77 results on '"Snygg-Martin U"'
Number of results to display per page
Search Results
2. Risk predictors and outcomes of infective endocarditis among adult patients with congenital heart disease
- Author
-
Fedchenko, M, primary, Giang, K W, additional, Snygg-Martin, U, additional, Dellborg, M, additional, and Mandalenakis, Z, additional
- Published
- 2022
- Full Text
- View/download PDF
3. European Heart Rhythm Association (EHRA) international consensus document on how to prevent, diagnose, and treat cardiac implantable electronic device infections-endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS), International Society for Cardiovascular Infectious Diseases (ISCVID), and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)
- Author
-
Blomstrom-Lundqvist, C, Traykov, V, Erba, P, Burri, H, Nielsen, J, Bongiorni, M, Poole, J, Boriani, G, Costa, R, Deharo, J, Epstein, L, Saghy, L, Snygg-Martin, U, Starck, C, Tascini, C, Strathmore, N, Blomstrom-Lundqvist C., Traykov V., Erba P. A., Burri H., Nielsen J. C., Bongiorni M. G., Poole J., Boriani G., Costa R., Deharo J. -C., Epstein L. M., Saghy L., Snygg-Martin U., Starck C., Tascini C., Strathmore N., Blomstrom-Lundqvist, C, Traykov, V, Erba, P, Burri, H, Nielsen, J, Bongiorni, M, Poole, J, Boriani, G, Costa, R, Deharo, J, Epstein, L, Saghy, L, Snygg-Martin, U, Starck, C, Tascini, C, Strathmore, N, Blomstrom-Lundqvist C., Traykov V., Erba P. A., Burri H., Nielsen J. C., Bongiorni M. G., Poole J., Boriani G., Costa R., Deharo J. -C., Epstein L. M., Saghy L., Snygg-Martin U., Starck C., Tascini C., and Strathmore N.
- Abstract
Pacemakers, implantable cardiac defibrillators, and cardiac resynchronization therapy devices are potentially lifesaving treatments for a number of cardiac conditions but are not without risk. Most concerning is the risk of a cardiac implantable electronic device (CIED) infection, which is associated with significant morbidity, increased hospitalizations, reduced survival, and increased health care costs. Recommended preventive strategies such as administration of intravenous antibiotics before implantation are well-recognized. Uncertainties have remained about the role of various preventive, diagnostic, and treatment measures such as skin antiseptics, pocket antibiotic solutions, antibacterial envelopes, prolonged antibiotics post-implantation, and others. When compared with previous guidelines or consensus statements, the present consensus document gives guidance on the use of novel device alternatives, novel oral anticoagulants, antibacterial envelopes, prolonged antibiotics post-implantation, as well as definitions on minimum quality requirements for centres and operators and volumes. The recognition that an international consensus document focused on management of CIED infections is lacking, the dissemination of results from new important randomized trials focusing on prevention of CIED infections, and observed divergences in managing device-related infections as found in an European Heart Rhythm Association worldwide survey, provided a strong incentive for a Novel 2019 International State-of-the-art Consensus document on risk assessment, prevention, diagnosis, and treatment of CIED infections.
- Published
- 2020
4. European Heart Rhythm Association (EHRA) international consensus document on how to prevent, diagnose, and treat cardiac implantable electronic device infections—endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS), International Society for Cardiovascular Infectious Diseases (ISCVID) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)
- Author
-
Blomstrom-Lundqvist, C., Traykov, V., Erba, P. A., Burri, H., Nielsen, J. C., Bongiorni, M. G., Poole, J., Boriani, G., Costa, R., Deharo, J. -C., Epstein, L. M., Saghy, L., Snygg-Martin, U., Starck, C., Tascini, C., Strathmore, N., Kalarus, Z., Boveda, S., Dagres, N., Rinaldi, C. A., Biffi, M., Geller, L., Sokal, A., Birgersdotter-Green, U., Lever, N., Tajstra, M., Kutarski, A., Rodriguez, D. A., Hasse, B., Zinkernagel, A., Mangoni, E., Uppsala Universitet [Uppsala], Tokuda Hospital Sofia, University of Pisa - Università di Pisa, University Medical Center Groningen [Groningen] (UMCG), Aarhus University Hospital, Biorobotics Lab (University of Washington), University of Washington [Seattle], Università degli Studi di Modena e Reggio Emilia, Universidade Paulista [São Paulo] (UNIP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département de Cardiologie [Hôpital de la Timone - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE)-Assistance Publique - Hôpitaux de Marseille (APHM), Hofstra University [Hempstead], University of Szeged [Szeged], Department of Image Processing and Computer Graphics [Univ Szeged], University of Gothenburg (GU), West German Heart Center, Universität Duisburg-Essen [Essen], University Parthenope of Naples, The Royal Melbourne Hospital, Clinical sciences, Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Università degli Studi di Napoli 'Parthenope' = University of Naples (PARTHENOPE), Blomstrom-Lundqvist, C, Traykov, V, Erba, P, Burri, H, Nielsen, J, Bongiorni, M, Poole, J, Boriani, G, Costa, R, Deharo, J, Epstein, L, Saghy, L, Snygg-Martin, U, Starck, C, Tascini, C, Strathmore, N, Kalarus, Z, Boveda, S, Dagres, N, Rinaldi, C, Biffi, M, Geller, L, Sokal, A, Birgersdotter-Green, U, Lever, N, Tajstra, M, Kutarski, A, Rodriguez, D, Hasse, B, Zinkernagel, A, and Mangoni, E
- Subjects
Leads ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,Extraction ,030204 cardiovascular system & hematology ,law.invention ,Defibrillator ,0302 clinical medicine ,Randomized controlled trial ,law ,Health care ,Cardiac and Cardiovascular Systems ,Endocarditi ,03.02. Klinikai orvostan ,030212 general & internal medicine ,Antibiotic prophylaxis ,Cardiac resynchronization therapy ,Device ,Pacemaker ,Infection ,Kardiologi ,Re-implantation ,Endocarditis ,Latin America/epidemiology ,Cardiac implantable electronic device ,TRANSVENOUS LEAD EXTRACTION ,Defibrillators, Implantable/adverse effects ,Thoracic Surgery ,General Medicine ,STAPHYLOCOCCUS-AUREUS BACTEREMIA ,F-18-FDG PET/CT ,Defibrillators, Implantable ,SINGLE-CENTER EXPERIENCE ,3. Good health ,Cardiac implantable electronic devices ,EHRA consensus document ,Implantable cardioverter-defibrillators ,Microbiology ,Pacemakers ,Cardiothoracic surgery ,Risk assessment ,Cardiology and Cardiovascular Medicine ,EHRA Position Paper ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Asia ,Consensus ,PERMANENT PACEMAKER IMPLANTATION ,CARDIOVERTER-DEFIBRILLATOR IMPLANTATION ,Infections ,Communicable Diseases ,Implantable cardioverter-defibrillator ,03 medical and health sciences ,LONG-TERM COMPLICATIONS ,ANTIBIOTIC-PROPHYLAXIS ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Infections/diagnosis ,Physiology (medical) ,medicine ,Humans ,Intensive care medicine ,SURGICAL-SITE ,business.industry ,Cardiac Resynchronization Therapy Devices ,Latin America ,Lead ,RISK-FACTORS ,Artificial cardiac pacemaker ,Surgery ,Electronics ,Implantable cardioverterdefibrillators ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Pacemakers, implantable cardiac defibrillators, and cardiac resynchronization therapy devices are potentially life-saving treatments for a number of cardiac conditions, but are not without risk. Most concerning is the risk of a cardiac implantable electronic device (CIED) infection, which is associated with significant morbidity, increased hospitalizations, reduced survival, and increased healthcare costs. Recommended preventive strategies such as administration of intravenous antibiotics before implantation are well recognized. Uncertainties have remained about the role of various preventive, diagnostic, and treatment measures such as skin antiseptics, pocket antibiotic solutions, anti-bacterial envelopes, prolonged antibiotics post-implantation, and others. Guidance on whether to use novel device alternatives expected to be less prone to infections and novel oral anticoagulants is also limited, as are definitions on minimum quality requirements for centres and operators and volumes. Moreover, an international consensus document on management of CIED infections is lacking. The recognition of these issues, the dissemination of results from important randomized trials focusing on prevention of CIED infections, and observed divergences in managing device-related infections as found in an European Heart Rhythm Association worldwide survey, provided a strong incentive for a 2019 International State-of-the-art Consensus document on risk assessment, prevention, diagnosis, and treatment of CIED infections. This article is simultaneously published also in Eur J Cardiothorac Surg. (https://doi.org/10.1093/ejcts/ezz296) and European Heart Journal (https://doi.org/10.1093/eurheartj/ehaa010). Minor differences in style may appear in each publication, but the article is substantially the same in each journal.
- Published
- 2019
5. Clinical practice and implementation of guidelines for the prevention, diagnosis and management of cardiac implantable electronic device infections: results of a worldwide survey under the auspices of the European Heart Rhythm Association
- Author
-
Traykov, V, Bongiorni, M, Boriani, G, Burri, H, Costa, R, Dagres, N, Deharo, J, Epstein, L, Erba, P, Snygg-Martin, U, Nielsen, J, Poole, J, Saghy, L, Starck, C, Strathmore, N, Blomstrom-Lundqvist, C, Traykov V., Bongiorni M. G., Boriani G., Burri H., Costa R., Dagres N., Deharo J. -C., Epstein L. M., Erba P. A., Snygg-Martin U., Nielsen J. C., Poole J. E., Saghy L., Starck C., Strathmore N., Blomstrom-Lundqvist C., Traykov, V, Bongiorni, M, Boriani, G, Burri, H, Costa, R, Dagres, N, Deharo, J, Epstein, L, Erba, P, Snygg-Martin, U, Nielsen, J, Poole, J, Saghy, L, Starck, C, Strathmore, N, Blomstrom-Lundqvist, C, Traykov V., Bongiorni M. G., Boriani G., Burri H., Costa R., Dagres N., Deharo J. -C., Epstein L. M., Erba P. A., Snygg-Martin U., Nielsen J. C., Poole J. E., Saghy L., Starck C., Strathmore N., and Blomstrom-Lundqvist C.
- Abstract
AIMS: Cardiac implantable electronic device (CIED) infection rates are increasing. Worldwide compliance and disparities to published guidelines for the prevention, diagnosis and management of these conditions are not well elucidated. The purpose of this survey, therefore, was to clarify these issues through an inquiry to arrhythmia-related associations and societies worldwide. METHODS AND RESULTS: A questionnaire comprising 15 questions related to CIED infections was distributed among members of seven arrhythmia societies worldwide. A total of 234 centres in 62 countries reported implantation rates of which 159 (68.0%) performed more than 200 device implantations per year and 14 (6.0%) performed fewer than 50 implantations per year. The reported rates of CIED infections for 2017 were ≤2% in 78.7% of the centres, while the infection rates exceeded 5% in 7.8% of the centres. Preventive measures for CIED infection differed from published recommendations and varied among different regions mainly in terms of pocket irrigation and administering post-operative antimicrobial therapy the use of which was reported by 39.9% and 44% of the respondents, respectively. Antibacterial envelopes were used by 37.7% of the respondents in selected circumstances. In terms of pocket infection management, 62% of the respondents applied complete system removal as an initial step. Diagnostic pocket needle aspiration and pocket surgical debridement were reported by 15.8% and 11.8% of centres, respectively. CONCLUSION: Clinical practices for prevention and management of CIED do not fully comply with current recommendations and demonstrate considerable regional disparities. Further education and programmes for improved implementation of guidelines are mandatory.
- Published
- 2019
6. Warfarin therapy and incidence of cerebrovascular complications in left-sided native valve endocarditis
- Author
-
Snygg-Martin, U., Rasmussen, R. V., Hassager, C., Bruun, N. E., Andersson, R., and Olaison, L.
- Published
- 2011
- Full Text
- View/download PDF
7. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Association for Cardiothoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM)
- Author
-
Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoen B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestres C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., Walker D. M., Habib, G., Lancellotti, P., Antunes, M. J., Bongiorni, M. G., Casalta, J. -P., Del Zotti, F., Dulgheru, R., El Khoury, G., Erba, P. A., Iung, B., Miro, J. M., Mulder, B. J., Plonska-Gosciniak, E., Price, S., Roos-Hesselink, J., Snygg-Martin, U., Thuny, F., Mas, P. T., Vilacosta, I., Zamorano, J. L., Erol, C., Nihoyannopoulos, P., Aboyans, V., Agewall, S., Athanassopoulos, G., Aytekin, S., Benzer, W., Bueno, H., Broekhuizen, L., Carerj, S., Cosyns, B., De Backer, J., De Bonis, M., Dimopoulos, K., Donal, E., Drexel, H., Flachskampf, F. A., Hall, R., Halvorsen, S., Hoen, B., Kirchhof, P., Lainscak, M., Leite-Moreira, A. F., Lip, G. Y. H., Mestres, C. A., Piepoli, M. F., Punjabi, P. P., Rapezzi, C., Rosenhek, R., Siebens, K., Tamargo, J., Walker, D. M., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestres, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, and Walker, D
- Subjects
Algorithm ,Heart Valve Disease ,Decision Tree ,Decision Trees ,Heart Valve Diseases ,Humans ,Endocarditis, Bacterial ,Prognosis ,Algorithms ,Human - Published
- 2016
8. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Association for Cardiothoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM) [Linee guida ESC 2015 per il trattamento dell'endocardite infettiva: Task Force per il Trattamento dell'Endocardite Infettiva della Società Europea di Cardiologia (ESC): Con il patrocinio dell'Associazione Europea di Chirurgia Cardiotoracica (EACTS) e dell'Associazione Europea di Medicina Nucleare (EANM)]
- Author
-
Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestres, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoen B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestres C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., Walker D. M., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestres, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoen B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestres C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., and Walker D. M.
- Published
- 2016
9. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM)
- Author
-
Habib, G, Lancellotti, P, Antunes, Mj, Bongiorni, Mg, Casalta, Jp, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, Pa, Iung, B, Miro, Jm, Mulder, Bj, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Tornos Mas, P, Vilacosta, I, Zamorano, Jl, Document, Reviewers., Erol, Ç, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, Fa, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite-Moreira, Af, Lip, Gy, Mestres, Ca, Piepoli, Mf, Punjabi, Pp, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, Dm, Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, Zamorano JL, Document Reviewers., Erol Ç, Nihoyannopoulos P, Aboyans V, Agewall S, Athanassopoulos G, Aytekin S, Benzer W, Bueno H, Broekhuizen L, Carerj S, Cosyns B, De Backer J, De Bonis M, Dimopoulos K, Donal E, Drexel H, Flachskampf FA, Hall R, Halvorsen S, Hoen B, Kirchhof P, Lainscak M, Leite-Moreira AF, Lip GY, Mestres CA, Piepoli MF, Punjabi PP, Rapezzi C, Rosenhek R, Siebens K, Tamargo J, Walker DM, DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Habib, G, Lancellotti, P, Antunes, Mj, Bongiorni, Mg, Casalta, Jp, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, Pa, Iung, B, Miro, Jm, Mulder, Bj, Plonska gosciniak, E, Price, S, Roos hesselink, J, Snygg martin, U, Thuny, F, Mas, Pt, Vilacosta, I, Zamorano, Jl, Erol, Ç, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, DE BONIS, Michele, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, Fa, Hall, R, Halvorsen, S, Hoen, B, Kirchhof, P, Lainscak, M, Leite moreira, Af, Lip, Gy, Mestres, Ca, Piepoli, Mf, Punjabi, Pp, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, and Walker, Dm
- Subjects
Microbiological Techniques ,Heart disease ,Embolism ,Heart Valve Diseases ,Cardiac device ,Cardiac imaging ,Cardiac surgery ,Congenital heart disease ,Echocardiography ,Endocarditis ,Guidelines ,Infection ,Nuclear imaging ,Pregnancy ,Prevention ,Prognosis ,Prophylaxis ,Prosthetic heart valves ,Valve disease ,Guideline ,Arrhythmias ,Cardiovascular ,Congenital ,Postoperative Complications ,Recurrence ,Risk Factors ,Neoplasms ,Ambulatory Care ,Non-Infective ,Pericarditis ,Endocarditi ,Musculoskeletal Diseases ,Prophylaxi ,Heart Defects ,Cross Infection ,Acute Kidney Injury ,Operative ,Anti-Bacterial Agents ,Myocarditis ,Prosthetic heart valve ,Endocarditis, Non-Infective ,Infective endocarditis ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Infected ,Cardiac ,Heart Defects, Congenital ,Diagnostic Imaging ,medicine.medical_specialty ,Prosthesis-Related Infections ,Critical Care ,Prognosi ,Pregnancy Complications, Cardiovascular ,Risk Assessment ,NO ,Aneurysm, Infected ,Antibiotic Prophylaxis ,Arrhythmias, Cardiac ,Clinical Laboratory Techniques ,Dentistry, Operative ,Fibrinolytic Agents ,Heart Failure ,Humans ,Long-Term Care ,Nervous System Diseases ,Patient Care Team ,Splenic Diseases ,Thoracic Surgical Procedures ,Internal medicine ,medicine ,business.industry ,medicine.disease ,Aneurysm ,Pregnancy Complications ,Heart failure ,Dentistry ,business ,Fibrinolytic agent - Abstract
none 53 si The disclosure forms of all experts involved in the development of these guidelines are available on the ESC website http://www.escardio.org/guidelines. Representing the European Association of Nuclear Medicine (EANM); Representing the European Society of Clinical Microbiology and Infectious Diseases (ESCMID); and Representing the European Association for Cardio-Thoracic Surgery (EACTS). Guidelines for the management of infective endocarditis Habib G; Lancellotti P; Antunes MJ; Bongiorni MG; Casalta JP; Del Zotti F; Dulgheru R; El Khoury G; Erba PA; Iung B; Miro JM; Mulder BJ; Plonska-Gosciniak E; Price S; Roos-Hesselink J; Snygg-Martin U; Thuny F; Tornos Mas P; Vilacosta I; Zamorano JL; Document Reviewers.; Erol Ç; Nihoyannopoulos P; Aboyans V; Agewall S; Athanassopoulos G; Aytekin S; Benzer W; Bueno H; Broekhuizen L; Carerj S; Cosyns B; De Backer J; De Bonis M; Dimopoulos K; Donal E; Drexel H; Flachskampf FA; Hall R; Halvorsen S; Hoen B; Kirchhof P; Lainscak M; Leite-Moreira AF; Lip GY; Mestres CA; Piepoli MF; Punjabi PP; Rapezzi C; Rosenhek R; Siebens K; Tamargo J; Walker DM Habib G; Lancellotti P; Antunes MJ; Bongiorni MG; Casalta JP; Del Zotti F; Dulgheru R; El Khoury G; Erba PA; Iung B; Miro JM; Mulder BJ; Plonska-Gosciniak E; Price S; Roos-Hesselink J; Snygg-Martin U; Thuny F; Tornos Mas P; Vilacosta I; Zamorano JL; Document Reviewers.; Erol Ç; Nihoyannopoulos P; Aboyans V; Agewall S; Athanassopoulos G; Aytekin S; Benzer W; Bueno H; Broekhuizen L; Carerj S; Cosyns B; De Backer J; De Bonis M; Dimopoulos K; Donal E; Drexel H; Flachskampf FA; Hall R; Halvorsen S; Hoen B; Kirchhof P; Lainscak M; Leite-Moreira AF; Lip GY; Mestres CA; Piepoli MF; Punjabi PP; Rapezzi C; Rosenhek R; Siebens K; Tamargo J; Walker DM
- Published
- 2015
10. Wytyczne ESC dotyczaçe leczenia infekcyjnego zapalenia wsierdzia w 2015 roku
- Author
-
Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., and Zamorano J. L.
- Published
- 2015
11. 2015 ESC Guidelines for the management of infective endocarditis
- Author
-
Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Mirob, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoenb, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestresc, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Mirob J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoenb B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestresc C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., Walker D. M., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Mirob, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoenb, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestresc, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Mirob J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Erol C., Nihoyannopoulos P., Aboyans V., Agewall S., Athanassopoulos G., Aytekin S., Benzer W., Bueno H., Broekhuizen L., Carerj S., Cosyns B., De Backer J., De Bonis M., Dimopoulos K., Donal E., Drexel H., Flachskampf F. A., Hall R., Halvorsen S., Hoenb B., Kirchhof P., Lainscak M., Leite-Moreira A. F., Lip G. Y. H., Mestresc C. A., Piepoli M. F., Punjabi P. P., Rapezzi C., Rosenhek R., Siebens K., Tamargo J., and Walker D. M.
