493 results on '"Snyers, An"'
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2. CX-5461 causes nucleolar compaction, alteration of peri- and intranucleolar chromatin arrangement, an increase in both heterochromatin and DNA damage response
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Luc Snyers, Sylvia Laffer, Renate Löhnert, Klara Weipoltshammer, and Christian Schöfer
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Medicine ,Science - Abstract
Abstract In this study, we characterize the changes in nucleolar morphology and its dynamics induced by the recently introduced compound CX-5461, an inhibitor of ribosome synthesis. Time-lapse imaging, immunofluorescence and ultrastructural analysis revealed that exposure of cells to CX-5461 has a profound impact on their nucleolar morphology and function: nucleoli acquired a compact, spherical shape and display enlarged, ring-like masses of perinucleolar condensed chromatin. Tunnels consisting of chromatin developed as transient structures running through nucleoli. Nucleolar components involved in rRNA transcription, fibrillar centres and dense fibrillar component with their major constituents ribosomal DNA, RNA polymerase I and fibrillarin maintain their topological arrangement but become reduced in number and move towards the nucleolar periphery. Nucleolar changes are paralleled by an increased amount of the DNA damage response indicator γH2AX and DNA unwinding enzyme topoisomerase I in nucleoli and the perinucleolar area suggesting that CX-5461 induces torsional stress and DNA damage in rDNA. This is corroborated by the irreversibility of the observed altered nucleolar phenotypes. We demonstrate that incubation with CX-5461, apart from leading to specific morphological alterations, increases senescence and decreases cell replication. We discuss that these alterations differ from those observed with other drugs interfering with nucleolar functions.
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- 2022
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3. CX-5461 causes nucleolar compaction, alteration of peri- and intranucleolar chromatin arrangement, an increase in both heterochromatin and DNA damage response
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Snyers, Luc, Laffer, Sylvia, Löhnert, Renate, Weipoltshammer, Klara, and Schöfer, Christian
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- 2022
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4. Combining data to perform population-based observational studies: know your sources. The case of thyroid cancer in Belgium
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Decallonne, Brigitte, Snyers, Bérengère, Elaut, Nathalie, Peene, Bernard, Verbeeck, Julie, Van den Bruel, Annick, and De Schutter, Harlinde
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- 2022
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5. Combining data to perform population-based observational studies: know your sources. The case of thyroid cancer in Belgium
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Brigitte Decallonne, Bérengère Snyers, Nathalie Elaut, Bernard Peene, Julie Verbeeck, Annick Van den Bruel, and Harlinde De Schutter
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Administrative data sources ,Population-based observational study ,Thyroid cancer ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Large scale observational studies are crucial to study thyroid cancer incidence and management, known to vary in time and place. Combining cancer registry data with other data sources enables execution of population-based studies, provided data sources are accurate. The objective was to compare thyroid tumour and treatment information between the available data sources in Belgium. Methods We performed a retrospective national population-based cohort study. All patients with thyroid cancer diagnosis in Belgium between 2009 and 2011 (N = 2659 patients) were retrieved from the Belgian Cancer Registry database, containing standard patient and tumour characteristics. Additionally, information was obtained from the following sources: a) detailed pathology reports b) the health insurance company database for reimbursed performed therapeutic acts (both available for N = 2400 patients) c) registration forms for performed and/or planned treatments at the time of the multidisciplinary team meeting (available for N = 1819 patients). More precisely, information was retrieved regarding characteristics of the tumour (histologic subtype, tumour size, lymph node status (source a)) and the treatment (thyroid surgery (a,b,c), lymph node dissection (a,b), postoperative administration of radioactive iodine (b,c)). Results High concordance in histological cancer subtype (> 90%), tumour size (96.2%) and lymph node involvement (89.2%) categories was found between the cancer registry database and the pathology reports. Tumour subcategories (such as microcarcinoma, tumor ≤1 cm diameter) were more specified in the pathology reports. The therapeutic act of thyroid surgery as mentioned in the pathology reports and health insurance company database was concordant in 92.7%, while reports from multidisciplinary team meetings showed 88.5% of concordance with pathology reports and 86.1% with health insurance data. With regard to postoperative radioiodine administration, reports from multidisciplinary teams and health insurance data were concordant in 76.8%. Conclusion Combining registered and/or administrative data results in sufficiently accurate information to perform large scale observational studies on thyroid cancer in Belgium. However, thorough and continuous quality control and insight in strengths and limitations of each cancer data source is crucial.
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- 2022
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6. Age-Related Differences in Patient Preferences for Adjuvant Chemotherapy for High-Risk Endometrial Cancer
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Wakkerman, Famke C., primary, Post, Cathalijne C.B., additional, Mens, Jan-Willem M., additional, Jurgenliemk-Schulz, Ina, additional, Koppe, Friederike, additional, Haverkort, Marie A.D., additional, Roeloffzen, Ellen M.A., additional, Snyers, An, additional, de Jong, Marianne A.A., additional, Schaake, Eva E., additional, Beukema, Jannet C., additional, Cnossen, Jeltsje S., additional, Kiderlen, Mandy, additional, Lutgens, Ludy CHW, additional, Nijman, Hans W., additional, D de Kroon, Cornelis, additional, Kroep, Judith R., additional, Pieterse, Arwen H., additional, Creutzberg, Carien L., additional, and Horeweg, Nanda, additional
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- 2024
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7. Patients' and clinicians' preferences in adjuvant treatment for high-risk endometrial cancer: Implications for shared decision making
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Post, Cathalijne C.B., Mens, Jan Willem M., Haverkort, Marie A.D., Koppe, Friederike, Jürgenliemk-Schulz, Ina M., Snyers, An, Roeloffzen, Ellen M.A., Schaake, Eva E., Slot, Annerie, Stam, Tanja C., Beukema, Jannet C., van den Berg, Hetty A., Lutgens, Ludy C.H.W., Nijman, Hans W., de Kroon, Cornelis D., Kroep, Judith R., Stiggelbout, Anne M., and Creutzberg, Carien L.
