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8. Recorded Lower Esophageal Pressures as a Function of Electronic Sleeve Placement and Location of Gastric Pressure Measurement in Patients With Hiatal Hernia

Author

Basseri, Benjamin, Pimentel, Mark, Chang, Christopher, Soffer, Edy E, and Conklin, Jeffrey L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Clinical Research, Catheters, Esophagus, Gastroesophageal reflux, Hernia, hiatal, Manometry, Medical Biochemistry and Metabolomics, Clinical sciences
Abstract

Background/aimsIn high-resolution manometry lower esophageal sphincter pressure (LESP) is measured relative to intragastric pressure, however Gastric Marker™ (GM) location used to determine resting LESP is not well established with hiatal hernia (HH). We test the hypothesis that measured resting LESP varies with HH based on GM location.MethodsSubjects with HH ≥ 2 cm were included. The eSleeve™ was adjusted to span only the LES, excluding the crural diaphragm (CD). Resting LESP was determined by placing the GM below and above the CD (in the position yielding the highest resting LESP). Resting pressure across the lower esophageal sphincter (LES) to CD and pressure in the HH relative to subdiaphragmatic intragastric pressure were also measured.ResultsHH ≥ 2 cm was present in 98 patients (mean length 2.7 cm). LESP decreased when GM was moved from below the CD into the HH: respiratory minimum LESP 7.5 ± 1.1 to 3.6 ± 0.9 mmHg; P < 0.001, mean LESP 17.7 ± 1.3 to 13.7 ± 1.1 mmHg; P < 0.001. When the eSleeve encompassed the LES and CD, the respiratory minimum pressure was 12.2 ± 0.9 mmHg and mean pressure was 23.9 ± 1.0 mmHg pressure (P < 0.001 for both). Pressure in the hernia pouch was greater than intragastric pressure: respiratory minimum 3.0 ± 0.7 mmHg and mean 9.0 ± 0.8 mmHg (P < 0.001 for both). pH studies showed a trend toward an association between abnormal distal esophagus acid exposure and lower resting LESP.ConclusionsGM placement in the HH produces lower resting LESPs. This may provide a more physiologic representation of LESP in HH.

Published
2013

9. Smoothelin expression in the gastrointestinal tract: implication in colonic inertia.

Author

Chan, Owen TM, Chiles, Lauren, Levy, Mary, Zhai, Jing, Yerian, Lisa M, Xu, Haodong, Xiao, Shu-Yuan, Soffer, Edy E, Conklin, Jeffrey L, Dhall, Deepti, Kahn, Melissa E, Balzer, Bonnie L, Amin, Mahul B, and Wang, Hanlin L

Subjects
Gastrointestinal Tract, Mucous Membrane, Myocytes, Smooth Muscle, Humans, Esophageal Motility Disorders, Constipation, Muscle Proteins, Cytoskeletal Proteins, Immunohistochemistry, Retrospective Studies, Muscle Contraction, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Child, Preschool, Female, Male, Young Adult, smoothelin, colonic inertia, intestinal motility disorder, chronic intestinal pseudo-obstruction, slow transit constipation, Pathology, Medical Physiology
Abstract

Colonic inertia is a frustrating motility disorder to patients, clinicians, and pathologists. The pathogenesis is largely unknown. The aims of this study were to: (1) characterize the expression of smoothelin, a novel smooth muscle-specific contractile protein expressed only by terminally differentiated smooth muscle cells, in the normal gastrointestinal (GI) tract; and (2) determine whether smoothelin is aberrantly expressed in patients with colonic inertia. A total of 57 resections of the normal GI tract (distal esophagus to left colon) were obtained from patients without GI motor dysfunction. Sixty-one colon resections were obtained from patients with a clinical diagnosis of colonic inertia. Smoothelin immunostaining was conducted on full-thickness tissue sections. In the nondysmotile controls, strong and diffuse cytoplasmic staining for smoothelin was observed in both the inner circular and outer longitudinal layers of the muscularis propria (MP) throughout the entire GI tract. The muscularis mucosae (MM) and muscular vessel walls were either completely negative or only patchily and weakly stained. The 1 exception to this pattern was observed in the distal esophagus, in which the MM was also diffusely and strongly stained. In cases with colonic inertia, a moderate to marked reduction of smoothelin immunoreactivity was observed in 15 of 61 (24.6%) colon resections, selectively seen in the outer layer of the MP. The data demonstrate that smoothelin is differentially expressed in the MP and MM of the normal GI tract and suggest that defective smoothelin expression may play a role in the pathogenesis of colonic inertia in a subset of patients.

