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2. Visualizing the Human Body Using an Artistic Approach

Author

Crossing, Elisa, Smyth, Lillian, Valter, Krisztina, Webb, Alexandra, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Shapiro, Leonard, editor, and Rea, Paul M., editor

Published
2023
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3. The Question of Dissection in Medical Training: Not Just 'If,' but 'When'? A Student Perspective

Author

Webb, Alexandra L., Smyth, Lillian, Hafiz, Mustafa, and Valter, Krisztina

Abstract

While debate about the use of--and alternatives to--human cadaveric dissection in medical training is robust, little attention has been paid to questions about timing. This study explores the perspectives of medical students and recent graduates with regard to two key questions: when in the degree program do students prefer dissection opportunities and what are the students getting out of participating in dissection? Self-report survey data from students in preclinical years (n = 105), clinical years (n = 57), and graduates (n = 13) were analyzed. Most (89%) preferred dissection during the preclinical years, with no effect by training year (X[superscript 2] = 1.98, p = 0.16), previous anatomy (X[superscript 2] = 3.64, p = 0.31), or dissection (X[superscript 2] = 3.84, p = 0.26) experience. Three key findings emerged. First, the majority of students prefer to dissect in the preclinical years because they view dissection as important for developing foundation knowledge and delivering an opportunity for consolidation prior to transitioning to primarily clinical studies. In addition, students recognize that it is a time-consuming activity requiring specialized facilities. Second, three main understandings of the purpose of dissection were reported: depth of learning, learning experience, and real-world equivalence. Third, these student perspectives of the purpose of dissection are associated with timing preferences for dissection opportunities. The results identify the preclinical phase as the optimal time to strategically integrate dissection into medical training in order to maximize the benefits of this unique learning opportunity for students and minimize its impact upon curricular time.

Published
2022
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6. Examining the Short-, Medium-, and Long-Term Success of an Embodied Learning Activity in the Study of Hand Anatomy for Clinical Application

Author

Smyth, Lillian, Carter, James, Valter, Krisztina, and Webb, Alexandra L.

Abstract

A student's own body provides an often disregarded site of knowledge production and corporeal wisdom. Learning via cognitive processes anchored in physical movement and body awareness, known as embodied learning, may aid students to visualize structures and understand their functions and clinical relevance. Working from an embodied learning perspective, the current article evaluates the use of an offline physical learning tool (Anatomical Glove Learning System; AGLS) for teaching hand anatomy for clinical application in medical students. Two student samples (N[subscript 1] = 105; N[subscript 2] = 94) used the AGLS in two different ways. In the first sample, the AGLS was compared to a traditional approach using hand bones, models and prosected specimens. Secondly, the AGLS and traditional approach were combined. The evaluation consisted of three outcomes: short-term learning (post-test), medium-term applications (mock-objective structured clinical examination, MOSCE), and longer-term assessment (objective structured clinical examination, OSCE). Findings from the first sample indicated no significant differences between the AGLS and traditional laboratory groups on short- (F[subscript (1,78)] = 0.036, P = 0.849), medium- (F[subscript (1,50)] = 0.743, P = 0.393), or longer-term (F[subscript (1,82)] = 0.997, P = 0.321) outcomes. In the second sample using the AGLS in combination with a traditional approach was associated with significantly better short-term post-test scores (F[subscript (2,174)] = 5.98, P = 0.003) than using the AGLS alone, but demonstrated no effect for long-term OSCE scores. These results suggest an embodied learning experience alone does not appear to be advantageous to student learning, but when combined with other methods for studying anatomy there are learning gains.

Published
2021
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7. How Can We Show You, if You Can't See It? Trialing the Use of an Interactive Three-Dimensional Micro-CT Model in Medical Education

Author

O'Rourke, Joseph C., Smyth, Lillian, Webb, Alexandra L., and Valter, Krisztina

Abstract

Teaching internal structures obscured from direct view is a major challenge of anatomy education. High-fidelity interactive three-dimensional (3D) micro-computed tomography (CT) models with virtual dissection present a possible solution. However, their utility for teaching complex internal structures of the human body is unclear. The purpose of this study was to investigate the use of a realistic 3D micro-CT interactive visualization computer model to teach paranasal sinus anatomy in a laboratory setting during pre-clinical medical training. Year 1 (n = 79) and Year 2 (n = 59) medical students undertook self-directed activities focused on paranasal sinus anatomy in one of two laboratories (traditional laboratory and 3D model). All participants completed pre and posttests before and after the laboratory session. Results of regression analyses predicting post-laboratory knowledge indicate that, when students were inexperienced with the 3D computer technology, use of the model was detrimental to learning for students with greater prior knowledge of the relevant anatomy (P < 0.05). For participants experienced with the 3D computer technology, however, the use of the model was detrimental for students with "less" prior knowledge of the relevant anatomy (P < 0.001). These results emphasize that several factors need to be considered in the design and effective implementation of such models in the classroom. Under the right conditions, the 3D model is equal to traditional laboratory resources when used as a learning tool. This paper discusses the importance of preparatory training for students and the technical consideration necessary to successfully integrate such models into medical anatomical curricula.

Published
2020
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8. AKT mutant allele-specific activation dictates pharmacologic sensitivities

Author

Shrestha Bhattarai, Tripti, Shamu, Tambudzai, Gorelick, Alexander N., Chang, Matthew T., Chakravarty, Debyani, Gavrila, Elena I., Donoghue, Mark T. A., Gao, JianJong, Patel, Swati, Gao, Sizhi Paul, Reynolds, Margaret H., Phillips, Sarah M., Soumerai, Tara, Abida, Wassim, Hyman, David M., Schram, Alison M., Solit, David B., Smyth, Lillian M., and Taylor, Barry S.

