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1. Personalized bacteriophage therapy outcomes for 100 consecutive cases: a multicentre, multinational, retrospective observational study

Author

Pirnay, Jean-Paul, Djebara, Sarah, Steurs, Griet, Griselain, Johann, Cochez, Christel, De Soir, Steven, Glonti, Tea, Spiessens, An, Vanden Berghe, Emily, Green, Sabrina, Wagemans, Jeroen, Lood, Cédric, Schrevens, Eddie, Chanishvili, Nina, Kutateladze, Mzia, de Jode, Mathieu, Ceyssens, Pieter-Jan, Draye, Jean-Pierre, Verbeken, Gilbert, De Vos, Daniel, Rose, Thomas, Onsea, Jolien, Van Nieuwenhuyse, Brieuc, Soentjens, Patrick, Lavigne, Rob, and Merabishvili, Maya

Published
2024
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5. Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak

Author

Van Dijck, Christophe, Hens, Matilde, Van Esbroeck, Marjan, Brosius, Isabel, Liesenborghs, Laurens, Van Gestel, Liesbeth, Rutgers, Jojanneke, Kenyon, Chris, De Baetselier, Irith, Coppens, Jasmine, Van den Bossche, Dorien, Florence, Eric, Vercauteren, Koen, van Griensven, Johan, Bottieau, Emmanuel, Soentjens, Patrick, Berens-Riha, Nicole, van Henten, Saskia, Bracke, Stefanie, Vanbaelen, Thibaut, Vandenhoven, Leen, Van Frankenhuijsen, Maartje, Vandenbruaene, Marc, Huyst, Veerle, Wouters, Kristien, Apers, Ludwig, Kint, Ilse, Caluwaerts, Séverine, Vanroye, Fien, Verschueren, Jacob, and Ariën, Kevin

Published
2023
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6. Epidemiological and clinical characteristics of patients with monkeypox in the GeoSentinel Network: a cross-sectional study

Author

Blumberg, Lucille, Chaussade, Hélène, Desclaux, Arnaud, Florence, Eric, Aysel Florescu, Simin, Glans, Hedvig, Glynn, Marielle, Goorhuis, Abraham, Klein, Marina, Malvy, Denis, McCollum, Andrea, Muñoz, José, Nguyen, Duc, Quilter, Laura, Rothe, Camilla, Soentjens, Patrick, Tumiotto, Camille, Vanhamel, Jef, Angelo, Kristina M, Smith, Teresa, Camprubí-Ferrer, Daniel, Balerdi-Sarasola, Leire, Díaz Menéndez, Marta, Servera-Negre, Guillermo, Barkati, Sapha, Duvignaud, Alexandre, Huber, Kristina L B, Chakravarti, Arpita, Bottieau, Emmanuel, Greenaway, Christina, Grobusch, Martin P, Mendes Pedro, Diogo, Asgeirsson, Hilmir, Popescu, Corneliu Petru, Martin, Charlotte, Licitra, Carmelo, de Frey, Albie, Schwartz, Eli, Beadsworth, Michael, Lloveras, Susana, Larsen, Carsten S, Guagliardo, Sarah Anne J, Whitehill, Florence, Huits, Ralph, Hamer, Davidson H, Kozarsky, Phyllis, and Libman, Michael

Published
2023
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7. Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Garibaldi, Brian T., Albertson, Timothy E., Sandrock, Christian, Lee, Janet S., Looney, Mark R., Tapson, Victor F., Wiysonge, Charles Shey, Velarde, Luis Humberto Anaya, Backenroth, Daniel, Bhushanan, Jisha, Brandenburg, Börries, Cárdenas, Vicky, Chen, Bohang, Chen, Fei, Chetty, Polan, Chu, Pei-Ling, Cooper, Kimberly, Custers, Jerome, Delanghe, Hilde, Duca, Anna, Henrick, Tracy, Juraszek, Jarek, Nalpas, Catherine, Peeters, Monika, Pinheiro, Jose, Roels, Sanne, Ryser, Martin F., Salas, Jose, Santoro Matias, Samantha, Scheys, Ilse, Shetty, Pallavi, Shukarev, Georgi, Stoddard, Jeffrey, Talloen, Willem, Tran, NamPhuong, Vaissiere, Nathalie, van Son-Palmen, Elisabeth, Xu, Jiajun, Goecker, Erin A., Greninger, Alexander L., Jerome, Keith R., Roychoudhury, Pavitra, Takuva, Simbarashe G., Accini Mendoza, Jose Luis, Achtyes, Eric, Ahsan, Habibul, Alhatemi, Azhar, Allen, Nancy, Arribas, Jose R., Bahrami, Ghazaleh, Bailon, Lucia, Bajwa, Ali, Baker, Jonathan, Baron, Mira, Benet, Susana, Berdaï, Driss, Berger, Patrick, Bertoch, Todd, Bethune, Claire, Bevilacqua, Sybille, Biagioni Santos, Maria Silvia, Binnian, Ian, Bisnauthsing, Karen, Boivin, Jean-Marc, Bollen, Hilde, Bonnet, Sandrine, Borobia, Alberto M., Botelho-Nevers, Elisabeth, Bright, Phil, Britten, Vianne, Brown, Claire, Buadi, Amanda, Buntinx, Erik, Burgess, Lesley, Bush, Larry, Capeding, Maria Rosario, Carr, Quito Osuna, Carrasco Mas, Amparo, Catala, Hélène, Cathie, Katrina, Caudill, T. Shawn, Cereto Castro, Fernando, Chau, Kénora, Chavoustie, Steven, Chowdhury, Marie, Chronos, Nicolas, Cicconi, Paola, Cifuentes, Liliana, Cobo, Sara Maria, Collins, Helen, Colton, Hayley, Cuaño, Carlos Rolando G., D'Onofrio, Valentino, Dargan, Paul, Darton, Thomas, Deane, Peter, Del Pozo, Jose Luis, Derdelinckx, Inge, Desai, Amisha, Dever, Michael, Díaz-Pollán, Beatriz, DiBuono, Mark, Doust, Matthew, Duncan, Christopher, Echave-Sustaeta, Jose Maria, Eder, Frank, Ellis, Kimberly, Elzi, Stanton, Emmett, Stevan, Engelbrecht, Johannes, Evans, Mim, Farah, Theo, Felton, Timothy, Ferreira, João Pedro, Floutier, Catherine, Flume, Patrick, Ford, Stacy, Fragoso, Veronica, Freedman, Andrew, Frentiu, Emilia, Galloway, Christopher, Galtier, Florence, Garcia Diaz, Julia, García García, Irene, Garcia, Alcaide, Gardener, Zoe, Gauteul, Pascale, Geller, Steven, Gibson, Andrew, Gillet, Claudia, Girerd, Nicolas, Girodet, Pierre-Olivier, Gler, Maria Tarcela, Glover, Richard, Go, Herschel Don D., Gokani, Karishma, Gonthier, Damien, Green, Christopher, Greenberg, Richard, Griffin, Carl, Grobbelaar, Coert, Guancia, Adonis, Hakkarainen, Gloria, Harris, James, Hassman, Michael, Heimer, Deirdre, Hellstrom-Louw, Elizabeth, Herades, Yoan, Holroyd, Christopher, Hussen, Nazreen, Isidro, Marie Grace Dawn, Jackson, Yvonne, Jain, Manish, João Filho, Esaú Custódio, Johnson, Daniel, Jones, Ben, Joseph, Natasha, Jumeras, Analyn, Junquera, Patricia, Kellett-Wright, Johanna, Kennedy, Patrick, Kilgore, Paul E., Kim, Kenneth, Kimmel, Murray, Konis, George, Kutner, Mark, Lacombe, Karine, Launay, Odile, Lazarus, Rajeka, Lederman, Samuel, Lefebvre, Gigi, Lennon Collins, Katrina, Leroux-Roels, Isabel, Lim, Kenneth Wilson O., Lins, Muriel, Liu, Edward, Llewelyn, Martin, Mahomed, Akbar, Maia, Bernardo Porto, Marín-Candon, Alícia, Martínez-Gómez, Xavier, Martinot, Jean Benoit, Mazzella, Andrea, McCaughan, Frank, McCormack, Louise, McGettigan, John, Mehra, Purvi, Mejeur, Rhonda, Miller, Vicki, Mills, Anthony, Molto Marhuenda, Jose, Moodley, Prebashan, Mora-Rillo, Marta, Mothe, Beatriz, Mullan, Daniel, Munro, Alasdair, Myers, Paul, Nell, Jeremy, Newman Lobato Souza, Tamara, O'Halloran, Jane A., Ochoa Mazarro, Maria Dolores, Oliver, Abigail, Onate Gutierrez, Jose Millan, Ortega, Jessica, Oshita, Masaru, Otero Romero, Susana, Overcash, Jeffrey Scott, Owens, Daniel, Packham, Alice, Pacurar, Mihaela, Paiva de Sousa, Leonardo, Palfreeman, Adrian, Pallares, Christian José, Patel, Rahul, Patel, Suchet, Pelkey, Leslie, Peluso, Denise, Penciu, Florentina, Pinto, S. Jerry, Pounds, Kevin, Pouzar, Joe, Pragalos, Antoinette, Presti, Rachel, Price, David, Qureshi, Ehsaan, Ramalho Madruga, José Valdez, Ramesh, Mayur, Rankin, Bruce, Razat, Béatrice, Riegel Santos, Breno, Riesenberg, Robert, Riffer, Ernie, Roche, Siobhan, Rose, Katie, Rosellini, Pietro, Rossignol, Patrick, Safirstein, Beth, Salazar, Hernan, Sanchez Vallejo, Gregorio, Santhosh, Smrithi, Seco-Meseguer, Enrique, Seep, Michael, Sherry, Emma, Short, Philip, Soentjens, Patrick, Solis, Joel, Soriano Viladomiu, Alejandro, Sorli, Caroline, Spangenthal, Selwyn, Spence, Niamh, Stephenson, Elaine, Strout, Cynthia, Surowitz, Ronald, Taladua, Kristy Michelle, Tellalian, David, Thalamas, Claire, Thiriphoo, Nang, Thomas, Judith, Thomas, Nicholas, Trout, Guillermo, Urroz, Mikel, Veekmans, Bernard, Veekmans, Laurent, Villalobos, Ralph Elvi M., Warren, Sarah, Webster, Brian, White, Alexander, Williams, Gail, Williams, Hayes, Wilson, Barbara, Winston, Alan, Wiselka, Martin, Zervos, Marcus, Hardt, Karin, Vandebosch, An, Sadoff, Jerald, Le Gars, Mathieu, Truyers, Carla, Lowson, David, Van Dromme, Ilse, Vingerhoets, Johan, Kamphuis, Tobias, Scheper, Gert, Ruiz-Guiñazú, Javier, Faust, Saul N, Spinner, Christoph D, Schuitemaker, Hanneke, Van Hoof, Johan, Douoguih, Macaya, and Struyf, Frank