Published
2013

11. Contributors

Author

Acker, Brent W., primary, Allen-Brady, Kristina, additional, Altamirano-Barrera, Alejandra, additional, Amieva-Balmori, Mercedes, additional, Avalos, Danny J., additional, Bak, Young-Tae, additional, Basilisco, Guido, additional, Bhagatwala, Jigar, additional, Cash, Brooks D., additional, Chanpong, Atchariya, additional, Chiarioni, Giuseppe, additional, Choi, Yoon Jin, additional, Chuah, Kee-Huat, additional, Conklin, Jeffrey L., additional, Corsetti, Maura, additional, Devanarayana, Niranga Manjuri, additional, Erdogan, Askin, additional, Fass, Ofer, additional, Ghoshal, Uday C., additional, Ghoshal, Ujjala, additional, Gibson, Peter R., additional, Gonlachanvit, Sutep, additional, Greenwood-Van Meerveld, Beverley, additional, Gunn, David, additional, Gwee, Kok-Ann, additional, Halmos, Emma P., additional, Hamade, Nour, additional, Hamdy, Shaheen, additional, Haque, Mohammad Majharul, additional, Hershman, Melissa, additional, Jana, Tanima, additional, Johnson, Anthony C., additional, Karyampudi, Arun, additional, Khan, Abraham, additional, Kilpatrick, Lisa A., additional, Kingsley, Michael, additional, Kuo, Braden, additional, Labus, Jennifer S., additional, Lawenko, Rona Marie, additional, Lee, Yeong Yeh, additional, Lee, Yuan-Kun, additional, Louwies, Tijs, additional, Ma, Zheng Feei, additional, Mahadeva, Sanjiv, additional, Makharia, Govind K., additional, Malik, Zubair, additional, Manley, Grace C.A., additional, Mayer, Emeran A., additional, McCallum, Richard W., additional, Moshiree, Baharak, additional, Nabi, Zaheer, additional, Nassri, Ammar, additional, Nyabanga, Custon, additional, Orock, Albert, additional, Ouyang, Ann, additional, Paik, Il J., additional, Parker, Colleen H., additional, Parkman, Henry P., additional, Patcharatrakul, Tanisa, additional, Pitisuttithum, Panyavee, additional, Popa, Stefan-Lucian, additional, Rahman, M. Masudur, additional, Rajindrajith, Shaman, additional, Rao, Satish S.C., additional, Razeghi, Sanam, additional, Reddy, D. Nageshwar, additional, Remes-Troche, José María, additional, Robles, Alejandro, additional, Roman, Sabine, additional, Sanders, Kenton M., additional, Sasegbon, Ayodele, additional, Schey, Ron, additional, Shahsavari, Dariush, additional, Sharma, Amol, additional, Sharma, Prateek, additional, Siah Tien-Ho, Kewin, additional, Singh, Prashant, additional, Smukalla, Scott, additional, Soffer, Edy E., additional, Soh Yu Sen, Alex, additional, Sperber, Ami D., additional, Su, Andrew, additional, Thapar, Nikhil, additional, van Tilburg, Miranda A.L., additional, Tillisch, Kirsten, additional, Tun, Gustinna, additional, Tuteja, Ashok K., additional, Vachhani, Herit, additional, Valdovinos-Díaz, Miguel A., additional, Vasant, Dipesh H., additional, Vélez, Christopher David, additional, Wilkinson-Smith, Victoria, additional, Xiang, Xuelian, additional, Yan, Yun, additional, Yuan, Tian, additional, and Zhang, Yongliang, additional

Published
2020
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12. Evaluation of peripapillary lymphocytosis and lymphocytic esophagitis in adult inflammatory bowel disease.

Author

Basseri, Benjamin, Vasiliauskas, Eric A, Chan, Owen, Wang, Hanlin L, Basseri, Robert J, Pimentel, Mark, Soffer, Edy, and Conklin, Jeffrey L

Subjects
Crohn’s disease, esophagitis, inflammatory bowel disease, lymphocytes, lymphocytic esophagitis, ulcerative colitis, Inflammatory Bowel Disease, Crohn's Disease, Digestive Diseases, Autoimmune Disease, Clinical Research, Oral and gastrointestinal, Gastroenterology & Hepatology
Abstract

Lymphocytic esophagitis (LE) is a newly described entity characterized histopathologically by peripapillary lymphocytosis (PL) without significant granulocytes (neutrophils and eosinophils). In an initial study, a significant portion of patients with LE had Crohn's disease (CD). A subsequent study revealed LE in one quarter of children with CD. The aim of this study was to test the hypothesis that LE is associated with adult inflammatory bowel disease (IBD) and assess the disease variables that link LE and IBD. Random esophageal biopsies from consecutive adults with CD, ulcerative colitis (UC), or indeterminate colitis (IC) were evaluated. The numbers of lymphocytes, eosinophils, and neutrophils were counted from 3 high-power fields (HPF) in each specimen. Four of 47 patients (8.5%; 3/30 CD, 1/15 UC, and 0/2 IC) had PL (esophageal biopsies with ≥50 lymphocytes/HPF; mean, 100.5±31.1/HPF). A significant number of granulocytes were seen in biopsies from 3 of the 4 patients with PL, leaving 1 who met criteria for LE (PL without significant granulocytes). PL was associated with a higher erythrocyte sedimentation rate (90.3±17.6 mm/hr vs 24.5±3.6 mm/hr; P

