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7 results on '"Soboleski, Mark R."'

2. Vaccination to Conserved Influenza Antigens in Mice Using a Novel Simian Adenovirus Vector, PanAd3, Derived from the Bonobo Pan paniscus

Author

Vitelli, Alessandra, primary, Quirion, Mary R., additional, Lo, Chia-Yun, additional, Misplon, Julia A., additional, Grabowska, Agnieszka K., additional, Pierantoni, Angiolo, additional, Ammendola, Virginia, additional, Price, Graeme E., additional, Soboleski, Mark R., additional, Cortese, Riccardo, additional, Colloca, Stefano, additional, Nicosia, Alfredo, additional, and Epstein, Suzanne L., additional

Published
2013
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4. Single-Dose Mucosal Immunization with a Candidate Universal Influenza Vaccine Provides Rapid Protection from Virulent H5N1, H3N2 and H1N1 Viruses

Author

Price, Graeme E., primary, Soboleski, Mark R., additional, Lo, Chia-Yun, additional, Misplon, Julia A., additional, Quirion, Mary R., additional, Houser, Katherine V., additional, Pearce, Melissa B., additional, Pappas, Claudia, additional, Tumpey, Terrence M., additional, and Epstein, Suzanne L., additional

Published
2010
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6. Vaccination to Conserved Influenza Antigens in Mice Using a Novel Simian Adenovirus Vector, PanAd3, Derived from the Bonobo Pan paniscus.

Author

Vitelli, Alessandra, Quirion, Mary R., Lo, Chia-Yun, Misplon, Julia A., Grabowska, Agnieszka K., Pierantoni, Angiolo, Ammendola, Virginia, Price, Graeme E., Soboleski, Mark R., Cortese, Riccardo, Colloca, Stefano, Nicosia, Alfredo, and Epstein, Suzanne L.

Subjects
INFLUENZA vaccines, ANTIGENS, LABORATORY mice, ADENOVIRUSES, BONOBO, DISEASE vectors, TRANSGENES, NUCLEOPROTEINS, DISEASES
Abstract

Among approximately 1000 adenoviruses from chimpanzees and bonobos studied recently, the Pan Adenovirus type 3 (PanAd3, isolated from a bonobo, Pan paniscus) has one of the best profiles for a vaccine vector, combining potent transgene immunogenicity with minimal pre-existing immunity in the human population. In this study, we inserted into a replication defective PanAd3 a transgene expressing a fusion protein of conserved influenza antigens nucleoprotein (NP) and matrix 1 (M1). We then studied antibody and T cell responses as well as protection from challenge infection in a mouse model. A single intranasal administration of PanAd3-NPM1 vaccine induced strong antibody and T cell responses, and protected against high dose lethal influenza virus challenge. Thus PanAd3 is a promising candidate vector for vaccines, including universal influenza vaccines. [ABSTRACT FROM AUTHOR]

Published
2013
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7. Vaccination to Conserved Influenza Antigens in Mice Using a Novel Simian Adenovirus Vector, PanAd3, Derived from the Bonobo Pan paniscus.

Author

Vitelli, Alessandra, Quirion, Mary R., Lo, Chia-Yun, Misplon, Julia A., Grabowska, Agnieszka K., Pierantoni, Angiolo, Ammendola, Virginia, Price, Graeme E., Soboleski, Mark R., Cortese, Riccardo, Colloca, Stefano, Nicosia, Alfredo, and Epstein, Suzanne L.

Subjects
*INFLUENZA vaccines, *ANTIGENS, *LABORATORY mice, *ADENOVIRUSES, *BONOBO, *DISEASE vectors, *TRANSGENES, *NUCLEOPROTEINS, *DISEASES
Abstract

Among approximately 1000 adenoviruses from chimpanzees and bonobos studied recently, the Pan Adenovirus type 3 (PanAd3, isolated from a bonobo, Pan paniscus) has one of the best profiles for a vaccine vector, combining potent transgene immunogenicity with minimal pre-existing immunity in the human population. In this study, we inserted into a replication defective PanAd3 a transgene expressing a fusion protein of conserved influenza antigens nucleoprotein (NP) and matrix 1 (M1). We then studied antibody and T cell responses as well as protection from challenge infection in a mouse model. A single intranasal administration of PanAd3-NPM1 vaccine induced strong antibody and T cell responses, and protected against high dose lethal influenza virus challenge. Thus PanAd3 is a promising candidate vector for vaccines, including universal influenza vaccines. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

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