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1. Formation and evolution of carbonaceous asteroid Ryugu: Direct evidence from returned samples

Author

Nakamura, T., primary, Matsumoto, M., additional, Amano, K., additional, Enokido, Y., additional, Zolensky, M. E., additional, Mikouchi, T., additional, Genda, H., additional, Tanaka, S., additional, Zolotov, M. Y., additional, Kurosawa, K., additional, Wakita, S., additional, Hyodo, R., additional, Nagano, H., additional, Nakashima, D., additional, Takahashi, Y., additional, Fujioka, Y., additional, Kikuiri, M., additional, Kagawa, E., additional, Matsuoka, M., additional, Brearley, A. J., additional, Tsuchiyama, A., additional, Uesugi, M., additional, Matsuno, J., additional, Kimura, Y., additional, Sato, M., additional, Milliken, R. E., additional, Tatsumi, E., additional, Sugita, S., additional, Hiroi, T., additional, Kitazato, K., additional, Brownlee, D., additional, Joswiak, D. J., additional, Takahashi, M., additional, Ninomiya, K., additional, Takahashi, T., additional, Osawa, T., additional, Terada, K., additional, Brenker, F. E., additional, Tkalcec, B. J., additional, Vincze, L., additional, Brunetto, R., additional, Aléon-Toppani, A., additional, Chan, Q. H. S., additional, Roskosz, M., additional, Viennet, J.-C., additional, Beck, P., additional, Alp, E. E., additional, Michikami, T., additional, Nagaashi, Y., additional, Tsuji, T., additional, Ino, Y., additional, Martinez, J., additional, Han, J., additional, Dolocan, A., additional, Bodnar, R. J., additional, Tanaka, M., additional, Yoshida, H., additional, Sugiyama, K., additional, King, A. J., additional, Fukushi, K., additional, Suga, H., additional, Yamashita, S., additional, Kawai, T., additional, Inoue, K., additional, Nakato, A., additional, Noguchi, T., additional, Vilas, F., additional, Hendrix, A. R., additional, Jaramillo-Correa, C., additional, Domingue, D. L., additional, Dominguez, G., additional, Gainsforth, Z., additional, Engrand, C., additional, Duprat, J., additional, Russell, S. S., additional, Bonato, E., additional, Ma, C., additional, Kawamoto, T., additional, Wada, T., additional, Watanabe, S., additional, Endo, R., additional, Enju, S., additional, Riu, L., additional, Rubino, S., additional, Tack, P., additional, Takeshita, S., additional, Takeichi, Y., additional, Takeuchi, A., additional, Takigawa, A., additional, Takir, D., additional, Tanigaki, T., additional, Taniguchi, A., additional, Tsukamoto, K., additional, Yagi, T., additional, Yamada, S., additional, Yamamoto, K., additional, Yamashita, Y., additional, Yasutake, M., additional, Uesugi, K., additional, Umegaki, I., additional, Chiu, I., additional, Ishizaki, T., additional, Okumura, S., additional, Palomba, E., additional, Pilorget, C., additional, Potin, S. M., additional, Alasli, A., additional, Anada, S., additional, Araki, Y., additional, Sakatani, N., additional, Schultz, C., additional, Sekizawa, O., additional, Sitzman, S. D., additional, Sugiura, K., additional, Sun, M., additional, Dartois, E., additional, De Pauw, E., additional, Dionnet, Z., additional, Djouadi, Z., additional, Falkenberg, G., additional, Fujita, R., additional, Fukuma, T., additional, Gearba, I. R., additional, Hagiya, K., additional, Hu, M. Y., additional, Kato, T., additional, Kawamura, T., additional, Kimura, M., additional, Kubo, M. K., additional, Langenhorst, F., additional, Lantz, C., additional, Lavina, B., additional, Lindner, M., additional, Zhao, J., additional, Vekemans, B., additional, Baklouti, D., additional, Bazi, B., additional, Borondics, F., additional, Nagasawa, S., additional, Nishiyama, G., additional, Nitta, K., additional, Mathurin, J., additional, Matsumoto, T., additional, Mitsukawa, I., additional, Miura, H., additional, Miyake, A., additional, Miyake, Y., additional, Yurimoto, H., additional, Okazaki, R., additional, Yabuta, H., additional, Naraoka, H., additional, Sakamoto, K., additional, Tachibana, S., additional, Connolly, H. C., additional, Lauretta, D. S., additional, Yoshitake, M., additional, Yoshikawa, M., additional, Yoshikawa, K., additional, Yoshihara, K., additional, Yokota, Y., additional, Yogata, K., additional, Yano, H., additional, Yamamoto, Y., additional, Yamamoto, D., additional, Yamada, M., additional, Yamada, T., additional, Yada, T., additional, Wada, K., additional, Usui, T., additional, Tsukizaki, R., additional, Terui, F., additional, Takeuchi, H., additional, Takei, Y., additional, Iwamae, A., additional, Soejima, H., additional, Shirai, K., additional, Shimaki, Y., additional, Senshu, H., additional, Sawada, H., additional, Saiki, T., additional, Ozaki, M., additional, Ono, G., additional, Okada, T., additional, Ogawa, N., additional, Ogawa, K., additional, Noguchi, R., additional, Noda, H., additional, Nishimura, M., additional, Namiki, N., additional, Nakazawa, S., additional, Morota, T., additional, Miyazaki, A., additional, Miura, A., additional, Mimasu, Y., additional, Matsumoto, K., additional, Kumagai, K., additional, Kouyama, T., additional, Kikuchi, S., additional, Kawahara, K., additional, Kameda, S., additional, Iwata, T., additional, Ishihara, Y., additional, Ishiguro, M., additional, Ikeda, H., additional, Hosoda, S., additional, Honda, R., additional, Honda, C., additional, Hitomi, Y., additional, Hirata, N., additional, Hayashi, T., additional, Hayakawa, M., additional, Hatakeda, K., additional, Furuya, S., additional, Fukai, R., additional, Fujii, A., additional, Cho, Y., additional, Arakawa, M., additional, Abe, M., additional, and Tsuda, Y., additional

