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18 results on '"Snyder, Deann T."'

1. Severe Acute Respiratory Syndrome Coronavirus 2 Is Detected in the Gastrointestinal Tract of Asymptomatic Endoscopy Patients but Is Unlikely to Pose a Significant Risk to Healthcare Personnel

Author

Cherne, Michelle D., Gentry, Andrew B., Nemudraia, Anna, Nemudryi, Artem, Hedges, Jodi F., Walk, Heather, Blackwell, Karlin, Snyder, Deann T., Jerome, Maria, Madden, Wyatt, Hashimi, Marziah, Sebrell, T. Andrew, King, David B., Plowright, Raina K., Jutila, Mark A., Wiedenheft, Blake, and Bimczok, Diane

Published
2022
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9. Effect of Inactivation Methods on SARS-CoV-2 Virion Protein and Structure

Author

Loveday, Emma K., primary, Hain, Kyle S., additional, Kochetkova, Irina, additional, Hedges, Jodi F., additional, Robison, Amanda, additional, Snyder, Deann T., additional, Brumfield, Susan K., additional, Young, Mark J., additional, Jutila, Mark A., additional, Chang, Connie B., additional, and Taylor, Matthew P., additional

Published
2021
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10. SARS-CoV-2 genomic surveillance identifies naturally occurring truncations of ORF7a that limit immune suppression

Author

Nemudryi, Artem, primary, Nemudraia, Anna, additional, Wiegand, Tanner, additional, Nichols, Joseph, additional, Snyder, Deann T, additional, Hedges, Jodi F, additional, Cicha, Calvin, additional, Lee, Helen, additional, Vanderwood, Karl K, additional, Bimczok, Diane, additional, Jutila, Mark, additional, and Wiedenheft, Blake, additional

Published
2021
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11. Effects of inactivation method on SARS-CoV-2 virion protein and structure

Author

Loveday, Emma K., primary, Hain, Kyle S., additional, Kochetkova, Irina, additional, Hedges, Jodi F., additional, Robison, Amanda, additional, Snyder, Deann T., additional, Brumfield, Susan K., additional, Young, Mark J., additional, Jutila, Mark A., additional, Chang, Connie B., additional, and Taylor, Matthew P., additional

Published
2020
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12. Intrinsic Signal Amplification by Type-III CRISPR-Cas Systems Provides a Sequence-Specific Viral Diagnostic

Author

Santiago-Frangos, Andrew, primary, Hall, Laina N., additional, Nemudraia, Anna, additional, Nemudryi, Artem, additional, Krishna, Pushya, additional, Wiegand, Tanner, additional, Wilkinson, Royce A., additional, Snyder, Deann T., additional, Hedges, Jodi F., additional, Jutila, Mark A., additional, Taylor, Matthew P., additional, and Wiedenheft, Blake, additional

Published
2020
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14. Getting 'Inside' Type I IFNs: Type I IFNs in Intracellular Bacterial Infections

Author

Snyder, Deann T., Hedges, Jodi F., and Jutila, Mark A.

Subjects
Article Subject
Abstract

Type I interferons represent a unique and complex group of cytokines, serving many purposes during innate and adaptive immunity. Discovered in the context of viral infections, type I IFNs are now known to have myriad effects in infectious and autoimmune disease settings. Type I IFN signaling during bacterial infections is dependent on many factors including whether the infecting bacterium is intracellular or extracellular, as different signaling pathways are activated. As such, the repercussions of type I IFN induction can positively or negatively impact the disease outcome. This review focuses on type I IFN induction and downstream consequences during infection with the following intracellular bacteria: Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Salmonella enterica serovar Typhimurium, Francisella tularensis, Brucella abortus, Legionella pneumophila, and Coxiella burnetii. Intracellular bacterial infections are unique because the bacteria must avoid, circumvent, and even co-opt microbial “sensing” mechanisms in order to reside and replicate within a host cell. Furthermore, life inside a host cell makes intracellular bacteria more difficult to target with antibiotics. Because type I IFNs are important immune effectors, modulating this pathway may improve disease outcomes. But first, it is critical to understand the context-dependent effects of the type I IFN pathway in intracellular bacterial infections.

Published
2017
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18. SARS-CoV-2 genomic surveillance identifies naturally occurring truncations of ORF7a that limit immune suppression.

Author

Nemudryi A, Nemudraia A, Wiegand T, Nichols J, Snyder DT, Hedges JF, Cicha C, Lee H, Vanderwood KK, Bimczok D, Jutila M, and Wiedenheft B

Abstract

Over 200,000 whole genome sequences of SARS-CoV-2 have been determined for viruses isolated from around the world. These sequences have been critical for understanding the spread and evolution of SARS-CoV-2. Using global phylogenomics, we show that mutations frequently occur in the C-terminal end of ORF7a. We have isolated one of these mutant viruses from a patient sample and used viral challenge experiments to demonstrate that Δ115 mutation results in a growth defect. ORF7a has been implicated in immune modulation, and we show that the C-terminal truncation results in distinct changes in interferon stimulated gene expression. Collectively, this work indicates that ORF7a mutations occur frequently and that these changes affect viral mechanisms responsible for suppressing the immune response., Competing Interests: Declaration of interests B.W. is the founder of SurGene LLC, and VIRIS Detection Systems Inc. B.W., A. Nemudryi, and A. Nemudraia are inventors on patents related to CRISPR-Cas systems and applications thereof.

Published
2021
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