- Published
- 2015
12. Wytyczne ESC dotyczaçe leczenia infekcyjnego zapalenia wsierdzia w 2015 roku
- Author
-
Habib G., Lancellotti P., Antunes M. J., Bongiorni M. G., Casalta J. -P., Del Zotti F., Dulgheru R., El Khoury G., Erba P. A., Iung B., Miro J. M., Mulder B. J., Plonska-Gosciniak E., Price S., Roos-Hesselink J., Snygg-Martin U., Thuny F., Mas P. T., Vilacosta I., Zamorano J. L., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Miro, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, and Zamorano, J
- Subjects
IE, diagnosis - Published
- 2015
13. Impact of early valve surgery on outcome of staphylococcus aureus prosthetic valve infective endocarditis: Analysis in the international collaboration of endocarditis-prospective cohort study.
- Author
-
Vincelj J., Sexton D.J., Corey G.R., Chu V.H., Wang A., Erpelding M.-L., Durante-Mangoni E., Fernandez-Hidalgo N., Giannitsioti E., Hannan M.M., Lejko-Zupanc T., Pare C., Pericas J., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Bouza E., Fernandez M.A.G., Gonzalez-Ramallo V., Marin M., Pedromingo M., Roda J., Rodriguez-Creixems M., Solis J., Almirante B., Tornos P., De Alarcon A., Parra R., Alestig E., Johansson M., Olaison L., Snygg-Martin U., Pachirat O., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Bradley S., Kauffman C., Bedimo R., Crowley A.L., Douglas P., Drew L., Holland T., Lalani T., Mudrick D., Samad Z., Stryjewski M., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., Di Persio J., Salstrom S.-J., Baddley J., Patel M., Peterson G., Stancoven A., Afonso L., Kulman T., Levine D., Rybak M., Cabell C.H., Baloch K., Dixon C.C., Harding T., Jones-Richmond M., Pappas P., Park L.P., Redick T., Stafford J., Anstrom K., Bayer A.S., Karchmer A.W., Durack D.T., Eykyn S., Moreillon P., Chirouze C., Alla F., Fowler V.G., Miro J.M., Munoz P., Murdoch D.R., Tattevin P., Tribouilloy C., Hoen B., Clara L., Sanchez M., Nacinovich F., Oses P.F., Ronderos R., Sucari A., Thierer J., Casabe J., Cortes C., Altclas J., Kogan S., Spelman D., Athan E., Harris O., Kennedy K., Tan R., Gordon D., Papanicolas L., Eisen D., Grigg L., Street A., Korman T., Kotsanas D., Dever R., Konecny P., Lawrence R., Rees D., Ryan S., Feneley M.P., Harkness J., Jones P., Post J., Reinbott P., Gattringer R., Wiesbauer F., Andrade A.R., De Brito A.C.P., Guimaraes A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., De Medeiros Tranchesi R.A., Paiva M.G., Fortes C.Q., De Oliveira Ramos A., Ferraiuoli G., Golebiovski W., Lamas C., Santos M., Weksler C., Karlowsky J.A., Keynan Y., Morris A.M., Rubinstein E., Jones S.B., Garcia P., Cereceda M., Fica A., Mella R.M., Barsic B., Bukovski S., Krajinovic V., Pangercic A., Rudez I., Freiberger T., Pol J., Zaloudikova B., Zainab A., El Kholy A., Mishaal M., Rizk H., Aissa N., Alauzet C., Campagnac C., Doco-Lecompte T., Selton-Suty C., Casalta J.-P., Fournier P.-E., Habib G., Raoult D., Thuny F., Delahaye F., Delahaye A., Vandenesch F., Donal E., Donnio P.Y., Michelet C., Revest M., Violette J., Chevalier F., Jeu A., Rusinaru D.M.D., Sorel C., Bernard Y., Leroy J., Plesiat P., Naber C., Neuerburg C., Mazaheri B., Athanasia S., Deliolanis I., Giamarellou H., Tsaganos T., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Sharma G., Francis J., Nair L., Thomas V., Venugopal K., Hurley J., Gilon D., Israel S., Korem M., Strahilevitz J., Casillo R., Cuccurullo S., Dialetto G., Irene M., Ragone E., Tripodi M.F., Utili R., Cecchi E., De Rosa F., Forno D., Imazio M., Trinchero R., Tebini A., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Carosi G., Magri S., Signorini L., Baban T., Kanafani Z., Kanj S.S., Yasmine M., Abidin I., Tamin S.S., Martinez E.R., Nieto G.I.S., Van Der Meer J.T.M., Chambers S., Holland D., Morris A., Raymond N., Read K., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., Chipigina N., Kirill O., Vadim K., Vinogradova T., Edathodu J., Halim M., Lum L.-N., Tan R.-S., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castaneda X., Cervera C., Del Rio A., Falces C., Garcia-De-La-Maria C., Fita G., Gatell J.M., Marco F., Mestres C.A., Moreno A., Ninot S., Vincelj J., Sexton D.J., Corey G.R., Chu V.H., Wang A., Erpelding M.-L., Durante-Mangoni E., Fernandez-Hidalgo N., Giannitsioti E., Hannan M.M., Lejko-Zupanc T., Pare C., Pericas J., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Bouza E., Fernandez M.A.G., Gonzalez-Ramallo V., Marin M., Pedromingo M., Roda J., Rodriguez-Creixems M., Solis J., Almirante B., Tornos P., De Alarcon A., Parra R., Alestig E., Johansson M., Olaison L., Snygg-Martin U., Pachirat O., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Bradley S., Kauffman C., Bedimo R., Crowley A.L., Douglas P., Drew L., Holland T., Lalani T., Mudrick D., Samad Z., Stryjewski M., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., Di Persio J., Salstrom S.-J., Baddley J., Patel M., Peterson G., Stancoven A., Afonso L., Kulman T., Levine D., Rybak M., Cabell C.H., Baloch K., Dixon C.C., Harding T., Jones-Richmond M., Pappas P., Park L.P., Redick T., Stafford J., Anstrom K., Bayer A.S., Karchmer A.W., Durack D.T., Eykyn S., Moreillon P., Chirouze C., Alla F., Fowler V.G., Miro J.M., Munoz P., Murdoch D.R., Tattevin P., Tribouilloy C., Hoen B., Clara L., Sanchez M., Nacinovich F., Oses P.F., Ronderos R., Sucari A., Thierer J., Casabe J., Cortes C., Altclas J., Kogan S., Spelman D., Athan E., Harris O., Kennedy K., Tan R., Gordon D., Papanicolas L., Eisen D., Grigg L., Street A., Korman T., Kotsanas D., Dever R., Konecny P., Lawrence R., Rees D., Ryan S., Feneley M.P., Harkness J., Jones P., Post J., Reinbott P., Gattringer R., Wiesbauer F., Andrade A.R., De Brito A.C.P., Guimaraes A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., De Medeiros Tranchesi R.A., Paiva M.G., Fortes C.Q., De Oliveira Ramos A., Ferraiuoli G., Golebiovski W., Lamas C., Santos M., Weksler C., Karlowsky J.A., Keynan Y., Morris A.M., Rubinstein E., Jones S.B., Garcia P., Cereceda M., Fica A., Mella R.M., Barsic B., Bukovski S., Krajinovic V., Pangercic A., Rudez I., Freiberger T., Pol J., Zaloudikova B., Zainab A., El Kholy A., Mishaal M., Rizk H., Aissa N., Alauzet C., Campagnac C., Doco-Lecompte T., Selton-Suty C., Casalta J.-P., Fournier P.-E., Habib G., Raoult D., Thuny F., Delahaye F., Delahaye A., Vandenesch F., Donal E., Donnio P.Y., Michelet C., Revest M., Violette J., Chevalier F., Jeu A., Rusinaru D.M.D., Sorel C., Bernard Y., Leroy J., Plesiat P., Naber C., Neuerburg C., Mazaheri B., Athanasia S., Deliolanis I., Giamarellou H., Tsaganos T., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Sharma G., Francis J., Nair L., Thomas V., Venugopal K., Hurley J., Gilon D., Israel S., Korem M., Strahilevitz J., Casillo R., Cuccurullo S., Dialetto G., Irene M., Ragone E., Tripodi M.F., Utili R., Cecchi E., De Rosa F., Forno D., Imazio M., Trinchero R., Tebini A., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Carosi G., Magri S., Signorini L., Baban T., Kanafani Z., Kanj S.S., Yasmine M., Abidin I., Tamin S.S., Martinez E.R., Nieto G.I.S., Van Der Meer J.T.M., Chambers S., Holland D., Morris A., Raymond N., Read K., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., Chipigina N., Kirill O., Vadim K., Vinogradova T., Edathodu J., Halim M., Lum L.-N., Tan R.-S., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castaneda X., Cervera C., Del Rio A., Falces C., Garcia-De-La-Maria C., Fita G., Gatell J.M., Marco F., Mestres C.A., Moreno A., and Ninot S.
- Abstract
Background. The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis-Prospective Cohort Study. Methods. Participants were enrolled between June 2000 and December 2006. Cox proportional hazards modeling that included surgery as a time-dependent covariate and propensity adjustment for likelihood to receive cardiac surgery was used to evaluate the impact of EVS and 1-year all-cause mortality on patients with definite left-sided S. aureus PVIE and no history of injection drug use. Results. EVS was performed in 74 of the 168 (44.3%) patients. One-year mortality was significantly higher among patients with S. aureus PVIE than in patients with non-S. aureus PVIE (48.2% vs 32.9%; P = .003). Staphylococcus aureus PVIE patients who underwent EVS had a significantly lower 1-year mortality rate (33.8% vs 59.1%; P = .001). In multivariate, propensity-adjusted models, EVS was not associated with 1-year mortality (risk ratio, 0.67 [95% confidence interval, .39-1.15]; P = .15). Conclusions. In this prospective, multinational cohort of patients with S. aureus PVIE, EVS was not associated with reduced 1-year mortality. The decision to pursue EVS should be individualized for each patient, based upon infection-specific characteristics rather than solely upon the microbiology of the infection causing PVIE.Copyright © The Author 2014.
- Published
- 2015
14. Candida infective endocarditis: An observational cohort study with a focus on therapy.
- Author
-
Campagnac C., Llopis J., Marco F., Mestres C.A., Moreno A., Ninot S., Pare C., Pericas J.M., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Bouza E., Leoni M.E.G., Robles J.A.G., Ramallo V.G., Cruz A.F., Kestler M., Marin M., Selles M.M., Abella H.R., Roda J.R., Lopez R.A., Pinilla B., Pinto A., Valerio M., Vazquez P., Verde E., Almirante B., De Alarcon A., Parra R., Alestig E., Johansson M., Olaison L., Snygg-Martin U., Pachirat O., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Kauffman C., Bedimo R., Corey G.R., Crowley A.L., Douglas P., Drew L., Fowler V.G., Holland T., Lalani T., Mudrick D., Samad Z., Sexton D., Stryjewski M., Wang A., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., DiPersio J., Salstrom S.-J., Baddley J., Patel M., Peterson G., Stancoven A., Levine D., Riddle J., Rybak M., Cabell C.H., Baloch K., Dixon C.C., Harding T., Jones-Richmond M., Park L.P., Sanderford B., Stafford J., Anstrom K., Karchmer A.W., Sexton D.J., Durack D.T., Eykyn S., Moreillon P., Sexton. D.J., Arnold C.J., Johnson M., Bayer A.S., Bradley S., Giannitsioti E., Miro J.M., Tornos P., Tattevin P., Strahilevitz J., Spelman D., Athan E., Nacinovich F., Lamas C., Barsic B., Fernandez-Hidalgo N., Munoz P., Chu V.H., Clara L., Sanchez M., Casabe J., Cortes C., Oses P.F., Ronderos R., Sucari A., Thierer J., Altclas J., Kogan S., Harris O., Kennedy K., Tan R., Gordon D., Papanicolas L., Korman T., Kotsanas D., Dever R., Jones P., Konecny P., Lawrence R., Rees D., Ryan S., Feneley M.P., Harkness J., Post J., Reinbott P., Gattringer R., Wiesbauer F., Andrade A.R., De Brito A.C.P., Guimaraes A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., De Medeiros Tranchesi R.A., Paiva M.G., Fortes C.Q., De Oliveira Ramos A., Weksler C., Ferraiuoli G., Golebiovski W., Karlowsky J.A., Keynan Y., Morris A.M., Rubinstein E., Jones S.B., Garcia P., Cereceda M., Fica A., Mella R.M., Fernandez R., Franco L., Gonzalez J., Jaramillo A.N., Bukovski S., Krajinovic V., Pangercic A., Rudez I., Vincelj J., Freiberger T., Pol J., Zaloudikova B., Ashour Z., Kholy A.E., Mishaal M., Osama D., Rizk H., Aissa N., Alauzet C., Alla F., Doco-Lecompte T., Selton-Suty C., Casalta J.-P., Fournier P.-E., Habib G., Raoult D., Thuny F., Delahaye F., Delahaye A., Vandenesch F., Donal E., Donnio P.Y., Flecher E., Michelet C., Revest M., Chevalier F., Jeu A., Remadi J.P., Rusinaru D., Tribouilloy C., Bernard Y., Chirouze C., Hoen B., Leroy J., Plesiat P., Naber C., Neuerburg C., Mazaheri B., Helen G., Sofia A., Ioannis D., Thomas T., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Sharma G., Francis J., Nair L., Thomas V., Venugopal K., Hannan M.M., Hurley J.P., Cahan A., Gilon D., Israel S., Korem M., Durante-Mangoni E., Mattucci I., Pinto D., Agrusta F., Senese A., Ragone E., Utili R., Cecchi E., De Rosa F., Forno D., Imazio M., Trinchero R., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Carosi G., Magri S., Signorini L., Kanafani Z., Kanj S.S., Sharif-Yakan A., Abidin I., Tamin S.S., Martinez E.R., Nieto G.I.S., Van Der Meer J.T.M., Chambers S., Holland D., Morris A., Raymond N., Read K., Murdoch D.R., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., Chipigina N., Kirill O., Vadim K., Vinogradova T., Edathodu J., Halim M., Liew Y.-Y., Tan R.-S., Lejko-Zupanc T., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castaneda X., Cervera C., Falces C., Garcia-De-La-Maria C., Fita G., Gatell J.M., Heras M., Campagnac C., Llopis J., Marco F., Mestres C.A., Moreno A., Ninot S., Pare C., Pericas J.M., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Bouza E., Leoni M.E.G., Robles J.A.G., Ramallo V.G., Cruz A.F., Kestler M., Marin M., Selles M.M., Abella H.R., Roda J.R., Lopez R.A., Pinilla B., Pinto A., Valerio M., Vazquez P., Verde E., Almirante B., De Alarcon A., Parra R., Alestig E., Johansson M., Olaison L., Snygg-Martin U., Pachirat O., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Kauffman C., Bedimo R., Corey G.R., Crowley A.L., Douglas P., Drew L., Fowler V.G., Holland T., Lalani T., Mudrick D., Samad Z., Sexton D., Stryjewski M., Wang A., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., DiPersio J., Salstrom S.-J., Baddley J., Patel M., Peterson G., Stancoven A., Levine D., Riddle J., Rybak M., Cabell C.H., Baloch K., Dixon C.C., Harding T., Jones-Richmond M., Park L.P., Sanderford B., Stafford J., Anstrom K., Karchmer A.W., Sexton D.J., Durack D.T., Eykyn S., Moreillon P., Sexton. D.J., Arnold C.J., Johnson M., Bayer A.S., Bradley S., Giannitsioti E., Miro J.M., Tornos P., Tattevin P., Strahilevitz J., Spelman D., Athan E., Nacinovich F., Lamas C., Barsic B., Fernandez-Hidalgo N., Munoz P., Chu V.H., Clara L., Sanchez M., Casabe J., Cortes C., Oses P.F., Ronderos R., Sucari A., Thierer J., Altclas J., Kogan S., Harris O., Kennedy K., Tan R., Gordon D., Papanicolas L., Korman T., Kotsanas D., Dever R., Jones P., Konecny P., Lawrence R., Rees D., Ryan S., Feneley M.P., Harkness J., Post J., Reinbott P., Gattringer R., Wiesbauer F., Andrade A.R., De Brito A.C.P., Guimaraes A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., De Medeiros Tranchesi R.A., Paiva M.G., Fortes C.Q., De Oliveira Ramos A., Weksler C., Ferraiuoli G., Golebiovski W., Karlowsky J.A., Keynan Y., Morris A.M., Rubinstein E., Jones S.B., Garcia P., Cereceda M., Fica A., Mella R.M., Fernandez R., Franco L., Gonzalez J., Jaramillo A.N., Bukovski S., Krajinovic V., Pangercic A., Rudez I., Vincelj J., Freiberger T., Pol J., Zaloudikova B., Ashour Z., Kholy A.E., Mishaal M., Osama D., Rizk H., Aissa N., Alauzet C., Alla F., Doco-Lecompte T., Selton-Suty C., Casalta J.-P., Fournier P.-E., Habib G., Raoult D., Thuny F., Delahaye F., Delahaye A., Vandenesch F., Donal E., Donnio P.Y., Flecher E., Michelet C., Revest M., Chevalier F., Jeu A., Remadi J.P., Rusinaru D., Tribouilloy C., Bernard Y., Chirouze C., Hoen B., Leroy J., Plesiat P., Naber C., Neuerburg C., Mazaheri B., Helen G., Sofia A., Ioannis D., Thomas T., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Sharma G., Francis J., Nair L., Thomas V., Venugopal K., Hannan M.M., Hurley J.P., Cahan A., Gilon D., Israel S., Korem M., Durante-Mangoni E., Mattucci I., Pinto D., Agrusta F., Senese A., Ragone E., Utili R., Cecchi E., De Rosa F., Forno D., Imazio M., Trinchero R., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Carosi G., Magri S., Signorini L., Kanafani Z., Kanj S.S., Sharif-Yakan A., Abidin I., Tamin S.S., Martinez E.R., Nieto G.I.S., Van Der Meer J.T.M., Chambers S., Holland D., Morris A., Raymond N., Read K., Murdoch D.R., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., Chipigina N., Kirill O., Vadim K., Vinogradova T., Edathodu J., Halim M., Liew Y.-Y., Tan R.-S., Lejko-Zupanc T., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castaneda X., Cervera C., Falces C., Garcia-De-La-Maria C., Fita G., Gatell J.M., and Heras M.
- Abstract
Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and use of different antifungal treatment regimens for Candida infective endocarditis. This prospective cohort study was based on 70 cases of Candida infective endocarditis from the International Collaboration on Endocarditis (ICE)-Prospective Cohort Study and ICE-Plus databases collected between 2000 and 2010. The majority of infections were acquired nosocomially (67%). Congestive heart failure (24%), prosthetic heart valve (46%), and previous infective endocarditis (26%) were common comorbidities. Overall mortality was high, with 36% mortality in the hospital and 59% at 1 year. On univariate analysis, older age, heart failure at baseline, persistent candidemia, nosocomial acquisition, heart failure as a complication, and intracardiac abscess were associated with higher mortality. Mortality was not affected by use of surgical therapy or choice of antifungal agent. A subgroup analysis was performed on 33 patients for whom specific antifungal therapy information was available. In this subgroup, 11 patients received amphotericin B-based therapy and 14 received echinocandin-based therapy. Despite a higher percentage of older patients and nosocomial infection in the echinocandin group, mortality rates were similar between the two groups. In conclusion, Candida infective endocarditis is associated with a high mortality rate that was not impacted by choice of antifungal therapy or by adjunctive surgical intervention. Additionally, echinocandin therapy was as effective as amphotericin B-based therapy in the small subgroup analysis.Copyright © 2015, American Society for Microbiology.
