2,854 results on '"So Min Oh"'
Search Results
2. Permeability monitoring of underground concrete structures using elastic wave characteristics with modified Biot’s model
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Jong-Won Lee, Jin-Seop Kim, Chang-Ho Hong, and Tae-Min Oh
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Permeability ,Concrete ,Elastic wave ,P-wave velocity ,Attenuation ,Biot’s model ,Medicine ,Science - Abstract
Abstract This study aims to develop a theoretical model for predicting the permeability of concrete in underground structures using compressive elastic waves. This research is motivated by the necessity of monitoring the permeability of concrete used in critical underground infrastructure, such as tunnels and radioactive waste disposal sites, to ensure their long-term safety. Increased permeability owing to crack generation can lead to groundwater inflow, undermining the structural integrity of these facilities. Traditional methods for permeability monitoring face challenges at depths of 500 m–1 km owing to high temperatures, high pressures, and limited space conditions. To address these issues, Biot’s model, which correlates the P-wave characteristics with the properties of porous media, was applied in this study. The P-wave velocity and attenuation were studied according to the permeability of concrete based on Biot’s model. Subsequently, concrete specimens were prepared to measure the permeability, P-wave velocity, and attenuation. The permeability results from the experiment were compared with those obtained from the model for validation. The findings indicate that the modified Biot’s model can effectively monitor permeability through elastic wave characteristics, offering a non-destructive and reliable method for assessing the condition of concrete structures in underground environments. This approach is expected to enhance the safety of underground infrastructure through accurate permeability monitoring.
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- 2024
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3. Inhibitory effect of human indoleamine 2,3-dioxygenase 1 (hIDO1) by kazinols of 1,3-diphenylpropane derivatives
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Taehoon Oh, Sunin Jung, Seon Min Oh, Mi Hyeon Park, Hyoung-Geun Kim, Su-Yeon Lee, Sung-Kyun Ko, and Hyung Won Ryu
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Kazinol ,1,3-diphenylpropane ,Affinity-based ultrafiltration ,Human indoleamine 2,3-dioxygenase 1 ,Docking simulations ,Agriculture (General) ,S1-972 ,Chemistry ,QD1-999 - Abstract
Abstract This study focused on identifying and characterizing 1,3-diphenylpropane derivatives from flavonoids that inhibit human indoleamine 2,3-dioxygenase 1 (hIDO1) enzymes, which play a role in immune regulation and are associated with various diseases. A series of isolated metabolites (1–7) demonstrated modest to high inhibition of hIDO1, with binding degree values ranging from 26.31 to 72.17%. In particular, during a target-based screening of natural products using hIDO1, kazinol J (6, a 1,3-diphenylpropane derivative) was found to potently inhibit hIDO1, with a binding degree of 72.17% at 1 ppm. Kazinol J (6) showed concentration-dependent and mixed inhibition kinetics and achieved slow and time-dependent inhibition of hIDO1. Additionally, docking simulations were performed to evaluate the inhibitory potential and binding interactions of the compounds with hIDO1. These findings suggest that these 1,3-diphenylpropane derivatives can serve as therapeutic agents for conditions involving hIDO1 dysregulation, such as cancer, autoimmune disorders, and infectious diseases.
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- 2024
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4. Metabolomics study to reveal cognitive improvement with treatment of Scrophularia buergeriana
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Dahye Yoon, Seon Min Oh, Hyeon Seon Na, Bo-Ram Choi, Kwan-Woo Kim, Young-Seob Lee, Dong-Ryung Lee, and Dae Young Lee
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Medicine ,Science - Abstract
Abstract Population aging around the world is rapidly progressing; as a result, cognitive decline developing into dementia is becoming a social problem. There is no drug that can cure dementia, and though drugs that alleviate the symptoms of dementia have been developed, they also have side effects. Therefore, we conducted a study on improving cognitive function using natural products that have secured safety. We confirmed the effect of an extract of Scrophularia buergeriana on scopolamine-induced cognitive impairment through mouse behavioral experiments, and we observed metabolic changes in the cortex and hippocampus via brain tissue dissection after the behavioral experiment. Mitigating effects of S. buergeriana on cognitive impairment caused by scopolamine were observed in passive avoidance and Morris water maze tests. A metabolic analysis revealed biomarkers related to the alleviating effect of cognitive impairment. Niacinamide, tyrosine, uridine, and valine in the cortex and GABA, choline, creatine, formate, fumarate, hypoxanthine, leucine, myo-inositol, pyroglutamate, and taurine in the hippocampus were identified as biomarker candidates for recovering cognitive impairment. In addition to behavioral experiments, this metabolomics study using specific regions of the brain may be helpful in understanding the effects of cognitive improvement.
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- 2024
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5. Synthesis, biochemistry, and in silico investigations of isatin-based hydrazone derivatives as monoamine oxidase inhibitors
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Naseer Maliyakkal, Jong Min Oh, Sunil Kumar, Prashant Gahori, Anandkumar Tengli, Asmy Appadath Beeran, Hoon Kim, and Bijo Mathew
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Isatin ,Hydrazone ,Monoamine oxidase inhibition ,Reversibility ,Kinetics ,Molecular dynamics ,Agriculture (General) ,S1-972 ,Chemistry ,QD1-999 - Abstract
Abstract Ten isatin-based hydrazone derivatives were synthesized using two subseries, IA (isatin + acetophenone) and IB (isatin + benzaldehyde), and evaluated for their monoamine oxidases (MAOs) inhibitory activity. All the compounds showed stronger MAO-A inhibition than MAO-B, and the IB series showed more effective MAO-A inhibitory activity than IA series. Compound IB4 most potently inhibited MAO-A (half maximal inhibitory concentration IC50 = 0.015 µM), followed by IB3 (IC50 = 0.019 µM). On the contrary, compound IB3 showed the highest MAO-B inhibition (IC50 = 0.068 µM), followed by IB4 (IC50 = 1.87 µM). Compound IB3 and IB4 had low selectivity indices of 3.68 and 8.50, respectively. Structurally, the methyl group of IA series decreased the inhibition of both MAO-A and MAO-B. Among them, IB3 and IB4 (4-Cl and 4-Br in B-ring, respectively) showed higher MAO-A and MAO-B inhibition than the other substitutions. Inhibition constant Ki values of IB3 and IB4 for MAO-A were 0.0088 and 0.0063 µM, respectively, and those for MAO-B were 0.048 and 0.060 µM, respectively. IB3 and IB4 were competitive, reversible inhibitors of MAO-A and MAO-B. Molecular docking analysis predicted that IB3 and IB4 formed stable hydrogen bonds between Asn181 and the NH atom of isatin in the ligand-protein complex. Dynamic analysis revealed that IB3 and IB4 are stable with both MAO isoforms. These observations suggest IB3 and IB4 are potent and reversible MAO-A and MAO-B inhibitors and both compounds can be used as therapeutic agents for neurological disorders.
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- 2024
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6. Multifunctional MXene/Carbon Nanotube Janus Film for Electromagnetic Shielding and Infrared Shielding/Detection in Harsh Environments
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Tufail Hassan, Aamir Iqbal, Byungkwon Yoo, Jun Young Jo, Nilufer Cakmakci, Shabbir Madad Naqvi, Hyerim Kim, Sungmin Jung, Noushad Hussain, Ujala Zafar, Soo Yeong Cho, Seunghwan Jeong, Jaewoo Kim, Jung Min Oh, Sangwoon Park, Youngjin Jeong, and Chong Min Koo
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MXene/carbon nanotube Janus film ,Electromagnetic interference shielding ,Infrared shielding ,Thermal camouflage ,Infrared detection ,Technology - Abstract
Highlights A multifunctional Janus film is fabricated by integrating highly-crystalline and oxidation-resistant Ti3C2T x MXene with carbon nanotube (CNT) film through strong hydrogen bonding, which exhibits high electrical conductivity of 4250 S cm−1 and robust mechanical strength of 77 MPa. The MXene/CNT Janus film of 15 μm thickness demonstrates efficient electromagnetic interference shielding of 72 dB, low infrared (IR) emissivity of 0.09 and hence superior thermal camouflage performance, and outstanding IR detection capability, while maintaining its integrity equally at room temperature as well as under extreme conditions. This multifunctional MXene/CNT Janus film offers a practical solution for electromagnetic shielding and IR shielding/detection in challenging conditions.