Published
2022
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8. Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler

Author

Van Nieuwenhuyse, Brieuc, Van der Linden, Dimitri, Chatzis, Olga, Lood, Cédric, Wagemans, Jeroen, Lavigne, Rob, Schroven, Kaat, Paeshuyse, Jan, de Magnée, Catherine, Sokal, Etienne, Stéphenne, Xavier, Scheers, Isabelle, Rodriguez-Villalobos, Hector, Djebara, Sarah, Merabishvili, Maya, Soentjens, Patrick, and Pirnay, Jean-Paul

Published
2022
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11. Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak

Author

Hens, Matilde, primary, Brosius, Isabel, additional, Berens-Riha, Nicole, additional, Coppens, Jasmine, additional, Van Gestel, Liesbeth, additional, Rutgers, Jojanneke, additional, Kenyon, Chris, additional, Soentjens, Patrick, additional, van Henten, Saskia, additional, Bracke, Stefanie, additional, Vanbaelen, Thibaut, additional, Vandenhoven, Leen, additional, Bottieau, Emmanuel, additional, Vercauteren, Koen, additional, Van Esbroeck, Marjan, additional, Liesenborghs, Laurens, additional, Van Dijck, Christophe, additional, Hens, Matilde, additional, De Baetselier, Irith, additional, Van den Bossche, Dorien, additional, Florence, Eric, additional, van Griensven, Johan, additional, Van Frankenhuijsen, Maartje, additional, Vandenbruaene, Marc, additional, Huyst, Veerle, additional, Wouters, Kristien, additional, Apers, Ludwig, additional, Kint, Ilse, additional, Caluwaerts, Séverine, additional, Vanroye, Fien, additional, Verschueren, Jacob, additional, and Ariën, Kevin, additional

Published
2023
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12. Alternative sampling specimens for the molecular detection of mpox (formerly monkeypox) virus

Author

Coppens, Jasmine, primary, Vanroye, Fien, additional, Brosius, Isabel, additional, Liesenborghs, Laurens, additional, van Henten, Saskia, additional, Vanbaelen, Thibaut, additional, Bracke, Stefanie, additional, Berens-Riha, Nicole, additional, De Baetselier, Irith, additional, Kenyon, Chris, additional, Soentjens, Patrick, additional, Florence, Eric, additional, Van Griensven, Johan, additional, Ariën, Kevin K., additional, Jacobs, Bart K.M., additional, Van den Bossche, Dorien, additional, Van Esbroeck, Marjan, additional, Vercauteren, Koen, additional, Van Dijck, Christophe, additional, Ramadan, Kadrie, additional, Van Looveren, Karin, additional, Baeyens, Jolien, additional, Van Hoyweghen, Cindy, additional, Mangelschots, Marianne, additional, Coppens, Sandra, additional, Heyndrickx, Leo, additional, Michiels, Johan, additional, De Block, Tessa, additional, Laga, Marie, additional, Vanhamel, Jef, additional, Vuylsteke, Bea, additional, Bottieau, Emmanuel, additional, Vandenhove, Leen, additional, Selhorst, Philippe, additional, Rezende, Antonio Mauro, additional, Smet, Hilde, additional, Rasson, Hanne, additional, Verschueren, Jacob, additional, Platteau, Tom, additional, Hauner, Anne, additional, and Willems, Betty, additional

Published
2023
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13. Epidemiological and clinical characteristics of patients with monkeypox in the GeoSentinel Network: a cross-sectional study

Author

Angelo, Kristina M, primary, Smith, Teresa, additional, Camprubí-Ferrer, Daniel, additional, Balerdi-Sarasola, Leire, additional, Díaz Menéndez, Marta, additional, Servera-Negre, Guillermo, additional, Barkati, Sapha, additional, Duvignaud, Alexandre, additional, Huber, Kristina L B, additional, Chakravarti, Arpita, additional, Bottieau, Emmanuel, additional, Greenaway, Christina, additional, Grobusch, Martin P, additional, Mendes Pedro, Diogo, additional, Asgeirsson, Hilmir, additional, Popescu, Corneliu Petru, additional, Martin, Charlotte, additional, Licitra, Carmelo, additional, de Frey, Albie, additional, Schwartz, Eli, additional, Beadsworth, Michael, additional, Lloveras, Susana, additional, Larsen, Carsten S, additional, Guagliardo, Sarah Anne J, additional, Whitehill, Florence, additional, Huits, Ralph, additional, Hamer, Davidson H, additional, Kozarsky, Phyllis, additional, Libman, Michael, additional, Blumberg, Lucille, additional, Chaussade, Hélène, additional, Desclaux, Arnaud, additional, Florence, Eric, additional, Aysel Florescu, Simin, additional, Glans, Hedvig, additional, Glynn, Marielle, additional, Goorhuis, Abraham, additional, Klein, Marina, additional, Malvy, Denis, additional, McCollum, Andrea, additional, Muñoz, José, additional, Nguyen, Duc, additional, Quilter, Laura, additional, Rothe, Camilla, additional, Soentjens, Patrick, additional, Tumiotto, Camille, additional, and Vanhamel, Jef, additional

Published
2023
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14. Persistent morbidity in Clade IIb mpox patients: interim results of a long-term follow-up study, Belgium, June to November 2022

Author

Berens-Riha, Nicole, Bracke, Stefanie, Rutgers, Jojanneke, Burm, Christophe, Van Gestel, Liesbeth, Hens, Matilde, Kenyon, Chris, Bottieau, Emmanuel, Soentjens, Patrick, Brosius, Isabel, Van Esbroeck, Marjan, Vercauteren, Koen, van Griensven, Johan, van Dijck, Christophe, and Liesenborghs, Laurens

