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3. Supplementary Figure 5 from WWOX Gene Expression Abolishes Ovarian Cancer Tumorigenicity In vivo and Decreases Attachment to Fibronectin via Integrin α3

Author

Gourley, Charlie, primary, Paige, Adam J.W., primary, Taylor, Karen J., primary, Ward, Carol, primary, Kuske, Barbara, primary, Zhang, Jieqing, primary, Sun, Mingjun, primary, Janczar, Szymon, primary, Harrison, David J., primary, Muir, Morwenna, primary, Smyth, John F., primary, and Gabra, Hani, primary

Published
2023
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4. Data from A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Author

Kulbe, Hagen, primary, Chakravarty, Probir, primary, Leinster, D. Andrew, primary, Charles, Kellie A., primary, Kwong, Joseph, primary, Thompson, Richard G., primary, Coward, Jermaine I., primary, Schioppa, Tiziana, primary, Robinson, Stephen C., primary, Gallagher, William M., primary, Galletta, Laura, primary, Salako, Michael A., primary, Smyth, John F., primary, Hagemann, Thorsten, primary, Brennan, Donal J., primary, Bowtell, David D., primary, and Balkwill, Frances R., primary

Published
2023
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5. Supplementary Methods, Legends for Figures 1-5 from WWOX Gene Expression Abolishes Ovarian Cancer Tumorigenicity In vivo and Decreases Attachment to Fibronectin via Integrin α3

Author

Gourley, Charlie, primary, Paige, Adam J.W., primary, Taylor, Karen J., primary, Ward, Carol, primary, Kuske, Barbara, primary, Zhang, Jieqing, primary, Sun, Mingjun, primary, Janczar, Szymon, primary, Harrison, David J., primary, Muir, Morwenna, primary, Smyth, John F., primary, and Gabra, Hani, primary

Published
2023
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6. Supplementary Figure 3 from WWOX Gene Expression Abolishes Ovarian Cancer Tumorigenicity In vivo and Decreases Attachment to Fibronectin via Integrin α3

Author

Gourley, Charlie, primary, Paige, Adam J.W., primary, Taylor, Karen J., primary, Ward, Carol, primary, Kuske, Barbara, primary, Zhang, Jieqing, primary, Sun, Mingjun, primary, Janczar, Szymon, primary, Harrison, David J., primary, Muir, Morwenna, primary, Smyth, John F., primary, and Gabra, Hani, primary

Published
2023
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7. Supplementary Table 2 from A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Author

Kulbe, Hagen, primary, Chakravarty, Probir, primary, Leinster, D. Andrew, primary, Charles, Kellie A., primary, Kwong, Joseph, primary, Thompson, Richard G., primary, Coward, Jermaine I., primary, Schioppa, Tiziana, primary, Robinson, Stephen C., primary, Gallagher, William M., primary, Galletta, Laura, primary, Salako, Michael A., primary, Smyth, John F., primary, Hagemann, Thorsten, primary, Brennan, Donal J., primary, Bowtell, David D., primary, and Balkwill, Frances R., primary

Published
2023
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8. Supplementary Figure 4 from WWOX Gene Expression Abolishes Ovarian Cancer Tumorigenicity In vivo and Decreases Attachment to Fibronectin via Integrin α3

Author

Gourley, Charlie, primary, Paige, Adam J.W., primary, Taylor, Karen J., primary, Ward, Carol, primary, Kuske, Barbara, primary, Zhang, Jieqing, primary, Sun, Mingjun, primary, Janczar, Szymon, primary, Harrison, David J., primary, Muir, Morwenna, primary, Smyth, John F., primary, and Gabra, Hani, primary

Published
2023
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9. Supplementary Figure Legends 1-4 from A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Author

Kulbe, Hagen, primary, Chakravarty, Probir, primary, Leinster, D. Andrew, primary, Charles, Kellie A., primary, Kwong, Joseph, primary, Thompson, Richard G., primary, Coward, Jermaine I., primary, Schioppa, Tiziana, primary, Robinson, Stephen C., primary, Gallagher, William M., primary, Galletta, Laura, primary, Salako, Michael A., primary, Smyth, John F., primary, Hagemann, Thorsten, primary, Brennan, Donal J., primary, Bowtell, David D., primary, and Balkwill, Frances R., primary