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- 2024
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7. Regional comparison study of Epimedium koreanum using UHPLC-QTOF/MS-based metabolomics approach
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Alfan Danny Arbianto, Min Kim, Seon Min Oh, Hyun-Jae Jang, Hyung Won Ryu, Jin-Hyub Paik, Sei-Ryang Oh, and Jongmin Ahn
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Epimedium koreanum ,Metabolomics ,Molecular networking ,Multivariate analysis ,Agriculture (General) ,S1-972 ,Chemistry ,QD1-999 - Abstract
Abstract The untargeted metabolomics-based molecular networking approach combined with multivariate analysis, proves to be an effective strategy for distinguishing raw materials in herbal medicine according to specific criteria. It exhibits the correlations between chemical constituents and the geographical habitats of plants, providing a valuable tool for ensuring quality control in mass production within the industry. In this study, we conducted a comprehensive investigation of the chemical compositions of Epimedium koreanum Nakai and performed comparative analyses on four extracts collected from distinct regions in South Korea using untargeted metabolomics tools. Through the comprehensive use of UPLC-QTOF/MS analysis and advanced statistical techniques, we elucidated the chemical composition, leading to the identification of key chemical markers. Additionally, the molecular networking analysis revealed distinct clusters of flavonoids and phenolic acids, highlighting the influence of regional factors on the metabolite profiles. These findings offer a promising avenue for enhancing quality control and traceability in the herbal medicine industry, underscoring the important role of geographical variation in the chemical profiles of herbal products.
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- 2024
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8. Sports-related fractures in the geriatric population at a level I trauma center
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Young Dae Jeon, Ki-Bong Park, Sang-Hun Ko, Jae-Min Oh, and Sang-Gon Kim
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General sports trauma ,Geriatric ,Fracture ,Epidemiology ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background The population is rapidly aging and remains active over the age of 65 years. An increasing number of sports-related fractures (SRFs) in individuals 65 and older are thus anticipated. Despite the increase in SRFs among the geriatric population, there are limited studies regarding the epidemiological data regarding SRFs in geriatric patients. This study examined the epidemiology of SRFs in a geriatric population who visited a level I trauma center. Methods Data from geriatric patients who visited a level I trauma center were collected between June 2020 and July 2023. Overall, 1,109 geriatric patients with fractures were included in the study. Among them, 144 (13.0%) had fractures during sports activities (SRF group) and 965 (87.0%) had fractures during non-sports activities (non-SRF group). We investigated the type of sport in the SRFs and compared SRFs and NSRFs to describe the differences in patient, fracture, and treatment characteristics. Results The mean age of SRFs was significantly lower (73.6 vs. 78.7 years; P
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- 2024
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9. Seed traits inheritance in Fagopyrum esculentum Moench. based on image analysis method
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Min Ah Oh, Ji Eun Park, Jae Young Kim, Ho-Min Kang, San Su Min Oh, Sheikh Mansoor, and Yong Suk Chung
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RGB imaging ,plant breeding ,phenotyping ,image analysis ,common buckwheat ,Plant culture ,SB1-1110 - Abstract
Common buckwheat (Fagopyrum esculentum Moench.) is one of the most important orphan crops worldwide. Various research efforts have been done to improve cultivation methods to enhance important agronomic traits such as productivity and biotic/abiotic resistance. One important aspect is the seed trait, which has not been extensively studied due to the time-consuming and tedious nature of its examination. Despite this, understanding seed traits is crucial for meeting consumer needs and optimizing crop yields. Therefore, the aim of the study is to investigate the inheritance of common buckwheat seed traits—such as shape, size, and coat color—using an image-based approach. This method allows for the analysis of a large number of seeds with a level of accuracy and precision that was previously unattainable. The results indicate that seed coat color is inherited maternally. Notably, the parameters in size had substantial increases acting like overdominance. The number of seeds that were harvested from F1s of each cross differed a lot depending on the cross combinations and pin/thrum type. In addition, seed size had large reduction in F1s from the different seed-sized parents, especially in thrum type. These may show that there could be cross barriers. The results revealed trends of maternal inheritance for seed shape and coat color in buckwheat, an area that has not been extensively studied. These findings could support buckwheat breeding efforts, helping to address market needs and food demands in the face of significant climate change.
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- 2024
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10. Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells
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Yongmin Cho, Moon Nyeo Park, Min Choi, Tarun Kumar Upadhyay, Han Na Kang, Jeong Min Oh, Soonki Min, Ji-Ung Yang, Moonkyoo Kong, Seong-Gyu Ko, Md Ataur Rahman, Abdel Halim Harrath, and Bonglee Kim
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pancreatic cancer ,sulforaphane (SFN) ,reactive oxygen species (ROS) ,mitochondrial membrane potential (ΔΨm) ,sub G1 ,γH2A.X ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundPancreatic cancer (PC), sometimes referred to as pancreatic ductal adenocarcinoma (PDAC), is a major cause of global mortality from cancer. Pancreatic cancer is a very aggressive and devastating kind of cancer, characterized by limited options for therapy and low possibilities of survival. Sulforaphane (SFN), a naturally occurring sulfur-containing compound, is believed to possess anti-inflammatory, anti-obesity, and anti-cancer characteristics.ObjectiveHowever, efficient preventative and treatment measures are essential and SFN has been studied for its ability to suppress pancreatic cancer cell proliferation and induce apoptosis.MethodsHere, SFN induced cytotoxicity and apoptosis in PDAC cell lines such as MIA PaCa-2 and PANC-1 cells, as evaluated by cytotoxicity, colony formation, western blot analysis, fluorescence-activated cell sorting (FACS), reactive oxygen species (ROS) detection, caspase-3 activity assay, immunofluorescence assay, and mitochondrial membrane potential assay.ResultsIn MIA PaCa-2 and PANC-1 cells, SFN inhibited cell survival and proliferation in a dose-dependent manner. The activation of caspase zymogens results in cleaved PARP and cleaved caspase-3, which is associated with an accumulation in the sub G1 phase. Furthermore, SFN increased ROS level and γH2A.X expression while decreasing mitochondrial membrane potential (ΔΨm). Notably, the ROS scavenger N-Acetyl-L-cysteine (NAC) was shown to reverse SFN-induced cytotoxicity and ROS level. Subsequently, SFN-induced cell cycle arrest and apoptosis induction as a Trojan horse to eliminate pancreatic cancer cells via ROS-mediated pathways were used to inhibit pancreatic cancer cells.ConclusionCollectively, our data demonstrates that SFN-induced cell death follows the apoptosis pathway, making it a viable target for therapeutic interventions against pancreatic cancer.
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- 2024
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11. Comparison of blood loss between intra-articular microporous polysaccharide hemospheres powder and tranexamic acid following primary total knee arthroplasty
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Young-Dae Jeon, Jae-Ryong Cha, Jae-Min Oh, Sang-Gon Kim, and Ki-Bong Park
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Knee ,Total knee arthroplasty ,Blood loss ,Hemostatic ,Microporous polysaccharide hemospheres ,Tranexamic acid ,Medicine ,Science - Abstract
Abstract Total knee arthroplasty (TKA) is associated with substantial blood loss and tranexamic acid (TXA) effectively reduces postoperative bleeding. Although it is known that there is no difference between intravenous or intra-articular (IA) injection, the general interest is directed towards topical hemostatic agents regarding thromboembolic events in high-risk patients. This study aimed to compare the blood conservation effects of IA MPH powder and TXA in patients undergoing primary TKA. We retrospectively analyzed 103 patients who underwent primary TKA between June 2020 and December 2021. MPH powder was applied to the IA space before capsule closure (MPH group, n = 51). TXA (3 g) was injected via the drain after wound closure (TXA group, n = 52). All patients underwent drain clamping for three postoperative hours. The primary outcome was the drain output, and the secondary outcomes were the postoperative hemoglobin (Hb) levels during the hospitalization period and the perioperative blood transfusion rates. An independent Student’s t-test was used to determine differences between the two groups. The drain output in the first 24 h after surgery was significantly higher in the MPH group than in the TXA group. The postoperative Hb levels were significantly lower in the MPH group than in the TXA group. In patients with simultaneous bilateral TKA, there was a significant difference in the blood transfusion volumes and the rates between groups. It is considered that IA MPH powder cannot replace IA TXA because of an inferior efficacy in reducing blood loss and maintaining postoperative Hb levels in the early postoperative period after primary TKA. Moreover, in the case of simultaneous bilateral TKA, we do not recommend the use of IA MPH powder because it was notably less effective in the field of transfusion volume and rate.