Published
2013

13. Contributors

Author

Abbas, Abbas E., primary, Adams, David B., additional, Aggarwal, Piyush, additional, Ahmed, Bestoun H., additional, Albanese, Craig, additional, Albert, Matthew R., additional, Ali, Abubaker, additional, Alicuben, Evan, additional, Allaix, Marco E., additional, Altman, Ashley, additional, Ando, Hisami, additional, Andolfi, Ciro, additional, Annamalai, Alagappan, additional, Asare, Elliot A., additional, Asti, Emanuele, additional, Auchincloss, Hugh G., additional, Babic, Benjamin, additional, Baker, Talia B., additional, Ball, Chad G., additional, Barbetta, Arianna, additional, Barlow, John M., additional, Barr, Justin, additional, Barreto, Juan Camilo, additional, Barry, Linda, additional, Beal, Eliza W., additional, Beard, Kristin Wilson, additional, Beck, David E., additional, Behrns, Kevin E., additional, Bellevue, Oliver C., additional, Bellorin-Marin, Omar E., additional, Bergman, Jacques, additional, Berry, James, additional, Besselink, Marc G.H., additional, Bharucha, Adil E., additional, Bilchik, Anton J., additional, Bildzukewicz, Nikolai A., additional, Bingham, Jason, additional, Birnbaum, Elisa, additional, Black, Sylvester M., additional, Blackmon, Shanda H., additional, Bleier, Joshua I.S., additional, Bodzin, Adam S., additional, Boland, C. Richard, additional, Bolton, John, additional, Bolton, Nathan, additional, Bonavina, Luigi, additional, Bonds, Morgan, additional, Bouwense, Stefan A.W., additional, Boys, Joshua A., additional, Bravo-Infante, Raquel, additional, Bremner, Ross M., additional, Brenner, Bruce M., additional, Brown, Shaun R., additional, Callery, Mark P., additional, Cameron, John L., additional, Camilleri, Michael, additional, Campbell, Jacob, additional, Cassim, Riaz, additional, Castillo-Angeles, Manuel, additional, Cauley, Christy, additional, Cavaness, Keith M., additional, Cerfolio, Robert J., additional, Champagne, Bradley J., additional, Chandrasoma, Parakrama, additional, Chang, Alex L., additional, Chapman, Christopher G., additional, Chapman, William C., additional, Cheek, Susannah, additional, Chen, Harvey S., additional, Cho, Clifford S., additional, Choi, Eric T., additional, Choi, Eugene A., additional, Chojnacki, Karen A., additional, Choti, Michael A., additional, Christie, Ian, additional, Chua, Heidi, additional, Church, James M., additional, Cioffi, Jessica L., additional, Clark, Susannah, additional, Clavien, Pierre-Alain, additional, Cloud, Adam, additional, Colavita, Paul D., additional, Colquhoun, Steven D., additional, Conway, William, additional, Cools-Lartigue, Jonathan, additional, Coosemans, Willy, additional, Cornwell, Edward E., additional, Costantini, Mario, additional, Coyle, Yvonne, additional, Craig, Daniel A., additional, Croome, Kristopher P., additional, Cullen, Joseph J., additional, D'Andrea, Anthony P., additional, Dassopoulos, Themistocles, additional, Davila, Marta L., additional, Davila, Raquel E., additional, DeMeester, Steven R., additional, DeMeester, Tom R., additional, Dempsey, Daniel T., additional, dePrisco, Gregory, additional, Depypere, Lieven, additional, Dietz, David W., additional, Dillhoff, Mary E., additional, DiNorcia, Joseph, additional, Doane, Stephen M., additional, Dogeas, Epameinondas, additional, Dozois, Eric J., additional, Dumon, Kristoffel, additional, Dunn, Stephen P., additional, Dunst, Christy M., additional, Dussel, John N., additional, Dyer, Matthew, additional, Efron, Jonathan, additional, El-Gohary, Yousef, additional, Lakis, Mustapha El, additional, Ellison, E. Christopher, additional, Ellsmere, James, additional, Essani, Rahila, additional, Evans, Douglas B., additional, Fang, Sandy H., additional, Fasen, Geoffrey, additional, Fernando, Hiran C., additional, Ferri, Lorenzo, additional, Fichera, Alessandro, additional, Finck, Christine, additional, Fisher, Oliver M., additional, Fleshman, James W., additional, Fong, Yuman, additional, Foreman, Michael L., additional, Francone, Todd D., additional, Franko, Edward R., additional, French, Daniel, additional, Fuchs, Hans Friedrich, additional, Fuchs, Karl Hermann, additional, Funaki, Brian, additional, Funk, Geoffrey A., additional, Fusco, Joseph, additional, Gaitonde, Shrawan G., additional, Gajjar, Aakash H., additional, Garcia-Aguilar, Julio, additional, Gearhart, Susan, additional, Geller, David A., additional, Ghobadi, Comeron, additional, Gilbert, Sebastien, additional, Giles, David, additional, Gillaspie, Erin, additional, Girotti, Micah, additional, Gittes, George K., additional, Goodman, Michael D., additional, Gooszen, Hein G., additional, Gores, Gregory J., additional, Griffin, James F., additional, Griffin, S. Michael, additional, Grimm, Leander, additional, Grochola, L.F., additional, Habib, Fahim, additional, Hanks, John B., additional, Harris, James E., additional, Hartwig, Matthew G., additional, Hassan, Imran, additional, Hedrick, Traci L., additional, Hicks, Terry C., additional, Hodin, Richard, additional, Hofstetter, Wayne L., additional, Hogg, Melissa, additional, Hu, Yue-Yung, additional, Hungness, Eric S., additional, Hunt, Steven R., additional, Huseynova, Khumara, additional, Hyman, Neil H., additional, Iannitti, David A., additional, Indes, Jeffrey, additional, Jenkins, Megan, additional, Jensen, Todd, additional, Jeziorczak, Paul M., additional, Jilani, Danial, additional, Jiménez-Toscano, Marta, additional, Jobe, Blair A., additional, Johnston, Lily E., additional, Kahrilas, Peter J., additional, Kalady, Matthew F., additional, Kassira, Noor, additional, Katkhouda, Namir, additional, Katz, Philip O., additional, Keller, Deborah S., additional, Kelley, Matthew P., additional, Kennedy, Gregory D., additional, Kent, Tara Sotsky, additional, Kia, Leila, additional, Kibbe, Melina R., additional, Kim, John, additional, King, Alice, additional, Kiran, Ravi P., additional, Kirton, Orlando C., additional, Klein, Andrew, additional, Klein, Eric N., additional, Kohn, Geoffrey P., additional, Kovell, Robert Caleb, additional, Kozol, Robert, additional, Lacy, Antonio M., additional, Ladner, Daniela P., additional, Lagarde, S.M., additional, Laituri, Carrie A., additional, Landmann, Alessandra, additional, Lee, Janet T., additional, Lee, Lawrence L., additional, Leinicke, Jennifer A., additional, Lerut, Toni, additional, Levi, David M., additional, Li, Chao, additional, Liang, Yu, additional, Lichliter, Andrew