- Published
- 2015
15. One-year outcome following biological or mechanical valve replacement for infective endocarditis.
- Author
-
Pangercic A., Munoz P., Pedromingo M., Roda J., Rodriguez-Creixems M., Solis J., Almirante B., Fernandez-Hidalgo N., Tornos P., de Alarcon A., Parra R., Alestig E., Johansson M., Olaison L., Snygg-Martin U., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Bradley S., Kauffman C., Bedimo R., Corey G.R., Crowley A.L., Douglas P., Drew L., Fowler V.G., Holland T., Lalani T., Mudrick D., Samad Z., Sexton D.J., Stryjewski M., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., Dipersio J., Salstrom S.-J., Baddley J., Patel M., Peterson G., Stancoven A., Levine D., Riddle J., Rybak M., Cabell C.H., Baloch K., Dixon C.C., Harding T., Jones-Richmond M., Park L.P., Sanderford B., Stafford J., Anstrom K., Bayer A.S., Karchmer A.W., Durack D.T., Eykyn S., Moreillon P., Delahaye F., Chu V.H., Altclas J., Barsic B., Delahaye A., Freiberger T., Gordon D.L., Hannan M.M., Hoen B., Kanj S.S., Lejko-Zupanc T., Mestres C.A., Pachirat O., Pappas P., Lamas C., Selton-Suty C., Tan R., Tattevin P., Wang A., Clara L., Sanchez M., Casabe J., Cortes C., Nacinovich F., Oses P.F., Ronderos R., Sucari A., Thierer J., Kogan S., Spelman D., Athan E., Harris O., Kennedy K., Gordon D., Papanicolas L., Eisen D., Grigg L., Street A., Korman T., Kotsanas D., Dever R., Jones P., Konecny P., Lawrence R., Rees D., Ryan S., Feneley M.P., Harkness J., Post J., Reinbott P., Gattringer R., Wiesbauer F., Andrade A.R., de Brito A.C.P., Guimaraes A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., Tranchesi R.A.M., Paiva M.G., Fortes C.Q., Ramos A.O., Ferraiuoli G., Golebiovski W., Weksler C., Santos M., Karlowsky J.A., Keynan Y., Morris A.M., Rubinstein E., Jones S.B., Garcia P., Cereceda M., Fica A., Mella R.M., Fernandez R., Franco L., Gonzalez J., Jaramillo A.N., Bukovski S., Krajinovic V., Sharma G., Rudez I., Vincelj J., Pol J., Zaloudikova B., Ashour Z., El Kholy A., Mishaal M., Osama D., Rizk H., Aissa N., Alauzet C., Alla F., Campagnac C., Doco-Lecompte T., Goehringer F., Casalta J.-P., Fournier P.-E., Habib G., Raoult D., Thuny F., Vandenesch F., Donal E., Donnio P.Y., Flecher E., Michelet C., Revest M., Chevalier F., Jeu A., Remadi J.P., Rusinaru D., Tribouilloy C., Bernard Y., Chirouze C., Leroy J., Plesiat P., Naber C., Neuerburg C., Mazaheri B., Thomas T., Giannitsioti E., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Papanikolaou K., Francis J., Nair L., Thomas V., Venugopal K., Hannan M., Hurley J., Cahan A., Gilon D., Israel S., Korem M., Strahilevitz J., Durante-Mangoni E., Mattucci I., Pinto D., Agrusta F., Senese A., Ragone E., Utili R., Cecchi E., De Rosa F., Forno D., Imazio M., Trinchero R., Tebini A., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Carosi G., Magri S., Signorini L., Anouti K., Chahoud J., Kanafani Z., Abidin I., Tamin S.S., Martinez E.R., Nieto G.I.S., van der Meer J.T.M., Chambers S., Holland D., Morris A., Raymond N., Read K., Murdoch D.R., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., Chipigina N., Kirill O., Vadim K., Vinogradova T., Edathodu J., Halim M., Liew Y.-Y., Tan R.-S., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castaneda X., Cervera C., Del Rio A., Falces C., Garcia-De-la-maria C., Fita G., Gatell J.M., Heras M., Llopis J., Marco F., Miro J.M., Moreno A., Ninot S., Pare C., Pericas J.M., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Bouza E., Fernandez M.A.G., Gonzalez-Ramallo V., Marin M., Pangercic A., Munoz P., Pedromingo M., Roda J., Rodriguez-Creixems M., Solis J., Almirante B., Fernandez-Hidalgo N., Tornos P., de Alarcon A., Parra R., Alestig E., Johansson M., Olaison L., Snygg-Martin U., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Bradley S., Kauffman C., Bedimo R., Corey G.R., Crowley A.L., Douglas P., Drew L., Fowler V.G., Holland T., Lalani T., Mudrick D., Samad Z., Sexton D.J., Stryjewski M., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., Dipersio J., Salstrom S.-J., Baddley J., Patel M., Peterson G., Stancoven A., Levine D., Riddle J., Rybak M., Cabell C.H., Baloch K., Dixon C.C., Harding T., Jones-Richmond M., Park L.P., Sanderford B., Stafford J., Anstrom K., Bayer A.S., Karchmer A.W., Durack D.T., Eykyn S., Moreillon P., Delahaye F., Chu V.H., Altclas J., Barsic B., Delahaye A., Freiberger T., Gordon D.L., Hannan M.M., Hoen B., Kanj S.S., Lejko-Zupanc T., Mestres C.A., Pachirat O., Pappas P., Lamas C., Selton-Suty C., Tan R., Tattevin P., Wang A., Clara L., Sanchez M., Casabe J., Cortes C., Nacinovich F., Oses P.F., Ronderos R., Sucari A., Thierer J., Kogan S., Spelman D., Athan E., Harris O., Kennedy K., Gordon D., Papanicolas L., Eisen D., Grigg L., Street A., Korman T., Kotsanas D., Dever R., Jones P., Konecny P., Lawrence R., Rees D., Ryan S., Feneley M.P., Harkness J., Post J., Reinbott P., Gattringer R., Wiesbauer F., Andrade A.R., de Brito A.C.P., Guimaraes A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., Tranchesi R.A.M., Paiva M.G., Fortes C.Q., Ramos A.O., Ferraiuoli G., Golebiovski W., Weksler C., Santos M., Karlowsky J.A., Keynan Y., Morris A.M., Rubinstein E., Jones S.B., Garcia P., Cereceda M., Fica A., Mella R.M., Fernandez R., Franco L., Gonzalez J., Jaramillo A.N., Bukovski S., Krajinovic V., Sharma G., Rudez I., Vincelj J., Pol J., Zaloudikova B., Ashour Z., El Kholy A., Mishaal M., Osama D., Rizk H., Aissa N., Alauzet C., Alla F., Campagnac C., Doco-Lecompte T., Goehringer F., Casalta J.-P., Fournier P.-E., Habib G., Raoult D., Thuny F., Vandenesch F., Donal E., Donnio P.Y., Flecher E., Michelet C., Revest M., Chevalier F., Jeu A., Remadi J.P., Rusinaru D., Tribouilloy C., Bernard Y., Chirouze C., Leroy J., Plesiat P., Naber C., Neuerburg C., Mazaheri B., Thomas T., Giannitsioti E., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Papanikolaou K., Francis J., Nair L., Thomas V., Venugopal K., Hannan M., Hurley J., Cahan A., Gilon D., Israel S., Korem M., Strahilevitz J., Durante-Mangoni E., Mattucci I., Pinto D., Agrusta F., Senese A., Ragone E., Utili R., Cecchi E., De Rosa F., Forno D., Imazio M., Trinchero R., Tebini A., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Carosi G., Magri S., Signorini L., Anouti K., Chahoud J., Kanafani Z., Abidin I., Tamin S.S., Martinez E.R., Nieto G.I.S., van der Meer J.T.M., Chambers S., Holland D., Morris A., Raymond N., Read K., Murdoch D.R., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., Chipigina N., Kirill O., Vadim K., Vinogradova T., Edathodu J., Halim M., Liew Y.-Y., Tan R.-S., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castaneda X., Cervera C., Del Rio A., Falces C., Garcia-De-la-maria C., Fita G., Gatell J.M., Heras M., Llopis J., Marco F., Miro J.M., Moreno A., Ninot S., Pare C., Pericas J.M., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Bouza E., Fernandez M.A.G., Gonzalez-Ramallo V., and Marin M.
- Abstract
Methods and results Among 5591 patients included in the International Collaboration on Endocarditis Prospective Cohort Study, 1467 patients with definite IE were operated on during the active phase and had a biological (37%) or mechanical (63%) valve replacement. Patients who received bioprostheses were older (62 vs 54 years), more often had a history of cancer (9% vs 6%), and had moderate or severe renal disease (9% vs 4%); proportion of health care-associated IE was higher (26% vs 17%); intracardiac abscesses were more frequent (30% vs 23%). In-hospital and 1-year death rates were higher in the bioprosthesis group, 20.5% vs 14.0% (p = 0.0009) and 25.3% vs 16.6% (p <.0001), respectively. In multivariable analysis, mechanical prostheses were less commonly implanted in older patients (odds ratio: 0.64 for every 10 years), and in patients with a history of cancer (0.72), but were more commonly implanted in mitral position (1.60). Bioprosthesis was independently associated with 1-year mortality (hazard ratio: 1.298). Conclusions Patients with IE who receive a biological valve replacement have significant differences in clinical characteristics compared to patients who receive a mechanical prosthesis. Biological valve replacement is independently associated with a higher in-hospital and 1-year mortality, a result which is possibly related to patient characteristics rather than valve dysfunction. Background Nearly half of patients require cardiac surgery during the acute phase of infective endocarditis (IE). We describe the characteristics of patients according to the type of valve replacement (mechanical or biological), and examine whether the type of prosthesis was associated with in-hospital and 1-year mortality.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
- Published
- 2014
16. Nephrotoxicity during aminoglycoside therapy for infective endocarditis
- Author
-
Olaison, L.E.A., primary, Johansson, N., additional, Snygg-Martin, U., additional, and Sandberg, T., additional
- Published
- 2014
- Full Text
- View/download PDF
17. Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke.
- Author
-
Zaloudikova B., Garcia-De-La-Maria C., Fita G., Gatell J.M., Marco F., Mestres C.A., Miro J.M., Moreno A., Ninot S., Pare C., Pericas J., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Bouza E., Fernandez M.A.G., Gonzalez-Ramallo V., Marin M., Munoz P., Pedromingo M., Roda J., Rodriguez-Creixems M., Solis J., Almirante B., Fernandez-Hidalgo N., Tornos P., De Alarcon A., Parra R., Alestig E., Johansson M., Snygg-Martin U., Pachirat O., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Bradley S., Kauffman C., Bedimo R., Corey G.R., Crowley A.L., Douglas P., Drew L., Fowler V.G., Holland T., Lalani T., Mudrick D., Samad Z., Sexton D., Stryjewski M., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., Di Persio J., Salstrom S.-J., Baddley J., Peterson G., Stancoven A., Afonso L., Kulman T., Levine D., Rybak M., Cabell C.H., Morris A.M., Rubinstein E., Jones S.B., Garcia P., Barsic B., Dickerman S., Krajinovic V., Pappas P., Altclas J., Carosi G., Casabe J.H., Chu V.H., Delahaye F., Edathodu J., Fortes C.Q., Olaison L., Pangercic A., Patel M., Rudez I., Tamin S.S., Vincelj J., Bayer A.S., Wang A., Clara L., Sanchez M., Nacinovich F., Oses P.F., Ronderos R., Sucari A., Thierer J., Casabe J., Cortes C., Kogan S., Spelman D., Athan E., Harris O., Kennedy K., Tan R., Gordon D., Papanicolas L., Eisen D., Grigg L., Street A., Korman T., Kotsanas D., Dever R., Jones P., Konecny P., Lawrence R., Rees D., Ryan S., Feneley M.P., Harkness J., Post J., Reinbott P., Gattringer R., Wiesbauer F., Andrade A.R., De Brito A.C.P., Guimaraes A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., De Medeiros Tranchesi R.A., Paiva M.G., De Oliveira Ramos A., Ferraiuoli G., Golebiovski W., Lamas C., Santos M., Weksler C., Karlowsky J.A., Keynan Y., Cereceda M., Fica A., Mella R.M., Bukovski S., Freiberger T., Pol J., Sharma G., Ashour Z., Kholy A.E., Mishaal M., Rizk H., Aissa N., Alauzet C., Alla F., Campagnac C., Doco-Lecompte T., Selton-Suty C., Casalta J.-P., Fournier P.-E., Habib G., Raoult D., Thuny F., Delahaye A., Vandenesch F., Donal E., Donnio P.Y., Michelet C., Revest M., Tattevin P., Violette J., Chevalier F., Jeu A., Rusinaru D., Sorel C., Tribouilloy C., Bernard Y., Chirouze C., Hoen B., Leroy J., Plesiat P., Naber G.C., Neuerburg C., Mazaheri B., Naber C., Athanasia S., Giannitsioti E., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Francis J., Nair L., Thomas D.M.V., Venugopal K., Hannan M., Hurley J., Cahan A., Gilon D., Israel S., Korem M., Strahilevitz J., Tripodi M.F., Casillo R., Cuccurullo S., Dialetto G., Durante-Mangoni E., Irene M., Ragone E., Utili R., Cecchi E., Rosa F.D., Forno D., Imazio M., Trinchero R., Tebini A., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Magri S., Signorini L., Baban T., Kanafani Z., Kanj S.S., Sfeir J., Yasmine M., Abidin I., Martinez E.R., Nieto G.I.S., Van Der Meer J.T.M., Chambers S., Murdoch D.R., Holland D., Morris A., Raymond N., Read K., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., Chipigina N., Kirill O., Vadim K., Vinogradova T., Halim M., Lum L.-N., Tan R.-S., Lejko-Zupanc T., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castaneda X., Cervera C., Del Rio A., Falces C., Zaloudikova B., Garcia-De-La-Maria C., Fita G., Gatell J.M., Marco F., Mestres C.A., Miro J.M., Moreno A., Ninot S., Pare C., Pericas J., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Bouza E., Fernandez M.A.G., Gonzalez-Ramallo V., Marin M., Munoz P., Pedromingo M., Roda J., Rodriguez-Creixems M., Solis J., Almirante B., Fernandez-Hidalgo N., Tornos P., De Alarcon A., Parra R., Alestig E., Johansson M., Snygg-Martin U., Pachirat O., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Bradley S., Kauffman C., Bedimo R., Corey G.R., Crowley A.L., Douglas P., Drew L., Fowler V.G., Holland T., Lalani T., Mudrick D., Samad Z., Sexton D., Stryjewski M., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., Di Persio J., Salstrom S.-J., Baddley J., Peterson G., Stancoven A., Afonso L., Kulman T., Levine D., Rybak M., Cabell C.H., Morris A.M., Rubinstein E., Jones S.B., Garcia P., Barsic B., Dickerman S., Krajinovic V., Pappas P., Altclas J., Carosi G., Casabe J.H., Chu V.H., Delahaye F., Edathodu J., Fortes C.Q., Olaison L., Pangercic A., Patel M., Rudez I., Tamin S.S., Vincelj J., Bayer A.S., Wang A., Clara L., Sanchez M., Nacinovich F., Oses P.F., Ronderos R., Sucari A., Thierer J., Casabe J., Cortes C., Kogan S., Spelman D., Athan E., Harris O., Kennedy K., Tan R., Gordon D., Papanicolas L., Eisen D., Grigg L., Street A., Korman T., Kotsanas D., Dever R., Jones P., Konecny P., Lawrence R., Rees D., Ryan S., Feneley M.P., Harkness J., Post J., Reinbott P., Gattringer R., Wiesbauer F., Andrade A.R., De Brito A.C.P., Guimaraes A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., De Medeiros Tranchesi R.A., Paiva M.G., De Oliveira Ramos A., Ferraiuoli G., Golebiovski W., Lamas C., Santos M., Weksler C., Karlowsky J.A., Keynan Y., Cereceda M., Fica A., Mella R.M., Bukovski S., Freiberger T., Pol J., Sharma G., Ashour Z., Kholy A.E., Mishaal M., Rizk H., Aissa N., Alauzet C., Alla F., Campagnac C., Doco-Lecompte T., Selton-Suty C., Casalta J.-P., Fournier P.-E., Habib G., Raoult D., Thuny F., Delahaye A., Vandenesch F., Donal E., Donnio P.Y., Michelet C., Revest M., Tattevin P., Violette J., Chevalier F., Jeu A., Rusinaru D., Sorel C., Tribouilloy C., Bernard Y., Chirouze C., Hoen B., Leroy J., Plesiat P., Naber G.C., Neuerburg C., Mazaheri B., Naber C., Athanasia S., Giannitsioti E., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Francis J., Nair L., Thomas D.M.V., Venugopal K., Hannan M., Hurley J., Cahan A., Gilon D., Israel S., Korem M., Strahilevitz J., Tripodi M.F., Casillo R., Cuccurullo S., Dialetto G., Durante-Mangoni E., Irene M., Ragone E., Utili R., Cecchi E., Rosa F.D., Forno D., Imazio M., Trinchero R., Tebini A., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Magri S., Signorini L., Baban T., Kanafani Z., Kanj S.S., Sfeir J., Yasmine M., Abidin I., Martinez E.R., Nieto G.I.S., Van Der Meer J.T.M., Chambers S., Murdoch D.R., Holland D., Morris A., Raymond N., Read K., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., Chipigina N., Kirill O., Vadim K., Vinogradova T., Halim M., Lum L.-N., Tan R.-S., Lejko-Zupanc T., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castaneda X., Cervera C., Del Rio A., and Falces C.
- Abstract
Background. The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. Methods. Data were obtained from the International Collaboration on Endocarditis-Prospective Cohort Study of 4794 patients with definite IE who were admitted to 64 centers from June 2000 through December 2006. Multivariate logistic regression and Cox regression analyses were performed to estimate the impact of early surgery on hospital and 1-year mortality after adjustments for other significant covariates. Results. Of the 857 patients with IE complicated by ischemic stroke syndromes, 198 who underwent valve replacement surgery poststroke were available for analysis. Overall, 58 (29.3%) patients underwent early surgical treatment vs 140 (70.7%) patients who underwent late surgical treatment. After adjustment for other risk factors, early surgery was not significantly associated with increased in-hospital mortality rates (odds ratio, 2.308; 95% confidence interval[CI], .942-5.652). Overall, probability of death after 1-year follow-up did not differ between 2 treatment groups (27.1% in early surgery and 19.2% in late surgery group, P = .328; adjusted hazard ratio, 1.138; 95% CI, .802-1.650). Conclusions. There is no apparent survival benefit in delaying surgery when indicated in IE patients after ischemic stroke. Further observational analyses that include detailed pre- and postoperative clinical neurologic findings and advanced imaging data (eg, ischemic stroke size), may allow for more refined recommendations on the optimal timing of valvular surgery in patients with IE and recent stroke syndromes.Copyright © The Author 2012.
