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32 results on '"Soejarto, Djaja Doel"'

2. Discovery of Anticancer Agents of Diverse Natural Origin

Author

Aldrich, Leslie N., primary, Burdette, Joanna E., additional, Carcache de Blanco, Esperanza, additional, Coss, Christopher C., additional, Eustaquio, Alessandra S., additional, Fuchs, James R., additional, Kinghorn, A. Douglas, additional, MacFarlane, Amanda, additional, Mize, Brittney K., additional, Oberlies, Nicholas H., additional, Orjala, Jimmy, additional, Pearce, Cedric J., additional, Phelps, Mitch A., additional, Rakotondraibe, Liva Harinantenaina, additional, Ren, Yulin, additional, Soejarto, Djaja Doel, additional, Stockwell, Brent R., additional, Yalowich, Jack C., additional, and Zhang, Xiaoli, additional

Published
2022
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5. Novel Strategies for the Discovery of Plant-Derived Anticancer Agents

Author

Cordell, Geoffrey A., primary, Farnsworth, Norman R., additional, Beecher, Christopher W. W., additional, Soejarto, Djaja Doel, additional, Kinghorn, A. Douglas, additional, Pezzuto, John M., additional, Wall, Monroe E., additional, Wani, Mansukh C., additional, Brown, Daniel M., additional, O'Neill, Melanie J., additional, Lewis, Jane A., additional, Tait, R. Murray, additional, and Harris, Timothy J. R., additional

Published
1993
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7. Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species#.

Author

Agarwal, Garima, Chang, Long-Sheng, Soejarto, Djaja Doel, and Kinghorn, A. Douglas

Subjects
THERAPEUTIC use of antineoplastic agents, DIBENZOFURANS, HETEROCYCLIC compounds, ANTIVIRAL agents, PHYTOCHEMICALS, HYDROCARBONS, TRANSFERASES, PLANT extracts, MOLECULAR structure, METABOLITES
Abstract

With about 120 species, Aglaia is one of the largest genera of the plant family Meliaceae (the mahogany plants). It is native to the tropical rainforests of the Indo-Australian region, ranging from India and Sri Lanka eastward to Polynesia and Micronesia. Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties, with the cyclopenta[ b ]benzofurans (rocaglates or flavaglines) being of particular interest. Phytochemists, medicinal chemists, and biologists have conducted extensive research in establishing these secondary metabolites as potential lead compounds with antineoplastic and antiviral effects, among others. The varied biological properties of rocaglates can be attributed to their unusual structures and their ability to act as inhibitors of the eukaryotic translation initiation factor 4A (eIF4A), affecting protein translation. The present review provides an update on the recently reported phytochemical constituents of Aglaia species, focusing on rocaglate derivatives. Furthermore, laboratory work performed on investigating the biological activities of these chemical constituents is also covered. [ABSTRACT FROM AUTHOR]

Published
2021
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8. Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species#.

Author

Agarwal, Garima, Chang, Long-Sheng, Soejarto, Djaja Doel, and Kinghorn, A. Douglas

Subjects
PROTEINS, MEDICINAL plants, BIOLOGICAL products, HETEROCYCLIC compounds, ANTINEOPLASTIC agents, ANTIVIRAL agents, PHYTOCHEMICALS, TRANSFERASES, MOLECULAR structure
Abstract

With about 120 species, Aglaia is one of the largest genera of the plant family Meliaceae (the mahogany plants). It is native to the tropical rainforests of the Indo-Australian region, ranging from India and Sri Lanka eastward to Polynesia and Micronesia. Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties, with the cyclopenta[ b ]benzofurans (rocaglates or flavaglines) being of particular interest. Phytochemists, medicinal chemists, and biologists have conducted extensive research in establishing these secondary metabolites as potential lead compounds with antineoplastic and antiviral effects, among others. The varied biological properties of rocaglates can be attributed to their unusual structures and their ability to act as inhibitors of the eukaryotic translation initiation factor 4A (eIF4A), affecting protein translation. The present review provides an update on the recently reported phytochemical constituents of Aglaia species, focusing on rocaglate derivatives. Furthermore, laboratory work performed on investigating the biological activities of these chemical constituents is also covered. [ABSTRACT FROM AUTHOR]

Published
2021
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10. Bioassay‐Guided Isolation and Structural Modification of the Anti‐TB Resorcinols from Ardisia gigantifolia

