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26 results on '"Smith, M. Ryan"'

3. Repeated exposure to eucalyptus wood smoke alters pulmonary gene and metabolic profiles in male Long-Evans rats

Author

Cochran, Samuel J, primary, Dunigan-Russell, Katelyn, additional, Hutton, Grace M, additional, Nguyen, Helen, additional, Schladweiler, Mette C, additional, Jones, Dean P, additional, Williams, Wanda C, additional, Fisher, Anna A, additional, Gilmour, M Ian, additional, Dye, Janice A, additional, Smith, M Ryan, additional, Miller, Colette N, additional, and Gowdy, Kymberly M, additional

Published
2024
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5. Acute hepatic rupture causing hemoperitoneum in a dog with anaphylaxis.

Author

Padmanabhan, Ashok, Smith, M. Ryan, Wurlod, Virginie, Menk Pinto Lima, Jose Cesar, and Del Piero, Fabio

Subjects
*ANAPHYLAXIS, *ASCITIC fluids, *DIROFILARIA immitis, *CARDIAC arrest, *NEMATODE infections, *DOGS, *CHOLECYSTITIS
Abstract

A 2‐year‐old spayed female Siberian Husky was presented with a history of acute onset lethargy, collapse, haematochezia and vomiting. The patient was severely tachycardic and hypotensive. Point‐of‐care ultrasound revealed gallbladder wall thickening and peritoneal effusion consistent with haemorrhage on subsequent abdominocentesis. Despite attempted medical stabilization over the course of several hours, including blood products and multiple autotransfusions, the patient progressed to cardiopulmonary arrest. The dog was successfully resuscitated but was subsequently euthanized. Necropsy revealed a severe, acute hemoperitoneum secondary to rupture of the left lateral liver lobe. A tear in the hepatic capsule was identified along with a large hematoma. A single adult nematode, consistent with Dirofilaria immitis, was found in a pulmonary vessel in the right caudal lung lobe. The remaining necropsy findings were supportive of the clinical diagnosis of anaphylaxis. This report details a case, with necropsy findings, supporting a diagnosis of anaphylaxis and severe, refractory hemoperitoneum resulting from hepatic rupture. Acute hepatic rupture should be considered in cases of anaphylaxis‐related hemoperitoneum. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Perfluoroalkyl Substances and Metabolic Dysregulations over the Life-course: A Longitudinal Metabolome Investigation using Causal Inference Framework

Author

Midya, Vishal, primary, Yao, Meizhen, additional, Smith, M. Ryan, additional, Jones, Dean P., additional, Walker, Douglas I., additional, Aldana, Sandra India, additional, Nielsen, Flemming, additional, Weihe, Pal, additional, Grandjean, Philippe, additional, Bind, Marie Abèle C., additional, and Valvi, Damaskini, additional

Published
2023
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8. Metallomics in pulmonary arterial hypertension patients

Author

El‐Kersh, Karim, primary, Hopkins, C. Danielle, additional, Wu, Xiaoyong, additional, Rai, Shesh N., additional, Cave, Matthew C., additional, Smith, M. Ryan, additional, Go, Young‐Mi, additional, Jones, Dean P., additional, Cai, Lu, additional, and Huang, Jiapeng, additional

Published
2023
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10. Obesity reprograms the pulmonary polyunsaturated fatty acid-derived lipidome, transcriptome, and gene-oxylipin networks

Author

Virk, Rafia, primary, Buddenbaum, Nicole, additional, Al-Shaer, Abrar, additional, Armstrong, Michael, additional, Manke, Jonathan, additional, Reisdorph, Nichole, additional, Sergin, Selin, additional, Fenton, Jenifer I., additional, Wallace, E. Diane, additional, Ehrmann, Brandie M., additional, Lovins, Hannah B., additional, Gowdy, Kymberly M., additional, Smith, M Ryan, additional, Smith, Gregory J., additional, Kelada, Samir N.P., additional, and Shaikh, Saame Raza, additional

Published
2022
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11. Effects of time delay and blood storage methods on analysis of canine venous blood samples with an Element point‐of‐care analyzer.

Author

Rincon, Angie A., Wurlod, Virginie A., Liu, Chin‐Chi, and Smith, M. Ryan

Subjects
BLOOD sampling, BLOOD testing, PARTIAL pressure, BLOOD collection, SAMPLING (Process), HEPARIN, CREATININE
Abstract

Background: Manufacturers of point‐of‐care (POC) analyzers recommend immediate processing and anaerobic collection of blood samples. However, it is not uncommon for clinical scenarios to result in delayed sample processing or room air exposure that could impact the test results. Objective: To investigate the effect of time delay and sample storage method on key POC analytes in canine venous blood samples processed with an Element POC analyzer. Methods: Blood gas analysis was performed on venous blood samples at times 0 (T0), 15, 30, and 60 minutes after sampling using three different storage methods: preheparinized plastic syringes and two different lithium heparin tubes. To determine clinical relevance, results were compared with allowable total error of the respective parameter. Significance was set at P < 0.05. Results: Significant differences between the three storage methods at baseline were found for partial pressure of carbon dioxide (PCO2), partial pressure of oxygen (PO2), base excess, and total hemoglobin. No significant differences up to T60 were found within collection methods for actual bicarbonate (HCO3−), base excess, sodium, potassium, chloride, ionized calcium (iCa), glucose, and BUN. Significant differences within collection methods were found after T0 for creatinine, after 15 minutes for lactate, and after 30 minutes for pH and hematocrit. No significant differences were found for PO2 in samples stored in preheparinized plastic syringes at any time point. Conclusions: These results suggest that HCO3−, sodium, potassium, chloride, iCa, glucose, and BUN are comparable within the three storage methods for up to 60 minutes after sampling without resulting in clinically relevant changes. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Plasma Metabolic Phenotypes of HPV-Associated versus Smoking-Associated Head and Neck Cancer and Patient Survival