Published
2023
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10. Supplementary Figure 2 from WWOX Gene Expression Abolishes Ovarian Cancer Tumorigenicity In vivo and Decreases Attachment to Fibronectin via Integrin α3

Author

Gourley, Charlie, primary, Paige, Adam J.W., primary, Taylor, Karen J., primary, Ward, Carol, primary, Kuske, Barbara, primary, Zhang, Jieqing, primary, Sun, Mingjun, primary, Janczar, Szymon, primary, Harrison, David J., primary, Muir, Morwenna, primary, Smyth, John F., primary, and Gabra, Hani, primary

Published
2023
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11. Supplementary Figure 3 from A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Author

Kulbe, Hagen, primary, Chakravarty, Probir, primary, Leinster, D. Andrew, primary, Charles, Kellie A., primary, Kwong, Joseph, primary, Thompson, Richard G., primary, Coward, Jermaine I., primary, Schioppa, Tiziana, primary, Robinson, Stephen C., primary, Gallagher, William M., primary, Galletta, Laura, primary, Salako, Michael A., primary, Smyth, John F., primary, Hagemann, Thorsten, primary, Brennan, Donal J., primary, Bowtell, David D., primary, and Balkwill, Frances R., primary

Published
2023
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12. Supplementary Table 1 from A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Author

Kulbe, Hagen, primary, Chakravarty, Probir, primary, Leinster, D. Andrew, primary, Charles, Kellie A., primary, Kwong, Joseph, primary, Thompson, Richard G., primary, Coward, Jermaine I., primary, Schioppa, Tiziana, primary, Robinson, Stephen C., primary, Gallagher, William M., primary, Galletta, Laura, primary, Salako, Michael A., primary, Smyth, John F., primary, Hagemann, Thorsten, primary, Brennan, Donal J., primary, Bowtell, David D., primary, and Balkwill, Frances R., primary

Published
2023
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13. Supplementary Figure 4 from A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Author

Kulbe, Hagen, primary, Chakravarty, Probir, primary, Leinster, D. Andrew, primary, Charles, Kellie A., primary, Kwong, Joseph, primary, Thompson, Richard G., primary, Coward, Jermaine I., primary, Schioppa, Tiziana, primary, Robinson, Stephen C., primary, Gallagher, William M., primary, Galletta, Laura, primary, Salako, Michael A., primary, Smyth, John F., primary, Hagemann, Thorsten, primary, Brennan, Donal J., primary, Bowtell, David D., primary, and Balkwill, Frances R., primary

Published
2023
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15. Supplementary Figure 2 from A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Author

Kulbe, Hagen, primary, Chakravarty, Probir, primary, Leinster, D. Andrew, primary, Charles, Kellie A., primary, Kwong, Joseph, primary, Thompson, Richard G., primary, Coward, Jermaine I., primary, Schioppa, Tiziana, primary, Robinson, Stephen C., primary, Gallagher, William M., primary, Galletta, Laura, primary, Salako, Michael A., primary, Smyth, John F., primary, Hagemann, Thorsten, primary, Brennan, Donal J., primary, Bowtell, David D., primary, and Balkwill, Frances R., primary

Published
2023
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16. Supplementary Figure 1 from WWOX Gene Expression Abolishes Ovarian Cancer Tumorigenicity In vivo and Decreases Attachment to Fibronectin via Integrin α3

Author

Gourley, Charlie, primary, Paige, Adam J.W., primary, Taylor, Karen J., primary, Ward, Carol, primary, Kuske, Barbara, primary, Zhang, Jieqing, primary, Sun, Mingjun, primary, Janczar, Szymon, primary, Harrison, David J., primary, Muir, Morwenna, primary, Smyth, John F., primary, and Gabra, Hani, primary

Published
2023
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17. Supplementary Figure 1 from A Dynamic Inflammatory Cytokine Network in the Human Ovarian Cancer Microenvironment