Author

Guan, Yi‐Fu, primary, Song, Xun, additional, Qiu, Ming‐Hua, additional, Luo, Shi‐Hong, additional, Wang, Bao‐Jie, additional, Van Hung, Nguyen, additional, Cuong, Nguyen M., additional, Soejarto, Djaja Doel, additional, Fong, Harry H.S., additional, Franzblau, Scott G., additional, Li, Sheng‐Hong, additional, He, Zhen‐Dan, additional, and Zhang, Hong‐Jie, additional

Published
2016
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12. Litsea Species as Potential Antiviral Plant Sources

Author

Guan, Yifu, primary, Wang, Dongying, additional, Tan, Ghee T., additional, Van Hung, Nguyen, additional, Cuong, Nguyen Manh, additional, Pezzuto, John M., additional, Fong, Harry H.S., additional, Soejarto, Djaja Doel, additional, and Zhang, Hongjie, additional

Published
2016
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13. Estrogenic and serotonergic butenolides from the leaves of Piper hispidum Swingle (Piperaceae)

Author

Michel, Joanna L., Chen, Yegao, Zhang, Hongjie, Huang, Yue, Krunic, Aleksej, Orjala, Jimmy, Veliz, Mario, Soni, Kapil K., Soejarto, Djaja Doel, Caceres, Armando, and Pérez Sánchez, Alice Lorena

Subjects
Serotonin agonist, Piper hispidum, Maya, 9,10-Methylenedioxy-5,6-Z-fadyenolide, Butenolides, Estrogen agonist
Abstract

Publisher copyright policies & self-archiving: Author's Pre-print: author can archive pre-print (ie pre-refereeing). Author's Post-print: author can archive post-print (ie final draft post-refereeing). Publisher's Version/PDF: author cannot archive publisher's version/PDF. Documento privado Ethnopharmacological relevance: Our previous work has demonstrated that several plants in the Piperaceae family are commonly used by the Q’eqchi Maya of Livingston, Guatemala to treat amenorrhea, dysmenorrhea, and pain. Extracts of Piper hispidum Swingle (Piperaceae), bound to the estrogen (ER) and serotonin (5-HT7) receptors. Aim of the study: To investigate the estrogenic and serotonergic activities of Piper hispidum extracts in functionalized assays, identify the active chemical constituents in the leaf extract, and test these compounds as agonists or antagonists of ER and 5-HT7. Materials and methods: The effects of the Piper hispidum leaf extracts were investigated in estrogen reporter gene and endogenous gene assays in MCF-7 cells to determine if the extracts acted as an estrogen agonist or antagonist. In addition, the active compounds were isolated using ER- and 5-HT7 receptor bioassay-guided fractionation. The structures of the purified compounds were identified using highresolution LC–MS and NMR spectroscopic methods. The ER- and 5-HT7-agonist effects of the purified chemical constituents were tested in a 2ERE-reporter gene assay in MCF-7 cells and in serotonin binding and functionalized assays. Results: Three butenolides including one new compound (1) were isolated from the leaves of Piper hispidum, and their structures were determined. Compound 1 bound to the serotonin receptor 5-HT7 with IC50 values of 16.1 and 8.3 ␮M, respectively, and using GTP shift assays, Compound 1 was found to be a partial agonist of the 5-HT7 receptor. The Piper hispidum leaf extracts, as well as Compounds 2 and 3 enhanced the expression of estrogen responsive reporter and endogenous genes in MCF-7 cells, demonstrating estrogen agonist effects. Conclusions: Extracts of Piper hispidum act as agonists of the ER and 5-HT7 receptors. Compound 1, a new natural product, identified as 9,10-methylenedioxy-5,6-Z-fadyenolide, was isolated as the 5-HT7 agonist. Compounds 2 and 3 are reported for the first time in Piper hispidum, and identified as the estrogen agonists. No inhibition of CYP450 was observed for any of these compounds in concentrations up to 1 ␮M. These activities are consistent with the Q’eqchi traditional use of the plant for the treatment of disorders associated with the female reproductive cycle. Community Health Sciences Division, School of Public Health, University of Illinois at Chicago, Chicago, IL 60612, USA. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, IL 60612, USA. Department of Chemistry, Yunnan Normal University, Kunming 650092, People’s Republic of China. Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL 60612, USA. School of Biology, Faculty of Chemical Science and Pharmacy, Universidad de San Carlos, Guatemala City, Guatemala. School of Biological Chemistry, Faculty of Pharmacy, Universidad de San Carlos, Guatemala. Centro de Investigaciones en Productos Naturales (CIPRONA), Universidad de Costa Rica, San José, Costa Rica. UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA)

Published
2010

14. Raymond Cooper: 1949 - 2022.

Author

Soejarto, Djaja Doel and Chun-Tao Che

Subjects
COLLEGE teachers, EXPERIENCE
Abstract

The article discusses Ray Cooper a natural products scientist and pharmacognosist who died on May 28, 2022 after suffering from colon cancer for five years. Topics include information on his educational life, his achievements including the Varro E. Tyler Prize from American Society of Pharmacognosy, and discovery of new antibiotics related to the monobactams.