- Published
- 2013
18. HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort.
- Author
-
Revest M., Kirill O., Vadim K., Vinogradova T., Edathodu J., Halim M., Lum L.-N., Tan R.-S., Lejko-Zupanc T., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castan~eda X., Cervera C., Rio A., Falces C., Garcia-de-la-Maria C., Fita G., Gatell J.M., Marco F., Mestres C.A., Miro J.M., Moreno A., Ninot S., Pare C., Pericas J., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Fernandez M.A.G., Gonzalez-Ramallo V., Marin M., Mun~oz P., Pedromingo M., Roda J., Rodriguez-Creixems M., Solis J., Almirante B., Fernandez-Hidalgo N., Tornos P., de Alarcon A., Parra R., Alestig E., Johansson M., Snygg-Martin U., Pachirat O., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Bradley S., Kauffman C., Bedimo R., Crowley A.L., Douglas P., Drew L., Fowler V.G., Holland T., Lalani T., Mudrick D., Samad Z., Sexton D., Stryjewski M., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., DiPersio J., Salstrom S.-J., Baddley J., Patel M., Peterson G., Stancoven A., Afonso L., Kulman T., Levine D., Rybak M., Baloch K., Corey G.R., Dixon C.C., Fowler Jr. V.G., Harding T., Jones-Richmond M., Pappas P., Park L.P., Redick T., Stafford J., Anstrom K., Chu V.H., Karchmer A.W., Murdoch D.R., Sexton D.J., Wang A., Bayer A.S., Cabell C.H., Chu V., Durack D.T., Eykyn S., Hoen B., Moreillon P., Olaison L., Raoult D., Rubinstein E., Chambers S.T., Murdoch D., Bouza E., Hannan M.M., Kanafani Z.A., Lang S., Clara L., Sanchez M., Nacinovich F., Oses P.F., Ronderos R., Sucari A., Thierer J., Casabe J., Cortes C., Altclas J., Silvia Kogan S., Spelman D., Athan E., Harris O., Kennedy K., Tan R., Gordon D., Papanicolas L., Eisen D., Grigg L., Street A., Korman T., Kotsanas D., Dever R., Konecny P., Lawrence R., Rees D., Feneley M.P., Harkness J., Jones P., Post J., Reinbott P., Ryan S., Gattringer R., Wiesbauer F., Andrade A.R., de Brito A.C.P., Guimara~es A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., de Medeiros Tranchesi R.A., Paiva M.G., Fortes C.Q., de Oliveira Ramos A., Ferraiuoli G., Golebiovski W., Lamas C., Santos M., Weksler C., Karlowsky J.A., Keynan Y., Morris A.M., Jones S.B., Garcia P., Cereceda M., Fica A., Mella R.M., Barsic B., Bukovski S., Krajinovic V., Pangercic A., Rudez I., Vincelj J., Freiberger T., Pol J., Zaloudikova B., Ashour Z., Kholy A.E., Mishaal M., Rizk H., Aissa N., Alauzet C., Alla F., Campagnac C., Doco-Lecompte T., Selton-Suty C., Casalta J.-P., Fournier P.-E., Habib G., Thuny F., Delahaye F., Delahaye A., Vandenesch F., Donal E., Donnio P.Y., Michelet C., Sharma G., Tattevin P., Violette J., Chevalier F., Jeu A., Rusinaru D.M.D., Sorel C., Tribouilloy C., Bernard Y., Chirouze C., Leroy J., Plesiat P., Naber C., Mazaheri B., Neuerburg C., Athanasia S., Giannitsioti E., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Francis J., Nair L., Thomas V., Venugopal K., Hannan M., Hurley J., Gilon D., Israel S., Korem M., Strahilevitz J., Tripodi M.F., Casillo R., Cuccurullo S., Dialetto G., Durante-Mangoni E., Irene M., Ragone E., Utili R., Cecchi E., De Rosa F., Forno D., Imazio M., Trinchero R., Tebini A., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Carosi G., Magri S., Signorini L., Baban T., Kanafani Z., Kanj S.S., Sfeir J., Yasmine M., Abidin I., Tamin S.S., Martinez E.R., Nieto G.I.S., van der Meer J.T.M., Chambers S., Holland D., Morris A., Raymond N., Read K., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., Chipigina N., Revest M., Kirill O., Vadim K., Vinogradova T., Edathodu J., Halim M., Lum L.-N., Tan R.-S., Lejko-Zupanc T., Logar M., Mueller-Premru M., Commerford P., Commerford A., Deetlefs E., Hansa C., Ntsekhe M., Almela M., Armero Y., Azqueta M., Castan~eda X., Cervera C., Rio A., Falces C., Garcia-de-la-Maria C., Fita G., Gatell J.M., Marco F., Mestres C.A., Miro J.M., Moreno A., Ninot S., Pare C., Pericas J., Ramirez J., Rovira I., Sitges M., Anguera I., Font B., Guma J.R., Bermejo J., Fernandez M.A.G., Gonzalez-Ramallo V., Marin M., Mun~oz P., Pedromingo M., Roda J., Rodriguez-Creixems M., Solis J., Almirante B., Fernandez-Hidalgo N., Tornos P., de Alarcon A., Parra R., Alestig E., Johansson M., Snygg-Martin U., Pachirat O., Pachirat P., Pussadhamma B., Senthong V., Casey A., Elliott T., Lambert P., Watkin R., Eyton C., Klein J.L., Bradley S., Kauffman C., Bedimo R., Crowley A.L., Douglas P., Drew L., Fowler V.G., Holland T., Lalani T., Mudrick D., Samad Z., Sexton D., Stryjewski M., Woods C.W., Lerakis S., Cantey R., Steed L., Wray D., Dickerman S.A., Bonilla H., DiPersio J., Salstrom S.-J., Baddley J., Patel M., Peterson G., Stancoven A., Afonso L., Kulman T., Levine D., Rybak M., Baloch K., Corey G.R., Dixon C.C., Fowler Jr. V.G., Harding T., Jones-Richmond M., Pappas P., Park L.P., Redick T., Stafford J., Anstrom K., Chu V.H., Karchmer A.W., Murdoch D.R., Sexton D.J., Wang A., Bayer A.S., Cabell C.H., Chu V., Durack D.T., Eykyn S., Hoen B., Moreillon P., Olaison L., Raoult D., Rubinstein E., Chambers S.T., Murdoch D., Bouza E., Hannan M.M., Kanafani Z.A., Lang S., Clara L., Sanchez M., Nacinovich F., Oses P.F., Ronderos R., Sucari A., Thierer J., Casabe J., Cortes C., Altclas J., Silvia Kogan S., Spelman D., Athan E., Harris O., Kennedy K., Tan R., Gordon D., Papanicolas L., Eisen D., Grigg L., Street A., Korman T., Kotsanas D., Dever R., Konecny P., Lawrence R., Rees D., Feneley M.P., Harkness J., Jones P., Post J., Reinbott P., Ryan S., Gattringer R., Wiesbauer F., Andrade A.R., de Brito A.C.P., Guimara~es A.C., Grinberg M., Mansur A.J., Siciliano R.F., Strabelli T.M.V., Vieira M.L.C., de Medeiros Tranchesi R.A., Paiva M.G., Fortes C.Q., de Oliveira Ramos A., Ferraiuoli G., Golebiovski W., Lamas C., Santos M., Weksler C., Karlowsky J.A., Keynan Y., Morris A.M., Jones S.B., Garcia P., Cereceda M., Fica A., Mella R.M., Barsic B., Bukovski S., Krajinovic V., Pangercic A., Rudez I., Vincelj J., Freiberger T., Pol J., Zaloudikova B., Ashour Z., Kholy A.E., Mishaal M., Rizk H., Aissa N., Alauzet C., Alla F., Campagnac C., Doco-Lecompte T., Selton-Suty C., Casalta J.-P., Fournier P.-E., Habib G., Thuny F., Delahaye F., Delahaye A., Vandenesch F., Donal E., Donnio P.Y., Michelet C., Sharma G., Tattevin P., Violette J., Chevalier F., Jeu A., Rusinaru D.M.D., Sorel C., Tribouilloy C., Bernard Y., Chirouze C., Leroy J., Plesiat P., Naber C., Mazaheri B., Neuerburg C., Athanasia S., Giannitsioti E., Mylona E., Paniara O., Papanicolaou K., Pyros J., Skoutelis A., Francis J., Nair L., Thomas V., Venugopal K., Hannan M., Hurley J., Gilon D., Israel S., Korem M., Strahilevitz J., Tripodi M.F., Casillo R., Cuccurullo S., Dialetto G., Durante-Mangoni E., Irene M., Ragone E., Utili R., Cecchi E., De Rosa F., Forno D., Imazio M., Trinchero R., Tebini A., Grossi P., Lattanzio M., Toniolo A., Goglio A., Raglio A., Ravasio V., Rizzi M., Suter F., Carosi G., Magri S., Signorini L., Baban T., Kanafani Z., Kanj S.S., Sfeir J., Yasmine M., Abidin I., Tamin S.S., Martinez E.R., Nieto G.I.S., van der Meer J.T.M., Chambers S., Holland D., Morris A., Raymond N., Read K., Dragulescu S., Ionac A., Mornos C., Butkevich O.M., and Chipigina N.
- Abstract
The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p<0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p<0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p<0.01) and younger age (OR 0.62; CI 0.49-0.90; p<0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p<0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences. © 2013 Chambers et al.
- Published
- 2013
19. HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort
- Author
-
Abbate, A, Chambers, ST, Murdoch, D, Morris, A, Holland, D, Pappas, P, Almela, M, Fernandez-Hidalgo, N, Almirante, B, Bouza, E, Forno, D, del Rio, A, Hannan, MM, Harkness, J, Kanafani, ZA, Lalani, T, Lang, S, Raymond, N, Read, K, Vinogradova, T, Woods, CW, Wray, D, Corey, GR, Chu, VH, Clara, L, Sanchez, M, Nacinovich, F, Fernandez Oses, P, Ronderos, R, Sucari, A, Thierer, J, Casabe, J, Cortes, C, Altclas, J, Kogan, S, Spelman, D, Athan, E, Harris, O, Kennedy, K, Tan, R, Gordon, D, Papanicolas, L, Eisen, D, Grigg, L, Street, A, Korman, T, Kotsanas, D, Dever, R, Jones, P, Konecny, P, Lawrence, R, Rees, D, Ryan, S, Feneley, MP, Post, J, Reinbott, P, Gattringer, R, Wiesbauer, F, Andrade, AR, Passos de Brito, AC, Guimaraes, AC, Grinberg, M, Mansur, AJ, Siciliano, RF, Varejao Strabelli, TM, Campos Vieira, ML, de Medeiros Tranchesi, RA, Paiva, MG, Fortes, CQ, Ramos, ADO, Ferraiuoli, G, Golebiovski, W, Lamas, C, Santos, M, Weksler, C, Karlowsky, JA, Keynan, Y, Morris, AM, Rubinstein, E, Jones, SB, Garcia, P, Cereceda, M, Fica, A, Mella, RM, Barsic, B, Bukovski, S, Krajinovic, V, Pangercic, A, Rudez, I, Vincelj, J, Freiberger, T, Pol, J, Zaloudikova, B, Ashour, Z, El Kholy, A, Mishaal, M, Rizk, H, Aissa, N, Alauzet, C, Alla, F, Campagnac, C, Doco-Lecompte, T, Selton-Suty, C, Casalta, J-P, Fournier, P-E, Habib, G, Raoult, D, Thuny, F, Delahaye, F, Delahaye, A, Vandenesch, F, Donal, E, Donnio, PY, Michelet, C, Revest, M, Tattevin, P, Violette, J, Chevalier, F, Jeu, A, Dan, Rusinaru, Sorel, C, Tribouilloy, C, Bernard, Y, Chirouze, C, Hoen, B, Leroy, J, Plesiat, P, Naber, C, Neuerburg, C, Mazaheri, B, Athanasia, S, Giannitsioti, E, Mylona, E, Paniara, O, Papanicolaou, K, Pyros, J, Skoutelis, A, Sharma, G, Francis, J, Nair, L, Thomas, V, Venugopal, K, Hannan, M, Hurley, J, Gilon, D, Israel, S, Korem, M, Strahilevitz, J, Tripodi, MF, Casillo, R, Cuccurullo, S, Dialetto, G, Durante-Mangoni, E, Irene, M, Ragone, E, Utili, R, Cecchi, E, De Rosa, F, Imazio, M, Trinchero, R, Tebini, A, Grossi, P, Lattanzio, M, Toniolo, A, Goglio, A, Raglio, A, Ravasio, V, Rizzi, M, Suter, F, Carosi, G, Magri, S, Signorini, L, Baban, T, Kanafani, Z, Kanj, SS, Sfeir, J, Yasmine, M, Abidin, I, Tamin, SS, Martinez, ER, Nieto, GIS, van der Meer, JTM, Chambers, S, Murdoch, DR, Dragulescu, S, Ionac, A, Mornos, C, Butkevich, OM, Chipigina, N, Kirill, O, Vadim, K, Edathodu, J, Halim, M, Lum, L-N, Tan, R-S, Lejko-Zupanc, T, Logar, M, Mueller-Premru, M, Commerford, P, Commerford, A, Deetlefs, E, Hansa, C, Ntsekhe, M, Armero, Y, Azqueta, M, Castaneda, X, Cervera, C, Falces, C, Garcia-de-la-Maria, C, Fita, G, Gatell, JM, Marco, F, Mestres, CA, Miro, JM, Moreno, A, Ninot, S, Pare, C, Pericas, J, Ramirez, J, Rovira, I, Sitges, M, Anguera, I, Font, B, Guma, JR, Bermejo, J, Garcia Fernandez, MA, Gonzalez-Ramallo, V, Marin, M, Munoz, P, Pedromingo, M, Roda, J, Rodriguez-Creixems, M, Solis, J, Tornos, P, de Alarcon, A, Parra, R, Alestig, E, Johansson, M, Olaison, L, Snygg-Martin, U, Pachirat, O, Pachirat, P, Pussadhamma, B, Senthong, V, Casey, A, Elliott, T, Lambert, P, Watkin, R, Eyton, C, Klein, JL, Bradley, S, Kauffman, C, Bedimo, R, Crowley, AL, Douglas, P, Drew, L, Fowler, VG, Holland, T, Mudrick, D, Samad, Z, Sexton, D, Stryjewski, M, Wang, A, Lerakis, S, Cantey, R, Steed, L, Dickerman, SA, Bonilla, H, DiPersio, J, Salstrom, S-J, Baddley, J, Patel, M, Peterson, G, Stancoven, A, Afonso, L, Kulman, T, Levine, D, Rybak, M, Cabell, CH, Baloch, K, Dixon, CC, Harding, T, Jones-Richmond, M, Park, LP, Redick, T, Stafford, J, Anstrom, K, Bayer, AS, Karchmer, AW, Sexton, DJ, Chu, V, Durack, DT, Phil, D, Eykyn, S, Moreillon, P, Abbate, A, Chambers, ST, Murdoch, D, Morris, A, Holland, D, Pappas, P, Almela, M, Fernandez-Hidalgo, N, Almirante, B, Bouza, E, Forno, D, del Rio, A, Hannan, MM, Harkness, J, Kanafani, ZA, Lalani, T, Lang, S, Raymond, N, Read, K, Vinogradova, T, Woods, CW, Wray, D, Corey, GR, Chu, VH, Clara, L, Sanchez, M, Nacinovich, F, Fernandez Oses, P, Ronderos, R, Sucari, A, Thierer, J, Casabe, J, Cortes, C, Altclas, J, Kogan, S, Spelman, D, Athan, E, Harris, O, Kennedy, K, Tan, R, Gordon, D, Papanicolas, L, Eisen, D, Grigg, L, Street, A, Korman, T, Kotsanas, D, Dever, R, Jones, P, Konecny, P, Lawrence, R, Rees, D, Ryan, S, Feneley, MP, Post, J, Reinbott, P, Gattringer, R, Wiesbauer, F, Andrade, AR, Passos de Brito, AC, Guimaraes, AC, Grinberg, M, Mansur, AJ, Siciliano, RF, Varejao Strabelli, TM, Campos Vieira, ML, de Medeiros Tranchesi, RA, Paiva, MG, Fortes, CQ, Ramos, ADO, Ferraiuoli, G, Golebiovski, W, Lamas, C, Santos, M, Weksler, C, Karlowsky, JA, Keynan, Y, Morris, AM, Rubinstein, E, Jones, SB, Garcia, P, Cereceda, M, Fica, A, Mella, RM, Barsic, B, Bukovski, S, Krajinovic, V, Pangercic, A, Rudez, I, Vincelj, J, Freiberger, T, Pol, J, Zaloudikova, B, Ashour, Z, El Kholy, A, Mishaal, M, Rizk, H, Aissa, N, Alauzet, C, Alla, F, Campagnac, C, Doco-Lecompte, T, Selton-Suty, C, Casalta, J-P, Fournier, P-E, Habib, G, Raoult, D, Thuny, F, Delahaye, F, Delahaye, A, Vandenesch, F, Donal, E, Donnio, PY, Michelet, C, Revest, M, Tattevin, P, Violette, J, Chevalier, F, Jeu, A, Dan, Rusinaru, Sorel, C, Tribouilloy, C, Bernard, Y, Chirouze, C, Hoen, B, Leroy, J, Plesiat, P, Naber, C, Neuerburg, C, Mazaheri, B, Athanasia, S, Giannitsioti, E, Mylona, E, Paniara, O, Papanicolaou, K, Pyros, J, Skoutelis, A, Sharma, G, Francis, J, Nair, L, Thomas, V, Venugopal, K, Hannan, M, Hurley, J, Gilon, D, Israel, S, Korem, M, Strahilevitz, J, Tripodi, MF, Casillo, R, Cuccurullo, S, Dialetto, G, Durante-Mangoni, E, Irene, M, Ragone, E, Utili, R, Cecchi, E, De Rosa, F, Imazio, M, Trinchero, R, Tebini, A, Grossi, P, Lattanzio, M, Toniolo, A, Goglio, A, Raglio, A, Ravasio, V, Rizzi, M, Suter, F, Carosi, G, Magri, S, Signorini, L, Baban, T, Kanafani, Z, Kanj, SS, Sfeir, J, Yasmine, M, Abidin, I, Tamin, SS, Martinez, ER, Nieto, GIS, van der Meer, JTM, Chambers, S, Murdoch, DR, Dragulescu, S, Ionac, A, Mornos, C, Butkevich, OM, Chipigina, N, Kirill, O, Vadim, K, Edathodu, J, Halim, M, Lum, L-N, Tan, R-S, Lejko-Zupanc, T, Logar, M, Mueller-Premru, M, Commerford, P, Commerford, A, Deetlefs, E, Hansa, C, Ntsekhe, M, Armero, Y, Azqueta, M, Castaneda, X, Cervera, C, Falces, C, Garcia-de-la-Maria, C, Fita, G, Gatell, JM, Marco, F, Mestres, CA, Miro, JM, Moreno, A, Ninot, S, Pare, C, Pericas, J, Ramirez, J, Rovira, I, Sitges, M, Anguera, I, Font, B, Guma, JR, Bermejo, J, Garcia Fernandez, MA, Gonzalez-Ramallo, V, Marin, M, Munoz, P, Pedromingo, M, Roda, J, Rodriguez-Creixems, M, Solis, J, Tornos, P, de Alarcon, A, Parra, R, Alestig, E, Johansson, M, Olaison, L, Snygg-Martin, U, Pachirat, O, Pachirat, P, Pussadhamma, B, Senthong, V, Casey, A, Elliott, T, Lambert, P, Watkin, R, Eyton, C, Klein, JL, Bradley, S, Kauffman, C, Bedimo, R, Crowley, AL, Douglas, P, Drew, L, Fowler, VG, Holland, T, Mudrick, D, Samad, Z, Sexton, D, Stryjewski, M, Wang, A, Lerakis, S, Cantey, R, Steed, L, Dickerman, SA, Bonilla, H, DiPersio, J, Salstrom, S-J, Baddley, J, Patel, M, Peterson, G, Stancoven, A, Afonso, L, Kulman, T, Levine, D, Rybak, M, Cabell, CH, Baloch, K, Dixon, CC, Harding, T, Jones-Richmond, M, Park, LP, Redick, T, Stafford, J, Anstrom, K, Bayer, AS, Karchmer, AW, Sexton, DJ, Chu, V, Durack, DT, Phil, D, Eykyn, S, and Moreillon, P
- Abstract
The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p<0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p<0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p<0.01) and younger age (OR 0.62; CI 0.49-0.90; p<0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p<0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.
- Published
- 2013
20. Warfarin therapy and incidence of cerebrovascular complications in left-sided native valve endocarditis
- Author
-
Snygg-Martin, U, Rasmussen, Rasmus Vedby, Hassager, C, Bruun, N E, Andersson, R, Olaison, Lars, Snygg-Martin, U, Rasmussen, Rasmus Vedby, Hassager, C, Bruun, N E, Andersson, R, and Olaison, Lars
- Abstract
Anticoagulant therapy has been anticipated to increase the risk of cerebrovascular complications (CVC) in native valve endocarditis (NVE). This study investigates the relationship between ongoing oral anticoagulant therapy and the incidence of symptomatic CVC in left-sided NVE. In a prospective cohort study, the CVC incidence was compared between NVE patients with and without ongoing warfarin. Among 587 NVE episodes, 48 (8%) occurred in patients on warfarin. A symptomatic CVC was seen in 144 (25%) patients, with only three on warfarin. CVC were significantly less frequent in patients on warfarin (6% vs. 26%, odds ratio [OR] 0.20, 95% confidence interval [CI] 0.06-0.6, p¿=¿0.006). No increase in haemorrhagic lesions was detected in patients on warfarin. Staphylococcus aureus aetiology (adjusted OR [aOR] 6.3, 95% CI 3.8-10.4) and vegetation length (aOR 1.04, 96% CI 1.01-1.07) were risk factors for CVC, while warfarin on admission (aOR 0.26, 95% CI 0.07-0.94), history of congestive heart failure (adjusted OR 0.22, 95% CI 0.1-0.52) and previous endocarditis (aOR 0.1, 95% CI 0.01-0.79) correlated with lower CVC frequency.
