Search

Your search keyword '"Smits, F Jasmijn"' showing total 38 results
Start Over Author "Smits, F Jasmijn"
38 results on '"Smits, F Jasmijn"'

1. Algorithm-based care versus usual care for the early recognition and management of complications after pancreatic resection in the Netherlands: an open-label, nationwide, stepped-wedge cluster-randomised trial

Author

Blomjous, JG, de Boer, MT, van den Boezem, P, Bouwense, S, Bruijnen, R, Buis, CI, del Chiaro, M, Coene, PP, Coolsen, M, Daams, F, Dejong, K, Draaisma, W, Eker, HH, Elsen, AH, Gerhards, MF, Hartog, H, Hoogwater, FJ, Imani, F, Jenniskens, S, de Jong, KP, Karsten, TM, Klaase, JM, de Kleine, RHJ, van Laarhoven, CJ, van der Lelij, H, Manusama, ER, Meerdink, M, Meijerink, M, Nederend, J, Nijkamp, MW, Nota, CL, Porte, RJ, Reef, J, de Reuver, P, van Rijswijk, C, Romkens, T, Rupert, C, van der Schelling, GP, Serafino, JP, Vos, LD, Vriens, MR, Beers-Vural, E, Wagtenberg, JM, Wijsman, JH, de Wilde, RF, Wolfgang, CL, Zeh, HJ, III, Smits, F Jasmijn, Henry, Anne Claire, Besselink, Marc G, Busch, Olivier R, van Eijck, Casper H, Arntz, Mark, Bollen, Thomas L, van Delden, Otto M, van den Heuvel, Daniel, van der Leij, Christiaan, van Lienden, Krijn P, Moelker, Adriaan, Bonsing, Bert A, Borel Rinkes, Inne H, Bosscha, Koop, van Dam, Ronald M, Derksen, Wouter J M, den Dulk, Marcel, Festen, Sebastiaan, Groot Koerkamp, Bas, de Haas, Robbert J, Hagendoorn, Jeroen, van der Harst, Erwin, de Hingh, Ignace H, Kazemier, Geert, van der Kolk, Marion, Liem, Mike, Lips, Daan J, Luyer, Misha D, de Meijer, Vincent E, Mieog, J Sven, Nieuwenhuijs, Vincent B, Patijn, Gijs A, te Riele, Wouter W, Roos, Daphne, Schreinemakers, Jennifer M, Stommel, Martijn W J, Wit, Fennie, Zonderhuis, Babs A, Daamen, Lois A, van Werkhoven, C Henri, Molenaar, I Quintus, and van Santvoort, Hjalmar C

Published
2022
Full Text
View/download PDF

2. Biliopancreatic and biliary leak after pancreatoduodenectomy treated by percutaneous transhepatic biliary drainage

Author

Henry, Anne Claire, Smits, F. Jasmijn, van Lienden, Krijn, van den Heuvel, Daniel A.F., Hofman, Lieke, Busch, Olivier R., van Delden, Otto M., Zijlstra, IJsbrand A., Schreuder, Sanne M., Lamers, Armand B., van Leersum, Marc, van Strijen, Marco J.L., Vos, Jan A., Te Riele, Wouter W., Molenaar, I. Quintus, Besselink, Marc G., and van Santvoort, Hjalmar C.

Published
2022
Full Text
View/download PDF

3. The Difficulty of Detecting Occult Metastases in Patients with Potentially Resectable Pancreatic Cancer: Development and External Validation of a Preoperative Prediction Model

Author

Walma, Marieke, primary, Maggino, Laura, additional, Smits, F. Jasmijn, additional, Borggreve, Alicia S., additional, Daamen, Lois A., additional, Groot, Vincent P., additional, Casciani, Fabio, additional, de Meijer, Vincent E., additional, Wessels, Frank J., additional, van der Schelling, George P., additional, Nieuwenhuijs, Vincent B., additional, Bosscha, Koop, additional, van der Harst, Erwin van der, additional, van Dam, Ronald van, additional, Liem, Mike S., additional, Festen, Sebastiaan, additional, Stommel, Martijn W. J., additional, Roos, Daphne, additional, Wit, Fennie, additional, de Hingh, Ignace H. de, additional, Bonsing, Bert A., additional, Busch, Olivier R., additional, Groot Koerkamp, Bas, additional, Kazemier, Geert, additional, Besselink, Marc G., additional, Salvia, Roberto, additional, Malleo, Giuseppe, additional, Molenaar, I. Quintus, additional, and van Santvoort, Hjalmar C., additional

Published
2024
Full Text
View/download PDF

4. The Difficulty of Detecting Occult Metastases in Patients with Potentially Resectable Pancreatic Cancer:Development and External Validation of a Preoperative Prediction Model