Subjects
Epidemiology, medium-term follow-up, Public Health, Environmental and Occupational Health, long-term follow-up, Monkeypox, sequelae, Disease Outbreaks, mpox, Belgium, Virology, follow-up, Humans, fatigue, Prospective Studies, Morbidity, Follow-Up Studies
Abstract

While mpox was well characterised during the 2022 global Clade IIb outbreak, little is known about persistent morbidity. We present interim results of a prospective cohort study of 95 mpox patients assessed 3-20 weeks post-symptom onset. Two-thirds of participants had residual morbidity, including 25 with persistent anorectal and 18 with genital symptoms. Loss of physical fitness, new-onset/worsened fatigue and mental health problems were reported in 36, 19 and 11 patients, respectively. These findings require attention by healthcare providers. ispartof: EUROSURVEILLANCE vol:28 issue:7 ispartof: location:Sweden status: published

Published
2023

15. Five accelerated schedules for the tick-borne encephalitis vaccine FSME-Immun (R) in last-minute travellers : an open-label, single-centre, randomized controlled pilot trial

Author

Berens-Riha, Nicole, Andries, Petra, Aerssens, Annelies, Ledure, Quentin, van der Beken, Yolien, Heyndrickx, Leo, Genbrugge, Els, Tsoumanis, Achilleas, Van Herrewege, Yven, Ariën, Kevin, Van Innis, Martine, Vanbrabant, Peter, Soentjens, Patrick, and FASTBEPROTECT Research Team

Subjects
Human medicine
Abstract

Background The purpose of this exploratory study was to evaluate different accelerated tick-borne encephalitis (TBE) vaccine schedules for last-minute travellers. Methods In a single-centre, open-label pilot study, 77 TBE-naive Belgian soldiers were randomized to one of the following five schedules with FSME-Immun (R): group 1 ('classical accelerated' schedule) received one intramuscular (IM) dose at Day 0 and Day 14, group 2 two IM doses at Day 0, group 3 two intradermal (ID) doses at Day 0, group 4 two ID doses at Day 0 and Day 7 and group 5 two ID doses at Day 0 and Day 14. The last dose(s) of the primary vaccination scheme were given after 1 year: IM (1 dose) or ID (2 doses). TBE virus neutralizing antibodies were measured in a plaque reduction neutralization test (PRNT90 and 50) at Days 0, 14, 21, 28, Months 3, 6, 12 and 12+21 days. Seropositivity was defined as neutralizing antibody titres >= 10. Results The median age was 19-19.5 years in each group. Median time to seropositivity up to Day 28 was shortest for PRNT90 in ID-group 4 and for PRNT50 in all ID groups. Seroconversion until Day 28 peaked highest for PRNT90 in ID-group 4 (79%) and for PRNT50 in ID-groups 4 and 5 (both 100%). Seropositivity after the last vaccination after 12 months was high in all groups. Previous yellow fever vaccination was reported in 16% and associated with lower geometric mean titres of TBE-specific antibodies at all-time points. The vaccine was generally well tolerated. However, mild to moderate local reactions occurred in 73-100% of ID compared with 0-38% of IM vaccinations, and persistent discolouration was observed in nine ID vaccinated individuals. Conclusion The accelerated two-visit ID schedules might offer a better immunological alternative to the recommended classical accelerated IM schedule, but an aluminium-free vaccine would be preferable.

Published
2023

16. Mpox screening in high-risk populations finds no asymptomatic cases

Author

Van Dijck, Christophe, primary, De Baetselier, Irith, additional, Kenyon, Chris, additional, Liesenborghs, Laurens, additional, Vercauteren, Koen, additional, Van Esbroeck, Marjan, additional, Van Dijck, Christophe, additional, Brosius, Isabel, additional, Van den Bossche, Dorien, additional, Florence, Eric, additional, van Griensven, Johan, additional, Bottieau, Emmanuel, additional, Soentjens, Patrick, additional, Berens-Riha, Nicole, additional, Vanbaelen, Thibaut, additional, Van Frankenhuijsen, Maartje, additional, Vandenbruaene, Marc, additional, Huyst, Veerle, additional, Wouters, Kristien, additional, Apers, Ludwig, additional, Kint, Ilse, additional, Caluwaerts, Séverine, additional, and Coppens, Jasmine, additional