Author

Eldridge, Ronald C., primary, Uppal, Karan, additional, Hayes, D. Neil, additional, Smith, M. Ryan, additional, Hu, Xin, additional, Qin, Zhaohui S., additional, Beitler, Jonathan J., additional, Miller, Andrew H., additional, Wommack, Evanthia C., additional, Higgins, Kristin A., additional, Shin, Dong M., additional, Ulrich, Bryan, additional, Qian, David C., additional, Saba, Nabil F., additional, Bruner, Deborah W., additional, Jones, Dean P., additional, and Xiao, Canhua, additional

Published
2021
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15. Severe Rhabdomyolysis Associated with Acute Amphetamine Toxicosis in a Dog

Author

Smith, M. Ryan and Wurlod, Virginie A.

Subjects
Article Subject
Abstract

A 3-year-old female spayed rat terrier presented for hyperactivity and repetitive circling to the right of less than one-hour duration. On examination, the patient was dehydrated, hyperactive, and dysphoric. Laboratory tests initially revealed elevations in creatine kinase (CK) and aspartate aminotransferase (AST). Serial chemistries indicated significant progression of CK elevation to a maximum of 181,900 U/L on day 3 along with the development of profuse myoglobinuria. A urine drug screening test was positive for amphetamine metabolites. This patient was treated with sedatives, aggressive fluid diuresis, and antioxidants. The dog recovered uneventfully with no indicators of renal dysfunction based on serial blood chemistries and was discharged five days after presentation. Follow-up blood chemistries taken four days after discharge revealed near normalization of CK and resolution of myoglobinuria. This case report describes a particularly severe case of rhabdomyolysis associated with amphetamine toxicity and its successful treatment.

Published
2020
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19. Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice

Author

Chandler, Joshua D., primary, Hu, Xin, additional, Ko, Eun-Ju, additional, Park, Soojin, additional, Fernandes, Jolyn, additional, Lee, Young-Tae, additional, Orr, Michael L., additional, Hao, Li, additional, Smith, M. Ryan, additional, Neujahr, David C., additional, Uppal, Karan, additional, Kang, Sang-Moo, additional, Jones, Dean P., additional, and Go, Young-Mi, additional

Published
2019
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21. Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels

Author

Smith, M. Ryan, primary, Vayalil, Praveen K., additional, Zhou, Fen, additional, Benavides, Gloria A., additional, Beggs, Reena R., additional, Golzarian, Hafez, additional, Nijampatnam, Bhavitavya, additional, Oliver, Patsy G., additional, Smith, Robin A.J., additional, Murphy, Michael P., additional, Velu, Sadanandan E., additional, and Landar, Aimee, additional

Published
2016
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23. A Novel Class of Mitochondria-Targeted Soft Electrophiles Modifies Mitochondrial Proteins and Inhibits Mitochondrial Metabolism in Breast Cancer Cells through Redox Mechanisms

Author

Vayalil, Praveen K., primary, Oh, Joo-Yeun, additional, Zhou, Fen, additional, Diers, Anne R., additional, Smith, M. Ryan, additional, Golzarian, Hafez, additional, Oliver, Patsy G., additional, Smith, Robin A. J., additional, Murphy, Michael P., additional, Velu, Sadanandan E., additional, and Landar, Aimee, additional

Published
2015
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26. Evaluation of a Point-of-Care Viscoelastic Coagulation Device in Hispaniolan Amazon Parrots (Amazona ventralis).

Author

Russell, Laken, Tully Jr., Thomas N., and Smith, M. Ryan

Subjects
VISCOELASTICITY, BLOOD coagulation, AMAZON parrots, PROTHROMBIN time, QUANTITATIVE research
Abstract

Patient-side viscoelastic coagulation monitors are easy to use, portable, and provide rapid results. Viscoelastic testing evaluates the formation and lysis of a clot over time, providing information to better assess a patient's true clotting potential. Traditional tests, prothrombin time (pT) and partial thromboplastin time (pTT) measure only coagulation factor function. Viscoelastic testing requires a small blood sample and is useful in diagnosing and treating coagulopathies. Currently, there is no standardized coagulation testing method available for birds. In this cross-sectional study, a viscoelastic coagulation device, the Entegrion Viscoelastic Coagulation Monitor, Vet© (VCM-Vet©) was evaluated. Blood samples were obtained from 26 Hispaniolan Amazon parrots (HAP) via manual restraint. Results were recorded on the device as a graphical output and quantitative viscoelastic measurements. Results were reported using standard rotational thromboelastometry terminology: clotting time (CT), clot formation time (CFT), alpha angle (AA), maximum clot firmness (MCF), clot firmness amplitude at 10 (A10) and 20 (A20) minutes after clot formation, and clot lysis at 30 (LY30) and 45 (LY45) minutes.2,3 Statistical analysis found that all parameters were normally distributed aside from clotting time in seconds. Clot lysis at 30 and 40 minutes were all 100%. There was no appreciable breakdown of the clot during the 60-minute device runtime, and there was no significant difference in any parameter based on sex. Resulting data were consistent across this particular population of HAP, enabling creation of reference ranges for this avian species. Based on our findings the VCM can be used to assess clot potential in HAP and possibly other avian species. [ABSTRACT FROM AUTHOR]

Published
2022

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