H., additional, Lichliter, Warren E., additional, Lightner, Amy L., additional, Lile, Deacon J., additional, Lillemoe, Keith D., additional, Lin, Jules, additional, Lin, Shu S., additional, Lipham, John C., additional, Litle, Virginia R., additional, Lodhia, Nayna A., additional, Longo, Walter E., additional, Lord, Reginald V.N., additional, Louie, Brian E., additional, Low, Donald E., additional, Lowe, Val J., additional, Luc, Jessica G.Y., additional, Luketich, James D., additional, Ma, Yanling, additional, MacCarty, Robert L., additional, MacDonald, Blair, additional, Madoff, Robert D., additional, Magge, Deepa, additional, Maheshwari, Anurag, additional, Mahmoud, Najjia N., additional, Mahvi, David A., additional, Mahvi, David M., additional, Mak, Grace Z., additional, Mansfield, Sara A., additional, Manzano, Maricarmen, additional, Maron, David J., additional, Mathew, Melvy S., additional, Mathis, Kellie L., additional, Matthews, Jeffrey B., additional, McFadden, David W., additional, Merchea, Amit, additional, Messaris, Evangelos, additional, Miller, Daniel L., additional, Miller, Heidi J., additional, Millis, J. Michael, additional, Mittal, Sumeet K., additional, Molena, Daniela, additional, Montgomery, Stephanie C., additional, Moore, Ryan, additional, Morgan, Katherine A., additional, Mortenson, Melinda M., additional, Mulholland, Michael W., additional, Mulvihill, Michael S., additional, Mutch, Matthew, additional, Nafteux, Philippe Robert, additional, Nagaraju, Arun, additional, Nagorney, David M., additional, Nathan, Hari, additional, Natoli, Karen R., additional, Navuluri, Rakesh, additional, Nissen, Nicholas N., additional, Nobel, Tamar B., additional, Noordman, B.J., additional, Norton, Jeffrey A., additional, Novitsky, Yuri W., additional, Nussbaum, Michael S., additional, Nyberg, Scott L., additional, Oelschlager, Brant K., additional, Oh, Daniel S., additional, Otero-Piñeiro, Ana, additional, Oto, Aytekin, additional, Pachter, H. Leon, additional, Paidas, Charles N., additional, Palazzo, Francesco, additional, Paniccia, Alessandro, additional, Papaconstantinou, Harry T., additional, Pappas, Theodore N., additional, Pappou, Emmanouil P., additional, Parikh, Manish, additional, Paruch, Jennifer L., additional, Patel, Asish D., additional, Patel, Mikin, additional, Patti, Marco G., additional, Paulson, Emily Carter, additional, Pawlik, Timothy M., additional, Payne, Isaac, additional, Pemberton, John H., additional, Pendola, Michael, additional, Perez, Alexander, additional, Pernar, Luise I.M., additional, Peters, Walter R., additional, Petrowsky, Henrik, additional, Peyre, Christian G., additional, Phillips, Alexander W., additional, Pillai, Lashmikumar, additional, Plummer, Joseph M., additional, Pointer, David T., additional, Poruk, Katherine E., additional, Posner, Mitchell C., additional, Postier, Russell, additional, Prachand, Vivek N., additional, Pritts, Timothy A., additional, Quatrino, Gregory, additional, Ranka, Sagar, additional, Rattner, David W., additional, Reavis, Kevin M., additional, Reddy, Vikram B., additional, Remzi, Feza H., additional, Ricciardi, Rocco, additional, Rice, Thomas W., additional, Richman, Aaron, additional, Rider, Paul, additional, Roberts, John Paul, additional, Roberts, Patricia L., additional, Roggin, Kevin K., additional, Roll, Garrett Richard, additional, Rona, Kais, additional, Rosen, Charles B., additional, Ross, Samuel Wade, additional, Roth, J. Scott, additional, Rushing, Amy P., additional, Safar, Bashar, additional, Saldinger, Pierre F., additional, Samakar, Kamran, additional, Sandhu, Kulmeet K., additional, Schaheen, Lara W., additional, Schirmer, Bruce, additional, Schneider, Andrew, additional, Schulick, Richard D., additional, Schwab, Ben, additional, Scurci, Stephanie, additional, Senagore, Anthony, additional, Shah, Adil A., additional, Shah, Shimul A., additional, Shames, Brian, additional, Shanmugan, Skandan, additional, Shapiro, David S., additional, Silviera, Matthew, additional, Slakey, Douglas P., additional, Sloan, Joshua, additional, Smallwood, Nathan, additional, Smith, Shane P., additional, Smithers, B. Mark, additional, Smoot, Rory L., additional, Soares, Kevin C., additional, Soffer, Edy, additional, Solomina, Julia, additional, Soper, Nathaniel J., additional, Spechler, Stuart Jon, additional, Sridhar, Praveen, additional, Steele, Scott R., additional, Sternbach, Joel M., additional, Stevenson, Christina E., additional, Strong, Scott A., additional, Sucandy, Iswanto, additional, Sundaram, Magesh, additional, Sundaresan, Sudhir, additional, Swanstrom, Lee L., additional, Sylla, Patricia, additional, Takada, Tadahiro, additional, Talbot, Ethan, additional, Tam, Vernissia, additional, Tamm, Eric P., additional, Tatarian, Talar, additional, Tavakkoli, Ali, additional, Te, Helen S., additional, Teitelbaum, Ezra N., additional, Ternent, Charles A., additional, Thompson, Jon S., additional, Thomson, Iain, additional, Thorson, Alan G., additional, Thorson, Chad M., additional, Totten, Crystal F., additional, Truty, Mark J., additional, Tsai, Susan, additional, Tseng, Jennifer, additional, Tullius, Tom, additional, Tzakis, Andreas G., additional, van Lanschot, J.J.B., additional, van Santvoort, Hjalmar C., additional, Van Veer, Hans, additional, Vega, Jorge A., additional, Velanovich, Vic, additional, Vogler, Sarah A., additional, Wang, Huamin, additional, Ward, Mark A., additional, Warner, Brad W., additional, Warner, Susanne G., additional, Watson, Thomas J., additional, Waxman, Irving, additional, Webster-Lake, Carissa, additional, Wei, Benjamin, additional, Weiser, Martin R., additional, Wells, Dennis, additional, Wells, Katerina, additional, Welton, Mark Lane, additional, Wen, Yuxiang, additional, Wendling, Mark R., additional, Wesson, Hadley K.H., additional, Wexner, Steven D., additional, White, Rebekah R., additional, Whitlow, Charles B., additional, Wijnhoven, B.P.L., additional, Wilkes, Justin, additional, Wilson, Rickesha L., additional, Witkowski, Piotr, additional, Wolfgang, Christopher L., additional, Worrell, Stephanie G., additional, Yang, Jian, additional, Yeo, Charles J., additional, Yeung, Ching, additional, Yung, Evan E., additional, Zafar, Syed Nabeel, additional, Zaninotto, Giovanni, additional, Zeh, Herbert, additional, Zehetner, Joerg, additional, Zenilman, Michael E., additional, Zimmerman, Pamela, additional, and Zuccaro, Gregory, additional