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- 2021
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8. Cryptoassets and financial crime
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Houben, Robby, primary and Snyers, Alexander, additional
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- 2021
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9. Comparison and analysis of hyperspectral temperature data in directed energy deposition
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Sanchez-Medina, Jorge, primary, De Baere, Dieter, additional, Snyers, Charles, additional, Jardon, Zoé, additional, Hinderdael, Michaël, additional, Ertveldt, Julien, additional, and Guillaume, Patrick, additional
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- 2023
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10. Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial
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McCormack, M, Whitmarsh, K, Allerton, R, Gregory, D, Symonds, P, Hoskin, PJ, Adusumalli, M, Anand, A, Wade, R, Stewart, A, Taylor, W, Lutgens, LCHW, Hollema, H, Pras, E, Snyers, A, Westerveld, GH, Jobsen, JJ, Slot, A, Mens, JM, Stam, TC, Van Triest, B, Van der Steen-Banasik, EM, De Winter, KAJ, Quinn, MA, Kolodziej, I, Pyman, J, Johnson, C, Capp, A, Fossati, R, Colombo, A, Carinelli, S, Ferrero, A, Artioli, G, Davidson, C, McLachlin, CM, Ghatage, P, Rittenberg, PVC, Souhami, L, Thomas, G, Duvillard, P, Berton-Rigaud, D, Tubiana-Mathieu, N, de Boer, Stephanie M, Powell, Melanie E, Mileshkin, Linda, Katsaros, Dionyssios, Bessette, Paul, Haie-Meder, Christine, Ottevanger, Petronella B, Ledermann, Jonathan A, Khaw, Pearly, D'Amico, Romerai, Fyles, Anthony, Baron, Marie-Helene, Jürgenliemk-Schulz, Ina M, Kitchener, Henry C, Nijman, Hans W, Wilson, Godfrey, Brooks, Susan, Gribaudo, Sergio, Provencher, Diane, Hanzen, Chantal, Kruitwagen, Roy F, Smit, Vincent T H B M, Singh, Naveena, Do, Viet, Lissoni, Andrea, Nout, Remi A, Feeney, Amanda, Verhoeven-Adema, Karen W, Putter, Hein, and Creutzberg, Carien L
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- 2019
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11. Note sur la presence de Caryocolum fischerella (Lepidoptera Gelechiidae) en Belgique
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Baugnee, Jean-Yves, Snyers, Chris, and BioStor
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- 2013
12. L'intervention urbaine un genre démocratique
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Alain Snyers
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mythanalyse ,art ,société ,Social Sciences - Abstract
L’artiste à travers sa pratique de l’art qui agit dans l’espace social occupe ainsi de ce fait une position d’abord d’observateur puis, selon son positionnement, de critique. Cette « fonction » particulière et engagée affirme la volonté non seulement d’indépendance mais aussi et surtout celle de la liberté de création. Par le langage de la création, l’artiste est en mesure de porter un regard critique sur son environnement social et d’initier des formes artistiques liées au fonctionnement des sociétés démocratiques. Parmi la diversité des pratiques artistiques possibles, l’intervention urbaine, manœuvre ou performance, peut se lire et se comprendre comme l’expression de quelques fondamentaux de l’idéal démocratique. Le développement de ces pratiques éphémères au moment notamment de la Guerre froide au cours des années 70, illustre les liens entre expression artistique et aspirations démocratiques. Les fondements de ces multiples démarches et expérimentations, au-delà de leurs formes et esthétiques, demeurent toujours d’actualité, ce qui les définit comme un genre artistique véritablement transversal.
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- 2020
13. Coleophora saponariella (Lepidoptera: Coleophoridae), a new species for the Belgian fauna
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Snyers, Chris, De Prins, Guido, Baugnee, Jean-Yves, Vereecken, Nicolas, and BioStor
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- 2013
14. Ectoedemia louisella, nieuw voor de Belgische fauna (Lepidoptera: Nepticulidae)
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Snyers, Chris and BioStor
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- 2008
15. Phyllocnistis citrella (Lepidoptera: Gracillariidae), een nieuwe, adventieve soort voor de lijst van Belgische Lepidoptera
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Snyers, Chris and BioStor
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- 2007
16. New taxa, including three new genera show uniqueness of Neotropical Nepticulidae (Lepidoptera)
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Erik van Nieukerken, Camiel Doorenweerd, Kenji Nishida, and Chris Snyers
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Zoology ,QL1-991 - Abstract
After finding distinct clades in a molecular phylogeny for Nepticulidae that could not be placed in any known genera and discovering clear apomorphic characters that define these clades, as well as a number of Neotropical species that could be placed in known genera but were undescribed, three new genera and nine new species are here described from the Neotropics: Stigmella gallicola van Nieukerken & Nishida, sp. n. reared from galls on Hampea appendiculata (Malvaceae) in Costa Rica, representing the first example of a gall making Stigmella; S. schinivora van Nieukerken, sp. n. reared from leafmines on Schinus terebinthifolia (Anacardiaceae) in Argentina, Misiones; S. costaricensis van Nieukerken & Nishida, sp. n. and S. intronia van Nieukerken & Nishida, sp. n. each from a single specimen collected the same night in Costa Rica, Parque Nacional Chirripó; S. molinensis van Nieukerken & Snyers, sp. n. reared from leafmines on Salix humboldtiana, Peru, Lima, the first Neotropical species of the Stigmella salicis group sensu stricto; Ozadelpha van Nieukerken, gen. n. with type species O. conostegiae van Nieukerken & Nishida, sp. n., reared from leafmines on Conostegia oerstediana (Melastomataceae) from Costa Rica; Neotrifurcula van Nieukerken, gen. n. with type species N. gielisorum van Nieukerken, sp. n. from Chile; Hesperolyra van Nieukerken, gen. n.. with type species Fomoria diskusi Puplesis & Robinson, 2000; Hesperolyra saopaulensis van Nieukerken, sp. n., reared from an unidentified Myrtaceae, Sao Paulo, Brasil; and Acalyptris janzeni van Nieukerken & Nishida, sp. n. from Costa Rica, Guanacaste. Five new combinations are made: Ozadelpha ovata (Puplesis & Robinson, 2000), comb. n. and Ozadelpha guajavae (Puplesis & Diškus, 2002), comb. n., Hesperolyra diskusi (Puplesis & Robinson, 2000), comb. n., Hesperolyra molybditis (Zeller, 1877), comb. n. and Hesperolyra repanda (Puplesis & Diškus, 2002), comb. n. Three specimens are briefly described, but left unnamed: Ozadelpha specimen EvN4680, Neotrifurcula specimen EvN4504 and Neotrifurcula specimen RH2.