Published
2023
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12. Japan's rail system: fast track to future

Author

Soejima, H.

Subjects
Japan -- Transportation, High speed trains -- Innovations, Environmental issues, Government, Petroleum, energy and mining industries, Science and technology
Abstract

The Central Japan Railway Company developed a new version of bullet train called Nozomi Series 300, which is a significant contribution to the fast and high-quality railway service in Japan. The high speed rail has been operating for more them 30 years without a single accident. It consists of Automatic Train Control, Centralized Traffic Control, a multipurpose inspection train, a clearance confirmation car and a fail-safe system which ensure its safety. The new model incorporates many improvements over the earlier models.

Published
1994

15. Autosomal recessive cystinuria caused by genome‐wide paternal uniparental isodisomy in a patient with Beckwith–Wiedemann syndrome

Author

Ohtsuka, Y., primary, Higashimoto, K., additional, Sasaki, K., additional, Jozaki, K., additional, Yoshinaga, H., additional, Okamoto, N., additional, Takama, Y., additional, Kubota, A., additional, Nakayama, M., additional, Yatsuki, H., additional, Nishioka, K., additional, Joh, K., additional, Mukai, T., additional, Yoshiura, K.‐i., additional, and Soejima, H., additional

Published
2014
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16. A novelde novopoint mutation of the OCT-binding site in theIGF2/H19-imprinting control region in a Beckwith-Wiedemann syndrome patient

Author

Higashimoto, K., primary, Jozaki, K., additional, Kosho, T., additional, Matsubara, K., additional, Fuke, T., additional, Yamada, D., additional, Yatsuki, H., additional, Maeda, T., additional, Ohtsuka, Y., additional, Nishioka, K., additional, Joh, K., additional, Koseki, H., additional, Ogata, T., additional, and Soejima, H., additional

