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1. A multivalent CD44 glycoconjugate vaccine candidate for cancer immunotherapy

Author

Freitas, Rui, Miranda, Andreia, Ferreira, Dylan, Relvas-Santos, Marta, Castro, Flávia, Ferreira, Eduardo, Gaiteiro, Cristiana, Soares, Janine, Cotton, Sofia, Gonçalves, Martina, Eiras, Mariana, Santos, Beatriz, Palmeira, Carlos, Correia, Margareta P., Oliveira, Maria José, Sarmento, Bruno, Peixoto, Andreia, Santos, Lúcio Lara, Silva, André M.N., and Ferreira, José Alexandre

Published
2024
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3. Stool Glycoproteomics Signatures of Pre-Cancerous Lesions and Colorectal Cancer

Author

Soares, Janine, primary, Eiras, Mariana, additional, Ferreira, Dylan, additional, Santos, Daniela A. R., additional, Relvas-Santos, Marta, additional, Santos, Beatriz, additional, Gonçalves, Martina, additional, Ferreira, Eduardo, additional, Vieira, Renata, additional, Afonso, Luís Pedro, additional, Santos, Lúcio Lara, additional, Dinis-Ribeiro, Mário, additional, Lima, Luís, additional, and Ferreira, José Alexandre, additional

Published
2024
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4. Aberrantly Glycosylated GLUT1 as a Poor Prognosis Marker in Aggressive Bladder Cancer

Author

Ferreira, Eduardo, primary, Ferreira, Dylan, additional, Relvas-Santos, Marta, additional, Freitas, Rui, additional, Soares, Janine, additional, Azevedo, Rita, additional, Afonso, Luís Pedro, additional, Lima, Luís, additional, Santos, Beatriz, additional, Gonçalves, Martina, additional, Silva, André M. N., additional, Santos, Lúcio Lara, additional, Peixoto, Andreia, additional, and Ferreira, José Alexandre, additional

Published
2024
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6. Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer

Author

Peixoto, Andreia, Ferreira, Dylan, Azevedo, Rita, Freitas, Rui, Fernandes, Elisabete, Relvas-Santos, Marta, Gaiteiro, Cristiana, Soares, Janine, Cotton, Sofia, Teixeira, Beatriz, Paulo, Paula, Lima, Luís, Palmeira, Carlos, Martins, Gabriela, Oliveira, Maria José, Silva, André M. N., Santos, Lúcio Lara, and Ferreira, José Alexandre

Published
2021
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7. Exploring sialyl-Tn expression in microfluidic-isolated circulating tumour cells: A novel biomarker and an analytical tool for precision oncology applications

Author

Neves, Manuel, Azevedo, Rita, Lima, Luís, Oliveira, Marta I., Peixoto, Andreia, Ferreira, Dylan, Soares, Janine, Fernandes, Elisabete, Gaiteiro, Cristiana, Palmeira, Carlos, Cotton, Sofia, Mereiter, Stefan, Campos, Diana, Afonso, Luís Pedro, Ribeiro, Ricardo, Fraga, Avelino, Tavares, Ana, Mansinho, Hélder, Monteiro, Eurico, Videira, Paula A., Freitas, Paulo P., Reis, Celso A., Santos, Lúcio Lara, Dieguez, Lorena, and Ferreira, José Alexandre

Published
2019
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9. Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion

Author

Gaiteiro, Cristiana, primary, Soares, Janine, additional, Relvas-Santos, Marta, additional, Peixoto, Andreia, additional, Ferreira, Dylan, additional, Paulo, Paula, additional, Brandão, Andreia, additional, Fernandes, Elisabete, additional, Azevedo, Rita, additional, Palmeira, Carlos, additional, Freitas, Rui, additional, Miranda, Andreia, additional, Osório, Hugo, additional, Prieto, Jesús, additional, Lima, Luís, additional, Silva, André M. N., additional, Santos, Lúcio Lara, additional, and Ferreira, José Alexandre, additional

Published
2022
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10. Glycoproteogenomics characterizes the CD44 splicing code driving bladder cancer invasion

Author

Gaiteiro, Cristiana, primary, Soares, Janine, additional, Relvas-Santos, Marta, additional, Peixoto, Andreia, additional, Ferreira, Dylan, additional, Brandão, Andreia, additional, Fernandes, Elisabete, additional, Azevedo, Rita, additional, Paulo, Paula, additional, Palmeira, Carlos, additional, Lima, Luís, additional, Freitas, Rui, additional, Miranda, Andreia, additional, Osório, Hugo, additional, Silva, André M. N., additional, Prieto, Jesús, additional, Lara Santos, Lúcio, additional, and Ferreira, José Alexandre, additional