Published
2022
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9. Pregnancy-associated breast cancer: evaluating maternal and foetal outcomes. A national study

Author

Prior, Lisa, O’Dwyer, Richard, Farooq, Abdul Rehman, Greally, Megan, Ward, Cian, O’Leary, Connor, Aslam, Razia, Darwish, Waseem, Ahmed, Nada, Othman, Elly Che, Watson, Geoffrey, Kelly, Deirdre, Gleeson, Jack, Kiely, Lisa, Hassan, Anees, Walsh, Elaine M., O’Reilly, David, Jones, Alfred, Featherstone, Hannah, Lim, Marvin, Murray, Hazel, Hennessy, Bryan T., Smyth, Lillian M., Leonard, Gregory, Grogan, Liam, Breathnach, Oscar, Calvert, Paula, Horgan, Anne M., Coate, Linda, Jordan, Emmet J., O’Mahony, Deirdre, Gupta, Rajnish, Keane, Maccon M., Westrup, Jennifer, Duffy, Karen, O’Connor, Miriam, Morris, Patrick G., Kennedy, M. John, O’Reilly, Seamus, McCaffrey, John, Kelly, Catherine M., Carney, Desmond, Gullo, Giuseppe, Crown, John, Higgins, Michaela J., Walsh, Paul M., and Walshe, Janice M.

Published
2021
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10. Social Identification and Academic Performance: Integrating Two Existing Models of Tertiary Student Learning

Author

Smyth, Lillian, Mavor, Kenneth I., and Platow, Michael J.

Abstract

Recent research has mapped the ways social identification and normative influence affect students' self-reported learning approaches and course experience, and also, the ways in which social identification and learning approach impact directly on grades. However, there is no evidence for a model incorporating both of these processes. The current paper aims to address this in a dataset drawn from a range of courses and disciplines at a mid-size Australian university. The data capture student demographics, social identification with the field of study, perceived learning norms and learning approaches, and examine how these map onto end of semester academic outcomes. Findings indicate support for the Bliuc identification-to-grade, through learning approach model. Further, we find support for the Smyth identification-by-norm moderation model of predicting learning approaches. Added to which, we find support for a combined moderated mediation model, where the identification-by-norm interaction moderates the indirect effect of identification predicting grades through learning approach. Implications for course design are discussed.

Published
2019
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11. Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS

Author

Rose Brannon, A., Jayakumaran, Gowtham, Diosdado, Monica, Patel, Juber, Razumova, Anna, Hu, Yu, Meng, Fanli, Haque, Mohammad, Sadowska, Justyna, Murphy, Brian J., Baldi, Tessara, Johnson, Ian, Ptashkin, Ryan, Hasan, Maysun, Srinivasan, Preethi, Rema, Anoop Balakrishnan, Rijo, Ivelise, Agarunov, Aaron, Won, Helen, Perera, Dilmi, Brown, David N., Samoila, Aliaksandra, Jing, Xiaohong, Gedvilaite, Erika, Yang, Julie L., Stephens, Dennis P., Dix, Jenna-Marie, DeGroat, Nicole, Nafa, Khedoudja, Syed, Aijazuddin, Li, Alan, Lebow, Emily S., Bowman, Anita S., Ferguson, Donna C., Liu, Ying, Mata, Douglas A., Sharma, Rohit, Yang, Soo-Ryum, Bale, Tejus, Benhamida, Jamal K., Chang, Jason C., Dogan, Snjezana, Hameed, Meera R., Hechtman, Jaclyn F., Moung, Christine, Ross, Dara S., Vakiani, Efsevia, Vanderbilt, Chad M., Yao, JinJuan, Razavi, Pedram, Smyth, Lillian M., Chandarlapaty, Sarat, Iyer, Gopa, Abida, Wassim, Harding, James J., Krantz, Benjamin, O’Reilly, Eileen, Yu, Helena A., Li, Bob T., Rudin, Charles M., Diaz, Luis, Solit, David B., Arcila, Maria E., Ladanyi, Marc, Loomis, Brian, Tsui, Dana, Berger, Michael F., Zehir, Ahmet, and Benayed, Ryma

Published
2021
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12. Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer

Author

Smyth, Lillian M., Batist, Gerald, Meric-Bernstam, Funda, Kabos, Peter, Spanggaard, Iben, Lluch, Ana, Jhaveri, Komal, Varga, Andrea, Wong, Andrea, Schram, Alison M., Ambrose, Helen, Carr, T. Hedley, de Bruin, Elza C., Salinas-Souza, Carolina, Foxley, Andrew, Hauser, Joana, Lindemann, Justin P. O., Maudsley, Rhiannon, McEwen, Robert, Moschetta, Michele, Nikolaou, Myria, Schiavon, Gaia, Razavi, Pedram, Banerji, Udai, Baselga, José, Hyman, David M., and Chandarlapaty, Sarat

Published
2021
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13. A mixed-methods investigation of weight bias reduction in medical students