Author

Walma, Marieke, Maggino, Laura, Smits, F. Jasmijn, Borggreve, Alicia S., Daamen, Lois A., Groot, Vincent P., Casciani, Fabio, de Meijer, Vincent E., Wessels, Frank J., van der Schelling, George P., Nieuwenhuijs, Vincent B., Bosscha, Koop, Harst, Erwin van der, Dam, Ronald van, Liem, Mike S., Festen, Sebastiaan, Stommel, Martijn W.J., Roos, Daphne, Wit, Fennie, Hingh, Ignace H.de, Bonsing, Bert A., Busch, Olivier R., Groot Koerkamp, Bas, Kazemier, Geert, Besselink, Marc G., Salvia, Roberto, Malleo, Giuseppe, Molenaar, I. Quintus, van Santvoort, Hjalmar C., Walma, Marieke, Maggino, Laura, Smits, F. Jasmijn, Borggreve, Alicia S., Daamen, Lois A., Groot, Vincent P., Casciani, Fabio, de Meijer, Vincent E., Wessels, Frank J., van der Schelling, George P., Nieuwenhuijs, Vincent B., Bosscha, Koop, Harst, Erwin van der, Dam, Ronald van, Liem, Mike S., Festen, Sebastiaan, Stommel, Martijn W.J., Roos, Daphne, Wit, Fennie, Hingh, Ignace H.de, Bonsing, Bert A., Busch, Olivier R., Groot Koerkamp, Bas, Kazemier, Geert, Besselink, Marc G., Salvia, Roberto, Malleo, Giuseppe, Molenaar, I. Quintus, and van Santvoort, Hjalmar C.

Abstract

Occult metastases are detected in 10–15% of patients during exploratory laparotomy for pancreatic cancer. This study developed and externally validated a model to predict occult metastases in patients with potentially resectable pancreatic cancer. Model development was performed within the Dutch Pancreatic Cancer Audit, including all patients operated for pancreatic cancer (January 2013–December 2017). Multivariable logistic regression analysis based on the Akaike Information Criteria was performed with intraoperative pathologically proven metastases as the outcome. The model was externally validated with a cohort from the University Hospital of Verona (January 2013–December 2017). For model development, 2262 patients were included of whom 235 (10%) had occult metastases, located in the liver (n = 143, 61%), peritoneum (n = 73, 31%), or both (n = 19, 8%). The model included age (OR 1.02, 95% CI 1.00–1.03), BMI (OR 0.96, 95% CI 0.93–0.99), preoperative nutritional support (OR 1.73, 95% CI 1.01–2.74), tumor diameter (OR 1.60, 95% CI 1.04–2.45), tumor composition (solid vs. cystic) (OR 2.33, 95% CI 1.20–4.35), and indeterminate lesions on preoperative imaging (OR 4.01, 95% CI 2.16–7.43). External validation showed poor discrimination with a C-statistic of 0.56. Although some predictor variables were significantly associated with occult metastases, the model performed insufficiently at external validation.

Published
2024

6. Impact of Complications After Pancreatoduodenectomy on Mortality, Organ Failure, Hospital Stay, and Readmission: Analysis of a Nationwide Audit

Author

Smits, F. Jasmijn, Verweij, Maaike E., Daamen, Lois A., van Werkhoven, C. Henri, Goense, Lucas, Besselink, Marc G., Bonsing, Bert A., Busch, Olivier R., van Dam, Ronald M., van Eijck, Casper H. J., Festen, Sebastiaan, Koerkamp, Bas Groot, van der Harst, Erwin, de Hingh, Ignace H., Kazemier, Geert, Klaase, Joost M., van der Kolk, Marion, Liem, Mike, Luyer, Misha D. P., Meerdink, Mark, Mieog, J. Sven D., Nieuwenhuijs, Vincent B., Roos, Daphne, Schreinemakers, Jennifer M., Stommel, Martijn W., Wit, Fennie, Zonderhuis, Babs M., de Meijer, Vincent E., van Santvoort, Hjalmar C., and Molenaar, I. Quintus

Published
2022
Full Text
View/download PDF

8. Impact of complications after resection of pancreatic cancer on disease recurrence and survival, and mediation effect of adjuvant chemotherapy: nationwide, observational cohort study

Author

Henry, Anne Claire, primary, van Dongen, Jelle C, additional, van Goor, Iris W J M, additional, Smits, F Jasmijn, additional, Nagelhout, Anne, additional, Besselink, Marc G, additional, Busch, Olivier R, additional, Bonsing, Bert A, additional, Bosscha, Koop, additional, van Dam, Ronald M, additional, Festen, Sebastiaan, additional, Groot Koerkamp, Bas, additional, van der Harst, Erwin, additional, de Hingh, Ignace H, additional, van der Kolk, Marion, additional, Liem, Mike S L, additional, de Meijer, Vincent E, additional, Patijn, Gijs A, additional, Roos, Daphne, additional, Schreinemakers, Jennifer M, additional, Wit, Fennie, additional, Daamen, Lois A, additional, van Santvoort, Hjalmar C, additional, Molenaar, I Quintus, additional, and van Eijck, Casper H J, additional

Published
2023
Full Text
View/download PDF

9. Impact of complications after resection of pancreatic cancer on disease recurrence and survival, and mediation effect of adjuvant chemotherapy:nationwide, observational cohort study