Published
2013
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17. Applications of polymer brushes to structural nano-coatings

Author

Kobayashi, M., primary, Mitamura, K., additional, Terada, M., additional, Kikuchi, M., additional, Murakami, D., additional, Yamaguchi, H., additional, Arita, H., additional, Ishikawa, T., additional, Terayama, Y., additional, Soejima, H., additional, and Takahara, A., additional

Published
2011
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19. A novel de novo point mutation of the OCT-binding site in the IGF2/ H19-imprinting control region in a Beckwith-Wiedemann syndrome patient.

Author

Higashimoto, K., Jozaki, K., Kosho, T., Matsubara, K., Fuke, T., Yamada, D., Yatsuki, H., Maeda, T., Ohtsuka, Y., Nishioka, K., Joh, K., Koseki, H., Ogata, T., and Soejima, H.

Subjects
BECKWITH-Wiedemann syndrome, GENETIC mutation, GENOMIC imprinting, PROTEIN binding, METHYLATION
Abstract

The IGF2/ H19-imprinting control region ( ICR1) functions as an insulator to methylation-sensitive binding of CTCF protein, and regulates imprinted expression of IGF2 and H19 in a parental origin-specific manner. ICR1 methylation defects cause abnormal expression of imprinted genes, leading to Beckwith-Wiedemann syndrome ( BWS) or Silver-Russell syndrome ( SRS). Not only ICR1 microdeletions involving the CTCF-binding site, but also point mutations and a small deletion of the OCT-binding site have been shown to trigger methylation defects in BWS. Here, mutational analysis of ICR1 in 11 BWS and 12 SRS patients with ICR1 methylation defects revealed a novel de novo point mutation of the OCT-binding site on the maternal allele in one BWS patient. In BWS, all reported mutations and the small deletion of the OCT-binding site, including our case, have occurred within repeat A2. These findings indicate that the OCT-binding site is important for maintaining an unmethylated status of maternal ICR1 in early embryogenesis. [ABSTRACT FROM AUTHOR]

Published
2014
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24. PROGRESS REPORT OF INITIAL DESCRIPTION OF INDIVIDUAL RYUGU PARTICLES RETURNED BY HAYABUSA2.

Author

Yada, T., Abe, M., Yogata, K., Miyazaki, A., Nagashima, K., Nakato, A., Hatakeda, K., Hitomi, Y., Sugiyama, Y., Nishimura, M., Sakamoto, K., Kanemaru, R., Kumagai, K., Soejima, H., Okada, T., Fukai, R., Ishizaki, T., Sugahara, H., Suzuki, S., and Sugita, S.

Subjects
VISIBLE spectra, COMPUTED tomography, LIGHT filters, NEAR-earth asteroids, ELECTRON microscopes, OPTICAL spectra, OPTICAL microscopes, INFRARED absorption
Abstract