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- 2016
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17. Emerin prevents BAF-mediated aggregation of lamin A on chromosomes in telophase to allow nuclear membrane expansion and nuclear lamina formation
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Snyers, L., primary, Löhnert, R., additional, Weipoltshammer, K., additional, and Schöfer, C., additional
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- 2022
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18. Emerin prevents BAF-mediated aggregation of lamin A on chromosomes in telophase to allow nuclear membrane expansion and nuclear lamina formation
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L. Snyers, R. Löhnert, K. Weipoltshammer, and C. Schöfer
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DNA-Binding Proteins ,Nuclear Lamina ,Nuclear Envelope ,Humans ,Mitosis ,Cell Biology ,Telophase ,Lamin Type A ,Molecular Biology ,Chromosomes ,HeLa Cells - Abstract
Several studies have suggested a role for the LEM-domain protein emerin and the DNA binding factor BAF in nuclear envelope reformation after mitosis, but the exact molecular mechanisms are not understood. Using HeLa cells deficient for emerin or both emerin and lamin A, we show that emerin deficiency induces abnormal aggregation of lamin A at the nuclear periphery in telophase. As a result, nuclear membrane expansion is impaired and BAF accumulates at the core region, the middle part of telophase nuclei. Aggregates do not form when lamin A carries the mutation R435C in the immunoglobulin fold known to prevent interaction of lamin A with BAF suggesting that aggregation is caused by a stabilized association of lamin A with BAF bound to chromosomal DNA. Reintroduction of emerin in the cells prevents formation of lamin A clusters and BAF accumulation at the core region. Therefore emerin is required for the expansion of the nuclear membrane at the core region to enclose the nucleus and for the rapid reformation of the nuclear lamina based on lamin A/C in telophase. Finally, we show that LEM-domain and lumenal domain are required for the targeting of emerin to exert its function at the core region.
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- 2023
19. De feitelijke bestuurder
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Snyers, Alexander and Houben, Robby
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Law - Abstract
In 2019, the Belgian legislator introduced a revised regime on directors’ liability in a new Companies and Associations Code (“CAC”). In the context of that new regime, he opted to not only target formally appointed members of a governing body, but also so-called de facto directors. They are defined in Article 2:56 CAC as “all other persons who have or have had actual governing power with regard to the legal person”. Article 2:56(1), first sentence CAC stipulates that they, like their formally appointed counterparts, are liable for errors committed “in the performance of their mission”. Article 2:143 CAC further stipulates that legal claims for actions undertaken “in relation to their task” are, just like legal claims against formally appointed members of a governing body, time-barred after five years. This normative approach is quite remarkable. After all, doesn’t de facto governance require a de facto interference, independent of or beyond any mission or task? The intervention of the Belgian legislator is conceptually far from clear. Therefore, the following central research question was formulated: “What is the exact scope of the CAC provisions concerning the de facto director and did the legislator do right by introducing these provisions?”. The research shows that different views have emerged in legal doctrine on the exact scope of the provisions (notably on the practical application to the de facto director of the aforementioned Articles 2:56 and 2:143 CAC, as well as Article 2:57 CAC (the cap on liability), which is closely related thereto). Despite this controversy, the legislator was not wrong to introduce them in the CAC. A comparative legal analysis reveals that norms or provisions on de facto governance in general company legislation fulfil, or can fulfil, an important preventive function (i.e., they have a dissuasive effect). In the current text of the CAC, this function is largely absent. A number of substantive proposals for amendments to the text of Articles 2:56, 2:143 and 2:57 CAC are made to address this issue. For some CAC provisions that, at present, clearly do not apply to the de facto director (notably Article 2:58 CAC (the ban on exoneration or indemnification) and Articles 5:104, 6:89 and 7:157 CAC (the derivative claim), the recommendation is to also extent their scope of application to the de facto director.
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- 2023
20. Feitelijk bestuur
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Snyers, Alexander
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Law - Published
- 2023
21. Ondernemings-, economisch en financieel recht
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Snyers, Alexander, Forrier, Edward, Forrier, Alexander, and Verougstraete, Ivan
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Law - Published
- 2023
22. De kwalificatie van de aandeelhouder als feitelijke bestuurder in de Belgische vennootschapsrechtspraak en-rechtsleer : enkele beschouwingen
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Snyers, Alexander
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Law - Published
- 2023
23. Art. 3:103 WVV
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Snyers, Alexander
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Law - Published
- 2023
24. Intranasal Analgosedation for Infants in the Neonatal Intensive Care Unit: A Systematic Review
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Diane Snyers, Sophie Tribolet, and Vincent Rigo
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Pediatrics, Perinatology and Child Health ,Developmental Biology - Abstract
Aim: Pain management is important for newborns’ immediate and long-term well-being. While intranasal analgesia and sedation have been well studied in children, their use could be extended to term and preterm infants. This systematic review aims to assess the use of intranasal medications for procedural analgesia or sedation in the neonatal intensive care unit. Methods: MEDLINE via Ovid, Scopus, Embase, and Cochrane Library were searched independently by two reviewers for clinical studies on sedation or analgesia given intranasally. Results: Seven studies, with 401 patients, were included. The studies described various molecules (midazolam, fentanyl, ketamine, or dexmedetomidine) for different procedures such as intubation in the delivery room, screening for retinopathy, or magnetic resonance imaging. All studies reported significant reduction in pain and sedation markers (based on clinical scales, skin conductance, and clinical variables such as heart rate and crying time). Adverse effects were uncommon and mostly consisted in desaturation, apnoea, hypotension, or paradoxical reactions. Discussion and Conclusion: The intranasal route seems a potential alternative for procedural pain management and sedation in neonates, especially when intravenous access is not available. However, data about safety remain limited. Reported sides effects could be attributed to molecules used rather than the intranasal route. Optimal drugs and doses still need to be characterized. Further studies are needed to ensure safety before promoting a widespread use of intranasal medications in neonatology.
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- 2022
25. Analgosedation before Less-Invasive Surfactant Administration: A Systematic Review
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Sophie Tribolet, Nadège Hennuy, Diane Snyers, Caroline Lefèbvre, and Vincent Rigo
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Pediatrics, Perinatology and Child Health ,Developmental Biology - Abstract
Background: Surfactant therapy is the cornerstone of respiratory distress syndrome management. “Less-invasive surfactant administration (LISA)” is now recommended for spontaneously breathing preterm infants. Analgosedation remains controversial as 52% of European neonatologists do not use any. This systematic review aims to describe the efficacy and safety of different drugs for analgosedation during LISA. Methods: MEDLINE via Ovid, Embase, Scopus, and Cochrane Library of Trials were searched independently by 2 reviewers for studies on sedation or analgesia for LISA, without filters or limits. Results: Eight studies (1 randomized controlled trial) recruiting 945 infants were included. Infant pain was significantly reduced, with more infants evaluated as comfortable. Failure, defined as need for intubation or for a second dose of surfactant, was not different between sedated and unsedated groups. Analgosedation was associated with a higher occurrence of desaturation and need for positive pressure ventilation during procedure, but the need for mechanical ventilation within 24 or 72 h of life was not significantly different. There does not seem to be any difference in clinical tolerance and complications (e.g., hypotension, mortality, air leaks, etc.). Procedural conditions were evaluated as good or excellent in 83% after sedation. Discussion and Conclusion: Analgesia or sedative drugs increase infant comfort and allow good procedural conditions, with a limited impact on the clinical evolution. Questions remain about the best choice of drugs and dosages, with the constraint to maintain spontaneous breathing and have a rapid offset. Further good quality studies are needed to provide additional evidence to supplement those limited existing data.