Author

Henry, Anne Claire, van Dongen, Jelle C, van Goor, Iris W J M, Smits, F Jasmijn, Nagelhout, Anne, Besselink, Marc G, Busch, Olivier R, Bonsing, Bert A, Bosscha, Koop, van Dam, Ronald M, Festen, Sebastiaan, Groot Koerkamp, Bas, van der Harst, Erwin, de Hingh, Ignace H, van der Kolk, Marion, Liem, Mike S L, de Meijer, Vincent E, Patijn, Gijs A, Roos, Daphne, Schreinemakers, Jennifer M, Wit, Fennie, Daamen, Lois A, van Santvoort, Hjalmar C, Molenaar, I Quintus, van Eijck, Casper H J, Henry, Anne Claire, van Dongen, Jelle C, van Goor, Iris W J M, Smits, F Jasmijn, Nagelhout, Anne, Besselink, Marc G, Busch, Olivier R, Bonsing, Bert A, Bosscha, Koop, van Dam, Ronald M, Festen, Sebastiaan, Groot Koerkamp, Bas, van der Harst, Erwin, de Hingh, Ignace H, van der Kolk, Marion, Liem, Mike S L, de Meijer, Vincent E, Patijn, Gijs A, Roos, Daphne, Schreinemakers, Jennifer M, Wit, Fennie, Daamen, Lois A, van Santvoort, Hjalmar C, Molenaar, I Quintus, and van Eijck, Casper H J

Abstract

Background: The causal pathway between complications after pancreatic cancer resection and impaired long-term survival remains unknown. The aim of this study was to investigate the impact of complications after pancreatic cancer resection on disease-free interval and overall survival, with adjuvant chemotherapy as a mediator. Methods: This observational study included all patients undergoing pancreatic cancer resection in the Netherlands (2014-2017). Clinical data were extracted from the prospective Dutch Pancreatic Cancer Audit. Recurrence and survival data were collected additionally. In causal mediation analysis, direct and indirect effect estimates via adjuvant chemotherapy were calculated. Results: In total, 1071 patients were included. Major complications (hazards ratio 1.22 (95 per cent c.i. 1.04 to 1.43); P = 0.015 and hazards ratio 1.25 (95 per cent c.i. 1.08 to 1.46); P = 0.003) and organ failure (hazards ratio 1.86 (95 per cent c.i. 1.32 to 2.62); P < 0.001 and hazards ratio 1.89 (95 per cent c.i. 1.36 to 2.63); P < 0.001) were associated with shorter disease-free interval and overall survival respectively. The effects of major complications and organ failure on disease-free interval (-1.71 (95 per cent c.i. -2.27 to -1.05) and -3.05 (95 per cent c.i. -4.03 to -1.80) respectively) and overall survival (-1.92 (95 per cent c.i. -2.60 to -1.16) and -3.49 (95 per cent c.i. -4.84 to -2.03) respectively) were mediated by adjuvant chemotherapy. Additionally, organ failure directly affected disease-free interval (-5.38 (95 per cent c.i. -9.27 to -1.94)) and overall survival (-6.32 (95 per cent c.i. -10.43 to -1.99)). In subgroup analyses, the association was found in patients undergoing pancreaticoduodenectomy, but not in patients undergoing distal pancreatectomy. Conclusion: Major complications, including organ failure, negatively impact survival in patients after pancreatic cancer resection, largely mediated by adjuvant chemotherapy. Prevention or adeq

Published
2023

10. Nationwide Outcome after Pancreatoduodenectomy in Patients at very High Risk (ISGPS-D) for Postoperative Pancreatic Fistula

Author

Theijse, Rutger T, Stoop, Thomas F, Hendriks, Tessa E, Suurmeijer, J Annelie, Smits, F Jasmijn, Bonsing, Bert A, Lips, Daan J, Manusama, Eric, van der Harst, Erwin, Patijn, Gijs A, Wijsman, Jan H, Meerdink, Mark, den Dulk, Marcel, van Dam, Ronald, Stommel, Martijn W J, van Laarhoven, Kees, de Wilde, Roeland F, Festen, Sebastiaan, Draaisma, Werner A, Bosscha, Koop, van Eijck, Casper H J, Busch, Olivier R, Molenaar, I Quintus, Groot Koerkamp, Bas, van Santvoort, Hjalmar C, Besselink, Marc G, Theijse, Rutger T, Stoop, Thomas F, Hendriks, Tessa E, Suurmeijer, J Annelie, Smits, F Jasmijn, Bonsing, Bert A, Lips, Daan J, Manusama, Eric, van der Harst, Erwin, Patijn, Gijs A, Wijsman, Jan H, Meerdink, Mark, den Dulk, Marcel, van Dam, Ronald, Stommel, Martijn W J, van Laarhoven, Kees, de Wilde, Roeland F, Festen, Sebastiaan, Draaisma, Werner A, Bosscha, Koop, van Eijck, Casper H J, Busch, Olivier R, Molenaar, I Quintus, Groot Koerkamp, Bas, van Santvoort, Hjalmar C, and Besselink, Marc G