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- 2024
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12. Pannorin isolated from marine Penicillium sp. SG-W3: a selective monoamine oxidase A inhibitor
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Jong Min Oh, Qian Gao, Woong-Hee Shin, Eun-Young Lee, Dawoon Chung, Grace Choi, Sang-Jip Nam, and Hoon Kim
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Penicillium sp. SG-W3 ,Pannorin ,Monoamine oxidase ,Enzyme kinetics ,Reversible competitive inhibitor ,Molecular docking and dynamics ,Agriculture (General) ,S1-972 ,Chemistry ,QD1-999 - Abstract
Abstract Six compounds were isolated from Penicillium sp. SG-W3, a marine-derived fungus, and their inhibitory activities against target enzymes relating to neurological diseases were evaluated. Compound 1 (pannorin) was a potent and selective monoamine oxidase (MAO)-A inhibitor with a 50% inhibitory concentration (IC50) of 1.734 μM and a selectivity index (SI) of > 23.07 versus MAO-B, and it showed an efficient antioxidant activity. All compounds showed weak inhibitory activities against acetylcholinesterase, butyrylcholinesterase, and β-secretase. The inhibition constant (Ki) of 1 for MAO-A was 1.049 ± 0.030 μM with competitive inhibition. Molecular docking simulation predicted that compound 1 forms hydrogen bonds with MAO-A, and binds more tightly to MAO-A than to MAO-B (− 25.02 and − 24.06 kcal/mol, respectively). These results suggest that compound 1 is a selective, reversible, and competitive MAO-A inhibitor that can be a therapeutic candidate for treating neurological diseases.
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- 2024
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13. Importance of dietary supplementation of soluble and insoluble fibers to sows subjected to high ambient temperatures during late gestation and effects on lactation performance
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Seung Min Oh, Abdolreza Hosseindoust, Sang Hun Ha, Jun Young Mun, Joseph Moturi, Habeeb Tajudeen, Yo Han Choi, Su Hyup Lee, and Jin Soo Kim
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Soluble fiber ,Insoluble fiber ,Beet pulp ,Wheat bran ,Palm kernel ,Metabolites ,Animal culture ,SF1-1100 - Abstract
Heat stress adversely affects sows' performance, which can be improved by applying proper nutritional strategies. This study was conducted to investigate the interactive effects of dietary fiber levels and sources on sows' reproductive performance, metabolic response during gestation, and the carry-over influence on litter performance in the lactation period during heat stress (average room temperature of 27.1 °C). Fifty-four multiparous sows (Landrace × Yorkshire; initial body weight of 236.3 ± 16 kg; 2, 3 and 4 parities) at d 90 of gestation were assigned to a 2 × 3 factorial arrangement (9 sows/treatment), involving 2 dietary fiber levels (4.5% and 6% crude fiber) and 3 dietary fiber sources (wheat bran [WB], palm kernel meal [PK], and beet pulp [BP]). Sows fed the BP diet had highest (P
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- 2024
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14. Machine learning driven web-based app platform for the discovery of monoamine oxidase B inhibitors
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Sunil Kumar, Ratul Bhowmik, Jong Min Oh, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rasha Hamed Al‑Serwi, Hoon Kim, and Bijo Mathew
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Monoamine oxidase B ,ML-QSAR ,PubChem fingerprints ,Substructure fingerprints ,1D and 2D molecular descriptors ,Prediction models ,Medicine ,Science - Abstract
Abstract Monoamine oxidases (MAOs), specifically MAO-A and MAO-B, play important roles in the breakdown of monoamine neurotransmitters. Therefore, MAO inhibitors are crucial for treating various neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS). In this study, we developed a novel cheminformatics pipeline by generating three diverse molecular feature-based machine learning-assisted quantitative structural activity relationship (ML-QSAR) models concerning MAO-B inhibition. PubChem fingerprints, substructure fingerprints, and one-dimensional (1D) and two-dimensional (2D) molecular descriptors were implemented to unravel the structural insights responsible for decoding the origin of MAO-B inhibition in 249 non-reductant molecules. Based on a random forest ML algorithm, the final PubChem fingerprint, substructure fingerprint, and 1D and 2D molecular descriptor prediction models demonstrated significant robustness, with correlation coefficients of 0.9863, 0.9796, and 0.9852, respectively. The significant features of each predictive model responsible for MAO-B inhibition were extracted using a comprehensive variance importance plot (VIP) and correlation matrix analysis. The final predictive models were further developed as a web application, MAO-B-pred ( https://mao-b-pred.streamlit.app/ ), to allow users to predict the bioactivity of molecules against MAO-B. Molecular docking and dynamics studies were conducted to gain insight into the atomic-level molecular interactions between the ligand-receptor complexes. These findings were compared with the structural features obtained from the ML-QSAR models, which supported the mechanistic understanding of the binding phenomena. The presented models have the potential to serve as tools for identifying crucial molecular characteristics for the rational design of MAO-B target inhibitors, which may be used to develop effective drugs for neurodegenerative disorders.
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- 2024
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15. Nano-Sized rGO-Encapsulated TiO2 Nanowire-Filled PDMS cone type dielectric elastomer actuator operating at low applied electric field
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Sung Seo, Jin, Tae Park, Kyoung, Min Oh, Su, In Kang, Hye, Kim, KiJong, Baeck, Sung-Hyeon, Eun Shim, Sang, and Qian, Yingjie
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- 2024
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16. Bioluminescence-induced photocatalysis on semiconducting oxide nanosheets
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Kai Kamada, Hideaki Sano, Osamu Nakagoe, Shuji Tanabe, and Jae-Min Oh
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Photocatalyst ,bioluminescence ,oxide nanosheet ,enzyme ,Clay industries. Ceramics. Glass ,TP785-869 - Abstract
ABSTRACTA novel semiconductor photocatalytic reaction system employing a photo-emitting enzyme as an internal light source is pro-posed in the present study. The system completely overturns common sense that conventional photocatalytic reactions must require irradiation from an external light source. A horseradish peroxidase (HRP) catalyzing oxidative bioluminescence reaction of luminol in the presence of H2O2 and manganate nanosheets (MNSs) with a narrow bandgap were utilized for an internal light source and semiconductor photocatalysts, respectively, and both of them coexisted in a same reactant solution. In other words, nano-sized light sources were highly dispersed in the solution, resulting in photo-excitation of MNSs over the entire solution. Photo-activated MNSs simultaneously caused oxidation and reduction, where platinum hexachloride anions (PtCl62-) were utilized as a model substance to be reacted photocatalytically. According to X-ray absorption near edge spectroscopy (XANES) of MNSs after the photocatalytic reaction, the anions were mainly transformed into solid phases of PtO2 and/or Pt(OH)4 by reacting with holes in MNSs. In contrast, a control experiment without HRP, i.e. a dark experiment, did not leave any evidence for photocatalytic reaction of PtCl62-. The detailed mechanism and the advantages/disadvantages of the proposed unique system are explained.
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- 2024
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17. Isatin-tethered halogen-containing acylhydrazone derivatives as monoamine oxidase inhibitor with neuroprotective effect
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Sunil Kumar, Jong Min Oh, Prabitha Prabhakaran, Abhimanyu Awasti, Hoon Kim, and Bijo Mathew
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Medicine ,Science - Abstract
Abstract Sixteen isatin-based hydrazone derivatives (IS1–IS16) were synthesized and assessed for their ability to inhibit monoamine oxidases (MAOs). All the molecules showed improved inhibitory MAO-B activity compared to MAO-A. Compound IS7 most potently inhibited MAO-B with an IC50 value of 0.082 μM, followed by IS13 and IS6 (IC50 = 0.104 and 0.124 μM, respectively). Compound IS15 most potently inhibited MAO-A with an IC50 value of 1.852 μM, followed by IS3 (IC50 = 2.385 μM). Compound IS6 had the highest selectivity index (SI) value of 263.80, followed by IS7 and IS13 (233.85 and 212.57, respectively). In the kinetic study, the Ki values of IS6, IS7, and IS13 for MAO-B were 0.068 ± 0.022, 0.044 ± 0.002, and 0.061 ± 0.001 μM, respectively, and that of IS15 for MAO-A was 1.004 ± 0.171 μM, and the compounds were reversible-type inhibitors. The lead compounds were central nervous system (CNS) permeable, as per parallel artificial membrane permeability assay (PAMPA) test results. The lead compounds were examined for their cytotoxicity and potential neuroprotective benefits in hazardous lipopolysaccharide (LPS)-exposed SH-SY5Y neuroblastoma cells. Pre-treatment with lead compounds enhanced anti-oxidant levels (SOD, CAT, GSH, and GPx) and decreased ROS and pro-inflammatory cytokine (IL-6, TNF-alpha, and NF-kB) production in LPS-intoxicated SH-SY5Y cells. To confirm the promising effects of the compound, molecular docking, dynamics, and MM-GBSA binding energy were used to examine the molecular basis of the IS7-MAO-B interaction. Our findings indicate that lead compounds are potential therapeutic agents to treat neurological illnesses, such as Parkinson's disease.