Author

Rathbone, Joanne A., Smyth, Lillian, and Cruwys, Tegan

Abstract

ABSTRACTWe used a mixed-methods design to test a novel weight bias intervention and understand current attitudes toward people with higher weight and weight-inclusive care among medical students (N = 80). The intervention was embedded in curriculum and uniquely focused on delegitimising the use of weight as a heuristic for health. Almost half of participants (43.8%) responded to both pre- and post-intervention surveys. These participants found the intervention acceptable; and reported significant pre-post reductions in weight bias and endorsement of using weight as a heuristic for health. Less engaged participants reported significantly greater endorsement of using weight as a heuristic for health at pre-intervention. One central theme emerged from pre-intervention qualitative responses, related to how medical students scoped both the problemand the solution. This consisted of three sub-themes: (1) problematizing the system and clinician (and their weight bias), (2) problematizing the patient (who was responsible for their own health), and (3) problematizing the medical condition (weight and health behaviors as problems for the clinician to solve). Participants often showed evidence of several and sometimes contradictory ways of problem-scoping. Problematizing the patient, including weight-stigmatizing assumptions, was particularly pronounced among less engaged participants (i.e. those who did not complete the post-survey). Findings suggest that the intervention may be acceptable and effective in reducing weight bias in medical students who already have lower levels of bias than their peers. Qualitative findings suggest that, even when medical students recognize the harmful impacts of weight stigma and the benefits of weight-inclusive care, approaches to care may remain weight-centric. Together, the findings suggest a key challenge for weight bias reduction among medical students lies in addressing problem-scoping that may encourage weight bias and weight-centric care, and reaching the population most in need of intervention – students with high levels of weight bias.

Published
2024
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14. Learning Behaviour and Learning Outcomes: The Roles for Social Influence and Field of Study

Author

Smyth, Lillian, Mavor, Kenneth I., and Platow, Michael J.

Abstract

Research has demonstrated a significant role of discipline social identification in predicting learning approaches, even controlling for individual differences. Smyth et al. ("Educ Psychol" 35(1):53-72, 2015. doi:10.1080/01443410.2013.822962) suggest that learners share discipline-based social identifications, and that this identification, in combination with relevant norms, influences the adoption of learning approaches. The current paper extends this analysis in two directions. First, the effect of broad field of study is examined for systematic differences across content domains. Secondly, the model examines effects on student perceptions of teaching quality and intentions to continue within a discipline. Results provide support for Smyth et al.'s (2015) model, demonstrating links between discipline identification, perceived norms, learning approaches and outcomes. Strongly identified students, students who perceived deep learning norms and students taking a deep learning approach all reported more positive outcomes. Disciplinary variations in responses to learning approaches and outcomes were also found, broadly in line with that found in the Biglan-Becher literature.

Published
2017
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15. Utility of Serial cfDNA NGS for Prospective Genomic Analysis of Patients on a Phase I Basket Study

Author

Smyth, Lillian M., Reichel, Jonathan B., Tang, Jiabin, Patel, Juber Ahamad A., Meng, Fanli, Selcuklu, Duygu S., Houck-Loomis, Brian, You, Daoqi, Samoila, Aliaksandra, Schiavon, Gaia, Li, Bob T., Razavi, Pedram, Piscuoglio, Salvatore, Reis-Filho, Jorge S., Taylor, Barry S., Baselga, José, Solit, David B., Hyman, David M., Berger, Michael F., and Chandarlapaty, Sarat

Published
2021
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19. Are we teaching the health impacts of climate change in a clinically relevant way? A systematic narrative review of biomechanism-focused climate change learning outcomes in medical curricula.

Author

Sharma, Atul, Smyth, Lillian, Jian, Holly, Vargas, Nicole, Bowles, Devin, and Hunter, Arnagretta

Subjects
*ONLINE information services, *SYSTEMATIC reviews, *CURRICULUM, *DESCRIPTIVE statistics, *BIOMECHANICS, *MEDLINE, *CLIMATE change, *EDUCATIONAL outcomes, *MEDICAL education, *GREY literature, *ERIC (Information retrieval system)
Abstract

Introducing biomedical approaches to the health impacts of climate change can improve medical student engagement with relevant climate-related issues, improve the development of medical schemas, and minimise displacement into crowded medical curricula. This paper aims to systematically review the medical education curricula related to climate change, with a particular focus on systems-based biomechanisms for the health impacts of climate change. We do this to provide a clear agenda for further development of learning outcomes (LOs) in this area to maximize the clinical applicability of this knowledge. A systematic review was undertaken following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA; Liberati et al. 2009) guidelines for both the published and grey literature. Five databases (PubMed, SCOPUS, ERIC, Open Access Thesis and Dissertation, and Proquest Global Dissertation and Theses) were searched for works published between 2011 and June 2023. Full texts that contained LOs were the main inclusion criteria for the final review. Descriptive and content extraction guided the final narrative synthesis. Analysis indicated that biomechanism-related LOs represented about 25% of each published LO set, on average. These outcomes were primarily at the "understand" level of Bloom's taxonomy and were spread across a range of body systems and climate-change aspects. Infectious diseases and extreme heat were strong focuses. Authorship analysis indicated that the majority of these sets of published LOs are from Western contexts and authored by researchers and educators with medical and population health qualifications. Biomechanism-focused teaching about the health impacts of climate change is relatively rare in published curricula. Of the available sets of LOs, the majority are sourced from Western authors and are focused on a fairly circumscribed set of biomedical topics. There is scope to both broaden and deepen curriculum in this area, and we would recommend the field prioritise collaboration with medical educators from the Global South, where the effects of climate change are already the most acutely felt. [ABSTRACT FROM AUTHOR]

Published
2024
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20. How Science Really Works: The Student Experience of Research-Led Education

Author

Smyth, Lillian, Davila, Federico, and Sloan, Thomas

Abstract

There has been a shift in modern tertiary education theory that has moved away from a traditional, didactic model of education, towards a more student-led, constructivist approach. Nowhere is this more the case than in science and mathematical education, where the concept of research-led education is gaining more and more traction. The focus of this approach is on training students to join a community of scholars, rather than on encouraging the accrual of factual knowledge. What has scope to be addressed further in this area is what students might gain from research experience and the impact this kind of education has on career intentions. The current study, using a combination of quantitative and qualitative survey data, explores this experience. We aim to answer questions surrounding skill gains, student perceptions and the impact on career choices. Findings indicate that students value research experience and gain much from it. Further, we find evidence that engaging in, and benefiting from, research experience is related to career intentions. These results have implications for the ways we scaffold research experience for students, as well as reinforcing the value of this approach to education.

