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14 results on '"Sobo, Matthew"'

12. MB-53hTERT EXPRESSION AND REGULATION IN PEDIATRIC MEDULLOBLASTOMA (MB)

Author

Salloum, Ralph, primary, author, co-first, additional, Sobo, Matthew, additional, Cobb, Patricia, additional, Hovestadt, Volker, additional, Ramaswamy, Vijay, additional, Remke, Marc, additional, Hoffman, Lindsey, additional, Dexheimer, Phillip, additional, Margol, Ashley, additional, Stevenson, Charles, additional, Asgharzadeh, Shahab, additional, Goldman, Stewart, additional, Miles, Lili, additional, Huang, Jie, additional, von Hoff, Katja, additional, Rutkowski, Stefan, additional, Onar-Thomas, Arzu, additional, Tabori, Uri, additional, Taylor, Michael, additional, Pfister, Stefan, additional, Fouladi, Maryam, additional, and Drissi, Rachid, additional

Published
2016
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13. A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas

Author

Hummel, Trent R., primary, Salloum, Ralph, additional, Drissi, Rachid, additional, Kumar, Shiva, additional, Sobo, Matthew, additional, Goldman, Stewart, additional, Pai, Ahna, additional, Leach, James, additional, Lane, Adam, additional, Pruitt, David, additional, Sutton, Mary, additional, Chow, Lionel M., additional, Grimme, Laurie, additional, Doughman, Renee, additional, Backus, Lori, additional, Miles, Lili, additional, Stevenson, Charles, additional, Fouladi, Maryam, additional, and DeWire, Mariko, additional

Published
2015
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14. Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas.

Author

Hutzen B, Friedman L, Sobo M, Lin L, Cen L, De Angelis S, Yamakoshi H, Shibata H, Iwabuchi Y, and Lin J

Subjects
Apoptosis drug effects, Breast Neoplasms genetics, Breast Neoplasms pathology, Cell Adhesion drug effects, Cell Line, Tumor, Cell Survival drug effects, Curcumin pharmacology, Dose-Response Relationship, Drug, Female, Humans, Inhibitory Concentration 50, Pancreatic Neoplasms genetics, Pancreatic Neoplasms pathology, Phosphorylation, STAT3 Transcription Factor genetics, STAT3 Transcription Factor metabolism, Transcription, Genetic drug effects, Transfection, Antineoplastic Agents, Phytogenic pharmacology, Breast Neoplasms metabolism, Cell Proliferation drug effects, Curcumin analogs & derivatives, Pancreatic Neoplasms metabolism, STAT3 Transcription Factor antagonists & inhibitors
Abstract

Curcumin has numerous anti-carcinogenic properties, but low bioavailability prevents its use in chemotherapeutic applications. One strategy for circumventing this problem has been the creation of synthetic analogues. We tested the efficacy of an analogue known as GO-Y030 in human breast and pancreatic cancer cells. We compared the impact of curcumin and GO-Y030 on the breast cancer cell line MDA-MB-231 and pancreatic cancer cell lines, PANC-1, HPAC and BXPC-3. Both compounds reduced cell viability and induced apoptosis, but GO-Y030 was substantially more potent. We also demonstrated that GO-Y030 was capable of interfering with STAT3, a persistently activated transcription factor in many cancer types. GO-Y030 inhibited STAT3 phosphorylation and transcriptional activity whereas comparable dosages of curcumin had little or no effect. These results indicate that GO-Y030 is a potent inhibitor of cell viability and STAT3 activation, and may thus have potential as a therapeutic agent for cancers expressing high levels of activated STAT3.

Published
2009
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