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- 2024
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18. Optimizing the photon ratio of red, green, and blue LEDs for lettuce seedlings: a mixture design approach
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Eunjeong Lim, Jong-Ok Kim, and Myung-Min Oh
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Optimization ,Lettuce seedlings ,LED ,Light quality ,Mixture design ,Response surface ,Plant culture ,SB1-1110 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background Light control technology has been developed and studied for decades in controlled environment agriculture (CEA) for successful crop production. The effects of the light spectrum on plant growth can vary because plants have spectral specific responses, and mixed light elicits interactive combination effects. Response surface methodology (RSM) can be utilized with the design of experiments to optimize a response influenced by multiple inputs with limited data. In this study, we aimed to identify the optimal photon ratio in combination of red (R), green (G), and blue (B) light-emitting diodes (LEDs) for growing lettuce seedlings using RSM and a seedling-indicating parameter by performing a similarity analysis of response surfaces that elucidated the response tendency of different factors, such as light quality. Results The highest shoot fresh weight was obtained from the R treatment (red LED 100%) at the end of the seedling stage. However, the RGB141 (photon ratio of R:G:B = 1:4:1) treatment during the seedling stage resulted in the highest shoot fresh weight at the final harvest. The value of the leaf area multiplied by the leaf chlorophyll concentration (SPAD) was selected as the seedling-indicating parameter. The optimal RGB photon ratio that maximized this parameter was R:G:B = 30.6:44.0:25.4, and this ratio was verified by conducting identical cultivation experiments. During the first 6 days after transplanting, SPAD gradually increased in R-treated seedlings, while the optimal treatment maintained the value at a higher constant level, which supported our result of shoot fresh weight at harvest. Conclusions Thus, we confirmed that the mixture design method allowed us to optimize the combined RGB photon ratios for the seedling stage in order to maximize the growth index of mature lettuce plants and to select an appropriate seedling-indicating parameter that represents the final harvest results to benefit crop production in CEA.
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- 2023
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19. PM2.5 Induces Pyroptosis via Activation of the ROS/NF-κB Signaling Pathway in Bronchial Epithelial Cells
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Ji-Young Kang, Hyunsu Choi, Jeong-Min Oh, Minsu Kim, and Dong-Chang Lee
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particulate matter 2.5 ,reactive oxygen species ,pyroptosis ,respiratory epithelium ,NF-kappa B ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: Fine particulate matter, PM2.5, is becoming a major threat to human health, particularly in terms of respiratory diseases. Pyroptosis is a recently discovered and distinct form of cell death, characterized by pore formation in the cell membrane and secretions of proinflammatory cytokines. There has been little research on the effect of PM2.5 on pyroptosis, especially in airway epithelium. We investigated whether PM2.5-related oxidative stress induces pyroptosis in bronchial epithelial cells and defined the underlying mechanisms. Materials and Methods: After exposure of a BEAS-2B cell line to PM2.5 concentration of 20 µg/mL, reactive oxygen species (ROS) levels, parameters related to pyroptosis, and NF-κB signaling were measured by Western blotting, immunofluorescence, and ELISA (Enzyme-linked immunosorbent assay). Results: PM2.5 induced pyroptotic cell death, accompanied by LDH (Lactate dehydrogenase) release and increased uptake of propidium iodide in a dose-dependent manner. PM2.5 activated the NLRP3-casp1-gasdermin D pathway, with resulting secretions of the proinflammatory cytokines IL-1β and IL-18. The pyroptosis activated by PM2.5 was alleviated significantly by NLRP3 inhibitor. In PM2.5-exposed BEAS-2B cells, levels of intracellular ROS and NF-κB p65 increased. ROS scavenger inhibited the expression of the NLRP3 inflammasome, and the NF-κB inhibitor attenuated pyroptotic cell death triggered by PM2.5 exposure, indicating that the ROS/NF-κB pathway is involved in PM2.5-induced pyroptosis. Conclusions: These findings show that PM2.5 exposure can cause cell injury by NLRP3-inflammasome-mediated pyroptosis by upregulating the ROS/NF-κB pathway in airway epithelium.
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- 2024
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20. Anti-Amnesic Effect of Agastache rugosa on Scopolamine-Induced Memory Impairment in Mice
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Sohi Kang, Nari Lee, Bokyung Jung, Huiyeong Jeong, Changjong Moon, Sang-Ik Park, Seungpil Yun, Teresa Yim, Jung Min Oh, Jae-Won Kim, Ji Hoon Song, Sungwook Chae, and Joong Sun Kim
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Agastache rugosa ,cognitive dysfunction ,scopolamine hydrobromide ,neuroprotection ,cholinergic system dysfunction ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Agastache rugosa, a traditional Asian herbal medicine, is primarily used for digestive problems; yet, its cognitive benefits remain unexplored. This study evaluated the anti-amnesic effects of A. rugosa extract (ARE) on scopolamine (SCO)-induced memory impairment in mice. Mice received 100 or 200 mg/kg ARE orally for 5 days, followed by SCO injection. The ARE demonstrated significant antioxidant (DPPH IC50: 75.3 µg/mL) and anti-inflammatory effects (NO reduction). Furthermore, the ARE significantly improved memory performance in the passive avoidance test (escape latency: 157.2 s vs. 536.9 s), the novel object recognition test (novel object preference: 47.6% vs. 66.3%) and the Morris water maze (time spent in the target quadrant: 30.0% vs. 45.1%). The ARE reduced hippocampal acetylcholinesterase activity (1.8-fold vs. 1.1-fold) while increasing choline acetyltransferase (0.4-fold vs. 1.0-fold) and muscarinic acetylcholine receptor subtype I (0.3-fold vs. 1.6-fold) expression. The ARE improved hippocampal neurogenesis via doublecortin- (0.4-fold vs. 1.1-fold) and KI-67-positive (6.3 vs. 12.0) cells. Therefore, the ARE exerts protective effects against cognitive decline through cholinergic system modulation and antioxidant activity, supporting its potential use as a cognitive enhancer.
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- 2024
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21. Correction: Inhibitory effect of human indoleamine 2,3-dioxygenase 1 (hIDO1) by kazinols of 1,3-diphenylpropane derivatives
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Taehoon Oh, Sunin Jung, Seon Min Oh, Mi Hyeon Park, Hyoung-Geun Kim, Su-Yeon Lee, Sung-Kyun Ko, and Hyung Won Ryu
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Agriculture (General) ,S1-972 ,Chemistry ,QD1-999 - Published
- 2024
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22. Investigating the Mechanisms of Intradermal Injection for Easier 'Skin Booster' Treatment: A Fluid Mechanics Approach to Determine Optimal Delivery Method
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Seung Min Oh, MD, Yongkoo Lee, PhD, Jae Hyuk Lee, DS, and Myungjune Oh, MD
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Surgery ,RD1-811 - Abstract
Background:. The use of “skin boosters” for rejuvenating aged skin is widely used. However, the accurate injection of the skin booster into the dermal layer remains a challenge due to the density of the dermis. The purpose of this study was to investigate the optimal mechanical variables of delivery that enabled correct targeting of the product to the dermis for optimal results. Methods:. We investigated the impact of mechanical variables (syringe diameter, needle diameter and length, and viscosity of the skin booster) on the force required for intradermal injection in porcine skin. The correlation between these variables and the injection force was examined as well. Results:. The results show that smaller syringe diameters, larger needle diameters, shorter needle lengths, and lower viscosity of the skin boosters reduce the injection force needed for intradermal injections. Conclusions:. During the administration of skin booster injections, clinicians should take into account optimal conditions that facilitate intradermal injections, thus maximizing rejuvenating outcomes. Furthermore, manufacturers of skin boosters should formulate the products with decreased viscosity and provide the product in conjunction with appropriate needles and syringes, designed to optimize ease of injection.
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- 2024
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23. Freeze-cast Mg-Fe-CO3 nano-layered double hydroxide/alginate composite scaffolds for bone substitution: porous architecture and mechanical properties
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Prescillia Lagarrigue, Jae-Min Oh, Jing Xie, Christophe Tenailleau, Benjamin Duployer, Sophie Cazalbou, Dominique Poquillon, Christophe Drouet, and Jérémy Soulié
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Porous scaffolds ,Composite ,Layered Double Hydroxide ,Bone Tissue Engineering ,Freeze-casting ,Technology - Abstract
Layered Double Hydroxides (LDH) are relevant inorganic materials for biomedical application thanks to both their tunable chemical composition and their lamellar structure allowing molecules or ions intercalation in the interlayer spaces. However, their brittleness and thermal sensibility limit the fabrication of 3D materials based on LDH, making it challenging, especially to prepare scaffolds for bone tissue engineering that require a macroporous structure for cell colonization and sufficient mechanical properties to be handled/cut by surgeons. To overcome these drawbacks, this study describes the preparation of 3D scaffolds based on the association of fully biocompatible LDH with an alginate matrix processed by freeze-casting, and leading to macroporous materials with a porosity compatible with cell colonization. To the best of our knowledge, the fabrication of such composite scaffolds by freeze-casting associated with a fine multiscale and systematic characterization was never described in the literature. Thus, this work first focused on the successful synthesis of Mg-Fe-CO3 layered double hydroxide nanoparticles, as confirmed by physicochemical characterizations (XRD, FTIR, SEM, DLS). Then, the resulting nano-LDH were associated with an alginate matrix to generate 3D composite scaffolds by freeze-casting. In order to evaluate the effect of nano-LDH content on the scaffold porous structure and mechanical properties, various compositions (nano-LDH/alginate ratio) were tested, and the structure and mechanical properties of the resulting scaffolds were characterized (SEM, X-Ray microtomography, compression tests). Results allowed us to identify an optimal nano-LDH/alginate composition (ratio 1:1) leading to 3D macroporous scaffolds combining suitable anisotropic microporosity for cell colonization and sufficient mechanical properties for non-bearing bone applications, while allowing for their manipulation without risks of collapse.