Published
2016
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23. Data from Characteristics and Outcome of AKT1E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry

Author

Smyth, Lillian M., primary, Zhou, Qin, primary, Nguyen, Bastien, primary, Yu, Celeste, primary, Lepisto, Eva M., primary, Arnedos, Monica, primary, Hasset, Michael J., primary, Lenoue-Newton, Michele L., primary, Blauvelt, Natalie, primary, Dogan, Semih, primary, Micheel, Christine M., primary, Wathoo, Chetna, primary, Horlings, Hugo, primary, Hudecek, Jan, primary, Gross, Benjamin E., primary, Kundra, Ritika, primary, Sweeney, Shawn M., primary, Gao, JianJiong, primary, Schultz, Nikolaus, primary, Zarski, Andrew, primary, Gardos, Stuart M., primary, Lee, Jocelyn, primary, Sheffler-Collins, Seth, primary, Park, Ben H., primary, Sawyers, Charles L., primary, André, Fabrice, primary, Levy, Mia, primary, Meric-Bernstam, Funda, primary, Bedard, Philippe L., primary, Iasonos, Alexia, primary, Schrag, Deborah, primary, and Hyman, David M., primary

Published
2023
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24. Supplementary Figure S2 from Efficacy and Determinants of Response to HER Kinase Inhibition in HER2-Mutant Metastatic Breast Cancer

Author

Smyth, Lillian M., primary, Piha-Paul, Sarina A., primary, Won, Helen H., primary, Schram, Alison M., primary, Saura, Cristina, primary, Loi, Sherene, primary, Lu, Janice, primary, Shapiro, Geoffrey I., primary, Juric, Dejan, primary, Mayer, Ingrid A., primary, Arteaga, Carlos L., primary, de la Fuente, Macarena I., primary, Brufksy, Adam M., primary, Spanggaard, Iben, primary, Mau-Sørensen, Morten, primary, Arnedos, Monica, primary, Moreno, Victor, primary, Boni, Valentina, primary, Sohn, Joohyuk, primary, Schwartzberg, Lee S., primary, Gonzàlez-Farré, Xavier, primary, Cervantes, Andrés, primary, Bidard, François-Clement, primary, Gorelick, Alexander N., primary, Lanman, Richard B., primary, Nagy, Rebecca J., primary, Ulaner, Gary A., primary, Chandarlapaty, Sarat, primary, Jhaveri, Komal, primary, Gavrila, Elena I., primary, Zimel, Catherine, primary, Selcuklu, S. Duygu, primary, Melcer, Myra, primary, Samoila, Aliaksandra, primary, Cai, Yanyan, primary, Scaltriti, Maurizio, primary, Mann, Grace, primary, Xu, Feng, primary, Eli, Lisa D., primary, Dujka, Melanie, primary, Lalani, Alshad S., primary, Bryce, Richard, primary, Baselga, José, primary, Taylor, Barry S., primary, Solit, David B., primary, Meric-Bernstam, Funda, primary, and Hyman, David M., primary

Published
2023
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25. Data from Efficacy and Determinants of Response to HER Kinase Inhibition in HER2-Mutant Metastatic Breast Cancer

Author

Smyth, Lillian M., primary, Piha-Paul, Sarina A., primary, Won, Helen H., primary, Schram, Alison M., primary, Saura, Cristina, primary, Loi, Sherene, primary, Lu, Janice, primary, Shapiro, Geoffrey I., primary, Juric, Dejan, primary, Mayer, Ingrid A., primary, Arteaga, Carlos L., primary, de la Fuente, Macarena I., primary, Brufksy, Adam M., primary, Spanggaard, Iben, primary, Mau-Sørensen, Morten, primary, Arnedos, Monica, primary, Moreno, Victor, primary, Boni, Valentina, primary, Sohn, Joohyuk, primary, Schwartzberg, Lee S., primary, Gonzàlez-Farré, Xavier, primary, Cervantes, Andrés, primary, Bidard, François-Clement, primary, Gorelick, Alexander N., primary, Lanman, Richard B., primary, Nagy, Rebecca J., primary, Ulaner, Gary A., primary, Chandarlapaty, Sarat, primary, Jhaveri, Komal, primary, Gavrila, Elena I., primary, Zimel, Catherine, primary, Selcuklu, S. Duygu, primary, Melcer, Myra, primary, Samoila, Aliaksandra, primary, Cai, Yanyan, primary, Scaltriti, Maurizio, primary, Mann, Grace, primary, Xu, Feng, primary, Eli, Lisa D., primary, Dujka, Melanie, primary, Lalani, Alshad S., primary, Bryce, Richard, primary, Baselga, José, primary, Taylor, Barry S., primary, Solit, David B., primary, Meric-Bernstam, Funda, primary, and Hyman, David M., primary

Published
2023
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26. Supplementary Table 1 from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion–Driven Cancer

Author

Slotkin, Emily K., primary, Diolaiti, Daniel, primary, Shukla, Neerav N., primary, Dela Cruz, Filemon S., primary, Clark, Jennifer J., primary, Gundem, Gunes, primary, Yellapantula, Venkata D., primary, Levine, Max F., primary, You, Daoqi, primary, Ma, Peilin, primary, Pachhal, Sagarika, primary, Ibanez Sanchez, Glorymar, primary, Benayed, Ryma, primary, Jungbluth, Achim A., primary, Smyth, Lillian M., primary, Mauguen, Audrey, primary, Gushterova, Irena, primary, Ding, Hongxu, primary, Spraggon, Lee, primary, Darnell, Robert, primary, Califano, Andrea, primary, Ladanyi, Marc, primary, Papaemmanuil, Elli, primary, Kung, Andrew L., primary, Hyman, David M., primary, and Roberts, Stephen S., primary