Abstract

OBJECTIVE: To assess nationwide surgical outcome after pancreatoduodenectomy (PD) in patients at very high risk for postoperative pancreatic fistula (POPF), categorized as ISGPS-D.SUMMARY BACKGROUND DATA: Morbidity and mortality after ISGPS-D PD is perceived so high that a recent randomized trial advocated prophylactic total pancreatectomy (TP) as alternative aiming to lower this risk. However, current outcomes of ISGPS-D PD remain unknown as large nationwide series are lacking.METHODS: Nationwide retrospective analysis including consecutive patients undergoing ISGPS-D PD (i.e., soft texture and pancreatic duct ≤3 mm), using the mandatory Dutch Pancreatic Cancer Audit (2014-2021). Primary outcome was in-hospital mortality and secondary outcomes included major morbidity (i.e., Clavien-Dindo grade ≥IIIa) and POPF (ISGPS grade B/C). The use of prophylactic TP to avoid POPF during the study period was assessed.RESULTS: Overall, 1402 patients were included. In-hospital mortality was 4.1% (n=57), which decreased to 3.7% (n=20/536) in the last 2 years. Major morbidity occurred in 642 patients (45.9%) and POPF in 410 (30.0%), which corresponded with failure to rescue in 8.9% (n=57/642). Patients with POPF had increased rates of major morbidity (88.0% vs. 28.3%; P<0.001) and mortality (6.3% vs. 3.5%; P=0.016), compared to patients without POPF. Among 190 patients undergoing TP, prophylactic TP to prevent POPF was performed in 4 (2.1%).CONCLUSION: This nationwide series found a 4.1% in-hospital mortality after ISGPS-D PD with 45.9% major morbidity, leaving little room for improvement through prophylactic TP. Nevertheless, given the outcomes in 30% of patients who develop POPF, future randomized trials should aim to prevent and mitigate POPF in this high-risk category.

Published
2023

11. Risk Models for Developing Pancreatic Fistula after Pancreatoduodenectomy: Validation in a Nationwide Prospective Cohort

Author

Schouten, Thijs J, Henry, Anne Claire, Smits, F Jasmijn, Besselink, Marc G, Bonsing, Bert A, Bosscha, Koop, Busch, Olivier R, van Dam, Ronald M, van Eijck, Casper H, Festen, Sebastiaan, Groot Koerkamp, Bas, van der Harst, Erwin, de Hingh, Ignace H J T, Kazemier, Geert, Liem, Mike S L, de Meijer, Vincent E, Patijn, Gijs A, Roos, Daphne, Schreinemakers, Jennifer M J, Stommel, Martijn W J, Wit, Fennie, Daamen, Lois A, Molenaar, I Quintus, van Santvoort, Hjalmar C, Surgery, and Pediatric Surgery

Abstract

OBJECTIVE: To evaluate the performance of published fistula risk models by external validation, and to identify independent risk factors for postoperative pancreatic fistula (POPF). SUMMARY BACKGROUND DATA: Multiple risk models have been developed to predict POPF after pancreatoduodenectomy. External validation in high-quality prospective cohorts is, however, lacking or only performed for individual models. METHODS: A post-hoc analysis of data from the stepped-wedge cluster randomized PORSCH trial was performed. Included were all patients undergoing pancreatoduodenectomy in the Netherlands (January 2018-November 2019). Risk models on POPF were identified by a systematic literature search. Model performance was evaluated by calculating the area under the receiver operating curves (AUC) and calibration plots. Multivariable logistic regression was performed to identify independent risk factors associated with clinically relevant POPF. RESULTS: Overall, 1358 patients undergoing pancreatoduodenectomy were included, of whom 341 patients (25%) developed clinically relevant POPF. Fourteen risk models for POPF were evaluated, with AUCs ranging from 0.62-0.70. The updated alternative fistula risk score had an AUC of 0.70 (95% CI 0.69-0.72). The alternative fistula risk score demonstrated an AUC of 0.70 (95% CI 0.68-0.71), whilst an AUC of 0.70 (95% CI 0.69-0.71) was also found for the model by Petrova et al Soft pancreatic texture, pathology other than pancreatic ductal adenocarcinoma or chronic pancreatitis, small pancreatic duct diameter, higher body-mass index, minimally invasive resection and male sex were identified as independent predictors of POPF. CONCLUSION: Published risk models predicting clinically relevant POPF after pancreatoduodenectomy have a moderate predictive accuracy. Their clinical applicability to identify high-risk patients and guide treatment strategies is therefore questionable.

Published
2023

13. Alternative Fistula Risk Score for Pancreatoduodenectomy (a-FRS): Design and International External Validation

Author

Mungroop, Timothy H., van Rijssen, L. Bengt, van Klaveren, David, Smits, F. Jasmijn, van Woerden, Victor, Linnemann, Ralph J., de Pastena, Matteo, Klompmaker, Sjors, Marchegiani, Giovanni, Ecker, Brett L., van Dieren, Susan, Bonsing, Bert, Busch, Olivier R., van Dam, Ronald M., Erdmann, Joris, van Eijck, Casper H., Gerhards, Michael F., van Goor, Harry, van der Harst, Erwin, de Hingh, Ignace H., de Jong, Koert P., Kazemier, Geert, Luyer, Misha, Shamali, Awad, Barbaro, Salvatore, Armstrong, Thomas, Takhar, Arjun, Hamady, Zaed, Klaase, Joost, Lips, Daan J., Molenaar, I. Quintus, Nieuwenhuijs, Vincent B., Rupert, Coen, van Santvoort, Hjalmar C., Scheepers, Joris J., van der Schelling, George P., Bassi, Claudio, Vollmer, Charles M., Steyerberg, Ewout W., Abu Hilal, Mohammed, Groot Koerkamp, Bas, and Besselink, Marc G.