Introduction: Hayabusa2 spacecraft returned samples from near-Earth C-type asteroid 162173 Ryugu to the Earth on 6 Dec. 2020 [1]. Since the samples had been returned, we continue describing individual Ryugu particles for their images, weights, visible and infrared spectra with the optical microscope Nikon SMZ1270i, the balance Mettler-Toledo XP404s, the monochronic digital microscope Kiralux CS895MU with six-bands filters for incident light, the FT-IR Jasco VIR-300 and the infrared microscope MicrOmega, respectively [1, 2]. So far, 404 individual Ryugu particles have been handpicked and described for all or some of the methods [3-11]. Surface morphologies and bulk densities of individual Ryugu particles: As mentioned in [3, 4], individual Ryugu particles have been grouped into angular or rounded in their shapes and smooth and rough in their morprologues. In total, those having rounded-shape (59%) and rough-surface (80%) are dominant in them. The relationship with their optical morphologies and surface mineralogizes were confirmed for the four individual Ryugu particles with an electron microscope [12], indicating those showing smooth surfaces showing space-weathering features on their surfaces. Although it is still poor in statistics, surface morphologies might reflect their mineralogical feature such as space weathering. Bulk densities of individual Ryugu particles were calculated based on the volume estimated from their three-dimensional size and to be 1283 ± 231 kg m-3 in an average of 156 individual Ryugu particles [1]. All the bulk densities of 404 individual Ryugu particles were plotted in the viewgraph of [4], showing the same tendency as reported in [1]. As pointed before, individual Ryugu particles vary from 500 to 2500 kg m-3 in bulk densities, indicating their porosities should vary largely from particles to particles, or errors in volume estimation are large [8]. More accurate volume evaluation such as three-dimensional imaging [8] or X-ray computed tomography [13] should be applied more for individual Ryugu particles to reveal their "real" bulk and grain densities. Infrared and visible reflectance spectra of individual Ryugu particles: So far, 244 of individual Ryugu particles have been analyzed for their infrared reflectance spectra with the FT-IR. 2.7µm absorption, corresponding to presence of -OH, have been detected from all of them, indicating ubiquitous presence of hydrous minerals in Ryugu samples. 3.4 µm absorption features, corresponding to presence of carbonate or -CH, have been detected from 48% of them. As pointed before [3], this should be partially due to their heterogeneous distribution of carbonate and/or organic components in them, and that the spectral feature in 3.4 µm is much weaker than 2.7 µm. It is difficult to detect spectral feature other than 2.7 µm for the particle comparable to or smaller than effective beam size of FT-IR, ~2 mm. The MicrOmega will help to detect minor spectral features from such small particles, even though there is limitation of number of analyses per day (2 individual particles per day). Visible spectra of individual Ryugu samples have been also analyzed with the digital microscope of muti-band filters [7]. The average spectrum of 69 individual Ryugu particles are comparable to that of bulk Ryugu samples, indicating there is no spectrally different particle among them. Due to the schedule of analyses, not all of the individual Ryugu particles have been analyzed for the visible spectra, but we should proceed the analysis to understand overall spectral features of Ryugu samples. Ryugu sample database and international announcement of opportunity (AO) for Ryugu samples: All the obtained initial description data shown above is open in public by the Ryugu Sample Database System (https://darts.isas.jaxa.jp/curation/hayabusa2/) [14]. The first international AO is ongoing based on this database, and the samples will be distributed to principal investigators of selected research proposals from this June (see detail in https://jaxa-ryugu-sample-ao.net/). Additionally, the second AO will be released in this summer. [ABSTRACT FROM AUTHOR]

Published
2022

34. Erratum

Author

Saito, H., primary, Nishikawa, A., additional, Gu, J.G., additional, Ihara, Y., additional, Soejima, H., additional, Wada, Y., additional, Sekiya, C., additional, Niikawa, N., additional, and Taniguchi, N., additional

Published
1994
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42. Differential effect of low-dose aspirin for primary prevention of atherosclerotic events in diabetes management: a subanalysis of the JPAD trial.

Author

Okada S, Morimoto T, Ogawa H, Kanauchi M, Nakayama M, Uemura S, Doi N, Jinnouchi H, Waki M, Soejima H, Sakuma M, Saito Y, Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes Trial Investigators, Okada, Sadanori, Morimoto, Takeshi, Ogawa, Hisao, Kanauchi, Masao, Nakayama, Masafumi, Uemura, Shiro, and Doi, Naofumi

