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Foliated antigorite serpentinites are contributing to seismic anisotropy in subduction zones. However, uncertainty remains regarding the development of antigorite crystal preferred orientations (CPO). This study analyzes the CPOs of antigorite and olivine in variably serpentinized samples of antigorite serpentinite from three localities in Southwest Japan, using U-stage, EBSD, and synchrotron X-rays. In all samples (010) poles show a maximum parallel to the lineation, and (001) poles concentrate normal to the foliation with a partial girdle about the lineation. (100) poles are less distinct and scatter widely. The three measurement methods give similar results, though orientation distributions from X-ray analysis which averages over larger sample volumes are more regular and weaker than U-stage and EBSD which focuses on local well-crystallized grains. In olivine-bearing serpentinite, the olivine CPO does not appear to control the antigorite CPO, though there are some topotactic relationships. The antigorite CPO formed contemporaneously with serpentinization and shear deformation. Based on our analyses, in a subduction zone mantle wedge, the (010) pole of antigorite is parallel to the direction of the subduction, and (001) lattice planes are parallel to the interface of the subducting oceanic plate. By averaging single crystal elastic properties over orientation distributions wave velocities have been calculated. Fast P velocities are parallel to the subduction direction and slow velocities are perpendicular to the subducting plate with an anisotropy of 10-15%. © 2013 Elsevier B.V.

This paper reports on the structure and performance of multichannel write and giant magnetoresistive (GMR) heads for a helical-scan tape system. The four-channel write head was fabricated with four layers stacked and shifted by a track pitch. The eight-channel read head was also stacked four layers, each of which has two spin-valve elements. The write head and read head were assembled into a commercial drive. Four channels are written in one revolution without a guard band and each of the eight channels is read, in half of the track pitch. The feasibility of a recording density over 4.3 Gb/[in.sup.2] was established, which would make possible a tape system of over 1 TB using an 8 mm cassette. Index Terms--GMR head, helical-scan tape system, ME-tape, multichannel, nontracking, spin-valve head.

The recording characteristics of Co--CoO metal evaporated (ME) tapes with a giant magnetoresistive head have been investigated. The reproduced spin-valve head output was 7.6 times that of an anisotropic magnetoresistive head at a recording wavelength of 0.4 [micro]m. We also studied the relation between the carrier-to-media noise (C/[N.sub.media]) ratio and remanent magnetization (Mr) magnetic layer thickness (t) in the ME tape. The media noise level was reduced with the decrease in Mr * t by the increase of the oxygen flow rate, whereas the C/[N.sub.media] ratio of the tape with a magnetic layer thickness of 33 nm was maximized at around 10 mA. We thus confirmed the feasibility of an areal density of 3.8 Gb/[in.sup.2] in a helical-scan tape drive system. Index Terms--Co--CoO metal evaporated tape, helical-scan system, spin-valve head.

The 190 kD (p190) and 210 kD (p210) Bcr-Abl proteins are responsible for the pathophysiology of Philadelphia chromosome (Ph)+ leukemia. We applied RNA interference (RNAi) to specific killing of p190+ cells, and determined the optimal sequences for gene silencing in the BCR, junctional and ABL regions of p190, respectively. Then, p190+ and p210+ cells were infected with lentiviral vectors encoding these shRNAs, resulting in efficient killing of p190+ cells, while p210+ cells were only sensitive to shBCR and shABL. In p190-transformed Ba/F3 cells, silencing of p190 specifically inhibited tyrosine phospohorylation of Stat5 prior to their death, but did not affect phosphorylation of Jak2, Akt or MEK1/2. In contrast, downregulation of p190 by their treatment with 17-allylamino-17-demetoxygeldanamycin (17-AAG) was associated with reduced protein levels of Jak2, Akt and MEK1/2. shRNA targeting p190 collaborated additively with imatinib and 17-AAG in growth inhibition of Ba/F3-p190wt and imatinib-resistant Ba/F3-p190Y253 H cells. Collectively, RNAi-mediated silencing of p190 is a promising option both for delineating signal transduction and for therapeutic application in 190+ leukemia.Leukemia (2008) 22, 1131–1138; doi:10.1038/leu.2008.60; published online 27 March 2008 [ABSTRACT FROM AUTHOR]