Published
2019
Full Text
View/download PDF

16. Algorithm-based care versus usual care for the early recognition and management of complications after pancreatic resection in the Netherlands: an open-label, nationwide, stepped-wedge cluster-randomised trial

Author

Smits, F Jasmijn, primary, Henry, Anne Claire, additional, Besselink, Marc G, additional, Busch, Olivier R, additional, van Eijck, Casper H, additional, Arntz, Mark, additional, Bollen, Thomas L, additional, van Delden, Otto M, additional, van den Heuvel, Daniel, additional, van der Leij, Christiaan, additional, van Lienden, Krijn P, additional, Moelker, Adriaan, additional, Bonsing, Bert A, additional, Borel Rinkes, Inne H, additional, Bosscha, Koop, additional, van Dam, Ronald M, additional, Derksen, Wouter J M, additional, den Dulk, Marcel, additional, Festen, Sebastiaan, additional, Groot Koerkamp, Bas, additional, de Haas, Robbert J, additional, Hagendoorn, Jeroen, additional, van der Harst, Erwin, additional, de Hingh, Ignace H, additional, Kazemier, Geert, additional, van der Kolk, Marion, additional, Liem, Mike, additional, Lips, Daan J, additional, Luyer, Misha D, additional, de Meijer, Vincent E, additional, Mieog, J Sven, additional, Nieuwenhuijs, Vincent B, additional, Patijn, Gijs A, additional, te Riele, Wouter W, additional, Roos, Daphne, additional, Schreinemakers, Jennifer M, additional, Stommel, Martijn W J, additional, Wit, Fennie, additional, Zonderhuis, Babs A, additional, Daamen, Lois A, additional, van Werkhoven, C Henri, additional, Molenaar, I Quintus, additional, van Santvoort, Hjalmar C, additional, Blomjous, JG, additional, de Boer, MT, additional, van den Boezem, P, additional, Bouwense, S, additional, Bruijnen, R, additional, Buis, CI, additional, del Chiaro, M, additional, Coene, PP, additional, Coolsen, M, additional, Daams, F, additional, Dejong, K, additional, Draaisma, W, additional, Eker, HH, additional, Elsen, AH, additional, Gerhards, MF, additional, Hartog, H, additional, Hoogwater, FJ, additional, Imani, F, additional, Jenniskens, S, additional, de Jong, KP, additional, Karsten, TM, additional, Klaase, JM, additional, de Kleine, RHJ, additional, van Laarhoven, CJ, additional, van der Lelij, H, additional, Manusama, ER, additional, Meerdink, M, additional, Meijerink, M, additional, Nederend, J, additional, Nijkamp, MW, additional, Nota, CL, additional, Porte, RJ, additional, Reef, J, additional, de Reuver, P, additional, van Rijswijk, C, additional, Romkens, T, additional, Rupert, C, additional, van der Schelling, GP, additional, Serafino, JP, additional, Vos, LD, additional, Vriens, MR, additional, Beers-Vural, E, additional, Wagtenberg, JM, additional, Wijsman, JH, additional, de Wilde, RF, additional, Wolfgang, CL, additional, and Zeh, HJ, additional

Published
2022
Full Text
View/download PDF

18. Algorithm-based care after pancreatic resection – Authors' reply

Author

CTC, MS CGO, Cancer, MS HOD, Smits, F. Jasmijn, Henry, Anne Claire, Molenaar, I. Quintus, van Santvoort, Hjalmar C., CTC, MS CGO, Cancer, MS HOD, Smits, F. Jasmijn, Henry, Anne Claire, Molenaar, I. Quintus, and van Santvoort, Hjalmar C.

Published
2022

19. Biliopancreatic and biliary leak after pancreatoduodenectomy treated by percutaneous transhepatic biliary drainage

Author

MS CGO, Heelkunde Opleiding, Externen Hematologie, Cancer, MS HOD, Henry, Anne Claire, Smits, F. Jasmijn, van Lienden, Krijn, van den Heuvel, Daniel A.F., Hofman, Lieke, Busch, Olivier R., van Delden, Otto M., Zijlstra, IJsbrand A., Schreuder, Sanne M., Lamers, Armand B., van Leersum, Marc, van Strijen, Marco J.L., Vos, Jan A., Te Riele, Wouter W., Molenaar, I. Quintus, Besselink, Marc G., van Santvoort, Hjalmar C., MS CGO, Heelkunde Opleiding, Externen Hematologie, Cancer, MS HOD, Henry, Anne Claire, Smits, F. Jasmijn, van Lienden, Krijn, van den Heuvel, Daniel A.F., Hofman, Lieke, Busch, Olivier R., van Delden, Otto M., Zijlstra, IJsbrand A., Schreuder, Sanne M., Lamers, Armand B., van Leersum, Marc, van Strijen, Marco J.L., Vos, Jan A., Te Riele, Wouter W., Molenaar, I. Quintus, Besselink, Marc G., and van Santvoort, Hjalmar C.