Published
2022
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17. Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Hardt, Karin, primary, Vandebosch, An, additional, Sadoff, Jerald, additional, Le Gars, Mathieu, additional, Truyers, Carla, additional, Lowson, David, additional, Van Dromme, Ilse, additional, Vingerhoets, Johan, additional, Kamphuis, Tobias, additional, Scheper, Gert, additional, Ruiz-Guiñazú, Javier, additional, Faust, Saul N, additional, Spinner, Christoph D, additional, Schuitemaker, Hanneke, additional, Van Hoof, Johan, additional, Douoguih, Macaya, additional, Struyf, Frank, additional, Garibaldi, Brian T., additional, Albertson, Timothy E., additional, Sandrock, Christian, additional, Lee, Janet S., additional, Looney, Mark R., additional, Tapson, Victor F., additional, Wiysonge, Charles Shey, additional, Velarde, Luis Humberto Anaya, additional, Backenroth, Daniel, additional, Bhushanan, Jisha, additional, Brandenburg, Börries, additional, Cárdenas, Vicky, additional, Chen, Bohang, additional, Chen, Fei, additional, Chetty, Polan, additional, Chu, Pei-Ling, additional, Cooper, Kimberly, additional, Custers, Jerome, additional, Delanghe, Hilde, additional, Duca, Anna, additional, Henrick, Tracy, additional, Juraszek, Jarek, additional, Nalpas, Catherine, additional, Peeters, Monika, additional, Pinheiro, Jose, additional, Roels, Sanne, additional, Ryser, Martin F., additional, Salas, Jose, additional, Santoro Matias, Samantha, additional, Scheys, Ilse, additional, Shetty, Pallavi, additional, Shukarev, Georgi, additional, Stoddard, Jeffrey, additional, Talloen, Willem, additional, Tran, NamPhuong, additional, Vaissiere, Nathalie, additional, van Son-Palmen, Elisabeth, additional, Xu, Jiajun, additional, Goecker, Erin A., additional, Greninger, Alexander L., additional, Jerome, Keith R., additional, Roychoudhury, Pavitra, additional, Takuva, Simbarashe G., additional, Accini Mendoza, Jose Luis, additional, Achtyes, Eric, additional, Ahsan, Habibul, additional, Alhatemi, Azhar, additional, Allen, Nancy, additional, Arribas, Jose R., additional, Bahrami, Ghazaleh, additional, Bailon, Lucia, additional, Bajwa, Ali, additional, Baker, Jonathan, additional, Baron, Mira, additional, Benet, Susana, additional, Berdaï, Driss, additional, Berger, Patrick, additional, Bertoch, Todd, additional, Bethune, Claire, additional, Bevilacqua, Sybille, additional, Biagioni Santos, Maria Silvia, additional, Binnian, Ian, additional, Bisnauthsing, Karen, additional, Boivin, Jean-Marc, additional, Bollen, Hilde, additional, Bonnet, Sandrine, additional, Borobia, Alberto M., additional, Botelho-Nevers, Elisabeth, additional, Bright, Phil, additional, Britten, Vianne, additional, Brown, Claire, additional, Buadi, Amanda, additional, Buntinx, Erik, additional, Burgess, Lesley, additional, Bush, Larry, additional, Capeding, Maria Rosario, additional, Carr, Quito Osuna, additional, Carrasco Mas, Amparo, additional, Catala, Hélène, additional, Cathie, Katrina, additional, Caudill, T. Shawn, additional, Cereto Castro, Fernando, additional, Chau, Kénora, additional, Chavoustie, Steven, additional, Chowdhury, Marie, additional, Chronos, Nicolas, additional, Cicconi, Paola, additional, Cifuentes, Liliana, additional, Cobo, Sara Maria, additional, Collins, Helen, additional, Colton, Hayley, additional, Cuaño, Carlos Rolando G., additional, D'Onofrio, Valentino, additional, Dargan, Paul, additional, Darton, Thomas, additional, Deane, Peter, additional, Del Pozo, Jose Luis, additional, Derdelinckx, Inge, additional, Desai, Amisha, additional, Dever, Michael, additional, Díaz-Pollán, Beatriz, additional, DiBuono, Mark, additional, Doust, Matthew, additional, Duncan, Christopher, additional, Echave-Sustaeta, Jose Maria, additional, Eder, Frank, additional, Ellis, Kimberly, additional, Elzi, Stanton, additional, Emmett, Stevan, additional, Engelbrecht, Johannes, additional, Evans, Mim, additional, Farah, Theo, additional, Felton, Timothy, additional, Ferreira, João Pedro, additional, Floutier, Catherine, additional, Flume, Patrick, additional, Ford, Stacy, additional, Fragoso, Veronica, additional, Freedman, Andrew, additional, Frentiu, Emilia, additional, Galloway, Christopher, additional, Galtier, Florence, additional, Garcia Diaz, Julia, additional, García García, Irene, additional, Garcia, Alcaide, additional, Gardener, Zoe, additional, Gauteul, Pascale, additional, Geller, Steven, additional, Gibson, Andrew, additional, Gillet, Claudia, additional, Girerd, Nicolas, additional, Girodet, Pierre-Olivier, additional, Gler, Maria Tarcela, additional, Glover, Richard, additional, Go, Herschel Don D., additional, Gokani, Karishma, additional, Gonthier, Damien, additional, Green, Christopher, additional, Greenberg, Richard, additional, Griffin, Carl, additional, Grobbelaar, Coert, additional, Guancia, Adonis, additional, Hakkarainen, Gloria, additional, Harris, James, additional, Hassman, Michael, additional, Heimer, Deirdre, additional, Hellstrom-Louw, Elizabeth, additional, Herades, Yoan, additional, Holroyd, Christopher, additional, Hussen, Nazreen, additional, Isidro, Marie Grace Dawn, additional, Jackson, Yvonne, additional, Jain, Manish, additional, João Filho, Esaú Custódio, additional, Johnson, Daniel, additional, Jones, Ben, additional, Joseph, Natasha, additional, Jumeras, Analyn, additional, Junquera, Patricia, additional, Kellett-Wright, Johanna, additional, Kennedy, Patrick, additional, Kilgore, Paul E., additional, Kim, Kenneth, additional, Kimmel, Murray, additional, Konis, George, additional, Kutner, Mark, additional, Lacombe, Karine, additional, Launay, Odile, additional, Lazarus, Rajeka, additional, Lederman, Samuel, additional, Lefebvre, Gigi, additional, Lennon Collins, Katrina, additional, Leroux-Roels, Isabel, additional, Lim, Kenneth Wilson O., additional, Lins, Muriel, additional, Liu, Edward, additional, Llewelyn, Martin, additional, Mahomed, Akbar, additional, Maia, Bernardo Porto, additional, Marín-Candon, Alícia, additional, Martínez-Gómez, Xavier, additional, Martinot, Jean Benoit, additional, Mazzella, Andrea, additional, McCaughan, Frank, additional, McCormack, Louise, additional, McGettigan, John, additional, Mehra, Purvi, additional, Mejeur, Rhonda, additional, Miller, Vicki, additional, Mills, Anthony, additional, Molto Marhuenda, Jose, additional, Moodley, Prebashan, additional, Mora-Rillo, Marta, additional, Mothe, Beatriz, additional, Mullan, Daniel, additional, Munro, Alasdair, additional, Myers, Paul, additional, Nell, Jeremy, additional, Newman Lobato Souza, Tamara, additional, O'Halloran, Jane A., additional, Ochoa Mazarro, Maria Dolores, additional, Oliver, Abigail, additional, Onate Gutierrez, Jose Millan, additional, Ortega, Jessica, additional, Oshita, Masaru, additional, Otero Romero, Susana, additional, Overcash, Jeffrey Scott, additional, Owens, Daniel, additional, Packham, Alice, additional, Pacurar, Mihaela, additional, Paiva de Sousa, Leonardo, additional, Palfreeman, Adrian, additional, Pallares, Christian José, additional, Patel, Rahul, additional, Patel, Suchet, additional, Pelkey, Leslie, additional, Peluso, Denise, additional, Penciu, Florentina, additional, Pinto, S. Jerry, additional, Pounds, Kevin, additional, Pouzar, Joe, additional, Pragalos, Antoinette, additional, Presti, Rachel, additional, Price, David, additional, Qureshi, Ehsaan, additional, Ramalho Madruga, José Valdez, additional, Ramesh, Mayur, additional, Rankin, Bruce, additional, Razat, Béatrice, additional, Riegel Santos, Breno, additional, Riesenberg, Robert, additional, Riffer, Ernie, additional, Roche, Siobhan, additional, Rose, Katie, additional, Rosellini, Pietro, additional, Rossignol, Patrick, additional, Safirstein, Beth, additional, Salazar, Hernan, additional, Sanchez Vallejo, Gregorio, additional, Santhosh, Smrithi, additional, Seco-Meseguer, Enrique, additional, Seep, Michael, additional, Sherry, Emma, additional, Short, Philip, additional, Soentjens, Patrick, additional, Solis, Joel, additional, Soriano Viladomiu, Alejandro, additional, Sorli, Caroline, additional, Spangenthal, Selwyn, additional, Spence, Niamh, additional, Stephenson, Elaine, additional, Strout, Cynthia, additional, Surowitz, Ronald, additional, Taladua, Kristy Michelle, additional, Tellalian, David, additional, Thalamas, Claire, additional, Thiriphoo, Nang, additional, Thomas, Judith, additional, Thomas, Nicholas, additional, Trout, Guillermo, additional, Urroz, Mikel, additional, Veekmans, Bernard, additional, Veekmans, Laurent, additional, Villalobos, Ralph Elvi M., additional, Warren, Sarah, additional, Webster, Brian, additional, White, Alexander, additional, Williams, Gail, additional, Williams, Hayes, additional, Wilson, Barbara, additional, Winston, Alan, additional, Wiselka, Martin, additional, and Zervos, Marcus, additional

Published
2022
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18. Severe mpox (formerly monkeypox) disease in five patients after recent vaccination with MVA-BN vaccine, Belgium, July to October 2022

Author

Berens-Riha, Nicole, De Block, Tessa, Rutgers, Jojanneke, Michiels, Johan, Van Gestel, Liesbeth, Hens, Matilde, Kenyon, Chris, Bottieau, Emmanuel, Soentjens, Patrick, van Griensven, Johan, Brosius, Isabel, Arien, Kevin K, Van Esbroeck, Marjan, Rezende, Antonio Mauro, Vercauteren, Koen, and Liesenborghs, Laurens

Subjects
Science & Technology, Infectious Diseases, Epidemiology, Virology, Public Health, Environmental and Occupational Health, ANKARA, Life Sciences & Biomedicine
Abstract

Vaccination is important in containing the 2022 mpox (formerly monkeypox) epidemic. We describe five Belgian patients with localised severe symptoms of proctitis and penile oedema, occurring between 4 and 35 days after post-exposure preventive vaccination or after one- or two-dose off-label pre-exposure preventive vaccination with MVA-BN vaccine. Genome sequencing did not reveal evidence for immune escape variants. Healthcare workers and those at risk should be aware of possible infections occurring shortly after vaccination and the need for other preventive measures. ispartof: EUROSURVEILLANCE vol:27 issue:48 ispartof: location:Sweden status: published

Published
2022

19. Alternative sampling specimens for the molecular detection of mpox (formerly monkeypox) virus

Author

Van Dijck, Christophe, Ramadan, Kadrie, Van Looveren, Karin, Baeyens, Jolien, Van Hoyweghen, Cindy, Mangelschots, Marianne, Coppens, Sandra, Heyndrickx, Leo, Michiels, Johan, De Block, Tessa, Laga, Marie, Vanhamel, Jef, Vuylsteke, Bea, Bottieau, Emmanuel, Vandenhove, Leen, Selhorst, Philippe, Rezende, Antonio Mauro, Smet, Hilde, Rasson, Hanne, Verschueren, Jacob, Platteau, Tom, Hauner, Anne, Willems, Betty, Coppens, Jasmine, Vanroye, Fien, Brosius, Isabel, Liesenborghs, Laurens, van Henten, Saskia, Vanbaelen, Thibaut, Bracke, Stefanie, Berens-Riha, Nicole, De Baetselier, Irith, Kenyon, Chris, Soentjens, Patrick, Florence, Eric, Van Griensven, Johan, Ariën, Kevin K., Jacobs, Bart K.M., Van den Bossche, Dorien, Van Esbroeck, Marjan, and Vercauteren, Koen

Published
2023
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21. Presymptomatic viral shedding in high‐risk mpox contacts: A prospective cohort study.

