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171 results on '"Sobrinho-Simoes M"'

14. Follicular thyroid carcinoma

Author

Livolsi V, Abdulkader I, Baloch Zw, Bartolazzi A, Chan Jkc, De Lellis Ra, El-naggar Ak, Eloy C, Eng C, Fagin Ja, Ghossein Ra, Giordano Tj, Kondo T, Lloyd Rv, Mete O, Nikiforov Ye Nonaka D, Paschke R, Perren A, Rosai J, Sadow P, Schneider Ab, Sobrinho-simoes M, Tallini G, Williams Md, Livolsi, V, Abdulkader, I, Baloch, Zw, Bartolazzi, A, Chan, Jkc, De Lellis Ra, El-naggar, Ak, Eloy, C, Eng, C, Fagin, Ja, Ghossein, Ra, Giordano, Tj, Kondo, T, Lloyd, Rv, Mete, O, Nikiforov Ye Nonaka, D, Paschke, R, Perren, A, Rosai, J, Sadow, P, Schneider, Ab, Sobrinho-simoes, M, Tallini, Giovanni, and Williams, Md

Subjects
endocrine system, endocrine system diseases, thyroid, tumour, carcinoma, follicular
Abstract

Follicular thyroid carcinoma (FTC) is a thyroid malignancy arising from follicular cells in which the diagnostic nuclear features of papillary thyroid carcinoma (PTC) are lacking. The lesions are usually encapsulated and show invasive growth

Published
2017

15. Papillary thyroid carcinoma

Author

Rosai, J., Albores Saavedra, J., Sofia Asioli, Baloch, Zw, Bogdanova, T., C hen H, Delellis, Ra, Erickson, La, Fagin, Ja, Franssila, Ko, Giordano, Tj, Hay, Id, Lloyd, Rv, Mete, O., Nikiforov, Ye, Piana, S., Prasad, Ml, Sadow, P., Schneider, Ab, Soares, P., Sobrinho-Simoes, M., Vielh, P., Wenig, Bm, Rosai J, Albores Saavedra J, Asioli S, Baloch ZW, Bogdanova T, C hen H, DeLellis RA, Erickson LA, Fagin JA, Franssila KO, Giordano TJ, Hay ID, Lloyd RV, Mete O, Nikiforov YE, Piana S, Prasad ML, Sadow P, Schneider AB, Soares P, Sobrinho-simoes M, Vielh P, and Wenig BM.

Subjects
endocrine system, endocrine system diseases, thyroid, tumour, carcinoma, differentiation, papillary
Abstract

Papillary thyroid carcinoma is a malignant epithelial tumour showing evidence of follicular cell differentiation and a set of distinctive nuclear features. Papillary thyroid carcinoma is usually invasive. Papillae, invasion or cytological features of papillary thyroid carcinoma are required.

Published
2017

16. Poorly differentiated thyroid carcinoma

Author

Tallini G, Asioli S, Aubert S, Carcangiu Ml, Chernock R, Fellegara G, Ghossein Ra, Kakudo K, Livolsi V, Lloyd Rv, Matias-guiu X, Nikiforov Ye, Papotti M, Perren A, Rosai J, Sobrinho-simoes M., Lloyd RV, Osamura RY, Klöppel G, Rosai J, Tallini, Giovanni, Asioli, Sofia, Aubert, S, Carcangiu, Ml, Chernock, R, Fellegara, G, Ghossein, Ra, Kakudo, K, Livolsi, V, Lloyd, Rv, Matias-guiu, X, Nikiforov, Ye, Papotti, M, Perren, A, Rosai, J, and Sobrinho-simoes, M.

Subjects
endocrine system, thyroid, tumour, carcinoma, differentiation
Abstract

Poorly differentiated thyroid carcinoma: a follicular-cell neoplasm that shows limited evidence of follicular cell differentiation, and occupies both morphologically and behaviorally, an intermediate position between differentiated (follicular and papillary carcinomas) and anaplastic carcinoma. The diagnostic histopathologic criteria of poorly differentiated thyroid carcinoma (PDTC) have been listed in the Turin consensus proposal

Published
2017

20. Calcitonin receptor expression in medullary thyroid carcinoma

Author

Cappagli, V, Potes, CS, Ferreira, LB, Tavares, C, Eloy, C, Elisei, R, Sobrinho-Simoes, M, Wookey, PJ, Soares, P, Cappagli, V, Potes, CS, Ferreira, LB, Tavares, C, Eloy, C, Elisei, R, Sobrinho-Simoes, M, Wookey, PJ, and Soares, P