Published
2019
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15. Classification of esophageal motor findings in gastro‐esophageal reflux disease: Conclusions from an international consensus group

Author

Gyawali, C. P., Roman, S., Bredenoord, A. J., Fox, M., Keller, J., Pandolfino, J. E., Sifrim, D., Tatum, R., Yadlapati, R., Savarino, E., Azpiroz, Fernando, Babaei, Arash, Bhatia, Shobna, Boeckxstaens, Guy, Bor, Serhat, Carlson, Dustin, Castell, Donald, Cicala, Michele, Clarke, John, De Bortoli, Nicola, Drug, Vasile, Frazzoni, Marzio, Holloway, Richard, Kahrilas, Peter, Kandulski, Arne, Katz, Phil, Katzka, David, Mittal, Ravinder, Mion, Francois, Novais, Luis, Patel, Amit, Penagini, Roberto, Ribolsi, Mentore, Richter, Joel, Salvador, Renato, Savarino, Vincenzo, Serra, Jordi, Schnoll‐Sussman, Felice, Smout, Andre, Soffer, Edy, Sweis, Rami, Tack, Jan, Tolone, Salvatore, Tutuian, Radu, Vaezi, Michael, Vela, Marcelo, Woodland, Philip, Wu, Justin, Xiao, Yinglian, and Zerbib, Frank

Published
2017
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16. Ambulatory reflux monitoring for diagnosis of gastro‐esophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group

Author

Roman, S., Gyawali, C. P., Savarino, E., Yadlapati, R., Zerbib, F., Wu, J., Vela, M., Tutuian, R., Tatum, R., Sifrim, D., Keller, J., Fox, M., Pandolfino, J. E., Bredenoord, A. J., Azpiroz, Fernando, Babaei, Arash, Bhatia, Shobna, Boeckxstaens, Guy, Bor, Serhat, Carlson, Dustin, Castell, Donald, Cicala, Michele, Clarke, John, De Bortoli, Nicola, Drug, Vasile, Frazzoni, Marzio, Holloway, Richard, Kahrilas, Peter, Kandulski, Arne, Katz, Phil, Katzka, David, Mittal, Ravinder, Mion, Francois, Novais, Luis, Patel, Amit, Penagini, Roberto, Ribolsi, Mentore, Richter, Joel, Salvador, Renato, Savarino, Vincenzo, Serra, Jordi, Schnoll‐Sussman, Felice, Smout, Andre, Soffer, Edy, Sweis, Rami, Tack, Jan, Tolone, Salvatore, Vaezi, Michael, Woodland, Philip, and Xiao, Yinglian

Published
2017
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32. The effect of eating on lower esophageal sphincter electrical activity

Author

Sanmiguel, Claudia P., Ito, Yuichiro, Hagiike, Masanobu, Conklin, Jeffrey L., Lalezari, David, and Soffer, Edy E.