Author

Brosius, Isabel, Dijck, Christophe Van, Coppens, Jasmine, Vandenhove, Leen, Bangwen, Eugene, Vanroye, Fien, Verschueren, Jacob, Zange, Sabine, Bugert, Joachim, Michiels, Johan, Bottieau, Emmanuel, Soentjens, Patrick, van Griensven, Johan, Kenyon, Chris, Ariën, Kevin K., Esbroeck, Marjan Van, Vercauteren, Koen, and Liesenborghs, Laurens

Subjects
MONKEYPOX, VIRAL shedding, COHORT analysis, VIRAL DNA, LONGITUDINAL method
Abstract

The risk of infection after exposure to clade IIb mpox virus (MPXV) is unknown, and potential presymptomatic shedding of MPXV remains to be demonstrated. High‐risk contacts of mpox patients were followed‐up in a prospective longitudinal cohort study. Individuals reporting sexual contact, >15 min skin‐to‐skin contact, or living in the same household with an mpox patient were recruited in a sexual health clinic in Antwerp, Belgium. Participants kept a symptom diary, performed daily self‐sampling (anorectal, genital, and saliva), and presented for weekly clinic visits for physical examination and sampling (blood and oropharyngeal). Samples were tested for MPXV by PCR. Between June 24 and July 31, 2022, 25 contacts were included, of which 12/18 (66.0%) sexual and 1/7 (14.0%) nonsexual contacts showed evidence of infection by MPXV‐PCR. Six cases had typical mpox symptoms. Viral DNA was detected as early as 4 days before symptom onset in 5 of them. In 3 of these cases, replication‐competent virus was demonstrated in the presymptomatic phase. These findings confirm the existence of presymptomatic shedding of replication‐competent MPXV and emphasize the high risk of transmission during sexual contact. Sexual contacts of mpox cases should abstain from sex during the incubation period, irrespective of symptoms. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Phage therapy to allow liver transplantation in a toddler infected by an extensively drug-resistant Pseudomonas aeruginosa

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - (SLuc) Service de pédiatrie générale, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Van Nieuwenhuyse, Brieuc, van Der Linden, Dimitri, Chatzis, Olga, Lood, Cedric, Wagemans, Jeroen, Lavigne, Rob, de Magnee, Catherine, Sokal, Etienne, Rodriguez-Villalobos, Hector, Djebara, Sarah, Soentjens, Patrick, Pirnay, Jean-Paul, International Pediatric Transplant Association, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - (SLuc) Service de pédiatrie générale, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Van Nieuwenhuyse, Brieuc, van Der Linden, Dimitri, Chatzis, Olga, Lood, Cedric, Wagemans, Jeroen, Lavigne, Rob, de Magnee, Catherine, Sokal, Etienne, Rodriguez-Villalobos, Hector, Djebara, Sarah, Soentjens, Patrick, Pirnay, Jean-Paul, and International Pediatric Transplant Association

Abstract

Brieuc Van Nieuwenhuyse1, Dimitri Van der Linden1,2, Olga Chatzis2, Cédric Lood3,4, Jeroen Wagemans3, Rob Lavigne4, Catherine de Magnée5, Étienne Sokal1,6, Hector Rodriguez-Villalobos7, Sarah Djebara8, Maya Merabishvili9, Patrick Soentjens8, Jean-Paul Pirnay9. 1Institute of Experimental and Clinical Research's Pediatric department, UCLouvain, Brussels, Belgium; 2Pediatric Infectious Diseases, General Pediatrics Department, Cliniques universitaires Saint-Luc, Brussels, Belgium; 3Department of Biosystems, Laboratory of Gene Technology, KULeuven, Leuven, Belgium; 4Department of Microbial and Molecular Systems, Centre of Microbial and Plant Genetics, KULeuven, Leuven, Belgium; 5Pediatric and Transplantation Surgery, Cliniques universitaires Saint-Luc, Brussels, Belgium; 6Pediatric Hepatology and Gastro-enterology, Cliniques universitaires Saint-Luc, Brussels, Belgium; 7Department of Microbiology, Cliniques universitaires Saint-Luc, Brussels, Belgium; 8Center for Infectious Diseases, Queen Astrid Military Hospital, Brussels, Belgium; 9Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium A 14-month old boy undergoes a first liver transplantation (LT) (Day 0), from an ABO-incompatible living donor. On D+20, we detect a fecal carriage of an extensively drug-resistant (XDR) Pseudomonas aeruginosa (Pa) strain. Besides intermediate susceptibility to aztreonam and colistin and susceptibility to gentamycin, the strain is resistant to all other antibiotics. On D+53, the child enters a severe septic state due to a bacteremia with the same Pa strain. New antibiogram suggests a resistance to colistin. Liver bilomas' drainage material is cultured and grows the same Pa strain. Admission to the pediatric intensive care unit and adjunction of intravenous (IV) aztreonam, gentamycin, and colistin led to no improvement on the microbiological or clinical levels during the next four days. By collaborating with Queen Astrid Military Hospital (Bru

Published
2022

23. Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler.

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de pédiatrie générale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Van Nieuwenhuyse, Brieuc, Van der Linden, Dimitri, Chatzis, Olga, Lood, Cédric, Wagemans, Jeroen, Lavigne, Rob, Schroven, Kaat, Paeshuyse, Jan, De Magnee, Catherine, Sokal, Etienne, Stéphenne, Xavier, Scheers, Isabelle, Rodriguez-Villalobos, Hector, Djebara, Sarah, Merabishvili, Maya, Soentjens, Patrick, Pirnay, Jean-Paul, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de pédiatrie générale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Van Nieuwenhuyse, Brieuc, Van der Linden, Dimitri, Chatzis, Olga, Lood, Cédric, Wagemans, Jeroen, Lavigne, Rob, Schroven, Kaat, Paeshuyse, Jan, De Magnee, Catherine, Sokal, Etienne, Stéphenne, Xavier, Scheers, Isabelle, Rodriguez-Villalobos, Hector, Djebara, Sarah, Merabishvili, Maya, Soentjens, Patrick, and Pirnay, Jean-Paul

Abstract

Post-operative bacterial infections are a leading cause of mortality and morbidity after ongoing liver transplantation. Bacteria causing these infections in the hospital setting can exhibit high degrees of resistance to multiple types of antibiotics, which leads to major therapeutic hurdles. Alternate ways of treating these antibiotic-resistant infections are thus urgently needed. Phage therapy is one of them and consists in using selected bacteriophage viruses - viruses who specifically prey on bacteria, naturally found in various environmental samples - as bactericidal agents in replacement or in combination with antibiotics. The use of phage therapy raises various research questions to further characterize what determines therapeutic success or failure. In this work, we report the story of a toddler who suffered from extensively drug-resistant Pseudomonas aeruginosa sepsis after liver transplantation. He was treated by a bacteriophage-antibiotic intravenous combination therapy for 86 days. This salvage therapy was well tolerated, without antibody-mediated phage neutralization. It was associated with objective clinical and microbiological improvement, eventually allowing for liver retransplantation and complete resolution of all infections. Clear in vitro phage-antibiotic synergies were observed. The occurrence of bacterial phage resistance did not result in therapeutic failure, possibly due to phage-induced virulence tradeoffs, which we investigated in different experimental models.