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- 2024
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24. High-Intensity Focused Ultrasound Increases Facial Adipogenesis in a Swine Model via Modulation of Adipose-Derived Stem Cell Cilia
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Kyung-A Byun, Hyoung Moon Kim, Seyeon Oh, Sosorburam Batsukh, Sangsu Lee, Myungjune Oh, Jeongwoo Lee, Ran Lee, Jae Woo Kim, Seung Min Oh, Jisun Kim, Geebum Kim, Hyun Jun Park, Hanbit Hong, Jehyuk Lee, Sang-Hyun An, Sung Suk Oh, Yeon-Seop Jung, Kuk Hui Son, and Kyunghee Byun
- Subjects
adipogenesis ,cilia ,high-intensity focused ultrasound ,zygomatic arch ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Decreased medial cheek fat volume during aging leads to loss of a youthful facial shape. Increasing facial volume by methods such as adipose-derived stem cell (ASC) injection can produce facial rejuvenation. High-intensity focused ultrasound (HIFU) can increase adipogenesis in subcutaneous fat by modulating cilia on ASCs, which is accompanied by increased HSP70 and decreased NF-κB expression. Thus, we evaluated the effect of HIFU on increasing facial adipogenesis in swine (n = 2) via modulation of ASC cilia. Expression of CD166, an ASC marker, differed by subcutaneous adipose tissue location. CD166 expression in the zygomatic arch (ZA) was significantly higher than that in the subcutaneous adipose tissue in the mandible or lateral temporal areas. HIFU was applied only on the right side of the face, which was compared with the left side, where HIFU was not applied, as a control. HIFU produced a significant increase in HSP70 expression, decreased expression of NF-κB and a cilia disassembly factor (AURKA), and increased expression of a cilia increasing factor (ARL13B) and PPARG and CEBPA, which are the main regulators of adipogenesis. All of these changes were most prominent at the ZA. Facial adipose tissue thickness was also increased by HIFU. Adipose tissue volume, evaluated by magnetic resonance imaging, was increased by HIFU, most prominently in the ZA. In conclusion, HIFU increased ASC marker expression, accompanied by increased HSP70 and decreased NF-κB expression. Additionally, changes in cilia disassembly and length and expression of adipogenesis were observed. These results suggest that HIFU could be used to increase facial volume by modulating adipogenesis.
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- 2024
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25. Supervisory Prompt Training.
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Jean Ghislain Billa, Min Oh, and Liang Du
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- 2024
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26. Inhibition of Monoamine Oxidases by Pyridazinobenzylpiperidine Derivatives
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Jong Min Oh, Yaren Nur Zenni, Zeynep Özdemir, Sunil Kumar, Semanur Kılıç, Mevlüt Akdağ, Azime Berna Özçelik, Hoon Kim, and Bijo Mathew
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monoamine oxidase inhibitors ,pyridazinone ,benzylpiperidine ,molecular docking ,Organic chemistry ,QD241-441 - Abstract
Monoamine oxidase inhibitors (MAOIs) have been crucial in the search for anti-neurodegenerative medications and continued to be a vital source of molecular and mechanistic diversity. Therefore, the search for selective MAOIs is one of the main areas of current drug development. To increase the effectiveness and safety of treating Parkinson’s disease, new scaffolds for reversible MAO-B inhibitors are being developed. A total of 24 pyridazinobenzylpiperidine derivatives were synthesized and evaluated for MAO. Most of the compounds showed a higher inhibition of MAO-B than of MAO-A. Compound S5 most potently inhibited MAO-B with an IC50 value of 0.203 μM, followed by S16 (IC50 = 0.979 μM). In contrast, all compounds showed weak MAO-A inhibition. Among them, S15 most potently inhibited MAO-A with an IC50 value of 3.691 μM, followed by S5 (IC50 = 3.857 μM). Compound S5 had the highest selectivity index (SI) value of 19.04 for MAO-B compared with MAO-A. Compound S5 (3-Cl) showed greater MAO-B inhibition than the other derivatives with substituents of -Cl > -OCH3 > -F > -CN > -CH3 > -Br at the 3-position. However, the 2- and 4-position showed low MAO-B inhibition, except S16 (2-CN). In addition, compounds containing two or more substituents exhibited low MAO-B inhibition. In the kinetic study, the Ki values of S5 and S16 for MAO-B were 0.155 ± 0.050 and 0.721 ± 0.074 μM, respectively, with competitive reversible-type inhibition. Additionally, in the PAMPA, both lead compounds demonstrated blood–brain barrier penetration. Furthermore, stability was demonstrated by the 2V5Z-S5 complex by pi–pi stacking with Tyr398 and Tyr326. These results suggest that S5 and S16 are potent, reversible, selective MAO-B inhibitors that can be used as potential agents for the treatment of neurological disorders.
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- 2024
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27. TBHQ Alleviates Particulate Matter-Induced Pyroptosis in Human Nasal Epithelial Cells
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Ji-Sun Kim, Hyunsu Choi, Jeong-Min Oh, Sung Won Kim, Soo Whan Kim, Byung Guk Kim, Jin Hee Cho, Joohyung Lee, and Dong Chang Lee
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fine particulate matter ,human nasal epithelial cells ,pyroptosis ,NLRP3 inflammasome ,tert-butylhydroquinone ,Chemical technology ,TP1-1185 - Abstract
Pyroptosis represents a type of cell death mechanism notable for its cell membrane disruption and the subsequent release of proinflammatory cytokines. The Nod-like receptor family pyrin domain containing inflammasome 3 (NLRP3) plays a critical role in the pyroptosis mechanism associated with various diseases resulting from particulate matter (PM) exposure. Tert-butylhydroquinone (tBHQ) is a synthetic antioxidant commonly used in a variety of foods and products. The aim of this study is to examine the potential of tBHQ as a therapeutic agent for managing sinonasal diseases induced by PM exposure. The occurrence of NLRP3 inflammasome-dependent pyroptosis in RPMI 2650 cells treated with PM < 4 µm in size was confirmed using Western blot analysis and enzyme-linked immunosorbent assay results for the pyroptosis metabolites IL-1β and IL-18. In addition, the inhibitory effect of tBHQ on PM-induced pyroptosis was confirmed using Western blot and immunofluorescence techniques. The inhibition of tBHQ-mediated pyroptosis was abolished upon nuclear factor erythroid 2-related factor 2 (Nrf2) knockdown, indicating its involvement in the antioxidant mechanism. tBHQ showed potential as a therapeutic agent for sinonasal diseases induced by PM because NLRP3 inflammasome activation was effectively suppressed via the Nrf2 pathway.
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- 2024
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28. Functional Properties of the Ziv-Zakai bound with Arbitrary Inputs.
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Min-Oh Jeong, Alex Dytso, and Martina Cardone
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- 2023
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29. Assessment of iridoid profiles in the growth period of aerial parts of Pseudolysimachion rotundum var. subintegrum and their antioxidant and MUC5AC inhibitory potential
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Soobin Song, Doo-Young Kim, Seon Min Oh, So-Yeun Woo, Il-joo Kim, Mun-Ock Kim, Ji-Yoon Park, Namho Kim, Hae-Young Kim, Juhee Lee, Sang Yoon Kim, Bang Yeon Hwang, Hyung Won Ryu, and Sei-Ryang Oh
- Subjects
Pseudolysimachion rotundum var. Subintegrum ,Growth stages ,Quality control ,Antioxidant ,MUC5AC ,Agriculture (General) ,S1-972 ,Chemistry ,QD1-999 - Abstract
Abstract YPL-001 is a drug substance of Pseudolysimachion rotundum var. subintegrum and has been reported to be a potent COPD inhibitor. For the first time, this study demonstrated a correlation among the iridoid constituents, antioxidants, and MUC5AC inhibition activities in P. rotundum during different growth stages (5 to 11 weeks). Single-factor extraction was used to optimize the plant extraction conditions to maximize the major iridoid constituents (70% ethanol, 40 °C, 1 h); isolated metabolites 1–6 were identified using nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS). The contents of each metabolite and antioxidant/MUC5AC inhibition effects were markedly changed according to the growth stages, especially for catalposide (2, 5.97 → 10.99 mg/g, 1.8-fold) and isovanillyl catapol (5, 4.42 → 20.00 mg/g, 4.5-fold), which were the predominant substances in August. Our results indicated that YPL-001 could potentially contribute to enhancing the P. rotundum value in accumulated iridoids at the growth stage and the biological effect aspects to develop industrial medicinal crops.