Published
2021
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11. O velamento das fundações privadas pelo Ministério Público = The supervision of activities of charitable foundations by the Public Prosecutors’ Office in Brazil

Author

Soares, Janine Borges and Clos, Keller Dornelles

Abstract

Submitted by phemiran@stj.jus.br (phemiran@stj.jus.br) on 2021-12-08T16:03:49Z No. of bitstreams: 2 velamento_fundacoes_privadas_soares.pdf: 1122143 bytes, checksum: 9308134ef591da73971320ac63c06fda (MD5) license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) Approved for entry into archive by betanial@stj.jus.br (betanial@stj.jus.br) on 2021-12-08T19:41:56Z (GMT) No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) velamento_fundacoes_privadas_soares.pdf: 1122143 bytes, checksum: 9308134ef591da73971320ac63c06fda (MD5) Made available in DSpace on 2021-12-08T19:41:56Z (GMT). No. of bitstreams: 2 license.txt: 1239 bytes, checksum: c9b4c351324448672315a00808efb725 (MD5) velamento_fundacoes_privadas_soares.pdf: 1122143 bytes, checksum: 9308134ef591da73971320ac63c06fda (MD5) Previous issue date: 2021

Published
2021

12. Additional file 2 of Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer

Author

Peixoto, Andreia, Ferreira, Dylan, Azevedo, Rita, Freitas, Rui, Fernandes, Elisabete, Relvas-Santos, Marta, Gaiteiro, Cristiana, Soares, Janine, Cotton, Sofia, Teixeira, Beatriz, Paulo, Paula, Lima, Luís, Palmeira, Carlos, Martins, Gabriela, Oliveira, Maria José, Silva, André M. N., Santos, Lúcio Lara, and Ferreira, José Alexandre

Subjects
Data_FILES
Abstract

Additional file 2.

Published
2021
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13. Metabolomics, Transcriptomics and Functional Glycomics Reveals Bladder Cancer Cells Plasticity and Enhanced Aggressiveness Facing Hypoxia and Glucose Deprivation

Author

Peixoto, Andreia, primary, Freitas, Rui, additional, Ferreira, Dylan, additional, Relvas-Santos, Marta, additional, Paulo, Paula, additional, Cardoso, Marta, additional, Soares, Janine, additional, Gaiteiro, Cristiana, additional, Palmeira, Carlos, additional, Teixeira, Filipe, additional, Ferreira, Rita, additional, José Oliveira, Maria, additional, Silva, André M. N., additional, Lara Santos, Lúcio, additional, and Ferreira, José Alexandre, additional

Published
2021
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14. Target Score—A Proteomics Data Selection Tool Applied to Esophageal Cancer Identifies GLUT1-Sialyl Tn Glycoforms as Biomarkers of Cancer Aggressiveness

Author

Cotton, Sofia, primary, Ferreira, Dylan, additional, Soares, Janine, additional, Peixoto, Andreia, additional, Relvas-Santos, Marta, additional, Azevedo, Rita, additional, Piairo, Paulina, additional, Diéguez, Lorena, additional, Palmeira, Carlos, additional, Lima, Luís, additional, Silva, André M. N., additional, Lara Santos, Lúcio, additional, and Ferreira, José Alexandre, additional

Published
2021
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17. Nucleolin-Sle A Glycoforms as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells

Author

Fernandes, Elisabete, primary, Freitas, Rui, additional, Ferreira, Dylan, additional, Soares, Janine, additional, Azevedo, Rita, additional, Gaiteiro, Cristiana, additional, Peixoto, Andreia, additional, Oliveira, Sara, additional, Cotton, Sofia, additional, Relvas-Santos, Marta, additional, Afonso, Luis Pedro, additional, Palmeira, Carlos, additional, Oliveira, Maria José, additional, Ferreira, Rita, additional, Silva, André M. N., additional, Lara Santos, Lúcio, additional, and Ferreira, José Alexandre, additional

Published
2020
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18. PROGRAMA SAÚDE E CIDADANIA

Author

BLANCO, Soeli Francisca Mazzini Monte, D’ÁVILA, Carolina, SOARES, Janine, OLIVEIRA, Lara Louize Pereira de, and SILVA, Nathalya Maris da