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- 2022
26. Phase II study of definitive chemoradiation for locally advanced squamous cell cancer of the vulva
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Ina M. Jürgenliemk-Schulz, Elsbieta M. van der Steen-Banasik, Remi A. Nout, Jannet C. Beukema, Max Peters, Baukelien van Triest, Petronella O. Witteveen, Carien L. Creutzberg, Joanne A. de Hullu, Ludy C.H.W. Lutgens, Jacobus van der Velden, Henrike Westerveld, Marnix J.A. Rasing, An Snyers, Radiotherapy, Obstetrics and Gynaecology, CCA -Cancer Center Amsterdam, CCA - Cancer Treatment and Quality of Life, Targeted Gynaecologic Oncology (TARGON), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
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Adult ,medicine.medical_specialty ,CARCINOMA ,Osteoradionecrosis ,MODULATED RADIATION-THERAPY ,medicine.medical_treatment ,EUROPEAN-ORGANIZATION ,Phases of clinical research ,ORAL FLUOROPYRIMIDINE CARBAMATE ,PREOPERATIVE CHEMORADIATION ,Definitive chemoradiotherapy ,Gastroenterology ,Capecitabine ,All institutes and research themes of the Radboud University Medical Center ,SDG 3 - Good Health and Well-being ,QUALITY-OF-LIFE ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Progression-free survival ,Aged ,Aged, 80 and over ,Salvage Therapy ,Chemotherapy ,Toxicity ,Vulvar cancer ,Vulvar Neoplasms ,business.industry ,Obstetrics and Gynecology ,Chemoradiotherapy ,CHEMOTHERAPY ,Middle Aged ,medicine.disease ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,Radiation therapy ,TOXICITY CRITERIA ,Oncology ,Carcinoma, Squamous Cell ,Locally advanced ,Female ,Organ-sparing ,business ,RADIOTHERAPY ,medicine.drug - Abstract
Objective. To evaluate feasibility of chemoradiation as alternative for extensive surgery in patients with locally advanced vulvar cancer and to report on locoregional control, toxicity and survival. Methods. In a multicenter, prospective phase II trial patients with locally advanced vulvar cancer were treated with locoregional radiotherapy combined with sensitizing chemotherapy (capecitabine). Treatment feasibility, percentage locoregional control, survival and toxicity were evaluated. Results. 52 patients with mainly T2/T3 disease were treated according to the study protocol in 10 centers in the Netherlands from 2007 to 2019. Full dose radiotherapy (tumor dose of 64.8Gy) was delivered in 92% and full dose capecitabine in 69% of patients. Most prevalent acute >_ grade 3 toxicities were regarding skin/ mucosa and pain (54% and 37%). Late >_grade 3 toxicity was reported for skin/mucosa (10%), fibrosis (4%), GI incontinence (4%) and stress fracture or osteoradionecrosis (4%). Twelve weeks after treatment, local clinical complete response (cCR) and regional control (RC) rates were 62% and 75%, respectively. After 2 years, local cCR persisted in 22 patients (42%) and RC was 58%. Thirty patients (58%) had no evidence of disease at end of follow-up (median 35 months). In 9 patients (17%) extensive surgery with stoma formation was needed. Progression free survival was 58%, 51% and 45% and overall survival was 76%, 66%, 52% at 1,2, and 5 years. Conclusions. Definitive capecitabine-based chemoradiation as alternative for extensive surgery is feasible in locally advanced vulvar cancer and results in considerable locoregional control with acceptable survival rates with manageable acute and late toxicity. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
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- 2021
27. Patients' and clinicians' preferences in adjuvant treatment for high-risk endometrial cancer
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Cornelis D. de Kroon, Annerie Slot, Jannet C. Beukema, Tanja C. Stam, Judith R. Kroep, Hetty A. van den Berg, Ina M. Jürgenliemk-Schulz, Cathalijne C.B. Post, Jan Willem M. Mens, Ludy C.H.W. Lutgens, F. Koppe, Marie A.D. Haverkort, Ellen M.A. Roeloffzen, An Snyers, Carien L. Creutzberg, Eva E. Schaake, Anne M. Stiggelbout, Hans W. Nijman, Translational Immunology Groningen (TRIGR), Targeted Gynaecologic Oncology (TARGON), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Radiotherapy, Radiotherapie, and RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy
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0301 basic medicine ,medicine.medical_specialty ,Survival ,Clinician preferences ,IMPACT ,medicine.medical_treatment ,THERAPY ,VALIDATION ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,0302 clinical medicine ,Breast cancer ,Quality of life ,Adjuvants, Immunologic ,Endometrial cancer ,SDG 3 - Good Health and Well-being ,QUALITY-OF-LIFE ,Internal medicine ,Surveys and Questionnaires ,medicine ,Adjuvant therapy ,Humans ,BREAST-CANCER ,SYSTEMIC TREATMENT ,Aged ,Netherlands ,Chemotherapy ,business.industry ,Obstetrics and Gynecology ,Patient preferences ,Chemoradiotherapy ,Middle Aged ,CHEMOTHERAPY ,medicine.disease ,Comorbidity ,Combined Modality Therapy ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,Endometrial Neoplasms ,Adjuvant chemotherapy ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Female ,business ,Adjuvant ,Decision Making, Shared ,Decision-making - Abstract
Background. Decision making regarding adjuvant therapy for high-risk endometrial cancer is complex. The aim of this study was to determine patients' and clinicians' minimally desired survival benefit to choose chemoradiotherapy over radiotherapy alone. Moreover, influencing factors and importance of positive and negative treatment effects (i.e. attribute) were investigated.Methods. Patients with high-risk endometrial cancer treated with adjuvant pelvic radiotherapy with or without chemotherapy and multidisciplinary gynaecologic oncology clinicians completed a trade-off questionnaire based on PORTEC-3 trial data.Results. In total, 171 patients and 63 clinicians completed the questionnaire. Median minimally desired benefit to make chemoradiotherapy worthwhile was significantly higher for patients versus clinicians (10% vs 5%, p = 0.02). Both patients and clinicians rated survival benefit most important during decision making, followed by long-term symptoms. Older patients (OR 0.92 [95%CI 0.87 & ndash;0.97]; p = 0.003) with comorbidity (OR 0.34 [95% CI 0.12 & ndash;0.89]; p = 0.035) had lower preference for chemoradiotherapy, while patients with better numeracy skills (OR 1.2 [95%CI 1.05 & ndash;1.36], p = 0.011) and chemoradiotherapy history (OR 25.0 [95%CI 8.8 & ndash;91.7]; p < 0.001) had higher preference for chemoradiotherapy.& nbsp;Conclusions. There is a considerable difference in minimally desired survival benefit of chemoradiotherapy in high-risk endometrial cancer among and between patients and clinicians. Overall, endometrial cancer patients needed higher benefits than clinicians before preferring chemoradiotherapy.(c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
- Published
- 2021
28. Le récit d'une oeuvre: 1975-2015
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Alain Snyers and Alain Snyers
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- 2015
29. Lotka Volterra coevolution at the edge of chaos
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Bourgine, Paul, Snyers, Dominique, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Alliot, Jean-Marc, editor, Lutton, Evelyne, editor, Ronald, Edmund, editor, Schoenauer, Marc, editor, and Snyers, Dominique, editor
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- 1996