- Published
- 2011
21. Non-HACEK gram-negative bacillus endocarditis.
- Author
-
Delahaye F., Patel M., Dismukes W., Pan A., Caros G., Tribouilloy A.B.M.C., Ramallo V., Raoult D., Thuny F., Habib G., Casalta J.-P., Fournier P.-E., Chipigina N., Kirill O., Vinogradova T., Kulichenko V.P., Butkevich O.M., Lion C., Selton-Suty C., Alla F., Coyard H., Doco-Lecompte T., Durante-Mangoni E., Ragone E., Dialetto G., Tripodi M.F., Utili R., Casillo R., Kumar A.S., Sharma G., Street A., Eisen D.P., McBryde E.S., Grigg L., Abrutyn E., Michelet C., Donnio P.Y., Fortes C.Q., Edathodu J., Al-Hegelan M., Font B., Anguera I., Guma J.R., Cereceda M., Oyonarte M.J., Mella R.M., Garcia P., Jones S.B., Paiva M.G., Tranchesi R.A.D.M., Woon L.L., Lum L.-N., Tan R.-S., Rees D., Kornecny P., Lawrence R., Dever R., Post J., Jones P., Ryan S., Harkness J., Feneley M., Rubinstein E., Strahilewitz J., Ionac A., Mornos C., Dragulescu S., Forno D., Cecchi E., De Rosa F., Imazio M., Trinchero R., Wiesbauer F., Gattringer R., Deans G., Andrasevic A.T., Barsic B., Klinar I., Vincelj J., Bukovski S., Krajinovic V., Stafford J., Baloch K., Redick T., Harding T., Bayer A.S., Durack D.T., Moreillon P., Eykyn S., Morpeth S., Murdoch D., Cabell C.H., Karchmer A.W., Pappas P., Levine D., Nacinovich F., Tattevin P., Fernandez-Hidalgo N., Dickerman S., Bouza E., Del Rio A., Lejko-Zupanc T., De Oliveira Ramos A., Iarussi D., Klein J., Chirouze C., Bedimo R., Corey G.R., Fowler Jr. V.G., Gordon D., Devi U., Spelman D., Van Der Meer J.T.M., Kauffman C., Bradley S., Armstrong W., Giannitsioti E., Giamarellou H., Lerakis S., Moreno A., Mestres C.A., Pare C., Garcia De La Maria C., De Lazzario E., Marco F., Gatell J.M., Miro J.M., Almela M., Azqueta M., Jimenez-Exposito M.J., De Benito N., Perez N., Almirante B., Rodriguez De Vera P., Tornos P., Falco V., Claramonte X., Armero Y., Sidani N., Kanj-Sharara S., Kanafani Z., Raglio A., Goglio A., Gnecchi F., Suter F., Valsecchi G., Rizzi M., Ravasio V., Hoen B., Leroy J., Plesiat P., Bernard Y., Casey A., Lambert P., Watkin R., Elliott T., Goissen T., Delahaye A., Vandenesch F., Vizzotti C., Nacinovich F.M., Trivi M., Lombardero M., Cortes C., Casabe J.H., Altclas J., Kogan S., Clara L., Sanchez M., Commerford A., Hansa C., Deetlefs E., Ntsekhe M., Commerford P., Wray D., Steed L.L., Church P., Cantey R., Morris A., Chambers S., Read K., Raymond N., Holland D., Lang S., Kotsanas D., Korman T.M., Peterson G., Purcell J., Southern Jr. P.M., Shah M., Reddy A., Dhar G., Hanlon-Feeney A., Hannan M., Kelly S., Wang A., Woods C.W., Sexton D.J., Benjamin Jr. D., McDonald J.R., Federspiel J., Engemann J.J., Reller L.B., Drew L., Caram L.B., Stryjewski M., Lalani T., Chu V., Mazaheri B., Neuerburg C., Naber C., Athan E., Henry M., Harris O., Alestig E., Olaison L., Wikstrom L., Snygg-Martin U., Francis J., Venugopal K., Nair L., Thomas V., Chaiworramukkun J., Pachirat O., Chetchotisakd P., Suwanich T., Kamarulzaman A., Tamin S.S., Mueller Premru M., Logar M., Orezzi C., Moreno M., Rodriguez-Creixems M., Marin M., Fernandez M., Munoz P., Fernandez R., Delahaye F., Patel M., Dismukes W., Pan A., Caros G., Tribouilloy A.B.M.C., Ramallo V., Raoult D., Thuny F., Habib G., Casalta J.-P., Fournier P.-E., Chipigina N., Kirill O., Vinogradova T., Kulichenko V.P., Butkevich O.M., Lion C., Selton-Suty C., Alla F., Coyard H., Doco-Lecompte T., Durante-Mangoni E., Ragone E., Dialetto G., Tripodi M.F., Utili R., Casillo R., Kumar A.S., Sharma G., Street A., Eisen D.P., McBryde E.S., Grigg L., Abrutyn E., Michelet C., Donnio P.Y., Fortes C.Q., Edathodu J., Al-Hegelan M., Font B., Anguera I., Guma J.R., Cereceda M., Oyonarte M.J., Mella R.M., Garcia P., Jones S.B., Paiva M.G., Tranchesi R.A.D.M., Woon L.L., Lum L.-N., Tan R.-S., Rees D., Kornecny P., Lawrence R., Dever R., Post J., Jones P., Ryan S., Harkness J., Feneley M., Rubinstein E., Strahilewitz J., Ionac A., Mornos C., Dragulescu S., Forno D., Cecchi E., De Rosa F., Imazio M., Trinchero R., Wiesbauer F., Gattringer R., Deans G., Andrasevic A.T., Barsic B., Klinar I., Vincelj J., Bukovski S., Krajinovic V., Stafford J., Baloch K., Redick T., Harding T., Bayer A.S., Durack D.T., Moreillon P., Eykyn S., Morpeth S., Murdoch D., Cabell C.H., Karchmer A.W., Pappas P., Levine D., Nacinovich F., Tattevin P., Fernandez-Hidalgo N., Dickerman S., Bouza E., Del Rio A., Lejko-Zupanc T., De Oliveira Ramos A., Iarussi D., Klein J., Chirouze C., Bedimo R., Corey G.R., Fowler Jr. V.G., Gordon D., Devi U., Spelman D., Van Der Meer J.T.M., Kauffman C., Bradley S., Armstrong W., Giannitsioti E., Giamarellou H., Lerakis S., Moreno A., Mestres C.A., Pare C., Garcia De La Maria C., De Lazzario E., Marco F., Gatell J.M., Miro J.M., Almela M., Azqueta M., Jimenez-Exposito M.J., De Benito N., Perez N., Almirante B., Rodriguez De Vera P., Tornos P., Falco V., Claramonte X., Armero Y., Sidani N., Kanj-Sharara S., Kanafani Z., Raglio A., Goglio A., Gnecchi F., Suter F., Valsecchi G., Rizzi M., Ravasio V., Hoen B., Leroy J., Plesiat P., Bernard Y., Casey A., Lambert P., Watkin R., Elliott T., Goissen T., Delahaye A., Vandenesch F., Vizzotti C., Nacinovich F.M., Trivi M., Lombardero M., Cortes C., Casabe J.H., Altclas J., Kogan S., Clara L., Sanchez M., Commerford A., Hansa C., Deetlefs E., Ntsekhe M., Commerford P., Wray D., Steed L.L., Church P., Cantey R., Morris A., Chambers S., Read K., Raymond N., Holland D., Lang S., Kotsanas D., Korman T.M., Peterson G., Purcell J., Southern Jr. P.M., Shah M., Reddy A., Dhar G., Hanlon-Feeney A., Hannan M., Kelly S., Wang A., Woods C.W., Sexton D.J., Benjamin Jr. D., McDonald J.R., Federspiel J., Engemann J.J., Reller L.B., Drew L., Caram L.B., Stryjewski M., Lalani T., Chu V., Mazaheri B., Neuerburg C., Naber C., Athan E., Henry M., Harris O., Alestig E., Olaison L., Wikstrom L., Snygg-Martin U., Francis J., Venugopal K., Nair L., Thomas V., Chaiworramukkun J., Pachirat O., Chetchotisakd P., Suwanich T., Kamarulzaman A., Tamin S.S., Mueller Premru M., Logar M., Orezzi C., Moreno M., Rodriguez-Creixems M., Marin M., Fernandez M., Munoz P., and Fernandez R.
- Abstract
Background: Infective endocarditis caused by non-HACEK (species other than Haemophilus species, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, or Kingella species) gram-negative bacilli is rare, is poorly characterized, and is commonly considered to be primarily a disease of injection drug users. Objective(s): To describe the clinical characteristics and outcomes of patients with non-HACEK gram-negative bacillus endocarditis in a large, international, contemporary cohort of patients. Design(s): Observations from the International Collaboration on Infective Endocarditis Prospective Cohort Study (ICE-PCS) database. Setting(s): 61 hospitals in 28 countries. Patient(s): Hospitalized patients with definite endocarditis. Measurements: Characteristics of non-HACEK gram-negative bacillus endocarditis cases were described and compared with those due to other pathogens. Result(s): Among the 2761 case-patients with definite endocarditis enrolled in ICE-PCS, 49 (1.8%) had endocarditis (20 native valve, 29 prosthetic valve or device) due to non-HACEK, gram-negative bacilli. Escherichia coli (14 patients [29%]) and Pseudomonas aeruginosa (11 patients [22%]) were the most common pathogens. Most patients (57%) with non-HACEK gram-negative bacillus endocarditis had health care-associated infection, whereas injection drug use was rare (4%). Implanted endovascular devices were frequently associated with non-HACEK gram-negative bacillus endocarditis compared with other causes of endocarditis (29% vs. 11%; P < 0.001). The in-hospital mortality rate of patients with endocarditis due to non-HACEK gram-negative bacilli was high (24%) despite high rates of cardiac surgery (51%). Limitation(s): Because of the small number of patients with non-HACEK gram-negative bacillus endocarditis in each treatment group and the lack of long-term follow-up, strong treatment recommendations are difficult to make. Conclusion(s): In this large, prospective, multinational
- Published
- 2008
22. P70 NEPHROTOXICITY DURING AMINOGLYCOSIDE THERAPY FOR ENDOCARDITIS
- Author
-
Johansson, N., primary, Sandberg, T., additional, Snygg-Martin, U., additional, and Olaison, L., additional
- Published
- 2013
- Full Text
- View/download PDF
23. SY.4.4 EMBOLIZATIONS OF THE CENTRAL NERVOUS SYSTEM IS THERE MORE THAN WE OBSERVE?
- Author
-
Snygg-Martin, U., primary
- Published
- 2013
- Full Text
- View/download PDF
24. Warfarin therapy and incidence of cerebrovascular complications in left-sided native valve endocarditis
- Author
-
Snygg-Martin, U., primary, Rasmussen, R. V., additional, Hassager, C., additional, Bruun, N. E., additional, Andersson, R., additional, and Olaison, L., additional
- Published
- 2010
- Full Text
- View/download PDF
25. 069 COMPUTED TOMOGRAPHY AS A TOOL FOR DIAGNOSING AORTIC ROOT ABSCESS IN PROSTHETIC VALVE ENDOCARDITIS. A CASE REPORT
- Author
-
Ericsson, M., primary, Snygg-Martin, U., additional, Lamm, C., additional, and Olaison, L., additional
- Published
- 2009
- Full Text
- View/download PDF
26. 080 GENDER DIFFERENCES IN CEREBROVASCULAR COMPLICATIONS IN INFECTIVE ENDOCARDITIS
- Author
-
Snygg-Martin, U., primary, Rasmussen, R., additional, Hassager, C., additional, Bruun, N., additional, Ericsson, M., additional, Andersson, R., additional, and Olaison, L., additional
- Published
- 2009
- Full Text
- View/download PDF
27. Non-HACEK gram-negative bacillus endocarditis
- Author
-
Morpeth, S, Murdoch, D, Cabell, Ch, Karchmer, Aw, Pappas, P, Levine, D, Nacinovich, F, Tattevin, P, Fernández Hidalgo, N, Dickerman, S, Bouza, E, del Río, A, Lejko Zupanc, T, de Oliveira Ramos, A, Iarussi, D, Klein, J, Chirouze, C, Bedimo, R, Corey, Gr, Fowler VG Jr, Collaborators: Gordon D, International Collaboration on Endocarditis Prospective Cohort Study I. n. v. e. s. t. i. g. a. t. o. r. s., Devi, U, Spelman, D, van der Meer JT, Kauffman, C, Bradley, S, Armstrong, W, Giannitsioti, E, Giamarellou, H, Lerakis, S, del Rio, A, Moreno, A, Mestres, Ca, Paré, C, Garcia de la Maria, C, De Lazzario, E, Marco, F, Gatell, Jm, Miró, Jm, Almela, M, Azqueta, M, Jiménez Expósito MJ, de Benito, N, Perez, N, Almirante, B, Fernandez Hidalgo, N, Rodriguez de Vera, P, Tornos, P, Falcó, V, Claramonte, X, Armero, Y, Sidani, N, Kanj Sharara, S, Kanafani, Z, Raglio, A, Goglio, A, Gnecchi, F, Suter, F, Valsecchi, G, Rizzi, M, Ravasio, V, Hoen, B, Leroy, J, Plesiat, P, Bernard, Y, Casey, A, Lambert, P, Watkin, R, Elliott, T, Patel, M, Dismukes, W, Pan, A, Caros, G, Tribouilloy, Ab, Goissen, T, Delahaye, A, Delahaye, F, Vandenesch, F, Vizzotti, C, Nacinovich, Fm, Marin, M, Trivi, M, Lombardero, M, Cortes, C, Horacio Casabe, J, Altclas, J, Kogan, S, Clara, L, Sanchez, M, Commerford, A, Hansa, C, Deetlefs, E, Ntsekhe, M, Commerford, P, Wray, D, Steed, Ll, Church, P, Cantey, R, Morris, A, Read, K, Raymond, N, Lang, S, Chambers, S, Kotsanas, D, Korman, Tm, Peterson, G, Purcell, J, Southern PM Jr, Shah, M, Reddy, A, Dhar, G, Hanlon Feeney, A, Hannan, M, Kelly, S, Wang, A, Woods, Cw, Sexton, Dj, Benjamin D., Jr, Mcdonald, Jr, Federspiel, J, Engemann, Jj, Reller, Lb, Drew, L, Caram, Lb, Stryjewski, M, Lalani, T, Fowler V., Jr, Chu, V, Mazaheri, B, Neuerburg, C, Naber, C, Athan, E, Henry, M, Harris, O, Alestig, E, Olaison, L, Wikstrom, L, Snygg Martin, U, Francis, J, Venugopal, K, Nair, L, Thomas, V, Chaiworramukkun, J, Pachirat, O, Chetchotisakd, P, Suwanich, T, Kamarulzaman, A, Tamin, Ss, Premru, Mm, Logar, M, Orezzi, C, Moreno, M, Rodríguez Créixems, M, Fernández, M, Muñoz, P, Fernández, R, Ramallo, V, Raoult, D, Thuny, F, Habib, G, Casalta, Jp, Fournier, Pe, Chipigina, N, Kirill, O, Vinogradova, T, Kulichenko, Vp, Butkevich, Om, Lion, C, Alla, F, Coyard, H, Doco Lecompte, T, Durante Mangoni, E, Ragone, E, Dialetto, G, Tripodi, Mf, Utili, R, Casillo, R, Kumar, As, Sharma, G, Dickerman, Sa, Street, A, Eisen, Dp, Mcbryde, Es, Grigg, L, Abrutyn, E, Michelet, C, Donnio, Py, Fortes, Cq, Edathodu, J, Al Hegelan, M, Font, B, Anguera, I, Raimon Guma, J, Cereceda, M, Oyonarte, Mj, Montagna Mella, R, Garcia, P, Braun Jones, S, de Oliveira Ramos AI, Paiva, Mg, de Medeiros RA, Woon, Ll, Lum, Ln, Tan, Rs, Rees, D, Koneçny, P, Lawrence, R, Dever, R, Post, J, Jones, P, Ryan, S, Harkness, J, Feneley, M, Rubinstein, E, Strahilewitz, J, Ionac, A, Mornos, C, Dragulescu, S, Forno, D, Cecchi, E, DE ROSA, Francesco Giuseppe, Imazio, M, Trinchero, R, Wiesbauer, F, Gattringer, R, Deans, G, Andrasevic, At, Barsic, B, Klinar, I, Vincelj, J, Bukovski, S, Krajinovic, V, Cabell, C, Stafford, J, Baloch, K, Redick, T, Harding, T, Bayer, A, Durack, Dt, Corey, R, Moreillon, P, Eykynm, S, and Chu, V.
- Subjects
Eikenella corrodens ,Microbiology ,stomatognathic system ,Haemophilus ,Gram-Negative Bacteria ,Internal Medicine ,medicine ,Endocarditis ,Humans ,Prospective Studies ,Cardiac Surgical Procedures ,Substance Abuse, Intravenous ,Cross Infection ,biology ,business.industry ,Gram Negative Bacillus ,General Medicine ,Endocarditis, Bacterial ,Prostheses and Implants ,biology.organism_classification ,medicine.disease ,Anti-Bacterial Agents ,Community-Acquired Infections ,stomatognathic diseases ,Treatment Outcome ,Infective endocarditis ,Bacteremia ,Actinobacillus ,bacteria ,Cardiobacterium hominis ,business ,Gram-Negative Bacterial Infections - Abstract
Infective endocarditis caused by non-HACEK (species other than Haemophilus species, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, or Kingella species) gram-negative bacilli is rare, is poorly characterized, and is commonly considered to be primarily a disease of injection drug users.To describe the clinical characteristics and outcomes of patients with non-HACEK gram-negative bacillus endocarditis in a large, international, contemporary cohort of patients.Observations from the International Collaboration on Infective Endocarditis Prospective Cohort Study (ICE-PCS) database.61 hospitals in 28 countries.Hospitalized patients with definite endocarditis.Characteristics of non-HACEK gram-negative bacillus endocarditis cases were described and compared with those due to other pathogens.Among the 2761 case-patients with definite endocarditis enrolled in ICE-PCS, 49 (1.8%) had endocarditis (20 native valve, 29 prosthetic valve or device) due to non-HACEK, gram-negative bacilli. Escherichia coli (14 patients [29%]) and Pseudomonas aeruginosa (11 patients [22%]) were the most common pathogens. Most patients (57%) with non-HACEK gram-negative bacillus endocarditis had health care-associated infection, whereas injection drug use was rare (4%). Implanted endovascular devices were frequently associated with non-HACEK gram-negative bacillus endocarditis compared with other causes of endocarditis (29% vs. 11%; P0.001). The in-hospital mortality rate of patients with endocarditis due to non-HACEK gram-negative bacilli was high (24%) despite high rates of cardiac surgery (51%).Because of the small number of patients with non-HACEK gram-negative bacillus endocarditis in each treatment group and the lack of long-term follow-up, strong treatment recommendations are difficult to make.In this large, prospective, multinational cohort, more than one half of all cases of non-HACEK gram-negative bacillus endocarditis were associated with health care contact. Non-HACEK gram-negative bacillus endocarditis is not primarily a disease of injection drug users.