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- 2023
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30. Myositis unrelated to the inoculation site after COVID-19 vaccination: a case report
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Jung Won Han, Jae Min Oh, Dae Hee Lee, and Young Dae Jeon
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covid-19 ,vaccination ,myositis ,adverse effects ,Orthopedic surgery ,RD701-811 - Abstract
We describe the case of a 49-year-old right hand-dominant woman with myositis of the biceps brachii muscle unrelated to the inoculation site following Pfizer-BioNTech COVID-19 vaccination on the deltoid muscle of the left shoulder. Coronavirus disease 2019 (COVID-19) pandemic has involved global spread, and different vaccines including inactivated, protein, vectored, and nucleic acid vaccines have been developed and administered. Common side effects of COVID-19 vaccines include general manifestations such as headache, fever, and fatigue, and various musculoskeletal symptoms. Here, we present a case of myositis occurring in the biceps brachii muscle unrelated to the inoculation site, which has not been reported previously, accompanied by a literature review. Level of evidence V.
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- 2023
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31. Correlation Between Articulatory Diadochokinetic Parameters and Dysphagia Parameters in Subacute Stroke Patients
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Back Min Oh, Hyun Seok, Sang-Hyun Kim, Seung Yeol Lee, Su Jung Park, Beom Jin Kim, and Hyun Jung Kim
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dysarthria ,deglutition disorders ,phonation ,stroke ,Medicine - Abstract
Objective To determine correlations of alternation motor rate (AMR), sequential motor rate (SMR), and maximum phonation time (MPT) with the severity of dysphagia in subacute stroke patients. Methods This was a retrospective chart review study. Data of 171 subacute stroke patients were analyzed. Patient’s AMR, SMR, and MPT data were collected from their language evaluations. Video fluoroscopic swallowing study (VFSS) was done. Data of dysphagia scales including penetration-aspiration scale (PAS), American Speech-Language-Hearing Association National Outcomes Measurement System (ASHA-NOMS) scale, clinical dysphagia scale (CDS), and videofluoroscopic dysphagia scale (VDS) were obtained. AMR, SMR, and MPT were compared between a non-aspirator group and an aspirator group. Correlations of AMR, SMR, and MPT with dysphagia scales were analyzed. Results AMR ("ka"), SMR, and modified Rankin Scale were significant associated factors between non-aspirator group and aspirator group, while AMR ("pa"), AMR ("ta"), and MPT were not. AMR, SMR, and MPT showed significant correlations with PAS score, ASHA-NOMS scale, CDS, VDS oral, and VDS pharyngeal scores. The cut-off value for distinguishing non-aspirator group and aspiration group was 18.5 for AMR ("ka") (sensitivity of 74.4%, specificity of 70.8%) and 7.5 for SMR (sensitivity of 89.9%, specificity of 61.0%). AMR and SMR were significantly lower in before-swallow aspiration group. Conclusion Articulatory diadochokinetic tasks that can be easily performed at the bedside would be particularly helpful in determining the oral feeding possibility of subacute stroke patients who cannot undergo VFSS, which is the gold standard for dysphagia assessment.
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- 2023
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32. Impact of annealing on material and electrical characteristics of lithium phosphate thin films on silicon carbide
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Hyung-Jin Lee, Soo-Young Moon, Hee-Jae Lee, Dong-Wook Byun, Seung-Woo Jung, Michael A. Schweitz, Minkyung Kim, Jong-Min Oh, Weon Ho Shin, Chulhwan Park, and Sang-Mo Koo
- Subjects
Lithium phosphate ,4H–SiC ,Thin film ,Post-deposition annealing ,RF sputtering ,Mining engineering. Metallurgy ,TN1-997 - Abstract
In this study, we investigated the influence of post-deposition annealing (PDA) process on lithium phosphate (Li3PO4) solid-state thin films on silicon carbide (SiC) substrate in terms of materials and electrical properties. Li3PO4 thin films were deposited through radio frequency (RF) sputtering and post-deposition annealing was performed in a temperature range of 200–400 °C. The Li3PO4 thin films show typical amorphous structures, and no changes are observed even after 400 °C PDA process. The Li 1 s/P 2p ratio varies with changing the annealing temperature and the highest Li is detected under 300 °C annealing, where the ionic conductivity increases to 1.00 × 10−4 S/mm at the same temperature. The rectification ratio of the 300 °C annealed device is obtained as 1.45 × 103, which is 23 times higher value than as-deposited Li3PO4/SiC device without annealing. This result suggests that the delicate control of Li3PO4 deposition could provide a significant enhancement on the electrical devices and the solid electrolyte batteries.
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- 2023
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33. Risk factors and clinical features for pulmonary paragonimiasis-associated pneumothorax.
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Yunhong Song, Jeongmin Lee, Wonchang Hahn, Yujeong Jang, Seungwon Na, Sang-Min Oh, Joo-Hee Hwang, Chang-Seop Lee, Yeong Hun Choe, and Jeong-Hwan Hwang
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundPulmonary paragonimiasis, a food-borne zoonotic helminthiasis, is a parasitic disease of the lung caused by infection with trematodes species of the genus Paragonimus. Although pneumothorax has been reported as occuring with paragonimiasis, to date no study has been performed concerning the clinical features and predictive risk factors for this condition.MethodsThis retrospective study, which aims to fill this gap, was conducted at Jeonbuk National University Hospital. All patients (aged ≥19 years) were diagnosed with paragonimiasis between May 2011 and December 2021. Medical records were reviewed and information concerning age, sex, vital signs, underlying diseases, clinical signs and symptoms, laboratory findings, radiologic findings, treatment, and clinical outcomes was collected. An odds ratio (OR) for the risk factors associated with pneumothorax was calculated using the binary logistic regression model.ResultsAmong 179 consecutive patients diagnosed with pulmonary paragonimiasis, the postive rate of pneumothorax was 10.6% (19/179). Pneumothorax occurred mostly in the right lung (78.9%, 15/19), and intrapulmonary parenchymal lesions showed an ipsilateral relationship with pneumothorax (94.7%, 18/19). Fifteen patients (78.9%, 15/19) of pneumothorax associated with pulmonary paragonimiasis are accompanied by pleural effusion. Most of patients with pneumothorax (89.5%, 17/19) underwent chest tube insertion as a first treatment. Three patients (15.8%) showed relapses but in no case was a death recorded. Asthma (odds ratio [OR] 8.10, 95% confidence interval [CI] 1.43-45.91), chest pain (OR 8.15, 95% CI 2.70-24.58), and intrapulmonary lesions (OR 8.94, 95% CI 1.12-71.36) were independent risk factors for pulmonary paragonimiasis-associated pneumothorax.ConclusionsOur findings suggest that clinicians should keep in mind the possibility of pneumothorax when approached by patients with pulmonary paragonimiasis complaining of chest pain, accompanied by intrapulmonary lesions or with asthma as an underlying disease.
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- 2023
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34. 1062 GI-102, a novel CD80-IgG4-IL2v3 fusion protein driving lymphocyte expansion and anti-cancer potential through regulation of immune cells in the tumor microenvironment
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Jihyun Kim, Kyungwha Lee, Min Park, Young Min Oh, Wonjae Lee, Myoung Ho Jang, Young Jun Koh, Jisoo Kim, Kayoung Shin, Seoho Kim, Haejong Lee, Yuseong Lee, Eunjin Lee, Sungman Oh, Chong Woo Park, Yaein Amy Shim, Young-Gyu Cho, and Kookhwan Kim
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2023
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35. 1072 GI-108, a novel bispecific fusion protein augments anti-tumor immunity by alleviating immunosuppressive adenosine pathway in CD8+ T cells
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Kyungwha Lee, Min Park, Young Min Oh, Wonjae Lee, Myoung Ho Jang, Young Jun Koh, Sanghee Lee, Jisoo Kim, Kayoung Shin, Seoho Kim, Haejong Lee, Yuseong Lee, Eunjin Lee, Chong Woo Park, Yaein Amy Shim, Young-Gyu Cho, Kookhwan Kim, Jongil Kim, Suyoun Park, and Danbee Ha
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2023
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36. DeepGeni: deep generalized interpretable autoencoder elucidates gut microbiota for better cancer immunotherapy
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Min Oh and Liqing Zhang
- Subjects
Medicine ,Science - Abstract
Abstract Recent studies revealed that gut microbiota modulates the response to cancer immunotherapy and fecal microbiota transplantation has clinical benefits in melanoma patients during treatment. Understanding how microbiota affects individual responses is crucial for precision oncology. However, it is challenging to identify key microbial taxa with limited data as statistical and machine learning models often lose their generalizability. In this study, DeepGeni, a deep generalized interpretable autoencoder, is proposed to improve the generalizability and interpretability of microbiome profiles by augmenting data and by introducing interpretable links in the autoencoder. DeepGeni-based machine learning classifier outperforms state-of-the-art classifier in the microbiome-driven prediction of responsiveness of melanoma patients treated with immune checkpoint inhibitors. Moreover, the interpretable links of DeepGeni elucidate the most informative microbiota associated with cancer immunotherapy response. DeepGeni not only improves microbiome-driven prediction of immune checkpoint inhibitor responsiveness but also suggests potential microbial targets for fecal microbiota transplant or probiotics improving the outcome of cancer immunotherapy.
