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1. Safety Assessment of Palm-Derived Ingredients as Used in Cosmetics

Author

Johnson, Wilbur, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Peterson, Lisa A., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2024
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2. Safety Assessment of Hydrogen Peroxide as Used in Cosmetics

Author

Becker, Lillian C., primary, Cherian, Priya A., additional, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2024
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3. Safety Assessment of Basic Red 76 as Used in Cosmetics

Author

Cherian, Priya, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2024
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4. Safety Assessment of Polysilicone-11 as Used in Cosmetics

Author

Cherian, Priya, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Peterson, Lisa A., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2024
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5. Safety Assessment of Alkane Diols as Used in Cosmetics

Author

Scott, Laura N., primary, Fiume, Monice, additional, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, and Heldreth, Bart, additional

Published
2024
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6. Safety Assessment of Butyrospermum parkii (Shea)-Derived Ingredients as Used in Cosmetics

Author

Burnett, Christina L., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2024
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9. Safety Assessment of Adenosine as Used in Cosmetics

Author

Cherian, Priya, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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10. Safety Assessment of Alkyl Sultaines as Used in Cosmetics

Author

Burnett, Christina L., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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11. Safety Assessment of Hops as Used in Cosmetics

Author

Becker, Lillian, primary, Boyer, Ivan, additional, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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12. Sulfites

Author

Johnson, Wilbur, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Peterson, Lisa A., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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13. Peanut Glycerides

Author

Raj, Preethi S., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Rettie, Allan E, additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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14. Lard and Lard-Derived Ingredients

Author

Becker, Lillian C., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Gill, Lillian J., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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15. Imidazolidinyl Urea

Author

Burnett, Christina, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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16. Hexamidine and Hexamidine Diisethionate

Author

Cherian, Priya, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E., additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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17. Acetyl Trialkyl Citrates

Author

Johnson, Wilbur, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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18. Aluminum Starch Octenylsuccinate

Author

Akinsulie, Alice, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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19. Amyl Acetate and Isoamyl Acetate

Author

Cherian, Pryia, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E., additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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20. EDTA and Salts

Author

Cherian, Priya, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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21. Triacetin

Author

Fiume, Monice, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, and Heldreth, Bart, additional

Published
2023
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22. Prunus Amygdalus Dulcis (Sweet Almond) Seed Meal

Author

Burnett, Christina L., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Rettie, Allan E., additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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23. Quaternium-18 and Quaternium-18 Bentonite

Author

Cherian, Priya, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Peterson, Lisa A., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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24. Quaternium-26

Author

Johnson, Wilbur, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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25. Erythorbic Acid and Sodium Erythorbate

Author

Raj, Preethi S., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E, additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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26. Sodium α-Olefin Sulfonates

Author

Becker, Lillian C., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Gill, Lillian J., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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27. Cottonseed Glyceride and Hydrogenated Cottonseed Glyceride

Author

Raj, Preethi S., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E, additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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28. Glycol Stearate and Glycol Stearate SE

Author

Tucker, Regina, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E., additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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29. Sodium Naphthalenesulfonate and Sodium Polynaphthalenesulfonate

Author

Burnett, Christina, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Gill, Lillian J., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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30. PPG-11 and PPG-15 Stearyl Ether

Author

Cherian, Pryia, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E, additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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31. Chloroxylenol

Author

Cherian, Priya, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E, additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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32. Sodium Lauryl Sulfoacetate

Author

Burnett, Christina L., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E, additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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33. Polyacrylamide

Author

Raj, Preethi S., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E., additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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34. Polyamino Sugar Condensate

Author

Raj, Preethi S., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Rettie, Allan E, additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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35. Choleth-24

Author

Cherian, Priya, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Rettie, Allan E., additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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36. HC Yellow 5

Author

Burnett, Christina L., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E., additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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37. Dioscorea Villosa (Wild Yam) Root Extract

Author

Raj, Preethi S., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Rettie, Allan E, additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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38. Mink Oil

Author

Tucker, Regina, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E., additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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39. Phytantriol

Author

Tucker, Regina, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Rettie, Allan E., additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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40. Acid Orange 3

Author

Burnett, Christina L., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E, additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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41. PEG Soy Sterols

Author

Cherian, Priya, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E, additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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42. BHT – Butylated Hydroxytoluene

Author

Burnett, Christina, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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43. Methyl Alcohol

Author

Raj, Preethi S., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Rettie, Allan E, additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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44. Squalane and Squalene

Author

Fiume, Monice, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, and Heldreth, Bart, additional

Published
2023
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45. Glyceryl Diesters

Author

Raj, Preethi S., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Cohen, David E., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Rettie, Allan E., additional, Ross, David, additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, Tilton, Susan, additional, Fiume, Monice, additional, and Heldreth, Bart, additional

Published
2023
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46. Biotin

Author

Fiume, Monice, primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, and Heldreth, Bart, additional

Published
2023
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48. Collagen-binding peptidoglycans inhibit MMP mediated collagen degradation and reduce dermal scarring.

Author

Stuart, Kate, Paderi, John, Snyder, Paul W, Freeman, Lynetta, and Panitch, Alyssa

Subjects
Skin, Animals, Rats, Rats, Long-Evans, Collagen, Matrix Metalloproteinases, Peptidoglycan, Microscopy, Electron, Transmission, Wound Healing, Tensile Strength, Male, Microscopy, Electron, Transmission, Long-Evans, General Science & Technology
Abstract

Scarring of the skin is a large unmet clinical problem that is of high patient concern and impact. Wound healing is complex and involves numerous pathways that are highly orchestrated, leaving the skin sealed, but with abnormal organization and composition of tissue components, namely collagen and proteoglycans, that are then remodeled over time. To improve healing and reduce or eliminate scarring, more rapid restoration of healthy tissue composition and organization offers a unique approach for development of new therapeutics. A synthetic collagen-binding peptidoglycan has been developed that inhibits matrix metalloproteinase-1 and 13 (MMP-1 and MMP-13) mediated collagen degradation. We investigated the synthetic peptidoglycan in a rat incisional model in which a single dose was delivered in a hyaluronic acid (HA) vehicle at the time of surgery prior to wound closure. The peptidoglycan treatment resulted in a significant reduction in scar tissue at 21 days as measured by histology and visual analysis. Improved collagen architecture of the treated wounds was demonstrated by increased tensile strength and transmission electron microscopy (TEM) analysis of collagen fibril diameters compared to untreated and HA controls. The peptidoglycan's mechanism of action includes masking existing collagen and inhibiting MMP-mediated collagen degradation while modulating collagen organization. The peptidoglycan can be synthesized at low cost with unique design control, and together with demonstrated preclinical efficacy in reducing scarring, warrants further investigation for dermal wound healing.

Published
2011

49. Amended Safety Assessment of Dialkyl Dimer Dilinoleates as Used in Cosmetics

Author

Cherian, Priya A., primary, Bergfeld, Wilma F., additional, Belsito, Donald V., additional, Hill, Ronald A., additional, Klaassen, Curtis D., additional, Liebler, Daniel C., additional, Marks, James G., additional, Shank, Ronald C., additional, Slaga, Thomas J., additional, Snyder, Paul W., additional, and Heldreth, Bart, additional

Published
2023
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