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30. Prediction of Melt Pool Temperature for Directed Energy Deposition Using Supervised Learning Methods on Optical Measurement Data
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Jan Helsen, Charles Snyers, Julien Ertveldt, Jorge Sanchez Medina, Zoé Jardon, Faculty of Engineering, Engineering Technology, and Applied Mechanics
- Abstract
One of today's ongoing challenges in directed energy deposition (DED) is controlling the geometry and material properties of parts. The objective of this paper is to investigate the relationship between several printing parameters of DED (laser power, laser speed, powder feed rate) and the melt pool temperature. Because DED is a complex and nonlinear process, well-established supervised-learning models such as support vector regression and artificial neural networks are particularly well suited to represent it. The MiCLAD machine, designed at the Vrije Universiteit Brussel, is equipped with a hyperspectral camera that monitors the light emitted at several wavelengths by the melt pool during the building process. A steady-state data set produced by the hyperspectral camera is postprocessed by an advanced temperature estimation method, and the limitations of the temperature estimation method are identified and discussed. The temperature data are used as training data for supervised-learning methods, and a studyis conducted to compare the performance of the considered methods using the measured optical data. This study demonstrates that the melt pool temperature of the DED process can be effectively modeled through the printing parameters thanks to supervised-learning methods.
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- 2022
31. Word-Finding Intervention for Children with Specific Language Impairment: A Multiple Single-Case Study
- Author
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Bragard, Anne, Schelstraete, Marie-Anne, and Snyers, Perrine
- Abstract
Purpose: This study examined the effectiveness of a combined phonological and semantic intervention for children with specific language impairment who had word-finding difficulties (WFDs). Method: To evaluate the intervention, a multiple single-case design was implemented with 4 children, ages 9;6 (years;months) to 13;9, who had WFDs. Some items were trained using a phonological intervention; others were trained using a semantic one. Lexical access outcomes were measured using a picture-naming test at pre- and posttesting. Results: Three children exhibited a significant reduction in WFDs on the intervention words after 6 sessions. These effects were present at posttest and 6 months later for the treated words only and not the control words. Each child responded differently to the intervention, and these response patterns seemed to be related to each child's linguistic profile. Conclusion: This intervention seemed to achieve long-lasting reductions in children's WFDs. The differential responses to phonological and semantic intervention imply the need to tailor intervention for differing children by matching it to their linguistic profile.
- Published
- 2012
- Full Text
- View/download PDF
32. PORTEC-4a
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Nanda Horeweg, Stefan Kommoss, Ludy C.H.W. Lutgens, Katrien Vandecasteele, Marlies E. Nowee, Remi A. Nout, C. Gillham, Bastiaan G Wortman, F. Koppe, Hetty A. van den Berg, Tjalling Bosse, David Cibula, Karen W Verhoeven-Adema, Annerie Slot, Hein Putter, Cyrus Chargari, Ina M. Jürgenliemk-Schulz, Veronique L M A Coen, Aleida G Zwanenburg, Hans W. Nijman, Carien L. Creutzberg, Elzbieta van der Steen-Banasik, Tanja C. Stam, G Henrieke Westerveld, Anne Sophie V M van den Heerik, Wilbert B. van den Hout, Jan Willem M. Mens, An Snyers, Moritz Hamann, Stefan Bijmolt, CCA - Cancer Treatment and Quality of Life, Radiotherapy, Radiotherapie, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Targeted Gynaecologic Oncology (TARGON), and Translational Immunology Groningen (TRIGR)
- Subjects
medicine.medical_specialty ,CARCINOMA ,SURGERY ,medicine.medical_treatment ,Brachytherapy ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,SDG 3 - Good Health and Well-being ,law ,Internal medicine ,Medicine and Health Sciences ,medicine ,Clinical endpoint ,Humans ,Multicenter Studies as Topic ,External beam radiotherapy ,Stage (cooking) ,endometrium ,Adverse effect ,Mismatch Repair Endonuclease PMS2 ,Randomized Controlled Trials as Topic ,030304 developmental biology ,0303 health sciences ,business.industry ,Endometrial cancer ,Obstetrics and Gynecology ,radiation oncology ,medicine.disease ,Clinical Trial ,Endometrial Neoplasms ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,DNA-Binding Proteins ,Radiation therapy ,MutS Homolog 2 Protein ,Clinical Trials, Phase III as Topic ,Oncology ,EXTERNAL-BEAM RADIOTHERAPY ,030220 oncology & carcinogenesis ,Female ,Radiotherapy, Adjuvant ,MutL Protein Homolog 1 ,business ,Carcinoma, Endometrioid - Abstract
BackgroundVaginal brachytherapy is currently recommended as adjuvant treatment in patients with high-intermediate risk endometrial cancer to maximize local control and has only mild side effects and no or limited impact on quality of life. However, there is still considerable overtreatment and also some undertreatment, which may be reduced by tailoring adjuvant treatment to the patients’ risk of recurrence based on molecular tumor characteristics.Primary objectivesTo compare the rates of vaginal recurrence in women with high-intermediate risk endometrial cancer, treated after surgery with molecular-integrated risk profile-based recommendations for either observation, vaginal brachytherapy or external pelvic beam radiotherapy or with standard adjuvant vaginal brachytherapyStudy hypothesisAdjuvant treatment based on a molecular-integrated risk profile provides similar local control and recurrence-free survival as current standard adjuvant brachytherapy in patients with high-intermediate risk endometrial cancer, while sparing many patients the morbidity of adjuvant treatment and reducing healthcare costs.Trial designA multicenter, international phase III randomized trial (2:1) of molecular-integrated risk profile-based adjuvant treatment (experimental arm) or adjuvant vaginal brachytherapy (standard arm).Major inclusion/exclusion criteriaWomen aged 18 years and over with a histological diagnosis of high-intermediate risk endometrioid endometrial cancer after total abdominal or laparoscopic hysterectomy and bilateral salpingo-oophorectomy. High-intermediate risk factors are defined as: (i) International Federation of Gynecology and Obstetrics stage IA (with invasion) and grade 3; (ii) stage IB grade 1 or 2 with age ≥60 and/or lymph-vascular space invasion; (iii) stage IB, grade 3 without lymph-vascular space invasion; or (iv) stage II (microscopic and grade 1).EndpointsThe primary endpoint is vaginal recurrence. Secondary endpoints are recurrence-free and overall survival; pelvic and distant recurrence; 5-year vaginal control (including treatment for relapse); adverse events and patient-reported symptoms and quality of life; and endometrial cancer-related healthcare costs.Sample size500 eligible and evaluable patients.Estimated dates for completing accrual and presenting resultsEstimated date for completing accrual will be late 2021. Estimated date for presentation of (first) results is expected in 2023.Trial registrationThe trial is registered at clinicaltrials.gov (NCT03469674) and ISRCTN (11659025).