Published
2022

25. Phage therapy to allow liver transplantation in a toddler infected by an extensively drug-resistant Pseudomonas aeruginosa

Author

Van Nieuwenhuyse, Brieuc, van Der Linden, Dimitri, Chatzis, Olga, Lood, Cedric, Wagemans, Jeroen, Lavigne, Rob, de Magnee, Catherine, Sokal, Etienne, Rodriguez-Villalobos, Hector, Djebara, Sarah, Soentjens, Patrick, Pirnay, Jean-Paul, International Pediatric Transplant Association, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de gastro-entérologie et hépatologie pédiatrique, UCL - (SLuc) Service de pédiatrie générale, and UCL - (SLuc) Service de chirurgie et transplantation abdominale

Abstract

Brieuc Van Nieuwenhuyse1, Dimitri Van der Linden1,2, Olga Chatzis2, Cédric Lood3,4, Jeroen Wagemans3, Rob Lavigne4, Catherine de Magnée5, Étienne Sokal1,6, Hector Rodriguez-Villalobos7, Sarah Djebara8, Maya Merabishvili9, Patrick Soentjens8, Jean-Paul Pirnay9. 1Institute of Experimental and Clinical Research's Pediatric department, UCLouvain, Brussels, Belgium; 2Pediatric Infectious Diseases, General Pediatrics Department, Cliniques universitaires Saint-Luc, Brussels, Belgium; 3Department of Biosystems, Laboratory of Gene Technology, KULeuven, Leuven, Belgium; 4Department of Microbial and Molecular Systems, Centre of Microbial and Plant Genetics, KULeuven, Leuven, Belgium; 5Pediatric and Transplantation Surgery, Cliniques universitaires Saint-Luc, Brussels, Belgium; 6Pediatric Hepatology and Gastro-enterology, Cliniques universitaires Saint-Luc, Brussels, Belgium; 7Department of Microbiology, Cliniques universitaires Saint-Luc, Brussels, Belgium; 8Center for Infectious Diseases, Queen Astrid Military Hospital, Brussels, Belgium; 9Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium A 14-month old boy undergoes a first liver transplantation (LT) (Day 0), from an ABO-incompatible living donor. On D+20, we detect a fecal carriage of an extensively drug-resistant (XDR) Pseudomonas aeruginosa (Pa) strain. Besides intermediate susceptibility to aztreonam and colistin and susceptibility to gentamycin, the strain is resistant to all other antibiotics. On D+53, the child enters a severe septic state due to a bacteremia with the same Pa strain. New antibiogram suggests a resistance to colistin. Liver bilomas' drainage material is cultured and grows the same Pa strain. Admission to the pediatric intensive care unit and adjunction of intravenous (IV) aztreonam, gentamycin, and colistin led to no improvement on the microbiological or clinical levels during the next four days. By collaborating with Queen Astrid Military Hospital (Brussels, Belgium), we initiated phage therapy (PT) on D+57 in accordance to the Article 37 of the Declaration of Helsinki and with the patient's parents' consent. PT is the use of lytic bacteriophage viruses to achieve antibacterial effect. Phage cocktail BFC1 contains two anti-Pa phages (PNM and 14/1) and one anti-Staphylococcus aureus phage (ISP). BFC1 was administered in situ by instillations through biliary catheter during six days, and in IV for 86 days (72 days until 2nd LT, 14 days afterwards), the longest described duration for IV PT in a child. Previous antibiotic therapy was pursued all along. Intraoperative PT was performed during 2nd LT by bathing the peritoneal cavity in phage solution during the anhepatic phase. To further our understanding of the case, seven Pa isolates, both bloodborne and liver-borne, were sequenced. Serum samples obtained before, during, and after phage therapy were analyzed through double agar overlay method to search for phage immune neutralization (PIN). Phage-induced virulence tradeoffs (PIVT) assays were performed in a Galleria mellonella model. In vitro phage-antibiotic interactions were evaluated with OmniLog® system. PT initiation was followed by immediate (

Published
2022

27. Asymptomatic Monkeypox Virus Infections Among Male Sexual Health Clinic Attendees in Belgium

Author

De Baetselier, Irith, primary, Van Dijck, Christophe, additional, Kenyon, Chris, additional, Coppens, Jasmine, additional, Van den Bossche, Dorien, additional, Smet, Hilde, additional, Vanroye, Fien, additional, Liesenborghs, Laurens, additional, Ramadan, Kadrie, additional, Platteau, Tom, additional, Van Looveren, Karin, additional, Baeyens, Jolien, additional, Van Hoyweghen, Cindy, additional, Mangelschots, Marjan, additional, Coppens, Sandra, additional, Heyndrickx, Leo, additional, Michiels, Johan, additional, De Block, Tessa, additional, Manoharan-Basil, Sheeba, additional, Brosius, Isabel, additional, Ariën, Kevin K., additional, Van Griensven, Johan, additional, Laga, Marie, additional, Vanhamel, Jef, additional, Vuylsteke, Bea, additional, Bottieau, Emmanuel, additional, Soentjens, Patrick, additional, Florence, Eric, additional, Vercauteren, Koen, additional, and Van Esbroeck, Marjan, additional

Published
2022
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28. Evaluating Diagnostic Accuracy of Saliva Sampling Methods for Severe Acute Respiratory Syndrome Coronavirus 2 Reveals Differential Sensitivity and Association with Viral Load

Author

Mestdagh, Pieter, primary, Gillard, Michel, additional, Dhillon, Sharonjit K., additional, Pirnay, Jean-Paul, additional, Poels, Jeroen, additional, Hellemans, Jan, additional, Hutse, Veronik, additional, Vermeiren, Celine, additional, Boutier, Maxime, additional, De Wever, Veerle, additional, Soentjens, Patrick, additional, Djebara, Sarah, additional, Malonne, Hugues, additional, André, Emmanuel, additional, Arbyn, Marc, additional, Smeraglia, John, additional, and Vandesompele, Jo, additional

Published
2021
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29. Human Filariasis in Travelers and Migrants: A Retrospective 25-year Analysis at the Institute of Tropical Medicine, Antwerp, Belgium

Author

Bottieau, Emmanuel, primary, Huits, Ralph, additional, Van Den Broucke, Steven, additional, Maniewski, Ula, additional, Declercq, Steven, additional, Brosius, Isabel, additional, Theunissen, Caroline, additional, Feyens, Anne-Marie, additional, Van Esbroeck, Marjan, additional, van Griensven, Johan, additional, Clerinx, Jan, additional, and Soentjens, Patrick, additional

Published
2021
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30. Variant Analysis of SARS-CoV-2 Genomes from Belgian Military Personnel Engaged in Overseas Missions and Operations

Author

Pirnay, Jean-Paul, primary, Selhorst, Philippe, additional, Hong, Samuel L., additional, Cochez, Christel, additional, Potter, Barney, additional, Maes, Piet, additional, Petrillo, Mauro, additional, Dudas, Gytis, additional, Claes, Vincent, additional, Van der Beken, Yolien, additional, Verbeken, Gilbert, additional, Degueldre, Julie, additional, Dellicour, Simon, additional, Cuypers, Lize, additional, T’Sas, France, additional, Van den Eede, Guy, additional, Verhasselt, Bruno, additional, Weuts, Wouter, additional, Smets, Cedric, additional, Mertens, Jan, additional, Geeraerts, Philippe, additional, Ariën, Kevin K., additional, André, Emmanuel, additional, Neirinckx, Pierre, additional, Soentjens, Patrick, additional, and Baele, Guy, additional

Published
2021
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31. Evaluating Diagnostic Accuracy of Saliva Sampling Methods for Severe Acute Respiratory Syndrome Coronavirus 2 Reveals Differential Sensitivity and Association with Viral Load

Author

Berke, Peter, Díez, Pedro, Gualandi, Stefano, Marino, Michele, Gerard, Pierre, Marconi, Stefania, Mestdagh, Pieter, Gillard, Michel, Dhillon, Sharonjit S.K., Pirnay, Jean-Paul, Poels, Jeroen, Hellemans, Jan, Hutse, Veronik, Vermeiren, Céline, Boutier, Maxime, De Wever, Veerle, Soentjens, Patrick, Djebara, Sarah, Malonne, Hugues, André, Emmanuel, Arbyn, Marc, Smeraglia, John, Vandesompele, Jo, Berke, Peter, Díez, Pedro, Gualandi, Stefano, Marino, Michele, Gerard, Pierre, Marconi, Stefania, Mestdagh, Pieter, Gillard, Michel, Dhillon, Sharonjit S.K., Pirnay, Jean-Paul, Poels, Jeroen, Hellemans, Jan, Hutse, Veronik, Vermeiren, Céline, Boutier, Maxime, De Wever, Veerle, Soentjens, Patrick, Djebara, Sarah, Malonne, Hugues, André, Emmanuel, Arbyn, Marc, Smeraglia, John, and Vandesompele, Jo