Published
2022

15. Discovery of Bioactive Compounds by the UIC-ICBG Drug Discovery Program in the 18 Years Since 1998.

Author

Hong-Jie Zhang, Wan-Fei Li, Fong, Harry H. S., and Soejarto, Djaja Doel

Abstract

The International Cooperative Biodiversity Groups (ICBG) Program based at the University of Illinois at Chicago (UIC) is a program aimed to address the interdependent issues of inventory and conservation of biodiversity, drug discovery and sustained economic growth in both developing and developed countries. It is an interdisciplinary program involving the extensive synergies and collaborative efforts of botanists, chemists and biologists in the countries of Vietnam, Laos and the USA. The UIC-ICBG drug discovery efforts over the past 18 years have resulted in the collection of a cumulative total of more than 5500 plant samples (representing more than 2000 species), that were evaluated for their potential biological effects against cancer, HIV, bird flu, tuberculosis and malaria. The bioassay-guided fractionation and separation of the bioactive plant leads resulted in the isolation of approximately 300 compounds of varying degrees of structural complexity and/or biological activity. The present paper summarizes the significant drug discovery achievements made by the UIC-ICBG team of multidisciplinary collaborators in the project over the period of 1998–2012 and the projects carried on in the subsequent years by involving the researchers in Hong Kong. [ABSTRACT FROM AUTHOR]

Published
2016
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16. Isolation and Characterization of Minor Analogues of Silvestrol and Other Constituents from a Large-Scale Re-collection of Aglaia foveolata

Author

Pan, Li, primary, Kardono, Leonardus B. S., additional, Riswan, Soedarsono, additional, Chai, Heebyung, additional, Carcache de Blanco, Esperanza J., additional, Pannell, Caroline M., additional, Soejarto, Djaja Doel, additional, McCloud, Thomas G., additional, Newman, David J., additional, and Kinghorn, A. Douglas, additional

Published
2010
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21. “Studies on Biodiversity of Vietnam and Laos” 1998−2005: Examining the Impact

Author

Soejarto, Djaja Doel, primary, Zhang, Hong Jie, additional, Fong, Harry H. S., additional, Tan, Ghee T., additional, Ma, Cui Ying, additional, Gyllenhaal, Charlotte, additional, Riley, Mary C., additional, Kadushin, Marian R., additional, Franzblau, Scott G., additional, Bich, Truong Quang, additional, Cuong, Nguyen Manh, additional, Hiep, Nguyen Tien, additional, Loc, Phan Ke, additional, Xuan, Le Thi, additional, Hai, Nong Van, additional, Hung, Nguyen Van, additional, Chien, Nguyen Quyet, additional, Binh, Le Tran, additional, Vu, Bui Minh, additional, Ly, Ho Minh, additional, Southavong, Bounhong, additional, Sydara, Kongmany, additional, Bouamanivong, S., additional, Pezzuto, John M., additional, Rose, William C., additional, Dietzman, Gregg R., additional, Miller, Byron E., additional, and Thuy, Tran Van, additional

Published
2006
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22. Mahabir Prashad Gupta 1942 - 2021.

Author

Calderón, Angela I. and Soejarto, Djaja Doel

Subjects
PHARMACOLOGY, DIETARY supplements, TEACHERS, DRUG development
Published
2021

25. Studies On Biodiversity Of Vietnam And Laos: The UIC-based ICBG Program

Author

Soejarto, Djaja Doel, primary, Gyllenhaal, Charlotte, additional, Regalado, Jacinto, additional, Pezzuto, John, additional, Fong, Harry, additional, Tan, Ghee Teng, additional, Hiep, Nguyen Tien, additional, Xuan, Le Thi, additional, Binh, Do Quang, additional, Van Hung, Nguyen, additional, Bich, Truong Quang, additional, Thin, Nguyen Nghia, additional, Loc, Phan Ke, additional, Vu, Bui Minh, additional, Southavong, Boun Hoong, additional, Sydara, Kongmany, additional, Bouamanivong, Somsanith, additional, O'Neill, Melanie, additional, Lewis, Jane, additional, Xie, Xinmin, additional, and Dietzman, Gregg, additional