28. Infective Endocarditis in Patients on Chronic Hemodialysis
- Author
-
Juan M. Pericàs, Jaume Llopis, Maria Jesús Jiménez-Exposito, Wissam M. Kourany, Benito Almirante, Giampiero Carosi, Emanuele Durante-Mangoni, Claudio Querido Fortes, Efthymia Giannitsioti, Stamatios Lerakis, Rodrigo Montagna-Mella, Juan Ambrosioni, Ru-San Tan, Carlos A. Mestres, Dannah Wray, Orathai Pachirat, Asuncion Moreno, Vivian H. Chu, Elisa de Lazzari, Vance G. Fowler, Jose M. Miró, Liliana Clara, Marisa Sanchez, José Casabé, Claudia Cortes, Francisco Nacinovich, Pablo Fernandez Oses, Ricardo Ronderos, Adriana Sucari, Jorge Thierer, Javier Altclas, Silvia Kogan, Denis Spelman, Eugene Athan, Owen Harris, Karina Kennedy, Ren Tan, David Gordon, Lito Papanicolas, Tony Korman, Despina Kotsanas, Robyn Dever, Phillip Jones, Pam Konecny, Richard Lawrence, David Rees, Suzanne Ryan, Michael P. Feneley, John Harkness, Jeffrey Post, Porl Reinbott, Rainer Gattringer, Franz Wiesbauer, Adriana Ribas Andrade, Ana Cláudia Passos de Brito, Armenio Costa Guimarães, Max Grinberg, Alfredo José Mansur, Rinaldo Focaccia Siciliano, Tania Mara Varejao Strabelli, Marcelo Luiz Campos Vieira, Regina Aparecida de Medeiros Tranchesi, Marcelo Goulart Paiva, Auristela de Oliveira Ramos, Clara Weksler, Giovanna Ferraiuoli, Wilma Golebiovski, Cristiane Lamas, James A. Karlowsky, Yoav Keynan, Andrew M. Morris, Ethan Rubinstein, Sandra Braun Jones, Patricia Garcia, M. Cereceda, Alberto Fica, Rodrigo Montagna Mella, Ricardo Fernandez, Liliana Franco, Javier Gonzalez, Astrid Natalia Jaramillo, Bruno Barsic, Suzana Bukovski, Vladimir Krajinovic, Ana Pangercic, Igor Rudez, Josip Vincelj, Tomas Freiberger, Jiri Pol, Barbora Zaloudikova, Zainab Ashour, Amani El Kholy, Marwa Mishaal, Dina Osama, Hussien Rizk, Neijla Aissa, Corentine Alauzet, Francois Alla, CHU Catherine Campagnac, Thanh Doco-Lecompte, Christine Selton-Suty, Jean-Paul Casalta, Pierre-Edouard Fournier, Gilbert Habib, Didier Raoult, Franck Thuny, Francois Delahaye, Armelle Delahaye, Francois Vandenesch, Erwan Donal, Pierre Yves Donnio, Erwan Flecher, Christian Michelet, Matthieu Revest, Pierre Tattevin, Florent Chevalier, Antoine Jeu, Jean Paul Rémadi, Dan Rusinaru, Christophe Tribouilloy, Yvette Bernard, Catherine Chirouze, Bruno Hoen, Joel Leroy, Patrick Plesiat, Christoph Naber, Carl Neuerburg, Bahram Mazaheri, Carl Neuerburg Sophia Athanasia, Ioannis Deliolanis, Helen Giamarellou, Tsaganos Thomas, Elena Mylona, Olga Paniara, Konstantinos Papanicolaou, John Pyros, Athanasios Skoutelis, Konstantinos Papanikolaou, Gautam Sharma, Johnson Francis, Lathi Nair, Vinod Thomas, Krishnan Venugopal, Margaret M. Hannan, John P. Hurley, Maor Wanounou, Dan Gilon, Sarah Israel, Maya Korem, Jacob Strahilevitz, Domenico Iossa, Serena Orlando, Maria Paola Ursi, Pia Clara Pafundi, Fabiana D’Amico, Mariano Bernardo, Susanna Cuccurullo, Giovanni Dialetto, Franco Enrico Covino, Sabrina Manduca, Alessandro Della Corte, Marisa De Feo, Marie Françoise Tripodi, Enrico Cecchi, Francesco De Rosa, Davide Forno, Massimo Imazio, Rita Trinchero, Paolo Grossi, Mariangela Lattanzio, Antonio Toniolo, Antonio Goglio, Annibale Raglio, Veronica Ravasio, Marco Rizzi, Fredy Suter, Silvia Magri, Liana Signorini, Zeina Kanafani, Souha S. Kanj, Ahmad Sharif-Yakan, Imran Abidin, Syahidah Syed Tamin, Eduardo Rivera Martínez, Gabriel Israel Soto Nieto, Jan T.M. van der Meer, Stephen Chambers, David Holland, Arthur Morris, Nigel Raymond, Kerry Read, David R. Murdoch, Stefan Dragulescu, Adina Ionac, Cristian Mornos, O.M. Butkevich, Natalia Chipigina, Ozerecky Kirill, Kulichenko Vadim, Tatiana Vinogradova, Jameela Edathodu, Magid Halim, Yee-Yun Liew, Tatjana Lejko-Zupanc, Mateja Logar, Manica Mueller-Premru, Patrick Commerford, Anita Commerford, Eduan Deetlefs, Cass Hansa, Mpiko Ntsekhe, Manel Almela, Manuel Azqueta, Merce Brunet, Pedro Castro, Elisa De Lazzari, Carlos Falces, David Fuster, Guillermina Fita, Cristina Garcia- de- la- Maria, Javier Garcia-Gonzalez, Jose M. Gatell, Francesc Marco, José M. Miró, José Ortiz, Salvador Ninot, J. Carlos Paré, Juan M. Pericas, Eduard Quintana, Jose Ramirez, Irene Rovira, Elena Sandoval, Marta Sitges, Adrian Tellez, José M. Tolosana, Barbara Vidal, Jordi Vila, Ignasi Anguera, Bernat Font, Joan Raimon Guma, Javier Bermejo, Emilio Bouza, Miguel Angel Garcia Fernández, Victor Gonzalez-Ramallo, Mercedes Marín, Patricia Muñoz, Miguel Pedromingo, Jorge Roda, Marta Rodríguez-Créixems, Jorge Solis, Nuria Fernandez-Hidalgo, Pilar Tornos, Arístides de Alarcón, Ricardo Parra, Eric Alestig, Magnus Johansson, Lars Olaison, Ulrika Snygg-Martin, Pimchitra Pachirat, Burabha Pussadhamma, Vichai Senthong, Anna Casey, Tom Elliott, Peter Lambert, Richard Watkin, Christina Eyton, John L. Klein, Suzanne Bradley, Carol Kauffman, Roger Bedimo, G. Ralph Corey, Anna Lisa Crowley, Pamela Douglas, Laura Drew, Thomas Holland, Tahaniyat Lalani, Daniel Mudrick, Zaniab Samad, Daniel Sexton, Martin Stryjewski, Andrew Wang, Christopher W. Woods, Robert Cantey, Lisa Steed, Stuart A. Dickerman, Hector Bonilla, Joseph DiPersio, Sara-Jane Salstrom, John Baddley, Mukesh Patel, Gail Peterson, Amy Stancoven, Donald Levine, Jonathan Riddle, Michael Rybak, Christopher H. Cabell, Pericas, J. M., Llopis, J., Jimenez-Exposito, M. J., Kourany, W. M., Almirante, B., Carosi, G., Durante-Mangoni, E., Fortes, C. Q., Giannitsioti, E., Lerakis, S., Montagna-Mella, R., Ambrosioni, J., Tan, R. -S., Mestres, C. A., Wray, D., Pachirat, O., Moreno, A., Chu, V. H., de Lazzari, E., Fowler, V. G., Miro, J. M., Clara, L., Sanchez, M., Casabe, J., Cortes, C., Nacinovich, F., Oses, P. F., Ronderos, R., Sucari, A., Thierer, J., Altclas, J., Kogan, S., Spelman, D., Athan, E., Harris, O., Kennedy, K., Tan, R., Gordon, D., Papanicolas, L., Korman, T., Kotsanas, D., Dever, R., Jones, P., Konecny, P., Lawrence, R., Rees, D., Ryan, S., Feneley, M. P., Harkness, J., Post, J., Reinbott, P., Gattringer, R., Wiesbauer, F., Andrade, A. R., Passos de Brito, A. C., Guimaraes, A. C., Grinberg, M., Mansur, A. J., Siciliano, R. F., Varejao Strabelli, T. M., Campos Vieira, M. L., de Medeiros Tranchesi, R. A., Paiva, M. G., de Oliveira Ramos, A., Weksler, C., Ferraiuoli, G., Golebiovski, W., Lamas, C., Karlowsky, J. A., Keynan, Y., Morris, A. M., Rubinstein, E., Jones, S. B., Garcia, P., Cereceda, M., Fica, A., Mella, R. M., Fernandez, R., Franco, L., Gonzalez, J., Jaramillo, A. N., Barsic, B., Bukovski, S., Krajinovic, V., Pangercic, A., Rudez, I., Vincelj, J., Freiberger, T., Pol, J., Zaloudikova, B., Ashour, Z., El Kholy, A., Mishaal, M., Osama, D., Rizk, H., Aissa, N., Alauzet, C., Alla, F., Campagnac, C. C., Doco-Lecompte, T., Selton-Suty, C., Casalta, J. -P., Fournier, P. -E., Habib, G., Raoult, D., Thuny, F., Delahaye, F., Delahaye, A., Vandenesch, F., Donal, E., Donnio, P. Y., Flecher, E., Michelet, C., Revest, M., Tattevin, P., Chevalier, F., Jeu, A., Remadi, J. P., Rusinaru, D., Tribouilloy, C., Bernard, Y., Chirouze, C., Hoen, B., Leroy, J., Plesiat, P., Naber, C., Neuerburg, C., Mazaheri, B., Sophia Athanasia, C. N., Deliolanis, I., Giamarellou, H., Thomas, T., Mylona, E., Paniara, O., Papanicolaou, K., Pyros, J., Skoutelis, A., Papanikolaou, K., Sharma, G., Francis, J., Nair, L., Thomas, V., Venugopal, K., Hannan, M. M., Hurley, J. P., Wanounou, M., Gilon, D., Israel, S., Korem, M., Strahilevitz, J., Iossa, D., Orlando, S., Ursi, M. P., Pafundi, P. C., D'Amico, F., Bernardo, M., Cuccurullo, S., Dialetto, G., Covino, F. E., Manduca, S., Della Corte, A., De Feo, M., Tripodi, M. F., Cecchi, E., De Rosa, F., Forno, D., Imazio, M., Trinchero, R., Grossi, P., Lattanzio, M., Toniolo, A., Goglio, A., Raglio, A., Ravasio, V., Rizzi, M., Suter, F., Magri, S., Signorini, L., Kanafani, Z., Kanj, S. S., Sharif-Yakan, A., Abidin, I., Tamin, S. S., Martinez, E. R., Soto Nieto, G. I., van der Meer, J. T. M., Chambers, S., Holland, D., Morris, A., Raymond, N., Read, K., Murdoch, D. R., Dragulescu, S., Ionac, A., Mornos, C., Butkevich, O. M., Chipigina, N., Kirill, O., Vadim, K., Vinogradova, T., Edathodu, J., Halim, M., Liew, Y. -Y., Lejko-Zupanc, T., Logar, M., Mueller-Premru, M., Commerford, P., Commerford, A., Deetlefs, E., Hansa, C., Ntsekhe, M., Almela, M., Azqueta, M., Brunet, M., Castro, P., Falces, C., Fuster, D., Fita, G., Garcia- de- la- Maria, C., Garcia-Gonzalez, J., Gatell, J. M., Marco, F., Ortiz, J., Ninot, S., Pare, J. C., Quintana, E., Ramirez, J., Rovira, I., Sandoval, E., Sitges, M., Tellez, A., Tolosana, J. M., Vidal, B., Vila, J., Anguera, I., Font, B., Guma, J. R., Bermejo, J., Bouza, E., Garcia Fernandez, M. A., Gonzalez-Ramallo, V., Marin, M., Munoz, P., Pedromingo, M., Roda, J., Rodriguez-Creixems, M., Solis, J., Fernandez-Hidalgo, N., Tornos, P., de Alarcon, A., Parra, R., Alestig, E., Johansson, M., Olaison, L., Snygg-Martin, U., Pachirat, P., Pussadhamma, B., Senthong, V., Casey, A., Elliott, T., Lambert, P., Watkin, R., Eyton, C., Klein, J. L., Bradley, S., Kauffman, C., Bedimo, R., Corey, G. R., Crowley, A. L., Douglas, P., Drew, L., Holland, T., Lalani, T., Mudrick, D., Samad, Z., Sexton, D., Stryjewski, M., Wang, A., Woods, C. W., Cantey, R., Steed, L., Dickerman, S. A., Bonilla, H., Dipersio, J., Salstrom, S. -J., Baddley, J., Patel, M., Peterson, G., Stancoven, A., Levine, D., Riddle, J., Rybak, M., Cabell, C. H., Bristol-Myers Squibb Company, Vall d'Hebron University Hospital [Barcelona], Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Laboratoire Chrono-environnement (UMR 6249) (LCE)
- Subjects
Male ,relapses ,medicine.medical_treatment ,infective endocarditi ,030204 cardiovascular system & hematology ,Kidney Failure ,Cohort Studies ,Catheters, Indwelling ,0302 clinical medicine ,Surgical ,Epidemiology ,cardiac surgery ,enterococci ,hemodialysis ,infective endocarditis ,Staphylococcus aureus ,Aged ,Anti-Bacterial Agents ,Arteriovenous Shunt, Surgical ,Cardiac Surgical Procedures ,Endocarditis ,Female ,Humans ,Kidney Failure, Chronic ,Methicillin-Resistant Staphylococcus aureus ,Middle Aged ,Renal Dialysis ,Staphylococcal Infections ,030212 general & internal medicine ,Chronic ,Prospective cohort study ,health care economics and organizations ,relapse ,Arteriovenous Shunt ,3. Good health ,Cardiac surgery ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Indwelling ,Infective endocarditis ,Hemodialysis ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Catheters ,education ,03 medical and health sciences ,Internal medicine ,medicine ,business.industry ,medicine.disease ,hemodialysi ,Etiology ,Complication ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Background - Infective endocarditis (IE) is a common and serious complication in patients receiving chronic hemodialysis (HD). Objectives - This study sought to investigate whether there are significant differences in complications, cardiac surgery, relapses, and mortality between IE cases in HD and non-HD patients. Methods - Prospective cohort study (International Collaboration on Endocarditis databases, encompassing 7,715 IE episodes from 2000 to 2006 and from 2008 to 2012). Descriptive analysis of baseline characteristics, epidemiological and etiological features, complications and outcomes, and their comparison between HD and non-HD patients was performed. Risk factors for major embolic events, cardiac surgery, relapses, and in-hospital and 6-month mortality were investigated in HD-patients using multivariable logistic regression. Results - A total of 6,691 patients were included and 553 (8.3%) received HD. North America had a higher HD-IE proportion than the other regions. The predominant microorganism was Staphylococcus aureus (47.8%), followed by enterococci (15.4%). Both in-hospital and 6-month mortality were significantly higher in HD versus non-HD-IE patients (30.4% vs. 17% and 39.8% vs. 20.7%, respectively; p
- Published
- 2021
29. Clinical practice and implementation of guidelines for the prevention, diagnosis and management of cardiac implantable electronic device infections: results of a worldwide survey under the auspices of the European Heart Rhythm Association
- Author
-
Giuseppe Boriani, Christoph Starck, Ulrika Snygg-Martin, Carina Blomström-Lundqvist, László Sághy, Nikolaos Dagres, Paola Anna Erba, Roberto Costa, Haran Burri, Laurence M. Epstein, Jeanne E. Poole, Jean-Claude Deharo, Maria Grazia Bongiorni, Jens Cosedis Nielsen, Neil Strathmore, Vassil Traykov, Traykov, V, Bongiorni, M, Boriani, G, Burri, H, Costa, R, Dagres, N, Deharo, J, Epstein, L, Erba, P, Snygg-Martin, U, Nielsen, J, Poole, J, Saghy, L, Starck, C, Strathmore, N, and Blomstrom-Lundqvist, C
- Subjects
medicine.medical_specialty ,Prosthesis-Related Infections ,Heart Diseases ,medicine.medical_treatment ,SOCIETY ,Cardiac resynchronization therapy ,Guideline ,030204 cardiovascular system & hematology ,Guidelines ,Global Health ,Implantable cardioverter-defibrillator ,Prosthesis Implantation ,03 medical and health sciences ,0302 clinical medicine ,Clinical Protocols ,Physiology (medical) ,Surveys and Questionnaires ,medicine ,Secondary Prevention ,Humans ,030212 general & internal medicine ,Cardiac Resynchronization Therapy Devices ,Practice Patterns, Physicians' ,Cardiac implantable electronic device infection ,EHRA survey ,Prevention ,EXPERT CONSENSUS STATEMENT ,ddc:616 ,PACEMAKERS ,business.industry ,COST ,Surgical debridement ,Arrhythmias, Cardiac ,CARDIOVERTER-DEFIBRILLATORS ,Antibiotic Prophylaxis ,Anti-Bacterial Agents ,Defibrillators, Implantable ,Patient Care Management ,Clinical Practice ,Heart Rhythm ,Emergency medicine ,Practice Guidelines as Topic ,TRIAL ,Cardiology and Cardiovascular Medicine ,business - Abstract
Aims Cardiac implantable electronic device (CIED) infection rates are increasing. Worldwide compliance and disparities to published guidelines for the prevention, diagnosis and management of these conditions are not well elucidated. The purpose of this survey, therefore, was to clarify these issues through an inquiry to arrhythmia-related associations and societies worldwide. Methods and results A questionnaire comprising 15 questions related to CIED infections was distributed among members of seven arrhythmia societies worldwide. A total of 234 centres in 62 countries reported implantation rates of which 159 (68.0%) performed more than 200 device implantations per year and 14 (6.0%) performed fewer than 50 implantations per year. The reported rates of CIED infections for 2017 were ≤2% in 78.7% of the centres, while the infection rates exceeded 5% in 7.8% of the centres. Preventive measures for CIED infection differed from published recommendations and varied among different regions mainly in terms of pocket irrigation and administering post-operative antimicrobial therapy the use of which was reported by 39.9% and 44% of the respondents, respectively. Antibacterial envelopes were used by 37.7% of the respondents in selected circumstances. In terms of pocket infection management, 62% of the respondents applied complete system removal as an initial step. Diagnostic pocket needle aspiration and pocket surgical debridement were reported by 15.8% and 11.8% of centres, respectively. Conclusion Clinical practices for prevention and management of CIED do not fully comply with current recommendations and demonstrate considerable regional disparities. Further education and programmes for improved implementation of guidelines are mandatory.
- Published
- 2019
30. Guía ESC 2015 sobre el tratamiento de la endocarditis infecciosa
- Author
-
Stefan Agewall, Isidre Vilacosta, Raluca Elena Dulgheru, Edyta Plonska-Gosciniak, Manuel J. Antunes, Sigrun Halvorsen, Franck Thuny, Bernard Cosyns, Ulrika Snygg-Martin, Scipione Carerj, Kaat Siebens, Çetin Erol, José Luis Zamorano, Petros Nihoyannopoulos, Werner Benzer, Carlos A. Mestres, Mitja Lainscak, Raphael Rosenhek, Erwan Donal, Gregory Y.H. Lip, Massimo F Piepoli, Barbara J. Mulder, Konstantinos Dimopoulos, Paulus Kirchhof, Maria Grazia Bongiorni, David M. Walker, Paola Anna Erba, Pilar Tornos Mas, Michele De Bonis, Heinz Drexel, Frank A. Flachskampf, Jolien W. Roos-Hesselink, George Athanassopoulos, Bruno Hoen, Saide Aytekin, Victor Aboyans, Adelino F. Leite-Moreira, José M. Miró, Héctor Bueno, Julie De Backer, Roger Hall, Bernard Iung, Jean Paul Casalta, Prakash P Punjabi, Claudio Rapezzi, Susanna Price, Lidewij Broekhuizen, Gebrine El Khoury, Francesco Del Zotti, Patrizio Lancellotti, Juan Tamargo, Gilbert Habib, Habib, G., Lancellotti, P., Antunes, M. J., Bongiorni, M. G., Casalta, J. -P., Zotti, F. D., Dulgheru, R., Khoury, G. E., Erba, P. A., Iung, B., Miro, J. M., Mulder, B. J., Plonska-Gosciniak, E., Price, S., Roos-Hesselink, J., Snygg-Martin, U., Thuny, F., Mas, P. T., Vilacosta, I., Zamorano, J. L., Erol, C., Nihoyannopoulos, P., Aboyans, V., Agewall, S., Athanassopoulos, G., Aytekin, S., Benzer, W., Bueno, H., Broekhuizen, L., Carerj, S., Cosyns, B., De Backer, J., De Bonis, M., Dimopoulos, K., Donal, E., Drexel, H., Flachskampf, F. A., Hall, R., Halvorsen, S., Hoen, B., Kirchhof, P., Lainscak, M., Leite-Moreira, A. F., Lip, G. Y. H., Mestres, C. A., Piepoli, M. F., Punjabi, P. P., Rapezzi, C., Rosenhek, R., Siebens, K., Tamargo, J., Walker, D. M., Habib, Gilbert, Lancellotti, Patrizio, Antunes, Manuel J., Bongiorni, Maria Grazia, Casalta, Jean-Paul, Zotti, Francesco Del, Dulgheru, Raluca, Khoury, Gebrine El, Erba, Paola Anna, Iung, Bernard, Miró, Jose M., Mulder, Barbara J., Plonska-Gosciniak, Edyta, Price, Susanna, Roos-Hesselink, Jolien, Snygg-Martin, Ulrika, Thuny, Franck, Mas, Pilar Torno, Vilacosta, Isidre, Zamorano, José Lui, Erol, Çetin, Nihoyannopoulos, Petro, Aboyans, Victor, Agewall, Stefan, Athanassopoulos, George, Aytekin, Saide, Benzer, Werner, Bueno, Héctor, Broekhuizen, Lidewij, Carerj, Scipione, Cosyns, Bernard, De Backer, Julie, De Bonis, Michele, Dimopoulos, Konstantino, Donal, Erwan, Drexel, Heinz, Flachskampf, Frank Arnold, Hall, Roger, Halvorsen, Sigrun, Hoen, Bruno, Kirchhof, Paulu, Lainscak, Mitja, Leite-Moreira, Adelino F., Lip, Gregory Y.H., Mestres, Carlos A., Piepoli, Massimo F., Punjabi, Prakash P., Rapezzi, Claudio, Rosenhek, Raphael, Siebens, Kaat, Tamargo, Juan, and Walker, David M.
- Subjects
business.industry ,practice guideline ,Endocarditis. Imagen cardiaca. Valvulopatía. Ecocardiografía. Pronóstico. Guías de práctica clínica. Infección. Imagen de cardiología nuclear. Cirugía cardiaca. Dispositivo cardiaco. Válvulas cardiacas protésicas. Cardiopatía congénita. Embarazo. Profilaxis. Prevención ,Cardiology and Cardiovascular Medicine ,bacterial endocarditis ,Settore MED/11 - Malattie dell'Apparato Cardiovascolare ,030204 cardiovascular system & hematology ,NO ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,business ,Humanities - Abstract
Las Guías de Práctica Clínica (GPC) tienen como objetivo reunir y evaluar toda la evidencia relevante disponible durante el proceso deelaboración sobre un tema particular para ayudar a los médicos a seleccionar la mejor estrategia posible de tratamiento para un paciente en particular, que sufre una enfermedad determinada, teniendo en cuenta no solo el resultado final, sino también sopesando los riesgos y los beneficios de un procedimiento diagnóstico o terapéutico concreto. Las GPC y las recomendaciones deben ayudar a los profesionales de la salud en la toma de decisiones clínicas en su ejercicio diario. No obstante, la decisión final sobre un paciente concreto la debe tomar el médico responsable de su cuidado, en consulta con el propio paciente o, cuando proceda, con la persona responsable de sus cuidados. En los últimos años, la Sociedad Europea de Cardiología (ESC), además de otras sociedades y organizaciones científicas, ha publicado un gran número de GPC. Debido al impacto de las GPC, se han establecido criterios de calidad para su elaboración de forma que todas las decisiones se presenten de modo claro y transparente al usuario. Se puede encontrar las recomendaciones de la ESC para la elaboración y publicación de GPC en la sección de guías de la página web de la ESC (http://www.escardio.org/Guidelines-&-Education/Clinical-Practice- Guidelines/Guidelines-development/Writing-ESC-Guidelines). Las GPC de la ESC representan la postura oficial de la ESC sobre un tema particular y se actualizan con regularidad.
