1. The Impact of Severe Acute Respiratory Syndrome Coronavirus Type 2 on Children With Liver Diseases: A Joint European Society for Pediatric Gastroenterology, Hepatology and Nutrition and Society of Pediatric Liver Transplantation Position Paper
- Author
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Steven J. Lobritto, Giuseppe Indolfi, Noelle H Ebel, Marian G. Michaels, Piotr Czubkowski, Mohit Kehar, Vicky L. Ng, Emanuele Nicastro, and Mercedes Martínez
- Subjects
medicine.medical_specialty ,Pediatrics ,medicine.medical_treatment ,MIS-C ,Liver transplantation ,Chronic liver disease ,coronavirus disease 2019 ,Internal medicine ,medicine ,Humans ,severe acute respiratory syndrome coronavirus type 2 ,Child ,Pediatric gastroenterology ,multisystem inflammatory syndrome in children ,Acute liver injury ,immunosuppression ,Society Papers ,autoimmune hepatitis ,liver transplantation ,business.industry ,SARS-CoV-2 ,Liver Diseases ,autoimmune liver disease ,Gastroenterology ,COVID-19 ,Hepatology ,medicine.disease ,Systemic Inflammatory Response Syndrome ,Pediatrics, Perinatology and Child Health ,SARS-CoV2 ,Position paper ,RNA, Viral ,Severe acute respiratory syndrome coronavirus ,business ,PIMS-TS ,Hepatic decompensation - Abstract
Children are seldom affected by severe forms of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV2) infection; however, the impact of comorbidities in the clinical presentation and outcome of SARS-CoV2 in children is poorly characterized including that of chronic liver disease (CLD) and those taking immunosuppressive medications for autoimmune liver disease or following liver transplantation (LT). Although not the main target organ, a spectrum of liver involvement has been described in children infected with SARS-CoV2 and those presenting with Multisystem Inflammatory Syndrome in Children (MIS-C). The Hepatology Committee of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the Society of Pediatric Liver Transplantation (SPLIT) present an evidence-based position paper on liver involvement in children with SARS-CoV2 infection and its impact on those with CLD as well as LT recipients. All children may exhibit acute liver injury from SARS-CoV2 infection, and those with CLD and may experience hepatic decompensation. Preventative and therapeutic measures are discussed.
- Published
- 2021