Subjects
Esophagus -- Properties, Sphincters -- Properties, Electrophysiology -- Research, Gastrointestinal system -- Motility, Gastrointestinal system -- Research, Biological sciences
Abstract

Electrical activity of the lower esophageal sphincter (LES) has been recorded mainly in vitro and in anesthetized animals. Swallowing produces relaxation of the LES, followed by its contraction. These changes should be associated with changes in LES electrical activity. To determine whether changes in LES electrical activity can be used to recognize the beginning of a meal, four dogs were implanted with two electrodes in the longitudinal axis of the LES. The electrodes were connected to an implantable device for recording of electrical activity. After recovery, dogs underwent two experiments: 1) combined recordings of LES electrical activity and esophageal manometry to test the effect of dry swallows, water, and solid food swallows on LES electrical activity and 2) telemetric recording of LES electrical activity during a standard meal. All amplitudes were in mV, means [+ or -] SD, ANOVA, P < 0.05. In experiment 1, an increase in the amplitude of LES electrical activity was associated with the substance being swallowed, i.e., at rest: 0.31 [+ or -] 0.06; dry swallows: 0.6 [+ or -] .0.1; water: 0.67 [+ or -] 0.12; solid food: 1.06 [+ or -] 0.17, P < 0.001. In experiment 2, there was a pronounced and characteristic increase in amplitude of LES electrical activity during feeding, 0.26 [+ or -] 0.1; during fasting, 0.99 [+ or -] 0.23; while eating, 0.31 [+ or -] 0.1 postprandial, P < 0.001. In conclusion, the beginning and duration of a meal are identified by distinct, easily recognizable changes in the amplitude of LES electrical activity. These changes depend on the type of the substance being swallowed and are most prominent with solid food. Changes in LES electrical activity can potentially be used for automatic eating detection. esophagus; myoelectrical activity; swallowing; esophageal motility

Published
2009

33. Effect of electrical stimulation of the LES on LES pressure in a canine model

Author

Sanmiguel, Claudia P., Hagiike, Masanobu, Mintchev, Martin P., Dela Cruz, Ryan, Phillips, Edward H., Cunneen, Scott A., Conklin, Jeffrey L., and Soffer, Edy E.

Subjects
Neural stimulation -- Methods, Neural stimulation -- Influence, Sphincters -- Properties, Cholinergic mechanisms -- Properties, Biological sciences
Abstract

Gastric electrical stimulation modulates lower esophageal sphincter pressure (LESP). High-frequency neural stimulation (NES) can induce gut smooth muscle contractions. To determine whether lower esophageal sphincter (LES) electrical stimulation (ES) can affect LESP, bipolar electrodes were implanted in the LES of four dogs. Esophageal manometry during sham or ES was performed randomly on separate days. Four stimuli were used: 1) low-frequency: 350-ms pulses at 6 cycles/min; 2) high-frequency-l: 1-ms pulses at 50 Hz; 3) highfrequency-2: 1-ms pulses at 20 Hz; and 4) NES: 20-ms bipolar pulses at 50 Hz. Recordings were obtained postprandially. Tests consisted of three 20-min periods: baseline, stimulation/sham, and poststimulation. The effect of NES was tested under anesthesia and following IV administration of L-NAME and atropine. Area under the curve (AUC) and LESP were compared among the three periods, by ANOVA and t-test, P < 0.05. Data are shown as means [+ or -] SD. We found that low-frequency stimulation caused a sustained increase in LESP: 32.1 [+ or -] 12.9 (prestimulation) vs. 43.2 [+ or -] 18.0 (stimulation) vs. 50.1 [+ or -] 23.8 (poststimulation), P < 0.05. AUC significantly increased during and after stimulation. There were no significant changes with other types of ES. With NES, LESP initially rose and then decreased below baseline (LES relaxation). During NES, [N.sup.G]-nitro-L-arginine methyl ester increased both resting LESP and the initial rise in LESP and markedly diminished the relaxation. Atropine lowered resting LESP and abolished the initial rise in LESP. In conclusion, low frequency ES of the LES increases LESP in conscious dogs. NES has dual effect on LESP: an initial stimulation, cholinergically mediated, followed by relaxation mediated by nitric oxide. electrical stimulation; lower esophageal sphincter pressure; nitric; cholinergic; neural electrical stimulation

Published
2008

39. Study of intestinal flow by combined videofluoroscopy, manometry, and multiple intraluminal impedance

Author

Imam, Hala, Sanmiguel, Claudia, Larive, Brett, Bhat, Yasser, and Soffer, Edy

Subjects
Intestines -- Research, Biological sciences
Abstract

Assessment of patterns of flow in the small bowel is difficult. Multiple intraluminal impedance has been recently used for study of flow dynamics in the esophagus. Our aims were 1) to validate multiple intraluminal impedance by correlating impedance events with intestinal flow as detected by fluoroscopy and 2) to determine intestinal flow patterns in the fasting and postprandial period and their correspondence with manometry. First, six healthy subjects underwent simultaneous videofluoroscopic, manometric, and impedance recording from the duodenum. Videofluoroscopy was used to validate impedance patterns corresponding with barium flow in the fasting and postprandial periods. Next, 16 healthy subjects underwent prolonged simultaneous recording of impedance and manometry in both periods. Most flow events were short (10 cm or less), with antegrade flow being the most common. Correspondence between impedance and videofluoroscopy increased with increasing length of barium flow. Impedance corresponded better with flow, at any distance, than manometry. However, impedance and manometric events, when analyzed separately as index events, always corresponded with fluoroscopic flow. The fasting and postprandial periods showed comparable patterns of flow, with frequent, highly propulsive manometric and impedance sequences. Motility index was positively and significantly associated with length of impedance events. Phase 3 of the migrating motor complex could be easily recognized by impedance. Multiple intraluminal impedance can detect intestinal flow events and corresponds better with fluoroscopic flow than manometry. multichannel intraluminal impedance; manometry; fluoroscopy; intestinal motility