Published
2023
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27. Supplementary Data from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion–Driven Cancer

Author

Slotkin, Emily K., primary, Diolaiti, Daniel, primary, Shukla, Neerav N., primary, Dela Cruz, Filemon S., primary, Clark, Jennifer J., primary, Gundem, Gunes, primary, Yellapantula, Venkata D., primary, Levine, Max F., primary, You, Daoqi, primary, Ma, Peilin, primary, Pachhal, Sagarika, primary, Ibanez Sanchez, Glorymar, primary, Benayed, Ryma, primary, Jungbluth, Achim A., primary, Smyth, Lillian M., primary, Mauguen, Audrey, primary, Gushterova, Irena, primary, Ding, Hongxu, primary, Spraggon, Lee, primary, Darnell, Robert, primary, Califano, Andrea, primary, Ladanyi, Marc, primary, Papaemmanuil, Elli, primary, Kung, Andrew L., primary, Hyman, David M., primary, and Roberts, Stephen S., primary

Published
2023
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28. Supplementary Data from Characteristics and Outcome of AKT1E17K-Mutant Breast Cancer Defined through AACR Project GENIE, a Clinicogenomic Registry

Author

Smyth, Lillian M., primary, Zhou, Qin, primary, Nguyen, Bastien, primary, Yu, Celeste, primary, Lepisto, Eva M., primary, Arnedos, Monica, primary, Hasset, Michael J., primary, Lenoue-Newton, Michele L., primary, Blauvelt, Natalie, primary, Dogan, Semih, primary, Micheel, Christine M., primary, Wathoo, Chetna, primary, Horlings, Hugo, primary, Hudecek, Jan, primary, Gross, Benjamin E., primary, Kundra, Ritika, primary, Sweeney, Shawn M., primary, Gao, JianJiong, primary, Schultz, Nikolaus, primary, Zarski, Andrew, primary, Gardos, Stuart M., primary, Lee, Jocelyn, primary, Sheffler-Collins, Seth, primary, Park, Ben H., primary, Sawyers, Charles L., primary, André, Fabrice, primary, Levy, Mia, primary, Meric-Bernstam, Funda, primary, Bedard, Philippe L., primary, Iasonos, Alexia, primary, Schrag, Deborah, primary, and Hyman, David M., primary

Published
2023
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29. Supplementary Table 2 from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion–Driven Cancer

Author

Slotkin, Emily K., primary, Diolaiti, Daniel, primary, Shukla, Neerav N., primary, Dela Cruz, Filemon S., primary, Clark, Jennifer J., primary, Gundem, Gunes, primary, Yellapantula, Venkata D., primary, Levine, Max F., primary, You, Daoqi, primary, Ma, Peilin, primary, Pachhal, Sagarika, primary, Ibanez Sanchez, Glorymar, primary, Benayed, Ryma, primary, Jungbluth, Achim A., primary, Smyth, Lillian M., primary, Mauguen, Audrey, primary, Gushterova, Irena, primary, Ding, Hongxu, primary, Spraggon, Lee, primary, Darnell, Robert, primary, Califano, Andrea, primary, Ladanyi, Marc, primary, Papaemmanuil, Elli, primary, Kung, Andrew L., primary, Hyman, David M., primary, and Roberts, Stephen S., primary

Published
2023
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30. Data from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion–Driven Cancer

Author

Slotkin, Emily K., primary, Diolaiti, Daniel, primary, Shukla, Neerav N., primary, Dela Cruz, Filemon S., primary, Clark, Jennifer J., primary, Gundem, Gunes, primary, Yellapantula, Venkata D., primary, Levine, Max F., primary, You, Daoqi, primary, Ma, Peilin, primary, Pachhal, Sagarika, primary, Ibanez Sanchez, Glorymar, primary, Benayed, Ryma, primary, Jungbluth, Achim A., primary, Smyth, Lillian M., primary, Mauguen, Audrey, primary, Gushterova, Irena, primary, Ding, Hongxu, primary, Spraggon, Lee, primary, Darnell, Robert, primary, Califano, Andrea, primary, Ladanyi, Marc, primary, Papaemmanuil, Elli, primary, Kung, Andrew L., primary, Hyman, David M., primary, and Roberts, Stephen S., primary

Published
2023
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31. Supplementary Data from Efficacy and Determinants of Response to HER Kinase Inhibition in HER2-Mutant Metastatic Breast Cancer

Author

Smyth, Lillian M., primary, Piha-Paul, Sarina A., primary, Won, Helen H., primary, Schram, Alison M., primary, Saura, Cristina, primary, Loi, Sherene, primary, Lu, Janice, primary, Shapiro, Geoffrey I., primary, Juric, Dejan, primary, Mayer, Ingrid A., primary, Arteaga, Carlos L., primary, de la Fuente, Macarena I., primary, Brufksy, Adam M., primary, Spanggaard, Iben, primary, Mau-Sørensen, Morten, primary, Arnedos, Monica, primary, Moreno, Victor, primary, Boni, Valentina, primary, Sohn, Joohyuk, primary, Schwartzberg, Lee S., primary, Gonzàlez-Farré, Xavier, primary, Cervantes, Andrés, primary, Bidard, François-Clement, primary, Gorelick, Alexander N., primary, Lanman, Richard B., primary, Nagy, Rebecca J., primary, Ulaner, Gary A., primary, Chandarlapaty, Sarat, primary, Jhaveri, Komal, primary, Gavrila, Elena I., primary, Zimel, Catherine, primary, Selcuklu, S. Duygu, primary, Melcer, Myra, primary, Samoila, Aliaksandra, primary, Cai, Yanyan, primary, Scaltriti, Maurizio, primary, Mann, Grace, primary, Xu, Feng, primary, Eli, Lisa D., primary, Dujka, Melanie, primary, Lalani, Alshad S., primary, Bryce, Richard, primary, Baselga, José, primary, Taylor, Barry S., primary, Solit, David B., primary, Meric-Bernstam, Funda, primary, and Hyman, David M., primary