Subjects
saúde na escola, cultura de paz, direitos humanos
Abstract

O Programa de Extensão “Saúde e Cidadania”, está vinculado ao Centro de Educação a Distância (CEAD) da UDESC e aos laboratórios de Educação Sexual (LabEduSex) e Laboratório de Direitos Humanos (LabDH), e parceria com o Núcleo de Estudos Afro- Brasileiros (NEAB/UDESC). Com o objetivo de contribuir para o conhecimento e aplicação de ações pedagógicas relacionadas à educação sexual, educação inclusiva, educação para as relações étnico-raciais e cultura de paz, auxiliando na construção de uma sociedade que respeita os direitos humanos e os direitos da criança e do adolescente. O programa será composto por quatro ações: oficinas para os estudantes e professores das escolas parceiras selecionadas, em Florianópolis (SC) e em Santa Maria (RS), e também dois cursos de extensão online, que são eles “Curso de Libras: Conhecer a cultura surda” e “Educação e Direitos Humanos: por uma educação antirracista” e por fim a produção de materiais para formação de um repositório. A avaliação acontecerá durante todo o processo pela equipe executora e ao final dos cursos pelos cursistas (avaliação da organização e conteúdo). Na avaliação procurar-se-á verificar se os organizadores e participantes alcançaram os objetivos propostos e se o trabalho desenvolvido proporcionou ao grupo a reavaliação de conceitos e desenvolvimento pessoal. Na conclusão entendemos que a indissociabilidade entre extensão, ensino e pesquisa na UDESC, é fundamental para a articulação entre a teoria e a prática, possibilitando o intercâmbio de saberes entre academia e sociedade. Compreendemos que o trabalho curricular e interdisciplinar tem por função produzir e socializar o conhecimento pela inserção na realidade, possibilitando ao discente bolsista uma vivência que complemente sua formação profissional e cidadã, articulando tempo acadêmico com experiência de vida.

Published
2019

20. Sialyl-Tn identifies muscle-invasive bladder cancer basal and luminal subtypes facing decreased survival, being expressed by circulating tumor cells and metastases

Author

Lima, Luís, primary, Neves, Manuel, additional, Oliveira, Marta I., additional, Dieguez, Lorena, additional, Freitas, Rui, additional, Azevedo, Rita, additional, Gaiteiro, Cristiana, additional, Soares, Janine, additional, Ferreira, Dylan, additional, Peixoto, Andreia, additional, Fernandes, Elisabete, additional, Montezuma, Diana, additional, Tavares, Ana, additional, Ribeiro, Ricardo, additional, Castro, Ana, additional, Oliveira, Manuel, additional, Fraga, Avelino, additional, Reis, Celso A., additional, Santos, Lúcio Lara, additional, and Ferreira, José Alexandre, additional

Published
2017
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22. Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes proteinO-glycosylation extension

Author

Peixoto, Andreia, primary, Fernandes, Elisabete, additional, Gaiteiro, Cristiana, additional, Lima, Luís, additional, Azevedo, Rita, additional, Soares, Janine, additional, Cotton, Sofia, additional, Parreira, Beatriz, additional, Neves, Manuel, additional, Amaro, Teresina, additional, Tavares, Ana, additional, Teixeira, Filipe, additional, Palmeira, Carlos, additional, Rangel, Maria, additional, Silva, André M.N., additional, Reis, Celso A., additional, Santos, Lúcio Lara, additional, Oliveira, Maria José, additional, and Ferreira, José Alexandre, additional

Published
2016
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23. Glycan affinity magnetic nanoplatforms for urinary glycobiomarkers discovery in bladder cancer.

Author

Soares, Janine, Ferreira, Dylan, Relvas-Santos, Marta, Tavares, Ana, Cotton, Sofia, Azevedo, Rita, Gaiteiro, Cristiana, Santos, Lúcio Lara, Peixoto, Andreia, Fernandes, Elisabete, Ferreira, José Alexandre, Lima, Luís, Daniel-da-Silva, Ana Luísa, Vitorino, Rui, and Amado, Francisco

Subjects
*GLYCAN analysis, *MAGNETIC nanoparticles, *BLADDER cancer diagnosis, *BIOLOGICAL tags, *URINALYSIS, *GLYCOSYLATION
Abstract

