh, Ellen N., Komeya, Alan, Tomas, Juval E., Wasserman, Glenn M., Kunimoto, Gail Y., Trees, David L., and Whelen, A. Christian

Subjects
United States. Centers for Disease Control and Prevention -- Analysis, Sexually transmitted diseases -- Analysis -- Health aspects, Azithromycin -- Analysis -- Health aspects, Disease transmission -- Analysis -- Health aspects, Phylogeny -- Analysis -- Health aspects, Health
Abstract

Nisseria gonorrhoeae is a sexually transmitted pathogen that has progressively developed resistance to the antimicrobial agents recommended for treatment (1). Third-generation cephalosporins are among the last class of antimicrobial agents [...]

Published
2017
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