Published
2023
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32. Supplementary Methods from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion–Driven Cancer

Author

Slotkin, Emily K., primary, Diolaiti, Daniel, primary, Shukla, Neerav N., primary, Dela Cruz, Filemon S., primary, Clark, Jennifer J., primary, Gundem, Gunes, primary, Yellapantula, Venkata D., primary, Levine, Max F., primary, You, Daoqi, primary, Ma, Peilin, primary, Pachhal, Sagarika, primary, Ibanez Sanchez, Glorymar, primary, Benayed, Ryma, primary, Jungbluth, Achim A., primary, Smyth, Lillian M., primary, Mauguen, Audrey, primary, Gushterova, Irena, primary, Ding, Hongxu, primary, Spraggon, Lee, primary, Darnell, Robert, primary, Califano, Andrea, primary, Ladanyi, Marc, primary, Papaemmanuil, Elli, primary, Kung, Andrew L., primary, Hyman, David M., primary, and Roberts, Stephen S., primary

Published
2023
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33. Supplementary Table 4 from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion–Driven Cancer

Author

Slotkin, Emily K., primary, Diolaiti, Daniel, primary, Shukla, Neerav N., primary, Dela Cruz, Filemon S., primary, Clark, Jennifer J., primary, Gundem, Gunes, primary, Yellapantula, Venkata D., primary, Levine, Max F., primary, You, Daoqi, primary, Ma, Peilin, primary, Pachhal, Sagarika, primary, Ibanez Sanchez, Glorymar, primary, Benayed, Ryma, primary, Jungbluth, Achim A., primary, Smyth, Lillian M., primary, Mauguen, Audrey, primary, Gushterova, Irena, primary, Ding, Hongxu, primary, Spraggon, Lee, primary, Darnell, Robert, primary, Califano, Andrea, primary, Ladanyi, Marc, primary, Papaemmanuil, Elli, primary, Kung, Andrew L., primary, Hyman, David M., primary, and Roberts, Stephen S., primary

Published
2023
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34. Supplementary Table 5 from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion–Driven Cancer

Author

Slotkin, Emily K., primary, Diolaiti, Daniel, primary, Shukla, Neerav N., primary, Dela Cruz, Filemon S., primary, Clark, Jennifer J., primary, Gundem, Gunes, primary, Yellapantula, Venkata D., primary, Levine, Max F., primary, You, Daoqi, primary, Ma, Peilin, primary, Pachhal, Sagarika, primary, Ibanez Sanchez, Glorymar, primary, Benayed, Ryma, primary, Jungbluth, Achim A., primary, Smyth, Lillian M., primary, Mauguen, Audrey, primary, Gushterova, Irena, primary, Ding, Hongxu, primary, Spraggon, Lee, primary, Darnell, Robert, primary, Califano, Andrea, primary, Ladanyi, Marc, primary, Papaemmanuil, Elli, primary, Kung, Andrew L., primary, Hyman, David M., primary, and Roberts, Stephen S., primary

Published
2023
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35. Supplementary Table 3 from Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion–Driven Cancer

Author

Slotkin, Emily K., primary, Diolaiti, Daniel, primary, Shukla, Neerav N., primary, Dela Cruz, Filemon S., primary, Clark, Jennifer J., primary, Gundem, Gunes, primary, Yellapantula, Venkata D., primary, Levine, Max F., primary, You, Daoqi, primary, Ma, Peilin, primary, Pachhal, Sagarika, primary, Ibanez Sanchez, Glorymar, primary, Benayed, Ryma, primary, Jungbluth, Achim A., primary, Smyth, Lillian M., primary, Mauguen, Audrey, primary, Gushterova, Irena, primary, Ding, Hongxu, primary, Spraggon, Lee, primary, Darnell, Robert, primary, Califano, Andrea, primary, Ladanyi, Marc, primary, Papaemmanuil, Elli, primary, Kung, Andrew L., primary, Hyman, David M., primary, and Roberts, Stephen S., primary

Published
2023
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36. Discipline Social Identification, Study Norms and Learning Approach in University Students

Author

Smyth, Lillian, Mavor, Kenneth I., Platow, Michael J., Grace, Diana M., and Reynolds, Katherine J.

Abstract

Adopting a deep approach to learning is associated with positive academic outcomes. In the current paper, we extend this analysis in a university context by recognising that learners are not isolated individuals, but share important social identifications with others. Using online surveys at an Australian university, we examine the effects of discipline social identification and educational norms on the adoption of learning approaches. Students from a range of academic disciplines indicated their social identification with their discipline, their perceptions of peer norms within their discipline of study, and what their own learning approaches were. Results demonstrate a significant role of discipline-related social identification in predicting learning approaches, even after controlling for personal factors and quality of teaching. Moreover, perceived norms moderated this effect. Students' approaches to learning are affected not simply by their salient self-concepts, but by their salient "discipline-related" self-concepts and the norms embodied in the learning environment.