Published
2004

41. The effect of gastric electrical stimulation on canine gastric slow waves

Author

Xing, Jinhong, Brody, Frederick, Rosen, Michael, Chen, J.D.Z., and Soffer, Edy

Subjects
Human physiology -- Research, Electric stimulation -- Physiological aspects, Electric stimulation -- Research, Biological sciences
Abstract

This study determined the most efficient parameters of low-frequency/long-pulse gastric electrical stimulation (GES) required to entrain gastric slow waves and also evaluated the effect of entrainment and high-frequency, short-pulse GES on gastric electrical activity (GEA). Nine dogs were fitted with stimulation wires along the greater curvature. Entrainment was observed in six or seven animals, with long-pulse GES at six cycles per minute (cpm), at various combinations of current and pulse width and was directly related to the energy delivered. Entrainment was observed in four to seven animals, with GES at 12 cpm, and the maximal driven frequency was 6 cpm. Entrainment did not significantly increase the dominant power of GEA. High-frequency, shortpulse GES, using pulse trains of 14 Hz, 5 mA, and 330 [micro]s, with 0.1 s on and 5 s off, and pulse trains of 40 Hz, 10 mA, and 330 [micro]s, with 2 s on 3 s off, did not affect variables of GEA. We conclude that acute low-frequency GES but not high-frequency, short-pulse GES can entrain slow waves; the power of slow waves is not affected by either type of stimulation. low-frequency, long-pulse gastric electrical stimulation; high-frequency, short-pulse gastric electrical stimulation