- Published
- 2016
31. 2015 ESC Guidelines for the management of infective endocarditis
- Author
-
Habib, Gilbert, Lancellotti, Patrizio, Antunes, Manuel J., Bongiorni, Maria Grazia, Casalta, Jean-Paul, del Zotti, Francesco, Dulgheru, Raluca, El Khoury, Gebrine, Erba, Paola Anna, Iung, Bernard, Miro, Jose M., Mulder, Barbara J., Plonska-Gosciniak, Edyta, Price, Susanna, Roos-Hesselink, Jolien, Snygg-Martin, Ulrika, Thuny, Franck, Tornos Mas, Pilar, Vilacosta, Isidre, Zamorano, Jose Luis, Erol, Çetin, Nihoyannopoulos, Petros, Aboyans, Victor, Agewall, Stefan, Athanassopoulos, George, Aytekin, Saide, Benzer, Werner, Bueno, Héctor, Broekhuizen, Lidewij, Carerj, Scipione, Cosyns, Bernard, de Backer, Julie, de Bonis, Michele, Dimopoulos, Konstantinos, Donal, Erwan, Drexel, Heinz, Flachskampf, Frank Arnold, Hall, Roger, Halvorsen, Sigrun, Hoen, Bruno, Kirchhof, Paulus, Lainscak, Mitja, Leite-Moreira, Adelino F., Lip, Gregory Y. H., Mestres, Carlos A., Piepoli, Massimo F., Punjabi, Prakash P., Rapezzi, Claudio, Rosenhek, Raphael, Siebens, Kaat, Tamargo, Juan, Walker, David M., Habib, G, Lancellotti, P, Antunes, M, Bongiorni, M, Casalta, J, Del Zotti, F, Dulgheru, R, El Khoury, G, Erba, P, Iung, B, Mirob, J, Mulder, B, Plonska-Gosciniak, E, Price, S, Roos-Hesselink, J, Snygg-Martin, U, Thuny, F, Mas, P, Vilacosta, I, Zamorano, J, Erol, C, Nihoyannopoulos, P, Aboyans, V, Agewall, S, Athanassopoulos, G, Aytekin, S, Benzer, W, Bueno, H, Broekhuizen, L, Carerj, S, Cosyns, B, De Backer, J, De Bonis, M, Dimopoulos, K, Donal, E, Drexel, H, Flachskampf, F, Hall, R, Halvorsen, S, Hoenb, B, Kirchhof, P, Lainscak, M, Leite-Moreira, A, Lip, G, Mestresc, C, Piepoli, M, Punjabi, P, Rapezzi, C, Rosenhek, R, Siebens, K, Tamargo, J, Walker, D, ACS - Amsterdam Cardiovascular Sciences, and Cardiology
- Subjects
Microbiological Techniques ,Embolism ,Heart Valve Diseases ,Guideline ,Arrhythmias ,Cardiovascular ,Congenital ,Postoperative Complications ,Pregnancy ,Recurrence ,Risk Factors ,Neoplasms ,Ambulatory Care ,Non-Infective ,Pericarditis ,Endocarditi ,Musculoskeletal Diseases ,Prophylaxi ,Heart Defects ,Cross Infection ,Endocarditis ,Thoracic Surgery ,Cardiac surgery ,Acute Kidney Injury ,Prognosis ,Operative ,Anti-Bacterial Agents ,Myocarditis ,Prosthetic heart valve ,Echocardiography ,Female ,Infection ,Cardiology and Cardiovascular Medicine ,Nuclear imaging ,Infected ,Cardiac ,Diagnostic Imaging ,Prosthesis-Related Infections ,Critical Care ,Prognosi ,Guidelines ,Prosthetic heart valves ,Cardiac device ,Risk Assessment ,Valve disease ,Cardiac imaging ,Congenital heart disease ,Prevention ,Prophylaxis ,Aneurysm, Infected ,Antibiotic Prophylaxis ,Arrhythmias, Cardiac ,Clinical Laboratory Techniques ,Dentistry, Operative ,Endocarditis, Non-Infective ,Fibrinolytic Agents ,Heart Defects, Congenital ,Heart Failure ,Humans ,Long-Term Care ,Nervous System Diseases ,Patient Care Team ,Pregnancy Complications, Cardiovascular ,Splenic Diseases ,Thoracic Surgical Procedures ,Endocarditis, Bacterial ,Aneurysm ,Pregnancy Complications ,Dentistry - Abstract
Take-home message of the full 2015 ESC Guidelines, also endorsed by the European Association for Cardio-Thoracic Surgery, European Association of Nuclear Medicine, and European Society of Clinical Microbiology and Infectious Diseases.
- Published
- 2015
32. Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study
- Author
-
Murdoch , David R, Corey , G Ralph, Hoen , Bruno, Miró , José M, Fowler , Vance G, Bayer , Arnold S, Karchmer , Adolf W, Olaison , Lars, Pappas , Paul A, Moreillon , Philippe, Chambers , Stephen T, Chu , Vivian H, Falcó , Vicenç, Holland , David J, Jones , Philip, Klein , John L, Raymond , Nigel J, Read , Kerry M, Tripodi , Marie Francoise, Utili , Riccardo, Wang , Andrew, Woods , Christopher W, Cabell , Christopher H, Renseigné , Non, International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators, Gordon, D., Devi, U., Spelman, D., van der Meer, J.T., Kauffman, C., Bradley, S., Armstrong, W., Giannitsioti, E., Giamarellou, H., Lerakis, S., del Rio, A., Moreno, A., Mestres, C.A., Ninot, C.A., Pare, C., de la Maria, C.G., Armero, Y., de Lazzari, E., Marco, F., Gatell, J.M., Almela, M., Azqueta, M., Sitges, M., Claramonte, X., Jiménez-Expósito, M.J., de Benito, N., Ramirez, J., Perez, N., Miro, J.M., Almirante, B., Fernandez-Hidalgo, N., de Vera, P.R., Tornos, P., Falco, V., Sidani, N., Kanj-Sharara, S., Kanafani, Z., Raglio, A., Goglio, A., Gnecchi, F., Suter, F., Valsecchi, G., Rizzi, M., Ravasio, V., Hoen, B., Chirouze, C., Leroy, J., Plesiat, P., Bernard, Y., Casey, A., Lambert, P., Watkin, R., Elliott, T., Patel, M., Dismukes, W., Pan, A., Caros, G., Mathiron, A.B., Tribouilloy, C., Goissen, T., Delahaye, A., Delahaye, F., Vandenesch, F., Vizzotti, C., Nacinovich, F.M., Marin, M., Trivi, M., Lombardero, M., Cortes, C., Casabé, J.H., Altclas, J., Kogan, S., Clara, L., Sanchez, M., Commerford, A., Hansa, C., Deetlefs, E., Ntsekhe, M., Commerford, P., Wray, D., Steed, L.L., Church, P., Cantey, R., Morris, A., Holland, D.J., Murdoch, D.R., Chambers, S.T., Read, K.M., Raymond, N.J., Lang, S., Kotsanas, D., Korman, T.M., Peterson, G., Purcell, J., Southern, P.M., Shah, M., Bedimo, R., Reddy, A., Levine, D., Dhar, G., Hanlon-Feeney, A., Hannan, M., Kelly, S., Wang, A., Cabell, C.H., Woods, C.W., Sexton, D.J., Benjamin, D.J., McDonald, J.R., Federspiel, J., Engemann, J.J., Reller, B., Drew, L., Caram, L.B., Stryjewski, M., Morpeth, S., Lalani, T., Fowler, V.G., Chu, V.H., Mazaheri, B., Neuerburg, C., Naber, C., Athan, E., Henry, M., Harris, O., Alestig, E., Olaison, L., Wikstrom, L., Snygg-Martin, U., Francis, J., Venugopal, K., Nair, L., Thomas, V., Chaiworramukkun, J., Pachirat, O., Chetchotisakd, P., Suwanich, T., Kamarulzaman, A., Tamin, S.S., Premru, M.M., Logar, M., Lejko-Zupanc, T., Orezzi, C., Klein, J.L., Bouz, E., Rodríguez-Créixems, M., Marín, M., Fernández, M., Muñoz, P., Fernández, R., Ramallo, V., Raoult, D., Thuny, F., Habib, G., Casalta, J.P., Fournier, P.E., Chipigina, N., Kirill, O., Vinogradova, T., Kulichenko, V.P., Butkevich, O.M., Lion, C., Selton-Suty, C., Coyard, H., Doco-Lecompte, T., Iarussi, D., Durante-Mangoni, E., Ragone, E., Dialetto, G., Tripodi, M.F., Utili, R., Casillo, R., Kumar, A.S., Sharma, G., Dickerman, S.A., Street, A., Eisen, D.P., McBryde, E.S., Grigg, L., Abrutyn, E., Michelet, C., Tattevin, P., Donnio, P.Y., Fortes, C.Q., Edathodu, J., Al-Hegelan, M., Font, B., Anguera, I., Guma, J.R., Cereceda, M., Oyonarte, M.J., Mella, R.M., Garcia, P., Jones, S.B., Ramos, A.I., Paiva, M.G., Tranchesi, R.A., Woon, L.L., Lum, L.N., Tan, R.S., Rees, D., Kornecny, P., Lawrence, R., Dever, R., Post, J., Jones, P., Ryan, S., Harkness, J., Feneley, M., Rubinstein, E., Strahilewitz, J., Ionac, A., Mornos, C., Dragulescu, S., Forno, D., Cecchi, E., De Rosa, F., Imazio, M., Trinchero, R., Wiesbauer, F., Gattringer, R., Deans, G., Andrasevic, A.T., Barsic, B., Klinar, I., Vincelj, J., Bukovski, S., Krajinovic, V., Stafford, J., Baloch, K., Pappas, P.A., Redick, T., Harding, T., Karchmer, A.W., Bayer, A.S., Corey, R., Moreillon, P., Durack, D.T., Eykyn, S., Service des maladies infectieuses et tropicales, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Saint-Jacques, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Hôpital Saint-Jacques, Murdoch, D., Corey, G., Miro', J., Fowler, V. J., Bayer, A., Karchmer, A., Pappas, P., Chambers, S., Chu, V., Falco', V., Holland, D., Klein, J., Raymond, N., Read, K., Tripodi, M. F., Utili, Riccardo, Woods, C., Cabell, C., AII - Amsterdam institute for Infection and Immunity, Infectious diseases, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)
- Subjects
Male ,MESH: Endocarditis ,MESH : Aged ,MESH : Prospective Studies ,030204 cardiovascular system & hematology ,endocarditi ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Mitral valve ,MESH: Staphylococcus aureus ,MESH : Female ,Prospective Studies ,Prospective cohort study ,Abscess ,MESH: Aged ,Adult ,Aged ,Endocarditis/microbiology ,Endocarditis/mortality ,Endocarditis/therapy ,Female ,Humans ,Middle Aged ,Staphylococcal Infections/microbiology ,Staphylococcus aureus/isolation & purification ,endocarditis ,hospital mortality ,0303 health sciences ,MESH: Middle Aged ,Endocarditis ,MESH : Staphylococcus aureus ,Staphylococcal Infections ,MESH : Adult ,MESH : Endocarditis ,3. Good health ,[ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,medicine.anatomical_structure ,Infective endocarditis ,epidemiology ,Staphylococcus aureus ,medicine.medical_specialty ,complications ,MESH : Male ,MESH: Staphylococcal Infections ,Staphylococcal infections ,Article ,03 medical and health sciences ,Endocarditis, clinical presentattion, S. aureus ,Internal medicine ,Internal Medicine ,medicine ,MESH : Middle Aged ,staphylococci ,MESH: Humans ,030306 microbiology ,business.industry ,clinical presentattion ,MESH : Humans ,MESH: Adult ,Odds ratio ,S. aureus ,medicine.disease ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,MESH: Male ,MESH: Prospective Studies ,Surgery ,Etiology ,MESH : Staphylococcal Infections ,business ,MESH: Female - Abstract
International audience; BACKGROUND: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. METHODS: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. RESULTS: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (
- Published
- 2009
33. Trends in Enterococcus faecium Bacteremia: Exploring Risk Factors with Emphasis on Prior Antibiotic Exposure.
- Author
-
Sörstedt E, Ahlbeck G, and Snygg-Martin U
- Abstract
Enterococcal bacteremia (EB) is on the rise both in Sweden and globally. While Enterococcus faecalis ( E. faecalis ) is susceptible to ampicillin and piperacillin/tazobactam (pip/taz), Enterococcus faecium ( E. faecium ) is not. Historically, most enterococcal infections have been caused by E. faecalis, but the epidemiology is changing with increasing recognition of enterococci as nosocomial pathogens and the emergence of resistance to commonly used antimicrobial agents. The use of pip/taz has increased dramatically in Sweden, but it is unknown if this has affected the relative incidence of E. faecalis/E. faecium bacteremia. Here, we investigate whether the number and proportion of E. faecium bacteremia (EfmB) cases have increased. Additionally, risk factors associated with EfmB with a focus on prior antibiotic exposure are analyzed. Medical journals of 360 patients with EB admitted to Sahlgrenska University Hospital are reviewed. The proportion of EfmB cases increased from 41% in 2015 to 51% in 2021. Hospital-acquired infection, previous exposure to pip/taz, and carbapenems are identified as independent risk factors for EfmB. There are considerable patient-related differences between the EfmB and EfsB groups, but there is no difference in mortality rates. In conclusion, the increasing proportion of EfmB cases is concerning and is seen parallel to the expanding use of pip/taz, one possible contributing factor. Our findings suggest that a cautious approach to antibiotic use is essential to prevent the spread of antibiotic-resistant bacteria.
- Published
- 2024
- Full Text
- View/download PDF
34. Consequences of Excluding Enterococcus faecium as a Typical Endocarditis Pathogen in the Duke-ISCVID Criteria: Endocarditis Is Endocarditis Even if the Bacterium Is Uncommon.
- Author
-
Lindberg H, Snygg-Martin U, Berge A, and Rasmussen M
- Subjects
- Humans, Enterococcus faecium, Endocarditis, Endocarditis, Bacterial diagnosis, Endocarditis, Bacterial microbiology
- Abstract
Competing Interests: Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
- Published
- 2023
- Full Text
- View/download PDF
35. Cumulative Incidence of Infective Endocarditis in Patients with Congenital Heart Disease: A Nationwide, Case-Control Study Over Nine Decades.
- Author
-
Snygg-Martin U, Giang KW, Dellborg M, Robertson J, and Mandalenakis Z
- Subjects
- Adolescent, Adult, Aged, 80 and over, Case-Control Studies, Child, Female, Humans, Incidence, Risk Factors, Endocarditis complications, Endocarditis epidemiology, Endocarditis, Bacterial epidemiology, Heart Defects, Congenital complications, Heart Defects, Congenital epidemiology
- Abstract
Background: Congenital heart disease (CHD) is a lifelong predisposing condition for infective endocarditis (IE). As a consequence of advances in pediatric care, the number of adults with CHD is now exceeding the number of children. The goal of the present study was to determine the cumulative incidence of IE in patients with CHD and detect temporal changes compared with controls., Methods: Nationwide registry-based case-control study of patients with CHD born 1930-2017 matched with 10 random controls. Infective endocarditis episodes were linked using the Swedish 10-digit personal identification number., Results: In total, 89 541 patients with CHD and 890 470 matched controls were included. In patients with CHD, 1477 IE episodes were registered and 447 episodes in controls. Patients with CHD had 8.5% cumulative incidence of IE at age 87 years, compared with 0.7% in matched controls. Incidence rate of IE per 100 000 person-years was 65.5 (95% confidence interval [CI] 62.2-68.9) and 1.8 (95% CI: 1.7-2.0) in CHD patients and controls, respectively. By age 18 years, patients with CHD had an IE incidence similar to that of 81-year-old controls. Incidence of IE differed by age but not by birth year. Bacterial etiology was registered from 1997 in half of the IE episodes; among CHD IE cases, 43.3% were caused by streptococci and 29.8% by Staphylococcus aureus., Conclusions: Infective endocarditis remains an important complication in patients with CHD. Incidence correlate with age and the number of IE episodes are expected to increase as the CHD population grow older., (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)
- Published
- 2021
- Full Text
- View/download PDF
36. [Q fever endocarditis - a rare condition with high mortality].
- Author
-
Louca A, Shahnavaz A, Florin Ljungkvist J, Snygg-Martin U, and Tygesen H
- Subjects
- Animals, Cattle, Female, Humans, Pregnancy, Sheep, Coxiella burnetii, Endocarditis, Endocarditis, Bacterial diagnosis, Endocarditis, Bacterial drug therapy, Heart Valve Diseases, Q Fever complications, Q Fever diagnosis, Q Fever drug therapy
- Abstract
Coxiella burnetii is the causative agent of Q fever. It can manifest in both acute and chronic forms. Culture-negative endocarditis is the most common and serious presenting form of chronic Q fever. This occurs almost exclusively in patients with a pre-existing valvulopathy including valve prosthesis or immunocompromised patients as well as in pregnant women. Diagnosis is often delayed or missed due to the nonspecific symptoms of the condition. Without the proper antimicrobial therapy, the mortality is high. Q fever endocarditis should be suspected especially in people who recently had acute Q fever, people who come from endemic areas as well as people with occupational contact with sheep, goats and cattle and endocarditis symptoms. In this article we present a case with a patient who died of unknown cause and where PCR performed on autopsy of the valve revealed Q fever endocarditis.
- Published
- 2021
37. Does extraction of cardiac implantable electronic devices improve outcome in patients with Staphylococcus aureus bacteraemia?
- Author
-
Snygg-Martin U, Ruus C, Skovbjerg S, Studahl M, and Andersson LM
- Subjects
- Electronics, Humans, Retrospective Studies, Staphylococcus aureus, Bacteremia, Staphylococcal Infections epidemiology, Staphylococcal Infections therapy
- Abstract
Background: Staphylococcus aureus bacteraemia (SAB) is recognized as an infection that is difficult to treat and with high risk of device related infection. Extraction/explantation of cardiac implantable electronic devices (CIED) is recommended in SAB patients but studies evaluating long-term prognosis are scarce., Materials and Methods: In this retrospective cohort study, 626 consecutive SAB patients were identified in routine diagnostics (November 2014-October 2016). Patient characteristic, infective endocarditis (IE) incidence and mortality were compared for patients with and without CIED., Results: SAB patients with CIED ( n = 33) compared to non-CIED patients ( n = 593) were older (83 versus 70 years, p = .0001), had a higher 30-day mortality (12/33, 36% versus 119/593, 20%, p = .044) and higher incidence of IE (9/33, 27% versus 41/593, 7%, p = .0006). One-year mortality was 19/33 (58%) among the SAB CIED patients. Echocardiography was performed in all nine patients with CIED-IE but only in 14/24 (58%) of the 24 SAB CIED patients that were considered not having IE. However, if patients with very early mortality were excluded, echocardiography was performed in 14/17 (82%) of SAB CIED-non-IE patients. CIED extraction/explantation during intravenous antibiotic treatment was only performed in three patients with SAB CIED-IE and in one non-IE patient. One year post treatment initiation, 14 out of 33 SAB CIED patients were alive of whom only one had CIED extraction/explantation performed as part of treatment., Conclusion: Staphylococcus aureus bacteraemia in CIED patients is associated with poor prognosis but in a subgroup of patients survival beyond one year was seen despite retainment of the electronic device.
- Published
- 2020
- Full Text
- View/download PDF
38. [The virtual ward - the students' clinical education during the current pandemic].
- Author
-
Robertson J, Ahlgren E, Rydberg F, Snygg-Martin U, Westin J, and Studahl M
- Subjects
- Betacoronavirus, COVID-19, Humans, SARS-CoV-2, Sweden, Universities, Coronavirus Infections, Education, Distance, Education, Medical methods, Pandemics, Pneumonia, Viral, Students, Medical
- Abstract
On March 17, 2020, the Swedish Government recommended all higher education institutions to move to online and distance learning during the COVID-19 pandemic. The integrated course in Infection, Microbiology, and Immunity at the Programme in Medicine at University of Gothenburg had to be completely transformed. Creative solutions have now replaced the clinical training that normally takes place during the students' clinical education at the hospital. We developed a digital concept entitled "the virtual ward", in which we interact with the students in real time. Here, the students are able to follow their patients on a daily basis during teacher-guided sessions.
- Published
- 2020
39. European Heart Rhythm Association (EHRA) international consensus document on how to prevent, diagnose, and treat cardiac implantable electronic device infections-endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS), International Society for Cardiovascular Infectious Diseases (ISCVID), and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS).