Abstract

Objective: Recent reports showed that low-dose aspirin was ineffective in the primary prevention of cardiovascular events in diabetic patients overall. We hypothesized that low-dose aspirin would be beneficial in patients receiving insulin therapy, as a high-risk group.Research Design and Methods: This study is a subanalysis of the Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) trial-a randomized, controlled, open-label trial. We randomly assigned 2,539 patients with type 2 diabetes and no previous cardiovascular disease to the low-dose aspirin group (81 or 100 mg daily) or to the no-aspirin group. The median follow-up period was 4.4 years. We investigated the effect of low-dose aspirin on preventing atherosclerotic events in groups receiving different diabetes management.Results: At baseline, 326 patients were treated with insulin, 1,750 with oral hypoglycemic agents (OHAs), and 463 with diet alone. The insulin group had the longest history of diabetes, the worst glycemic control, and the highest prevalence of diabetic microangiopathies. The diet-alone group had the opposite characteristics. The incidence of atherosclerotic events was 26.6, 14.6, and 10.4 cases per 1,000 person-years in the insulin, OHA, and diet-alone groups, respectively. In the insulin and OHA groups, low-dose aspirin did not affect atherosclerotic events (insulin: hazard ratio [HR] 1.19 [95% CI 0.60-2.40]; OHA: HR 0.84 [0.57-1.24]). In the diet-alone group, low-dose aspirin significantly reduced atherosclerotic events, despite the lowest event rates (HR 0.21 [0.05-0.64]).Conclusions: Low-dose aspirin reduced atherosclerotic events predominantly in the diet-alone group and not in the insulin or OHA groups. [ABSTRACT FROM AUTHOR]

Published
2011
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43. Low-dose aspirin therapy in patients with type 2 diabetes and reduced glomerular filtration rate: subanalysis from the JPAD trial.

Author

Saito Y, Morimoto T, Ogawa H, Nakayama M, Uemura S, Doi N, Jinnouchi H, Waki M, Soejima H, Sugiyama S, Okada S, Akai Y, Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes Trial Investigators, Saito, Yoshihiko, Morimoto, Takeshi, Ogawa, Hisao, Nakayama, Masafumi, Uemura, Shiro, Doi, Naofumi, and Jinnouchi, Hideaki

Abstract

Objective: Type 2 diabetes accompanied by renal damage is a strong risk factor for atherosclerotic events. The purpose of this study was to investigate the efficacy of low-dose aspirin therapy on primary prevention of atherosclerotic events in patients with type 2 diabetes and coexisting renal dysfunction.Research Design and Methods: The Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) trial was a prospective, randomized, open-label trial conducted throughout Japan that enrolled 2,539 type 2 diabetic patients without a history of atherosclerotic diseases. Patients were assigned to the aspirin group (81 mg/day or 100 mg/day) or the nonaspirin group and followed for a median of 4.37 years. The primary end points were atherosclerotic events of fatal and nonfatal ischemic heart disease, stroke, and peripheral arterial disease.Results: The analysis included 2,523 patients who had serum creatinine measured. In 1,373 patients with baseline estimated glomerular filtration rate (eGFR) 60-89 mL/min/1.73 m(2), the incidence of primary end points was significantly lower in the aspirin group than in the nonaspirin group (aspirin, 30/661; nonaspirin, 55/712; hazard ratio 0.57 [95% CI 0.36-0.88]; P = 0.011). Low-dose aspirin therapy did not reduce primary end points in patients with eGFR ≥ 90 mL/min/1.73 m(2) (aspirin, 9/248; nonaspirin, 11/270; 0.94 [0.38-2.3]) or those with eGFR <60 mL/min/1.73 m(2) (aspirin, 29/342; nonaspirin, 19/290; 1.3 [0.76-2.4]). The Cox proportional hazard model demonstrated a significant interaction between mild renal dysfunction (eGFR 60-89 mL/min/1.73 m(2)) and aspirin (P = 0.02).Conclusions: These results suggest a differential effect of low-dose aspirin therapy in diabetic patients with eGFR 60-89 mL/min/1.73 m(2). [ABSTRACT FROM AUTHOR]

Published
2011
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