Published
2003

46. Contributors

Author

Abdelmalak, Joseph B., primary, Abelson, Abby, additional, Absi, Ahmed, additional, Achkar, Edgar, additional, Adelstein, David J., additional, Adhami, Talal, additional, Adury, Kamal, additional, Advani, Anjali, additional, Al-Ashkar, Feyrouz, additional, AlMahameed, Amjad, additional, Amado, Antoine, additional, Armogida, Sheila, additional, Armstrong, Wendy S., additional, Arroliga, Mercedes E., additional, Arroliga, Alejandro C., additional, Ashton, Kathleen, additional, Askari, Arman, additional, Atanaskova, Natasha, additional, Attaran, Marjan, additional, Aucejo, Federico, additional, Austerman, Joseph, additional, Avery, Robin, additional, Aydin, H. Nail, additional, Barnes, David, additional, Bartholomew, John R., additional, Batur, Pelin, additional, Baz, Rachid, additional, Bergfeld, Wilma, additional, Bhatt, Deepak, additional, Bharadwaj, Swati, additional, Bianchi, Laura K., additional, Boike, Allan, additional, Bolooki, Michael H., additional, Bolwell, Brian, additional, Bott-Silverman, Corinne, additional, Boyle, Andrew, additional, Bradley, Linda, additional, Braun, William E., additional, Braver, Yvonne, additional, Brener, Sorin J., additional, Brethauer, Stacy, additional, Budev, Marie M., additional, Bunyard, Matthew, additional, Burke, Carol, additional, Butt, Saud, additional, Calabrese, Leonard, additional, Camisa, Charles, additional, Caldwell, Darwin L., additional, Carey, John, additional, Carey, William D., additional, Cesario, Karin, additional, Cevasco, Nathaniel, additional, Chapman, Jeffrey T., additional, Chatterjee, Soumya, additional, Chen, Michael C., additional, Cherian, Neil, additional, Chinnappa, Priya, additional, Choure, Anuja, additional, Chung, Jeffrey Y., additional, Collins, Gregory B., additional, Covington, Edward C., additional, Culver, Daniel A., additional, Curtin, Ronan, additional, Davis, Mellar, additional, Deitcher, Steven, additional, Demirjian, Sevag, additional, Dreicer, Robert, additional, Dresing, Thomas J., additional, Dweik, Raed A., additional, Eghtesad, Bijan, additional, Elder, Julie A., additional, Embi, Peter J., additional, Englund, Kristin, additional, Erzurum, Serpil, additional, Factora, Ronan, additional, Fairbanks, Kyrsten, additional, Faith-Fernandez, Esteban, additional, Falcone, Tatiana, additional, Falcone, Tommaso, additional, Falk, Gary W., additional, Fanning, Suzanne R., additional, Fatica, Richard, additional, Fattal, Omar, additional, Faulx, Michael, additional, File, Elizabeth, additional, Fleseriu, Maria, additional, Fouad-Tarazi, Fetnat, additional, Fowler, Adele, additional, Fox, Robert, additional, Franco, Kathleen N., additional, Fraser, Thomas G., additional, Freda, Benjamin J., additional, Freeman, Katherine, additional, Fung, John J., additional, Garcia, Jorge, additional, Gildea, Thomas R., additional, Golish, Joseph A., additional, Gopinath, Anil, additional, Gordon, Steven, additional, Grandinetti, Lisa, additional, Grasso, Adam, additional, Griffin, Brian, additional, Grimm, Richard, additional, Hajj-Ali, Rula A., additional, Hall, Philip, additional, Hamrahian, Amir H., additional, Harrison, Shannon, additional, Hermida, Teresa, additional, Hernández-Rodriguez, José, additional, Heyka, Robert, additional, Hoffman, Gary S., additional, Hobbs, Robert, additional, Hong, Sandra, additional, Hoogwerf, Byron, additional, Hsieh, Fred, additional, Huang, Julie, additional, Husni, M. Elaine, additional, Ioachimescu, Adriana G., additional, Ioachimescu, Octavian C., additional, Isaacson, Harry J., additional, Isada, Carlos M., additional, Issa, Naim, additional, Jaber, Wael A., additional, Jacob, Ron, additional, Jaeger, Fredrick J., additional, Jaeger, Fred, additional, Jin, Xian Wen, additional, Juvelekian, Georges, additional, Kashyap, Sangeeta, additional, Katzan, Irene, additional, Kaur, Gurjit, additional, Kavuru, Mani, additional, Keys, Thomas F., additional, Khalife, Sami, additional, Khalil, Mazen K., additional, Khasnis, Atul, additional, Kim, Esther S.H., additional, Kim, Richard, additional, Kim, Alice, additional, Koelsch, R., additional, Koening, Curry L., additional, Kooken, Ann R., additional, Kothari, Shakuntala, additional, Krasuski, Richard A., additional, Kunkel, Robert, additional, Lakin, Milton, additional, Lang, David M., additional, LaRosa, Steven P., additional, Lascano, Martin E., additional, Lashner, Bret, additional, Leung, Anthony K., additional, Lever, Harry, additional, Lever, David S., additional, Levin, Kerry H., additional, Lichtin, Alan, additional, Lifshitz, Oren H., additional, Lim, Li Ling, additional, Logan, Daniel, additional, Lucas, Jennifer, additional, Magrey, Marina, additional, Maier, Michael, additional, Malone, Donald, additional, Manzon, Judith, additional, Maroo, Anjli, additional, Mathews, Manu, additional, Mawhorter, Steven D., additional, Mayer, Mark, additional, Mayuga, Ken, additional, Mazzone, Peter J., additional, McAllister, Mark S., additional, McCarthy, Kevin, additional, Maksimowicz-McKinnonn, Kathleen, additional, Mehta, Adi, additional, Mehta, Atul C., additional, Mekhail, Tarek, additional, Miller, Charles M., additional, Moffa, Donald, additional, Moheet, Asma, additional, Molloy, Eamonn, additional, Moore, Halle, additional, Morledge, Thomas, additional, Mossad, Sherif B., additional, Muthusamy, Preetha, additional, Muzina, David J., additional, Nair, Dileep, additional, Nally, Joseph, additional, Nasr, Christian, additional, Noeller, Thomas P., additional, Novaro, Gian M., additional, Nurko, Saul, additional, O'Shea, Robert S., additional, Padmanabhan, Ravindran, additional, Paschall, Velma L., additional, Pien, Lily C., additional, Piliang, Melissa, additional, Pimental, Ronnie, additional, Poggio, Emilio D., additional, Potts, Jeannette M., additional, Pozuelo, Leo, additional, Procop, Gary W., additional, Qadeer, Mohammed, additional, Radojicic, Christine, additional, Rafey, Mohammed, additional, Ranes, Justin L., additional, Raymond, Russell, additional, Remzi, Feza, additional, Rice, Thomas, additional, Rodriguez, Cristina, additional, Rowney, Jess, additional, Sabella, Camille, additional, Sabecks, Ronald M., additional, Sachdeva, Mandi, additional, Foldvary-Schaefer, Nancy, additional, Schauer, Philip, additional, Scheetz, Raymond, additional, Schmitt, Steven, additional, Schrieber, Martin, additional, Seballos, Raul J., additional, Schweikert, Robert A., additional, Sekeres, Mikkael A., additional, Shen, Bo, additional, Shields, Jr., Robert W., additional, Shivadas, Anita, additional, Shoemaker, Laura, additional, Shrestha, Nabin K., additional, Shrestha, Rabin K., additional, Silver, Bernard J., additional, Singh, Rishi P., additional, Singh, Vivek, additional, Skugor, Mario, additional, Smith, Stephen, additional, Soffer, Edy, additional, Solaiman, Firas Al, additional, Sood, Apra, additional, Stephany, Brian R., additional, Stevens, Tyler, additional, Stevens, Glen H.J., additional, Stoller, James K., additional, Streem, David, additional, Sweeney, Patrick, additional, Swiencicki, James F., additional, Taege, Alan, additional, Taliercio, Rachel M., additional, Tallman, Thomas, additional, Tavee, Jinny, additional, Tavill, Anthony, additional, Taylor, David, additional, Taylor, James S., additional, Tesar, George E., additional, Thacker, Holly L., additional, Theil, Karl, additional, Thornton, Sharon Longshore, additional, Tomecki, Kenneth J., additional, Tomford, Walton J., additional, Tung, Rebecca, additional, Tungsiripat, Marisa, additional, Vidimos, Allison, additional, Vogel, Nicola M., additional, Wakim-Fleming, Jamile, additional, Boon Wee, Teo, additional, Whinney, Christopher, additional, Wieckowska, Anna, additional, Wiedemann, Herbert P., additional, Wilke, William, additional, Woodhouse, Justin G., additional, Wright, Bridget, additional, Yamani, Mohamad, additional, Zanotti, Kristine, additional, Zein, Claudia O., additional, Zimmerman, Robert, additional, and Zirwas, Matthew J., additional

Published
2010
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