Abstract

Nasopharyngeal swabs are considered the preferential collection method for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostics. Less invasive and simpler alternative sampling procedures, such as saliva collection, are desirable. We compared saliva specimens and nasopharyngeal (NP) swabs with respect to sensitivity in detecting SARS-CoV-2. A nasopharyngeal and two saliva specimens (collected by spitting or oral swabbing) were obtained from >2500 individuals. All samples were tested by RT-qPCR, detecting RNA of SARS-CoV-2. The test sensitivity was compared on the two saliva collections with the nasopharyngeal specimen for all subjects and stratified by symptom status and viral load. Of the 2850 patients for whom all three samples were available, 105 were positive on NP swab, whereas 32 and 23 were also positive on saliva spitting and saliva swabbing samples, respectively. The sensitivity of the RT-qPCR to detect SARS-CoV-2 among NP-positive patients was 30.5% (95% CI, 1.9%–40.2%) for saliva spitting and 21.9% (95% CI, 14.4%–31.0%) for saliva swabbing. However, when focusing on subjects with medium to high viral load, sensitivity on saliva increased substantially: 93.9% (95% CI, 79.8%–99.3%) and 76.9% (95% CI, 56.4%–91.0%) for spitting and swabbing, respectively, regardless of symptomatic status. Our results suggest that saliva cannot readily replace nasopharyngeal sampling for SARS-CoV-2 diagnostics but may enable identification of the most contagious cases with medium to high viral loads., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

32. A cluster of plasmodium ovale infections in belgian military personnel after deployment in kindu, democratic republic of congo:A retrospective study

Author

Strachinaru, Diana Isabela Costescu, Wauters, An, Van Esbroeck, Marjan, Strachinaru, Mihai, Vanbrabant, Peter, Soentjens, Patrick, Strachinaru, Diana Isabela Costescu, Wauters, An, Van Esbroeck, Marjan, Strachinaru, Mihai, Vanbrabant, Peter, and Soentjens, Patrick

Abstract

Plasmodium ovale malaria is often neglected due to its less severe course compared to Plasmodium falciparum. In 2011–2012, Belgian Armed Forces identified a cluster of P. ovale cases among military personnel after deployment in the Democratic Republic of Congo (DRC). In this retrospective, monocentric, observational study, clinical and biological features of soldiers diagnosed with P. ovale after deployment in DRC were reviewed. Species diagnosis was based on polymerase chain reaction (PCR) and/or thick blood smear. Medical records of 149 soldiers screened at the Queen Astrid Military Hospital after deployment were reviewed. Eight cases (seven P. ovale infections and one P. ovale—falciparum coinfection) were identified. All had positive thick smears, and seven were confirmed by PCR. Chemoprophylaxis was mefloquine in all subjects. Median time of disease onset was 101 days after return from the endemic region. Median delay between return and diagnosis was 103 days. All P. ovale bouts were uncomplicated. None had relapses after primaquine treatment. This military cohort highlights a hotspot of P. ovale in Eastern DRC. Non-specific symptoms, the less severe presentation, the lack of sensitive parasitological tools in the field and long delays between infection and symptoms probably lead to underestimation of P. ovale cases.

Published
2021

33. Diagnosis of Mycobacterium marinum infection with sporotrichoid pattern

Author

Costescu Strachinaru, Diana Isabela, Vanbrabant, Peter, Stinga, Patricia, Strachinaru, Mihai, Soentjens, Patrick, Costescu Strachinaru, Diana Isabela, Vanbrabant, Peter, Stinga, Patricia, Strachinaru, Mihai, and Soentjens, Patrick

Abstract

SCOPUS: ar.j, DecretOANoAutActif, info:eu-repo/semantics/published

Published
2021

34. Variant analysis of SARS-CoV-2 genomes from belgian military personnel engaged in overseas missions and operations

Author

Pirnay, Jean-Paul, Selhorst, Philippe, Hong, Samuel S.L., Cochez, Christel, Potter, Barney, Maes, Piet, Petrillo, Mauro, Dudas, Gytis, Claes, Vincent, Van der Beken, Yolien, Verbeken, Gilbert, Degueldre, Julie, Dellicour, Simon, Cuypers, Lize, T’sas, France, Van Den Eede, Guy, Verhasselt, Bruno, Weuts, Wouter, Smets, Cedric, Mertens, Jan, Geeraerts, Philippe, Ariën, Kevin, André, Emmanuel, Neirinckx, Pierre, Soentjens, Patrick, Baele, Guy, Pirnay, Jean-Paul, Selhorst, Philippe, Hong, Samuel S.L., Cochez, Christel, Potter, Barney, Maes, Piet, Petrillo, Mauro, Dudas, Gytis, Claes, Vincent, Van der Beken, Yolien, Verbeken, Gilbert, Degueldre, Julie, Dellicour, Simon, Cuypers, Lize, T’sas, France, Van Den Eede, Guy, Verhasselt, Bruno, Weuts, Wouter, Smets, Cedric, Mertens, Jan, Geeraerts, Philippe, Ariën, Kevin, André, Emmanuel, Neirinckx, Pierre, Soentjens, Patrick, and Baele, Guy

Abstract

More than a year after the first identification of severe acute respiratory syndrome coron-avirus 2 (SARS-CoV-2) as the causative agent of the 2019 coronavirus disease (COVID-19) in China, the emergence and spread of genomic variants of this virus through travel raise concerns regarding the introduction of lineages in previously unaffected regions, requiring adequate containment strate-gies. Concomitantly, such introductions fuel worries about a possible increase in transmissibility and disease severity, as well as a possible decrease in vaccine efficacy. Military personnel are frequently deployed on missions around the world. As part of a COVID-19 risk mitigation strategy, Belgian Armed Forces that engaged in missions and operations abroad were screened (7683 RT-qPCR tests), pre-and post-mission, for the presence of SARS-CoV-2, including the identification of viral lineages. Nine distinct viral genotypes were identified in soldiers returning from operations in Niger, the Democratic Republic of the Congo, Afghanistan, and Mali. The SARS-CoV-2 variants belonged to major clades 19B, 20A, and 20B (Nextstrain nomenclature), and included “variant of interest” B.1.525, “variant under monitoring” A.27, as well as lineages B.1.214, B.1, B.1.1.254, and A (pangolin nomenclature), some of which are internationally monitored due to the specific mutations they har-bor. Through contact tracing and phylogenetic analysis, we show that isolation and testing policies implemented by the Belgian military command appear to have been successful in containing the influx and transmission of these distinct SARS-CoV-2 variants into military and civilian populations., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

40. Human Filariasis in Travelers and Migrants: A Retrospective 25-year Analysis at the Institute of Tropical Medicine, Antwerp, Belgium.

Author

Bottieau, Emmanuel, Huits, Ralph, Broucke, Steven Van Den, Maniewski, Ula, Declercq, Steven, Brosius, Isabel, Theunissen, Caroline, Feyens, Anne-Marie, Esbroeck, Marjan Van, Griensven, Johan van, Clerinx, Jan, and Soentjens, Patrick

Subjects
NOMADS, PARASITOLOGY, RETROSPECTIVE studies, ACQUISITION of data, TREATMENT effectiveness, FILARIASIS, MEDICAL records, DESCRIPTIVE statistics, TRAVEL hygiene, SYMPTOMS
Abstract

Background Information on human filariasis in international travelers is scarce. We describe the epidemiology, clinical presentation, and outcome of these infections in a reference travel clinic over the past decades. Methods We reviewed all cases of filariasis diagnosed at the Institute of Tropical Medicine, Antwerp, Belgium, from 1994 to 2018. Diagnosis was obtained by either parasitological methods (confirmed) or strict clinical case definitions (probable). We assessed the characteristics of cases at diagnosis and response to therapy within 3–12 months. Results A total of 320 patients (median age: 41 years; 71% males) were diagnosed with 327 filarial infections (Wuchereria bancrofti = 6, Onchocerca volvulus = 33, Loa loa = 150, Mansonella perstans = 130, unspecified species = 8). Diagnosis was confirmed in 213/320 (67%) patients. European long-term travelers accounted for 166 patients (52%) and visitors/migrants from tropical countries for another 110 (34%). Central Africa was the likely region of acquisition for 294 (92%) patients. The number of filariasis cases decreased from 21.5/year on average in the 1990s to 6.3/year in the past decade, when loiasis became predominant. Cases reported symptoms in >80% of all filarial infections but mansonellosis (45/123 single infections; 37%). Lymphatic filariasis and onchocerciasis cases responded well to conventional therapy. However, 30% of patients with loiasis and mansonellosis experienced treatment failure (with diethylcarbamazine and levamisole-mebendazole, respectively). Conclusions The burden and species distribution of filariasis in travelers evolved in the past decades. Most presentations were symptomatic. Case management would benefit from more effective therapies for loiasis and mansonellosis. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Epidemiology and etiology of blood stream infections in a Belgian burn wound center

