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16 results on '"Sogame, Ryosuke"'

2. Clinical and immunological profiles of anti-BP230-type bullous pemphigoid: Restriction of epitopes to the C-terminal domain of BP230, shown by novel ELISAs of BP230-domain specific recombinant proteins

Author

Hayakawa, Taihei, Teye, Kwesi, Hachiya, Takahisa, Uehara, Rie, Hashiguchi, Masahiro, Kawakami, Tamihiro, Li, Xiaoguang, Tsuchisaka, Atsunari, Ohara, Koji, Sogame, Ryosuke, Koga, Hiroshi, Hamada, Takahiro, Ohata, Chika, Furumura, Minao, Ishii, Norito, Fukano, Hideo, Shimozato, Kazuo, and Hashimoto, Takashi

Published
2016
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6. Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy

Author

Ichimura, Yuki, Matsushita, Takashi, Hamaguchi, Yasuhito, Kaji, Kenzo, Hasegawa, Minoru, Tanino, Yoshinori, Inokoshi, Yayoi, Kawai, Kazuhiro, Kanekura, Takuro, Habuchi, Maria, Igarashi, Atsuyuki, Sogame, Ryosuke, Hashimoto, Takashi, Koga, Tomohiro, Nishino, Ayako, Ishiguro, Naoko, Sugimoto, Naoki, Aoki, Rui, Ando, Noriko, Abe, Tetsuya, Kanda, Takashi, Kuwana, Masataka, Takehara, Kazuhiko, and Fujimoto, Manabu

Published
2012
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8. Integrin ß4 is a major target antigen in pure ocular mucous membrane pemphigoid

Author

Li, Xiaoguang, additional, Qian, Hua, additional, Sogame, Ryosuke, additional, Hirako, Yoshiaki, additional, Tsuruta, Daisuke, additional, Ishii, Norito, additional, Koga, Hiroshi, additional, Tsuchisaka, Atsunari, additional, Jin, Zhexiong, additional, Tsubota, Kazuo, additional, Fukumoto, Akiko, additional, Sotozono, Chie, additional, Kinoshita, Shigeru, additional, and Hashimoto, Takashi, additional

Published
2016
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9. Epiplakin Is a Paraneoplastic Pemphigus Autoantigen and Related to Bronchiolitis Obliterans in Japanese Patients

Author

Tsuchisaka, Atsunari, primary, Numata, Sanae, additional, Teye, Kwesi, additional, Natsuaki, Yohei, additional, Kawakami, Tamihiro, additional, Takeda, Yoshito, additional, Wang, Wenqing, additional, Ishikawa, Kazushi, additional, Goto, Mizuki, additional, Koga, Hiroshi, additional, Sogame, Ryosuke, additional, Ishii, Norito, additional, Takamori, Shinzo, additional, Hoshino, Tomoaki, additional, Brandt, Oliver, additional, Pas, Hendri H., additional, Fujiwara, Sakuhei, additional, and Hashimoto, Takashi, additional

Published
2016
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10. Immunological and Statistical Studies of Anti-BP180 Antibodies in Paraneoplastic Pemphigus

Author

Tsuchisaka, Atsunari, primary, Kawano, Hideo, additional, Yasukochi, Atsushi, additional, Teye, Kwesi, additional, Ishii, Norito, additional, Koga, Hiroshi, additional, Sogame, Ryosuke, additional, Ohzono, Ayaka, additional, Krol, Rafal P., additional, Kawakami, Tamihiro, additional, Furumura, Minao, additional, Ohata, Chika, additional, Li, Xiaoguang, additional, and Hashimoto, Takashi, additional

Published
2014
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11. Anti-Alpha-2-Macroglobulin-Like-1 Autoantibodies Are Detected Frequently and May Be Pathogenic in Paraneoplastic Pemphigus

