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19 results on '"Soffler, Carl"'

2. Efficacy of therapeutically administered gepotidacin in a rabbit model of inhalational anthrax

Author

Hilliard, Jamese J., primary, Jakielaszek, Charles, additional, Mannino, Frank, additional, Hossain, Mohammad, additional, Qian, Lian, additional, Fishman, Cindy, additional, Demons, Samandra, additional, Hershfield, Jeremy, additional, Soffler, Carl, additional, Russo, Riccardo, additional, Henning, Lisa, additional, Novak, Joseph, additional, and O'Dwyer, Karen, additional

Published
2024
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3. Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei

Author

Amemiya, Kei, Dankmeyer, Jennifer L., Bearss, Jeremy J., Zeng, Xiankun, Stonier, Spencer W., Soffler, Carl, Cote, Christopher K., Welkos, Susan L., Fetterer, David P., Chance, Taylor B., Trevino, Sylvia R., Worsham, Patricia L., and Waag, David M.

Published
2020
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6. Additional file 3 of Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei

Author

Amemiya, Kei, Dankmeyer, Jennifer, Bearss, Jeremy, Xiankun Zeng, Stonier, Spencer, Soffler, Carl, Cote, Christopher, Welkos, Susan, Fetterer, David, Chance, Taylor, Trevino, Sylvia, Worsham, Patricia, and Waag, David

Abstract

Additional file 3 Figure S2. Intracellular expression of TNF-α and IFN-γ in infected spleen cells from B. pseudomallei exposed mice. The data are representative of 49 spleens from B. pseudomallei (includes 8 different strains) exposed mice and 10 naïve mice that were determined at least once. The aerosol 21 day LD50 studies of some B. pseudomallei strains were evaluated more than once. Examples of the intracellular expression of TNF-α in different cell types is shown in Figure S2A. Cytometric analysis of spleens from a naïve mouse (panel 1), two infected spleens from mice exposed to 7007 CFU of B. pseudomallei 1106a 50 days PI (panel 2), two spleens from mice exposed to ~ 1 CFU of B. pseudomallei MSHR5855 26 days PI, one normal appearing and one infected spleen (panel 3), and two spleens from mice exposed to 2 CFU of B. pseudomallei 1026b 30 days PI, one swollen and one infected (panel 4). The intracellular expression of IFN-γ in the same spleen cells is shown in Figure S2B. The intracellular expression of TNF-α and IFN-γ was examined in CD4+/CD44+ and CD8+/CD44+ T Cells, B cells (B220+/CD86+), monocyte/macrophages (CD11b+/CD44+), NK cells (CD49b+/CD44+), and granulocytes (Ly6G+/CD44+). The gating for the percentage of cells with intracellular cytokine expression was established with isotype or single stained controls or against naïve mice. Note the greater changes in the % monocyte/macrophages, % NK cells, and % granulocytes population in the cells from infected spleens.

Published
2020
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7. Additional file 1 of Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei

Author

Amemiya, Kei, Dankmeyer, Jennifer, Bearss, Jeremy, Xiankun Zeng, Stonier, Spencer, Soffler, Carl, Cote, Christopher, Welkos, Susan, Fetterer, David, Chance, Taylor, Trevino, Sylvia, Worsham, Patricia, and Waag, David

Abstract

Additional file 1 Figure S1. Schematic of analysis of chronically infected BALB/c mice. Processing of mouse samples for analysis of chronic infection.

Published
2020
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8. Comparative virulence of three different strains of Burkholderia pseudomallei in an aerosol non-human primate model

Author

Trevino, Sylvia R., primary, Dankmeyer, Jennifer L., additional, Fetterer, David P., additional, Klimko, Christopher P., additional, Raymond, Jo Lynne W., additional, Moreau, Alicia M., additional, Soffler, Carl, additional, Waag, David M., additional, Worsham, Patricia L., additional, Amemiya, Kei, additional, Ruiz, Sara I., additional, Cote, Christopher K., additional, and Krakauer, Teresa, additional

Published
2021
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9. The Impact of Age and Sex on Mouse Models of Melioidosis

Author

Klimko, Christopher P., primary, Treviño, Sylvia R., additional, Moreau, Alicia M., additional, Aponte Cuadrado, Michael J., additional, Meyer, Joshua R., additional, Fetterer, David P., additional, Welkos, Susan L., additional, Worsham, Patricia L., additional, Kreiselmeier, Norman, additional, Soffler, Carl, additional, and Cote, Christopher K., additional

Published
2020
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10. Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure

Author

Yi, Jinhee, primary, Simpanya, Mukoma F., additional, Settles, Erik W., additional, Shannon, Austin B., additional, Hernandez, Karen, additional, Pristo, Lauren, additional, Keener, Mitchell E., additional, Hornstra, Heidie, additional, Busch, Joseph D., additional, Soffler, Carl, additional, Brett, Paul J., additional, Currie, Bart J., additional, Bowen, Richard A., additional, Tuanyok, Apichai, additional, and Keim, Paul, additional

Published
2019
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11. Disease progression in mice exposed to low-doses of aerosolized clinical isolates of Burkholderia pseudomallei

Author

Trevino, Sylvia R., primary, Klimko, Christopher P., additional, Reed, Matthew C., additional, Aponte-Cuadrado, Michael J., additional, Hunter, Melissa, additional, Shoe, Jennifer L., additional, Meyer, Joshua R., additional, Dankmeyer, Jennifer L., additional, Biryukov, Sergei S., additional, Quirk, Avery V., additional, Fritts, Kristen A., additional, Kern, Steven J., additional, Fetterer, David P., additional, Kohler, Lara J., additional, Toothman, Ronald G., additional, Bozue, Joel A., additional, Schellhase, Christopher W., additional, Kreiselmeier, Norman, additional, Daye, Sharon P., additional, Welkos, Susan L., additional, Soffler, Carl, additional, Worsham, Patricia L., additional, Waag, David M., additional, Amemiya, Kei, additional, and Cote, Christopher K., additional

Published
2018
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12. Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure

Author

Yi, Jinhee, primary, Simpanya, Mukoma F., additional, Settles, Erik W., additional, Shannon, Austin B., additional, Hernandez, Karen, additional, Pristo, Lauren, additional, Keener, Mitchell E., additional, Hornstra, Heidie, additional, Busch, Joseph D., additional, Soffler, Carl, additional, Brett, Paul J., additional, Currie, Bart J., additional, Bowen, Richard A., additional, Tuanyok, Apichai, additional, and Keim, Paul, additional

Published
2018
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19. Measurement of urinary F2-isoprostanes as markers of in vivo lipid peroxidation: a comparison of enzyme immunoassays with gas chromatography--mass spectrometry in domestic animal species.

Author

Soffler, Carl, Campbell, Vicki L., and Hassel, Diana M.

Subjects
ISOPROSTANES, PEROXIDATION, DOMESTIC animals, ENZYME-linked immunosorbent assay, GAS chromatography, MASS spectrometry
Abstract

The article discusses research on the difference between gas chromatography-mass spectrometry and enzyme immunoassays that are commonly used in examining the urinary isoprostanes markers in domestic animal species. It references a study by Carl Soffler and colleagues, published in the 2010 issue of the "Journal of Veterinary Diagnostic Investigation." The researchers evaluated the agreement in isoprostane kits that are commercially available. They found that the concentration of isoprostane is highly variable in animals that are critically ill.

Published
2010
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