Abstract

BACKGROUND: Calcitonin expression is a well-established marker for medullary thyroid carcinoma (MTC); yet the role of calcitonin receptor (CTR), its seven-transmembrane G-protein coupled receptor, remains to be established in C-cells derived thyroid tumors. The aim of this work was to investigate CTR expression in MTC and to correlate such expression with clinicopathological features in order to evaluate its possible role as a prognostic indicator of disease aggressiveness and outcome. METHODS: Calcitonin receptor expression was analyzed in a series of 75 MTCs by immunohistochemistry, and by qPCR mRNA quantification in specimens from four patients. Statistical tests were used to evaluate the correlation between CTR expression and the clinicopathological and molecular characteristics of patients and tumors. RESULTS: Calcitonin receptor expression was detected in 62 out of 75 samples (82.7%), whereas 13 of the 75 samples (17.3%) were completely negative. CTR expression was significantly associated with expression of cytoplasmatic phosphatase and tensin homologue deleted on chromosome 10 and osteopontin, as well as with wild type RET/RAS genes and absence of tumor stroma, suggesting that CTR expression do not associate with clinicopathological signs of worse prognosis. DISCUSSION: Calcitonin receptor expression appears to be associated in MTC with more differentiated status of the neoplastic cells.

Published
2017

21. Helicobacter pylori Virulence and Interleukin-1 Polymorphisms have a Synergistic Effect in Increasing the Risk for Chronic Atrophic Gastritis and Gastric Carcinoma

Author

Figueiredo, C., Machado, J.C., Seruca, R., Caldas, C., Sousa, S., Carvalho, R., Quint, W.G., Doorn, L. van, Carneiro, F., and Sobrinho-Simoes, M.

Subjects
Helicobacter pylori -- Physiological aspects, Genetic polymorphisms -- Physiological aspects, Stomach cancer -- Risk factors, Gastritis -- Risk factors, Interleukin-1 -- Physiological aspects, Health
Abstract

C. Figueiredo [1,2] J.C. Machado [1] R. Seruca [1] C. Caldas [3] S. Sousa [1] R. Carvalho [1] W.G. Quint [2] L. van Doorn [2] F. Carneiro [1] M. Sobrinho [...]

Published
2001

24. Poorly differentiated thyroid carcinoma

Author

Sobrinho Simoes M, Albores Saavedra J, Santoro M, Volante M, Pilotti S, Carcangiu ML, Papotti M, Matias Guiu X, Guiter GE, Zakowski M, Sakamoto A., TALLINI, GIOVANNI, WORLD HEALTH ORGANIZATION CLASSIFICATION OF TUMORS, DELELLIS RA, LLOYD RV, HEITZ PU, ENG C, Sobrinho Simoes M, Albores-Saavedra J, Tallini G, Santoro M, Volante M, Pilotti S, Carcangiu ML, Papotti M, Matias-Guiu X, Guiter GE, Zakowski M, and Sakamoto A

Published
2004

26. OXPHOS dysfunction regulates integrin- 1 modifications and enhances cell motility and migration

Author

Nunes, J. B., primary, Peixoto, J., additional, Soares, P., additional, Maximo, V., additional, Carvalho, S., additional, Pinho, S. S., additional, Vieira, A. F., additional, Paredes, J., additional, Rego, A. C., additional, Ferreira, I. L., additional, Gomez-Lazaro, M., additional, Sobrinho-Simoes, M., additional, Singh, K. K., additional, and Lima, J., additional

Published
2014
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41. Biosynthetic basis of incompatible histo-blood group A antigen expression:anti-A transferase antibodies reactive with gastric cancer tissue of type O individuals

Author

David, L, Leitao, D, Sobrinho-Simoes, M, Bennett, E P, White, T, Mandel, U, Dabelsteen, Erik, Clausen, H, David, L, Leitao, D, Sobrinho-Simoes, M, Bennett, E P, White, T, Mandel, U, Dabelsteen, Erik, and Clausen, H

Abstract

The expression of incompatible A carbohydrate antigens in some adenocarcinomas may provide an explanation for the generally observed lower incidence of adenocarcinoma among types O and B versus type A individuals. The chemistry and genetic basis of incompatible A expression is largely unknown. Here, we have screened 31 cases of gastric tumors of phenotype O for the expression of blood group A gene-defined glycosyltransferase by immunohistology on frozen sections using newly developed monoclonal antibodies to the transferases. Three cases were positive, and transferase expression was confirmed by enzyme analysis of extracts from the specimens. Blood group A carbohydrate antigens were also identified immunohistologically in these three cases as well as in five other cases. Thin-layer chromatography immunostaining analysis of glycolipid extracts from the three cases did not confirm the chemical presence of A antigen. The ABO genotype of all patients was found to be OO, showing that all carried O alleles with a structural defect at nucleotide position 261 leading to a shift in the reading frame. The data suggest that incompatible A antigen expression is a result of transferase expression derived from the ABO genes.

Published
1993

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