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16. Systemic inflammation in chronic obstructive pulmonary disease: a population-based study

Author

Garcia-Rio F, Miravitlles M, Soriano JB, Muñoz L, Duran-Tauleria E, Sánchez G, Sobradillo V, Ancochea J, and EPI-SCAN Steering Committee

Subjects
macromolecular substances
Abstract

Elevated circulating levels of several inflammatory biomarkers have been described in selected patient populations with COPD, although less is known about their population-based distribution. The aims of this study were to compare the levels of several systemic biomarkers between stable COPD patients and healthy subjects from a population-based sample, and to assess their distribution according to clinical variables.

Published
2010

20. Smoking characteristics: differences in attitudes and dependence between healthy smokers and smokers with COPD.

Author

Jiménez-Ruiz CA, Masa F, Miravitlles M, Gabriel R, Viejo JL, Villasante C, Sobradillo V, IBERPOC Study Investigators, Jiménez-Ruiz, C A, Masa, F, Miravitlles, M, Gabriel, R, Viejo, J L, Villasante, C, and Sobradillo, V

Abstract

Objective: To ascertain the differences in smoking characteristics between a group of smokers with COPD and another group of healthy smokers, both of which were identified in a population-based epidemiologic study.Design and Participants: This is an epidemiologic, multicenter, population-based study conducted in seven areas of SPAIN: A total of 4,035 individuals, men and women aged 40 to 69 years, who were selected randomly from a target population of 236,412 subjects, participated in the study.Interventions: Eligible subjects answered the European Commission for Steel and Coal questionnaire. Spirometry was performed followed by a bronchodilator test when bronchial obstruction was present. The Fagerström questionnaire was used for study of the degree of physical nicotine dependence, and the Prochazka model was followed for analysis of the smoking cessation phase.Results: Of 1,023 active smokers, 153 (15%) met the criteria for COPD. Smokers with COPD were more frequently men (odds ratio [OR], 2.18; 95% confidence interval [CI], 1.21 to 3.95), were > or = 46 years of age (OR, 1.97; 95% CI, 1.18 to 3.31), had a lower educational level (OR, 1.96; 95% CI, 1.23 to 3.14), and had smoked > 30 pack-years (OR, 3.70; 95% CI, 2.42 to 5.65). Smokers with COPD showed a higher dependence on nicotine than healthy smokers (mean [+/- SD] Fagerström test score, 4.77 +/- 2.45 vs 3.15 +/- 2.38, respectively; p < 0.001) and higher concentrations of CO in exhaled air (mean concentration, 19.7 +/- 16.3 vs 15.4 +/- 12.1 ppm, respectively; p < 0.0001). Thirty-four percent of smokers with COPD and 38.5% of smokers without COPD had never tried to stop smoking.Conclusions: Smokers with COPD have higher tobacco consumption, higher dependence on nicotine, and higher concentrations of CO in exhaled air, suggesting a different pattern of cigarette smoking. Cases of COPD among smokers predominate in men and in individuals with lower educational levels. A significant proportion of smokers have never tried to stop smoking; thus, advice on cessation should be reinforced in both groups of smokers. [ABSTRACT FROM AUTHOR]

Published
2001
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24. Segundo documento de consenso sobre uso de antimicrobianos en la exacerbación de la enfermedad pulmonar obstructiva crónica

Author

Álvarez, F, primary, Bouza, E, additional, García-Rodríguez, JA, additional, Mensa, J, additional, Monsó, E, additional, Picazo, JJ, additional, Sobradillo, V, additional, Torres, A, additional, Moya Mir, M, additional, Martínez Ortiz de Zárate, M, additional, Pérez Escanilla, F, additional, Puente, T, additional, and Cañada, JL, additional

Published
2003
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26. Segundo documento de consenso sobre uso de antimicrobianos en la exacerbación de la enfermedad pulmonar obstructiva crónica