- Published
- 2020
33. Belgium
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Rivière, Inès, Van Goethem, Arvind, and Snyers, Alexander
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Law - Abstract
This country report contains a high-level analysis of the Belgian legal system for use by foreign legal practitioners and other interested actors. It is part of the Doing Business in Europe series, an authoritative, easy-to-follow guide to the legal systems of Europe, providing essential legal information for European businesses and their advisers.
- Published
- 2022
34. Ondernemings-, economisch en financieel recht
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Laforce, Bruno, Stevens, Frank, Snyers, Alexander, Vanovermeire, Vinciane, Forrier, Edward, Forrier, Alexander, and Verougstraet, Ivan
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Law - Published
- 2022
35. Kansen en bekommernissen bij centrale toetsen : echo's uit het Vlaamse onderwijsveld
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Vanhoof, Jan, Goffin, Evelyn, De Maeyer, Shana, Eysermans, Cin, and Snyers, Sofie
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Educational sciences - Abstract
Vanaf schooljaar 2023-2024 zullen alle Vlaamse leerlingen tijdens hun schoolloopbaan vier keer een centrale toets afleggen. Het doel van deze studie was om de percepties en de verwachtingen van leraren, schoolleiders en pedagogisch begeleiders bij deze beleidsbeslissing in kaart te brengen. Aan de hand van 34 explorerend kwalitatieve semigestructureerde interviews werd daartoe empirische evidentie verzameld. Verwachte wenselijke en onwenselijke effecten van het voorziene systeem worden belicht. Daarnaast wordt ingegaan op een set van sleutelkenmerken die leerkrachten, schoolleiders en pedagogisch begeleiders vooropstellen zodat centrale toetsen een optimale kans op slagen zouden hebben bij verdere implementatie. De resultaten tonen aan dat vooral een ontwikkelingsgericht perspectief aanbevolen wordt. Verder wordt onder meer gepleit voor een brede toetsing, secure omgang inzake de openbaarheid van resultaten, en inzetten op de ontwikkeling van informatiegeletterdheid van toekomstige gebruikers.
- Published
- 2022
36. New results on an ant-based heuristic for highlighting the organization of large graphs.
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Pascale Kuntz and Dominique Snyers
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- 1999
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37. Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial
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Carien L. Creutzberg, Petronella B. Ottevanger, Annamaria Ferrero, Luis Souhami, Pearly Khaw, GH Westerveld, Diane Provencher, Gillian Thomas, Jan Pyman, V. Do, Annerie Slot, C Davidson, G. Wilson, Stephanie M. de Boer, Peter Hoskin, C M McLachlin, Michael A. Quinn, Deborah Gregory, Remi A. Nout, Hans W. Nijman, J.J. Jobsen, Tanja C. Stam, Vincent T.H.B.M. Smit, K Whitmarsh, Paul Bessette, Roy F.P.M. Kruitwagen, W Taylor, Dionyssios Katsaros, Chantal Hanzen, Henry C Kitchener, M McCormack, Prafull Ghatage, Dominique Berton-Rigaud, J.W.M. Mens, Melanie E Powell, Elisabeth Pras, Jonathan A. Ledermann, Karen W Verhoeven-Adema, Harmen Hollema, Andrea Lissoni, Linda Mileshkin, Anjana Anand, Amanda Feeney, Sergio Gribaudo, Marie-Helene Baron, R Allerton, Hein Putter, Colin D. Johnson, P. Symonds, Ina M. Jürgenliemk-Schulz, Romerai D'Amico, Ilka Kolodziej, M Adusumalli, Naveena Singh, G Artioli, An Snyers, R Wade, Christine Haie-Meder, Roldano Fossati, Nicole Tubiana-Mathieu, Anthony Fyles, Silvestro Carinelli, Anne Capp, Alexandra J. Stewart, Kaj De Winter, B. van Triest, L.C.H.W. Lutgens, Susan Brooks, E. Van der Steen-Banasik, Pierre Duvillard, Pvc Rittenberg, Alessandro Colombo, de Boer, S, Powell, M, Mileshkin, L, Katsaros, D, Bessette, P, Haie-Meder, C, Ottevanger, P, Ledermann, J, Khaw, P, D'Amico, R, Fyles, A, Baron, M, Jurgenliemk-Schulz, I, Kitchener, H, Nijman, H, Wilson, G, Brooks, S, Gribaudo, S, Provencher, D, Hanzen, C, Kruitwagen, R, Smit, V, Singh, N, Do, V, Lissoni, A, Nout, R, Feeney, A, Verhoeven-Adema, K, Putter, H, Creutzberg, C, Mccormack, M, Whitmarsh, K, Allerton, R, Gregory, D, Symonds, P, Hoskin, P, Adusumalli, M, Anand, A, Wade, R, Stewart, A, Taylor, W, Lutgens, L, Hollema, H, Pras, E, Snyers, A, Westerveld, G, Jobsen, J, Slot, A, Mens, J, Stam, T, Van Triest, B, Van der Steen-Banasik, E, De Winter, K, Quinn, M, Kolodziej, I, Pyman, J, Johnson, C, Capp, A, Fossati, R, Colombo, A, Carinelli, S, Ferrero, A, Artioli, G, Davidson, C, Mclachlin, C, Ghatage, P, Rittenberg, P, Souhami, L, Thomas, G, Duvillard, P, Berton-Rigaud, D, Tubiana-Mathieu, N, MUMC+: MA Toegelatenen Obstetrie Gynaecologie (9), MUMC+: MA Obstetrie Gynaecologie (3), MUMC+: MA Arts Assistenten Obstetrie Gynaecologie (9), RS: GROW - R2 - Basic and Translational Cancer Biology, Obstetrie & Gynaecologie, Translational Immunology Groningen (TRIGR), and Targeted Gynaecologic Oncology (TARGON)
- Subjects