Published
2015
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37. Supplementary Figure from Natural History and Characteristics of ERBB2-mutated Hormone Receptor–positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case–control Study from AACR Project GENIE

Author

LeNoue-Newton, Michele L., primary, Chen, Sheau-Chiann, primary, Stricker, Thomas, primary, Hyman, David M., primary, Blauvelt, Natalie, primary, Bedard, Philippe L., primary, Meric-Bernstam, Funda, primary, Punglia, Rinaa S., primary, Schrag, Deborah, primary, Lepisto, Eva M., primary, Andre, Fabrice, primary, Smyth, Lillian, primary, Dogan, Semih, primary, Yu, Celeste, primary, Wathoo, Chetna, primary, Levy, Mia, primary, Eli, Lisa D., primary, Xu, Feng, primary, Mann, Grace, primary, Lalani, Alshad S., primary, Ye, Fei, primary, Micheel, Christine M., primary, and Arnedos, Monica, primary

Published
2023
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38. Supplementary Table from Natural History and Characteristics of ERBB2-mutated Hormone Receptor–positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case–control Study from AACR Project GENIE

Author

LeNoue-Newton, Michele L., primary, Chen, Sheau-Chiann, primary, Stricker, Thomas, primary, Hyman, David M., primary, Blauvelt, Natalie, primary, Bedard, Philippe L., primary, Meric-Bernstam, Funda, primary, Punglia, Rinaa S., primary, Schrag, Deborah, primary, Lepisto, Eva M., primary, Andre, Fabrice, primary, Smyth, Lillian, primary, Dogan, Semih, primary, Yu, Celeste, primary, Wathoo, Chetna, primary, Levy, Mia, primary, Eli, Lisa D., primary, Xu, Feng, primary, Mann, Grace, primary, Lalani, Alshad S., primary, Ye, Fei, primary, Micheel, Christine M., primary, and Arnedos, Monica, primary

Published
2023
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39. Supplementary Figure 3 from Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with AKT1E17K-Mutant, ER-Positive Metastatic Breast Cancer

Author

Smyth, Lillian M., primary, Tamura, Kenji, primary, Oliveira, Mafalda, primary, Ciruelos, Eva M., primary, Mayer, Ingrid A., primary, Sablin, Marie-Paule, primary, Biganzoli, Laura, primary, Ambrose, Helen J., primary, Ashton, Jack, primary, Barnicle, Alan, primary, Cashell, Des D., primary, Corcoran, Claire, primary, de Bruin, Elza C., primary, Foxley, Andrew, primary, Hauser, Joana, primary, Lindemann, Justin P.O., primary, Maudsley, Rhiannon, primary, McEwen, Robert, primary, Moschetta, Michele, primary, Pass, Martin, primary, Rowlands, Vicky, primary, Schiavon, Gaia, primary, Banerji, Udai, primary, Scaltriti, Maurizio, primary, Taylor, Barry S., primary, Chandarlapaty, Sarat, primary, Baselga, José, primary, and Hyman, David M., primary

Published
2023
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40. Supplementary Figure 1 from Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with AKT1E17K-Mutant, ER-Positive Metastatic Breast Cancer

Author

Smyth, Lillian M., primary, Tamura, Kenji, primary, Oliveira, Mafalda, primary, Ciruelos, Eva M., primary, Mayer, Ingrid A., primary, Sablin, Marie-Paule, primary, Biganzoli, Laura, primary, Ambrose, Helen J., primary, Ashton, Jack, primary, Barnicle, Alan, primary, Cashell, Des D., primary, Corcoran, Claire, primary, de Bruin, Elza C., primary, Foxley, Andrew, primary, Hauser, Joana, primary, Lindemann, Justin P.O., primary, Maudsley, Rhiannon, primary, McEwen, Robert, primary, Moschetta, Michele, primary, Pass, Martin, primary, Rowlands, Vicky, primary, Schiavon, Gaia, primary, Banerji, Udai, primary, Scaltriti, Maurizio, primary, Taylor, Barry S., primary, Chandarlapaty, Sarat, primary, Baselga, José, primary, and Hyman, David M., primary

Published
2023
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41. Supplementary Figure 2 from Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with AKT1E17K-Mutant, ER-Positive Metastatic Breast Cancer

Author

Smyth, Lillian M., primary, Tamura, Kenji, primary, Oliveira, Mafalda, primary, Ciruelos, Eva M., primary, Mayer, Ingrid A., primary, Sablin, Marie-Paule, primary, Biganzoli, Laura, primary, Ambrose, Helen J., primary, Ashton, Jack, primary, Barnicle, Alan, primary, Cashell, Des D., primary, Corcoran, Claire, primary, de Bruin, Elza C., primary, Foxley, Andrew, primary, Hauser, Joana, primary, Lindemann, Justin P.O., primary, Maudsley, Rhiannon, primary, McEwen, Robert, primary, Moschetta, Michele, primary, Pass, Martin, primary, Rowlands, Vicky, primary, Schiavon, Gaia, primary, Banerji, Udai, primary, Scaltriti, Maurizio, primary, Taylor, Barry S., primary, Chandarlapaty, Sarat, primary, Baselga, José, primary, and Hyman, David M., primary

Published
2023
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42. Supplementary Material from Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with AKT1E17K-Mutant, ER-Positive Metastatic Breast Cancer