Author

Álvarez, F., primary, Bouzab, E., additional, García-Rodríguez, J.A., additional, Mensa, J., additional, Monsó, E., additional, Picazo, J.J., additional, Sobradillo, V., additional, Torres, A., additional, Moya Mir, M., additional, Martínez Ortiz de Zárate, M., additional, Pérez Escanilla, F., additional, Puente, T., additional, and Cañada, J.L., additional

Published
2003
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30. Fibras minerales artificiales y enfermedad respiratoria

Author

Sueiro, A., Sobradillo, V., Xaubet, Antoni, Álvarez, C., Serrano, E., Peña de Torres, Eduardo de la, Arroyo, C., Sueiro, A., Sobradillo, V., Xaubet, Antoni, Álvarez, C., Serrano, E., Peña de Torres, Eduardo de la, and Arroyo, C.

Abstract

Las fibras minerales artificiales (FMA) han sido manufacturadas y utilizadas por la industria desde hace muchas décadas. Incluyen basicamente tres grupos principales: lanas de aislamiento. filamentos continuos y las fibras cerámicas para actividades muy especializadas. La numerosa experiencia clinicoepidemiológica y experimental acumulada en la bibliografía médica respecto a la exposición laboral por inhalación a diferentes variedades de amianto y la aparición tardía de mesotelioma pleural (MP), carcinoma broncogénico (CH) y enfermedad pulmonar intersticial difusa (asbestosis), ha suscitado gran interés y una llamada de atención sobre los riesgos potenciales que para la salud pudieran derivarse del uso industrial de las FMA. En este sentido han sido publicados numerosos estudios sobre el riesgo potencial, a largo plazo, de las FMA, en grupos de trabajadores en zonas de manufacturación,,y utilización, con la finalidad de intentar aclarar su posible inocuidad. o los posibles efectos nocivos en la línea de los conocidos para el amianto principalmente. CH y MP.

Published
1996

43. Broncografías en la hemoptisis

Author

Capelastegui, A., primary, Esteban, C., additional, Ramos, J., additional, López Ruiz, J.A., additional, Antoñana, J.M., additional, and Sobradillo, V., additional

Published
1992
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48. Characteristics of a population of COPD patients identified from a population-based study. Focus on previous diagnosis and never smokers

Author

Miravitlles, M., Ferrer, M., Pont, A., Luis Viejo, J., Fernando Masa, J., Gabriel, R., Jimenez-Ruiz, C.A., Villasante, C., Fernandez-Fau, L., and Sobradillo, V.

Abstract

Objective: To identify factors associated with diagnosis and health-related quality of life (HRQL) impairment in chronic obstructive pulmonary disease (COPD) patients from a population-based epidemiological study. Design and participants: This was an epidemiologic, multicenter, population-based study. Three hundred and sixty-three individuals diagnosed with COPD from a randomly general population sample of 4035 individuals aged 40-69 were included in the analyses. Interventions: Forced spirometry was performed on eligible subjects, and the European Commission for Steel and Coal (ECSC) and the St. George's Respiratory Questionnaires (SGRQ) were completed. Logistic regression models were constructed to identify variables associated with the previous diagnosis of COPD and with COPD in never smokers. A multiple linear regression model attempted to identify variables influencing HRQL impairment. Results: Only 79 (21.7%) COPD patients had been previously diagnosed. Disease severity based on FEV"1, worse SGRQ score, previous respiratory disease, as well as the presence of wheezing were significantly associated with previous diagnosis. Being a woman, older than 55, with previous respiratory disease and without expectoration or wheezing characterized COPD in never smokers. A worse HRQL was associated with chronic symptoms, especially dyspnea; and with older age, cardiac comorbidity and impairment in lung function. Conclusions: Diagnosis of COPD in the community is more likely in patients with worse lung function and HRQL, and wheezing is the symptom most strongly associated with a diagnosis of COPD. Women older than 55, with previous respiratory diseases, without respiratory symptoms and mild airflow obstruction constitute the majority of individuals with COPD who have never smoked. Chronic respiratory symptoms are strongly associated with impairment in HRQL.

Published
2005
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