0301 basic medicine ,medicine.medical_specialty ,medicine.medical_treatment ,MED/40 - GINECOLOGIA E OSTETRICIA ,MULTICENTER ,THERAPY ,CARCINOMA PATIENTS ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Survival analysis ,MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA ,III TRIAL ,Manchester Cancer Research Centre ,Performance status ,business.industry ,ResearchInstitutes_Networks_Beacons/mcrc ,Endometrial cancer ,Hazard ratio ,CHEMOTHERAPY ,OPEN-LABEL ,medicine.disease ,Carboplatin ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,IRRADIATION ,3. Good health ,Radiation therapy ,030104 developmental biology ,Oncology ,chemistry ,Endometrial cancer, radiotherapy, chemotherapy, adjuvant treatment ,030220 oncology & carcinogenesis ,MED/06 - ONCOLOGIA MEDICA ,RADIATION ,Lymphadenectomy ,business ,Chemoradiotherapy - Abstract
BACKGROUND:The PORTEC-3 trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy versus pelvic radiotherapy alone for women with high-risk endometrial cancer. We updated the analysis to investigate patterns of recurrence and did a post-hoc survival analysis.METHODS:In the multicentre randomised phase 3 PORTEC-3 trial, women with high-risk endometrial cancer were eligible if they had International Federation of Gynaecology and Obstetrics (FIGO) 2009 stage I, endometrioid grade 3 cancer with deep myometrial invasion or lymphovascular space invasion, or both; stage II or III disease; or stage I-III disease with serous or clear cell histology; were aged 18 years and older; and had a WHO performance status of 0-2. Participants were randomly assigned (1:1) to receive radiotherapy alone (48·6 Gy in 1·8 Gy fractions given on 5 days per week) or chemoradiotherapy (two cycles of cisplatin 50 mg/m2 given intravenously during radiotherapy, followed by four cycles of carboplatin AUC5 and paclitaxel 175 mg/m2 given intravenously), by use of a biased coin minimisation procedure with stratification for participating centre, lymphadenectomy, stage, and histological type. The co-primary endpoints were overall survival and failure-free survival. Secondary endpoints of vaginal, pelvic, and distant recurrence were analysed according to the first site of recurrence. Survival endpoints were analysed by intention-to-treat, and adjusted for stratification factors. Competing risk methods were used for failure-free survival and recurrence. We did a post-hoc analysis to analyse patterns of recurrence with 1 additional year of follow-up. The study was closed on Dec 20, 2013; follow-up is ongoing. This study is registered with ISRCTN, number ISRCTN14387080, and ClinicalTrials.gov, number NCT00411138.FINDINGS:Between Nov 23, 2006, and Dec 20, 2013, 686 women were enrolled, of whom 660 were eligible and evaluable (330 in the chemoradiotherapy group, and 330 in the radiotherapy-alone group). At a median follow-up of 72·6 months (IQR 59·9-85·6), 5-year overall survival was 81·4% (95% CI 77·2-85·8) with chemoradiotherapy versus 76·1% (71·6-80·9) with radiotherapy alone (adjusted hazard ratio [HR] 0·70 [95% CI 0·51-0·97], p=0·034), and 5-year failure-free survival was 76·5% (95% CI 71·5-80·7) versus 69·1% (63·8-73·8; HR 0·70 [0·52-0·94], p=0·016). Distant metastases were the first site of recurrence in most patients with a relapse, occurring in 78 of 330 women (5-year probability 21·4%; 95% CI 17·3-26·3) in the chemoradiotherapy group versus 98 of 330 (5-year probability 29·1%; 24·4-34·3) in the radiotherapy-alone group (HR 0·74 [95% CI 0·55-0·99]; p=0·047). Isolated vaginal recurrence was the first site of recurrence in one patient (0·3%; 95% CI 0·0-2·1) in both groups (HR 0·99 [95% CI 0·06-15·90]; p=0·99), and isolated pelvic recurrence was the first site of recurrence in three women (0·9% [95% CI 0·3-2·8]) in the chemoradiotherapy group versus four (0·9% [95% CI 0·3-2·8]) in the radiotherapy-alone group (HR 0·75 [95% CI 0·17-3·33]; p=0·71). At 5 years, only one grade 4 adverse event (ileus or obstruction) was reported (in the chemoradiotherapy group). At 5 years, reported grade 3 adverse events did not differ significantly between the two groups, occurring in 16 (8%) of 201 women in the chemoradiotherapy group versus ten (5%) of 187 in the radiotherapy-alone group (p=0·24). The most common grade 3 adverse event was hypertension (in four [2%] women in both groups). At 5 years, grade 2 or worse adverse events were reported in 76 (38%) of 201 women in the chemoradiotherapy group versus 43 (23%) of 187 in the radiotherapy-alone group (p=0·002). Sensory neuropathy persisted more often after chemoradiotherapy than after radiotherapy alone, with 5-year rates of grade 2 or worse neuropathy of 6% (13 of 201 women) versus 0% (0 of 187). No treatment-related deaths were reported.INTERPRETATION:This updated analysis shows significantly improved overall survival and failure-free survival with chemoradiotherapy versus radiotherapy alone. This treatment schedule should be discussed and recommended, especially for women with stage III or serous cancers, or both, as part of shared decision making between doctors and patients. Follow-up is ongoing to evaluate long-term survival.FUNDING:Dutch Cancer Society, Cancer Research UK, National Health and Medical Research Council, Project Grant, Cancer Australia Grant, Italian Medicines Agency, and the Canadian Cancer Society Research Institute.