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- 2023
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37. Survey on Protocol Achitectures for Cellular-based Low Earth Orbit Satellite Communications.
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Yousun Hwang and Sung-Min Oh
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- 2023
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38. Trends and Applications of Robotics Development in Virtual Environments.
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Joon Young Kim and Jeong Min Oh
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- 2023
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39. Service Procedures for On-board UEs in the 3GPP Mobile IAB Systems.
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Yousun Hwang and Sung-Min Oh
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- 2023
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40. 5G URLLC evolving towards 6G: research directions and vision.
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Gweon Do Jo, JaeSheung Shin, and Sung-Min Oh
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- 2023
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41. Controlled Molecular Arrangement of Cinnamic Acid in Layered Double Hydroxide through pi-pi Interaction for Controlled Release
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Taeho Kim, Seung-Min Paek, Kang-Kyun Wang, Jin Kuen Park, Fabrice Salles, and Jae-Min Oh
- Subjects
layered double hydroxide ,molecular arrangement ,phenolic acid ,cinnamic acid ,π-π interaction ,release ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Cinnamic acid (CA) was successfully incorporated into Zn-Al layered double hydroxide (LDH) through coprecipitation. The CA moiety was stabilized in the interlayer space through not only electrostatic interaction but also intermolecular π-π interaction. It was noteworthy that the CA arrangement was fairly independent of the charge density of LDH, showing the important role of the layer–CA and CA-CA interactions in molecular stabilization. Computer simulations using the Monte Carlo method as well as analytical approaches including infrared, UV-vis spectroscopy, and differential scanning calorimetry showed the existence of intermolecular interaction. In order to reinforce molecular stabilization, a neutral derivative of CA, cinnamaldehyde (CAD), was additionally incorporated into LDH. It was clearly shown that CAD played a role as a π-π interaction mediator to enhance the stabilization of CA. The time-dependent release of CA from LDH was first governed by the layer charge density of LDH; however, the existence of CAD provided additional stabilization to the CA arrangement to slow down the release kinetics.
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- 2024
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42. Mitigation of Silicon Contamination in Fuel Cell Gasket Materials through Silica Surface Treatment
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Yoo Lim Sim, Jaewon Lee, Su Min Oh, Dong Beom Kim, Kijong Kim, Sung-Hyeon Baeck, Sang Eun Shim, and Yingjie Qian
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silicone rubber gasket ,silica surface modification ,silicone elution ,Organic chemistry ,QD241-441 - Abstract
Gaskets and seals are essential components in the operation of proton exchange membrane (PEM) fuel cells and are required for keeping hydrogen and air/oxygen within their individual compartments. The durability of these gaskets and seals is necessary, as it influences not only the lifespan but also the electrochemical efficiency of the PEM fuel cell. In this study, the cause of silicon leaching from silicone gaskets under simulated fuel cell conditions was investigated. Additionally, to reduce silicon leaching, the silica surface was treated with methyltrimethoxysilane, vinyltriethoxysilane, and (3,3,3-trifluoropropyl)trimethoxysilane. Changes in the silica surface chemistry were investigated by scanning electron microscopy, energy dispersive X-ray spectroscopy, thermogravimetric analysis, elemental analysis, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy. Inductively coupled plasma-optical emission spectroscopy analysis revealed that surface-treated silica was highly effective in reducing silicon leaching.
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- 2024
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43. Controlled molecular arrangement of easily aggregated deoxycholate with layered double hydroxide
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Kyounghyoun Lee, Jing Xie, Hyeonjin Park, Hyun Jung, and Jae-Min Oh
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deoxycholate ,aggregation ,layered double hydroxide ,molecular arrangement ,Science - Abstract
Deoxycholate (DA) is a natural emulsifying agent involved in the absorption of dietary lipids. Due to the facial distribution of hydrophobic-hydrophilic region, DA easily aggregates under ambient conditions, and this property hinders the practical application of DA in clinical applications. In this study, we found that the molecular arrangement of DA molecules could be controlled by using layered double hydroxide (LDH) under a specific reaction condition. The effect of reaction methods such as co-precipitation, ion exchange and reconstruction on the molecular arrangement of DA was investigated by X-ray diffraction, Fourier-transform infrared spectroscopy, high-resolution transmission electron microscopy and differential scanning calorimetry. It was demonstrated that the self-aggregation of DA molecules could be suppressed by the oriented arrangement of DA between the gallery space of LDH. The DA moiety was well stabilized in the LDH layers due to the electrostatic interaction between DA molecules and LDH layers. The most ordered arrangement of DA molecules was observed when DA was incorporated into LDH via a reconstruction method. The DA molecules arranged in LDH via reconstruction did not show significant exothermic or endothermic behaviour up to 400°C, showing that the DA moiety lost its intermolecular attraction in between LDH layers.
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- 2023
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44. Methyl lucidone inhibits airway inflammatory response by reducing TAK1 activity in human bronchial epithelial NCI–H292 cells
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Eun Sol Oh, Hyunju Ro, Hyung Won Ryu, Yu Na Song, Ji-Yoon Park, Namho Kim, Hae-Young Kim, Seon Min Oh, Su-Yeon Lee, Doo-Young Kim, Sooil Kim, Sung-Tae Hong, Mun-Ock Kim, and Su Ui Lee
- Subjects
Methyl lucidone ,Inflammatory lung disease ,TAK1 ,NF-κB ,p38 MAP kinase ,Human bronchial epithelial cell ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: Methyl lucidone (ML), a methyl derivative of lucidone, has anti-inflammatory properties. However, the molecular mechanisms that reduce the inflammatory effect of ML in human lung epithelial cells remain unkown. This study aimed to elucidate the molecular mechanisms underlying the anti-inflammatory effect of ML. Methods: Four compounds (ML, methyl linderone, kanakugiol, and linderone) from Lindera erythrocarpa Makino were evaluated for their ability to reduce MUC5AC secretion levels in phorbol-12-myristate-13-acetate (PMA)-stimulated NCI–H292 cells using ELISA. The expression and secretion levels of inflammatory response-related proteins were analyzed using quantitative reverse transcription-PCR, ELISA, and western blotting. To determine whether ML directly regulates TGF-β-activated kinase 1 (TAK1), we performed an in vitro kinase assay. Results: ML treatment effectively reduced the levels of inflammatory cytokines, including interleukin-1β and TNF-α, increased by stimulation. Furthermore, ML downregulated the pathway cascade of both IκB kinase (IKK)/NF-κB and p38 mitogen-activated protein (MAP) kinase/CREB by inhibiting the upstream kinase TAK1. An in vitro kinase analysis confirmed that ML treatment significantly reduced the kinase activity of TAK1. Conclusion: ML pretreatment repressed the PMA-stimulated inflammation reaction by reducing the TAK1-mediated IKK/NF-κB and p38 MAP kinase/CREB signaling. These findings suggest that ML may improve respiratory health and can be used as a dietary supplement or functional food to prevent inflammatory lung diseases.