- Author
-
Blomström-Lundqvist C, Traykov V, Erba PA, Burri H, Nielsen JC, Bongiorni MG, Poole J, Boriani G, Costa R, Deharo JC, Epstein LM, Sághy L, Snygg-Martin U, Starck C, Tascini C, and Strathmore N
- Subjects
- Asia, Consensus, Electronics, Humans, Latin America, Communicable Diseases, Defibrillators, Implantable adverse effects, Thoracic Surgery
- Abstract
Pacemakers, implantable cardiac defibrillators, and cardiac resynchronization therapy devices are potentially lifesaving treatments for a number of cardiac conditions but are not without risk. Most concerning is the risk of a cardiac implantable electronic device (CIED) infection, which is associated with significant morbidity, increased hospitalizations, reduced survival, and increased health care costs. Recommended preventive strategies such as administration of intravenous antibiotics before implantation are well-recognized. Uncertainties have remained about the role of various preventive, diagnostic, and treatment measures such as skin antiseptics, pocket antibiotic solutions, antibacterial envelopes, prolonged antibiotics post-implantation, and others. When compared with previous guidelines or consensus statements, the present consensus document gives guidance on the use of novel device alternatives, novel oral anticoagulants, antibacterial envelopes, prolonged antibiotics post-implantation, as well as definitions on minimum quality requirements for centres and operators and volumes. The recognition that an international consensus document focused on management of CIED infections is lacking, the dissemination of results from new important randomized trials focusing on prevention of CIED infections, and observed divergences in managing device-related infections as found in an European Heart Rhythm Association worldwide survey, provided a strong incentive for a Novel 2019 International State-of-the-art Consensus document on risk assessment, prevention, diagnosis, and treatment of CIED infections., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2020
- Full Text
- View/download PDF
40. Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort.
- Author
-
Fernández Hidalgo N, Gharamti AA, Aznar ML, Almirante B, Yasmin M, Fortes CQ, Plesiat P, Doco-Lecompte T, Rizk H, Wray D, Lamas C, Durante-Mangoni E, Tattevin P, Snygg-Martin U, Hannan MM, Chu VH, and Kanafani ZA
- Abstract
Background: Beta-hemolytic streptococci (BHS) are an uncommon cause of infective endocarditis (IE). The aim of this study was to describe the clinical features and outcomes of patients with BHS IE in a large multinational cohort and compare them with patients with viridans streptococcal IE., Methods: The International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) is a large multinational database that recruited patients with IE prospectively using a standardized data set. Sixty-four sites in 28 countries reported patients prospectively using a standard case report form developed by ICE collaborators., Results: Among 1336 definite cases of streptococcal IE, 823 were caused by VGS and 147 by BHS. Patients with BHS IE had a lower prevalence of native valve ( P < .005) and congenital heart disease predisposition ( P = .002), but higher prevalence of implantable cardiac device predisposition ( P < .005). Clinically, they were more likely to present acutely ( P < .005) and with fever ( P = .024). BHS IE was more likely to be complicated by stroke and other systemic emboli ( P < .005). The overall in-hospital mortality of BHS IE was significantly higher than that of VGS IE ( P = .001). In univariate analysis, variables associated with in-hospital mortality for BHS IE were age (odds ratio [OR], 1.044; P = .004), prosthetic valve IE (OR, 3.029; P = .022), congestive heart failure (OR, 2.513; P = .034), and stroke (OR, 3.198; P = .009)., Conclusions: BHS IE is characterized by an acute presentation and higher rate of stroke, systemic emboli, and in-hospital mortality than VGS IE. Implantable cardiac devices as a predisposing factor were more often found in BHS IE compared with VGS IE., (© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
- Published
- 2020
- Full Text
- View/download PDF
41. Clinical practice and implementation of guidelines for the prevention, diagnosis and management of cardiac implantable electronic device infections: results of a worldwide survey under the auspices of the European Heart Rhythm Association.
- Author
-
Traykov V, Bongiorni MG, Boriani G, Burri H, Costa R, Dagres N, Deharo JC, Epstein LM, Erba PA, Snygg-Martin U, Nielsen JC, Poole JE, Saghy L, Starck C, Strathmore N, and Blomström-Lundqvist C
- Subjects
- Antibiotic Prophylaxis methods, Antibiotic Prophylaxis statistics & numerical data, Arrhythmias, Cardiac therapy, Global Health statistics & numerical data, Heart Diseases therapy, Humans, Practice Guidelines as Topic, Practice Patterns, Physicians', Prosthesis Implantation methods, Surveys and Questionnaires, Anti-Bacterial Agents classification, Anti-Bacterial Agents therapeutic use, Cardiac Resynchronization Therapy Devices adverse effects, Clinical Protocols standards, Defibrillators, Implantable adverse effects, Patient Care Management methods, Patient Care Management standards, Prosthesis Implantation adverse effects, Prosthesis-Related Infections diagnosis, Prosthesis-Related Infections etiology, Prosthesis-Related Infections prevention & control, Secondary Prevention methods, Secondary Prevention standards
- Abstract
Aims: Cardiac implantable electronic device (CIED) infection rates are increasing. Worldwide compliance and disparities to published guidelines for the prevention, diagnosis and management of these conditions are not well elucidated. The purpose of this survey, therefore, was to clarify these issues through an inquiry to arrhythmia-related associations and societies worldwide., Methods and Results: A questionnaire comprising 15 questions related to CIED infections was distributed among members of seven arrhythmia societies worldwide. A total of 234 centres in 62 countries reported implantation rates of which 159 (68.0%) performed more than 200 device implantations per year and 14 (6.0%) performed fewer than 50 implantations per year. The reported rates of CIED infections for 2017 were ≤2% in 78.7% of the centres, while the infection rates exceeded 5% in 7.8% of the centres. Preventive measures for CIED infection differed from published recommendations and varied among different regions mainly in terms of pocket irrigation and administering post-operative antimicrobial therapy the use of which was reported by 39.9% and 44% of the respondents, respectively. Antibacterial envelopes were used by 37.7% of the respondents in selected circumstances. In terms of pocket infection management, 62% of the respondents applied complete system removal as an initial step. Diagnostic pocket needle aspiration and pocket surgical debridement were reported by 15.8% and 11.8% of centres, respectively., Conclusion: Clinical practices for prevention and management of CIED do not fully comply with current recommendations and demonstrate considerable regional disparities. Further education and programmes for improved implementation of guidelines are mandatory., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.)
- Published
- 2019
- Full Text
- View/download PDF
42. Tidig infektionskonsult gav effekt vid Staphylococcus aureus-bakteriemi - Konsultationen minskade återinläggningsfrekvens och mortalitet, visar retrospektiv studie.
- Author
-
Ruus C, Skovbjerg S, Magnusson T, Snygg-Martin U, Studahl M, and Andersson LM
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Bacteremia drug therapy, Child, Child, Preschool, Cloxacillin therapeutic use, Comorbidity, Female, Humans, Infant, Male, Middle Aged, Retrospective Studies, Staphylococcal Infections drug therapy, Staphylococcus aureus isolation & purification, Time Factors, Young Adult, Bacteremia mortality, Infection Control Practitioners, Patient Readmission statistics & numerical data, Staphylococcal Infections mortality
- Abstract
Automatic infectious disease consultant alert is associated with decreased mortality and readmission rate in Staphylococcus aureus bacteriemia A management plan was implemented at a 2000 bed teaching hospital where positive blood cultures with growth of Staphylococcus aureus were reported simultaneously to the ordering unit and to the Infectious Disease Consultant. Readmission rate and 30-day mortality were compared one year before and one year after introduction of the management plan. Out of totally 320 respectively 321 patients with SAB 252 and 244 were included in the study. 30-day mortality decreased from 26/252 (10%) to 14/244 (5,7%) (p=0.059) when all patients with SAB were included and to 9/193 (4,7%) (p=0,026) when only patients who received a formal consultation after introduction of the management plan were included. The rate of readmission within 30 days declined from 38/227 (17%) in 2014-2015 to 24/230 (10%) in 2015-2016 (p=0,049).
- Published
- 2018
43. Surgical decision-making in aortic prosthetic valve endocarditis: the influence of electrocardiogram-gated computed tomography.
- Author
-
Fagman E, Flinck A, Snygg-Martin U, Olaison L, Bech-Hanssen O, and Svensson G
- Subjects
- Aged, Aortic Valve diagnostic imaging, Echocardiography, Endocarditis, Bacterial diagnostic imaging, Endocarditis, Bacterial microbiology, Female, Humans, Male, Middle Aged, Preoperative Care methods, Prospective Studies, Aortic Valve surgery, Electrocardiography methods, Endocarditis, Bacterial surgery, Heart Valve Prosthesis Implantation methods, Tomography, X-Ray Computed methods
- Abstract
Objectives: The aim of this study was to investigate the value of electrocardiogram (ECG)-gated computed tomography (CT) in the surgical decision-making and preoperative evaluation in patients with aortic prosthetic valve endocarditis (PVE)., Methods: Sixty-eight prosthetic valves in 67 patients with aortic PVE were prospectively evaluated with ECG-gated CT and transoesophageal echocardiography (TEE). Imaging findings considered indications for surgery were as follows: (i) abscess/pseudoaneurysm formation; (ii) prosthetic valve dehiscence; (iii) valve destruction with valvular regurgitation; (iv) large vegetations (>1.5 cm). The coronary arteries were evaluated with ECG-gated CT. Clinical data including surgical reports and mortality data were collected., Results: Fifty-eight of 68 cases had indication for surgery based on imaging findings (ECG-gated CT/TEE). In 8 of these cases (14%), there was indication for surgery based on CT but not on TEE findings (all had perivalvular pseudoaneurysms). In 11 cases (19%), there was indication for surgery based on TEE but not on CT findings [non-drained abscess (n = 5), prosthetic valve dehiscence (n = 4), large vegetation (n = 1), valve destruction (n = 1)]. In 31 of 32 patients with indication for preoperative coronary angiography, ECG-gated CT coronary angiography was diagnostic. In 1 patient, ECG-gated CT coronary angiography was inconclusive and invasive coronary angiography was performed., Conclusions: In patients with aortic PVE, ECG-gated CT provides additional information over TEE regarding perivalvular extension of infection, which can influence surgical decision-making. Furthermore, ECG-gated CT provides a non-invasive coronary angiogram and can in most cases replace invasive coronary angiography in the preoperative evaluation., (© The Author 2016. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
44. 18F-FDG PET/CT in the diagnosis of prosthetic valve endocarditis.
- Author
-
Fagman E, van Essen M, Fredén Lindqvist J, Snygg-Martin U, Bech-Hanssen O, and Svensson G
- Subjects
- Aged, Aortic Valve diagnostic imaging, Aortic Valve microbiology, Area Under Curve, Endocarditis microbiology, Female, Humans, Male, Middle Aged, Observer Variation, Predictive Value of Tests, Prosthesis-Related Infections microbiology, ROC Curve, Reproducibility of Results, Retrospective Studies, Aortic Valve surgery, Contrast Media, Endocarditis diagnostic imaging, Fluorodeoxyglucose F18, Heart Valve Prosthesis adverse effects, Heart Valve Prosthesis Implantation adverse effects, Heart Valve Prosthesis Implantation instrumentation, Positron Emission Tomography Computed Tomography, Prosthesis-Related Infections diagnostic imaging
- Abstract
Recent studies have shown promising results using (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in the diagnosis of prosthetic valve endocarditis (PVE). However, previous studies did not include negative controls. The aim of this study was to compare (18)F-FDG-uptake around prosthetic aortic valves in patients with and without PVE and to determine the diagnostic performance of (18)F-FDG PET/CT in the diagnosis of PVE. (18)F-FDG PET/CT examinations in patients with a prosthetic aortic valve performed 2008-2014 were retrieved. Eight patients with a final diagnosis of definite PVE were included in the analysis of the diagnostic performance of (18)F-FDG PET/CT. Examinations performed on suspicion of malignancy in patients without PVE (n = 19) were used as negative controls. Visual and semi-quantitative analysis was performed. Maximal standardized uptake value (SUVmax) in the valve area was measured and SUVratio was calculated by dividing valve SUVmax by SUVmax in the descending aorta. The sensitivity was 75 %, specificity 84 %, positive likelihood ratio [LR(+)] 4.8 and negative likelihood ratio [LR(-)] 0.3 on visual analysis. Both SUVmax and SUVratio were significantly higher in PVE patients [5.8 (IQR 3.5-6.5) and 2.4 (IQR 1.7-3.0)] compared to non-PVE patients [3.2 (IQR 2.8-3.8) and 1.5 (IQR 1.3-1.6)] (p < 0.001). ROC-curve analysis of SUVratio yielded an area under the curve of 0.90 (95 % CI 0.74-1.0). (18)F-FDG-uptake around non-infected aortic prosthetic valves was low. The level of (18)F-FDG-uptake in the prosthetic valve area showed a good diagnostic performance in the diagnosis of PVE.
- Published
- 2016
- Full Text
- View/download PDF
45. [2015 ESC Guidelines for the management of infective endocarditis. The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC)].
- Author
-
Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, and Zamorano JL
- Subjects
- Algorithms, Decision Trees, Endocarditis, Bacterial complications, Endocarditis, Bacterial prevention & control, Heart Valve Diseases etiology, Heart Valve Diseases therapy, Humans, Prognosis, Endocarditis, Bacterial diagnosis, Endocarditis, Bacterial therapy
- Published
- 2016
- Full Text
- View/download PDF
46. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM).
- Author
-
Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, and Zamorano JL
- Subjects
- Acute Kidney Injury diagnosis, Acute Kidney Injury therapy, Ambulatory Care, Aneurysm, Infected diagnosis, Aneurysm, Infected therapy, Anti-Bacterial Agents therapeutic use, Antibiotic Prophylaxis, Arrhythmias, Cardiac diagnosis, Arrhythmias, Cardiac therapy, Clinical Laboratory Techniques, Critical Care, Cross Infection etiology, Dentistry, Operative, Diagnostic Imaging methods, Embolism diagnosis, Embolism therapy, Endocarditis diagnosis, Endocarditis, Non-Infective diagnosis, Endocarditis, Non-Infective therapy, Female, Fibrinolytic Agents therapeutic use, Heart Defects, Congenital, Heart Failure diagnosis, Heart Failure therapy, Heart Valve Diseases diagnosis, Heart Valve Diseases therapy, Humans, Long-Term Care, Microbiological Techniques, Musculoskeletal Diseases diagnosis, Musculoskeletal Diseases microbiology, Musculoskeletal Diseases therapy, Myocarditis diagnosis, Myocarditis therapy, Neoplasms complications, Nervous System Diseases diagnosis, Nervous System Diseases microbiology, Nervous System Diseases therapy, Patient Care Team, Pericarditis diagnosis, Pericarditis therapy, Postoperative Complications etiology, Postoperative Complications prevention & control, Pregnancy, Pregnancy Complications, Cardiovascular diagnosis, Pregnancy Complications, Cardiovascular therapy, Prognosis, Prosthesis-Related Infections diagnosis, Prosthesis-Related Infections therapy, Recurrence, Risk Assessment, Risk Factors, Splenic Diseases diagnosis, Splenic Diseases therapy, Thoracic Surgical Procedures, Endocarditis therapy
- Published
- 2015
- Full Text
- View/download PDF
47. [2015 ESC Guidelines for the management of infective endocarditis].
- Author
-
Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Płońska-Gościniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Mas PT, Vilacosta I, and Zamorano JL
- Subjects
- Cardiology, Disease Management, Endocarditis, Bacterial therapy, Europe, Female, Humans, Male, Pregnancy, Societies, Medical, Endocarditis therapy
- Published
- 2015
- Full Text
- View/download PDF
48. Cystatin C in a composite risk score for mortality in patients with infective endocarditis: a cohort study.
- Author
-
Bjurman C, Snygg-Martin U, Olaison L, Fu ML, and Hammarsten O
- Abstract
Objective: To develop a multimarker prognostic score for infective endocarditis (IE)., Design: Retrospective case-control., Setting: Secondary care. Single centre., Participants: 125 patients with definite IE., Primary Outcome Measures: 90-day and 5-year mortality., Results: Mean age was 62.7±17 years. The 90-day and 5-year mortality was 10.4% and 33.6%, respectively. CysC levels at admission and over 20% increases in CysC levels during 2 weeks of treatment were prognostic for 90-day and 5-year mortality independent of creatinine estimated glomerular filtration rate. In multivariate analyses, CysC (OR 5.42, 95% CI 1.90 to 15.5, p=0.002) and age (OR 1.06, 95% CI 1.02 to 1.10, p=0.002) remained prognostic for 5-year mortality. NT-proBNP, TnT, C reactive protein and interleukin 6 were also linked to prognosis. A composite risk scoring system using levels of CysC, NT-proBNP, age and presence of mitral valve insufficiency was able to separate a high-risk and a low-risk group., Conclusions: CysC levels at admission and increase in CysC after 2 weeks of treatment were independent prognostic markers for both 90-day and 5-year mortality in patients with IE. A multimarker composite risk scoring system including CysC identified a high-risk group.
- Published
- 2012
- Full Text
- View/download PDF
49. The relationship between cerebrovascular complications and previously established use of antiplatelet therapy in left-sided infective endocarditis.
- Author
-
Snygg-Martin U, Rasmussen RV, Hassager C, Bruun NE, Andersson R, and Olaison L
- Subjects
- Aged, Aged, 80 and over, Cohort Studies, Denmark, Female, Humans, Incidence, Male, Middle Aged, Models, Statistical, Prospective Studies, Sweden, Endocarditis complications, Endocarditis drug therapy, Platelet Aggregation Inhibitors administration & dosage, Stroke epidemiology, Stroke mortality
- Abstract
Background: Cerebrovascular complications (CVC) in infective endocarditis (IE) are common. The only established treatments to reduce the incidence of CVC in IE are antibiotics and in selected cases early cardiac surgery. Potential effects of previously established antiplatelet therapy are under debate., Methods: In a prospective cohort study in Sweden and Demark, the influence of previously established antiplatelet therapy on CVC incidence and mortality in IE was assessed using logistic regression models., Results: Among 684 left-sided definite IE episodes, 23.0% were seen in patients on established antiplatelet therapy (96% acetylsalicylic acid). Patients on antiplatelet therapy were older and significantly more often had a history of congestive heart failure prior to IE diagnosis. No difference in CVC rate was seen between patients with and without ongoing antiplatelet therapy (23.6% vs 25.0%, adjusted odds ratio (AOR) 0.8, 95% confidence interval (CI) 0.48-1.5). Ischemic stroke, which occurred in 115 episodes (16.8%), was the most common cerebral lesion, and haemorrhagic complications were seen in 16 (2.3%) patients without correlation to chronic antiplatelet therapy. Unadjusted 1-y mortality was higher for patients on previously established antiplatelet therapy (33.8% vs 24.1%, odds ratio (OR) 1.6, 95% CI 1.1-2.4), but after adjustment for covariables associated with mortality an opposite statistical trend was seen (AOR 0.7, 95% CI 0.4-1.1)., Conclusions: The incidence of symptomatic CVC in IE patients was not reduced by previously established antiplatelet therapy. One-y mortality was higher in patients on antiplatelet therapy in univariate analysis, but after multivariable modelling this association was lost.
- Published
- 2011
- Full Text
- View/download PDF
50. One-year mortality in coagulase-negative Staphylococcus and Staphylococcus aureus infective endocarditis.
- Author
-
Rasmussen RV, Snygg-Martin U, Olaison L, Andersson R, Buchholtz K, Larsen CT, Hansen TF, Køber L, Hassager C, and Bruun NE
- Subjects
- Aged, Coagulase, Denmark epidemiology, Endocarditis, Bacterial microbiology, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Prospective Studies, Staphylococcal Infections microbiology, Staphylococcus aureus isolation & purification, Statistics, Nonparametric, Endocarditis, Bacterial mortality, Staphylococcal Infections mortality, Staphylococcus isolation & purification
- Abstract
The aim of this study was to investigate in-hospital mortality and 12-month mortality in patients with coagulase-negative Staphylococcus (CoNS) compared to Staphylococcus aureus (S. aureus) infective endocarditis (IE). We used a prospective cohort study of 66 consecutive CoNS and 170 S. aureus IE patients, collected at 2 tertiary university hospitals in Copenhagen (Denmark) and at 1 tertiary university hospital in Gothenburg (Sweden). Median (range) C-reactive protein at admission was higher in patients with S. aureus IE (150 mg/l (1-521) vs 94 mg/l (6-303); p<0.001), which may suggest a more serous infection. CoNS was associated with prosthetic valve IE (49% vs 24%; p<0.001) and median diagnostic delay was longer in CoNS IE patients (20 d (0-232) vs 9 d (0-132); p<0.001). In-hospital mortality was equally high in both groups but 25% of the CoNS IE patients had died after 1 y compared to 39% of patients with S. aureus IE (p =0.05). In conclusion, CoNS IE was associated with a long diagnostic delay and high in-hospital mortality, whereas post-discharge prognosis was better in this group of patients compared to patients with IE due to S. aureus.
- Published
- 2009
- Full Text
- View/download PDF
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.