Published
2022

20. Additional file 1 of Care after pancreatic resection according to an algorithm for early detection and minimally invasive management of pancreatic fistula versus current practice (PORSCH-trial): design and rationale of a nationwide stepped-wedge cluster-randomized trial

Author

Smits, F. Jasmijn, Henry, Anne Claire, Eijck, Casper H. Van, Besselink, Marc G., Busch, Olivier R., Arntz, Mark, Bollen, Thomas L., Delden, Otto M. Van, Heuvel, Daniel Van Den, Leij, Christiaan Van Der, Lienden, Krijn P. Van, Moelker, Adriaan, Bonsing, Bert A., Rinkes, Inne H. M. Borel, Bosscha, Koop, R. M. Van Dam, Festen, Sebastiaan, B. Groot Koerkamp, Harst, Erwin Van Der, Hingh, Ignace H. De, Kazemier, Geert, Liem, Mike, B. Marion Van Der Kolk, Meijer, Vincent E. De, Patijn, Gijs A., Roos, Daphne, Schreinemakers, Jennifer M., Wit, Fennie, C. Henri Van Werkhoven, I. Quintus Molenaar, and Santvoort, Hjalmar C. Van

Subjects
ComputingMilieux_THECOMPUTINGPROFESSION, GeneralLiterature_INTRODUCTORYANDSURVEY, ComputingMilieux_COMPUTERSANDEDUCATION, Software_PROGRAMMINGLANGUAGES
Abstract

Additional file 1: Appendix 1. Design of the Algorithm. Appendix 2. Interpretation And Rationale of the Algorithm.

Published
2020
Full Text
View/download PDF

21. C-reactive protein is superior to white blood cell count for early detection of complications after pancreatoduodenectomy: a retrospective multicenter cohort study

Author

MS CGO, MS HOD, Cancer, van Dongen, Jelle C., Smits, F. Jasmijn, van Santvoort, Hjalmar C., Molenaar, I. Quintus, Busch, Olivier R., Besselink, Marc G., Aziz, M. Hossein, Koerkamp, Bas Groot, van Eijck, Casper H. J., MS CGO, MS HOD, Cancer, van Dongen, Jelle C., Smits, F. Jasmijn, van Santvoort, Hjalmar C., Molenaar, I. Quintus, Busch, Olivier R., Besselink, Marc G., Aziz, M. Hossein, Koerkamp, Bas Groot, and van Eijck, Casper H. J.

Published
2020

23. C-reactive protein is superior to white blood cell count for early detection of complications after pancreatoduodenectomy: a retrospective multicenter cohort study

Author

van Dongen, Jelle C., primary, Smits, F. Jasmijn, additional, van Santvoort, Hjalmar C., additional, Molenaar, I. Quintus, additional, Busch, Olivier R., additional, Besselink, Marc G., additional, Aziz, M. Hossein, additional, Groot Koerkamp, Bas, additional, and van Eijck, Casper H.J., additional

Published
2020
Full Text
View/download PDF

24. Impact of Complications After Pancreatoduodenectomy on Mortality, Organ Failure, Hospital Stay, and Readmission

Author

Smits, F. Jasmijn, primary, Verweij, Maaike E., additional, Daamen, Lois A., additional, van Werkhoven, C. Henri, additional, Goense, Lucas, additional, Besselink, Marc G., additional, Bonsing, Bert A., additional, Busch, Olivier R., additional, van Dam, Ronald M., additional, van Eijck, Casper H. J., additional, Festen, Sebastiaan, additional, Koerkamp, Bas Groot, additional, van der Harst, Erwin, additional, de Hingh, Ignace H., additional, Kazemier, Geert, additional, Klaase, Joost M., additional, van der Kolk, Marion, additional, Liem, Mike, additional, Luyer, Misha D. P., additional, Meerdink, Mark, additional, Mieog, J. Sven D., additional, Nieuwenhuijs, Vincent B., additional, Roos, Daphne, additional, Schreinemakers, Jennifer M., additional, Stommel, Martijn W., additional, Wit, Fennie, additional, Zonderhuis, Babs M., additional, de Meijer, Vincent E., additional, van Santvoort, Hjalmar C., additional, and Molenaar, I. Quintus, additional

Published
2020
Full Text
View/download PDF

26. The risk of not receiving adjuvant chemotherapy after resection of pancreatic ductal adenocarcinoma: a nationwide analysis

Author

Mackay, Tara M., primary, Smits, F. Jasmijn, additional, Roos, Daphne, additional, Bonsing, Bert A., additional, Bosscha, Koop, additional, Busch, Olivier R., additional, Creemers, Geert-Jan, additional, van Dam, Ronald M., additional, van Eijck, Casper H.J., additional, Gerhards, Michael F., additional, de Groot, Jan Willem B., additional, Groot Koerkamp, Bas, additional, Haj Mohammad, Nadia, additional, van der Harst, Erwin, additional, de Hingh, Ignace H.J.T., additional, Homs, Marjolein Y.V., additional, Kazemier, Geert, additional, Liem, Mike S.L., additional, de Meijer, Vincent E., additional, Molenaar, I. Quintus, additional, Nieuwenhuijs, Vincent B., additional, van Santvoort, Hjalmar C., additional, van der Schelling, George P., additional, Stommel, Martijn W.J., additional, ten Tije, Albert Jan, additional, de Vos-Geelen, Judith, additional, Wit, Fennie, additional, Wilmink, Johanna W., additional, van Laarhoven, Hanneke W.M., additional, and Besselink, Marc G., additional