- Published
- 2019
38. Intranasal Analgosedation for Infants in the Neonatal Intensive Care Unit: A Systematic Review
- Author
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Snyers, Diane, primary, Tribolet, Sophie, additional, and Rigo, Vincent, additional
- Published
- 2022
- Full Text
- View/download PDF
39. Analgosedation before Less-Invasive Surfactant Administration: A Systematic Review
- Author
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Tribolet, Sophie, primary, Hennuy, Nadège, additional, Snyers, Diane, additional, Lefèbvre, Caroline, additional, and Rigo, Vincent, additional
- Published
- 2022
- Full Text
- View/download PDF
40. Axial cortical involvement of metastatic lesions to identify impending femoral fractures; a clinical validation study
- Author
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A. Snyers, P. D. S. Dijkstra, Marta Fiocco, A. Slot, Y.M. van der Linden, C. W. P. G. van der Wal, Florieke Eggermont, Herman M. Kroon, O. Ayu, Esther Tanck, Nico Verdonschot, Tom Rozema, and Biomechanical Engineering
- Subjects
medicine.medical_specialty ,Validation study ,Radiograph ,Metastatic lesions ,Survival ,Radiography ,medicine.medical_treatment ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,0302 clinical medicine ,Risk Factors ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Femur ,Prospective Studies ,Prospective cohort study ,Retrospective Studies ,business.industry ,Bone metastases ,Pathological fracture ,22/2 OA procedure ,Reproducibility of Results ,Hematology ,Femoral fracture ,medicine.disease ,Predictive value ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Radiation therapy ,Fractures, Spontaneous ,Oncology ,030220 oncology & carcinogenesis ,Radiology ,business ,Femoral Fractures - Abstract
Background and purpose: Patients with advanced cancer may develop painful bone metastases, potentially resulting in pathological fractures. Adequate fracture risk assessment is of key importance to prevent fracturing and maintain mobility. This study aims to validate the clinical reliability of axial cortical involvement with a 30 mm threshold on conventional radiographs to assess fracture risk in femoral bone metastases.Materials and methods: All patients with bone metastases who received radiotherapy for pain included in two multicentre prospective studies were selected. Conventional radiographs obtained at a maximum of two months prior to radiotherapy were collected. Three experts independently measured lesions and scored radiographic characteristics. Sensitivity, specificity, positive (PPV) and negative predictive value (NPV) were calculated.Results: Hundred patients were included with a median follow-up of 23.0 months (95%CI: 10.6-35.5). Two fractures occurred in lesions with axial cortical involvement = 30 mm. Sensitivity, specificity, PPV and NPV of axial cortical involvement for predicting femoral fractures were 86%, 50%, 20% and 96%, respectively. Patients with lesions >= 30 mm had a 5.3 times higher fracture risk than patients with smaller lesions.Conclusion: Our validation study confirmed the use of 30 mm axial cortical involvement to assess fracture risk in femoral bone metastases. Until a more accurate and practically feasible method has been developed, this clinical parameter remains an easy method to assess femoral fracture risk to aid patients and clinicians to choose the optimal individual treatment modality. (C) 2019 Elsevier B.V. All rights reserved.
- Published
- 2020
41. Routing in Telecommunications Networks with Ant-Like Agents.
- Author
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Eric Bonabeau, Florian Hénaux, Sylvain Guérin, Dominique Snyers, Pascale Kuntz, and Guy Theraulaz
- Published
- 1998
- Full Text
- View/download PDF
42. Routing in telecommunications networks with ant-like agents
- Author
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Bonabeau, Eric, Henaux, Florian, Guérin, Sylvain, Snyers, Dominique, Kuntz, Pascale, Theraulaz, Guy, Carbonell, Jaime G., editor, Siekmann, Jöorg, editor, Goos, G., editor, Hartmanis, J., editor, van Leeuwen, J., editor, Albayrak, Sahin, editor, and Garijo, Francisco J., editor
- Published
- 1998
- Full Text
- View/download PDF
43. Mimicry and Coevolution of Hedonic Agents.
- Author
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Paul Bourgine and Dominique Snyers
- Published
- 1995
- Full Text
- View/download PDF
44. Lotka Volterra Coevolution at the Edge of Chaos.
- Author
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Paul Bourgine and Dominique Snyers
- Published
- 1995
- Full Text
- View/download PDF
45. Mimicry and coevolution of hedonic agents
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Bourgine, Paul, Snyers, Dominique, Goos, G., editor, Hartmanis, J., editor, van Leeuwen, J., editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Morán, Federico, editor, Moreno, Alvaro, editor, Merelo, Juan Julián, editor, and Chacón, Pablo, editor
- Published
- 1995
- Full Text
- View/download PDF
46. Prediction of build geometry for DED using supervised learning methods on simulated process monitoring data
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Snyers, Charles, primary, Ertveldt, Julien, additional, Sanchez-Medina, Jorge, additional, Jardon, Zoé, additional, and Helsen, Jan, additional
- Published
- 2021
- Full Text
- View/download PDF
47. Phase II study of definitive chemoradiation for locally advanced squamous cell cancer of the vulva: An efficacy study
- Author
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van Triest, Baukelien, primary, Rasing, Marnix, additional, van der Velden, Jacobus, additional, de Hullu, Joanne, additional, Witteveen, Petronella O., additional, Beukema, Jannet C., additional, van der Steen-Banasik, Elsbieta, additional, Westerveld, Henrike, additional, Snyers, An, additional, Peters, Max, additional, Creutzberg, Carien L., additional, Nout, Remi A., additional, Lutgens, Ludy, additional, and Jürgenliemk-Schulz, Ina, additional
- Published
- 2021
- Full Text
- View/download PDF
48. Clique Partitioning Problem and Genetic Algorithms
- Author
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Snyers, Dominique, Albrecht, Rudolf F., editor, Reeves, Colin R., editor, and Steele, Nigel C., editor
- Published
- 1993
- Full Text
- View/download PDF
49. Cryptoassets and financial crime
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Robby Houben and Alexander Snyers
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Financial system ,Business - Published
- 2021
50. OC-0300 Patients’ and clinicians’ preferences in adjuvant treatment for high-risk endometrial cancer
- Author
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Post, C., primary, Mens, J.W., additional, Haverkort, M., additional, Koppe, F., additional, Jürgenliemk-Schulz, I., additional, Snyers, A., additional, Roeloffzen, E., additional, Schaake, E., additional, Slot, A., additional, Stam, T., additional, Beukema, J., additional, van den Berg, H., additional, Lutgens, L., additional, Nijman, H., additional, de Kroon, C., additional, Kroep, J., additional, Stiggelbout, A., additional, and Creutzberg, C., additional
- Published
- 2021
- Full Text
- View/download PDF
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