Author

Kulbe, Hagen, primary, Chakravarty, Probir, primary, Leinster, D. Andrew, primary, Charles, Kellie A., primary, Kwong, Joseph, primary, Thompson, Richard G., primary, Coward, Jermaine I., primary, Schioppa, Tiziana, primary, Robinson, Stephen C., primary, Gallagher, William M., primary, Galletta, Laura, primary, Salako, Michael A., primary, Smyth, John F., primary, Hagemann, Thorsten, primary, Brennan, Donal J., primary, Bowtell, David D., primary, and Balkwill, Frances R., primary

Published
2023
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23. The tumor-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans

Author

Charles, Kellie A., Kulbe, Hagen, Soper, Robin, Escorcio-Correia, Monica, Lawrence, Toby, Schultheis, Anne, Chakravarty, Probir, Thompson, Richard G., Kollias, George, Smyth, John F., Balkwill, Frances R., and Hagemann, Thorsten

Subjects
Tumor necrosis factor -- Properties, Interleukins -- Properties, Ovarian cancer -- Development and progression -- Care and treatment, Health care industry
Abstract

Cytokines orchestrate the tumor-promoting interplay between malignant cells and the immune system. In many experimental and human cancers, the cytokine TNF-α is an important component of this interplay, but its effects are pleiotropic and therefore remain to be completely defined. Using a mouse model of ovarian cancer in which either TNF receptor 1 (TNFR1) signaling was manipulated in different leukocyte populations or TNF-α was neutralized by antibody treatment, we found that this inflammatory cytokine maintained TNFR1-dependent IL-17 production by [CD4.sup.+] cells and that this led to myeloid cell recruitment into the tumor microenvironment and enhanced tumor growth. Consistent with this, in patients with advanced cancer, treatment with the TNF-α-specific antibody infliximab substantially reduced plasma IL-17 levels. Furthermore, expression of IL-1R and IL-23R was downregulated in [CD4.sup.+][CD25.sup.-] cells isolated from ascites of ovarian cancer patients treated with infliximab. We have also shown that genes ascribed to the Th17 pathway map closely with the TNF-α signaling pathway in ovarian cancer biopsy samples, showing particularly high levels of expression of genes encoding IL-23, components of the NF-κB system, TGF-β1, and proteins involved in neutrophil activation. We conclude that chronic production of TNF-α in the tumor microenvironment increases myeloid cell recruitment in an IL-17-dependent manner that contributes to the tumor-promoting action of this proinflammatory cytokine., Introduction The tumor microenvironment generates a complex cytokine network that influences malignant cell proliferation, metastasis, angiogenesis, and the composition of the leukocyte infiltrate. This cytokine network also subverts adaptive immunity [...]

Published
2009
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45. Euro Exams

Author

Petch, M. C. and Smyth, John F.

Published
1992

48. WWOX: A candidate tumor suppressor gene involved in multiple tumor types

Author

Paige, Adam J. W., Taylor, Karen J., Taylor, Claire, Hillier, Stephen G., Farrington, Susan, Scott, Diane, Porteous, David J., Smyth, John F., Gabra, Hani, and Watson, J. E. Vivienne

Subjects
Tumor suppressor genes -- Research, Ovarian cancer -- Genetic aspects, Science and technology
Abstract

We previously reported the construction of a P1-derived artificial chromosome (PAC) contig encompassing a set of homozygous deletions of chromosome 16q23-24.1 found in primary ovarian tumor material and several tumor cell lines. Using these PAC clones in a cDNA selection experiment, we have isolated a Sau3A fragment homologous to the WWOX transcript (GenBank accession no. AF211943) from normal human ovarian surface epithelial (HOSE) cells. We demonstrate the homozygous deletion of WWOX exons from ovarian cancer cells and three different tumor cell lines. We also identify an internally deleted WWOX transcript from a further primary ovarian tumor. In three of these samples the deletions result in frameshifts, and in each case the resulting WWOX transcripts lack part, or all, of the short chain dehydrogenase domain and the putative mitochondrial localization signal. Sequencing revealed several missense polymorphisms in tumor cell lines and identified a high level of single nucleotide polymorphism (SNP) within the WWOX gene. This evidence strengthens the case for WWOX as a tumor suppressor gene in ovarian cancer and other tumor types.

Published
2001

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