Published
2020
Full Text
View/download PDF

28. Alternative Fistula Risk Score for Pancreatoduodenectomy (a-FRS): Design and International External Validation

Author

Zorgeenheid Vaatchirurgie Zorg, MS CGO, Cardiovasculaire Epi Team 1, Cancer, Mungroop, Timothy H., Van Rijssen, L. Bengt, Van Klaveren, David, Smits, F. Jasmijn, Van Woerden, Victor, Linnemann, Ralph J., De Pastena, Matteo, Klompmaker, Sjors, Marchegiani, Giovanni, Ecker, Brett L., Van Dieren, Susan, Bonsing, Bert, Busch, Olivier R., Van Dam, Ronald M., Erdmann, Joris, Van Eijck, Casper H., Gerhards, Michael F., Van Goor, Harry, Van Der Harst, Erwin, De Hingh, Ignace H., De Jong, Koert P., Kazemier, Geert, Luyer, Misha, Shamali, Awad, Barbaro, Salvatore, Armstrong, Thomas, Takhar, Arjun, Hamady, Zaed, Klaase, Joost, Lips, Daan J., Molenaar, I. Quintus, Nieuwenhuijs, Vincent B., Rupert, Coen, Van Santvoort, Hjalmar C., Scheepers, Joris J., Van Der Schelling, George P., Bassi, Claudio, Vollmer, Charles M., Steyerberg, Ewout W., Abu Hilal, Mohammed, Groot Koerkamp, Bas, Besselink, Marc G., Zorgeenheid Vaatchirurgie Zorg, MS CGO, Cardiovasculaire Epi Team 1, Cancer, Mungroop, Timothy H., Van Rijssen, L. Bengt, Van Klaveren, David, Smits, F. Jasmijn, Van Woerden, Victor, Linnemann, Ralph J., De Pastena, Matteo, Klompmaker, Sjors, Marchegiani, Giovanni, Ecker, Brett L., Van Dieren, Susan, Bonsing, Bert, Busch, Olivier R., Van Dam, Ronald M., Erdmann, Joris, Van Eijck, Casper H., Gerhards, Michael F., Van Goor, Harry, Van Der Harst, Erwin, De Hingh, Ignace H., De Jong, Koert P., Kazemier, Geert, Luyer, Misha, Shamali, Awad, Barbaro, Salvatore, Armstrong, Thomas, Takhar, Arjun, Hamady, Zaed, Klaase, Joost, Lips, Daan J., Molenaar, I. Quintus, Nieuwenhuijs, Vincent B., Rupert, Coen, Van Santvoort, Hjalmar C., Scheepers, Joris J., Van Der Schelling, George P., Bassi, Claudio, Vollmer, Charles M., Steyerberg, Ewout W., Abu Hilal, Mohammed, Groot Koerkamp, Bas, and Besselink, Marc G.

Published
2019

29. Predicting Successful Catheter Drainage in Patients with Pancreatic Fistula after Pancreatoduodenectomy

Author

Arts Assistenten CTC, MS CGO, Cancer, Regenerative Medicine and Stem Cells, Smits, F. Jasmijn, Van Santvoort, Hjalmar C., Besselink, Marc G., Boerma, Djamila, Busch, Olivier R., Van Dam, Ronald M., Van Eijck, Casper H., Festen, Sebastiaan, Van Der Harst, Erwin, De Hingh, Ignace H., De Jong, Koert P., Borel Rinkes, Inne H., Molenaar, I. Quintus, Arts Assistenten CTC, MS CGO, Cancer, Regenerative Medicine and Stem Cells, Smits, F. Jasmijn, Van Santvoort, Hjalmar C., Besselink, Marc G., Boerma, Djamila, Busch, Olivier R., Van Dam, Ronald M., Van Eijck, Casper H., Festen, Sebastiaan, Van Der Harst, Erwin, De Hingh, Ignace H., De Jong, Koert P., Borel Rinkes, Inne H., and Molenaar, I. Quintus

Published
2019

32. Care after pancreatic resection according to an algorithm for early detection and minimally invasive management of pancreatic fistula versus current practice (PORSCH-trial): design and rationale of a nationwide stepped-wedge cluster-randomized trial.

Author

Smits, F. Jasmijn, Henry, Anne Claire, van Eijck, Casper H., Besselink, Marc G., Busch, Olivier R., Arntz, Mark, Bollen, Thomas L., van Delden, Otto M., van den Heuvel, Daniel, van der Leij, Christiaan, van Lienden, Krijn P., Moelker, Adriaan, Bonsing, Bert A., Borel Rinkes, Inne H. M., Bosscha, Koop, van Dam, R. M., Festen, Sebastiaan, Groot Koerkamp, B., van der Harst, Erwin, and de Hingh, Ignace H.

Subjects
*PANCREATIC fistula, *PANCREATIC surgery, *SURGICAL complications, *ALGORITHMS, *COST analysis, *INVASIVE candidiasis, *POSTOPERATIVE pain
Abstract

