Search

Your search keyword '"Smj Searle"' showing total 2 results
Start Over Author "Smj Searle"
2 results on '"Smj Searle"'

1. [Untitled]

Author

Christopher J. Mungall, Jonathan L. Tupy, Joshua S. Kaminker, Colin Wiel, Leyla Bayraktaroglu, Madeline A. Crosby, Vivek Iyer, J. Richter, Suzanna E. Lewis, Gerald M. Rubin, M Gibson, Michele Clamp, Sima Misra, Christopher D. Smith, Smj Searle, Simon Prochnik, Nomi L. Harris, Beverley B. Matthews, and Ewan Birney

Subjects
0106 biological sciences, 0303 health sciences, Information retrieval, Point (typography), biology, Apollo, Genome project, Computational biology, biology.organism_classification, 01 natural sciences, Genome, 03 medical and health sciences, Annotation, ComputingMethodologies_PATTERNRECOGNITION, Sequence annotation, Software design, FlyBase : A Database of Drosophila Genes & Genomes, 030304 developmental biology, 010606 plant biology & botany
Abstract

The well-established inaccuracy of purely computational methods for annotating genome sequences necessitates an interactive tool to allow biological experts to refine these approximations by viewing and independently evaluating the data supporting each annotation. Apollo was developed to meet this need, enabling curators to inspect genome annotations closely and edit them. FlyBase biologists successfully used Apollo to annotate the Drosophila melanogaster genome and it is increasingly being used as a starting point for the development of customized annotation editing tools for other genome projects.

Published
2002
Full Text
View/download PDF

2. The sheep genome illuminates biology of the rumen and lipid metabolism.

Author

Jiang Y, Xie M, Chen W, Talbot R, Maddox JF, Faraut T, Wu C, Muzny DM, Li Y, Zhang W, Stanton JA, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SMJ, Adelson DL, Bian C, Cam GR, Chen Y, Cheng S, DeSilva U, Dixen K, Dong Y, Fan G, Franklin IR, Fu S, Guan R, Highland MA, Holder ME, Huang G, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu W, Liu X, Lu C, Lv T, Mathew T, McWilliam S, Menzies M, Pan S, Robelin D, Servin B, Townley D, Wang W, Wei B, White SN, Yang X, Ye C, Yue Y, Zeng P, Zhou Q, Hansen JB, Kristensen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas J, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W, and Dalrymple BP

Subjects
Amino Acid Sequence, Animals, Fatty Acids, Volatile metabolism, Fatty Acids, Volatile physiology, Gene Expression Regulation, Genome, Keratins, Hair-Specific genetics, Lipid Metabolism genetics, Molecular Sequence Data, Phylogeny, Rumen metabolism, Sheep, Domestic classification, Transcriptome, Wool growth & development, Lipid Metabolism physiology, Rumen physiology, Sheep, Domestic genetics, Sheep, Domestic metabolism
Abstract

Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals., (Copyright © 2014, American Association for the Advancement of Science.)

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results