Author

Numata, Sanae, primary, Teye, Kwesi, additional, Tsuruta, Daisuke, additional, Sogame, Ryosuke, additional, Ishii, Norito, additional, Koga, Hiroshi, additional, Natsuaki, Yohei, additional, Tsuchisaka, Atsunari, additional, Hamada, Takahiro, additional, Karashima, Tadashi, additional, Nakama, Takekuni, additional, Furumura, Minao, additional, Ohata, Chika, additional, Kawakami, Tamihiro, additional, Schepens, Isabelle, additional, Borradori, Luca, additional, and Hashimoto, Takashi, additional

Published
2013
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13. Decline of disease activity and autoantibodies to desmoglein 3 and envoplakin by oral prednisolone in paraneoplastic pemphigus with benign thymoma

Author

Ishii, Norito, additional, Hamada, Takahiro, additional, Koga, Hiroshi, additional, Sogame, Ryosuke, additional, Ohyama, Bungo, additional, Fukuda, Shunpei, additional, Natsuaki, Yohei, additional, Dainichi, Teruki, additional, Karashima, Tadashi, additional, Nakama, Takekuni, additional, Tsuruta, Daisuke, additional, and Hashimoto, Takashi, additional

Published
2012
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14. Interaction of plectin and intermediate filaments

Author

Karashima, Tadashi, primary, Tsuruta, Daisuke, additional, Hamada, Takahiro, additional, Ishii, Norito, additional, Ono, Fumitake, additional, Hashikawa, Keiko, additional, Ohyama, Bungo, additional, Natsuaki, Yohei, additional, Fukuda, Shunpei, additional, Koga, Hiroshi, additional, Sogame, Ryosuke, additional, Nakama, Takekuni, additional, Dainichi, Teruki, additional, and Hashimoto, Takashi, additional

Published
2012
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16. Anti-α-2-macroglobulin-like-1 autoantibodies are detected frequently and may be pathogenic in paraneoplastic pemphigus.

Author

Numata S, Teye K, Tsuruta D, Sogame R, Ishii N, Koga H, Natsuaki Y, Tsuchisaka A, Hamada T, Karashima T, Nakama T, Furumura M, Ohata C, Kawakami T, Schepens I, Borradori L, and Hashimoto T

Subjects
Adolescent, Adult, Aged, Animals, Autoantibodies blood, Autoantibodies pharmacology, COS Cells, Cell Adhesion drug effects, Cells, Cultured, Child, Chlorocebus aethiops, Disease Models, Animal, Fibrinolysin metabolism, Fluorescent Antibody Technique, Humans, Immunoprecipitation, Keratinocytes drug effects, Keratinocytes metabolism, Keratinocytes pathology, Middle Aged, Rats, Transfection, Young Adult, alpha-Macroglobulins genetics, Autoantibodies physiology, Paraneoplastic Syndromes etiology, Paraneoplastic Syndromes physiopathology, Pemphigus etiology, Pemphigus physiopathology, alpha-Macroglobulins immunology
Abstract

Paraneoplastic pemphigus (PNP) shows autoantibodies mainly to plakin and desmosomal cadherin family proteins. We have recently identified alpha-2-macroglobulin-like-1 (A2ML1), a broad range protease inhibitor, as a unique PNP antigen. In this study, we tested a large number of PNP sera by various methods. Forty (69.0%) of 58 PNP sera recognized A2ML1 recombinant protein expressed in COS7 cells by immunofluorescence (IF) and/or immunoprecipitation (IP)/immunoblotting (IB). IP/IB showed higher sensitivity than IF. In addition, 22 (37.9%) PNP sera reacted with A2ML1 by IB of cultured normal human keratinocytes (NHKs) under non-reducing conditions. Statistical analyses using various clinical and immunological data showed that the presence of anti-A2ML1 autoantibodies was associated with early disease onset and absence of ocular lesions. Next, to investigate the pathogenic role of anti-A2ML1 antibody, we performed additional functional studies. Addition of anti-A2ML1 polyclonal antibody to culture media decreased NHK cell adhesion examined by dissociation assay, and increased plasmin activity detected by casein zymography, suggesting that anti-A2ML1 antibody may decrease NHK cell adhesion through plasmin activation by inhibition of A2ML1. This study demonstrates that autoantibodies to A2ML1 are frequently and specifically detected and may have a pathogenic role in PNP.

Published
2013
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