Bladder Cancer (BC) presents one of the highest recurrence rates amongst solid tumours and constitutes the second deadliest disease of the genitourinary track. Non-invasive identification of patients facing disease recurrence and/or progression remains one of the most critical and challenging aspects in disease management. To contribute to this goal, we demonstrate the potential of glycan-affinity glycoproteomics nanoplatforms for urinary biomarkers discovery in bladder cancer. Briefly, magnetic nanoprobes (MNP) coated with three broad-spectrum lectins, namely Concanavalin A (ConA; MNP@ConA), Wheat Germ Agglutinin (WGA; MNP@WGA), and Sambucus nigra (SNA; MNP@SNA), were used to selectively capture glycoproteins from the urine of low-grade and high-grade non-muscle invasive as well as muscle-invasive BC patients. Proteins were identified by nano-LC MALDI-TOF/TOF and data was curated using bioinformatics tools (UniProt, NetOGlyc, NetNGlyc, ClueGO app for Cytoscape and Oncomine) to highlight clinically relevant species. Accordingly, 63 glycoproteins were exclusively identified in cancer samples compared with healthy controls matching in age and gender. Specific glycoprotein sets exclusively found in low-grade non-muscle invasive bladder tumours may aid early diagnosis, while those only found in high-grade non-invasive and muscle-invasive tumours hold potential for accessing progression. Amongst these proteins is bladder cancer stem-cell marker CD44, which has been associated with poor prognosis. Orthogonal validation studies by slot-blotting demonstrated an elevation in urine CD44 levels of high-grade patients, which became more pronounced upon muscle-invasion, in mimicry of the primary tumour. These observations demonstrate the potential of MNP@lectins for identification of clinically relevant glycoproteomics signatures in bladder cancer. Future clinical validation in a larger and well characterized patient subset is required envisaging clinical translation of the results. [ABSTRACT FROM AUTHOR]

Published
2018
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24. Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension.

Author

Peixoto A, Fernandes E, Gaiteiro C, Lima L, Azevedo R, Soares J, Cotton S, Parreira B, Neves M, Amaro T, Tavares A, Teixeira F, Palmeira C, Rangel M, Silva AM, Reis CA, Santos LL, Oliveira MJ, and Ferreira JA

Subjects
Adult, Aged, Aged, 80 and over, Antigens, CD metabolism, Antigens, Neoplasm metabolism, Carbonic Anhydrase IX metabolism, Cell Hypoxia, Cell Line, Tumor, Cell Movement, Deferoxamine chemistry, Female, Glycoproteins metabolism, Humans, Hypoxia-Inducible Factor 1, alpha Subunit metabolism, Lactic Acid chemistry, Male, Middle Aged, Neoplasm Invasiveness, Phenotype, Polysaccharides chemistry, Proteomics, Sialyltransferases metabolism, Urinary Bladder Neoplasms metabolism, Glycosylation, Urinary Bladder Neoplasms pathology
Abstract

Invasive bladder tumours express the cell-surface Sialyl-Tn (STn) antigen, which stems from a premature stop in protein O-glycosylation. The STn antigen favours invasion, immune escape, and possibly chemotherapy resistance, making it attractive for target therapeutics. However, the events leading to such deregulation in protein glycosylation are mostly unknown. Since hypoxia is a salient feature of advanced stage tumours, we searched into how it influences bladder cancer cells glycophenotype, with emphasis on STn expression. Therefore, three bladder cancer cell lines with distinct genetic and molecular backgrounds (T24, 5637 and HT1376) were submitted to hypoxia. To disclose HIF-1α-mediated events, experiments were also conducted in the presence of Deferoxamine Mesilate (Dfx), an inhibitor of HIF-1α proteasomal degradation. In both conditions all cell lines overexpressed HIF-1α and its transcriptionally-regulated protein CA-IX. This was accompanied by increased lactate biosynthesis, denoting a shift toward anaerobic metabolism. Concomitantly, T24 and 5637 cells acquired a more motile phenotype, consistent with their more mesenchymal characteristics. Moreover, hypoxia promoted STn antigen overexpression in all cell lines and enhanced the migration and invasion of those presenting more mesenchymal characteristics, in an HIF-1α-dependent manner. These effects were reversed by reoxygenation, demonstrating that oxygen affects O-glycan extension. Glycoproteomics studies highlighted that STn was mainly present in integrins and cadherins, suggesting a possible role for this glycan in adhesion, cell motility and invasion. The association between HIF-1α and STn overexpressions and tumour invasion was further confirmed in bladder cancer patient samples. In conclusion, STn overexpression may, in part, result from a HIF-1α mediated cell-survival strategy to adapt to the hypoxic challenge, favouring cell invasion. In addition, targeting STn-expressing glycoproteins may offer potential to treat tumour hypoxic niches harbouring more malignant cells.

Published
2016
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