Author

Costescu Strachinaru, Diana Isabela, primary, Gallez, Jean-Luc, additional, François, Pierre-Michel, additional, Baekelandt, Dries, additional, Paridaens, Marie-Sophie, additional, Pirnay, Jean-Paul, additional, De Vos, Daniel, additional, Djebara, Sarah, additional, Vanbrabant, Peter, additional, Strachinaru, Mihai, additional, and Soentjens, Patrick, additional

Published
2021
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45. Simplifying rabies vaccination schedules

Author

Soentjens, Patrick, Bottieau, Emmanuel, and van Damme, Pierre

Abstract

Shortened and simpler rabies PrEP and PEP ID schedules, using low-dose vaccine volumes can be considered as a good illustration of ‘less can be more’. The story of a first successful post-exposure treatment against rabies by Josef Meister, who was bitten by a rabid dog, was performed by Louis Pasteur in 1885. This treatment, which comprised 13 injections given over 9 days ended with the injection of a fully virulent virus. Today, the new post-exposure prophylaxis (PEP) recommended by World Health Organization (WHO) can be simplified to a total of six intradermal micro-injections (one dose of 0.1 mL in two separate arms) divided over 3 days in one week (day 0, day 3 and day 7). Our team evaluated shortened combined pre-exposure prophylaxis (PrEP) and PEP schedules over 3 days and 2 days in two randomised clinical trials, of which an adapted version is now promoted by WHO as first-line PrEP and PEP over in total 3 days. Bringing the rabies prevention schedule 134 years later from nine visits to three or to two assures clinical effectiveness of this regimen with a safer profile, better compliance, and drastically simplifies rabies prevention procedures for the traveller.

Published
2020

46. Screening the asymptomatic soldiers after a stay in sub-Saharan Africa. A retrospective observational study

Author

Vanbrabant, Peter, Damanet, Benjamin, Maussen, Christiane, Van-Esbroeck, Marjan, Soentjens, Patrick, Vanbrabant, Peter, Damanet, Benjamin, Maussen, Christiane, Van-Esbroeck, Marjan, and Soentjens, Patrick

Abstract

Background: Many tropical clinics offer post-travel screening for parasitic infections in asymptomatic travellers. However, literature on attack rates and incidence rates of parasitic infections is scarce. Method: All military personnel returning from a tropical region during the year 2018 were tested for the presence of antibodies against Strongyloides stercoralis, Schistosoma and Entamoeba histolytica. Test results were compared with previous results if available to distinguish recent and old infection. Results: In total, 949 soldiers were included in the study. The median age was years 31 (IQR: 26–41), 96.3% were male. The median duration of stay in the tropics was 35 days (IQR: 14–90). The destination was predominantly central Africa. Serological tests were positive for S. stercoralis in 10 patients (1.1%), Schistosoma in 3 (0.3%), and E. histolytica in 16 (1.7%). The attack rates were 0.84, 0.32 and 1.69 respectively. The incidence rates were 3.99, 1.49 and 7.97 respectively. Conclusions: The risk for parasitic infection in the asymptomatic returning soldiers is low. However, the potentially serious complications of unrecognised parasitic infection can legitimise systematic screening., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

47. Factors influencing the immune response after a single-dose 3-visit pre-exposure rabies intradermal vaccination schedule: A retrospective multivariate analysis

Author

Damanet, Benjamin, Strachinaru, Diana Isabela Costescu, Van Nieuwenhove, Mathias MDM, Soentjens, Patrick, Damanet, Benjamin, Strachinaru, Diana Isabela Costescu, Van Nieuwenhove, Mathias MDM, and Soentjens, Patrick

Abstract

Background: The World Health Organization (WHO) recommends intradermal (ID) rabies vaccination as a safe and immunogenic alternative to intramuscular administration. The aim of this study is to determine which factors influence the levels of rabies virus neutralizing antibodies (RVNA) after a 3-visit ID rabies vaccination. Methods: This is a retrospective secondary data analysis study based on electronic health record vaccination data of Belgian military subjects who received ID rabies Pre-exposure prophylaxis (PrEP) with a single-dose 3-visit regimen during the period 2014–2017. Logistic regression was performed to identify predictive factors of RVNA level ≥3.0 IU/mL and >10 IU/mL. Results: The second analysis performed on the 2025 subjects (100% seroconverted with a RVNA ≥ 0.5 IU/mL) shows a significantly better immune response in subjects younger than 30 years compared to all other age-groups, a gender-difference to predict RVNA ≥ 3.0 IU/mL (OR 2.30 [1.26–4.22] comparing “female” to “male”) and the influence of the vaccination schedule (OR 2.28 [1.15–4.53] comparing “late - very variable” to “correct” schedule) to predict > 10 IU/ml. Multivariate analysis also demonstrates that a postponed serology control significantly influences the Rapid Fluorescent Focus Inhibition Test (RFFIT). Conclusion: Gender and age significantly influence the response to ID rabies vaccine. Timing of RVNA determination is important to correctly assess the response to vaccination. A single-dose 3-visit ID rabies PrEP schedule is a dose-sparing effective alternative to the double-dose 2-visit ID schedule. When the minimum time interval between doses is respected, RVNA determination is not necessary., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

48. Factors influencing the immune response after a double-dose 2-visit pre-exposure rabies intradermal vaccination schedule: A retrospective study

Author

Damanet, Benjamin, Costescu Strachinaru, Diana Isabela, Soentjens, Patrick, Damanet, Benjamin, Costescu Strachinaru, Diana Isabela, and Soentjens, Patrick

Abstract

Background: Double-dose 2-visit intradermal rabies schedules (22ID) have recently been accepted by the World Health Organization (WHO) as Pre-Exposure Prophylaxis (PrEP). The aim of this study is to determine which factors influence the levels of rabies virus neutralizing antibodies (RVNA) after a 22ID rabies vaccination schedule. Methods: This is a retrospective study based on electronic health record vaccination data of subjects from the Belgian Armed Forces who received the 22ID rabies PrEP. An antibody titer ≥0.5 IU/mL, measured by rapid fluorescent focus inhibition test, is defined by the WHO as an adequate immune response after PrEP. Logistic regression was performed in order to identify predictive factors of RVNA level ≥3.0 IU/ml and >10 IU/ml. Results: 301 subjects were included. 297 (98,6%) seroconverted with a RVNA ≥ 0.5 IU/ml. Multivariate analysis shows a significant better immune response in the subjects where the second dose was administered later on than on day 7 (RVNA >10 IU/ml (OR: 3.01 [1.36–6.67])). Postponing the timing of the serology control also influenced significantly the rapid fluorescent focus inhibition test (RVNA ≥ 3.0 IU/ml (OR: 0.12 [0.06–0.24]) and RVNA > 10 IU/ml (OR: 0.14 [0.06–0.29])). Conclusion: A 22ID rabies PrEP vaccination schedule is highly effective and provides an adequate immune response in most subjects in a real live setting. Timing of the second vaccine dose significantly influences the response to ID rabies vaccine. Timing of RVNA determination is important in order to correctly assess the response to vaccination., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2020

50. Evaluation of saliva sampling procedures for SARS-CoV-2 diagnostics reveals differential sensitivity and association with viral load

Author

Mestdagh, Pieter, primary, Gillard, Michel, additional, Arbyn, Marc, additional, Pirnay, Jean-Paul, additional, Poels, Jeroen, additional, Hellemans, Jan, additional, Peeters, Eliana, additional, Hutse, Veronik, additional, Vermeiren, Celine, additional, Boutier, Maxime, additional, De Wever, Veerle, additional, Soentjens, Patrick, additional, Djebara, Sarah, additional, Malonne, Hugues, additional, André, Emmanuel, additional, Smeraglia, John, additional, and Vandesompele, Jo, additional

Published
2020
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