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- 2023
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45. SC-Fano Decoding of Polar Codes
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Jeong, Min-Oh and Hong, Song-Nam
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Electrical Engineering and Systems Science - Signal Processing ,Computer Science - Information Theory - Abstract
In this paper, we present a novel decoding algorithm of a polar code, named SC-Fano decoding, by appropriately incorporating the Fano sequential decoding into the standard successive-cancellation (SC) decoding. The proposed SC-Fano decoding follows the basic procedures of SC decoding with an additional operation to evaluate the reliability (or belief) of a current partial path. Specifically, at every decoding stage, it decides whether to move forward along a current path or move backward to find a more likelihood path. In this way, SC-Fano decoding can address the inherent drawback of SC decoding such as one wrong-decision will surely lead to a wrong codeword. Compared with the other improvements of SC decoding as SC-List (SCL) and SC-Stack (SCS) decodings, SC-Fano decoding has much lower memory requirement and thus is more suitable for hardware implementations. Also, SC- Fano decoding can be viewed as an efficient implementation of SC-Flip (SCF) decoding without the cost of cyclic-redundancy-code (CRC). Simulation results show that the proposed SC-Fano decoding significantly enhances the performance of SC decoding with a similar complexity as well as achieves the performance of SCL decoding with a lower complexity., Comment: 5pages, 5figures, conference
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- 2019
46. Association between the Korean Triage and Acuity Scale level and severity of children with dyspnea in the emergency department
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Kwansoo Han, Eui-Soon Kim, Young Min Oh, Yeon Young Kyong, Kiwook Kim, Hyun Ho Jeong, Jung Taek Park, Joo Suk Oh, Se Min Choi, and Kyoung Ho Choi
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critical illness ,dyspnea ,epidemiology ,pediatric emergency medicine ,triage ,Medicine - Abstract
Purpose Triage tools play a vital role in classifying the severity of children in emergency departments (EDs). We investigated the association between the Korean Triage and Acuity Scale (KTAS) and severity of dyspnea in the ED. Methods We conducted a retrospective study of children aged 3-14 years with dyspnea who visited the ED from January 2015 through December 2021. They were divided into severe (KTAS level 1-3) and non-severe (KTAS level 4-5) groups. Between the groups, we compared the clinical characteristics, including age, sex, associated symptoms, vital signs, route of visit, treatment at ED, and outcomes. Results Among a total of 468 children with dyspnea, 267 and 201 were assigned to the severe and non-severe groups, respectively. The severe group had higher frequencies of fever (21.7% vs. 13.9%; P = 0.031), cough (53.2% vs. 43.3%; P = 0.034), systemic steroids (42.3% vs. 25.9%; P < 0.001), intravenous fluids (47.6% vs. 25.4%; P < 0.001), oxygen therapy (16.5% vs. 6.5%; P = 0.001), inotropics (4.1% vs. 1.0%; P = 0.042), and hospitalization (24.7% vs. 11.9%; P = 0.002). The severe group also showed a higher mean heart rate, respiratory rate, and temperature, and lower mean oxygen saturation (all Ps < 0.001). Among these findings, fever, heart rate, respiratory rate, temperature, intravenous fluids, oxygen therapy, inotropics, and hospitalization remained significantly different between the groups after defining the severe group as a KTAS level 1-2. Conclusion This study shows the association between KTAS and severity of dyspnea in the ED. Therefore, KTAS may reflect not only the initial clinical conditions but also emergency measures and outcomes in children with dyspnea who visit EDs.
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- 2022
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47. Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
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Sachithra Thazhathuveedu Sudevan, Jong Min Oh, Mohamed A. Abdelgawad, Mohammed A. S. Abourehab, T. M. Rangarajan, Sunil Kumar, Iqrar Ahmad, Harun Patel, Hoon Kim, and Bijo Mathew
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Medicine ,Science - Abstract
Abstract The inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO-B isoform more potently than hMAO-A. Furthermore, the majority of the molecules showed strong inhibitory actions against hMAO-B at 10 μM level with residual activities of less than 50%. Compound B10 has an IC50 value of 0.067 μM, making it the most potent inhibitor of hMAO-B, trailed by compound B15 (IC50 = 0.12 μM). The thiophene substituent (B10) in the A-ring exhibited the strongest hMAO-B inhibition structurally, however, increased residue synthesis did not result in a rise in hMAO-B inhibition. In contrast, the benzyl group at the para position of the B-ring displayed more hMAO-B inhibition than the other positions. Compounds B10 and B15 had relatively high selectivity index (SI) values for hMAO-B (504.791 and 287.600, respectively). Ki values of B10 and B15 were 0.030 ± 0.001 and 0.033 ± 0.001 μM, respectively. The reversibility study showed that B10 and B15 were reversible inhibitors of hMAO-B. PAMPA assay manifested that the benzyloxy chalcones (B10 and B15) had a significant permeability and CNS bioavailability with Pe value higher than 4.0 × 10–6 cm/s. Both compounds were stabilized in protein–ligand complexes by the π-π stacking, which enabled them to bind to the hMAO-B enzyme's active site incredibly effectively. The hMAO-B was stabilized by B10- and B15-hMAO-B complexes, with binding energies of − 74.57 and − 87.72 kcal/mol, respectively. Using a genetic algorithm and multiple linear regression, the QSAR model was created. Based on the best 2D and 3D descriptor-based QSAR model, the following statistics were displayed: R2 = 0.9125, Q2 loo = 0.8347. These findings imply that B10 and B15 are effective, selective, and reversible hMAO-B inhibitors.
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- 2022
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48. A simulation-based continuing professional development course for the first 5 minutes of cardiac arrest in the resource-limited local clinics
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Chang Hyun Cho, Young-Min Kim, Young Min Oh, Ji-Hoon Kim, Hyo-Joon Kim, Ji Eun Kim, and Sung A Lee
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professional retraining ,high fidelity simulation training ,short-term courses ,heart arrest ,outpatient clinics ,Education (General) ,L7-991 ,Medicine (General) ,R5-920 - Abstract
Purpose Using simulation in continuing professional development (CPD) courses for local practitioners is uncommon in Korea. The aim of our study was to evaluate the responses of the local practitioners for a simulation-based short CPD course. Methods Following the targeted needs assessment of local practitioners, we developed and implemented a 3-hour simulation-based CPD course for the first 5 minutes of cardiac arrest in the resource-limited local clinics. We evaluated the participant’s responses to the course using a questionnaire. Results During the 3-year implementation period, 115 practitioners participated in 10 courses, and 113 (98%) responded to the questionnaire. The overall course satisfaction (10-point scale) was very positive (10 in 93 [82.3%], 9 in 19 [16.8%], and 8 in 1 [0.8%]). The level (5-point scale) of recommendation to the others was also high (5 in 103 [91.2%] and 4 in 10 [8.8%]). Many participants positively commented on the authentic practical experience of the uncommon crisis in their contexts. Conclusion A simulation-based short CPD course for in-hospital cardiac arrest could provide an authentic practical experience for local practitioners working in resource-limited clinics.
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- 2022
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49. Clinical application of the Panbio™ COVID-19 Ag rapid test device and SSf-COVID19 kit for the detection of SARS-CoV-2 infection
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Sang-Min Oh, Jee-Soo Lee, Hyeon Jae Jo, Donghwan Kim, Dohyeon Park, Young Hoon Hwang, Yunsang Choi, Chan Mi Lee, Seungjae Lee, Euijin Chang, Eunyoung Lee, Taek Soo Kim, Moon-Woo Seong, Pyoeng Gyun Choe, and Nam Joong Kim
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COVID-19 ,SARS-CoV-2 ,RT-PCR ,Saliva ,Antigen ,Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Objective We evaluated the sensitivity and specificity of the Panbio™ COVID-19 Ag rapid test device using nasal swabs and those of the SSf-COVID19 kit, one of RT-PCR tests, using saliva specimens. These tests were compared with RT-PCR tests using nasopharyngeal swabs for the diagnosis of SARS-CoV-2 infection. The three diagnostic tests were simultaneously conducted for patients aged ≥ 18 years, who were about to be hospitalized or had been admitted for COVID-19 confirmed by RT-PCR in two research hospitals from August 20 to October 29, 2021. Nasal swabs were tested using the Panbio™ COVID-19 Ag rapid test device. More than 1 mL of saliva was self-collected and tested using the SSf-COVID19 kit. Results In total, 157 patients were investigated; 124 patients who were about to be hospitalized and 33 patients already admitted for COVID-19. The overall sensitivity and specificity of the Panbio™ COVID-19 Ag rapid test device with nasal swabs were 64.7% (95% confidence interval [CI] 47.9–78.5%) and 100.0% (95% CI 97.0–100.0%), respectively. The median time to confirm a positive result was 180 s (interquartile range 60–255 s). The overall sensitivity and specificity of the SSf-COVID19 kit with saliva specimens were 94.1% (95% CI 80.9–98.4%) and 100.0% (95% CI 97.0–100.0%), respectively.
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- 2022
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50. Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1
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Scisung Chung, Mi-Sun Kang, Dauren S. Alimbetov, Gil-Im Mun, Na-Oh Yunn, Yunjin Kim, Byung-Gyu Kim, Minwoo Wie, Eun A. Lee, Jae Sun Ra, Jung-Min Oh, Donghyun Lee, Keondo Lee, Jihan Kim, Seung Hyun Han, Kyong-Tai Kim, Wan Kyun Chung, Ki Hyun Nam, Jaehyun Park, ByungHoon Lee, Sunghoon Kim, Weixing Zhao, Sung Ho Ryu, Yun-Sil Lee, Kyungjae Myung, and Yunje Cho
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Science - Abstract
Aminoacyl-tRNA synthetases possess unique domains. In this study the structure of the vertebrate IARS1 and EARS1 complex reveals that vertebrate IARS1 protects the DNA repair factor BRCA1 from proteolytic degradation via its UBX-fold domain.
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- 2022
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