Background: Pancreatic resection is a major abdominal operation with 50% risk of postoperative complications. A common complication is pancreatic fistula, which may have severe clinical consequences such as postoperative bleeding, organ failure and death. The objective of this study is to investigate whether implementation of an algorithm for early detection and minimally invasive management of pancreatic fistula may improve outcomes after pancreatic resection.Methods: This is a nationwide stepped-wedge, cluster-randomized, superiority trial, designed in adherence to the Consolidated Standards of Reporting Trials (CONSORT) guidelines. During a period of 22 months, all Dutch centers performing pancreatic surgery will cross over in a randomized order from current practice to best practice according to the algorithm. This evidence-based and consensus-based algorithm will provide daily multilevel advice on the management of patients after pancreatic resection (i.e. indication for abdominal imaging, antibiotic treatment, percutaneous drainage and removal of abdominal drains). The algorithm is designed to aid early detection and minimally invasive step-up management of postoperative pancreatic fistula. Outcomes of current practice will be compared with outcomes after implementation of the algorithm. The primary outcome is a composite of major complications (i.e. post-pancreatectomy bleeding, new-onset organ failure and death) and will be measured in a sample size of at least 1600 patients undergoing pancreatic resection. Secondary endpoints include the individual components of the primary endpoint and other clinical outcomes, healthcare resource utilization and costs analysis. Follow up will be up to 90 days after pancreatic resection.Discussion: It is hypothesized that a structured nationwide implementation of a dedicated algorithm for early detection and minimally invasive step-up management of postoperative pancreatic fistula will reduce the risk of major complications and death after pancreatic resection, as compared to current practice.Trial Registration: Netherlands Trial Register: NL 6671. Registered on 16 December 2017. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

35. Spontaneous Septic Arthritis of Pubic Symphysis in an Elite Athlete

Author

Smits, F. Jasmijn, Frima, Herman, Schaeffeler, Christoph, and Sommer, Christoph

Subjects
Article Subject
Abstract

Septic arthritis of the pubic symphysis is a potentially severe disease. Athletes are at risk of this form of spontaneous arthritis, as inflammation of the pubic bone due to muscular stress is relatively common. Oedema due to inflammation might predispose to infection through bacteraemia or local bacterial translocation. Suspicion should be raised when an athlete complains of groin pain and has signs of infection (i.e., fever, elevated white blood cell count, and elevated C-reactive protein). Diagnosis is made by imaging showing signs of inflammation combined with positive (blood) cultures. Broad spectrum antibiotics should be started upon suspicion and adjusted according to cultures. An abscess causing clinical deterioration under antibiotic treatment is an indication for invasive intervention (i.e., surgical or image-guided drainage). This is the first case of spontaneous septic arthritis of the pubic symphysis in an athlete requiring surgical and additional image-guided drainage.

Published
2016
Full Text
View/download PDF

37. Management of Severe Pancreatic Fistula After Pancreatoduodenectomy.

Author

Smits, F. Jasmijn, van Santvoort, Hjalmar C., Besselink, Marc G., Batenburg, Marilot C. T., Slooff, Robbert A. E., Boerma, Djamila, Busch, Olivier R., Coene, Peter P. L. O., van Dam, Ronald M., van Dijk, David P. J., van Eijck, Casper H. J., Festen, Sebastiaan, van der Harst, Erwin, de Hingh, Ignace H. J. T., de Jong, Koert P., Tol, Johanna A. M. G., Borel Rinkes, Inne H. M., Molenaar, I. Quintus, and Dutch Pancreatic Cancer Group

Published
2017
Full Text
View/download PDF

38. Nationwide Outcome after Pancreatoduodenectomy in Patients at very High Risk (ISGPS-D) for Postoperative Pancreatic Fistula.

Author

Theijse RT, Stoop TF, Hendriks TE, Suurmeijer JA, Smits FJ, Bonsing BA, Lips DJ, Manusama E, van der Harst E, Patijn GA, Wijsman JH, Meerdink M, den Dulk M, van Dam R, Stommel MWJ, van Laarhoven K, de Wilde RF, Festen S, Draaisma WA, Bosscha K, van Eijck CHJ, Busch OR, Molenaar IQ, Groot Koerkamp B, van Santvoort HC, and Besselink MG

Abstract

Objective: To assess nationwide surgical outcome after pancreatoduodenectomy (PD) in patients at very high risk for postoperative pancreatic fistula (POPF), categorized as ISGPS-D., Summary Background Data: Morbidity and mortality after ISGPS-D PD is perceived so high that a recent randomized trial advocated prophylactic total pancreatectomy (TP) as alternative aiming to lower this risk. However, current outcomes of ISGPS-D PD remain unknown as large nationwide series are lacking., Methods: Nationwide retrospective analysis including consecutive patients undergoing ISGPS-D PD (i.e., soft texture and pancreatic duct ≤3 mm), using the mandatory Dutch Pancreatic Cancer Audit (2014-2021). Primary outcome was in-hospital mortality and secondary outcomes included major morbidity (i.e., Clavien-Dindo grade ≥IIIa) and POPF (ISGPS grade B/C). The use of prophylactic TP to avoid POPF during the study period was assessed., Results: Overall, 1402 patients were included. In-hospital mortality was 4.1% (n=57), which decreased to 3.7% (n=20/536) in the last 2 years. Major morbidity occurred in 642 patients (45.9%) and POPF in 410 (30.0%), which corresponded with failure to rescue in 8.9% (n=57/642). Patients with POPF had increased rates of major morbidity (88.0% vs. 28.3%; P<0.001) and mortality (6.3% vs. 3.5%; P=0.016), compared to patients without POPF. Among 190 patients undergoing TP, prophylactic TP to prevent POPF was performed in 4 (2.1%)., Conclusion: This nationwide series found a 4.1% in-hospital mortality after ISGPS-D PD with 45.9% major morbidity, leaving little room for improvement through prophylactic TP. Nevertheless, given the outcomes in 30% of patients who develop POPF, future randomized trials should aim to prevent and mitigate POPF in this high-risk category., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results