Published
1999
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28. Sources of the anti-implantation alkaloid yuehchukene in the genus Murraya

Author

Ng Kam-Hung, Zhang Hong-Ta, Li Qian, Peter G. Waterman, Kan Woei-Song, Cheng Kin-Fai, But Paul Pui-Hay, Soejarto Djaja Doel, Kong Yun-Cheung, and Yu Si-Xao

Subjects
Pharmacology, Yuehchukene, China, Plants, Medicinal, Traditional medicine, Murraya, Alkaloid, Biology, Anti implantation, biology.organism_classification, Rats, chemistry.chemical_compound, Alkaloids, chemistry, Pregnancy, Genus, Drug Discovery, Botany, Animals, Female, Embryo Implantation, Medicine, Traditional
Abstract

The genus Murraya has been widely used in traditional medicine in east Asia. In view of the recent isolation of the anti-implantation alkaloid yuehchukene from M. paniculata a search has now been made for other natural sources of this alkaloid within the genus. In this paper we report findings for nine taxa of Murraya.

Published
1986
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29. Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species#.

Author

Agarwal, Garima, Chang, Long-Sheng, Soejarto, Djaja Doel, and Kinghorn, A. Douglas

Subjects
*THERAPEUTIC use of antineoplastic agents, *DIBENZOFURANS, *HETEROCYCLIC compounds, *ANTIVIRAL agents, *PHYTOCHEMICALS, *HYDROCARBONS, *TRANSFERASES, *PLANT extracts, *MOLECULAR structure, *METABOLITES
Abstract

With about 120 species, Aglaia is one of the largest genera of the plant family Meliaceae (the mahogany plants). It is native to the tropical rainforests of the Indo-Australian region, ranging from India and Sri Lanka eastward to Polynesia and Micronesia. Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties, with the cyclopenta[ b ]benzofurans (rocaglates or flavaglines) being of particular interest. Phytochemists, medicinal chemists, and biologists have conducted extensive research in establishing these secondary metabolites as potential lead compounds with antineoplastic and antiviral effects, among others. The varied biological properties of rocaglates can be attributed to their unusual structures and their ability to act as inhibitors of the eukaryotic translation initiation factor 4A (eIF4A), affecting protein translation. The present review provides an update on the recently reported phytochemical constituents of Aglaia species, focusing on rocaglate derivatives. Furthermore, laboratory work performed on investigating the biological activities of these chemical constituents is also covered. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Caribbean Herbal Pharmacopoeia, e-Book, 2nd edition.

Author

Soejarto, Djaja Doel

Subjects
MEDICINAL plants, NONFICTION
Abstract

The article reviews the electronic book "Caribbean Herbal Pharmacopoeia," second edition, edited by Lionel Germosén-Robineau.

Published
2010

32. "Studies on biodiversity of Vietnam and Laos" 1998-2005: examining the impact.

Author

Soejarto DD, Zhang HJ, Fong HH, Tan GT, Ma CY, Gyllenhaal C, Riley MC, Kadushin MR, Franzblau SG, Bich TQ, Cuong NM, Hiep NT, Loc PK, Xuan le T, Hai NV, Hung NV, Chien NQ, Binh le T, Vu BM, Ly HM, Southavong B, Sydara K, Bouamanivong S, Pezzuto JM, Rose WC, Dietzman GR, Miller BE, and Thuy TV

Subjects
Intellectual Property, International Cooperation, Laos, Pharmacognosy organization & administration, Vietnam, Biodiversity, Biological Products, Drug Industry economics, Drug Industry legislation & jurisprudence, Drug Industry standards, Plants, Medicinal chemistry
Abstract

The impact of the University of Illinois at Chicago-based Vietnam-Laos International Cooperative Biodiversity Group (ICBG) Program "Studies on Biodiversity of Vietnam and Laos", which has been in operation for the period of 1998-2005, touches on five major areas of endeavor: (a) biodiversity inventory and conservation; (b) studies on medicinal plants; (c) drug discovery and development; (d) economic development; and (e) issues on intellectual property rights and benefit sharing in natural products drug discovery and development. Highlights are presented and the significance is discussed.

Published
2006
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