Author

Smyth, Lillian M., primary, Tamura, Kenji, primary, Oliveira, Mafalda, primary, Ciruelos, Eva M., primary, Mayer, Ingrid A., primary, Sablin, Marie-Paule, primary, Biganzoli, Laura, primary, Ambrose, Helen J., primary, Ashton, Jack, primary, Barnicle, Alan, primary, Cashell, Des D., primary, Corcoran, Claire, primary, de Bruin, Elza C., primary, Foxley, Andrew, primary, Hauser, Joana, primary, Lindemann, Justin P.O., primary, Maudsley, Rhiannon, primary, McEwen, Robert, primary, Moschetta, Michele, primary, Pass, Martin, primary, Rowlands, Vicky, primary, Schiavon, Gaia, primary, Banerji, Udai, primary, Scaltriti, Maurizio, primary, Taylor, Barry S., primary, Chandarlapaty, Sarat, primary, Baselga, José, primary, and Hyman, David M., primary

Published
2023
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43. Data from Natural History and Characteristics of ERBB2-mutated Hormone Receptor–positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case–control Study from AACR Project GENIE

Author

LeNoue-Newton, Michele L., primary, Chen, Sheau-Chiann, primary, Stricker, Thomas, primary, Hyman, David M., primary, Blauvelt, Natalie, primary, Bedard, Philippe L., primary, Meric-Bernstam, Funda, primary, Punglia, Rinaa S., primary, Schrag, Deborah, primary, Lepisto, Eva M., primary, Andre, Fabrice, primary, Smyth, Lillian, primary, Dogan, Semih, primary, Yu, Celeste, primary, Wathoo, Chetna, primary, Levy, Mia, primary, Eli, Lisa D., primary, Xu, Feng, primary, Mann, Grace, primary, Lalani, Alshad S., primary, Ye, Fei, primary, Micheel, Christine M., primary, and Arnedos, Monica, primary

Published
2023
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44. Abstract OT1-01-02: EMBER-4: A phase 3 adjuvant trial of imlunestrant vs standard endocrine therapy (ET) in patients with ER+, HER2- early breast cancer (EBC) with an increased risk of recurrence who have previously received 2 to 5 years of adjuvant ET

Author

Jhaveri, Komal, primary, O’Shaughnessy, Joyce, additional, Andre, Fabrice, additional, Goetz, Matthew P., additional, Harbeck, Nadia, additional, Martín, Miguel, additional, Bidard, Francois-Clement, additional, Thomas, Zachary M., additional, Young, Suzanne, additional, Ismail-Khan, Roohi, additional, Smyth, Lillian M., additional, and Gnant, Michael, additional

Published
2023
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45. Abstract OT3-08-01: A phase 1 trial of LOXO-783, a potent, highly mutant-selective, brain-penetrant allosteric PI3Kα H1047R inhibitor in PIK3CA H1047R-mutant advanced breast cancer (aBC) and other solid tumors (PIKASSO-01, trial in progress)

Author

Juric, Dejan, primary, Jhaveri, Komal, additional, Beeram, Muralidhar, additional, Hamilton, Erika, additional, Chau, Vincent, additional, Hanley, Matthew P., additional, Liu, Shiyao, additional, Smyth, Lillian M., additional, and Meric-Bernstam, Funda, additional

Published
2023
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46. Abstract P4-08-02: LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models

Author

Puca, Loredana, primary, Dowless, Michele S., additional, Perez-Ferreiro, Carmen M., additional, Ortiz-Ruiz, Maria Jesus, additional, Donoho, Gregory P., additional, Capen, Andrew, additional, Huber, Lysiane, additional, Bogner, Sarah M., additional, Fei, Dongling, additional, Manro, Jason R., additional, Yu, Chun Ping, additional, Xu, Wei Guo, additional, Wang, Rui, additional, Chen, Shuang, additional, Hicks, Mark A., additional, Zolfaghari, Parisa, additional, Faber, Andrew, additional, Gilmour, Raymond, additional, Ramstetter, Monica D., additional, Chang, Matthew T., additional, Lallena, Maria Jose, additional, Gong, Xuequian, additional, Hyman, David M., additional, Smyth, Lillian M., additional, Brandhuber, Barbara J., additional, Taylor, Barry S., additional, and Klippel, Anke, additional

Published
2023
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47. A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel

Author

Smyth, Lillian M., Monson, Kelsey R., Jhaveri, Komal, Drilon, Alexander, Li, Bob T., Abida, Wassim, Iyer, Gopa, Gerecitano, John F., Gounder, Mrinal, Harding, James J., Voss, Martin H., Makker, Vicky, Ho, Alan L., Razavi, Pedram, Iasonos, Alexia, Bialer, Philip, Lacouture, Mario E., Teitcher, Jerrold B., Erinjeri, Joseph P., Katabi, Nora, Fury, Matthew G., and Hyman, David M.

Published
2017
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49. Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers

Author

Hyman, David M., Piha-Paul, Sarina A., Won, Helen, Rodon, Jordi, Saura, Cristina, Shapiro, Geoffrey I., Juric, Dejan, Quinn, David I., Moreno, Victor, Doger, Bernard, Mayer, Ingrid A., Boni, Valentina, Calvo, Emiliano, Loi, Sherene, Lockhart, Albert C., Erinjeri, Joseph P., Scaltriti, Maurizio, Ulaner, Gary A., Patel, Juber, Tang, Jiabin, Beer, Hannah, Selcuklu, S. Duygu, Hanrahan, Aphrothiti J., Bouvier, Nancy, Melcer, Myra, Murali, Rajmohan, Schram, Alison M., Smyth, Lillian M., Jhaveri, Komal, Li, Bob T., Drilon, Alexander, Harding, James J., Iyer, Gopa, Taylor, Barry S., Berger, Michael F., Cutler, Jr, Richard E., Xu, Feng, Butturini, Anna, Eli, Lisa D., Mann, Grace, Farrell, Cynthia, Lalani, Alshad S., Bryce, Richard P., Arteaga, Carlos L., Meric-Bernstam, Funda, Baselga, José, and Solit, David B.

Published
2019
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